Journal of Cluster Science最新文献

{"title":"Treatment of Cervical Cancer with Tumor Homing Peptide LyP-2 Functionalized Liposome Loaded with Cisplatin and Vorinostat","authors":"Zuoping Li,&nbsp;Jiaru Zhang,&nbsp;Shiwan You,&nbsp;Jing Zhang,&nbsp;Zhenzhen Xie,&nbsp;Na Zhao,&nbsp;Shiguo Sun","doi":"10.1007/s10876-025-02827-w","DOIUrl":"10.1007/s10876-025-02827-w","url":null,"abstract":"<div><p>Neuropilin-1 (NRP-1) is overly expressed on the membrane of cervical cancer cells, which is indispensable for cell internalization. NRP-1 achieves the goal of targeting cervical cancer cells with tumor homing peptide (THPs) in C-terminal (CendR) pathway. By this feature, the ligand LyP-2 peptide of NRP-1 with high affinity (also containing CendR motif) was functionalized on the surface of liposome (Lipo@LyP-2) to mediate its tumor homing. Under TEM, Lipo@LyP-2 is a smooth global body, whose diameter was less than 200 nm. Lipo@LyP-2 showed enhanced cell uptake in cervical cancer cells associated with human papillomavirus type 16 (HPV16) by the Confocal laser scanning microscope (CLSM). In the MTT assay, Lipo@LyP-2/SAHA/CDDP loaded with cisplatin (CDDP) and vorinostat (SAHA) also showed significant toxicity via increasing pro-apoptotic factors and decreasing anti-apoptotic factors. In addition, Western blot assay found that SAHA enhanced the intra-tumoral level of MHC class I chain-associated protein A (MICA) in cervical cancer, thus enhancing the sensitivity of cervical cancer cells to cytolysis mediated by natural killer (NK) cells. These results strongly indicate that LyP-2 functionalized Lipo/SAHA/CDDP can improve the targeting of CDDP and SAHA to SiHa cells and improve the therapeutic efficiency.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Isomers and Superatomic Character of the Smallest Endohedral Azafullerene U@C27N","authors":"Zhenyao Shi,&nbsp;Xinde Li,&nbsp;Dongrun Sun,&nbsp;Peng Jin","doi":"10.1007/s10876-025-02833-y","DOIUrl":"10.1007/s10876-025-02833-y","url":null,"abstract":"<div><p>Endohedral metalloazafullerenes (EMAFs) and endohedral metalloborafullerenes (EMBFs) are nitrogen- and boron-doped carbon cages, respectively, with metallic species inside. Recent experiments have successfully synthesized U@C₂₇B as the smallest EMBF. Herein, density functional theory (DFT) calculations were conducted to systematically investigate the possible structure of its corresponding EMAF analogue, U@C₂₇N. By fully considering the relative energies at 0 K and entropy effect at high temperatures for all potential U@C₂₇N isomers, we predicted U@<i>T</i>_<i>d</i>-C₂₇N-[5,5,5] and U@<i>T</i>_<i>d</i>-C₂₇N-[5,5,6] with different nitrogen doping positions as its two major isomers. The encapsulated U atom formally adopts the highest VI oxidation state, and is effectively stabilized by the strong covalent interactions with the cage. Holding an unpaired electron on the cage, U@C₂₇N could easily dimerize. Interestingly, it maintains a superatomic state with a perfect closed-shell 1S²1P⁶1D¹⁰1F¹⁴ electronic configuration by using 32 out of 35 valence electrons in both the monomers and dimers. The novel structures and good stability promise the possible synthesis of this smallest EMAF in the experiments.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the Structural Stability of the Ligand Protected Ag Nanoclusters with 5e-8e Valence Electrons","authors":"Endong Wang,&nbsp;Yi Gao","doi":"10.1007/s10876-025-02838-7","DOIUrl":"10.1007/s10876-025-02838-7","url":null,"abstract":"<div><p>The concept of superatoms has long been used as a guide to understand the stability of clusters. However, little work has been done to compare the structural stability of ligand-protected Ag nanoclusters with the same kernel using the superatom concept. In this study, we construct six clusters based on the same Ag₁₃ kernel, including 5<i>e</i> Ag₁₇(SR)₁₂, 6<i>e</i> Ag₂₀(SR)₁₄, 6<i>e</i> Ag₁₈(SR)₁₂, 7<i>e</i> Ag₁₉(SR)₁₂(DMPA)₃, 7<i>e</i> Ag₂₅(SR)₁₈, and 8<i>e</i> [Ag₂₅(SR)₁₈]^– (where R = -CH₃, Methyl; DMPA = C₆H₁₆P₂, 1,2-Bis(dimethylphosphino)ethane). The regulation of the valence electron count is achieved by varying the outer motifs—Ag(SR)₂, Ag₂(SR)₃, Ag(SR)₃, and Ag₂(SR)₄(DMPA)—which withdraw 1, 1, 2, and 2 valence electrons from the inner kernel, respectively. The results show that the 8<i>e</i> [Ag₂₅(SR)₁₈]^– cluster, with its closed 1S²|1P⁶ electron configuration, exhibits the least structural variation, a more balanced atomic charge distribution in the kernel Ag atoms, and a relatively large HOMO-LUMO gap. This work contributes to a better understanding of the superatom concept in the context of the structure of ligand-protected Ag nanoclusters.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Evaluation of Water-Responsive Polymer-Coated Zeolite as a Synergistic Antibacterial Carrier for Essential Oil Delivery","authors":"Xinhui Peng,&nbsp;Yanshuang Shi,&nbsp;Shuai Cen,&nbsp;Minyue Jia,&nbsp;Qing Zhou,&nbsp;Weishuo Ren,&nbsp;Bingxuan Li,&nbsp;Guoqing Li,&nbsp;Yueyang Xie,&nbsp;Xingxing Dai,&nbsp;Xinyuan Shi","doi":"10.1007/s10876-025-02826-x","DOIUrl":"10.1007/s10876-025-02826-x","url":null,"abstract":"<div><p>Essential oil (EO), a promising natural antimicrobial agent, face challenges in therapeutic applications due to volatility and instability. This study presents a coated peppermint oil-zeolite composite (PO@zeolite) with dual-release functionality. Analysis of 14 zeolites revealed that the High Pressure-Ball-1 (HP-B-1) zeolite demonstrated optimal adsorption capabilities of 30.14% maximum loading, attributed to structural parameters including pore topology, surface area (&gt; 800 m²/g), and pore volume. Encapsulation through stirring processes achieved uniform EO and polymer distribution within zeolites, as confirmed by SEM and FTIR analyses. Tuning coating thickness enabled adjustable release: higher coating gain leads to more sustained release and less water-responsive burst release. Synergistic bacteriostatic effects between zeolite excipients and EOs enhanced antimicrobial efficacy against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Candida albicans</i> through adsorption mechanisms. This study demonstrates multifunctional material design concept for multifunctional carriers for economic EO delivery systems.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-Friendly CuMoO4/Bi2S3 Nanocomposites: Superior Solar-Light Catalysts for Indigo Carmine Dye Degradation and Its Antibacterial Efficacy","authors":"Ramasamy Govarthini,&nbsp;Shanmugam Vignesh,&nbsp;Elango Visithira,&nbsp;Govindasami Periyasami,&nbsp;Lalitha Gnanasekaran,&nbsp;Rajendran Ranjith,&nbsp;Thammasak Rojviroon,&nbsp;Tae Hwan Oh,&nbsp;Paramasivam Shanmugam,&nbsp;Arumugam Priyadharsan","doi":"10.1007/s10876-025-02835-w","DOIUrl":"10.1007/s10876-025-02835-w","url":null,"abstract":"<div><p>In this study, Bi₂S₃, CuMoO₄, and a novel CuMoO₄/Bi₂S₃ nanocomposite were successfully synthesized via a straightforward solvothermal and hydrothermal method. The resulting nanocomposites underwent comprehensive characterization utilizing XRD, FTIR, XPS, TEM, and UV-vis DRS techniques to elucidate their structural, chemical, morphological, and optical properties. Furthermore, the photocatalytic performance of Bi₂S₃, CuMoO₄, and the CuMoO₄/Bi₂S₃ nanocomposite was evaluated through the degradation of Indigo carmine dye (IC) under solar light irradiation. Remarkably, the CuMoO₄/Bi₂S₃ nanocomposite displayed significantly enhanced photocatalytic efficiency compared to individual Bi₂S₃ and CuMoO₄ counterparts. The CuMoO₄/Bi₂S₃ heterojunction reduces electron–hole (e^––h⁺) recombination and enhances visible light absorption, significantly improving photocatalytic degradation. Under solar light, CuMoO₄/Bi₂S₃ achieves 98% degradation efficiency, surpassing Bi₂S₃ (46%) and CuMoO₄ (53%). The investigation into photodegradation kinetics revealed adherence to the pseudo-first-order model, with the CuMoO₄/Bi₂S₃ nanocomposite demonstrating a larger rate constant than Bi₂S₃ and CuMoO₄, affirming its superior photocatalytic activity. Additionally, the photostability of the CuMoO₄/Bi₂S₃ nanocomposite was explored, and a plausible photocatalytic mechanism was proposed. The antibacterial activity was tested against <i>Staphylococcus aureus</i> (<i>S.aureus</i>) and <i>Escherichia coli</i> (<i>E.coli</i>). The findings suggest promising ways for employing these composite materials in various environmental remediation and energy conversion applications.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria-Targeted Nanoparticles and their Progress in the Treatment of Cerebral Ischaemia-Reperfusion Injury","authors":"Jun Li,&nbsp;Sen Tong,&nbsp;Yi Hou,&nbsp;Ronghui Liu,&nbsp;Wenchao Hu,&nbsp;Song Tao,&nbsp;Hong Huang,&nbsp;Junzi Wu","doi":"10.1007/s10876-025-02832-z","DOIUrl":"10.1007/s10876-025-02832-z","url":null,"abstract":"<p>Therapeutic strategies targeting mitochondria, which is at the centre of cellular energy metabolism and a significant source of reactive oxygen species, have become a particular focus in research. Advances in nanomedicine have provided new approaches for mitochondria-targeted therapies, mainly including lipophilic cations and mitochondria-targeted peptides. However, in cerebral ischaemia–reperfusion injury (CIRI), targeted treatment is more complex due to the presence of the blood–brain barrier. This topic has emerged as a critical area of research. This review introduces the common strategies of mitochondrial targeting, focuses on the targeting role and overall efficacy of mitochondria-targeted nanoparticles in CIRI models and finally analyses the advantages and potential shortcomings of this therapeutic strategy in CIRI. This article provides a valuable theoretical basis and useful research ideas for the further development and optimisation of mitochondria-targeted nanotherapeutic strategies for CIRI.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Single-Step Biofabrication of Silver Nanocrystals UsingNaregamia Alata: A Cost Effective and Eco-Friendly Control Tool in the Fight against Malaria, Zika Virus and St. Louis Encephalitis Mosquito Vectors","authors":"Raja Mohamed Sait Thameem Azarudeen,&nbsp;Marimuthu Govindarajan,&nbsp;Abubucker Amsath,&nbsp;Udaiyan Muthukumaran,&nbsp;Giovanni Benelli","doi":"10.1007/s10876-025-02844-9","DOIUrl":"10.1007/s10876-025-02844-9","url":null,"abstract":"","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vincristine Loaded Bioinspired Vesicles: Preparation, Characterization and In-Vitro Evaluation on U87-MG Cells","authors":"Reetika Tandon,&nbsp;Mayank Handa,&nbsp;Rahul Shukla,&nbsp;Nidhi Srivastava","doi":"10.1007/s10876-025-02807-0","DOIUrl":"10.1007/s10876-025-02807-0","url":null,"abstract":"<div><p>Proposed work is focused on isolation of nanovesicles from <i>Catharanthus roseus</i> flower and Vincristine loading in it and exploration of biological activity in U87-MG and C6 cells. Nanovesicles (CDNs) were isolated by differential centrifugation followed by ultracentrifugation. Tween 80 employed as stabilizer to reduce agglomeration of particles. Spherical morphology and lipid bilayer confirmation by HRTEM. The size, PDI, and zeta potential of stable CDNs were ~ 80 nm, 0.2, and − 20 mV, respectively. The DL and EE were 12.4% and 84.6%, respectively. FTIR and DSC studies confirm encapsulation of Vincristine within CDNs. In vitro release of Vincristine from CDNs was found to follow Higuchi diffusion pattern. Drug-loaded CDNs depicted prominent cytotoxicity activity in U87 and C6 cells with ~ two times in comparison to plain CDNs and free drugs. No significant cytotoxicity was observed in HEK 293 T cells. Drug-loaded CDNs depicted prominent cellular uptake in U87-MG cells after 12 h of incubation. CDNs exhibited promising antioxidant activity when studied in ROS-induced cells as well as through DPPH and FRAP assay. In conclusion, this study, for the first time, proposed the use of CDNs as drug carriers and loading of Vincristine within exosomes isolated from its source only with prominent anti-glioma activity. This duo-drug carrier combination can be a promising approach for glioma patients after prior preclinical evaluation.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Pot Hydrothermal Synthesis of ZnO@Bi2MoO6-MoS2 Ternary Nanoflower Composites for Efficient Photodegradation of Rhodamine B","authors":"P. S. Nandisha,&nbsp;S. Yallappa,&nbsp;Sudha Joseph,&nbsp;B. Umesha,&nbsp;KL Nagashree,&nbsp; Sowbhagya,&nbsp;Hala H. Abd El-Gawad","doi":"10.1007/s10876-025-02828-9","DOIUrl":"10.1007/s10876-025-02828-9","url":null,"abstract":"<div><p>Ternary heterojunction materials with well-aligned conduction (CB) and valence bands (VB) can significantly enhance photocatalytic performance. In this study, a ZnO@Bi₂MoO₆-MoS₂ (ZBM) nanoflower photocatalyst was synthesized using a one-pot hydrothermal method with urea, thiourea, and citric acid as reducing and stabilizing agents. The structure, morphology, and elemental composition of the ZBM composite were analyzed using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray (EDX) spectroscopy. Electrochemical studies, including electron impedance spectroscopy (EIS) and photocurrent measurements, confirmed the material’s strong catalytic potential. Thermal analysis (TGA-DTA) showed that the ZBM composite is stable at high temperatures. The ZnO@Bi₂MoO₆-MoS₂ ternary composite exhibited excellent photocatalytic efficiency, degrading 97.2% of RhB in 60 min with a rate constant of 0.0219 min⁻¹ at neutral pH. It maintained structural integrity after four photodegradation cycles, demonstrating good stability. The optimal catalyst dosage for RhB degradation was determined to be 30 mg. The presence of ZnO and MoS₂ improved charge separation in Bi₂MoO₆, enhancing photocatalytic activity through dual Z-Scheme and S-Scheme mechanisms. Scavenging studies revealed that using peroxide as a scavenger, along with the ZBM photocatalyst, further improved degradation efficiency by increasing the involvement of reactive species such as holes and superoxide (O₂⁻).</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Remediation of Sulfamethazine Wastewaters by Iron Doped Perylene Diimide Supramolecular Catalysts in a Visible Light Driven Photocatalytic Process: Optimization and Kinetic Approach","authors":"Ozan Can Yıldız,&nbsp;Burcu Palas,&nbsp;Gülin Ersöz","doi":"10.1007/s10876-025-02825-y","DOIUrl":"10.1007/s10876-025-02825-y","url":null,"abstract":"<div><p>The presence of pharmaceutical compounds in water sources threaten the environmental and human health due to their complex molecular structures and persistence. The release of improperly treated pharmaceutical wastewaters into aquatic medium may result in development of drug-resistant microorganisms and endocrine disruption. Sulfamethazine, as a type of sulfonamides is one of the most widely used agents particularly in veterinary medicine. Therefore, the effective removal of sulfamethazine from water is of importance. The main focus of the study is to search for an environmental solution for the removal of recalcitrant organic compounds by testing the performance of iron impregnated perylene diimide supramolecular photocatalysts (Fe/PDI) in photo Fenton-like oxidation of sulfamethazine. The interactive effects of the operating parameters were examined in the presence of Fe/PDI by using Box-Behnken Design. The optimum photo Fenton-like reaction conditions were determined as 0.45 g/L catalyst dosage, pH 3 and 6.46 mM H₂O₂ dosage. The low iron leaching (1.344 ppm) detected in the treated sulfamethazine solution indicates the stability of the catalyst and its suitability for practical applications. The kinetic studies revealed that fitting is consistent with 1st and 2nd order kinetics but literature suggests that 2nd order is likely to be correct for the sulfamethazine degradation. The activation energy was determined as 11.3 kJ/mol in the presence of Fe/PDI photocatalyst. The radical quenching tests showed that the dominant reactive species is the hydroxyl radicals. The photocatalytic activity of the Fe/PDI was tested for the removal of different pollutants under the same reaction conditions. Complete Procion Red MX-5B decolorization was achieved in 15 min and 71.2% oxytetracycline hydrochloride degradation was obtained in 120 min. Optimization studies and modeling of reaction kinetics are significant for the application of environmentally friendly and effective supramolecular catalysts and industrial wastewater treatment systems.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10876-025-02825-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}