卫生研究最新文献

{"title":"[Changing trends of waist circumference and central obesity among adult residents in Xinjiang Uygur Autonomous Region from 2002 to 2015].","authors":"Abudusilimu Maidina, Hongyun Fang, Qiya Guo, Chunmei Ling, Lahong Ju, Shujuan Li, Jun Zhang, Xue Cheng, Xiaoqi Wei, Xiaoli Xu, Wenwen Du, Jiguo Zhang, Huijun Wang, Weiyi Gong","doi":"10.19813/j.cnki.weishengyanjiu.2026.02.004","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.02.004","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the changing trends of waist circumference and central obesity among adult residents in Xinjiang Uygur Autonomous Region from 2002 to 2015.</p><p><strong>Methods: </strong>A multi-stage stratified cluster sampling method was adopted to select the relevant data of residents aged 18 and above from the three cross-sectional surveys of \"China Nutrition and Health Surveillance\" conducted in 2002, 2012 and 2015. Pre-central obesity and central obesity were defined according to the Chinese Adult Weight Determination Criteria(WS/T 428-2013). Compared the waist circumference, the rate of central obesity and their changing trends among different genders, ages and urban-rural groups.</p><p><strong>Results: </strong>From 2002 to 2015, the average waist circumference of adult residents in Xinjiang Uygur Autonomous Region increased from 78.3 cm to 85.9 cm(P&lt;0.01), The average waist circumference of men increased from 80.3 cm to 88.3 cm, and that of women increased from 76.4 cm to 83.6 cm. The average waist circumference of residents aged 18-44, 45-59, and 60 and above increased from 76.2 cm, 83.0 cm, and 80.0 cm to 83.7 cm, 87.7 cm, and 87.9 cm, respectively. The rate of central obesity increased from 19.6% to 44.1%(P&lt;0.01), with men increasing from 19.4% to 44.7% and women from 19.9% to 43.5%. The rate of central obesity of residents aged 18-44, 45-59, and 60 and above increased from 12.9%, 35.8%, and 24.9% to 36.2%, 50.3%, and 51.1% respectively. The growth rate was more significant among men and residents aged 60 and above. In 2002, there was no data on the waist circumference of urban residents. The average waist circumference of rural residents increased from 82.6 cm in 2012 to 85.1 cm in 2015. While the average waist circumference of urban residents decreased from 87.6 cm in 2012 to 86.9 cm in 2015. The central obesity rate among rural residents rose from 30.4% in 2012 to 40.9% in 2015. Meanwhile, the central obesity rate among urban residents dropped from 51.7% in 2012 to 47.9% in 2015. The gap between urban and rural areas in waist circumference and central obesity rates has narrowed. The CMH trend test showed that the grades of central obesity(normal, pre-obesity, obesity) significantly increased with the years of investigation(trend χ~2=500.50, P&lt;0.01), indicating that central obesity among adult residents in Xinjiang Uygur Autonomous Region showed a progressive aggravation trend from 2002 to 2015.</p><p><strong>Conclusion: </strong>From 2002 to 2015, the waist circumference and central obesity rate of adult residents in Xinjiang Uygur Autonomous Region showed a significant upward trend, and health intervention needs to be strengthened.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 2","pages":"195-200"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between screen time, sugar-sweetened beverage intake and different types of obesity among primary and secondary school students in Jiangsu Province in 2023].","authors":"Peixuan Li, Xiyan Zhang, Yiliang Xin, Jie Yang, Yan Wang","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.009","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.009","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the relationship between screen time, sugar-sweetened beverage(SSB) intake and different types of obesity(obesity defined by body mass index(BMI), abdominal obesity and high BMI combined with high waist circumference(WC)).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Relying on the 2023 Surveillance and Intervention Project for Common Disease and Health Risk Factors among Students in Jiangsu Province, stratified random cluster sampling method was used to select a total of 142 113 primary and secondary school students from 13 cities in Jiangsu Province. Students&apos; height, weight, and WC were collected through physical examinations. In accordance with the requirements of Screening for Overweight and Obesity in School-Age Children and Adolescents(WS/T 586-2018) and High Waist Circumference Screening Threshold among Children and Adolescents Aged 7-18 Years(WS/T 611-2018), different types of obesity were determined based on the above-mentioned indicators. General demographic information of students(including gender, school stage, place of residence, etc. ) and behavioral lifestyle information(including screen time, SSB intake, etc. ) were collected via questionnaires. Binary Logistic regression was used to analyze the association between screen time and SSB intake and different types of obesity in primary and secondary school students.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In 2023, among primary and secondary school students in Jiangsu Province, boys accounted for 52.1%(n=74 053) and girls accounted for 47.9%(n=68 060); primary school students accounted for 33.5%(n=47 568), junior high school students accounted for 33.3%(n=47 408), and senior high school students accounted for 33.2%(n=47 137); students in urban areas accounted for 55.8%(n=79 293) and students in suburban and county areas accounted for 44.2%(n=62 820). The detection rate of obesity defined by BMI, abdominal obesity and high BMI combined with high WC among primary and secondary school students in Jiangsu Province was 19.6%(n=27 859), 30.2%(n=42 865), and 18.1%(n=25 707), respectively. Screen time of ≥2 h/d is associated with an increased risk of obesity defined by BMI(OR=1.14, 95% CI 1.10-1.18), abdominal obesity(OR=1.09, 95% CI 1.06-1.12), and high BMI combined with high WC(OR=1.15, 95% CI 1.11-1.20) among primary and secondary school students. SSB intake ≥ 1 time/d is associated with an increased risk of obesity defined by BMI(OR=1.10, 95% CI 1.05-1.15), abdominal obesity(OR=1.10, 95% CI 1.05-1.14), and high BMI combined with high WC(OR=1.12, 95% CI 1.07-1.18) among primary and secondary school students. Compared with the control group(screen time&lt;2 h/d + SSB intake&lt;1 time/d), students in Group 1(screen time ≥2 h/d + SSB intake&lt;1 time/d), Group 2(screen time&lt;2 h/d + SSB intake ≥ 1 time/d), and Group 3(screen time ≥ 2 h/d + SSB intake ≥ 1 time/d) all had an increased risk of different types of obesity. Specifically: Group 1: For obesity defined by","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"43-50"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Extraction of protective dietary pattern for remnant cholesterol among adult in China in 2015-2017].","authors":"Fusheng Li, Shuya Cai, Wei Piao, Yuxiang Yang, Jing Nan, Liyun Zhao, Dongmei Yu","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.008","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.008","url":null,"abstract":"<p><strong>Objective: </strong>To analyze and identify protective dietary patterns for reducing remnant cholesterol levels in Chinese adult residents, and to analyze the energy and nutrient intake of different compliance groups.</p><p><strong>Methods: </strong>The data for this study was obtained from the China Residents Nutrition and Health Survey(2015-2017). The sampling method used was stratified, multi-stage, and random sampling. A total of 61 317 residents aged 18 and over from 298 monitoring sites across the country were included in the study. The remnant cholesterol levels were estimated using internationally recognized method. The protective dietary patterns were identified using the principal component regression method.</p><p><strong>Results: </strong>The protective dietary patterns for remnant cholesterol in Chinese adult residents are characterized by a higher intake of fresh vegetables, fresh fruits, fungi and algae, and soybean products, and a lower intake of refined grains and alcoholic beverages. This dietary pattern explains 8.24% of the variability in food groups and 53.69% of the variability in the response variable. In the correlation analysis, the dietary score was found to have a negative correlation with explanatory variables that had negative factor loadings, and a positive correlation with explanatory variables that had positive factor loadings. These correlations were statistically significant(P&lt;0.01). The response variables also showed a positive correlation(P&lt;0.01), with dietary fiber having the strongest correlation with vitamin E intake(r=0.73, P&lt;0.01) and a strong positive correlation with calcium intake(r=0.71, P&lt;0.01). Additionally, there was a significant positive correlation between the response variable and dietary score(P&lt;0.01). The highest correlations were found between dietary score and dietary fiber(r=0.78, P&lt;0.01) and vitamin E(r=0.75, P&lt;0.01). In the nutrient analysis, the high compliance group showed higher intakes of protein, fat, carbohydrates, dietary fiber, cholesterol, total vitamin A, beta-carotene, retinol, thiamine, vitamin C, vitamin E, calcium, phosphorus, potassium, sodium, magnesium, iron, zinc, selenium, copper, and manganese, and lower intakes of energy, thiamine, and niacin. The median energy intake of the Q5 group decreased by 596.08 kcal/d compared to the Q1 group. Additionally, the median protein intake increased by 2.01 g/d, while the fat intake decreased by 0.60 g/d. However, the carbohydrate intake increased by 29.99 g/d.</p><p><strong>Conclusion: </strong>There are significant differences in energy and nutrient intake among the compliance groups of the protective dietary patterns for remnant cholesterol in Chinese adult residents. This highlights the importance of a balanced and nutrient-rich diet in reducing remnant cholesterol levels.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"35-50"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Screening of differential metabolites and metabolic pathways in pregnant women with gestational diabetes mellitus during the second trimester].","authors":"Yun Liu, Lanlan Xiang, Meimei Hu, Yitian Zhu, Shuyu Li, Yajun Chen, Tianying Zhong, Yu Zeng","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.017","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.017","url":null,"abstract":"<p><strong>Objective: </strong>To analyze serum differential metabolites and related metabolic pathways following a glucose load during the second trimester in pregnant women with gestational diabetes mellitus(GDM) using untargeted metabolomics.</p><p><strong>Methods: </strong>Pregnant women who registered at Nanjing Maternity and Child Health Care Hospital between April and May 2020 were selected and divided into a GDM group and a control group(CON), with 15 participants in each group, based on the result of the oral glucose tolerance test(OGTT). Serum samples were collected at 0 h and 1 h during the OGTT and analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) for untargeted metabolomic profiling. Differential metabolites were identified through t-tests, principal component analysis, and orthogonal partial least squares-discriminant analysis. The identified metabolites were annotated using KEGG database, and pathway enrichment analysis was performed on the MetaboAnalyst 5.0 platform.</p><p><strong>Results: </strong>A total of 166 and 134 metabolites were identified in the positive and negative ion modes, respectively. Multivariate analysis revealed significant differences in metabolic profiles among the groups(P&lt;0.05). In the four comparative groups-CON-0 h vs CON-1 h, GDM-0 h vs GDM-1 h, CON-0 h vs GDM-0 h, and CON-1 h vs GDM-1 h-53, 55, 17 and 31 differential metabolites were identified, respectively. Lipids and lipid-like molecules constituted the predominant category, accounting for 43.3%, 45.4%, 35.2% and 41.9% of the differential metabolites, respectively. These metabolites were significantly enriched in pathways such as arginine biosynthesis; alanine, aspartate, and glutamate metabolism; and sphingolipid metabolism(P&lt;0.05).</p><p><strong>Conclusion: </strong>Significant alterations in serum metabolic profiles were observed in women with GDM after a glucose load during the second trimester. The differential metabolites were primarily lipids and lipid-like molecules, mainly involved in amino acid metabolism and sphingolipid metabolism-related pathways.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"98-106"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Allergenic protein content in high-molecular-weight glutenin from genetically edited wheat by ultra-performance liquid chromatography-mass spectrometry].","authors":"Xin Shen, Xi Chen, Yi Yang, Qin Zhuo, Shi Shen","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.019","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.019","url":null,"abstract":"<p><strong>Objective: </strong>To establish a qualitative and quantitative method for detecting allergenic proteins in wheat based on the high-molecular-weight(HMW) glutenin Tri a 26, and to analyze and compare the allergenic protein content between genetically edited wheat and conventional control wheat samples.</p><p><strong>Methods: </strong>The allergenic protein Tri a 26 was selected as the target protein, and its specific peptide IFWGIPALLK was identified and artificially synthesized. Wheat samples were homogenized and extracted with 100 mmol/L Tris-HCl buffer(pH 8.5) containing 4 mol/L urea and 0.1 mol/L dithiothreitol. After alkylation of cysteine residues, the extracts were digested with trypsin at 37 ℃ for 16 h. Quantification was performed using multiple reaction monitoring in positive-ion mode via dart spray ionization, with an external standard method. The Tri a 26 content in genetically edited wheat and conventional control wheat was measured and compared.</p><p><strong>Results: </strong>The standard solution of the specific hydrolyzed peptide exhibited good linearity in the range of 10-2000 ng/mL(r&gt;0.999). The limit of quantification(LOQ) for the IFWGIPALLK peptide in the sample was 0.328 ng/g. The spike recovery rates at three concentration levels ranged from 84.8% to 95.4%(n =6), with relative standard deviations(RSDs) between 2.99% and 6.12%. The Tri a 26 content in genetically edited wheat and conventional control wheat ranged from 1.976 to 2.069 mg/g.</p><p><strong>Conclusion: </strong>This method demonstrates high sensitivity and specificity and can be effectively applied to the detection of HMW glutenin in wheat. The study found that the Tri a 26 content in genetically edited wheat was not higher than that in conventional control wheat.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"110-116"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Status and distribution of blood pressure among Chinese children and adolescents aged 7-17 from 2016 to 2017].","authors":"Yuge Li, Mulei Chen, Shuya Cai, Fusheng Li, Jing Nan, Yuxiang Yang, Wei Piao, Liyun Zhao, Dongmei Yu","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.007","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.007","url":null,"abstract":"<p><strong>Objective: </strong>To describe the mean of systolic blood pressure(SBP), diastolic blood pressure(DBP), and distribution of blood pressure among 7-17 years old children and adolescents in China from 2016 to 2017.</p><p><strong>Methods: </strong>Data was from the China Nutrition and Health Surveillance of Children and Lactating Women(2016-2017). A total of 67 231 children and adolescents aged 7-17 years old were included in the final analysis through the method of multi-stage stratified cluster randomization sampling and probability proportion to size. Blood pressure was measured three times by qualified staff according to a standardized procedure using the automatic oscillometric method. The average blood pressure was calculated for the three measurements for SBP and DBP. All values were weighted to represent the total population of Chinese childrenand adolescents 6-17 years of age based on Chinese Census 2010.</p><p><strong>Results: </strong>Among Chinese children and adolescents 7-17 years of age, the mean values of SBP and DBP were 112.28 mmHg and 66.68 mmHg, respectively. The SBP and DBP were higher in children and adolescents who were overweighted or with central obesity than those who were not.</p><p><strong>Conclusion: </strong>The mean value of SBP and DBP in Chinese children and adolescents aged 7-17 was increased with age.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Relationship between dietary patterns and obesity among adult residents in six regions of Guizhou Province in 2023].","authors":"Jiangjiang Peng, Linjuan He, Yiya Liu","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.010","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.010","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the relationship between dietary patterns and obesity among adult residents aged 18 years and older in six regions of Guizhou Province in 2023.</p><p><strong>Methods: </strong>The data were derived from the 2023 China Development and Nutrition Health Impact Cohort Survey in Guizhou Province, which used a multistage stratified cluster random sampling method to identify the survey population, and the questionnaire was used to collect basic personal information and dietary data on food frequency, and the physical examination was used to collect data on height and weight. The Chi-Square test was used to compare the differences in the proportion of obese people among different characteristics, and the Wilcoxon rank test was used to compare the differences in energy intake between obese and non-obese people; dietary patterns were established based on exploratory factor analysis, and factor scores were categorized into five categories at the quartile level(Q1-Q5); and binary Logistic regression was used to conduct the analysis of associations between different dietary patterns and obesity.</p><p><strong>Results: </strong>A total of 730 adult residents were included in the analysis of this study, and the obese population amounted to 129(17.67%), of which, males(18.54%), 45-59-year-olds(18.66%), rural population(19.28%), junior high school-educated population(21.67%), smokers(20.63%), alcohol-drinking population(20.90%), moderate physical activity population(19.54%) had a higher prevalence of obesity, but none of the differences were statistically significant. Three types of dietary patterns were established by exploratory factor analysis, namely, non-meat-balanced pattern, salted vegetables-fermented soybean products-meat-rice&amp;noodles pattern, and high salt-oil-sugar pattern. The result of multi-factorial Logistic regression analysis showed that after adjusting for gender, age, region, education, smoking, alcohol consumption, physical activity, and energy intake, the salted vegetable-fermented soybean product-meat-rice&amp;noodle pattern(Q4 vs. Q1: OR=2.574, 95% CI 1.306-5.076) and the high salt-oil-sugar pattern(Q5 vs. Q1: OR=2.175, 95% CI 1.169-4.046) were positively associated with obesity.</p><p><strong>Conclusion: </strong>salted vegetable-fermented soybean product-meat-rice&amp;noodle pattern and high salt-oil-sugar dietary patterns were positively associated with obesity among adult residents in six regions of Guizhou Province.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"51-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Validity and reliability of the nutrition knowledge questionnaire for Chinese school-aged children].","authors":"Yujie Qiu, Caicui Ding, Yan Zhang, Yue Dai, Xiaohui Li, Ailing Liu","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.002","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.002","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and validate the nutrition knowledge questionnaire for Chinese school-aged children.</p><p><strong>Methods: </strong>In September 2023, a convenience sampling method was used to select one primary school, one junior high school, and one senior high school respectively in Suqian City&apos;s Sucheng District of Jiangsu Province and Dayi County of Chengdu City in Sichuan Province for a questionnaire survey. The questionnaire&apos;s reliability(Cronbach&apos;s alpha, split-half reliability) and validity(face validity, structural validity) were evaluated using quantitative method.</p><p><strong>Results: </strong>A total of 1017 participants took part in the survey, including 251 lower-grade primary school students(grades 1-3), 249 upper-grade primary school students(grade 4 and above), 262 junior high school students, and 255 senior high school students. Among them, 480(47.2%) were from urban areas, 473(46.5%) were male, and the mean age was(11.9±3.6) years. The Cronbach&apos;s α coefficients for the four versions of the questionnaire were 0.54, 0.76, 0.79 and 0.79, respectively. The Guttman split-half coefficients were 0.58, 0.63, 0.66 and 0.72, respectively. Validity analysis indicated that the investigators and teachers generally approved of the questionnaire design. In the confirmatory factor analysis, the chi-square/degrees of freedom(χ~2/df) ranged from 1.49 to 1.66, the root mean square error of approximation(RMSEA) ranged from 0.04 to 0.05, and the goodness-of-fit index(GFI) ranged from 0.88 to 0.92. The correlations between each dimension and the total score were significantly higher than the correlations between the dimensions themselves.</p><p><strong>Conclusion: </strong>The lower primary school version of the questionnaire requires further refinement. In contrast, the versions for upper primary, junior high, and senior high school demonstrate satisfactory validity and reliability with well-structured dimensions, making them appropriate for assessing nutrition knowledge and supporting related research among students in the corresponding educational stages.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"2-7"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Isotemporal substitution analysis of 24-hour activity behaviors and health-related physical fitness in university students].","authors":"Yunfeng Song, Liquan Cao, Sijie Tan, Kaixin Li, Yugang Qi","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.011","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.011","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study examined the associations between 24-hour movement behaviors and health-related fitness in university students, and estimated the substitution effects using a compositional isotemporal substitution model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study was conducted between May and June 2023, using a combination of convenience and random sampling to recruit 325 undergraduate students from Tianjin University of Science &amp; Technology as participants, including 167 males and 158 females. Daily 24-hour activity behaviors were measured using a triaxial accelerometer(ActiGraph GT3X+), including moderate-intensity physical activity(MPA), vigorous-intensity physical activity(VPA), light-intensity physical activity(LPA), sedentary behaviors(SB), and sleep(SLP) duration. Body composition was assessed via body mass index(BMI), waist circumference, and body fat percentage. Muscular strength was measured by handgrip strength, cardiorespiratory fitness was measured by vital capacity and maximum oxygen uptake(VO_(2 max)), and flexibility was assessed by the sit-and-reach test. Compositional data analysis was used to investigate the associations between activity behaviors and health-related physical fitness. A 15-minute isotemporal substitution model was applied to predict the effects of replacing one activity with another on outcome variables.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The mean age of male participants was(19.74±1.16) years, and that of female participants was(19.51±1.29) years. Based on 24-hour compositional activity behavior analysis, college students spent an average of 16.42 minutes(1.14% of the day) in MPA, 26.57 minutes(1.85%) in VPA, 150.92 minutes(10.48%) in LPA, 645.78 minutes(46.05%) in SB, and 561.31 minutes(40.21%) in SLP. After adjusting for covariates including sex and age, isotemporal substitution models revealed that replacing an equivalent amount of sedentary time with MPA was associated with a reduction in BMI by 0.07-0.19 units, body fat percentage by 0.53-0.59 units, waist circumference by 0.16-0.27 cm, an increase in vital capacity by 119.18-152.67 mL, VO_(2 max) by 1.76-1.88 mL/(kg·min), handgrip strength by 0.86-1.46 kg, and sit-and-reach performance by 0.19-0.38 cm. Similarly, increasing VPA led to decreases in BMI by 0.14-0.16 units, body fat percentage by 0.49-0.54 units, waist circumference by 0.12-0.23 cm, increases in vital capacity by 127.45-160.84 mL, VO_(2 max) by 1.91-2.03 mL/(kg·min), handgrip strength by 0.98-1.56 kg, and sit-and-reach by 0.14-0.32 cm. Increasing LPA result ed in BMI increases of 0.11-0.12 units, handgrip strength increases of 0.65 kg, and sit-and-reach increases of 0.21 cm. Increasing SLP was associated with BMI reduction of 0.04 units and waist circumference reduction of 0.09 cm.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;MPA had the most significant effect on improving BMI, body fat percentage, and waist circumference, while VPA was more effective in enhancing cardiores","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"58-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Protective effect of Dendrobium officinale polysaccharide against α-amanitin-induced liver injury in mice based on Bax/Apaf-1/ Caspase-3 apoptosis pathway].","authors":"Chong Zheng, Jianfang Ye, Lei Li","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.021","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.021","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the protective effect of Dendrobium officinale polysaccharides(DOP) on α-amatoxins-induced liver injury in mice and to analyze its regulatory role in the Bax/Apaf-1/Caspase-3 apoptosis signaling pathway.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Sixty SPF-grade Kunming mice, half male and half female, were randomly divided into six groups according to sex and body weight: control group, α-amatoxins model group, and DOP intervention groups at doses of 20, 40, 80 and 160 mg/kg. Mice were administered α-amatoxins 0.6 mg/kg by gavage to induce acute liver injury. Immediately after administration, mice in each intervention group were administered the corresponding concentration of Dendrobium officinale polysaccharide solution by gavage at 6-h intervals for a total of four times. The control group and model group were simultaneously given an equal volume(10 mL/kg) of physiological saline. Mice were sacrificed 24 hours after exposure to the toxin, and blood and liver were collected. Serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), alkaline phosphatase(ALP), and gamma-glutamyltransferase(GGT) levels were measured. Hematoxylin-eosin(HE) staining was used to observe histopathological changes in liver tissue. Real-time quantitative PCR and Western blot were used to detect the expression levels of Bax, Apaf-1, and Caspase-3 mRNA and protein in the liver. The content of reactive oxygen species in the liver was detected by fluorescent probe method. The levels of Bcl-2, cytochrome C, and Caspase-9 in the liver were measured by ELISA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared with the control group, the α-amanita peptide model group showed significantly increased serum ALT, AST, TBIL, ALP and GGT levels, as well as significantly increased liver Bax, Apaf-1, and Caspase-3 mRNA and protein levels, and significantly increased liver reactive oxygen species, cytochrome C and Caspase-9 levels(P&lt;0.05), and significantly decreased liver Bcl-2 levels(P&lt;0.05). After DOP intervention, the serum ALT, AST, TBIL, ALP and GGT levels, as well as the liver Bax, Apaf-1, and Caspase-3 mRNA and protein levels, and significantly decreased liver reactive oxygen species, cytochrome C, and Caspase-9 levels in all groups of mice(P&lt;0.05), and significantly increased liver Bcl-2 levels(P&lt;0.05), and a clear dose-response relationship was observed with increasing DOP dosage(P&lt;0.05). HE staining result showed that the livers of mice in the α-amanita peptide model group exhibited significant hepatocyte edema, necrosis, central venous congestion, and inflammatory cell infiltration. Hepatocyte morphology was disordered, with nuclear pyknosis, fragmentation, and dissolution; some areas showed loss of lobular structure, and the necrotic area was expanded. Different doses of DOP intervention groups showed improvement in liver pathological changes. Especially in the DOP 160 mg/kg group, hepatocyte edema an","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"124-131"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}