卫生研究最新文献

{"title":"[Relationship between 25(OH)D levels during pregnancy and maternal blood glucose, lipids with maternal and neonatal immunity indicators].","authors":"Zhaoyang Nian, Yanhui Li, Yuting Lin, Limei Mao","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.008","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.03.008","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the vitamin D nutritional status of women in Guangzhou during pregnancy, and explore the relationship between 25-hydroxyvitamin D(25(OH)D) levels during pregnancy and maternal blood glucose, blood lipids, and immune indicators of both mothers and newborns.</p><p><strong>Methods: </strong>A total of 533 pregnant women who were scheduled to give birth in the Maternal and Child Health Hospitals of Yuexiu and Baiyun Districts of Guangzhou from September 2010 to February 2011 were selected as the study subjects, and baseline information on maternal age, pre-pregnancy height and weight was collected through questionnaires, and dietary habits and dietary intake were collected by using a 3-day, 24-hour dietary review method. Fasting venous blood was collected from pregnant women at 37 to 42 weeks of pregnancy, and umbilical cord blood was collected from newborns at the time of delivery, to follow up the delivery of pregnant women and the birth of newborns, such as gestational age and weight, and other basic information. Serum 25(OH)D, fasting blood glucose, blood lipids and immunocytokine levels were measured in pregnant women and immunoglobulin and cytokine levels were measured in umbilical cord blood of newborns. Multiple linear regression was used to analyze the relationship between maternal 25(OH)D levels and maternal blood glucose, lipids, with maternal and neonatal immune indicators.</p><p><strong>Results: </strong>The mean age of the pregnant women was(27.3±4.2) years, the mean gestational age at birth of the newborns was(39±1) weeks, and the mean birth weight was(3229.7±375.3) g. The M(P25, P75) of the serum 25(OH)D levels of the pregnant women was 47.05(35.10, 59.60) nmol/L. Serum 25(OH)D levels of the pregnant women showed a negative correlation with the pregnant women's fasting blood glucose and blood lipids(blood glucose(GLU): r_s=-0.177; total cholesterol(TC): r_s=-0.152; triglycerides(TG): r_s=-0.176; low-density lipoprotein cholesterol(LDL-C): r_s=-0.132; and high-density lipoprotein cholesterol(HDL-C): r_s=-0.161)(P<0.05). After controlling for potential confounding variables such as maternal age, gestational week of delivery, and pre-pregnancy BMI, multiple linear regression analyses showed that maternal serum 25(OH)D levels were still negatively correlated with maternal fasting glucose and lipids(GLU: β=-0.008; TC: β=-0.015; TG: β=-0.011; LDL-C: β=-0.008; HDL-C: β=-0.004)(P<0.05). Maternal serum 25(OH)D levels were negatively correlated with maternal interferon-γ(IFN-γ)(r_s=-0.173, P<0.05) and positively correlated with maternal interleukin-6(IL-6)(r_s=0.225, P<0.05) and neonatal IL-6 levels(r_s=0.140, P<0.05). After controlling for potential confounding variables such as maternal age, gestational week of delivery, and pre-pregnancy BMI, multivariate linear regression analysis showed that maternal serum 25(OH)D levels were still negatively associated with maternal IFN-γ(β","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"405-418"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Determination of seven phenolic acids in whole wheat flour by high-performance liquid chromatography].","authors":"Jun Wang, Beilei Cai, Weisheng Xu, Chao Gao, Guodong Wang, Xuesong Zhang, Zhu Wang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.022","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.03.022","url":null,"abstract":"<p><strong>Objective: </strong>A high-performance liquid chromatography(HPLC) method was established for the simultaneous determination of 7 phenolic acids(ferulic acid, p-coumaric acid, vanillic acid, butyric acid, p-hydroxybenzoic acid, salicylic acid, sinapic acid) in whole wheat flour, to understand further the phenolic acid substances contained in whole wheat flour and the content level.</p><p><strong>Methods: </strong>Add 10 mL of 4% NaOH solution, 10 mL of methanol solution, and 0.4 g of sodium sulfite(antioxidant) to the whole wheat flour sample, and extract it at high temperature under ultrasonic conditions. Centrifuge the supernatant, adjust the pH 5, and then dilute it to the final volume. Use Waters Atlantis T3(4.6 mm×250 mm, 5 μm) as the chromatographic column, and determine the phenolic compounds by high-performance liquid chromatography under switching wavelength conditions, with external standard calibration.</p><p><strong>Results: </strong>The linear correlation coefficients(R~2) of the standard curve were all greater than 0.999. The limits of detection(LODs) of the method was 0.01-0.09 mg/100 g, and the limits of quantification(LOQs) of the method was 0.03-0.29 mg/100 g. The three-level recovery rate was 87.6%-115.7%. The precision RSDs was 2.1%-6.3%(n=6). The phenolic acid assay of 22 commercial whole wheat flours showed that ferulic acid was the highest among the seven phenolic acids(40.1 mg/100 g), followed by sinapic acid(5.8 mg/100 g).</p><p><strong>Conclusion: </strong>The method has good sensitivity, precision and reproducibility, and is suitable for the determination of phenolic acids in whole wheat flour.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"500-505"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Determination of 27 perfluoroalkyl substances in pork by ultra-high performance liquid chromatography-tandem mass spectrometry].","authors":"Yushen Jin, Yang Xing, Kaixin Xu, Yumin Niu, Bing Shao","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.024","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.03.024","url":null,"abstract":"<p><strong>Objective: </strong>A method based on QuEChERS and ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was established for the detection of 27 perfluoroalkyl substances(PFASs) in pork.</p><p><strong>Methods: </strong>Pork samples were extracted with acetonitrile-water(8∶2, V/V), and the supernatant was purified with 100 mg primary secondary amine(PSA) and 40 mg octadecylsilyl(C18). Separation was performed using an Ascentis~(TM) Express F5(2.1 mm × 150 mm, 2 μm) chromatographic column, and detection was carried out using UPLC-MS/MS with internal standard quantification.</p><p><strong>Results: </strong>The 27 PFASs exhibited good linearity in the range of 0.01-50 μg/L, with limit of detection(LOD) ranging from 0.004 to 0.044 μg/L and limit of quantification(LOQ) ranging from 0.015 to 0.145 μg/L. The intra-day and inter-day precision were determined at a spiking level of 2LOQ, with a recovery rate of 72.4%-109.7% and 78.6%-110.7%, an intra-day relative standard deviation(RSD) of 1.2%-9.6%(n=6), and an inter-day RSD of 1.0%-13.8%(n=5), respectively. Using this method, 52 pork samples from Beijing markets were tested, and the result showed that all 26 PFASs compounds, except perfluorooctanesulfonamide(PFOSA), were ubiquitous and accumulated to varying degrees in pork.</p><p><strong>Conclusion: </strong>This method is simple, time-saving, and has high accuracy, sensitivity, and reliability, making it suitable for simultaneous determination of 27 PFASs in pork samples and applicable to routine monitoring and quality control of PFASs in pork samples.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"510-519"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pollution characteristics and health risk assessment of indicator polychlorinated biphenyls in aquatic products in 10 provinces of China].","authors":"Lingjun Zhang, Xiao Liu, Sheng Wen, Jie Gao, Dajin Yang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.025","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.03.025","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the pollution levels and characteristics of indicator polychlorinated biphenyls(PCBs) in aquatic products and assess the health risk of residents in 10 provinces of China.</p><p><strong>Methods: </strong>A total of 629 aquatic product samples were collected from 10 provinces of China in 2023, including freshwater fish, marine fish and bivalves. The concentrations of seven indicator PCBs in aquatic products were determined by isotope dilution gas chromatography-mass spectrometry, and the pollution characteristics were analyzed. Based on food consumption data in each province, the dietary exposure of indicator PCBs was calculated by the point estimate model to assess the health risks.</p><p><strong>Results: </strong>The detection rate of Σ_7PCBs in aquatic products was 77.1%. The concentrations of Σ_7PCBs in aquatic products were ND-19.6 ng/g, with a mean concentration of 0.509 ng/g. The mean concentrations of Σ_7PCBs in marine fish was higher than those of bivalves and freshwater fish. In most provinces, the most predominant category was found to be PCB153 and PCB138. The mean levels of exposure to Σ_7PCBs through aquatic products for the general population in the 10 provinces ranged from 0.0473 ng/(kg·BW· d) to 1.61ng/(kg·BW·d), which was less than the tolerable daily intake(TDI). The mean exposure levels of Σ_7PCBs in eastern coastal regions were higher than those in inland regions.</p><p><strong>Conclusion: </strong>The level of indicator PCBs in aquatic products in 10 provinces of China was at a low level, and the health risk of dietary exposure for the general population was within an acceptable range.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"520-526"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect evaluation of comprehensive environmental health intervention on health knowledge, attitude and practice of community residents on air pollution].","authors":"Dan Ye, Jiahua Dong, Jingyi Liu, Yu Chen, Xu Yan, Mingxue Zhang, Jiao Wang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.017","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.03.017","url":null,"abstract":"<p><strong>Objective: </strong>To understand the current status of residents&apos; knowledge-attitudes-practice(KAP)towards air pollution and environmental health in four cities, and to evaluate the effectiveness of interventions.</p><p><strong>Methods: </strong>Using cluster sampling, a comprehensive intervention targeting KAP regarding air pollution and environmental health was conducted among 2431 adult residents in Beijing City, Yichang City, Dandong City and Lhasa City in 2023. Baseline surveys and effectiveness evaluation surveys were conducted before and after the intervention.</p><p><strong>Results: </strong>After intervention, the KAP scores of residents in the four cities were 86.27±10.49, which was higher than the intervention score of 70.00±14.60(χ~2=61.48, P&lt;0.01). After intervention, the scores for the three dimensions of KAP were 30.64±3.23, 24.28±3.78 and 31.34±6.44, respectively. There were statistically significant differences in the levels of KAP in knowledge, attitudes, and practice before and after the intervention(χ~2 values were 46.84, 37.84 and 49.94, respectively, P&lt;0.01). After intervention, the overall level of KAP, as well as the average level of KAP in three dimensions, improved among different populations, and the difference was statistically significant. The difference after intervention was greater in Dandong City(24.27±12.95, P&lt;0.01) than in Beijing City(15.64±11.44, P&lt;0.01), Lhasa City(15.23±12.53, P&lt;0.01), and Yichang City(10.02±11.10, P&lt;0.01). The difference was also greater in males(16.72±13.41, P&lt;0.01) than in females(15.967±12.80, P&lt;0.01). Additionally, the improvement was more significant among individuals aged 60 and above(20.20±12.86, P&lt;0.01) compared to those aged 46-60(17.99±12.70, P&lt;0.01) and those aged 18-45(12.86±12.53, P&lt;0.01). Furthermore, the improvement was more pronounced among individuals with junior high school education(21.08±12.59, P&lt;0.01) compared to those with primary school and below education(17.49±13.06, P&lt;0.01), vocational school/high school education(16.06±12.38, P&lt;0.01), college/undergraduate education(12.44±12.61, P&lt;0.01), and master&apos;s degree and above education(10.36±10.49, P&lt;0.01).</p><p><strong>Conclusion: </strong>Comprehensive intervention measures are an effective means to enhance the KAP of community residents regarding air pollution and environmental health.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"465-477"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevalence and associated factors for double burden of overweight/obesity and anemia malnutrition among children aged 6-71 months in China in 2019-2021].","authors":"Mingjia Luo, Xuehong Pang, Shan Jiang, Tao Xu, Bowen Chen, Yuying Wang, Qian Zhang, Wenhua Zhao, Zhenyu Yang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.007","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.03.007","url":null,"abstract":"<p><strong>Objective: </strong>To provide updated prevalence and associated factors of double burden of malnutrition(DBM) among children aged 6-17 months in China.</p><p><strong>Methods: </strong>This study was a cross-sectional study. A multi-stage stratified randomized sampling method was used to recruit 25 791 children aged 6-71 months from 14 provinces in China between 2019 and 2021. A standardized questionnaire survey was used to collect basic information about children and their parents. All children were weighted using unified digital weight scales, and the length/height of all children was determined using unified instruments. Hemoglobin of all children was collected using a HemoCue 201+ system. The body mass index for age Z-scores and anemia were determined and used to evaluate the prevalence of double burden of overweight/obesity and anemia malnutrition. The chi-square test was used to compare the prevalence of malnutrition among children with different characteristics. The unconditional logistic regression model was used to examine factors associated with the malnutrition.</p><p><strong>Results: </strong>This study included 25 791 children aged 6-71 months, including 5127 children aged 6-11 months, 6592 children aged 12-23 months, 3605 children aged 24-35 months, 3492 children aged 36-47 months, 3559 children aged 48-59 months, and 3416 children aged 60-71 months. The prevalence of double burden of overweight/obesity and malnutrition among children aged 6-71 months was 0.8%(n=210).12-23 months(OR=0.69, 95%CI 0.42-0.83), 24-35 months(OR=0.33, 95%CI 0.19-0.55), 36-47 months(OR=0.14, 95%CI 0.06-0.30), 48-59 months(OR=0.26, 95%CI 0.14-0.48), 60-71 months(OR=0.46, 95%CI 0.28-0.75), father&apos;s age of 40-44years(OR=0.40, 95%CI 0.17-0.97) and higher education levels of father(OR=0.40, 95%CI 0.17-0.97) were the protective factors for DBM(P&lt;0.05), whereas large-for-gestational-age infants(LGA)(OR=1.73, 95%CI 1.13-2.66), non-only-child(OR=1.58, 95%CI 1.14-2.19), central regions(OR=1.64, 95%CI 1.11-2.43) and rural area(OR=1.45, 95%CI 1.05-2.00)were the risk factors for DBM(P&lt;0.05).</p><p><strong>Conclusion: </strong>The prevalence of DBM among children aged 6-71 months in 14 provinces in China was at a relatively low level. The occurrence of overweight/obesity and anemia malnutrition was impacted by children age, LGA, non-only-child, age of father, education levels of father and regions.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"397-404"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nutritional risk investigation and related factors of 197 patients with early-stage non-small cell lung cancer].","authors":"Jing Ai, Yuping Du, Chonglin Wang, Yao Liu, Ji Liu, Fei Wu, Zheng Gu, Jinmei Zheng, Licui Sun, Qiang Su","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.014","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.03.014","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the nutritional risk status of patients with non-small cell lung cancer(NSCLC), and to analyze the factors that may cause the nutritional risk of NSCLC patients.</p><p><strong>Methods: </strong>A total of 197 patients with non-small cell lung cancer(NSCLC) who were admitted to the Department of Oncology of Beijing Friendship Hospital, Capital Medical University from January 2023 to January 2024 were selected as the study subjects, and the nutritional status of 197 non-small cell patients was measured and evaluated by the Nutritional Risk Screening Scale(NRS 2002), and Analysis of the related factors of nutritional risk in patients with non-small cell lung cancer.</p><p><strong>Results: </strong>Among 197 patients with early-stage non-small cell lung cancer, 13(6.60%) had a nutritional risk score of ≥3 points. Univariate analysis result showed that age, lesion size, body mass index(BMI), hemoglobin level, and smoking and hypertension history were related factors for nutritional risk in non-small cell lung cancer patients(P&lt;0.05). Multivariate analysis result indicated that BMI level was a protective factor for nutritional risk in non-small cell lung cancer surgery patients(OR=0.51, 95%CI 0.38-0.70, P&lt;0.01).</p><p><strong>Conclusion: </strong>The incidence of nutritional risk exists among patients with early-stage non-small cell lung cancer. The patient&apos;s age, lesion size, hemoglobin level, BMI, and whether they have a history of smoking or hypertension are related factors for the patient&apos;s nutritional risk. BMI is a protective factor for the nutritional risk of non-small cell lung cancer patients.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"444-448"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Protective effects of 5-n-alkylresorcinols on H_2O_2-induced oxidative damage in Caco-2 cells].","authors":"Zhixuan Fan, Zhaolong Gong, Chen Chen, Jingbo Wang, Liyuan Wang, Wen Qin, Qin Zhuo, Jing Luan, Zhuo Yang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.012","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.03.012","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the protective effects of five alkylresorcinol homologs on hydrogen peroxide(H_2O_2)-induced oxidative damage in human colorectal adenocarcinoma cells(Caco-2).</p><p><strong>Methods: </strong>The H_2O_2-induced oxidative damage of Caco-2 cells was used as a model, and the survival rate of Caco-2 cells pretreated with different concentrations(0-80 μmol/L)of 5-n-alkylresorcinols was determined to determine the optimal concentration range. The protective effects of 5-n-alkylresorcinols on oxidative-damaged cells was evaluated by measuring the levels of reactive oxygen species(ROS), malondialdehyde(MDA), glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) activities.</p><p><strong>Results: </strong>5-n-alkylresorcinols had no obvious toxic effect on Caco-2 cells in the concentration range of 5-80 μmol/L. The activities of GSH-Px, SOD and CAT oxidase in cell culture supernatant and cells were significantly lower than those in the control group after 4 hours of 600 μmol/L H_2O_(2 )treatment(P&lt;0.05). The addition of 5 alkylresorcinol homologues at different concentrations alleviated the damage of H_2O_2 to different degrees, and the ROS level and MDA content decreased compared with the modularity, and the activity of GSH-Px, SOD and CAT was restored to a certain extent.</p><p><strong>Conclusion: </strong>5-n-alkylresorcinols can protect Caco-2 cells from oxidative damage to H_2O_2 by activating intracellular antioxidant enzyme activity and inhibiting lipid peroxidation levels.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"434-438"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Relationship between maternal pre-pregnancy obesity and infant development: the Taicang and Wuqiang mother-child cohort study in China].","authors":"Xinxin Xing, Yifan Duan, Zhenyu Yang, Ye Bi, Changqing Liu, Yongli Zhao, Xuyang Gu, Jingtao Duan, Hua Zhao, Jianqiang Lai","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.009","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.03.009","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effects of maternal pre-pregnancy obesity on infant development.</p><p><strong>Methods: </strong>Pre-pregnancy obese pregnant women who gave birth in Wuqiang County Hospital from October 2017 to October 2021 were selected, and pregnant women with normal weight before pregnancy were matched by propensity score. A total of 206 pregnant women were included, including 103 in the pre-pregnancy obesity group and 103 in the pre-pregnancy normal weight group. The basic characteristics of pregnant women and birth information of newborns were investigated through hospital medical record system. The weight and length were measured at birth, at 1 month, 3 months, 6 months and 12 months of age. The mixed effects model was used to analyze the effects of pre-pregnancy obesity on infant development.</p><p><strong>Results: </strong>There were no significant differences between the two groups in maternal age, education level, gestational age, birth time and sex of the newborn(P&gt;0.05). The birth weight of the obese group was significantly higher than that of the normal weight group(3541.89 g vs.3296.60 g, P&lt;0.01). The result of repeated measurement analysis showed that after adjusting for maternal age, gestational weight gain, delivery mode and newborn sex, the effects of pre-pregnancy obesity and infant age on infant body mass index for age Z-score(BAZ), weight for length Z-score(WLZ) and weight for age Z-score(WAZ) were statistically significant(P&lt;0.05). However, maternal obesity and infant age did not affect the level of length for age Z-score(LAZ)(P&gt;0.05). The mean values of BAZ, WLZ and WAZ in the obese group were 0.434, 0.422 and 0.316 higher than those in the normal weight group, respectively.</p><p><strong>Conclusion: </strong>Maternal pre-pregnancy obesity increases BAZ, WLZ and WAZ of the offspring in infancy.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"412-418"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of the Delphi method to establish index system for evaluating nutritional status of women before and during pregnancy].","authors":"Hongli Dong, Danping Su, Hong Sun, Fei Li, Yiqi Zhang, Xi Lan, Ming Li, Ju Zhang, Yan Gao, Huan Zhou, Guo Zeng","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.015","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.03.015","url":null,"abstract":"<p><strong>Objective: </strong>To establish index system for evaluating nutritional status of women before and during pregnancy.</p><p><strong>Methods: </strong>Preliminary construction of this index system was based on literature review, grass-roots investigation and expert discussions. The Delphi method was applied to conduct two rounds of consultation with 25 experts. The active coefficient, authority coefficient, concentration coefficient and harmony coefficient were analyzed after consultation. Then the index system was finally formed based on the criteria for screening indicators and combining the experts&apos; opinions and suggestions as well as the discussions of the research team.</p><p><strong>Results: </strong>The active coefficients of the consultation in two rounds were both 100%. The authority coefficients were(0.95±0.06) and(0.96±0.06). The ranges of average scores for importance of second-level indicators were(3.44-5.00) and(4.04-5.00), for feasibility of second-level indicators being(3.36-5.00) and(3.64-5.00). The harmony coefficients for importance of second-level indicators were 0.277(χ~2=338.26, P&lt;0.05) and 0.300(χ~2=292.50, P&lt;0.05), and for feasibility of second-level indicators were 0.308(χ~2=359.21, P&lt;0.05) and 0.404(χ~2=377.84, P&lt;0.05), respectively. Finally, the index system was established with 5 first-level and 39 second-level indicators.</p><p><strong>Conclusion: </strong>Constructing a system of indicators for evaluating the nutritional status of women before and during pregnancy based on Delphi method showed a performance of good activism and authority of experts. Experts&apos; opinions were coordinated and unified, indicating this index system was relatively reliable.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"449-454"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}