Journal of Cluster Science最新文献

{"title":"Sustainable and Optimized Microwave-assisted Hydrothermal Method for Production of Dual-Adsorptive Reduced Graphene Nanomaterials for Wastewater Remediation","authors":"Mohamed L. EL-Shendidy,&nbsp;Doaa M. EL-Mekkawi,&nbsp;Hoda S. Hafez","doi":"10.1007/s10876-025-02891-2","DOIUrl":"10.1007/s10876-025-02891-2","url":null,"abstract":"<div><p>In this study, a facile, low cost and eco-friendly microwave-assisted hydrothermal method has been used and optimized for large-scale production of reduced graphene oxide (rGO) nanosheets. Different rGO samples have been prepared by the modified Hummers method, followed by microwave-assisted reduction at different MW temperatures of 190, 200, 210, 250 °C for 3, 10, 15, 17, 20 and 25 min irradiation time. The morphological, crystallographic and structural analyses of the different produced rGO samples have been investigated using surface area S_BET, TEM and XRD techniques. The HRTEM images confirm the formation of rGO nanosheets with few lots of wrinkles. The XRD confirmed the complete transformation of GO into rGO after only 15 min of microwave irradiation. The surface area analyses showed a remarkable increase in the S_BET and the total pore volume by reduction of GO into rGO (from 0.7 to 26.3 m².g^-1 and from 0.012 to 0.17 cm².g^-1). The produced rGO samples have been tested for dual adsorptive removal of Fe³⁺ metal ions and methylene blue (MB) dye pollutant. A high adsorptive removal efficiency of 95.5% and 99.5% for Fe³⁺ and MB has been achieved using rGO-17 min, 200 °C optimum sample. The Langmuir isotherm model highlighted adsorption capacities (qm values of 126.1 mg.g^-1 for Fe³⁺ and 27.24 mg.g^-1 for MB), confirming the effectiveness of the optimized rGO sample. Additionally, Form the practical point of view and for the first time, the optimized rGO sample has been tested on real wastewater sample. The removal efficiency of both Fe³⁺ and dye content was approximately 57% after 8 h and 49% after only 2 hours, respectively. This demonstrates an optimized low-cost and sustainable method for wastewater remediation.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10876-025-02891-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation of Boron Bonds in Aromatic Boron Water Complexes B13(H2O)n+ (n = 1,2) and B12H(H2O)+ Analogous to Benzene","authors":"Ting Zhang,&nbsp;Rui-Nan Yuan,&nbsp;Qiang Chen,&nbsp;Si-Dian Li","doi":"10.1007/s10876-025-02897-w","DOIUrl":"10.1007/s10876-025-02897-w","url":null,"abstract":"<div><p>Gas-phase B_<i>n</i>⁺ monocations exhibit strong hydrophilicity due to the prototypical electron-deficiency of boron. Joint chemisorption experiment and first-principles theory investigations performed herein indicate that the experimentally known planar magic-number <i>C</i>_2<i>v</i> B₁₃⁺ can react with H₂O at room temperature to form a series of quasi-planar aromatic boron water complexes <i>C</i>₁ B₁₃(H₂O)⁺ (<b>1</b>), <i>C</i>₂ B₁₃(H₂O)₂⁺ (<b>2</b>), and <i>C</i>₁ B₁₂H(H₂O)⁺ (<b>3</b>) analogous to benzene C₆H₆. Extensive theoretical calculations and analyses unveil their chemisorption pathways, bonding patterns, and more importantly, the effective in-phase LP(H₂O:)→LV(B) orbital overlaps between the more electronegative O atom in H₂O as lone-pair (LP) σ-donor and periphery electron-deficient B atoms in B₁₃⁺ (B₃@B₁₀⁺) and B₁₂H⁺ (B₃@B₉H⁺) with lone vacant (LV) orbitals as LP σ-acceptors, evidencing the existence of the newly proposed boron bonds in chemistry. A LP(H₂O:)→LV(B) boron bond in these boron water complexes possesses about 15 ~ 20% of the dissociation energy of a typical O–B covalent bond. Boron bonds are expected to exist in a wide range of boron-based complex systems with typical molecular ligands like H₂O, CO, and NH₃ as effective σ-donors.</p><h3>Graphical Abstract</h3><p>Joint chemisorption experiment and first-principles theory investigations indicate that B₁₃⁺ monocation can react with H₂O to form a series of quasi-planar aromatic boron water complexes <i>C</i>₁ B₁₃(H₂O)⁺, <i>C</i>₂ B₁₃(H₂O)₂⁺, and <i>C</i>₁ B₁₂H(H₂O)⁺ analogous to benzene, evidencing the existence of boron bonds in chemistry.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid State Synthesis and Material Characterizations of Heat-Sensitive Nanocrystalline Sm3+ Doped NaLi2PO4 for Thermoluminescent Dosimetric Investigations","authors":"Taqmeem Hussain,&nbsp;Muhammad Imran,&nbsp;Tariq Munir,&nbsp;Ishrat Sultana,&nbsp;Furqan Ahmad,&nbsp;Kanwal Younas,&nbsp;Muhammad Masood Mahmood,&nbsp;Khalil Ahmad","doi":"10.1007/s10876-025-02894-z","DOIUrl":"10.1007/s10876-025-02894-z","url":null,"abstract":"<div><p>Nanocrystalline NaLi₂PO₄:Sm³⁺ (0.1 mol %) powder phosphor material was synthesized via solid-state reaction method in air atmosphere. The material was characterized by XRD, FESEM, EDS, FTIR, Raman and UV-Visible spectroscopy. Furthermore, the thermoluminescence (TL) dosimetric response of the nanocrystalline powder samples was also examined. XRD analysis revealed the highly crystalline orthorhombic structure of the primary phase with an average crystallite size of 31 nm, alongside the presence of an additional secondary phase indicative of a distinct material. FESEM revealed significant agglomeration, containing non-uniform, irregular, self-oriented clusters having average particle size of 0.37 μm. EDS verified the substantial weight percentages of Samarium in the NaLi₂PO₄:Sm³⁺ composition. FTIR spectroscopy provided prominent absorption bands at 1060 and 1019 cm⁻¹ corresponding to the stretching vibrations of the (PO₄)³⁻ group. Raman spectroscopy further corroborated the presence of distinct vibrational modes of the (PO₄)³⁻ group, associated with the nanoparticle surface. UV-Visible spectroscopy revealed characteristic charge transfer transition of PO and multiple sharp f–f transitions, including a prominent absorption band at 401 nm attributed to the ⁶H_5/2 →⁶P_3/2 transition of Sm³⁺ ions. The influence of various annealing conditions on the TL response of NaLi₂PO₄:Sm³⁺ was investigated. Samples were irradiated at various doses from ⁶⁰Co γ-source. Phosphor showed a prominent TL peak at 207 °C. TL glow curve of this phosphor, irradiated by ⁶⁰Co γ-rays at 40 Gy dose, measured at heating rate of 10 K/s has 8 deconvoluted glow peaks leading to highly dense trap at 478 K. Moreover, material showed the linear dose response against gamma radiations ranging 0–40 Gy. Based on these results, NaLi₂PO₄:Sm³⁺ (0.1 mol %) is a promising material and has good potential for TL dosimetry.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A High Selective and Sensitive Cr2O72−sensing by a Reusable Cu-based metal-organic Framework","authors":"Lili Yang,&nbsp;Ruiqin Yang,&nbsp;Huailan Zhou,&nbsp;Ke Su,&nbsp;Lu Yang","doi":"10.1007/s10876-025-02905-z","DOIUrl":"10.1007/s10876-025-02905-z","url":null,"abstract":"<div><p>The utilization of metal-organic frameworks (MOFs) as luminescent sensors towards specific ions or molecular sensing has garnered significant attention, owing to their porous and easy-decorated feature. Herein, a Cu-based MOF (noted as SQ-1) has been synthesized using 5-amino-isophthalic acid as a bridging ligand. The SQ-1 was structurally characterized and demonstrated good thermal and water stability. Additionally, the benign luminescent properties of the ligands suggest its potential application as a luminescent sensor for detecting various anions. Notably, SQ-1 exhibited a remarkable selective and sensitive sensing ability towards Cr₂O₇²⁻ compared to other anions <i>via</i> luminescence quenching response, with the <i>K</i>_sv of 3.98 × 10⁴ M⁻¹ and detection limit of 4.32 µM. The quenching mechanism has been explored. Furthermore, this Cu-based MOF shows promise as a reusable luminescent sensor, maintaining functionality over three consecutive sensing cycles.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Crosslinked Chitosan-Tartaric Acid/Nano Copper Oxide Polymer Nanocomposite for Safranin T Dye Adsorption: Characterization and Adsorption Optimization","authors":"Ahmed Saud Abdulhameed,&nbsp;Samaa Abdullah,&nbsp;Abeer A. Altamimi,&nbsp;Mahmoud Abualhaija,&nbsp;Sameer Algburi","doi":"10.1007/s10876-025-02883-2","DOIUrl":"10.1007/s10876-025-02883-2","url":null,"abstract":"<div><p>This study aims to prepare a chitosan-based nanocomposite of crosslinked chitosan-tartaric acid/copper oxide nanoparticles (CTS-TA/CuO) for safranin T (SFT) dye adsorption. The CTS-TA/CuO nanocomposite was extensively characterized using Fourier-transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET) surface area analysis, field emission scanning electron microscopy with energy-dispersive X-ray spectroscopy (FESEM-EDX), and X-ray diffraction (XRD). The BET analysis revealed a mean pore diameter of 12.14 nm and surface area of 7.49 m²/g. The adsorption process was optimized using the Box–Behnken design (BBD), considering key parameters such as CTS-TA/CuO dosage (0.02–0.08 g), solution pH (4–10), and contact time (10–50 min). Kinetic modeling demonstrated that the adsorption followed the pseudo-first-order model, while equilibrium data best fit the Freundlich isotherm model. The maximum adsorption capacity of the CTS-TA/CuO nanocomposite for SFT was computed to be 210.48 mg/g. The adsorption mechanism was attributed to multiple interactions, including electrostatic attractions, n-π interactions, and hydrogen bonding. Overall, the findings of this study highlight the promising capability of the CTS-TA/CuO nanocomposite as an efficient and reliable adsorbent for the removal of SFT dye from polluted water, signifying its prospective utilization in wastewater treatment techniques.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Two New Rhenium Clusters [{Re8Se8(µ-O)3}(CN)18]8– and [{Re12S14}(CN)27]9–","authors":"Aleksei S. Pronin,&nbsp;Yakov M. Gaifulin,&nbsp;Taisiya S. Sukhikh,&nbsp;Vadim V. Yanshole,&nbsp;Yuri V. Mironov","doi":"10.1007/s10876-025-02904-0","DOIUrl":"10.1007/s10876-025-02904-0","url":null,"abstract":"<div><p>The family of chalcogenide rhenium clusters is well represented in the literature by a series of compounds with different nuclearities, including heterometallic complexes. Here we report the synthesis and detailed characterization of new cyanide clusters [{Re₈Se₈(µ-O)₃}(CN)₁₈]^8– and [{Re₁₂S₁₄}(CN)₂₇]^9–. Both compounds were obtained by reactions of ReI₃, RuCl₃ and elemental selenium or sulfur with KCN at elevated temperatures, reflecting attempts to prepare heterometallic complexes with noble metals. The first cluster can be visualized as two fragments [{Re₄Se₄}(CN)₉]^– linked by three µ-O^2– bridging ligands. The second one can be represented as three tetrahedral [{Re₄S₄}(CN)₉]^– fragments linked by two µ₃-bridged sulfide ligands. Two of three {Re₄S₄} cores are additionally linked by direct Re–Re bond.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic activity of microwave-assisted synthesized MoS₂/g-C₃N₄ composite for efficient decomposition of aniline green dye","authors":"Gomathi Ramalingam,&nbsp;Priya Arunkumar,&nbsp;Mashael Daghash Alqahtani,&nbsp;Ahmed M. Elgarahy","doi":"10.1007/s10876-025-02879-y","DOIUrl":"10.1007/s10876-025-02879-y","url":null,"abstract":"&lt;div&gt;&lt;p&gt;The escalating impacts of a rapidly changing climate, coupled with a soaring global population and environmentally damaging consumption habits, have converged to create an unprecedented and severe worldwide water scarcity challenge. This dire situation underscores the urgent need for the development and implementation of advanced wastewater treatment systems capable of generating high-quality effluent suitable for various beneficial purposes. This study successfully synthesized MoS₂, g-C₃N₄, and MoS₂/g-C₃N₄ composites using thermal and microwave-assisted methods, yielding efficient visible-light-driven photocatalysts with potential applications in degrading recalcitrant aniline green (AG) dye. In contrast to much existing research, our work uniquely establishes a systematic relationship between particle size distribution, composite ratio, and photocatalytic activity in MoS₂/g-C₃N₄ composites towards AG dye. Herein, we thoroughly investigated the profound effect of synthesis methods on structural tuning, supported by photocatalytic performance comparison across various composite ratios (1:1, 1:2, and 1:3), providing critical insights into their synergistic mechanisms. A comprehensive suite of advanced techniques were employed to characterize the synthesized materials. The prepared MoS₂ blend structure and layered stacking arrangement for the MoS₂ and bulk-g-C&lt;sub&gt;3&lt;/sub&gt;N&lt;sub&gt;4&lt;/sub&gt; compounds were revealed by the composite material’s XRD analysis; the sizes of MoS₂, pure bulk-g-C&lt;sub&gt;3&lt;/sub&gt;N&lt;sub&gt;4&lt;/sub&gt;, and their composites with various ratios of MoS₂/g-C₃N₄ (1:1, 1:2, and 1:3) were 3.07 nm, 7.54 nm, 4.70 nm, 5.10 nm, and 5.66 nm, respectively. Moreover, the MoS₂/g-C₃N₄ composites exhibited superior photocatalytic activity compared to their individual pure components of 20.82%, and 79.65%, for g-C₃N₄, and MoS₂, respectively. Specifically, the MoS₂/g-C₃N₄ composite with a 1:1 ratio demonstrated the highest degradation efficiency of 94.43% after 120 min of visible light exposure, while the 1:2 and 1:3 ratio composites achieved 81.79%, and 64.05% degradation, respectively. The enhanced photocatalytic activity of the MoS₂/g-C₃N₄ composite is attributed to the synergistic interaction between MoS₂ and g-C₃N₄. This interaction facilitates efficient charge separation, reduces electron-hole recombination, and enhances visible light absorption. Moreover, the long-term reusability of the best-performing composite (1:1) over 7 cycles exhibited minor fluctuations (90.7%) with minimal effectiveness loss, offering undeniable evidence of its exceptional stability and practical viability. These findings collectively highlight an innovative design approach and underscore the prospective uses of MoS₂/g-C₃N₄ composites as environmentally friendly and highly stable photocatalysts for wastewater treatment.&lt;/p&gt;&lt;h3&gt;Graphical Abstract&lt;/h3&gt;&lt;p&gt;The graphical abstract effectively encapsulates several critical elements of our work. It visually summarizes the overall","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Biomass-Supported Nanocomposites from Black Cumin Pulp and their Use as Catalysts in NaBH4 Hydrolysis","authors":"Mehmet Salih Keskin,&nbsp;Mehmet Salih Ağırtaş","doi":"10.1007/s10876-025-02858-3","DOIUrl":"10.1007/s10876-025-02858-3","url":null,"abstract":"<div><p>Co-Cu-Zn-B/black cumin meal(bcm) nanocomposites were synthesized by chemical degradation and deposition method. The structure and morphology of Co-Cu-Zn-B/bcm, which was synthesized at room conditions and active in sodium borohydride hydrolysis, were characterized by SEM, EDS, XRD devices. To prepare the waste black cumin meal as a support material, it was first kept in an autoclave at 180 °C in the oven for 6 h. In this stage, binary and ternary Co-Cu-B/bcm, Co-Zn-B/bcm and Co-Cu-Zn-B/bcm samples and different metal ratios (10–60%) NaBH₄ hydrolysis experimental results were tested. In terms of production from NaBH₄ hydrolysis of the synthesized nanocomposites, it has been observed that the best results are exhibited in those produced with 50% metal ratio and binary metal components Co-Cu-B/bcm, where catalytic activities occur. Co-Cu-B/bcm &gt; Co-Cu-Zn-B/bcm &gt; Co-Zn-B/bcm Maximum energy production rate in terms of catalytic activity and completion time of parts is 1757.1 mL/g.cat at 30 °C it was detected as min. The effects of variables such as NaOH and NaBH₄ compositions in solution, a certain limit and temperature on NaBH₄ hydrolysis were tested separately. The kinetics of the combined products were examined between temperatures (20–50 °C) and then the activation energy was calculated as 37.67 kJ/mol. The activation energy and temperature range obtained show that the catalyst has good activity compared to expensive catalysts.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syntheses, Structures, and Characterizations of Two Superatom-Based Cubic Perovskites","authors":"Yan Liu,&nbsp;Ruibing Wang,&nbsp;Wei Zhang,&nbsp;Yu Zhong,&nbsp;Changyan Yu,&nbsp;Yanhua Li","doi":"10.1007/s10876-025-02896-x","DOIUrl":"10.1007/s10876-025-02896-x","url":null,"abstract":"<div><p>Two new perovskite-type compounds, Na₄Cu₈Sn₃S₁₂ (<b>1</b>) and K₄Cu₈Sn₃S₁₂ (<b>2</b>) were synthesized by a solvothermal method in the existence of excess sulfur as a mineralizer. Two compounds are isostructural and crystallize in cubic space group <i>Fm</i><span>(:stackrel{-}{3})</span><i>c</i> and feature the same anion framework [Cu₈Sn₃S₁₂]_n⁴ⁿ⁻. Compared with perovskite CaTiO₃, the Ti⁴⁺ ions are simultaneously substituted by [Cu₈]⁸⁺ unit, the O²⁻ ions by [SnS₄]⁴⁻ unit, and the Ca²⁺ ions by four alkali metal cations. The above compounds are narrow-band semiconductors with the band gaps of 2.01 eV for compound <b>1</b>, and 2.25 eV for <b>2</b>, and compound <b>1</b> exhibits good photoelectric response performance.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Chemotherapeutic Approaches of Bio-Synthesized Chitosan Encapsulated Cyclophosphamide Loaded Magnetite Nanoparticles for Enhanced Lung Cancer Therapy","authors":"Prabu Velumani,&nbsp;Antalin Casmie A.,&nbsp;Rajeswari Senthilvel,&nbsp;Antony Anista Michael,&nbsp;Vijaya Parthasarathy,&nbsp;Thirunavukkarasu Velusamy","doi":"10.1007/s10876-025-02902-2","DOIUrl":"10.1007/s10876-025-02902-2","url":null,"abstract":"<div><p>The metal oxide nanocarriers are attracting a lot of interest in cancer treatment because of their special characteristics in nanoscale. However, nanomaterials do have several drawbacks in biomedical applications, such as toxicity, biocompatibility, and stability. To reduce the adverse impacts of traditional chemotherapeutics, magnetite (Fe₃O₄ NPs) nanoparticles are showing promise as nanocarriers. In this study, focused on nano-bio interaction of synthesized cyclophosphamide loaded chitosan encapsulated magnetite nanoparticles (Chitosan@CP@Fe₃O₄ NPs). The cyclophosphamide-loaded magnetite nanoparticles have more biocompatibility, less toxicity and more drug encapsulation efficiency and releasing efficiency compared to bare cyclophosphamide and magnetite nanoparticles. The cellular nano-bio interaction was studied in hemocompatibility, cell viability assay showed higher cytotoxicity with an IC₅₀ values of CP (500 µg/ml), Fe₃O₄ NPs (500 µg/ml) and Chitosan@CP@Fe₃O₄ NPs (500 µg/ml). The chromosomal level nano-bio interaction was studied in human blood chromosomal aberration assay, onion root tip geno-toxicity assay. The results show that Fe₃O₄ NPs are induced more cytotoxicity and genotoxicity at higher concentrations, but CP only induced genotoxicity. The combination of chitosan@CP@Fe₃O₄ NPs induced very less cytotoxicity, genotoxicity and more anti-tumor effects.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}