卫生研究最新文献

{"title":"[Effects of serine and NCT503 on improving abnormal glucose metabolism in C2C12 cells cultured in a high selenium medium].","authors":"Shuo Zhan, Yiqun Liu, Feng Han, Jianrong Wang, Mingyu Zhu, Qin Wang, Zhenwu Huang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.020","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.03.020","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of serine supplementation and the 3-phosphoglycerate dehydrogenase(PHGDH)inhibitor NCT503 on the remodeling of glucose metabolism in C2C12 cells under high-selenium(Se) conditions.</p><p><strong>Methods: </strong>C2C12 cells were divided into four groups: control group, high-selenium control group, serine intervention group, and NCT503 intervention group. After 48 hours of treatment, all cells were stimulated with insulin for 15 minutes. The glucose concentration in the cell culture medium was measured before and after insulin stimulation. The expression levels of selenoproteins: glutathione peroxidase 1 and selenoprotein N, serine synthesis and metabolism enzymes: PHGDH, hydroxy-methyltransferases 1(SHMT1), 5, 10-methylenetetrahydrofolate reductase(MTHFR), methionine synthase(MS), and signaling factors: mammalian target of rapamycin, protein kinase B(AKT), Akt1 kinase phosphorylated on Ser 473, Akt1 kinase phosphorylated on Thr 308, and phosphatidylinositol 3 kinase were assessed by Western blotting.</p><p><strong>Results: </strong>Compared with the high-selenium control group, both the serine and NCT503 intervention groups improved insulin sensitivity in C2C12 cells, as indicated by an increased glucose difference in the culture medium before and after insulin stimulation(P&lt;0.05). In the serine intervention group, the expression of serine synthesis enzyme PHGDH and metabolic enzymes SHMT1 and MS was reduced compared to the high-selenium control group(P&lt;0.05). In the NCT503 intervention group, only the expression of some serine metabolic enzymes(SHMT1 and MS) was decreased compared to the high-selenium control group(P&lt;0.05).</p><p><strong>Conclusion: </strong>Both exogenous serine and the PHGDH inhibitor NCT503 can alleviate high-selenium-induced abnormalities in glucose metabolism in C2C12 cells. However, serine, being a natural component of the human body, can also feedback inhibit the key enzyme PHGDH in serine synthesis.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"488-494"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Relationship between human milk oligosaccharides concentrations and physical growth of infants within the first six months of life].","authors":"Yu Zhou, Shan Jiang, Shuxia Wang, Jingyu Yan, Jie Wang, Yifan Duan, Jianqiang Lai, Zhenyu Yang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.002","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.03.002","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between human milk oligosaccharides(HMOs) levels in healthy mothers and infant physical growth.</p><p><strong>Methods: </strong>Based on a nationally representative, multi-stage stratified sampling cross-sectional survey on human milk composition, 195 lactating women within 6 months postpartum and their infants were enrolled. Human milk oligosaccharide(HMOs) concentrations were quantified using ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS). Infant anthropometric measurements(height, weight, and head circumference) were collected to calculate Z-scores. Associations between HMOs and infant growth were analyzed via general linear models.</p><p><strong>Results: </strong>Total HMOs and total sialylated HMOs in mature breast milk showed negative correlations with weight for length Z-score(WLZ), weight for age Z-score(WAZ), and BMI for age Z-score(BAZ)(β=-0.80 to-0.25, P&lt;0.05). Specifically, 6'-sialyllactosamine(6'-SL), sialyllacto-N-tetraose c(LSTc), and disialyllacto-N-tetraose(DSLNT) demonstrated significant negative associations with WAZ(β=-0.36 to-0.25, P&lt;0.05). Total neutral non-fucosylated HMOs and lacto-N-tetraose(LNT) were also negatively correlated with length for age Z-score(LAZ) and WAZ(β=-0.33 to-0.25, P&lt;0.05). Among secretor+/Lewis+(Se+Le+) mothers, the negative effects of total HMOs and sialylated HMOs on infant WLZ, WAZ, and BAZ were further strengthened(β=-1.22 to-0.48, P&lt;0.05).</p><p><strong>Conclusion: </strong>Specific HMO concentrations in human milk during the first 6 months postpartum are associated with infant growth outcomes. Total HMOs, sialylated HMOs, and neutral non-fucosylated HMOs demonstrate negative associations with weight indicators.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"358-365"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lipid-lowering effect of sodium alginate in patients with hypercholesterolemia].","authors":"Jiawen Zhang, Yan Zhang, Xia Zhang, Qingqing Man, Fang Yang, Yingying Li, Mingyu Zhu, Boyi Fan, Guoliang Tang, Xuesong Xiang","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.021","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.03.021","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of sodium alginate(SA) on serum total cholesterol(TC) levels in individuals with hypercholesterolemia.</p><p><strong>Methods: </strong>A randomized double-blind controlled trial was conducted on hypercholesterolemic patients(TC≥5.2 mmol/L, n=84), who were divided into a control group and an SA intervention group. General demographic and physical examination data were collected. Serum levels of TC, triglycerides(TG), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) were measured before and after the intervention. Changes in TC, TG, LDL-C, and HDL-C were calculated as baseline values minus post-intervention values(28 days), followed by comparative analyses.</p><p><strong>Results: </strong>SA showed no significant effects on body weight or body mass index(BMI). However, SA reduced lipid levels: the ΔTC, ΔTG, and ΔLDL-C in the SA intervention group were higher compared to the control group(P&lt;0.05). The lipid-lowering effects increased with higher baseline TC levels(r=0.476, P&lt;0.001). The participants with TC ≥6.2 mmol/L demonstrated significantly higher ΔTC and ΔLDL-C compared to the control group(P&lt;0.01).</p><p><strong>Conclusion: </strong>Sodium alginate significantly reduces serum TC and LDL-C levels in hypercholesterolemic patients, with particularly pronounced effects in patients with TC≥6.2 mmol/L.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"495-499"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impact of B vitamins in the diet of breastfeeding mother on neuropsychological development of infants aged 6 months old].","authors":"Qianru Xie, Xiaoman Huang, Hongyu Xu, Guohui Xun, Rongrong Shen, Jiahu Hao","doi":"10.19813/j.cnki.weishengyanjiu.2025.03.003","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.03.003","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of B vitamins intake in the diet of breastfeeding mother on infant neurodevelopment.</p><p><strong>Methods: </strong>Study was conducted at Hefei Women and Children&apos;s Health Center from June 2020 to April 2021. A self-designed questionnaire was used at 42 days, 3 months, and 6 months postpartum to survey the dietary intake of breastfeeding mothers. Neurodevelopmental assessments were conducted using the Ages and Stages Questionnaire, 3rd edition(ASQ-3) when infants were 6 months old. General linear models(GLM) were employed to analyze the effects of B-vitamin intake in maternal diet on infant neurodevelopment. Multivariable logistic regression was used to test the consistency of the result.</p><p><strong>Results: </strong>Ultimately, 233 mother-infant pairs were included in this study, of which 113(57.1%) were infants. The birth weight of the infants was(3.52±0.79) kg, and the mean maternal age at delivery was(29.2±3.8) years. No statistically significant association was found between maternal B-vitamin intake at 42 days and infant neuropsychological development(P&gt;0.05). At 3 months, maternal vitamin B_2 intake was significantly positively correlated with the infant&apos;s total problem-solving domain score in the fully adjusted model(β=0.19, 95%CI 0.01-0.36). Vitamin B_9 intake was significantly positively correlated with the total ASQ-3 score and the problem-solving score, and the result remained significant after adjustments(β=0.24, 95%CI 0.08-0.39; β=0.18, 95%CI 0.02-0.34). Logistic regression analysis showed that maternal dietary vitamin B_9 at 6 months was significantly associated with a reduced risk of low level of neural development in overall neurodevelopment(ASQ-3 total score)(OR=0.40, 95%CI 0.21-0.75). At 3 months, maternal vitamin B_2, vitamin B_3 and vitamin B_9 intake was significantly associated with a reduced risk of low level of neural development in the infant&apos;s personal-social, gross motor and personal-social domains(OR=0.14, 95%CI 0.05-0.42; OR=0.32, 95%CI 0.13-0.80; OR=0.45, 95%CI 0.24-0.86, respectively).</p><p><strong>Conclusion: </strong>Maternal dietary intake of B-vitamins at 3 and 6 months, especially vitamin B_9, is positively correlated with infant neuropsychological development.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 3","pages":"366-383"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of nutrient patterns with serum uric acid in elderly across four Chinese provinces from 2018 to 2019].","authors":"Pengfeng Qu, Zhiru Wang, Liusen Wang, Weiyi Li, Hongru Jiang, Jiguo Zhang, Huijun Wang, Bing Zhang, Junhua Han, Aidong Liu, Zhihong Wang","doi":"10.19813/j.cnki.weishengyanjiu.2025.02.008","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.02.008","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between nutrient patterns and serum uric acid levels in the elderly population.</p><p><strong>Methods: </strong>A total of 6288 elderly individuals aged 65 and above were analyzed from the Community-based Cohort Study on Nervous System Diseases baseline survey conducted from 2018 to 2021. Food frequency questionnaires were used to estimate the average daily intake of various foods per person in the past year, based on the frequency and quantity of food consumed per occasion. The average daily consumption of cooking oil and condiments per person was estimated by considering the average monthly household usage of these items and the number of meals prepared at home. Based on the food weights in Dietary Guidelines: Scientific Evidence and Methodological Studies and Chinese Food Composition, daily energy and nutrients intakes were calculated. Nutrient patterns for 24 nutrients, including macronutrients, vitamins and minerals, were extracted using principal component analysis. Quartile regression models were used to analyze the relationship between nutrient patterns and fasting serum uric acid levels.</p><p><strong>Results: </strong>Male elderly, individuals aged ≥75 years, living in rural areas, with junior high school education or above, high income, smokers, drinkers, elderly with low physical activity level, high body mass index(BMI) value or having chronic diseases had significantly higher serum uric acid levels(P&lt;0.05). Four nutrient patterns were extracted: the &apos;carbohydrate-vitamin B_1 pattern&apos;, the &apos;vitamin A-vitamin C pattern&apos;, the &apos;unsaturated fatty acid-vitamin E pattern&apos;, and the &apos;cholesterol pattern&apos;. Each nutrient pattern was divided into four quartiles, with Q1 as the reference. The &apos;unsaturated fatty acid-vitamin E pattern&apos; showed a negative correlation between Q4 and serum uric acid levels at the P10, P25, P50, and P75 quartiles(β-values and 95%CIs:-8.01(-15.55--0.48), -11.33(-17.77--4.89), -15.35(-18.39--5.35), -8.94(-17.46--0.41), P_(trend)&lt;0.05); At the P25 percentile of serum uric acid levels, Q2, Q3, and Q4 were negatively correlated with serum uric acid levels(β-values and 95%CIs:-6.28(-12.49--0.06), -6.86(-12.67--1.06), -11.33(-17.77--4.89), respectively, P_(trend)&lt;0.05). At the P50 percentile of serum uric acid levels, Q3 and Q4 were negatively correlated with blood uric acid levels(β-values and 95%CIs:-7.64(-14.39--0.89), -11.87(-18.39--5.35), respectively, P_(trend)&lt;0.05).</p><p><strong>Conclusion: </strong>The &apos;unsaturated fatty acid-vitamin E pattern&apos; model had a greater impact on intermediate and lower serum uric acid levels in the elderly population, suggesting that targeted dietary interventions may have a lowering effect on intermediate and lower serum uric acid levels.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 2","pages":"222-228"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Trends in the blood pressure distribution and prevalence of hypertension among Chinese adult residents from 1982 to 2015].","authors":"Xue Cheng, Fangxu Guan, Huijun Wang, Qiya Guo, Shujuan Li, Lahong Ju, Xiaoli Xu, Weiyi Gong, Jiguo Zhang, Wenwen Du, Xiaoqi Wei, Hongyun Fang","doi":"10.19813/j.cnki.weishengyanjiu.2025.02.002","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.02.002","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To analyze the trend of blood pressure distribution and hypertension prevalence among adult residents in China from 1982 to 2015.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The data was sourced from six rounds of cross-sectional data: the 1982 National Nutrition Survey, the 1992 National Nutrition Survey, the 2002 China National Nutrition and Health Surveillance, the 2012 China National Nutrition and Health Surveillance, and the 2015 China National Nutrition and Health Surveillance. The study subjects were adult residents aged 18 years and above. Systolic blood pressure≥140 mmHg and/or diastolic blood pressure≥90 mmHg, or those who had taken anti-hypertensive drugs in the past two weeks were defined as hypertension. The prevalence of hypertension was calculated for each round of study subjects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The total number of people surveyed in each round from 1982 to 2015 were 26 718, 7793, 140 404, 117 391 and 172 989, respectively. For adult Chinese residents, the main characteristic of changes in systolic and diastolic blood pressure is a rightward shift in the curve and a wider distribution range. The systolic blood pressure moves more to the right than the diastolic blood pressure, and the distribution range changes more widely. On the 5th, 50th, and 95th percentile curves, systolic blood pressure increases with age for both males and females, with the fastest growth rate observed between the ages of 40 and 60. Diastolic blood pressure first increases and then decreases with age. The higher percentiles of all genders and age groups show more growth. For each percentile curve, the growth rate of males is greater than that of females. The prevalence of hypertension among adult residents in China has been on the rise from 9.6% in 1982 to 28.6% in 2015. The prevalence of hypertension in both males and females is on the rise, with males increasing from 10.9% in 1982 to 31.3% in 2015, and females increasing from 8.2% in 1982 to 25.9% in 2015. In all rounds of monitoring, the prevalence of hypertension in males is higher than that in females. The prevalence of hypertension in various age groups is on the rise. The prevalence of hypertension in the 18-44 age group increased from 5.7% in 1982 to 14.2% in 2015 the prevalence of hypertension in the 45-64 age group increased from 14.8% in 1982 to 42.4% in 2015, and the prevalence of hypertension in the 65-year-old group increased from 25.1% in 1982 to 66.0% in 2015. Moreover, the prevalence of hypertension increases with age. The prevalence of hypertension in both urban and rural areas is on the rise. The prevalence of hypertension in urban areas has increased from 10.5% in 1982 to 26.3% in 2015, while in rural areas it has increased from 9.0% in 1982 to 31.3% in 2015. Starting from 2015, the prevalence of hypertension in rural areas has surpassed that in urban areas. The prevalence of hypertension in both the normal and overweight/obese populations is on the ris","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 2","pages":"181-200"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Preparation and physicochemical properties of double aldehyde starch microcapsules loaded with tea polyphenols].","authors":"Junwei Fan, Yanhao Liu, Yang Wang, Zhenyu Wang, Lu Wang","doi":"10.19813/j.cnki.weishengyanjiu.2025.02.018","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.02.018","url":null,"abstract":"<p><strong>Objective: </strong>To achieve high-value and functional applications of Mongolian oak starch resources.</p><p><strong>Methods: </strong>Dialdehyde Mongolian oak starch was prepared by modifying Mongolian oak starch with NaIO_4, using the degree of aldehyde substitution as an indicator to study the oxidation conditions. The dialdehyde Mongolian oak starch was then combined with gum arabic to create a composite wall material for encapsulating tea polyphenols, and the reaction conditions were optimized through PB tests and response surface analysis to investigate the encapsulation efficiency and sustained release properties of the polyphenols.</p><p><strong>Results: </strong>When the oxidation temperature was 35℃, oxidation time was 3 hours, and the oxidation pH was 2, a nearly linear relationship was observed between the degree of double aldehyde substitution and the amount of oxidizing agent when the molar ratio of NaIO_4 to Mongolian oak starch was less than 0.65. The optimal preparation conditions for the microcapsules were a degree of aldehyde substitution of 65%, a core-to-wall ratio of 1∶3.5, a wall material ratio of 1∶1, a solid-to-liquid ratio of 1∶40, encapsulation time of 4.0 hours, encapsulation temperature of 50℃, and an emulsifier dosage of 4 wt%. Under these conditions, the encapsulation efficiency of the microcapsules reached 90.856%.</p><p><strong>Conclusion: </strong>The microcapsules containing double aldehyde Mongolian oak starch wall material can selectively dissolve in intestinal environments and release tea polyphenols, achieving targeted release and demonstrating selective sustained-release effects.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 2","pages":"291-300"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between food intake and hyperuricemia in the elderly aged 18 years and above in China in 2018].","authors":"Mengru Dong, Yanli Wei, Yifei Ouyang, Huijun Wang, Zhihong Wang, Xiaorong Yuan, Xiaohui Dong, Jiguo Zhang","doi":"10.19813/j.cnki.weishengyanjiu.2025.02.009","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.02.009","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between food intake and hyperuricemia in the elderly aged 18 years and above in China.</p><p><strong>Methods: </strong>The present study used data from \"China Health and Nutrition Survey\" in 2018. Adults aged 18 years and above with complete questionnaires and anthropometric data were included in the analysis. Three consecutive 24 h dietary recalls method was used to collect dietary consumption data. Logistic regression model was applied to analyze the effect of food intake on hyperuricemia.</p><p><strong>Results: </strong>The prevalence of hyperuricemia in adults in fifteen provinces of China was 12.63% in 2018. Increased intake of rice(OR=1.419, 95%CI 1.143-1.761, P&lt;0.001), livestock meat(OR=1.332, 95%CI 1.082-1.641, P&lt;0.001), and poultry(OR=1.268, 95%CI 1.031-1.560, P&lt;0.001) in the daily diet would increase the risk of hyperuricemia; higher intake of fruit(OR=0.792, 95%CI 0.643-0.977, P&lt;0.001) was associated with a lower risk of hyperuricemia, and the risk of hyperuricemia was reduced in the 2nd tertile of dairy intake compared with non-intake group(OR=0.721, 95%CI 0.541-0.961, P&lt;0.001).</p><p><strong>Conclusion: </strong>For patients with hyperuricemia or people at risk of hyperuricemia, adherence to a diet of reduced intake of rice, livestock meat and poultry, increased intake of fruits, and moderate intake of dairy products can lower the serum uric acid level as well as the risk of developing hyperuricemia.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 2","pages":"229-236"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Influencing factors of delayed complementary food addition behavior among caregivers of infants aged 6 to 23 months in rural areas of Nanchong City: Based on the intergenerational perspective of caregivers].","authors":"Xinying Ji, Runxue Guo, Lu Liu, Liang Lyu, Weiwei Tang, Yuju Wu, Huan Zhou","doi":"10.19813/j.cnki.weishengyanjiu.2025.02.007","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.02.007","url":null,"abstract":"<p><strong>Objective: </strong>Clarify the status quo of delayed complementary food addition behavior among caregivers of infants aged 6-23 months in rural areas of Nanchong City, and explore its influencing factors from the perspective of different generations of caregivers.</p><p><strong>Methods: </strong>A multi-stage sampling method was used to enroll infants aged 6-23 months and their caregivers in four former national-level poor counties in Nanchong City, Sichuan Province in 2022. Through a self-designed structured questionnaire and computer-assisted face-to-face interview with a tablet computer, 800 pairs of infants and their caregivers were collected about their socio-demographic characteristics, caregivers&apos; complementary food addition time, complementary food feeding knowledge, complementary food feeding self-efficacy and social support. Based on the latest WHO recommendation that the best time to add complementary foods is at the age of 6 months, this study defined the delayed addition behavior as the caregiver starting to add complementary foods at the age of 7 months and later. Binary Logistic regression model and subgroup analysis were used to explore the influencing factors of delayed complementary food addition behavior of infant caregivers from different generational perspectives.</p><p><strong>Results: </strong>A total of 766 pairs of infants and their caregivers were included in this study, including 375(49.0%) male infants and 391(51.0%) female infants.246(32.1%) infants aged 6-11 months, 407(51.1%) infants aged 12-17 months, 113(14.8%) infants aged 18-23 months.201(26.2%) infants&apos; caregivers were grandparents and 565(73.8%) infants&apos; caregivers were parents. 243(31.7%) of the caregivers had primary school education or below, 268(35.0%) had junior high school education, and 255(33.3%) had senior high school education or above. A total of 222(28.98%) caregivers in remote rural areas of Sichuan Province had delayed complementary food addition behavior, and 80(39.8%) caregivers had delayed complementary food addition behavior among grandparents. 142(25.13%) caregivers had delayed complementary food addition behavior among the parents. Grandparents with low social support for complementary feeding(OR= 2.73, 95%CI 1.13-5.24) were more likely to delay complementary feeding. However, parental caregivers with low complementary feeding knowledge(OR=1.99, 95%CI 1.29-3.07) and low complementary feeding self-efficacy(OR=2.11, 95%CI 1.35-3.31) were more likely to delay complementary feeding.</p><p><strong>Conclusion: </strong>The influencing factors of delayed complementary feeding behavior of grandparents and parents in remote rural areas of Nanchong City are different. Social support for complementary food feeding is the influence factor of grandparents, and knowledge and self-efficacy of complementary food feeding is the influence factor of parents.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 2","pages":"214-221"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of four risk assessment methods to risk assessment of noise-induced hearing loss in metal mining enterprises].","authors":"Xin Wang, Ning Kang, Kai Liu, Kang Ning, Yiwen Dong, Meng Ye","doi":"10.19813/j.cnki.weishengyanjiu.2025.02.019","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.02.019","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare the application of four risk assessment methods in the noise-induced hearing loss risk assessment of metal mining enterprises.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Using typical sampling method, 27 metal mining enterprises were selected in Guangdong, Shandong and Liaoning Provinces. Enterprises basic information and noise exposure data of key positions were collected by using on-site hygiene investigation and noise detecting method. Occupational hazard risk index method, classification of occupational exposure to noise, guidelines for risk management of occupational noise hazard, the International Council on Mining and Mentals&apos;(ICMM) risk rating table method were used to analyze the risk of noise-induced hearing loss in metal mining enterprises.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The median individual noise exposure of metal mining positions was 83.0dB(A), and 36.5%(70/192) of the measured values exceeded 85 dB(A). The noise exposure levels of excavation workers(93.5 dB(A)), mill operators(90.4 dB(A)) and crusher operators(86.2 dB(A)) were higher relatively. Different mining method(underground and surface) had significant effects on noise exposure of workers(P&lt;0.05), and the noise exceeding standard rate of underground mining was higher(42.4%). According to the result of four risk assessment method, The overall occupational health risk level of noise-induced hearing loss was medium(weighted score 1.98) by ICMM risk rating table method, while the overall occupational health risk level of noise-induced hearing loss was low by occupational hazard risk index method, classification of occupational exposure to noise and guidelines for risk management of occupational noise hazard(weighted score 1.98, 1.73 and 1.86, respectively). The risk of excavation workers and mill operators were the highest, the risk of crusher operators was high, and the risk of air compressor operators, Screening operators, control workers, maintenance workers and pump operators were low or very low. The consistency of four risk assessment method was moderate(W=0.300, P&lt;0.001), The classification of occupational exposure to noise and the guidelines for risk management of occupational noise hazard showed that these two risk assessment method had strong consistencies(Kappa=0.789, P&lt;0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The overall occupational health risk level of noise-induced hearing loss in metal mining enterprises in three provinces was low, and the highest risk positions were excavation workers and mill operators in 2019-2021. The classification of occupational exposure to noise and the guidelines for risk management of occupational noise hazard might overestimate the noise hazard risk when workers were equipped personal protection well. ICMM risk rating table method can distinguish the risk levels of different positions effectively and identify the high-risk hearing loss position as early warning. Occupational hazard risk i","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 2","pages":"301-309"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}