{"title":"Selenium Nanoparticles Synthesized and Stabilized by Fungal Extract Exhibit Enhanced Bioactivity","authors":"Anmol Singh, Sumit Kumar Jaiswal, Ranjana Prakash, Hisaaki Mihara, Nagaraja Tejo Prakash","doi":"10.1007/s10876-024-02600-5","DOIUrl":"https://doi.org/10.1007/s10876-024-02600-5","url":null,"abstract":"<p>Selenium has many beneficial bioactive properties yet has a narrow therapeutic window. This problem can be addressed by selenium in nanoform or selenium nanoparticles (SeNPs). There are several chemical and physical approaches that can be employed for the synthesis of SeNPs. However, the biological route for SeNP synthesis is known to be more eco-friendly, economical, and biocompatible when assessing bioactivities. The present study demonstrates a biological approach that effectively facilitates the synthesis and stabilization of SeNPs with the help of secondary metabolites derived from endophytic fungi <i>N. guilinensis</i> i.e., NL(C)-SeNPs<b>.</b> The nanoparticles formed were characterized via various techniques i.e., UV-visible spectroscopy, FTIR, DLS, and TEM. The synthesized NL(C)-SeNPs were spherical with a size of 55 ± 7.0 nm. These capped SeNPs (NL(C)-SeNPs) show prominent bioactivity in terms of in-vitro anti-oxidant properties and anti-microbial activity on <i>Escherichia coli, Enterobacter faecalis,</i> and <i>Staphylococcus aureus</i> and antifungal activity on <i>Aspergillus niger</i> and <i>Fusarium laterium</i>. The results indicated NL(C)-SeNPs portray increased potential anti-oxidant and anti-microbial activity in a dose-dependent manner. Furthermore, their anti-cancer activity on the HepG2 cell line was also observed in a dose-dependent manner. However, additional studies related to the toxicity and synergistic effects of SeNPs, are required before their therapeutic applications</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140202264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongji Kang, Lili Yang, Yuqi Liu, Ke Su, Hao Zhang, Xiaoxue Huang, Lu Yang
{"title":"A Carboxylic-Functionalized Anderson-Type Polyoxoanion for Efficient Selective Cationic Dye Adsorption","authors":"Hongji Kang, Lili Yang, Yuqi Liu, Ke Su, Hao Zhang, Xiaoxue Huang, Lu Yang","doi":"10.1007/s10876-024-02601-4","DOIUrl":"https://doi.org/10.1007/s10876-024-02601-4","url":null,"abstract":"<p>Organic dyes can inflict environmental harm and pose risks to human health, thereby presenting challenges in their treatment within industrial wastewater. Currently, numerous research groups have conducted investigations on the adsorption of organic dyes in industrial wastewater. Herein, this work focuses on the selective adsorption approach towards dyes molecules based on an Anderson-type polyoxometalate (noted as <b>POM-1</b>) as potential adsorbent, which has been functionalized with organic ligands to enhance its negative charge. Adsorption experiments revealed that <b>POM-1</b> displayed efficient adsorption capabilities towards the cationic dye methyl blue with almost complete adsorption within 25 min, and the adsorption rate was calculated as 98%. A rapid and consecutive filtering experiments have also been performed and further proved the excellent adsorption behavior of <b>POM-1</b> towards MB.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140171011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mina Zifar, Homayon Ahmad Panahi, Maryam Daghighi Asli, Elham Moniri, Maryam Norouzzadeh Chegini
{"title":"Design and Development of Dual Responsive Nanocarrier Based on Tungsten Disulfide Nanosheets and Its Cytotoxic Effect on PC-3 Cells as an Efficient In Vitro Drug Delivery System for Flutamide","authors":"Mina Zifar, Homayon Ahmad Panahi, Maryam Daghighi Asli, Elham Moniri, Maryam Norouzzadeh Chegini","doi":"10.1007/s10876-024-02588-y","DOIUrl":"https://doi.org/10.1007/s10876-024-02588-y","url":null,"abstract":"<p>In this work, flutamide‐loaded tungsten disulfide nanosheets modified thermo-responsive polymer (N-vinylcaprolactam) were prepared as a dual responsive system for targeted delivery of flutamide to tumor cells. The prepared nanocarrier was characterized using field-emission scanning electron microscopy, atomic force microscopy, Zeta potential, Fourier-transform infrared spectroscopy, X-ray diffraction, and thermal gravimetric analyses. The behavior of flutamide sorption was investigated by non-linear isotherm models that the equilibrium data well fitted with the Langmuir model. The maximum sorption capacity of the drug as computed from the non-linear Langmuir model was 7.33 mg g<sup>–1</sup>. Moreover, the kinetics of the sorption procedure followed by the non-linear pseudo-2nd-order kinetic model with a higher regression coefficient (R<sup>2</sup> = 0.9965). The pH and temperature-responsive nanocarrier released minimal amounts (15.75%) of the drug at a simulated physiological medium (pH 7.4; T = 37 °C). In contrast, a fast release of the drug (77.52%) was shown in a simulated cancer medium at a high temperature after 6 h (pH 5.6; T = 45 °C). Furthermore, the released amounts of drug from the nanocarrier can be regulated by adjusting the near-infrared laser irradiation. Dual responsive nanocarrier shown targeted cytotoxicity towards PC-3 cells with milder cytotoxicity towards normal cells. The nanocarrier showed two-fold higher cytotoxicity under near-infrared laser irradiation in comparison to the nanocarrier without irradiation in the PC-3 cell lines. Enhanced antitumor efficacy by photo-thermal therapy was achieved with near-infrared laser irradiation. All these data suggest that the pH and temperature dual responsive nanocarrier is a biocompatible and efficient candidate for the specific delivery of flutamide to PC-3 cells and could be utilized as a prostate cancer specific drug delivery system.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140171002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sagar A. Patil, Tanjila C. Gavandi, Maithili V. Londhe, Ashwini B. Salunkhe, Ashwini K. Jadhav, Vishwajeet M. Khot
{"title":"Manganese Iron Oxide Nanoparticles for Magnetic Hyperthermia, Antibacterial and ROS Generation Performance","authors":"Sagar A. Patil, Tanjila C. Gavandi, Maithili V. Londhe, Ashwini B. Salunkhe, Ashwini K. Jadhav, Vishwajeet M. Khot","doi":"10.1007/s10876-024-02598-w","DOIUrl":"https://doi.org/10.1007/s10876-024-02598-w","url":null,"abstract":"<p>The preparation of manganese substituted iron oxide magnetic nanoparticles by polyol synthesis route. Due to the unique properties, diethylene glycol (DEG) and tri-ethylene glycol (TEG) used as a solvent in synthesis method with different volumetric variations. The structural, morphological and hyperthermic properties of prepared samples are investigated. Formation of single-phase cubic spinel lattice for all compositions confirmed by X-ray diffraction and crystallite size was found to be decreased from 20.6 ± 1.3 to 15.2 ± 1.7 nm with varying ratio of DEG/TEG. Transmission electron microscopy (TEM) analysis displayed spherical grains with an agglomeration of the MnFe<sub>2</sub>O<sub>4</sub> magnetic nanoparticles (MNPs). Heating ability of MNPs studied with an induction heating system under different magnetic field strengths at 20 kA/m and 26.6 kA/m by varying nanoparticle concentrations at fixed frequency of 278 kHz. Antimicrobial activity on <i>E. coli</i> and antifungal activity on <i>C. albicans</i> showed effectiveness of MNPs at 10 mg/mL for such activities. Additionally, ROS induction in presence of MNPs illustrates probable action against <i>E. coli</i> and <i>C. albicans</i> and as antibacterial and antifungal agent in the medical field due to ROS generation ability.It has been shown that these optimized MNPs will play multifaceted roles for magnetic hyperthermia therapy as heat mediators, and antibacterial/antifungal agents owing to their magnetic induction heating properties and biological activities.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140171140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. F. A. Rahman, Agus Arsad, Lai Yong Wei, Ai Ling Pang, S. R. Suradi
{"title":"Unveiling the Influence of Metal Oxides on Multifaceted Polypyrrole Nanocomposite Properties","authors":"A. F. A. Rahman, Agus Arsad, Lai Yong Wei, Ai Ling Pang, S. R. Suradi","doi":"10.1007/s10876-024-02597-x","DOIUrl":"https://doi.org/10.1007/s10876-024-02597-x","url":null,"abstract":"<p>The addition of metals or metal oxides (MOs) into polypyrrole (PPy) could facilitate the effective incorporation of the features of a parent component into novel nanocomposites. As such, this present study used in-situ ultrasonic-assisted chemical oxidative polymerisation (in-situ UA-COP) to synthesise MO-PPy nanocomposites using titanium dioxide (TiO<sub>2</sub>), zinc oxide (ZnO), and silicone dioxide (SiO<sub>2</sub>). The impact of MOs on the structural, morphological, thermal and electrical characteristics of the fabricated nanocomposites was then methodically analysed. The nanocomposites’ structural and chemical constitutions were ascertained by way of X-ray diffraction (XRD), and Fourier-transform infrared (FTIR) spectroscopy. The MOs were incorporated via non-covalent bonds into the PPy matrix, without significantly affecting the PPy matrix. Thermogravimetric (TGA) and differential scanning calorimetry (DSC) analyses demonstrated that TiO<sub>2</sub>-PPy was the most thermally stable, rending it is ideal for use in reactions that require high resistance to temperature. It also had the highest electrical conductivity (2.48 S/cm), which could be attributed to the conductive channels that the MO nanoparticle interconnections formed within the polymer matrix. This in-depth investigation serves to disclose the effect of different MOs on the characteristics of PPy nanocomposites. The findings of this present study also highlight the potential applications of the produced PPy nanocomposites in different fields, especially for use in sensors.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140156257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cai-Yue Gao, Qiao-Qiao Yan, Qiang Chen, Yue-Wen Mu, Si-Dian Li
{"title":"Perfect Tetrahedral B16X4 (X = P, As) as Non-metal-stabilized Borospherenes with a Truncated B16 Cage at the Center","authors":"Cai-Yue Gao, Qiao-Qiao Yan, Qiang Chen, Yue-Wen Mu, Si-Dian Li","doi":"10.1007/s10876-024-02591-3","DOIUrl":"https://doi.org/10.1007/s10876-024-02591-3","url":null,"abstract":"<p>Based on extensive global minimum searches augmented with first-principles theory calculations, we predict herein the first boron-based perfect tetrahedral clusters <i>T</i><sub><i>d</i></sub> B<sub>16</sub>P<sub>4</sub> (<b>2</b>) and <i>T</i><sub><i>d</i></sub> B<sub>16</sub>As<sub>4</sub> (<b>3</b>) which, as aromatic non-metal analogs of the experimentally observed <i>T</i><sub><i>d</i></sub> Au<sub>20</sub> (2003, <i>Science</i> <b>299</b>, 864), all contain a truncated <i>T</i><sub><i>d</i></sub> B<sub>16</sub> (<b>1</b>) cage at the center effectively stabilized by four trivalent non-metal atoms (P, As) at the corners. Detailed natural bonding orbital (NBO) and adaptive natural density partitioning (AdNDP) bonding analyses indicate that the valences of all the trivalent component atoms in these tetrahedral clusters are fully satisfied, rendering spherical aromaticity and extra stability to the systems. The IR, Raman, and photoelectron spectra (PES) of the concerned species are theoretically simulated to facilitate their characterizations in future experiments.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140151841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of Polyoxometalates-Dianhydrides Based Polyimides for Photocurrent Generation: A Combined Experimental and Computational Study","authors":"","doi":"10.1007/s10876-024-02587-z","DOIUrl":"https://doi.org/10.1007/s10876-024-02587-z","url":null,"abstract":"<h3>Abstract</h3> <p>New 2,6-bis(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetraone (2Tris@PMDA) and its polymeric hybrids with Anderson polyoxometalates (DiTA@PMDA) and with Lindquist polyoxometalates (DiTL@PMDA) have been synthesized and thoroughly characterized. Using dr. Blade's approach, TiO<sub>2</sub> based thin films of 2Tris@PMDA, DiTA@PMDA, and DiTL@PMDA have been designed to explore the adsorption study, optical activity, and photocurrent generation. The calculated electrical conductivity values for 2Tris@PMDA, DiTA@PMDA and DiTL@PMDA were 2.8 × 10<sup>3</sup> S/m−1.90 × 10<sup>3</sup> S/m, 2.7 × 10<sup>3</sup> S/m−1.7 × 10<sup>3</sup> S/m, and 2 × 10<sup>3</sup> S/m−1.65 ×10<sup>3</sup> S/m, respectively. Furthermore, computational analysis for 2Tris@PMDA, DiTA@PMDA, and DiTL@PMDA has been studied at B3LYP using 6-31 G (d, p) and LanL2DZ level of density functional theory. It indicates that the conjugation of 2Tris@PMDA with polyoxometalates makes them a suitable candidate for dye sensitized solar cell due to the charge transfer process in DiTA@PMDA and DiTL@PMDA.</p> <span> <h3>Graphical Abstract</h3> <p> <span> <span> <img alt=\"\" src=\"https://static-content.springer.com/image/MediaObjects/10876_2024_2587_Figa_HTML.png\"/> </span> </span></p> </span>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140124969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Van Dat Doan, Thi Lan Pham, Tuan Anh Nguyen, Van Cuong Bui, Xuan Minh Vu, Thi Lan Huong Nguyen, Thi My Hanh Le, Hai Khoa Le, Thanh Tung Mai, Dai lam Tran
{"title":"Activated Carbon/Fe3O4/AgNPs Nanocomposites: In situ Synthesis from Papaya Seeds and Application for Ascorbic acid Detection","authors":"Van Dat Doan, Thi Lan Pham, Tuan Anh Nguyen, Van Cuong Bui, Xuan Minh Vu, Thi Lan Huong Nguyen, Thi My Hanh Le, Hai Khoa Le, Thanh Tung Mai, Dai lam Tran","doi":"10.1007/s10876-024-02589-x","DOIUrl":"https://doi.org/10.1007/s10876-024-02589-x","url":null,"abstract":"<p>In this work, a novel papaya seed-based activated carbon/Fe<sub>3</sub>O<sub>4</sub>/AgNPs nanocomposite (MAC/Ag) was prepared via a one-pot in situ approach and used as a versatile peroxidase mimic for colorimetric detection of ascorbic acid (AA). The MAC/Ag nanocomposite exhibited enhanced peroxidase-like activity, catalyzing the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and yielding colorimetric products. By optimizing the experimental conditions, the MAC/Ag-TMB-H<sub>2</sub>O<sub>2</sub> detection platform displayed outstanding sensitivity towards AA, with an impressively low detection limit of 0.056 µM in the linear range of 25–500 µM. Notably, the platform demonstrated remarkable reusability and stability, maintaining a high level of activity even after numerous reuse cycles. The comprehensive investigation of the underlying mechanism revealed the crucial role of hydroxyl radicals. The successful quantitative analysis of AA in papaya juice verified the applicability of the MAC/Ag-TMB-H<sub>2</sub>O<sub>2</sub> assay. These findings highlight the potential of the MAC/Ag nanocomposite as a reliable and reusable detection nanozyme for AA, offering promising prospects in environmental monitoring, biomedical diagnostics, and pharmaceutical analysis.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140125114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahsa Mirzaei, S. Yousef Ebrahimipour, Maryam Mohamadi, Tayebeh Shamspur
{"title":"Targeted Drug Delivery of Quercetin to Breast Cancer Cells Using a Modified SBA-15 Mesoporous Nanostructure","authors":"Mahsa Mirzaei, S. Yousef Ebrahimipour, Maryam Mohamadi, Tayebeh Shamspur","doi":"10.1007/s10876-024-02582-4","DOIUrl":"https://doi.org/10.1007/s10876-024-02582-4","url":null,"abstract":"<p>Undesired side effects and high hydrophobicity are the main drawbacks of conventional chemotherapeutic drugs. These limitations of cancer therapies prompted the use of nanomedicine. Over the past few years, nano-based drug delivery systems have gained considerable attention for the treatment of cancer. Nanotechnology advances offer a method of delivering anticancer drugs efficiently. In this work, mesoporous silica (SBA-15) has been functionalized with (3-aminopropyl) triethoxysilane (APTES) as a carrier for the anticancer medicine quercetin. Using both van der Waals’ force and hydrogen bonds, quercetin could bind to the porous structure. In the next step, the loading of quercetin and carbon quantum dots took place. Then, polyvinylpyrrolidone (PVP) as a capping agent was used to control the release of the drug from the nano-carrier, and finally, folic acid was used to target the drug delivery. The nanocarrier-drug complexes were characterized by EDS, DLS, XRD, BET, FE-SEM, FT-IR, and UV–Vis. Also, drug release tests were performed in <i>in-vitro</i> conditions. Tests performed in buffer solution (pH 5.3) showed the best pharmaceutical availability. For healthy MCF-10A human breast epithelial cells (IC<sub>50</sub> = 53.6 M) than for human breast cancer MCF-7 cells (IC<sub>50</sub> = 13.4 M), formulations made from quercetin are much more toxic. This can be related to the presence of folic acid in the prepared formulation. The surface of cancer cells has a significantly higher number of folate receptors compared with healthy cells, so, the drug-containing formulation accumulates more heavily around cancer cells and has a bigger impact on these cells. The release index of the synthesized nano carrier exhibited the release of quercetin in applied media.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140124896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of pH-Sensitive Alendronate-Decorated Silk Fibroin/ Alginate Nanoparticles for Active Targeting of Doxorubicin to Bone Cancers","authors":"Fatemeh Vafapour, Fatemeh Bagheri, Mehdi Farokhi","doi":"10.1007/s10876-024-02593-1","DOIUrl":"https://doi.org/10.1007/s10876-024-02593-1","url":null,"abstract":"<p>Targeted drug delivery has a positive impact on the concentration of anticancer drugs at the tumor site and can reduce harmful side effects. In this research, silk fibroin and sodium alginate were utilized to produce nanoparticles, which were then targeted using sodium alendronate (SF-SA-ALN NPs) to improve the effectiveness of chemotherapy on osteosarcoma. The resulting nanoparticles had a surface charge of -50.5 mV and an average size of 252 nm (with PDI = 0.157). Doxorubicin (DOX) was loaded onto the nanoparticles using ionic interaction with 96% drug loading efficiency. The nanoparticles showed higher drug release at pH 5.4 compared to pH 7.4. It was also investigated the effectiveness of in vitro bone targeting using hydroxyapatite (HA) as a bone model, and found that targeted nanoparticles accumulated in HA crystals. The toxicity of the drug-loaded nanoparticles on a human osteosarcoma cell line (MG-63) revealed that the drug-targeted nanoparticles were more toxic than free drug after 24 h. This may be due to the presence of alendronate on the SF-SA-ALN NPs, which allowed for internalization of the nanoparticles through endocytosis. Overall, these nanoparticles show promise as a potential drug delivery system for osteosarcoma treatment.</p>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140017134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}