Effects of glucocorticoid in patients with tuberculous pleurifis and its influnce on the expression of inflammatory cytokines IL-6 and IL-8

Abstract

Objective To investigate the effects of glucocortieoid in patients with tuberculous pleuritis and its impact on the level of inflammatory cytokines IL-6 and IL-8. Methods From January 2012 to June 2015,193 patients with tuberculous pleuritis were divided into research group and control group by random digits table methodin the TB Prevention Hospital of Binzhou City. The patients in two groups were all given anti-TB medication, and the research group was also given chest injection of dexamethasone treatment on the basis of anti-TB medication treatment. The clinical efficacy and IL-6 and IL-8 level change was observed. Results 89 cases showed good effect, and 9 cases was invalid in research group and there were 74 and 21 cases in control group respectively, and there was significant difference between research group and control group (P 0.05). The levels of inflammatory cytokines IL-6 level after treatment of 3, 6 and 9 d in research group was lower than that in control group [(276.49±27.85) pg/ml vs (350.38±20.01) pg/ml,(195.32±14.35) pg/ml vs (312.51±14.82) pg/ml,(86.74±10.28) pg/ml vs (251.74±16.62) pg/ml, and there was significant difference(P<0.05).and IL-8 level[(576.51±19.79) pg/ml vs (850.64±27.70) pg/ml, (225.30±14.29) pg/ml vs (742.49±15.28) pg/ml, (127.68±11.23) pg/ml vs (443.47±12.63) pg/ml] Conclusions Intrapleural injection of glucocorticoid in the treatment of tuberculous pleurisy, can make the drug directly acts on the chest, better realize the control of inflammatory cytokines, encourage pleural effusion absorption, improve the clinical symptoms early. It is worthy of clinical apphcation. Key words: Ghcocorticoids; Tuberculous Pleurifis; Cell Inflammatory Cytokines