Journal of Cluster Science最新文献

{"title":"Synthesis of Chitosan-Modified Diclofenac Acid Prodrug Nanoparticles and Evaluation of Their Anti-Inflammatory Effects in a Preclinical Model","authors":"Shahida Muhammad Habib,&nbsp;Huma Ikram,&nbsp;Shafi Ullah,&nbsp;Abdul Jabbar,&nbsp;Saira Yasmeen,&nbsp;Muhammad Raza Shah","doi":"10.1007/s10876-024-02734-6","DOIUrl":"10.1007/s10876-024-02734-6","url":null,"abstract":"<div><p>Diclofenac acid (DA) is widely employed in various clinical settings for pain management. However, prolonged use of DA can induce various adverse effects on the gut, including ulcers and intestinal bleeding. There is also a possible link between the extended use of DA and its increased susceptibility to cardiovascular diseases. Prodrug-based nanoparticles (NPs) have emerged as a promising approach for drug delivery and overcome side effects. In this investigation, a diclofenac acid-based prodrug (DA-P) was synthesized and subsequently used for developing NPs (DA-P-NPs). The developed NPs were further modified with chitosan (DA-P-NPs-CHI) to achieve stability and sustained release of the drug. The DA-P was chemically synthesized and confirmed with EI-mass spectrometry, ¹H-NMR, and ¹³C-NMR spectroscopic techniques. The characterization of DA-P-NPs and DA-P-NPs-CHI involved several techniques, such as atomic force microscopy (AFM and SEM), DLS, FTIR, TGA, and DSC. DA-P demonstrated a reduced critical micelle concentration (CMC) of 0.07 mg/mL and effectively encapsulated more drug within the NPs. DA-P-NPs and DA-P-NPs-CHI exhibited average particle sizes of 130.7 ± 0.6 and 230.2 ± 5.3 nm, and surface charges of -36.2 ± 2.0 and 41.2 ± 0.9 mV, respectively. DA-P-NPs-CHI exhibited a drug-release rate remarkably greater at acidic pH. A paw-edema model was induced <i>via</i> formalin exposure to evaluate the anti-inflammatory effect of DA-P-NPs-CHI. Assessment of anti-inflammatory activity demonstrated that the use of DA-P-NPs-CHI resulted in a substantial reduction in edema compared to diclofenac-treated rats. These findings demonstrate that the proposed DA-P-NPs possess the promising attributes that make them a possible alternative therapy for pain and inflammation.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crafting Superior Photocatalytic Potential: Synergistic Precipitation-Hydrothermal Customization of CTAB-Engineered Co3O4 Nanoparticles","authors":"Arshdeep Kaur,&nbsp;Harpreet Kaur,&nbsp;Sanjeev Kumar,&nbsp;Prit Pal Singh,&nbsp;Kanchan Bala,&nbsp; Supreet,&nbsp;Sunil Kumar,&nbsp;Jyoti Gaur,&nbsp;Sandeep Kaushal,&nbsp;Gautam Singh","doi":"10.1007/s10876-024-02719-5","DOIUrl":"10.1007/s10876-024-02719-5","url":null,"abstract":"<div><p>This study introduces CTAB-loaded Co₃O₄ nanoparticles (NPs) as a highly efficient solution for removing Brilliant Yellow (BY), Reactive Yellow (RY) and Methyl Orange (MO) dye from contaminated water. Synthesized via a co-precipitation and hydrothermal method, these NPs were characterized using UV-Vis, FTIR, XRD, TEM, and SEM. The Co₃O₄ NPs, with a crystallite size of 11.88 nm and an average particle size of 13 nm, achieved 100% photocatalytic degradation of BY dye (120 mg/L) within 140 min. Additionally, the NPs demonstrated promising photocatalytic activity against RY and MO dyes. The synergy between CTAB and Co₃O₄ NPs enhances dye degradation, positioning them as a cost-effective and efficient solution for wastewater treatment. This work highlights the environmental potential of CTAB/Co₃O₄ NPs in addressing water pollution challenges.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZnO/PMMA Nanofibers for the Photocatalytic Water Remediation","authors":"Kinyas Polat,&nbsp;Elif Ant Bursalı,&nbsp;Mürüvvet Yurdakoç","doi":"10.1007/s10876-024-02729-3","DOIUrl":"10.1007/s10876-024-02729-3","url":null,"abstract":"<div><p>In this study, a novel ZnO/PMMA nanofiber catalyst was fabricated using electrospinning, resulting in a barbed wire-like structure that enhances photocatalytic performance. The research aimed to investigate the material’s effectiveness in degrading organic pollutants under UV light, providing a sustainable solution for water purification. Comprehensive characterization techniques, including XRD, XPS, SEM, EDS, and FTIR, were employed to analyze the crystal structure, micromorphology, and elemental composition of the catalyst. Photocatalytic degradation experiments showed that up to 91% degradation was achieved after 60 min of UV light irradiation at pH 11, with no significant bulk adsorption observed, confirming the dominance of the photocatalytic mechanism. The optimized pH of 11 was found to be ideal for achieving high degradation rates. This novel ZnO/PMMA nanofiber structure demonstrates significant potential for environmental applications, particularly in water purification, offering an efficient and sustainable approach to pollutant removal.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Gold Nanoparticles Coated with Bismuth Oxide for X-ray Computed Tomography Imaging","authors":"Soichiro Takiguchi,&nbsp;Ayumi Takahashi,&nbsp;Noriko Yamauchi,&nbsp;Shohei Tada,&nbsp;Takumu Takase,&nbsp;Mone Kimura,&nbsp;Kohsuke Gonda,&nbsp;Yoshio Kobayashi","doi":"10.1007/s10876-024-02724-8","DOIUrl":"10.1007/s10876-024-02724-8","url":null,"abstract":"<div><p>Au nanoparticles are promising X-ray contrast agents as their properties could render them useful for long-term diagnostic imaging. However, the surface modification of Au nanoparticles is necessary to improve their biocompatibility and hence, their retention in the body and contrast-enhancing ability. Therefore, in this study, we prepared a colloidal solution of Au nanoparticles coated with bismuth oxide (Bi₂O₃) under stabilization of the coated nanoparticles using polyvinylpyrrolidone (PVP) (Au/Bi₂O₃/PVP) and performed X-ray imaging of a mouse using the Au/Bi₂O₃/PVP nanoparticle colloidal solution. Au nanoparticles with a particle size of 21.9 nm were prepared by reducing Au ions (III) using sodium citrate in water at 80 °C. The Bi₂O₃ coating of the Au nanoparticles was performed in the presence of Au nanoparticles and PVP by precipitation via the reaction of Bi(NO₃)₃ and NaOH in water (Au/Bi₂O₃/PVP). The loading efficiencies of Au and Bi in the Bi₂O₃-coated Au nanoparticles were dependent on the Bi concentration in the Bi₂O₃-coating process, and were 67.2 and 61.8%, respectively, at a Bi concentration of 0.66 × 10⁻³ M. The X-ray imaging ability of the Au/Bi₂O₃/PVP nanoparticle colloidal solution was superior to that of a commercial X-ray contrast agent. One Au/Bi₂O₃/PVP nanoparticle exhibited a computed tomography value larger than that of a Au nanoparticle. The popliteal lymph node of a mouse was identified using the Au/Bi₂O₃/PVP nanoparticle colloidal solution, highlighting the possibility of accurate, long-term observation of the sentinel lymph node using this solution.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-Friendly Fabrication of Cr2V4O13 Nanoparticles: A Promising Material for Photocatalysis, Electrochemical Sensing, and Supercapacitor Applications","authors":"Vijay Dubey,&nbsp;Ketan D. Parikh,&nbsp;Ravirajsinh J. Jadav,&nbsp;Devarshi H. Vyas,&nbsp;B. Avinash,&nbsp;C. R. Ravikumar,&nbsp;A. Naveen Kumar,&nbsp;H. Seshagiri Rao,&nbsp;Deepak Kumar,&nbsp;Suresh Ghotekar","doi":"10.1007/s10876-024-02720-y","DOIUrl":"10.1007/s10876-024-02720-y","url":null,"abstract":"<div><p>The rising demand for energy and the adverse effects of pollution on the environments and human health highlight the urgent need for sustainable alternatives. Transition metal oxides are the solution to fulfill future demands. Using a green synthesis approach, this study disclosed a bio-inspired synthesis of chromium tetravanadate nanoparticles (Cr₂V₄O₁₃ NPs). The high-resolution transmission electron microscopy (HRTEM) and field-emission scanning electron microscopy (FESEM) images confirmed the nano-plate-shaped morphology, and the powder X-ray diffraction (PXRD) pattern showed that the Cr₂V₄O₁₃ NPs have a monoclinic phase with an average crystallite size of 25.89 nm. In the Fourier transform infrared (FTIR) spectrum, peaks at 802 and 717 cm^–1 are linked with the stretching bond of V–O–V, whereas peaks at 644, 524, and 482 cm^–1 are associated with Cr–O bond. The optical bandgap of Cr₂V₄O₁₃ NPs was determined using Tauc’s plot of UV-Vis. study and was found to be 2.22 eV. The photodegradation of Cango Red (CR) and Fuchsin Acid (FA) dyes under UV light irradiation was effectively facilitated by the plant-mediated Cr₂V₄O₁₃ NPs, exhibited remarkable photodegradation performance of 71.35% and 53.35% in 120 min, respectively. A carbon paste electrode immersed in 0.1N HCl solution was employed to ascertain the electrochemical features of Cr₂V₄O₁₃ NPs, resulting in the detection of ascorbic acid at a very low 1–5 µM concentration. In cyclic voltammetry evaluation, the Cr₂V₄O₁₃ NPs showed greater sensitivity at various scan rates. Ascorbic acid was finally shown to have exceptional redox reaction and ascorbic acid detection capabilities when it was used as an analyte. Additionally, the energy storage potential of Cr₂V₄O₁₃ NPs has been demonstrated by Cyclic Voltammetry (CV) and Galvanostatic Charge-Discharge (GCD) techniques, and specific capacitance was determined as 171 F/g was obtained at the most efficient 5 mV s⁻¹ scan rate having exceptional long-term cyclic stability with approximately 100% Coulombic efficiency after 2000 GCD cycles. These promising outcomes highlight the fascinating potential for high-performance uses of Cr₂V₄O₁₃ NPs with multifunctionality in diverse applications.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Removal of Cr (VI) and As (V) from Aqueous Solution Using Magnetically Separable Nickel Ferrite Nanoparticles","authors":"Ahmed Anwar Hassan,&nbsp;Yosri A. Fahim,&nbsp;Mohamed Eid M. Ali","doi":"10.1007/s10876-024-02736-4","DOIUrl":"10.1007/s10876-024-02736-4","url":null,"abstract":"<div><p>A promising nickel ferrite (NiFe₂O₄) NPs with excellent magnetic characteristics was synthesized using an aqueous-based reflux approach that eliminates the need for calcination temperature. The magnetic nanoparticles obtained were analysed using X-ray diffraction (XRD), Fourier-transform infrared (FTIR), and scanning electron microscopy (SEM). The analysis showed that synthesized nickel ferrite had a spherical shape with an average size ranging from 18 to 29 nm. The synthesized nickel ferrite is utilized for the removal of hexavalent chromium (Cr (VI)) and pentavalent arsenic (As (V)) ions from aqueous solution through adsorption method. The removal of Cr (VI) ions achieved a maximum efficiency of 65% after 120 minutes at a pH of 5, with a ferrite dose of 2 g/L and a concentration of Cr (VI) ions of 25 mg/L. while the removal of As (V) at a pH of 5, with a dose of 1 g/L of ferrite and an initial concentration of 25 mg/L of As (V) ions was 77% after 120 minutes. In addition, the data obtained from the isotherms of Langmuir (R² = 0.99, 0.98), Freundlich (R² = 0.86, 0.97) and Temkin (R² = 0.83, 0.97). The adsorption of Cr (VI) ions is governed by a pseudo first-order kinetics process, whereas the adsorption of As (V) ions is governed by a pseudo second-order kinetics reaction. After five adsorption–desorption cycles at the same optimal operating condition, Cr (VI) and As (V) removal efficiency dropped from 65%, 77% to 25%, 30%, respectively.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10876-024-02736-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Nano Zinc Oxide Particle Production and Their Antimicrobial Potentials: A Review","authors":"Perugu Ravi,&nbsp;Madhava C. Reddy,&nbsp;T. Chandrasekhar,&nbsp;Suresh V. Chinni,&nbsp;Hussaini Adam,&nbsp;Subash C. B. Gopinath,&nbsp;Veeranjaneya Reddy Lebaka","doi":"10.1007/s10876-024-02733-7","DOIUrl":"10.1007/s10876-024-02733-7","url":null,"abstract":"<div><p>Nano zinc oxide particles (ZnO-NPs) have captured significant interest from researchers worldwide due to their exceptional biological activity. These nanoparticles are known for their low toxicity and biodegradability, which enhance the bioactivity of pharmacophores. In the realms of electronics and optoelectronics, ZnO-NPs are the most widely utilized nano metal oxides, thanks to their distinctive optical properties and chemical behaviors. These properties can be easily modified through changes in morphology and a high bandgap. The synthesis of biomimetic nanoparticles from therapeutic plants, fungi, bacteria, and algae enhances their durability and biocompatibility in various biological environments. Biofabrication also affects their physicochemical behavior, which contributes to increased biological potency. This article reviews various ZnO-NP synthesis methods, including physical, chemical, and biogenic techniques, with a particular emphasis on green synthesis method. The review highlights the unique properties and mechanisms that give ZnO-NPs their powerful antimicrobial activities against a wide range of pathogens, including bacteria, fungi, and viruses. The nanoparticles’ small size, large surface area, and biocompatibility enable effective interaction with microbial cells, leading to cell death through direct interaction, the generation of reactive oxygen species (ROS), and modulation of the host immune response. Also delves advantages and disadvantages of zinc oxide nanoparticles compared to other metal oxides, as well as their limitations. The diverse properties of ZnO-NPs make them a versatile and promising option for various applications, particularly in nanomedicine. The integration of biogenic synthesis methods not only improves their ecological profile but also enhances their efficacy and safety in different biological contexts.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano–Bio Interaction and Antibacterial Mechanism of Engineered Metal Nanoparticles: Fundamentals and Current Understanding","authors":"Atul Kumar Tiwari,&nbsp;Prem C. Pandey,&nbsp;Munesh Kumar Gupta,&nbsp;Roger J. Narayan","doi":"10.1007/s10876-024-02728-4","DOIUrl":"10.1007/s10876-024-02728-4","url":null,"abstract":"<div><p>The rapid development of multidrug resistance in a wide range of microorganisms poses a significant clinical challenge for healthcare professionals treating infectious diseases. Over the last decade, research has focused on the preparation of metal-based nanomaterials with antibacterial, antiviral, and antifungal activities to combat communicable diseases. Several metal nanomaterials, such as gold, copper, silver, palladium, and metal oxides, such as titanium, zinc, and iron, have demonstrated encouraging antimicrobial properties against multidrug-resistant microorganisms. The nano–bio interaction of metal nanoparticles are particularly influenced by their physicochemical properties, including shape, size, surface charge, ligand capping, doping, pH stability, roughness, and crystal structure. Once interacting, nanoparticles exert their biocidal effects through various pathways, such as enhanced intracellular reactive oxygen species, cell membrane damage, membrane potential depolarization, DNA damage, biofilm destabilization followed by interactions with biofilm components. However, a clear understanding of the connection between the specific physicochemical properties and antimicrobial mechanisms of metal nanoparticles is lacking. Thus this comprehensive review article discusses different fundamental aspects of nano–bio interactions of metal nanoparticles with planktonic as well as biofilm form of bacteria, the associated antimicrobial mechanisms along with recent advancements and therapeutic challenges.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterometallic Ru–Ir Hydride Carbonyl Clusters","authors":"Francesca Forti,&nbsp;Cristiana Cesari,&nbsp;Marco Bortoluzzi,&nbsp;Cristina Femoni,&nbsp;Tiziana Funaioli,&nbsp;Maria Carmela Iapalucci,&nbsp;Stefano Zacchini","doi":"10.1007/s10876-024-02723-9","DOIUrl":"10.1007/s10876-024-02723-9","url":null,"abstract":"<div><p>[NEt₄][Ru₃(µ-H)(µ-CO)(CO)₁₀] (<b>1</b>) reacts with [{Ir(µ-Cl)(cod)}₂] in a 1 : 0.5 molar ratio under H₂ atmosphere affording the previously reported [NEt₄][Ru₃Ir(µ-H)₂(µ-CO)₃(CO)₉] (<b>2</b>). Performing the reaction under N₂ atmosphere with a 1 : 1 molar ratio of the reagents results in the new species [NEt₄][Ru_3–xIr_2+x(μ-H)_1–x(µ_3-CO)(µ-CO)₃(CO)₈(cod)] (x = 0.11) (<b>3</b>), whereas [Ru_3−xIr_2+x(µ-H)_2–x(µ-CO)₄(CO)₆(cod)₂] (x = 0.5 and 0.77) (<b>4</b>) is obtained by further increasing the amount of [{Ir(µ-Cl)(cod)}₂]. In particular, compound <b>4</b> with x = 0.5 has been obtained with a 1:1.25 molar ratio of the reagents, whereas <b>4</b> with x = 0.77 is formed increasing the stoichiometry to 1:1.5. Reaction of <b>1</b> and [{Ir(µ-Cl)(cod)}₂] under CO atmosphere affords [NEt₄]₂[Ru₄Ir₂(µ-CO)₅(CO)₁₂] (<b>5</b>) (molar ratio of the reagents 1:0.7). Syntheses of <b>2-5</b> are very sensitive to the experimental conditions, and optimized procedures in order to obtain each of these compounds in good yield and high purity have been identified. Slight variations of the experimental conditions lead to lower yield and traces of side-products are formed, among which [NEt₄][Ru₃Ir(µ-H)₂(µ-CO)₃(CO)₇(cod)] (<b>6</b>), [NEt₄][Ru₃Ir(µ-H)(µ-Cl)(µ-CO)₃(CO)₉] (<b>7</b>), [NEt₄]₃[Ru₂Ir₂(µ₃-H)(µ-CO)₃(CO)₉]Cl₂ (<b>8</b>) and [NEt₄]₂[Ru₄(µ₄-O)(µ-Cl)₄(µ-CO)₂(CO)₈] (<b>9</b>) have been identified by single-crystal X-ray diffraction (SC-XRD). All the main products <b>2</b>-<b>5</b> have been structurally characterized by SC-XRD and further investigated by IR and ¹H NMR spectroscopy in solution. Hydride locations have been elucidated by computational methods.</p><h3>Graphical Abstract</h3><p>Homoleptic and heteroleptic heterometallic Ru-Ir hydride carbonyl clusters have been obtained from [NEt4][Ru3(µ-H)(µ-CO)(CO)10] and [Ir(COD)Cl]2 under different experimental conditions.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Folic Acid Functionalized Carbon Nanotubes for Efficient Delivery of Curcumin and Quercetin Against Pathogenic Bacteria","authors":"Jasra Gul,&nbsp;Abdul Jabbar,&nbsp;Samina Perveen,&nbsp;Asia Naz Awan,&nbsp;Muhammad Raza Shah","doi":"10.1007/s10876-024-02725-7","DOIUrl":"10.1007/s10876-024-02725-7","url":null,"abstract":"<div><p>Drug-resistant bacteria pose an alarming risk to public health globally. Specifically, infections caused by multidrug-resistant (MDR) Gram-positive bacteria (e.g., <i>Staphylococcus aureus</i>) are an increasing global health concerns. Herein, we report the first comparative evaluation of folic acid functionalized carbon nanotubes (FA-OMC) loaded with curcumin and quercetin to enhance their efficacies against gram positive MDR <i>S. aureus</i> and <i>E. coli</i>. The carbon nanotubes were oxidized and underwent successive carbodimide coupling and passive drug entrapments to achieve the drug loaded nanocomposites, which were further characterized with TGA, PXRD, SEM, AFM, FTIR, and DLS. The drug release kinetics as well as the cytotoxic evaluation and antibacterial studies were also evaluated. The results revealed that our drug loaded nanocomposites showed high drug entrapment, wrecked layered in morphology, nano range in size, possess negative zeta potential, low PDI values, higher thermal stability and partial crystallinity. FTIR analysis of the drug loaded nanocomposites shows the possible interaction between drug and nanotubes. The developed formulations (Cur-FA-OMC and Que-FA-OMC) revealed extended drug release and higher biocompatibility against tested NIH/3T3 cells. The antimicrobial assessment of drug loaded nanoparticles against gram positive bacteria showed significant bactericidal efficacy as compared to drug alone and their morphological disruption were also confirmed by AFM microscopy. The outcomes of our study suggests that our developed drug loaded nanoformulations could be a viable option for reversing MDR bacteria. More research needed in future to consolidate these findings.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}