Journal of Cluster Science最新文献

{"title":"Effect of Zn Substitution on Properties of Ni0.6−xZnxMn0.4Fe2O4(x = 0.0,0.2,0.4,0.6) and to Study its Antibacterial Activity as a Potential Antibacterial Agent","authors":"Sanjali Navelkar,&nbsp;Komal Salkar,&nbsp;Lakshangy Charya,&nbsp;V. M. S. Verenkar","doi":"10.1007/s10876-024-02745-3","DOIUrl":"10.1007/s10876-024-02745-3","url":null,"abstract":"<div><p>Ni_0.6−xZn_xMn_0.4Fe₂O₄ (x = 0.0,0.2,0.4,0.6) were prepared by the combustion method using hexamine as the fuel. Zinc replacement in place of Ni and its effect on various structural, electric, magnetic, and dielectric properties was studied using several instrumental techniques. X-ray diffraction revealed a monophasic cubic spinel structure for the samples. Scherrer’s formula determined that the crystallite size (D) was in the nano range from 8 to 15 nm. The lattice constant values showed an increment with zinc content while porosity was seen to drop. The scanning electron microscopy images showcased agglomerated particles due to magnetic interaction between them and were found to have spherical morphology. TEM provided the average particle size obtained from the histogram, while the SAED pattern revealed the semicrystalline nature of the samples. Infrared spectra showed two metal-oxygen peaks peculiar to spinel ferrite in the range of ~ 400–600 cm^− 1. Confirmation of the spinel phase was made using room temperature Raman analysis, and the change in Raman peaks was observed with an increase in zinc content. XPS studies revealed Ni^+ 2, Mn^+ 2, Zn^+ 2, and Fe^+ 3 to be in their respective valence states. A resistivity study was conducted from RT- 500 °C, which showed a decrease in resistivity with an increase in temperature, a typical trend of semiconduction. Dielectric studies performed at RT showed the highest dielectric constant with the minimum dielectric loss for sample x = 0.2, while variable temperatures studied at different frequencies showed x = 0.6 with the highest dielectric constant. Saturation magnetization values increased up to x = 0.4, which Neel’s two sublattices model explained, and a further decrease in magnetization was explained by the Yafet- Kittle model. AC susceptibility revealed Curie temperature up to the point where the sample behaved as ferrimagnetic material. The main aim and objective were to explore the suitability of synthesized materials for their applications and to study zinc’s influence on various properties and antibacterial activity. The antibacterial activity of the samples was investigated as a potential candidate against highly resistant and infectious <i>Staphylococcus aureus</i>, and sample x = 0.2 showed the best results.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Iron and Cobalt Oxide Nanocatalysts with Various Molar Ratios and Their Application for Antibiotic Removal from Aqueous Solutions","authors":"Sepideh Ghasemi,&nbsp;Farideh Nabizadeh Chianeh","doi":"10.1007/s10876-024-02732-8","DOIUrl":"10.1007/s10876-024-02732-8","url":null,"abstract":"<div><p>With the growing concern over the environmental and health risks posed by antibiotic contamination in water systems, this study evaluates the potential of iron and cobalt oxide nanocatalysts with varying molar ratios, synthesized using the co-precipitation method, for the efficient removal of antibiotics from aqueous solutions. The optimal nanocatalysts were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM), revealing high surface area and well-defined crystalline structures, enhancing catalytic activity. Kinetic analysis showed that Co_0.5Fe_0.5Fe₂O₄ exhibited the best performance, with a Michaelis–Menten constant (<i>K</i>_<i>m</i>) of 0.0366 mM and maximum reaction velocity (<i>V</i>_<i>max</i>) of 1.10 × 10⁻⁴ µM.min⁻¹. The reaction rate constants, <i>k₁</i> = 6.12 × 10³ M⁻¹ S⁻¹ and <i>k</i>_<i>3</i> = 3.64 × 10² M⁻¹ S⁻¹) and turnover number (kcat = 5.213 × 10⁻¹ S⁻¹) confirmed its superior catalytic properties. Antibiotic removal was further evaluated through batch adsorption experiments, with adsorption kinetics and isotherms studied to determine optimal conditions for antibiotic removal. The Co_0.5Fe_0.5Fe₂O₄ nanocatalyst exhibited superior peroxidase-like activity compared to the other nanocatalysts when tested with the common chromogenic substrate 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) diammonium salt. Based on this enzymatic activity, a colorimetric sensing platform was designed for H₂O₂ detection. Additionally, the Co_0.5Fe_0.5Fe₂O₄ nanocatalyst exhibited excellent adsorption capacity for various antibiotics, including ciprofloxacin, azithromycin, levofloxacin, moxifloxacin, amoxicillin, and metronidazole, with 100% removal efficiency under optimal conditions. This study highlights the potential of enzyme-mimicking nanostructures as efficient adsorbents for the removal of antibiotics from aqueous solutions, addressing significant environmental challenges posed by antibiotic contamination.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Therapeutic Potential of Bioengineered Ag-doped HAp Nanocomposites Against Proteus mirabilis and MCF-7 Breast Cancer Cell Line","authors":"Suvetha Selvam,&nbsp;Alycia Devasagayam,&nbsp;Arun Kumar Mani","doi":"10.1007/s10876-024-02741-7","DOIUrl":"10.1007/s10876-024-02741-7","url":null,"abstract":"<div><p>Globally, the major threat is the rise of antimicrobial-resistant diseases and the increasing incidence of cancer, both of which are leading causes of death due to a lack of effective therapies. Nanocomposites (NCs) have recently emerged as an alternative therapeutic agent for the development of novel medications. The current study demonstrates the fast production of Ag-HAp NCs with an aqueous bark extract of <i>Acacia nilotica</i> and evaluates their antiquorum sensing and anticancer activities. UV-vis spectroscopy, Fourier-transformed infrared spectroscopy, X-ray diffraction analysis, zeta sizer, field emission scanning electron microscopy, and high-resolution transmission electron microscopy were used to evaluate the physicochemical and morphological observations of Ag-HAp NCs. The biofabricated NCs demonstrated the ability to inhibit the violacein production in bioreporter strain <i>Chromobacterium violaceum</i> and mitigate the virulent factors in multidrug-resistant <i>Proteus mirabilis.</i> Sub-MIC concentrations of 2% Ag-HAp NCs (80 µg/mL) efficiently decreased the quorum sensing regulated virulence factors such as biofilm formation, exopolysaccharide synthesis, urease, hemolysin, and cell motility, that contribute to antibiotic resistance. Furthermore, an <i>invitro</i> cytotoxicity study of 2% Ag-HAp NCs revealed exceptional anticancer potential against the MCF-7 cell line using MTT assay. The microscopic studies (ROS and DAPI assay) demonstrated that the synthesized NCs elicit cellular cytotoxicity at a low dosage (IC₅₀ − 23.2 µg/mL). All experiments were carried out in triplicate (<i>n</i> = 3) to establish the statistical significance. Thus, phyto-mediated synthesized 2% Ag-HAp NCs are environmentally acceptable and non-toxic nanomaterials suitable for biomedical applications.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Cyclodextrin/PVP-Stabilized Nanocrystal Gel for Dual Release of Rutin and Thymoquinone for Wound Healing","authors":"Tahani M. Almeleebia,&nbsp;Nandini Goyal,&nbsp;Md Habban Akhter,&nbsp;Amnah Alalmaie,&nbsp;Alhanouf I. Al-Harbi,&nbsp;Habibullah Khalilullah,&nbsp;Md Sajid Ali,&nbsp;Mohammad Intakhab Alam,&nbsp;Sarfaraz Ahmad,&nbsp;Nawazish Alam,&nbsp;Gyas Khan,&nbsp;Mariusz Jaremko,&nbsp;Abdul-Hamid Emwas","doi":"10.1007/s10876-024-02735-5","DOIUrl":"10.1007/s10876-024-02735-5","url":null,"abstract":"<div><p>The timely repair of injured skin is of outmost importance as the impaired wound healing may provoke infections, formation of scarring tissues, and delayed wound closure. ThQ + Rut-loaded NC gel was produced using the ultrasonication nanoprecipitation technique and investigated for dermal wound healing. Formulations were characterized for particle size distribution, and ζ − potential, % drug entrapment, and % loading. The optimum NC gel was characterized for viscosity, spreadability, and gel texture. The optimized nanocrystal gel was produced and tested on fibroblast cell line and tested in vivo for healing assessment. The optimum particle size of obtained NC was 192 ± 2 nm, PDI of 0.201, with a ζ-potential of -9.9 ± 1.9 mV. Further, Rut and ThQ entrapment and loading from ThQ + Rut-loaded NC gel, were measured to 89 ± 0.9%, 85.7 ± 1.5%; 21 ± 2%, and 17.5 ± 2%. The NC gel showed viscosity of 1488 ± 0.12 mPa*s at shear rate of 40 (1/s). The hydrogel texture analysis revealed firmness, consistency and cohesiveness of 43.88 g, 208.19 g.sec, and − 15.88 g, respectively. The cell viability studies revealed that Rutin and ThQ in NC gel significantly enhanced proliferation of fibroblast cell vis-a-vis to drug suspensions (<i>p</i> &lt; 0.01). The histopathology demonstrated that ThQ + Rut-loaded NC gel improved collagen formation and tissue remodelling towards wound healing compared with other treatment groups. Thus, we may conclude that Rut and ThQ from nanocrystal gel is safe and will improve the dermal wound healing process.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction and Characterization of Cellulose Nanocrystals from Brown Seaweed Dictyota Bartayresiana, J.V. Lamouroux","authors":"Sobiya Murugesan,&nbsp;S. R. Radhika Rajasree,&nbsp;Roopa Rajan","doi":"10.1007/s10876-024-02721-x","DOIUrl":"10.1007/s10876-024-02721-x","url":null,"abstract":"<div><p>Cellulose nanocrystals (CNC) are a sustainable, biodegradable, and versatile material with numerous advantageous and potential applications in diverse industries. For the first time, CNC was derived from the biomass of <i>Dictyota bartayresiana</i>, a brown seaweed from Dictyotaceae, having commercial value and therapeutic benefits. This process involved comprehensive extraction techniques, including acid hydrolysis and mechanical dispersion, to transform the seaweed into nanocellulosic material. The structural analysis, conducted via Transmission Electron Microscopy (TEM), affirmed that the resulting CNC displayed an average width of approximately 26 nm and a length extending to 520 nm long. X-ray Diffraction (XRD) analysis indicated that these extracted CNC constituted around 62% of the crystallinity index. Fourier Transform Infrared (FTIR) spectral analysis confirmed the successive removal of non-cellulosic components through chemical treatments. Elemental analysis (CHNS) validated the presence of sulfate groups, accounting for 0.59%. Thermogravimetric Analysis (TGA) results unveiled the superior thermal stability of the extracted CNC.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Studies of Copper Species in Supported CuO/CeO2 Catalyst by X-ray Absorption Spectroscopy Coupled with Pair Distribution Function Analysis","authors":"Vera P. Pakharukova,&nbsp;Vladimir V. Kriventsov,&nbsp;Arcady V. Ishchenko,&nbsp;Dmitry I. Potemkin,&nbsp;Pavel V. Snytnikov","doi":"10.1007/s10876-024-02727-5","DOIUrl":"10.1007/s10876-024-02727-5","url":null,"abstract":"<div><p>Ceria-supported copper catalysts exhibit high catalytic performance in the preferential oxidation of CO in excess H₂ (CO PROX). Highly dispersed copper oxide species have been experimentally identified as active centers. However, structural diagnostics of highly dispersed CuO_x species and CuO_x/CeO₂ interface areas remains a challenge. Here, we report a comprehensive structural study of a supported CuO/CeO₂ catalyst (5 wt% Cu) showing good activity in the CO PROX process. X-ray absorption spectroscopy (XAS) techniques and X-ray atomic pair distribution function (PDF) analysis were used as efficient methods for probing the atomic resolution structure. It was established that the catalyst contains Cu²⁺ species, mainly in the form of ultra-dispersed CuO-like particles and copper oxide clusters. Analysis of the local atomic arrangement revealed an interaction between copper ions and ceria surface. Oxygen-terminated {100} ceria facets can accommodate Cu²⁺ ions in square planar coordination. Moreover, some Cu ions are inserted into the CeO₂ crystal structure, forming a substitutional solid solution.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Plants Extract for the Bio-Assisted Synthesis of Ag/AgCl Nanoparticles with Antibacterial Activity","authors":"Jorge Luis Torres-López,&nbsp;Stephania Lázaro-Mass,&nbsp;Susana De la Rosa-García,&nbsp;Mayra A. Alvarez-Lemus,&nbsp;Abraham Gómez-Rivera,&nbsp;Rosendo López-González,&nbsp;Carlos Ernesto Lobato-García,&nbsp;Getsemani Morales-Mendoza,&nbsp;Sergio Gómez-Cornelio","doi":"10.1007/s10876-024-02722-w","DOIUrl":"10.1007/s10876-024-02722-w","url":null,"abstract":"<div><p>The increasing antibiotic resistance necessitates sustainable methods for synthesizing antibacterial nanoparticles. This study focuses on the bio-assisted synthesis of silver/silver chloride nanoparticles (Ag/AgCl-NPs) using aqueous extracts of <i>Acalypha arvensis</i>, <i>Hampea rovirosae</i>, and <i>Inga jinicuil</i>. Polyphenols and flavonoids were quantified, and functional groups were analyzed via Fourier-transform infrared to assess their influence on the properties of Ag/AgCl-NPs. The effects of thermal treatment at 60 and 500 °C on the NPs’ size, morphology, and antibacterial efficacy were assessed. UV–Vis spectroscopy indicated absorption peaks between 430 and 449 nm, while X-ray diffraction analysis confirmed the presence of metallic Ag and a cubic AgCl structure, with crystallite sizes ranging from 11–51 and 28–60 nm, respectively. Dynamic light scattering showed hydrodynamic sizes of up to 127.2 ± 0.9 nm at 60 °C and up to 348.9 ± 10.7 nm at 500 °C. Field emission scanning electron microscopy micrographs exhibited a quasi-spherical morphology with significant agglomeration; showing particle sizes between 55 ± 11 and 81 ± 28 nm at 60 °C, and up to 135 ± 65 nm at 500 °C. X-ray photoelectron spectroscopy confirmed the metallic silver (Ag⁰), organic molecules, and absorbed chlorides on the NP surface. Pearson correlation analysis indicated a strong positive correlation between polyphenol content and NPs yield (r = 0.922), while it indicated a strong negative correlation with flavonoid content (r = −0.996). Additionally, a negative correlation was found between hydrodynamic size and antibacterial activity against <i>Staphylococcus aureus</i> (r = −0.854). The Ag/AgCl-NPs, after drying at 60 and 500 °C, were tested against <i>Escherichia coli</i> and <i>S. aureus</i> with minimum bactericidal concentrations below 19 µg/mL against <i>E. coli</i>. Minimum inhibitory concentration (MIC) for Ag/AgCl-NPs synthesized with <i>A. arvensis</i> and <i>H. rovirosae</i> extracts were above 312 µg/mL for <i>S. aureus</i>, while those synthesized with <i>I. jinicuil</i> showed MIC as low as 156 µg/mL. These results highlight the potential of medicinal plant extracts in the synthesis of Ag/AgCl with enhanced antibacterial properties.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into Antimicrobial, Antioxidant, Anticancer, and Antidiabetic Activities of Trimetallic Se/ZnO/CuO Nanoalloys Fabricated by Aqueous Extract of Nitraria retusa","authors":"Mohamed A. Amin,&nbsp;Noura A. Algamdi,&nbsp;Moayad S. Waznah,&nbsp;Duaa A. Bukhari,&nbsp;Sultan M. Alsharif,&nbsp;Fahad Alkhayri,&nbsp;Mahmoud Abdel-Nasser,&nbsp;Amr Fouda","doi":"10.1007/s10876-024-02742-6","DOIUrl":"10.1007/s10876-024-02742-6","url":null,"abstract":"<div><p>The unique features of trimetallic nanoalloys to be used in biomedical applications have taken more attention instead those of mono and bimetallic nanoparticles. Leaf aqueous extract of <i>Nitraria retusa</i> was utilized for the first time to synthesize trimetallic Se/ZnO/CuO (TSZC) nanoalloys. Data displayed the formation of crystallographic and spherical TSZC with an average size of 47.69 ± 1.95 nm by the action of active molecules in <i>N. retusa</i> extract. EDX analysis reveals the existing Se, Zn, and Cu peaks at specific bending energies with weight percentages of 17.03, 9.44, and 8.36% respectively. TSZC showed promising antimicrobial activity against <i>Staphylococcus aureus</i>,<i> Escherichia coli</i>,<i> Candida albicans</i>, and <i>Penicillium glabrum</i>, superior the activity of positive control. The clear zones ranging from 12.3 ± 0.6 to 32.7 ± 0.5 mm were attained due to TSZC treatment with MIC values of 12.5 µg mL^–1 for <i>E. coli</i>,<i> C. albicans</i>, and <i>P. glabrum</i>, and 50 µg mL^–1 for <i>S. aureus.</i> The maximum DPPH scavenging activity (90.1 ± 0.2%) was attained at 1000 µg mL^–1 TSZC compared to ascorbic acid (98.3 ± 0.2%). The IC₅₀ of TSZC nanoalloys against normal cell line (WI38) was 294.9 ± 4.4 µg mL^–1 compared to IC₅₀ against cancer cells (Caco-2 = 83.01 ± 1.1; Mcf7 = 91.7 ± 1.2 µg mL^–1) Which indicates that the TSZC are targeted cancer cells at low concentrations. Finally, the inhibition of α-amylase and α-glucosidase by TSZC with IC₅₀ values of 23.2 ± 3.8 and 32.1 ± 2.6 µg mL^–1 respectively compared to acarbose as a positive control (IC₅₀ = 10.9 ± 1.5 and 15.9 ± 1.8 µg mL^–1 for α-amylase and α-glucosidase respectively) indicates the superior antidiabetic activity in-vitro.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIE-Fluorescent TPENC12 Nanoliposome: Construction and Characterization of Optical Properties","authors":"Hongye Liao,&nbsp;Xun Yang,&nbsp;Xinyu Shi,&nbsp;Jianv Wang,&nbsp;Tong Xia,&nbsp;Simei Yang,&nbsp;Qingqing He,&nbsp;Xia Xiong,&nbsp;Li Liu,&nbsp;Changzhen Sun","doi":"10.1007/s10876-024-02731-9","DOIUrl":"10.1007/s10876-024-02731-9","url":null,"abstract":"<div><p>The advancement of optical imaging technology has greatly facilitated the research on fluorescent probes with tumor imaging capabilities. Tetraphenylethlene (TPE) is a well-known molecule with aggregation-induced emission (AIE) properties. Accordingly, its derivatives have been widely used for fluorescence imaging of tumors. In the present study, we designed and synthesized five AIE molecules that contained TPE and had varying alkyl chain lengths. The fluorescent molecules were found to adhere to the two rules of spectroscopy in both favorable and unfavorable solvents. Furthermore, all molecules were able to form aggregates in the DCM/n-hexane mixture, demonstrating the AIE effect. Among them, TPENC12 possessed the most appropriate alkyl chain length. Following the five molecules successful integration into nanoliposomes. The nanoliposomes were screened, to obtain the TPENC12 nanoliposome that exhibited the highest fluorescence intensity. TPENC12 nanoliposome were capable of being taken up by melanoma cells, thus, effectively enabling tumor imaging. Moreover, they demonstrated a significant anti-tumor effect against melanoma at low concentrations, while exhibiting minimal toxicity towards normal cells. The present study, thus, offers valuable insights into the molecular structure design of AIE-based TPE derivatives for fluorescent imaging, thereby highlighting their potential for use in tumor imaging, as well as in the treatment of melanoma.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Chitosan-Modified Diclofenac Acid Prodrug Nanoparticles and Evaluation of Their Anti-Inflammatory Effects in a Preclinical Model","authors":"Shahida Muhammad Habib,&nbsp;Huma Ikram,&nbsp;Shafi Ullah,&nbsp;Abdul Jabbar,&nbsp;Saira Yasmeen,&nbsp;Muhammad Raza Shah","doi":"10.1007/s10876-024-02734-6","DOIUrl":"10.1007/s10876-024-02734-6","url":null,"abstract":"<div><p>Diclofenac acid (DA) is widely employed in various clinical settings for pain management. However, prolonged use of DA can induce various adverse effects on the gut, including ulcers and intestinal bleeding. There is also a possible link between the extended use of DA and its increased susceptibility to cardiovascular diseases. Prodrug-based nanoparticles (NPs) have emerged as a promising approach for drug delivery and overcome side effects. In this investigation, a diclofenac acid-based prodrug (DA-P) was synthesized and subsequently used for developing NPs (DA-P-NPs). The developed NPs were further modified with chitosan (DA-P-NPs-CHI) to achieve stability and sustained release of the drug. The DA-P was chemically synthesized and confirmed with EI-mass spectrometry, ¹H-NMR, and ¹³C-NMR spectroscopic techniques. The characterization of DA-P-NPs and DA-P-NPs-CHI involved several techniques, such as atomic force microscopy (AFM and SEM), DLS, FTIR, TGA, and DSC. DA-P demonstrated a reduced critical micelle concentration (CMC) of 0.07 mg/mL and effectively encapsulated more drug within the NPs. DA-P-NPs and DA-P-NPs-CHI exhibited average particle sizes of 130.7 ± 0.6 and 230.2 ± 5.3 nm, and surface charges of -36.2 ± 2.0 and 41.2 ± 0.9 mV, respectively. DA-P-NPs-CHI exhibited a drug-release rate remarkably greater at acidic pH. A paw-edema model was induced <i>via</i> formalin exposure to evaluate the anti-inflammatory effect of DA-P-NPs-CHI. Assessment of anti-inflammatory activity demonstrated that the use of DA-P-NPs-CHI resulted in a substantial reduction in edema compared to diclofenac-treated rats. These findings demonstrate that the proposed DA-P-NPs possess the promising attributes that make them a possible alternative therapy for pain and inflammation.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}