T. Prabhuraj, Abimannan Gomathi, Arumugam Priyadharsan, Murni Handayani, Sabah Ansar, K. A. Ramesh Kumar, Palanisamy Maadeswaran
{"title":"Design of a High-Performance WO3/g-C3N4 Z-Scheme Photocatalyst for Effective Phenol Degradation and Antibacterial Activity","authors":"T. Prabhuraj, Abimannan Gomathi, Arumugam Priyadharsan, Murni Handayani, Sabah Ansar, K. A. Ramesh Kumar, Palanisamy Maadeswaran","doi":"10.1007/s10876-024-02692-z","DOIUrl":"https://doi.org/10.1007/s10876-024-02692-z","url":null,"abstract":"<p>An innovative Z-scheme WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was efficiently produced via a straightforward hydrothermal method and applied to the photodegradation of phenol. The physiochemical behaviours of WO<sub>3</sub>, g-C<sub>3</sub>N<sub>4</sub>, WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was analyzed by various analytical instruments. Compared to WO<sub>3</sub>, g-C<sub>3</sub>N<sub>4</sub> single counterparts WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> Composite exhibits superior charge carriers’ separation efficiency and also Z scheme mechanism promoted the superior pollutant degradation. Subsequently, the WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite achieving 93% with rate constant 0.0184 min<sup>− 1</sup> phenol removal within 100 min. The noteworthy increased photocatalytic bustle of WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was attributed to the synergetic effect between the boundary of WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub>. Curiously, WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite validates exceptional photostability during reusable experiment, accentuating its potential as a functioning photocatalyst for phenol removal. The antimicrobial tests showed that the developed photocatalyst effectively sterilizes both gram-positive <i>Staphylococcus aureus</i> and gram-negative <i>Escherichia coli</i>. Thus, the WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> nanocomposites are robust materials suitable for use as antimicrobial agents and photocatalysts activated by sunlight.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing Autonomous Nanomedicine: Bridging the Gap from Concept to Potential Clinical Studies","authors":"Diya Pratish Chohan, Bipasa Dey, Arshia Tarkunde, Vaishnavi Vyas, Srijita De Sarkar, Babitha Kampa Sundara","doi":"10.1007/s10876-024-02691-0","DOIUrl":"https://doi.org/10.1007/s10876-024-02691-0","url":null,"abstract":"<p>Autonomous nanomedicine, a burgeoning field within nanotechnology and biomedical sciences, is poised to revolutionize healthcare by eliminating the need for external intervention in targeted applications within the body. This article elucidates the promise and challenges of autonomous nanomedicine, emphasizing its ability to overcome the limitations of traditional methods such as chemotherapy and radiotherapy. Central to its efficacy are nano-sized carriers, which autonomously navigate the body to deliver therapeutic agents with precision and control. By integrating automated nanoscale tools into disease detection processes, this technology offers swift and personalized assessments, reshaping disease management paradigms. To advance the clinical translation of autonomous nanomedicine, rigorous preclinical studies are imperative. However, challenges persist in ensuring reproducibility and safety, hindering progress in clinical trials. This article examines current studies with potential clinical translation, shedding light on the regulatory and ethical considerations crucial for its safe implementation. As the field progresses, maintaining a balance between innovation and safety remains paramount for harnessing the full potential of autonomous nanomedicine while safeguarding patient well-being.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Theoretical Prediction of the Smallest Sized Tricyclic-Boron Oxide B6O62+","authors":"Wen-Juan Tian, Jing-Jing Wang, Hui-Li Chen","doi":"10.1007/s10876-024-02687-w","DOIUrl":"https://doi.org/10.1007/s10876-024-02687-w","url":null,"abstract":"<p>The discovery of cyclic boron oxide clusters has prompted investigations into their distinctive structures and bonding characteristics. Notably, the majority of reported cyclic boron oxide structures consist predominantly of four to six-membered rings. In this study, we employ theoretical methods to predict the global-minimum (GM) structure of B<sub>6</sub>O<sub>6</sub><sup>2+</sup>. Our analyses, including global-minimum searches and calculations using B3LYP, PBE, PBE0, and single-point CCSD(T), reveal that the <i>D</i><sub>2<i>h</i></sub> B<sub>6</sub>O<sub>6</sub><sup>2+</sup> (<sup>1</sup>A<sub>g</sub>) configuration represents a planar and tricyclic structure, resulting from the fusion of B<sub>3</sub>O<sub>2</sub>/B<sub>4</sub>O<sub>2</sub>/B<sub>3</sub>O<sub>2</sub> units. Remarkably, this structure establishes the B<sub>6</sub>O<sub>6</sub><sup>2+</sup> cluster as the smallest boron oxide cluster with a planar tricyclic motif. Further bonding analysis indicates that B<sub>6</sub>O<sub>6</sub><sup>2+</sup> is a weakly antiaromatic system with 12π delocalized electrons. The reported B<sub>6</sub>O<sub>6</sub> has a planar structure with a 6-membered B<sub>3</sub>O<sub>3</sub> ring and 6 π electrons distributed over the ring. Because of the absence of two electrons from the highest occupied molecular orbital (HOMO) of neutral B<sub>6</sub>O<sub>6</sub>, the structure of B<sub>6</sub>O<sub>6</sub><sup>2+</sup> is distinctly different from that of B<sub>6</sub>O<sub>6</sub>.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ajmal Hayat, Ismail Shah, Abdul Jabbar, Ayman Nafady, Aziz Balouch, Muhammad Raza Shah, Sayyed Ibrahim Shah, Razium Ali Soomro, Sirajuddin
{"title":"Enhanced Wound Healing Activity in Animal Model via Developing and Designing of Self-nano Emulsifying Drug Delivery System (SNEDDS) for the Co-delivery of Hesperidin and Rutin","authors":"Ajmal Hayat, Ismail Shah, Abdul Jabbar, Ayman Nafady, Aziz Balouch, Muhammad Raza Shah, Sayyed Ibrahim Shah, Razium Ali Soomro, Sirajuddin","doi":"10.1007/s10876-024-02679-w","DOIUrl":"https://doi.org/10.1007/s10876-024-02679-w","url":null,"abstract":"<p>The aim of this work is to develop a self-nanoemulsifying drug delivery system (SNEDDS) for Hesperidin (HES) and Rutin (RUT) to improve their biopharmaceutical properties. The wound healing potential of HES-RUT-SNEDDS was compared to those of pure HES suspension (HES-s), empty SNEDDS (E-SNEDDS), and standard Fusidic Acid via topical application. To produce various HES-RUT-loaded SNEDDS, aqueous phase titration was used to select cinnamon oil, Labrasol and Tween 80 (surfactants), Transcutol (co-surfactant) from a diverse pool of surfactants, oils and co-surfactants. The thermodynamic stability of HES-RUT-loaded SNEDDS was assessed by examining the globule size, surface morphology, zeta potential, polydispersity index (PDI), and percent (%) transmittance. The improved physicochemical properties of the optimized HES-RUT-SNEDDS (S-N4) formulation included particle size, zeta potential, and % transmittance. Smooth and spherical particles were discovered using Atomic Force Microscopy (AFM). These improved SNEDDS formulations demonstrated enhanced solubility and skin permeation. When compared to HES-s, E-SNEDDS, and standard fusidic acid, the optimized HES-RUT-SNEDDS demonstrated significant wound healing activity following topical application. HES-RUT-SNEDDS is a promising approach for enhancing the wound-healing potential of HES and RUT through topical administration.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yahya S. Alqahtani, Ashraf M. Mahmoud, Al-Montaser Bellah H. Ali, Mohamed M. El-Wekil
{"title":"Fluorescent Nanoprobe Utilizing Tryptophan-Functionalized Silver Nanoclusters for Enhanced Gemcitabine Detection: Optimization and Application in Real Samples","authors":"Yahya S. Alqahtani, Ashraf M. Mahmoud, Al-Montaser Bellah H. Ali, Mohamed M. El-Wekil","doi":"10.1007/s10876-024-02682-1","DOIUrl":"https://doi.org/10.1007/s10876-024-02682-1","url":null,"abstract":"<p>A new “signal-off” probe based on silver nanoclusters modified with tryptophan amino acid (TRP@Ag NCs) has been developed for the sensitive and selective fluorometric detection of the anticancer drug gemcitabine. The probe exhibits a blue-emission at 460 nm upon excitation at 320 nm. Various reaction parameters were optimized to enhance the probe’s performance. The addition of gemcitabine results in a decrease in the fluorescence emission, which is attributed to the aggregation of the TRP@Ag NCs. The interaction between the TRP@Ag NCs and gemcitabine involves multiple types of chemical bonds, including non-covalent hydrogen bonding, Van der Waals, and electrostatic forces. The fluorescence ratio (F°/F) exhibits a linear correlation with gemcitabine concentrations ranging from 0.005 to 60 µM, with a low limit of detection (LOD) of 1.7 nM (S/<i>N</i> = 3). The TRP@Ag NCs probe demonstrates high sensitivity, good selectivity, and reliability. The developed probe was successfully applied for the detection of gemcitabine in authentic samples, including pharmaceutical injections, serum, and urine, with acceptable recovery percentages and low relative standard deviation (RSD), indicating the accuracy and reliability of the probe.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Z-Scheme g-C3N4/TiO2/NiCo2O4 Heterojunctions for Efficient Photocatalytic Degradation of Rhodamine B under Visible Light Irradiation","authors":"Aws Hamza, Hassan Alshamsi","doi":"10.1007/s10876-024-02688-9","DOIUrl":"https://doi.org/10.1007/s10876-024-02688-9","url":null,"abstract":"<p>In this study, a novel Z-scheme heterojunction based on g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub>/NiCo<sub>2</sub>O<sub>4</sub> nanocomposite was synthesized using a combination of hydrothermal and ultrasonic methods and investigated the photocatalytic degradation of Rhodamine B (RhB) dye. The synthesized nanocomposite was characterized XRD, FT-IR, FE-SEM, TEM, EDS, PL, UV–Vis DRS techniques. Subsequently, various parameters such as the effect of NiCo<sub>2</sub>O<sub>4</sub> amount in the composite structure, pH, initial pollutant concentration, photocatalyst dosage, and different scavengers were investigated to determine the exact mechanism of the photocatalytic process. In different concentrations of NiCo<sub>2</sub>O<sub>4</sub>, the base value (X: 1) was determined as the optimal value in photocatalytic degradation. g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub>/NiCo<sub>2</sub>O<sub>4</sub> composite had the highest percentage of 99.5% Rh.B dye degradation in 60 min. In addition, by examining the pH, it was found that its optimal value is 7, and the rate of dye degradation in this condition is more than other materials, and the rate constant value is 0.069 min<sup>–1</sup>. In addition, the g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub>/NiCo<sub>2</sub>O<sub>4</sub> catalyst showed good performance for each reuse and retained about 82% of its initial photocatalytic activity after 5 cycles. The results indicate that photoinducd (RhB) holes play a crucial role in the photocatalytic degradation of RhB in the presence of the g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub>/NiCo<sub>2</sub>O<sub>4</sub> nanocomposite via pair Z-scheme system. In the Z-scheme system, the rapid recombination between the hole-electron pair is not observed due to the electron trapping effect of the needle-shaped NiCo<sub>2</sub>O<sub>4</sub> structure, resulting in high photocatalytic efficiency and dye degradation. Therefore, Z-scheme systems are efficient and effective for the removal of water pollutants.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tejaswini P. Patil, Arun Kumar Parthasarathy, Dhanaji B. Malavekar, JinHyeok Kim, A. Tiwari
{"title":"Optical Biosensing of SARS-CoV-2 RNA Based on Positively Charged Poly-l-Lysine Functionalized Gold Nanoparticles","authors":"Tejaswini P. Patil, Arun Kumar Parthasarathy, Dhanaji B. Malavekar, JinHyeok Kim, A. Tiwari","doi":"10.1007/s10876-024-02678-x","DOIUrl":"https://doi.org/10.1007/s10876-024-02678-x","url":null,"abstract":"","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Verma, Satheesh Selvaraj, Ankush Chauhan, R. Subbarayan, G. S. Hikku, Aaliya Ali, P. Thakur, A. Thakur
{"title":"Silver Ions Modified α-Fe2O3 Nanoparticles: An Efficient Antibacterial Agent for Multidrug Resistant Bacteria","authors":"R. Verma, Satheesh Selvaraj, Ankush Chauhan, R. Subbarayan, G. S. Hikku, Aaliya Ali, P. Thakur, A. Thakur","doi":"10.1007/s10876-024-02680-3","DOIUrl":"https://doi.org/10.1007/s10876-024-02680-3","url":null,"abstract":"","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141927350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Shabna, J. E. Shaji, S. J. Dhas, S. Suresh, Arun Aravind, Susmi Anna Thomas, V. Vinita, J. Samuel, C. S. Biju
{"title":"Correction to: Photocatalytic Degradation of Crystal Violet Using SnO2/ZnO Nanocomposite Synthesized by Facile Sol-Gel Method","authors":"S. Shabna, J. E. Shaji, S. J. Dhas, S. Suresh, Arun Aravind, Susmi Anna Thomas, V. Vinita, J. Samuel, C. S. Biju","doi":"10.1007/s10876-024-02683-0","DOIUrl":"https://doi.org/10.1007/s10876-024-02683-0","url":null,"abstract":"","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omilla Ragavan, Muhammad Nazrul Hakim Abdullah, Lai Yen Fong, Vuanghao Lim, Yoke Keong Yong
{"title":"Zinc Nanostructure: A Short Review on Phytochemicals-Mediated Biogenic Synthesis and Its Anti-Inflammatory Effects","authors":"Omilla Ragavan, Muhammad Nazrul Hakim Abdullah, Lai Yen Fong, Vuanghao Lim, Yoke Keong Yong","doi":"10.1007/s10876-024-02681-2","DOIUrl":"https://doi.org/10.1007/s10876-024-02681-2","url":null,"abstract":"<p>Chronic inflammation underpins many severe diseases, often requiring anti-inflammatory drugs that can have adverse effects. Medicinal herbs offer an alternative but suffer from poor solubility, limiting their efficacy. Nanotechnology, particularly zinc oxide nanoparticles (ZnO NPs), presents a promising solution to enhance the therapeutic potential of herbal compounds. This review examines the nature and benefits of ZnO NPs in drug delivery systems compared to other nanomaterials. It highlights the advantages of biogenic synthesis of ZnO NPs, detailing the eco-friendly formation mechanisms and common characterization methods. The anti-inflammatory effects of biosynthesized ZnO NPs over the last five years are comprehensively reviewed, with insights into their mechanisms of action. Additionally, the pharmacokinetic and toxicokinetic profiles of ZnO NPs are explored to understand their biokinetics post-drug release. In conclusion, biogenically synthesized ZnO NPs enhance the bioavailability of medicinal plant compounds, offering a compelling alternative for treating inflammatory conditions.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}