Journal of Cluster Science最新文献

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Simple Preparation of Waste Boron Nitride/C3N4 Composites and Simulated Solar Photocatalytic Performance 废弃氮化硼/C3N4 复合材料的简单制备及模拟太阳能光催化性能
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-08-07 DOI: 10.1007/s10876-024-02674-1
Liang Cui, Wangxi Zhang, Xinyang Zheng, Shikai Zhao, Baoyan Liang, Mingli Jiao
{"title":"Simple Preparation of Waste Boron Nitride/C3N4 Composites and Simulated Solar Photocatalytic Performance","authors":"Liang Cui, Wangxi Zhang, Xinyang Zheng, Shikai Zhao, Baoyan Liang, Mingli Jiao","doi":"10.1007/s10876-024-02674-1","DOIUrl":"https://doi.org/10.1007/s10876-024-02674-1","url":null,"abstract":"<p>In industrial production, the preparation of cubic boron nitride (cBN) under high temperature and pressure wastes a large amount of unreacted hexagonal boron nitride (hBN). This study aims to use this BN waste (wBN) as a raw material, composite it with g-C<sub>3</sub>N<sub>4</sub> to construct wBN/g-C<sub>3</sub>N<sub>4</sub> composites, and apply the composites in the field of photocatalysis. wBN/g-C<sub>3</sub>N<sub>4</sub> composites were prepared by simple calcination using wBN and ammonium cyanide as raw materials. Results showed that a heterogeneous structure was formed in the composite photocatalyst, with a decrease in its bandgap width and a significant increase in its ability to absorb light. The simulated sunlight photocatalytic activity of composite photocatalysts was significantly better than that of single wBN or g-C<sub>3</sub>N<sub>4</sub>. The photocatalytic performance of B2 sample, composed of a 4:3 ratio of wBN and melamine in the raw materials, demonstrated the highest efficiency. Under simulated solar illumination, it was capable of degrading 99.3% of MB within 60 min. The experimental results with additional capture agents indicated that the main reactive species of the composite photocatalyst were superoxide radicals (·O<sub>2</sub><sup>−</sup>) and holes (h<sup>+</sup>).</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyaniline Titanium (IV) Tungstomolybdate Composite Ion Exchanger: Fabrication and Binary Separation Studies for the Removal of Selected Toxic Heavy Metals 聚苯胺钛(IV)钨钼酸盐复合离子交换剂:用于去除某些有毒重金属的制造和二元分离研究
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-08-07 DOI: 10.1007/s10876-024-02673-2
Amane Gishere, Endale Teju, Abi M. Taddesse
{"title":"Polyaniline Titanium (IV) Tungstomolybdate Composite Ion Exchanger: Fabrication and Binary Separation Studies for the Removal of Selected Toxic Heavy Metals","authors":"Amane Gishere, Endale Teju, Abi M. Taddesse","doi":"10.1007/s10876-024-02673-2","DOIUrl":"https://doi.org/10.1007/s10876-024-02673-2","url":null,"abstract":"<p>Environmental pollution by toxic heavy metals is increasing at an alarming rate which demands the development of an appropriate analytical method to investigate and quantify the target analytes. In response to this call, polyaniline Titanium (IV) tungstomolybdate (PANI/TWM) nanocomposite was synthesized by incorporating polyaniline into Titanium (IV) tungstomolybdate using sol–gel method. The material was then characterized using X-ray diffraction (XRD), UV-Vis, Fourier transform infrared (FTIR), Thermogravimetric analysis (TGA-DTA), and Scanning electron microscope (SEM-EDX). It was amorphous with appreciable thermal stability as it retained 65.2% of its ion exchange capacity (IEC) up to 600 <sup>O</sup>C. It acts as a bifunctional strong acid cation exchanger with an IEC of 1.58 meq/g for Na<sup>+</sup> ions. Moreover, the high distribution coefficients (Kd) of 1572 and 928 mL/g for Pb(II) and Co(II), respectively, indicate its potential to treat these ions in an aqueous matrix selectively. Real sample treatment with the prepared material was undertaken for binary separation of selected metal ions in column mode and practically appreciable efficiency (90.3 to 96.8%) was achieved. Therefore, the synthesized material can be considered as a promising cation exchanger to treat an environmental matrix containing toxic heavy metals.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diclofenac Sodium and Gentamicin Co-Encapsulated PLGA Nanoparticles: Targeting Extracellular Matrix Components to Combat Biofilm Formation in Pseudomonas aeruginosa PAO1 双氯芬酸钠和庆大霉素共包封聚乳酸(PLGA)纳米颗粒:靶向细胞外基质成分对抗铜绿假单胞菌 PAO1 的生物膜形成
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-08-05 DOI: 10.1007/s10876-024-02675-0
Edris Mazloumi Jourkouyeh, Mahya Taslimi Eshkalak, Mohammad Faezi Ghasemi, Hossein Zahmatkesh, Behnam Rasti, Hojjatolah Zamani
{"title":"Diclofenac Sodium and Gentamicin Co-Encapsulated PLGA Nanoparticles: Targeting Extracellular Matrix Components to Combat Biofilm Formation in Pseudomonas aeruginosa PAO1","authors":"Edris Mazloumi Jourkouyeh, Mahya Taslimi Eshkalak, Mohammad Faezi Ghasemi, Hossein Zahmatkesh, Behnam Rasti, Hojjatolah Zamani","doi":"10.1007/s10876-024-02675-0","DOIUrl":"https://doi.org/10.1007/s10876-024-02675-0","url":null,"abstract":"<p>Non-steroidal anti-inflammatory drugs (NSAIDs) have received attention to be used in combination with antibiotics in antibacterial chemotherapy. However, this study is the first to explore the impact of dual encapsulation of diclofenac sodium and gentamicin within PLGA nanoparticles (DS-GEN-PLGA NPs) on inhibiting extracellular matrix components and biofilm eradication of <i>Pseudomonas aeruginosa</i> PAO1. DS-GEN-PLGA NPs were prepared using the double emulsion solvent evaporation (DESE) technique and characterized by various characterization techniques. Subsequently, the inhibition and eradication potential of DS-GEN-PLGA NPs against <i>P. aeruginosa</i> biofilm was explored. The DS-GEN-PLGA NPs are spherical and oval and 80–200 nm in diameter. DS-GEN-PLGA NPs significantly reduced biofilm formation by 76.28%, biofilm metabolic level by 69.8%, biofilm exopolysaccharide by 75.3%, alginate production by 32.56%, and eDNA release by 60.2%. The expression level of the <i>lasI</i> and <i>rhlI</i> decreased by 0.29 and 0.44 folds compared with untreated cells. This study indicates that DS-GEN-PLGA NPs have promising antibiofilm activity against <i>P. aeruginosa</i>, highlighting its potential as a novel therapeutic formulation to combat biofilm-related infections.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Numerical Simulation of Early Detection of Cancer Cells Using a D-Shaped Fiber-Optic Biosensor Based on Surface Plasmon Resonance 利用基于表面等离子体共振的 D 形光纤生物传感器早期检测癌细胞的数值模拟
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-08-03 DOI: 10.1007/s10876-024-02677-y
Ahmed Akouibaa, Abdelilah Akouibaa, Rachid Masrour, Mabrouk Benhamou, Abdellah Rezzouk, Heryanto Heryanto
{"title":"Numerical Simulation of Early Detection of Cancer Cells Using a D-Shaped Fiber-Optic Biosensor Based on Surface Plasmon Resonance","authors":"Ahmed Akouibaa, Abdelilah Akouibaa, Rachid Masrour, Mabrouk Benhamou, Abdellah Rezzouk, Heryanto Heryanto","doi":"10.1007/s10876-024-02677-y","DOIUrl":"https://doi.org/10.1007/s10876-024-02677-y","url":null,"abstract":"<p>The phenomenon of surface plasmon resonance (SPR) has attracted a lot of attention in recent years due to its potential applications in various fields, including biology, chemistry, materials physics and sensing technologies. In particular, SPR is used in optical devices, sensors and optoelectronic devices because of its sensitive and selective sensing capabilities. In this paper, we have used a numerical approach based on the finite element method (FEM) to study the performance of a highly sensitive D-shaped optical fiber biosensor, exploiting SPR, for the early detection of cancer in individual living cells. The sensitive part of the proposed biosensor consists of a thin layer of gold (Au) covered by a layer of titanium dioxide TiO<sub>2</sub>. Our numerical analysis aims to find the optimum design and handling parameters for detecting three types of cancer, namely breast cancer MDA-MB-231, MCF-7 and skin cancer (basal cells). To achieve this goal, we modeled the sensor’s sensitivity to the change in refractive index of the surrounding biological medium when introduced into healthy human cells and their cancerous counterparts. Our results show that the maximum sensitivity of the proposed sensor reaches the values of <span>(2017 nm.,RIU^{ - 1})</span>, <span>(2016 nm.,RIU^{ - 1})</span> and <span>(1571 ,nm.,RIU^{ - 1})</span> respectively when used for the detection of MDA-MB-231, MCF-7 and Basal cell cancers. RI resolution is estimated at <span>(4,96.10^{ - 6} RIU)</span> for MDA-MB-231 and MCF-7, while for Basal cell it is estimated at <span>(6,37.10^{ - 6} RIU)</span>.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141885153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of the Toxicity and Side Effects of Nucleic Acid-based Bio/Nanomaterials 核酸类生物/纳米材料的毒性和副作用综述
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-08-02 DOI: 10.1007/s10876-024-02665-2
Hadi Zare-Zardini, Farzaneh Yazdi, Hossein Soltaninejad, Elaheh Aghaei, Masoud Momayezolashjar, Ashraf Alemi, Adel Ghorani-Azam, Mahsa Movahhed, Setare Sadeghi, Elham Zare-Zardini, Seyed-Ahmad Mohammadi, Fatemeh Ghadiri
{"title":"A Review of the Toxicity and Side Effects of Nucleic Acid-based Bio/Nanomaterials","authors":"Hadi Zare-Zardini, Farzaneh Yazdi, Hossein Soltaninejad, Elaheh Aghaei, Masoud Momayezolashjar, Ashraf Alemi, Adel Ghorani-Azam, Mahsa Movahhed, Setare Sadeghi, Elham Zare-Zardini, Seyed-Ahmad Mohammadi, Fatemeh Ghadiri","doi":"10.1007/s10876-024-02665-2","DOIUrl":"https://doi.org/10.1007/s10876-024-02665-2","url":null,"abstract":"<p>Recently, the multidisciplinary field of nanotechnology has garnered significant interest due to its diverse applications. Among the contemporary branches of nanotechnology, DNA nanobiotechnology has emerged as a captivating area of study, combining the principles of nanotechnology with oligonucleotides. This innovative science employs a variety of nucleotide structures, including aptamers, siRNAs, antisense oligonucleotides, and others. In this investigation, we conducted a comprehensive review of the hazards and challenges associated with DNA nanobiotechnology. Despite the numerous advantages of DNA and RNA oligonucleotides, their utilization may elicit adverse effects in plants and animals. Our literature review revealed that these oligonucleotides can trigger a range of detrimental reactions, such as intense immune system stimulation, induction of cell death, pro-inflammatory responses, vascular damage, kidney damage, anticoagulant effects, inhibition of bone marrow hematopoiesis, prevention of protein synthesis, alteration of gene expression, allergic reactions, leukopenia, hyperplasia, tissue accumulation, development of new toxins and allergens, emergence of antibiotic-resistant strains, and challenges pertinent to the food industry. Given the findings of our review, it is crucial for researchers to not only focus on the positive aspects of DNA nanobiotechnology but also to consider the potential negative consequences of this scientific domain.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141885151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and Characterization of Copper Ferrite Functionalized Graphitic Carbon Nitride Nanocomposite as an Effective and Reusable Catalyst for Synthesis of Spirooxindol Quinazolinone Derivatives 铁氧体铜功能化氮化石墨碳纳米复合材料的制备与表征--一种用于合成螺吲哚喹唑啉酮衍生物的有效且可重复使用的催化剂
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-08-02 DOI: 10.1007/s10876-024-02671-4
Raheleh Shaabani, Hossein Naeimi
{"title":"Preparation and Characterization of Copper Ferrite Functionalized Graphitic Carbon Nitride Nanocomposite as an Effective and Reusable Catalyst for Synthesis of Spirooxindol Quinazolinone Derivatives","authors":"Raheleh Shaabani, Hossein Naeimi","doi":"10.1007/s10876-024-02671-4","DOIUrl":"https://doi.org/10.1007/s10876-024-02671-4","url":null,"abstract":"<p>In this research, CuFe<sub>2</sub>O<sub>4</sub>/g-C<sub>3</sub>N<sub>4</sub> nanocomposite was fabricated and characterized by using various techniques including FT-IR, XRD, EDX, VSM and FE-SEM. Furthermore, the prepared nanocomposite was applied as a highly effective, heterogeneous and recyclable catalyst for multicomponent synthesis of spirooxindole derivatives as target heterocyclic compounds. Additionally, the current research was shown unique advantages such as; simple synthesis of the catalyst, remarkable magnetic properties, convenient separation of the catalyst using a permanent magnet and the application of cheap and available precursors. In this reaction, it was gained the high yields of products and short reaction times. These results indicate the strong catalytic performance of the catalyst that was prepared.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141887130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in Nano-Mediated Biosensors: Targeting Cancer Exosome Detection 纳米生物传感器的进展:以癌症外泌体检测为目标
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-08-02 DOI: 10.1007/s10876-024-02676-z
Abhay Dev Tripathi, Yamini Labh, Soumya Katiyar, Vivek K. Chaturvedi, Pooja Sharma, Abha Mishra
{"title":"Advancements in Nano-Mediated Biosensors: Targeting Cancer Exosome Detection","authors":"Abhay Dev Tripathi, Yamini Labh, Soumya Katiyar, Vivek K. Chaturvedi, Pooja Sharma, Abha Mishra","doi":"10.1007/s10876-024-02676-z","DOIUrl":"https://doi.org/10.1007/s10876-024-02676-z","url":null,"abstract":"<p>Cancer-derived exosomes, a subset of extracellular vesicles, carry vital information about tumor progression, metastasis, and drug resistance, making them attractive targets for cancer diagnostics and therapeutics. The identification of these cancer exosomes with high sensitivity and specificity has enormous promise for early diagnosis and prognosis. Nano-mediated biological sensors are establishing themselves as innovative techniques for detecting cancer exosomes based on the distinctive physicochemical attributes of nanomaterials to improve detection sensitivity and specificity. This article presents an overview of the recent developments in nano-mediated biosensors directed particularly toward the detection of cancer exosomes. The development of ultrasensitive sensors has been enhanced by using nanomaterials such as magnetic nanoparticles, quantum dots, and gold nanoparticles. Surface modifications of these nanomaterials by conjugating the cancer-specific antibodies or aptamers facilitate target recognition and binding of cancer exosomes, thus increasing the sensitivity of detection. This review compiles different detection techniques, including SERS, Electrochemical, SPR, Chemiluminescence, and Fluorescence-based biosensor detection, in combination with different nanomaterials that are currently being researched or utilized as biosensors.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141885150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Photoluminescence of the Bi-icosahedral Au25 Nanocluster Using an Anthracene-based Fluorophore 使用蒽基荧光团增强二十面体 Au25 纳米簇的光致发光能力
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-07-30 DOI: 10.1007/s10876-024-02672-3
Dariush Aligholizadeh, Zaid Shahzad Qureshi, Desmond Smith, Benjamin Raufman, Nathaniel Stevens, Nicole Hondrogiannis, Keith Reber, Mary Sajini Devadas
{"title":"Enhanced Photoluminescence of the Bi-icosahedral Au25 Nanocluster Using an Anthracene-based Fluorophore","authors":"Dariush Aligholizadeh, Zaid Shahzad Qureshi, Desmond Smith, Benjamin Raufman, Nathaniel Stevens, Nicole Hondrogiannis, Keith Reber, Mary Sajini Devadas","doi":"10.1007/s10876-024-02672-3","DOIUrl":"https://doi.org/10.1007/s10876-024-02672-3","url":null,"abstract":"<p>Fluorescent molecules have enabled single-molecule detection of toxins, biomarkers, and pollutants under controlled conditions. Unfortunately, these fluorophores are typically organic molecules that degrade or become photobleached when applied to non-ideal systems. Noble metal nanoclusters, in particular gold nanoclusters (AuNCs), pose a solution to the problems of degradation and photobleaching. Despite the low fluorescence quantum yield of AuNCs without thiolated ligands, labeling these clusters with fluorescent ligands allows enhancement of the fluorescence intensity and manipulation of the emission wavelength. In this work, we explore the labeling of the bi-icosahedron Au<sub>25</sub> (bi-Au<sub>25</sub>) nanocluster. The bi-Au<sub>25</sub> nanocluster has unique stability and electrochemical properties making it an attractive, yet poorly studied, candidate for fluorescent labeling. In order to demonstrate its potential as a near-IR emitting nanocluster we synthesized and labeled the bi-Au<sub>25</sub> with the novel fluorophore 6-(9-Anthryl)-5-hexyne-1-thiol, or simply anthracenethiol. Two common ligands used in the synthesis of bi-Au<sub>25</sub> are hexanethiol and phenylethanethiol, and we spectroscopically verify the ability for the straight-chain alkane hexanethiol to block the labeling of bi-Au<sub>25</sub>, while the aromatic phenylethanethiol enables the labeling of the complex. These products are characterized with square wave voltammetry, UV-vis and fluorescence spectrophotometry, and NMR spectrometry. The fluorescently labeled bi-Au<sub>25</sub> nanocluster demonstrates a 25x increase in NIR photoluminescence at ~ 810 nm when originally capped with phenylethanethiol, and not the long-chain alkanethiol. The quantum yield of this cluster has been improved from 0.0786% in the unlabeled cluster to 1.97% in the labeled product.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141863287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of Anti-Inflammatory Activity of Curcumin Through Hyaluronic Acid Decorated Niosomal Nanoparticles for Effective Treatment of Rheumatoid Arthritis Patients 通过透明质酸装饰的纳米口腔颗粒增强姜黄素的抗炎活性以有效治疗类风湿关节炎患者
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-07-30 DOI: 10.1007/s10876-024-02667-0
Nasreen Ghalib Obeaid, Fadhil Jawad Al-Tu’ma, Ali Mohammed Kadhim Majeed
{"title":"Enhancement of Anti-Inflammatory Activity of Curcumin Through Hyaluronic Acid Decorated Niosomal Nanoparticles for Effective Treatment of Rheumatoid Arthritis Patients","authors":"Nasreen Ghalib Obeaid, Fadhil Jawad Al-Tu’ma, Ali Mohammed Kadhim Majeed","doi":"10.1007/s10876-024-02667-0","DOIUrl":"https://doi.org/10.1007/s10876-024-02667-0","url":null,"abstract":"<p>Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint pain, swelling, and erosion, affecting approximately 0.5-1.0% of the global population. Nanomedicine offers a promising approach for targeted rheumatoid arthritis therapy by utilizing modified nanoparticles for treatment, diagnosis, and targeted delivery in RA management. In this study, we aimed to enhance the bioavailability of curcumin, an anti-rheumatoid agent, using niosomal nanoparticles (NPs) coated with hyaluronic acid for targeted delivery to rheumatoid cells. Peripheral blood mononuclear cells were isolated from blood samples of rheumatoid arthritis patients and healthy individuals. The Hyalo-Nio-curcumin NPs were synthesized using the thin-film method. The drug release pattern of curcumin was studied, and these NPs were examined using dynamic light scattering (DLS), scanning electron microscopy (SEM), atomic force microscopy (AFM), and fourier transform infrared spectroscopy (FT-IR) techniques. Various factors such as superoxide dismutase) SOD), interleukin-1 beta) IL-1β, (interleukin-6) IL-6, interleukin-10 (IL-10), malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx), tissue inhibitor of metalloproteinases 2 (TIMP2), matrix metalloproteinase 2 (MMP2), and receptor activator of nuclear factor kappa-Β ligand (RANKL) were assessed in peripheral blood mononuclear cells. The synthesized Hyalo-Nio-curcumin NPs exhibited a spherical morphology with sizes of 179 ± 21.6 nm, a polydispersity index of 0.596, and a zeta potential of − 28.1 ± 6.3. FT-IR analysis confirmed the effective encapsulation of substances within the Hyalo-Nio-curcumin NPs. Treatment with Hyalo-Nio-curcumin NPs led to a significant reduction in MDA, as well as decreased activity of pro-inflammatory cytokines (IL-1β, IL-6) and downregulation of inflammation-related genes (MMP2, RANKL). Conversely, there was an increase in the activity of IL-10, CAT, GPx, SOD, and gene expression of TIMP2. This study demonstrates the significant potential of hyaluronic acid-coated niosomal curcumin nanoparticles in enhancing the bioavailability and therapeutic efficacy of curcumin for RA treatment. The novel use of these targeted NPs resulted in substantial anti-inflammatory and antioxidant effects, suggesting a promising approach for improving RA management through nanomedicine.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141863131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic Mesoporous Silica Functionalized with Amine Groups for Efficient Removal of Heavy Metals and Bacterial Inhibition 用胺基团功能化的磁性介孔二氧化硅可高效去除重金属和抑制细菌生长
IF 2.8 4区 化学
Journal of Cluster Science Pub Date : 2024-07-30 DOI: 10.1007/s10876-024-02669-y
Fahimeh Salari Goharrizi, S. Yousef Ebrahimipour, Hadi Ebrahimnejad, S. Jamilaldin Fatemi
{"title":"Magnetic Mesoporous Silica Functionalized with Amine Groups for Efficient Removal of Heavy Metals and Bacterial Inhibition","authors":"Fahimeh Salari Goharrizi, S. Yousef Ebrahimipour, Hadi Ebrahimnejad, S. Jamilaldin Fatemi","doi":"10.1007/s10876-024-02669-y","DOIUrl":"https://doi.org/10.1007/s10876-024-02669-y","url":null,"abstract":"<p>This study investigates the development of magnetic mesoporous silica functionalized with amine groups (MMS-NH<sub>2</sub>) for its combined capability in heavy metal removal and bacterial inhibition, aiming to address critical water treatment challenges. MMS-NH<sub>2</sub> was successfully synthesized and meticulously characterized using various techniques: Field Emission Scanning Electron Microscopy (FESEM) for morphology, Brunauer-Emmett-Teller (BET) analysis for surface area and porosity, X-ray diffraction (XRD) for crystallinity, Fourier Transform Infrared (FTIR) spectroscopy for functional group identification, Thermogravimetric Analysis (TGA) for thermal stability, and Vibrating Sample Magnetometry (VSM) for magnetic properties. The removal efficiency of five common heavy metals (Pb(II), Cu(II), Ni(II), Hg(II), and Cd(II)) from water using MMS-NH<sub>2</sub> was investigated. influence of adsorbent dosage (0.05–2 g.L<sup>− 1</sup>), solution pH (2–10), and initial metal ion concentration (50–200 mg.L<sup>− 1</sup>) on the adsorption process was systematically investigated, revealing optimal conditions for each metal ion. Isotherm models (Langmuir, Freundlich, Dubinin-Radushkevich) were employed to understand the adsorption mechanism, indicating a favorable and monolayer chemisorption process. Kinetic models (pseudo-first-order, pseudo-second-order, Elovich) were used to study the adsorption kinetics, suggesting a rapid and chemisorption-controlled mechanism. Thermodynamic parameters (ΔG°, ΔH°, and ΔS°) were calculated, confirming the spontaneous and exothermic nature of the adsorption process. Furthermore, the antibacterial activity of MMS-NH<sub>2</sub> was investigated against both Gram-negative (<i>Escherichia coli</i>) and Gram-positive (<i>Staphylococcus aureus</i>) bacteria. The results demonstrated significant inhibition rates, ranging from 70 to 90%, for both bacterial strains. The amine group functionalization is attributed to enhancing both heavy metal adsorption capacity and bacterial inhibition.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141863128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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