Udhayakeerthana Chinnathambi, Roshan Chandrapal, Aiswarya R, Baskaran Palanivel, T. Kalaivani
{"title":"Copper-Enriched Co₃O₄/MoS₂ Nanocomposites for Superior Photocatalytic Degradation of Methylene Blue under Visible Light","authors":"Udhayakeerthana Chinnathambi, Roshan Chandrapal, Aiswarya R, Baskaran Palanivel, T. Kalaivani","doi":"10.1007/s10876-024-02764-0","DOIUrl":"10.1007/s10876-024-02764-0","url":null,"abstract":"<div><p>In recent decades, the focus on building a sustainable living environment has shifted to two key goals: providing clean water and increasing the use of renewable energy. Photocatalytic processes are a possible alternative since photocatalysts are extremely successful at water purification and producing renewable energy sources. This study focuses on developing a sustainable photocatalyst for environmental remediation by synthesizing copper-doped Co<sub>3</sub>O<sub>4</sub> nanoparticles on MoS₂ nanosheets using co-precipitation method. For the first time, we report a visible-light-driven photocatalyst of Cu–Co<sub>3</sub>O<sub>4</sub>/MoS<sub>2</sub> nanocomposite for photo-Fenton-like degradation activity. The structural, morphological, surface chemical, and optical properties of the samples were deeply analyzed. The results show a significant improvement in photocatalytic performance, achieving a <b>98%</b> degradation of methylene blue dye under visible light in <b>60 minutes.</b> The enhanced efficiency is attributed to the synergistic effect of Cu–Co<sub>3</sub>O<sub>4</sub> and MoS<sub>2</sub>, which improves charge separation, increases active sites, and facilitates electron transfer. This makes the nanocomposite a promising solution for sustainable environmental remediation.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikhil C. Bhoumik, Md. Nazmul Huda, Vladimir N. Nesterov, Graeme Hogarth, Shariff E. Kabir, Jagodish C. Sarker
{"title":"Reactivity of Labile Triosmium Complexes, [Os3(CO)10(MeCN)2] and [Os3(CO)10(µ-H)2] with Tetraethylthiuram Disulfide (Disulfiram)","authors":"Nikhil C. Bhoumik, Md. Nazmul Huda, Vladimir N. Nesterov, Graeme Hogarth, Shariff E. Kabir, Jagodish C. Sarker","doi":"10.1007/s10876-024-02749-z","DOIUrl":"10.1007/s10876-024-02749-z","url":null,"abstract":"<div><p>Reactions of the anti-alcohol drug disulfiram (tetraethylthiuram disulphide = Et<sub>4</sub>TDS) with low valent triosmium complexes are described. Room temperature reaction with [Os<sub>3</sub>(CO)<sub>10</sub>(MeCN)<sub>2</sub>], affords three new open polynuclear clusters, [Os<sub>3</sub>(CO)<sub>10</sub>(S<sub>2</sub>CNEt<sub>2</sub>)<sub>2</sub>] (<b>1</b>), [Os<sub>4</sub>(CO)<sub>12</sub>{µ<sub>3</sub>-η<sup>1</sup>(C),<i>κ</i><sup>2</sup>(O,O)-CO<sub>2</sub>}(S<sub>2</sub>CNEt<sub>2</sub>)(µ-S<sub>2</sub>CNEt<sub>2</sub>)] (<b>2</b>) and [Os<sub>3</sub>(CO)<sub>9</sub>(µ<sub>3</sub>-SCNEt<sub>2</sub>){µ-SC(O)NEt<sub>2</sub>}] (<b>3</b>) together with the known mononuclear complex <i>cis-</i>[Os(CO)<sub>2</sub>(S<sub>2</sub>CNEt<sub>2</sub>)<sub>2</sub>] (<b>4</b>). All result from oxidative-addition of disulfiram to the triosmium centre, with <b>2</b> also capturing CO<sub>2</sub>, while cluster <b>3</b> has undergone further C–S bond scission and partial oxidation of one of the generated thiocarboxamide ligands. With [Os<sub>3</sub>(CO)<sub>10</sub>(µ-H)<sub>2</sub>], complexes <b>1</b> and <b>4</b> are also formed along with previously reported [Os<sub>3</sub>(CO)<sub>10</sub>(µ-S<sub>2</sub>CNEt<sub>2</sub>)(µ-H)] (<b>5</b>), [Os<sub>3</sub>(CO)<sub>9</sub>(µ<sub>3</sub>-S<sub>2</sub>CNEt<sub>2</sub>)(µ-H)] (<b>6</b>), and the new cluster, [Os<sub>3</sub>(CO)<sub>9</sub>(µ-S<sub>2</sub>CNEt<sub>2</sub>)(µ-H)] (<b>8</b>), which is an isomer of <b>6</b>. The product distribution is rationalized by completing pathways following the oxidative-addition of disulfiram. Thus, reductive-elimination of H<sub>2</sub> affords <b>1</b>, which in turn converts to <b>4</b>, while reductive-elimination of the (unstable) dithiocarbamic acid, Et<sub>2</sub>NCS<sub>2</sub>H, leads to the formation of <b>5</b>, which can further lose CO to afford isomers <b>6</b> and <b>8</b>. Heating disulfiram with [Os<sub>3</sub>(CO)<sub>12</sub>] at 110 °C predominantly affords <b>4</b>, together with smaller amounts of the novel trithiocarbamate complex, <i>cis-</i>[Os(CO)<sub>2</sub>(S<sub>2</sub>CNEt<sub>2</sub>)(S<sub>3</sub>CNEt<sub>2</sub>)] (<b>9</b>). All the compounds have been characterized by elemental analysis, IR and <sup>1</sup>H NMR spectroscopy, together with single crystal X-ray diffraction analysis of six molecules.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mujeeb ur Rehman, Seema Inayat, Hafiza Arsala, Saadat Hussain, Shagufta Noreen, Fakhar Ud Din, Rukesh Maharjan
{"title":"Nanocarrier-Mediated Enhancement of Fusidic Acid’s Anti-bacterial Activity: A Comparative Analysis of Its Niosomal and Liposomal Delivery Systems","authors":"Mujeeb ur Rehman, Seema Inayat, Hafiza Arsala, Saadat Hussain, Shagufta Noreen, Fakhar Ud Din, Rukesh Maharjan","doi":"10.1007/s10876-024-02746-2","DOIUrl":"10.1007/s10876-024-02746-2","url":null,"abstract":"<div><p>Biofilms are group of bacteria that are protected by a slimy layer. These biofilms are more resistant to antibiotics than individual bacteria which are the basic building blocks of biofilms. Researchers are actively introducing new treatments that are supposed to be more efficient in fighting biofilms and to be less toxic to the patient than the conventional antibiotics. Here in this study we propose the development of Fusidic acid (FA) loaded liposomes and niosomes to improve the anti-bacterial activity <i>in-vitro</i> against <i>Staphylococcus aureus</i> strains. The designed niosomes and liposomes of FA were smaller in size ranging from 116.4 to 274.2 nm displaying homogeneity in terms of size distribution with PdI <span>(le 0.4)</span> 0 and zeta potential ranging from <span>(pm)</span> 20 to <span>(pm)</span> 60 mV. The nanoparticles were stable for 30 days irrespective of the storage condition, 4 °C and Room temperature. SEM analysis confirmed spherical type nanoparticles and diameter of the nanoparticles were complementary with DLS (NanoZetaSizer) results. All types of nanoparticles showed higher entrapment of FA, particularly FA-Span-40 NPs showed %EE of 94%, rest of the nanoparticle showed %EE <span>(ge)</span> 85%. The niosomal and liposomal formulations of FA modified the biological behavior of the drug and provided better <i>in vitro</i> performance against <i>S. aureus</i> compared to the standard (FA). Span-40, Tween-20 and cationic liposomes MIC value (0.039–0.078 µg/mL) were effective and comparable with standard, FA (0.04 µg/mL). Furthermore, the effectiveness of antibacterial agents at a microscopic scale was carried out using AFM after contact of all the formulations with <i>Staphylococcus aureus</i> strains. Greater change in the structural and mechanical properties of bacterial cells was observed for FA loaded tween-20 niosomes, and cationic liposomes compared to control and standard FA showing efficacious antibacterial activity. The study demonstrates the designed nano formulations could be a useful strategy to enhance the efficacy of antimicrobials agents.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chitosan/PEO/NiFe2O4 Composite for the Removal of Methyl Orange Dye from Aqueous Solutions: the Effect of NiFe2O4 Nanoparticle Size","authors":"Júlia Audrem Gomes de Oliveira Fadul, Djalma Souza, Marcelo Pagnola, Ricardo Martínez-García","doi":"10.1007/s10876-024-02752-4","DOIUrl":"10.1007/s10876-024-02752-4","url":null,"abstract":"<div><p>This manuscript presents a simple method to obtaining a chitosan/PEO/NiFe<sub>2</sub>O<sub>4</sub> composite with photocatalytic activity under sunlight for the Methyl Orange organic dye degradation. Such composite is made up of two polymers that form a matrix containing nickel ferrite nanoparticles, NiFe<sub>2</sub>O<sub>4</sub>. The polymeric matrix is made up of 70% chitosan and 30% polyethylene oxide (PEO). Due to its chemical structure and microstructure, each polymer provides specific properties to the chitosan/PEO/NiFe<sub>2</sub>O<sub>4</sub> film. The PEO provides mechanical stability to the polymeric substrate and the chitosan provides catalytic properties for the removal of the organic dye. NiFe<sub>2</sub>O<sub>4</sub> nanoparticles are a semiconductor oxide with photocatalytic activity in the range of the visible radiation (bandgap of 1.9 eV); therefore, the dye degradation occurs under sunlight. These NiFe<sub>2</sub>O<sub>4</sub> nanoparticles (NP) are obtained with different NP average size (around 10, 12, and 19 nm). The effect of NiFe<sub>2</sub>O<sub>4</sub> nanoparticles sizes on the properties of the composites, its thermal stability, and on the photocatalytic degradation of the organic dye is analyzed. The photocatalysis test is performed by introducing the chitosan/PEO/NiFe<sub>2</sub>O<sub>4</sub> films into the methyl orange aqueous solution and irradiating them with sunlight for 1 h. The samples are characterized from the structural and morphological point of view, thermal stability, and percentage of photocatalytic degradation of the dye after 1 h of exposure to sunlight. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and ultraviolet-visible spectroscopy (UV-VIS) are used to carry out the study.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elahe Khosravifard, Mohammad Taghi Hamed Mosavian, Morteza Maghrebi
{"title":"Statistical Investigation of Factors Affecting the Growth of Carbon Nanotubes in the Chemical Vapor Deposition (CVD) Processes","authors":"Elahe Khosravifard, Mohammad Taghi Hamed Mosavian, Morteza Maghrebi","doi":"10.1007/s10876-024-02726-6","DOIUrl":"10.1007/s10876-024-02726-6","url":null,"abstract":"<div><p>Carbon nanotubes (CNTs) exhibit exceptional properties, making them invaluable across various industries. Chemical vapor deposition (CVD) is one of the most widely used methods for producing CNTs. This study investigates key factors such as temperature, pressure, and carbon source that influence CNT synthesis. By understanding and controlling these parameters, significant improvements in CNT growth can be achieved. However, CNT growth is influenced by multiple interrelated factors, which complicates the identification of optimal conditions for each individual factor. These variables often interact and are not independent. In this research, we provide a comprehensive review of the critical factors affecting CNT growth to aid researchers in achieving more successful CNT synthesis.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parwin J. Jalil, Renjbar M. Mhamedsharif, Bushra H. Shnawa, Samir M. Hamad, Peyman Aspoukeh, Khanzad W. Wsu, Sida M. Muhammedsharif, Mukhtar H. Ahmed
{"title":"Biosynthesis of ZnO Nanoparticles Using Washingtonia filifera Seed Extract and Assessment of Their Anti-Inflammatory and Antimicrobial Efficacy","authors":"Parwin J. Jalil, Renjbar M. Mhamedsharif, Bushra H. Shnawa, Samir M. Hamad, Peyman Aspoukeh, Khanzad W. Wsu, Sida M. Muhammedsharif, Mukhtar H. Ahmed","doi":"10.1007/s10876-024-02761-3","DOIUrl":"10.1007/s10876-024-02761-3","url":null,"abstract":"<div><p>The green synthesis of nanoparticles represents an eco-friendly and sustainable alternative to conventional chemical and physical synthesis methods. This approach minimizes the use of hazardous chemicals and leverages biological resources, aligning with the principles of green chemistry. This study aimed to characterise the green synthesised ZnONPs and evaluate their antimicrobial and anti-inflammatory activities. ZnONPs were synthesised using <i>Washingtonia filifera seed</i> extract and characterised using Scanning Electron Microscopy (SEM), UV–Vis spectroscopy, Fourier Transform Infrared (FT-IR) spectroscopy, energy-dispersive spectroscopy (EDX), and X-ray diffraction (XRD). Their antimicrobial activity against bacteria and fungi, as well as their anti-inflammatory potency, were assessed. SEM data revealed that the ZnONPs, fabricated with palm seed extract metabolites, were spherical with an average size of 50 nm. FT-IR analysis identified varied absorption peaks related to the functional groups of the plant extract and nanoparticles. The antimicrobial activity was dose-dependent, with <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> showing inhibition zones of 8.5 ± 0.7 mm and 11.8 ± 0.3 mm, respectively, at 500 µg/mL. <i>Pseudomonas aeruginosa</i> exhibited a notable inhibition zone of 20.4 ± 0.7 mm. The ZnONPs also inhibited fungal mycelium growth. The in vitro anti-inflammatory activity of ZnONPs showed a concentration-dependent increase, with an 89.15% inhibition of RBC haemolysis at 110 µg/mL. The green synthesised ZnONPs demonstrated significant antimicrobial activity against clinical pathogens and potent anti-inflammatory effects, suggesting that this eco-friendly method could be a promising strategy for developing versatile biomedical products.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Velarasan, P. Puviarasu, P. Sujita, Sethumathavan Vaauthorel
{"title":"Rational Design of Novel Tantalum Based (CuTaS3/AgTaS3) Heterostructures for Photocatalytic and Electrocatalytic Hydrogen Production","authors":"V. Velarasan, P. Puviarasu, P. Sujita, Sethumathavan Vaauthorel","doi":"10.1007/s10876-024-02744-4","DOIUrl":"10.1007/s10876-024-02744-4","url":null,"abstract":"<div><p>The present investigation successfully synthesized a novel tantalum-based CuTaS<sub>3</sub>/AgTaS<sub>3</sub> heterostructure using D-penicillamine as a sulfur source and investigated its hydrogen evolution capability using both photocatalytic and electrocatalytic methods. The structural and morphological features were examined using XRD, Raman, FT-IR, TEM and SEM with EDS analysis, respectively. The UV-DRS results ascertain the visible-light response and bandgap of the synthesized materials. Combining AgTaS<sub>3</sub> with CuTaS<sub>3</sub> reduced the recombination rate, as revealed by the photocurrent measurements of the materials. The photocatalytic hydrogen production for the as-synthesized materials was investigated by consuming Na<sub>2</sub>S + Na<sub>2</sub>SO<sub>3</sub> as a sacrificial reagent. The CuTaS<sub>3</sub> with 5% of the best AgTaS<sub>3</sub> loading gives off the most H<sub>2</sub> evolution rate, 1430 µmol/g, after 5 h of being exposed to visible light. Furthermore, the electrocatalytic measurements were performed to assess the CuTaS<sub>3</sub>/AgTaS<sub>3</sub> heterostructure for water-splitting hydrogen evolution reactions (HER). The results displayed that the enhanced HER reactivity with lower overpotentials and Tafel slope when heterostructure was formed. The higher double-layer capacitance (C<sub>dl</sub>) value shows how many more active sites were formed after AgTaS<sub>3</sub> was combined with CuTaS<sub>3</sub>. These results confirmed that the CuTaS<sub>3</sub>/AgTaS<sub>3</sub> heterostructure generated H<sub>2</sub> effectively in both electrocatalytic and photocatalytic processes. The present work may bring innovative perceptions for the advancement of tantalum-based sulfide materials for green hydrogen production.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, Characterization, and Functional Analysis of Mixed Manganese/Cerium Oxide/Hydroxyapatite Nanocomposites for Antibacterial Applications","authors":"Sakuntala Siri-Udom, Orrasa Prasitnok, Khongvit Prasitnok, Pongtanawat Khemthong, Chaiyasit Phawa, Wuttichai Roschat, Songkot Utara, Narid Prachumrak, Jiyapa Sripirom, Piaw Phatai","doi":"10.1007/s10876-024-02750-6","DOIUrl":"10.1007/s10876-024-02750-6","url":null,"abstract":"<div><p>Mixed manganese/cerium oxide/hydroxyapatite composites are emerging as innovative materials with significant biomedical potential due to their antibacterial properties and biocompatibility. In this study, we synthesized mixed Mn/Ce oxide/HA composites using an ultrasonic-assisted sol-gel method, exploring their structural and functional characteristics through comprehensive analyses. Advanced characterization techniques, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), X-ray absorption spectroscopy (XAS), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and nitrogen adsorption-desorption isotherms, revealed a composite with enhanced structural stability and porosity, optimized for antibacterial applications. XRD confirmed the integration of a fluorite-structured CeO<sub>2</sub> phase with hexagonal hydroxyapatite, while FT-IR and XANES analyses verified the presence of functional phosphate groups and mixed oxidation states (Ce<sup>3+</sup>/Ce<sup>4+</sup>, Mn<sup>2+</sup>/Mn<sup>3+</sup>/Mn<sup>4+</sup>), essential for antibacterial efficacy. SEM imaging displayed a unique flake-like morphology conducive to clustering, and EDS confirmed elemental composition. Notably, nitrogen sorption isotherms revealed a marked increase in surface area from 2 m²/g in pure HA to 11–16 m²/g in Mn/Ce oxide/HA, which may enhance bacterial interaction. Antibacterial assays demonstrated potent activity against <i>Bacillus cereus</i> (<i>B. cereus</i>), <i>Staphylococcus aureus (S. aureus)</i>, <i>Staphylococcus epidermidis (S. epidermidis)</i>, <i>Escherichia coli (E. coli)</i>, and <i>Salmonella typhi (S. typhi)</i>, linked to reactive oxygen species production and bacterial membrane disruption. This study highlights the robust structural and antibacterial features of Mn/Ce oxide/HA composites, advancing their suitability for biomedical applications, particularly in infection-resistant materials and bone grafts.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetics and Brain Tumor Delivery Studies of Thymoquinone-Encapsulated Eudragit L100-Coated Solid-Lipid Nanoparticles","authors":"Jeganpandi Senthamarai Pandi, Parasuraman Pavadai, Lakshmi M. Sundar, Murugesan Sankaranarayanan, Theivendren Panneerselvam, Sureshbabu Ram Kumar Pandian, Selvaraj Kunjiappan","doi":"10.1007/s10876-024-02751-5","DOIUrl":"10.1007/s10876-024-02751-5","url":null,"abstract":"<div><p>Brain tumor is one of the deadliest types of cancer in the world. The basic necessity of brain tumor-targeted therapy is to reach and accumulate the required quantity in the tumor microenvironment while maintaining therapeutic efficacy. In this regard, the current study sought to create thymoquinone-encapsulated Eudragit L100-coated solid lipid nanoparticles (TQ-encapsulated E-SLNs) for the transport of loaded thymoquinone (TQ) to the brain. TQ-encapsulated E-SLNs were formulated using the oil-in-water microemulsion process, and their physicochemical properties were investigated. TQ encapsulation, loading capacity, and release behavior of E-SLNs were also investigated. In vivo biodistribution studies were conducted to assess TQ delivery and accumulation in several organs of female Wistar rats. The TQ-encapsulated E-SLNs were mostly spherical with a crystalline structure and extremely stable in the physiological buffer system. The highest content of TQ was released in pH 5.5 (78.215 ± 0.749%) at 22 h. The pharmacokinetics and biodistribution investigations revealed that released TQ from TQ-encapsulated E-SLNs after 48 h of administration accumulated 16.5 ± 1.5% in brain, 21.167 ± 1.041% in kidneys, 12.125 ± 0.781% in heart, 16.375 ± 1.317% in liver, 13.5 ± 1.8% in lungs, and 17.15 ± 1.5%. Later, molecular modeling studies revealed that TQ had a greater binding energy of -7.8 kcal/mol to EGFR. Thymoquinone binding energy was very close to the reference drug Temozolomide. Molecular dynamics simulation studies showed that the TQ-EGFR docked complex was extremely stable up to 100 ns. The findings showed that the fabricated TQ-encapsulated E-SLNs remained unchanging in circulation for up to five days. Therefore, E-SLNs fabrications show promise as a method for targeting brain malignancies across the BBB.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yurii A. Kurapov, Stanislav Ye. Lytvyn, Gennadii G. Didikin, Olena I. Oranska, Sergei M. Romanenko
{"title":"Dynamics of Sorption Processes at Physical Synthesis of Iron Nanoparticles","authors":"Yurii A. Kurapov, Stanislav Ye. Lytvyn, Gennadii G. Didikin, Olena I. Oranska, Sergei M. Romanenko","doi":"10.1007/s10876-024-02743-5","DOIUrl":"10.1007/s10876-024-02743-5","url":null,"abstract":"<div><p>Scanning and transmission electron microscopy, powder X-ray diffraction and thermogravimetric analyses were used to study the dynamics of the sorption processes of ligand-free iron nanoparticles produced by highly efficient physical synthesis, namely, the molecular beam method. The structure, chemical and phase composition of Fe-NaCl condensates with different iron contents, crystallite dimensions (nanoparticles) and nanoparticle surface areas depending on the condensation temperature, which characterize the sorption capacity, primarily for moisture and oxygen, were studied. Finally, the gravimetric analysis method was used to investigate the kinetics of the relative change in the weight of porous Fe–NaCl condensates with different iron contents, depending on the condensation temperature. With increasing synthesis temperature, the nanoparticle size increases, and the specific surface area decreases. Therefore, by changing the size of the nanoparticles at the same volume, we can regulate the ratio of the nanoparticle surface to the nanoparticle volume, i.e., change the properties of the reaction surface and, in this way, the contribution of the excess surface energy to the total free energy of the system. The mass fraction of physically adsorbed and bound oxygen (moisture) correlates with the size (area, surface) of the nanoparticles.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>Sorption of oxygen and water by EB PVD ligand-free Fe@Fe<sub>3</sub>O<sub>4</sub> nanoparticle in open matrix nanopore</p></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}