Xinxin Xing, Yifan Duan, Zhenyu Yang, Ye Bi, Changqing Liu, Yongli Zhao, Xuyang Gu, Jingtao Duan, Hua Zhao, Jianqiang Lai
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引用次数: 0
Abstract
Objective: To explore the effects of maternal pre-pregnancy obesity on infant development.
Methods: Pre-pregnancy obese pregnant women who gave birth in Wuqiang County Hospital from October 2017 to October 2021 were selected, and pregnant women with normal weight before pregnancy were matched by propensity score. A total of 206 pregnant women were included, including 103 in the pre-pregnancy obesity group and 103 in the pre-pregnancy normal weight group. The basic characteristics of pregnant women and birth information of newborns were investigated through hospital medical record system. The weight and length were measured at birth, at 1 month, 3 months, 6 months and 12 months of age. The mixed effects model was used to analyze the effects of pre-pregnancy obesity on infant development.
Results: There were no significant differences between the two groups in maternal age, education level, gestational age, birth time and sex of the newborn(P>0.05). The birth weight of the obese group was significantly higher than that of the normal weight group(3541.89 g vs.3296.60 g, P<0.01). The result of repeated measurement analysis showed that after adjusting for maternal age, gestational weight gain, delivery mode and newborn sex, the effects of pre-pregnancy obesity and infant age on infant body mass index for age Z-score(BAZ), weight for length Z-score(WLZ) and weight for age Z-score(WAZ) were statistically significant(P<0.05). However, maternal obesity and infant age did not affect the level of length for age Z-score(LAZ)(P>0.05). The mean values of BAZ, WLZ and WAZ in the obese group were 0.434, 0.422 and 0.316 higher than those in the normal weight group, respectively.
Conclusion: Maternal pre-pregnancy obesity increases BAZ, WLZ and WAZ of the offspring in infancy.
目的：探讨孕妇孕前肥胖对婴儿发育的影响。方法：选取2017年10月至2021年10月在武强县医院分娩的孕前肥胖孕妇，与孕前体重正常的孕妇进行倾向评分匹配。共纳入206名孕妇，其中孕前肥胖组103名，孕前正常体重组103名。通过医院病案系统调查孕妇的基本特征和新生儿的出生信息。分别于出生时、1个月、3个月、6个月和12个月时测量体重和体长。采用混合效应模型分析孕前肥胖对婴儿发育的影响。结果：两组产妇年龄、文化程度、胎龄、出生时间、新生儿性别差异均无统计学意义（P>0.05）。肥胖组新生儿出生体重显著高于正常体重组（3541.89 g vs.3296.60 g, p < 0.01）。重复测量分析结果显示，在调整母亲年龄、妊娠体重增加、分娩方式和新生儿性别后，孕前肥胖和婴儿年龄对婴儿体重年龄Z-score（BAZ）、体重长型Z-score（WLZ）和体重年龄Z-score（WAZ）的影响均有统计学意义（P<0.05）。然而，母亲肥胖和婴儿年龄对年龄Z-score（LAZ）长度水平没有影响（P>0.05）。肥胖组的BAZ、WLZ和WAZ均值分别比正常体重组高0.434、0.422和0.316。结论：孕妇孕前肥胖可增加子代婴儿期BAZ、WLZ和WAZ。
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