卫生研究最新文献

{"title":"[Geographical distribution characteristics of nutrition knowledge among Chinese school-aged children in 2023 to 2024].","authors":"Yujie Qiu, Caicui Ding, Fan Yuan, Tanchun Yu, Li He, Ailing Liu","doi":"10.19813/j.cnki.weishengyanjiu.2026.01.004","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.01.004","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the geographical distribution characteristics of the nutrition knowledge(NK) level among school-aged children in China.</p><p><strong>Methods: </strong>Data were from the China Nutrition Knowledge Survey among school-aged children from 2023 to 2024. The survey was conducted using a multi-stage stratified cluster random sampling method at 195 survey points, covering all grades from primary to senior high school, with data from 90 240 students in senior primary, junior and senior high school grades ultimately analyzed. After applying complex weighting to the sample, the population&apos;s NK level and its geographical disparities were described. The NK scores were described using mean±standard error, and the NK awareness rate was described using rates and 95%CI. Differences in scores across regions were tested using a complex sampling design-based one-way linear regression model, and comparisons of the awareness rates were performed using a design-based Rao-Scott χ~2 test.</p><p><strong>Results: </strong>Urban children had higher scores(70.4±0.5) and NK awareness rates(n=31 750, 44.0%) than rural children(score: 66.5±0.9, awareness rate 32.4%(n=5667)). The eastern region(71.5±0.8, 47.3%(n=16 823)) also outperformed the central(67.4±0.8, 36.2%(n=10 200)) and western(67.7±0.8, 34.0%(n=10 404)) regions. Among all areas, North China recorded the highest NK level(72.3±0.7, 49.8%(n=5882)), while Northwest region had the lowest(65.1±0.8, 27.0%(n=2784)). All these reigonal differences were statistically significant(P&lt;0.01). Regarding specific knowledge points, the correct rate for identifying a balanced breakfast was the lowest among primary school students across all regions(urban 14.6%, rural 14.5%; eastern 14.6%, central 11.8%, western 17.2%). For junior high school students, knowledge about the expiration date and food safety had the lowest correct rate(urban 18.0%, rural 18.9%; eastern 17.6%, central 17.0%, western 21.0%). For senior high school students, knowledge about the recommended intake of cooking oil had the lowest correct rate in the western region(19.4%), while in other regions, knowledge about expiration date and food safety remained the weakest.</p><p><strong>Conclusion: </strong>Significant geographical disparities were observed in the NK levels of Chinese school-aged children. Urban children, as well as those from the eastern and northern regions, demonstrated significantly higher NK levels than their rural, central/western, and northwestern counterparts.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"55 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Assessment of the effectiveness of recombinant human lactoferrin using an intestinal barrier and Tohoku hospital pediatrics-1 co-culture model].","authors":"Xiayu Zhao, Qin Zhuo, Zhuo Yang, Jingbo Wang, Wen Qin, Liyuan Wang","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.015","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.015","url":null,"abstract":"<p><strong>Objective: </strong>Developing a microfluidic organ chip-based in vitro gut immune co-culture model to assess the anti-inflammatory properties and barrier protection effects of recombinant human lactoferrin(rHLF) in this highly biomimetic system.</p><p><strong>Methods: </strong>An inflammatory model was established by co-culturing a human-derived intestinal organoid barrier, constructed using organ chips, with the human monocyte line Tohoku hospital pediatrics-1(THP-1). The model was stimulated with lipopolysaccharide(LPS) to activate intestinal epithelial cells and THP-1-induced macrophages. The experiment included a model control group, an LPS group, 200 and 1000 μg/mL rHLF group. High-content imaging was employed to assess cell apoptosis, while a cell resistance meter measured transmembrane resistance(TEER). Enzyme-linked immunosorbent assay(ELISA) was utilized to evaluate fluorescein apparent permeability(Papp), and RT-qPCR was used to quantify the mRNA expression of inflammatory cytokines tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), IL-6, IL-8, chemokines(CCL2), oxidative stress-related enzymes nitric oxide synthase 2(NOS2), prostaglandin-endoperoxide synthase 2(PTGS2), and barrier-related cell junction proteins tight junction protein 1(TJP1).</p><p><strong>Results: </strong>In the co-culture system of THP-1 and small intestine organoids, compared with the LPS group, the apoptosis signal of the rHLF group was significantly weakened, the barrier TEER value was significantly increased and the Papp value was significantly reduced(P&lt;0.05). The expression of IL-1β and IL-8, chemokine CCL2, and oxidative stress-related enzymes NOS2 and PTGS2 was significantly reduced(P&lt;0.05).</p><p><strong>Conclusion: </strong>The rHLF may inhibit the expression of IL-1β, IL-8 and CCL2, directly reducing intestinal mucosal inflammation and protecting the intestinal mucosal barrier function. It may also downregulate the oxidative stress pathway enzyme PTGS2 and other mechanisms, providing protective effects against LPS-induced in vitro damage to the intestinal epithelial barrier.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"978-1000"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between serum vitamin D levels and common comorbidities of frailty among community-dwelling older people under varying inflammatory conditions].","authors":"Cheng Li, Yuqian Li, Ting Zhang, Hua Wu, Huijuan Jia, Hua Wu, Pengkun Song, Jian Zhang","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.006","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.006","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between serum vitamin D levels and common frailty-related comorbidities, including sarcopenia and dysphagia, in community-dwelling older people, and to analyze the influence of varying inflammatory conditions.</p><p><strong>Methods: </strong>From August to December 2020, 894 community-dwelling older people aged ≥65 years were recruited from Guangdong, Jiangsu, and Inner Mongolia. Data were collected through questionnaire surveys, physical measurements, sarcopenia assessment(grip strength, gait speed, body composition), dysphagia evaluation, and blood biomarker testing(vitamin D, high-sensitivity C-reactive protein(hsCRP)). Multivariate Logistic regression models were employed to examine the associations between vitamin D and frailty-related comorbidities, as well as the interaction effects of inflammatory levels.</p><p><strong>Results: </strong>A total of 884 older people completed the survey. The prevalence of sarcopenia was 14.48%, and the prevalence of dysphagia(including suspected dysphagia) was 34.84%. The median levels of 25-(OH)D_2(0.28 ng/mL) and 25-(OH)D_3(24.69 ng/mL) in the dysphagia group were significantly lower than those in the non-dysphagia group(0.45 ng/mL and 27.18 ng/mL, respectively; P&lt;0.01). A significant interaction was observed between 25-(OH)D_3 and hsCRP in relation to dysphagia(P&lt;0.05). Subgroup analysis revealed that in older people with hsCRP&lt;3 mg/L, 25-(OH)D_3 levels were negatively associated with suspected dysphagia(OR=0.98, 95%CI 0.96-0.99, P&lt;0.05), whereas no significant association was found in those with hsCRP&gt;3 mg/L.</p><p><strong>Conclusion: </strong>Serum vitamin D levels in community-dwelling elderly individuals were significantly associated with swallowing function, and this association was influenced by inflammatory status: in the population with low inflammatory levels, serum vitamin D levels were negatively associated with the risk of dysphagia, while there was no significant association in the population with high inflammatory levels.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"915-922"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Anti-exercise fatigue and mechanism of Keap1/Nrf2 pathway in liver of aqueous extract of aronia melanocarpa].","authors":"Peifei Gu, Jianhua Diao, Huijia Zhu, Xiuyan Wei, Chang Li, Peng Guo","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.017","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.017","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the anti-fatigue effect of aqueous extract of aronia melanocarpa on exhausted running mice and its mechanism.</p><p><strong>Methods: </strong>A mouse model of exhaustive running was used to observe the effects of different doses of aqueous extract of aronia melanocarpa on the time of exhaustive running, and the biochemical indicators such as lactic acid, urea nitrogen and liver/muscle glycogen in the serum of mice were measured to evaluate the anti-exercise-induced fatigue effect in mice. The antioxidant effect of the aqueous extract of aronia melanocarpa was investigated by measuring MDA and SOD. Western blot was used to detect the expression levels of key proteins in the Keap1/Nrf2 antioxidant signaling pathway.</p><p><strong>Results: </strong>The aqueous extract of aronia melanocarpa could increase the content of liver glycogen and SOD, and reduce the levels of lactic acid, urea nitrogen and MDA by prolonging the exhaustion running time of mice. The expression levels of Keap1 protein in liver tissues induced by exhaustive running were down-regulated, and the expression levels of Nrf2 and HO-1 proteins were up-regulated.</p><p><strong>Conclusion: </strong>The aqueous extract of aronia melanocarpa has anti-fatigue effect, which may be played by activating the Keap1/Nrf2 antioxidant pathway.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"990-994"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between adaptation and anxiety/depression among medical freshmen in Wuhu in 2022: The mediating role of negative emotion regulation self-efficacy].","authors":"Yujing Tao, Haoqi Li, Yin Feng, Jie Liu, Chenjie Ma, Yuelong Jin, Liying Wen, Weiwei Chang","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.012","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.012","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between college adaptation, emotion regulation self-efficacy, and anxiety/depression among medical freshmen, and to analyze the mediating role of emotion regulation self-efficacy in the association between adaptation and mental health, providing evidence for targeted psychological interventions.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in November 2022 using a stratified cluster random sampling, involving 1866 medical freshmen from two colleges in Wuhu City, Anhui Province. The student adaptation to College Questionnaire, Self-Regulation of Emotion Self-Efficacy Scale, Generalized Anxiety Disorder-2, and Patient Health Questionnaire-2 were used to assess adaptation, emotion regulation self-efficacy, anxiety, and depression, respectively. Pearson correlations analysis was conducted to examine the associations between medical freshmen&apos;s college adaptation, emotion regulation self-efficacy, and anxiety/depression. Subsequently, bias-corrected Bootstrap mediation analysis(5000 resamples) was employed to test the mediating role of emotion regulation self-efficacy in the relationship between college adaptation and anxiety/depression.</p><p><strong>Results: </strong>The average age of the 1866 surveyed medical freshmen was(18.78±1.23) years old, with 727 males(39.0%) and 1139 females(61.0%). The prevalence rates of anxiety and depression were 11.68%(218/1866) and 12.33%(230/1866), respectively. The overall adaptation score of medical freshmen was 3.46±0.51, with the lowest score observed in learning adaptation(3.21±0.67). College adaptation demonstrated significantly negative correlations with anxiety/depression(r=-0.482 and-0.505, P&lt;0.01), and positive associations with expressive positive emotion self-efficacy and regulatory negative emotion self-efficacy(r=0.412, r=0.467, both P&lt;0.01). Positive emotion regulation efficacy and negative emotion management efficacy demonstrated significant negative correlations with anxiety scores(r=-0.205, r=-0.358) and depression scores(r=-0.246, r=-0.345), respectively(P&lt;0.01). Mediation analysis demonstrated that regulatory negative emotion self-efficacy partially mediated the relationship between adaptation and anxiety(indirect effect β=-0.083, SE=0.013, 95%CI-0.109 to-0.059; proportion mediated: 16%) and depression(β=-0.068, SE=0.013, 95%CI-0.093 to-0.043; proportion mediated: 13%).</p><p><strong>Conclusion: </strong>Medical freshmen&apos;s adaptation and emotion regulation self-efficacy are closely related to anxiety and depressive emotions. Adaptation can not only directly and negatively predict the levels of anxiety and depression, but also indirectly reduce psychological risks by enhancing the self-efficacy in managing negative emotions.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"958-964"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Influencing factors of cognitive frailty in urban community elderly based on Lasso regression].","authors":"Shanshan Jia, Donghai Wei, Biao Zheng, Lingyun Shi, Liping Kang, Xiaona Zhang, Qingqing Man, Jian Zhang","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.005","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.005","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the influencing factors of cognitive frailty in urban community elderly.</p><p><strong>Methods: </strong>Using convenience sampling, we recruited 1086 elderly aged ≥65 years from two study sites(Dongying City, Shandong Province and Jiangbei District, Chongqing Municipality) between July 2022 and June 2023. Data collection included general demographic characteristics and dietary assessment using food frequency questionnaires. The assessment of cognitive frailty was conducted using the Fried frailty phenotype criteria combined with the Chinese version of the mini-mental state examination. Physical measurements and blood sample collection were performed. Variable selection was performed using Lasso regression, followed by Logistic regression analysis to identify factors associated with cognitive frailty among urban community elderly.</p><p><strong>Results: </strong>Among the 1086 elderly, a total of 270 cases(24.9%) had cognitive frailty. Significant differences were observed between the two groups regarding pension income and number of chronic conditions(P&lt;0.05). The cognitive frailty rates decreased with the pension income and the number of chronic, the trend were statistically significant(P&lt;0.05). Compared to non-cognitively frail elderly, those with cognitive frailty had significantly lower weekly intake frequencies of grains &amp; tubers, fish/shellfish, eggs, fresh vegetables, and fruits(P&lt;0.05), diastolic blood pressure, 6-meter walking speed, triglycerides, interleukin-6, albumin, vitamin B_(12), the abnormal rates of calf circumference and handgrip strength were significantly higher(P&lt;0.05). Based on Lasso regression, 14 variables were selected: level of education, living arrangement, pension income, calf circumference, intake frequency of grains/tubers, fish/shellfish, dairy products, vegetables, and fruits, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, and vitamin B_(12) levels. Multivariable Logistic regression analysis result showed that: adjusted for age, sex and level of education, revealed the following protective factors against cognitive frailty: a monthly pension of 4001-6000 RMB/month(OR=0.356, 95%CI 0.218-0.583), &gt;6000 RMB/month(OR=0.542, 95%CI 0.302-0.971), fish/shellfish consumption(OR=0.815, 95%CI 0.682-0.973) and fruit intake(OR=0.955, 95%CI 0.914-0.998). The risk factors for cognitive frailty were co-residence(OR=2.038, 95%CI 1.065-3.903) and abnormal calf circumference(OR=2.196, 95%CI 1.591-3.031).</p><p><strong>Conclusion: </strong>The prevalence of cognitive frailty among urban community elderly is high with multifactorial determinants.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"908-914"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Relationship between maternal serum glucose levels and human milk glucose concentrations].","authors":"Yu Zhou, Shuxia Wang, Qi Chen, Jie Wang, Yifan Duan, Shan Jiang, Zhenyu Yang","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.008","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.008","url":null,"abstract":"<p><strong>Objective: </strong>To study the relationship between glucose levels in serum and glucose levels in maternal milk in healthy lactating women, and to discuss the factors influencing maternal milk glucose concentrations.</p><p><strong>Methods: </strong>The samples and data were from the database for human milk composition in China between 2011 and 2013. A total of 184 lactating women with complete serum and breast milk glucose concentrations were included from 11 provinces across China. The human milk glucose was analyzed using high-performance anion exchange chromatography, and the serum glucose was analyzed with an automated biochemical analyzer. Using a general linear model, the relationship between maternal blood glucose levels and breast milk glucose concentrations was analyzed, along with the factors influencing breast milk glucose concentrations.</p><p><strong>Results: </strong>The average age of the study participants is(27.4±4.3) years, with 18(9.8%) having hypoglycemia, 164(89.1%) having normal blood glucose levels, and 2(1.1%) having hyperglycemia. The average maternal blood glucose level was(82.08±10.21) mg/dL. There was no significant difference in breast milk glucose concentrations between the hypoglycemia and normal blood glucose groups((26.90±8.84) mg/dL vs(24.76±10.11) mg/dL, P=0.39). There was no significant correlation observed between maternal blood glucose and breast milk glucose concentrations(r=-0.089, P=0.23, n=184). After stratifying by blood glucose levels and adjusting for factors such as lactation stage, parity, and outdoor activity time, no significant association was found as well(hypoglycemia: β=-0.341, P=0.21; normal blood glucose: β=-0.073, P=0.54). Multivariate analysis showed that the glucose concentration in late mature milk was significantly higher than that in early mature milk(29.08 mg/dL vs 23.63 mg/dL, P=0.02). Multiparous mothers had higher glucose concentrations in human milk compared to primiparous mothers(28.34 mg/dL vs 24.37 mg/dL, P&lt;0.01), and there was a positive correlation between the duration of outdoor activities in the past 24 hours and glucose concentration in human milk(β=0.963, P&lt;0.01).</p><p><strong>Conclusion: </strong>Milk glucose concentrations was not significantly associated with maternal serum glucose concentrations in healthy lactating women. Lactation stage and parity were related to milk glucose concentrations, and outdoor activity time showed a positive correlation.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"930-936"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Scientific consensus on postbiotics].","authors":"","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.001","DOIUrl":"10.19813/j.cnki.weishengyanjiu.2025.06.001","url":null,"abstract":"<p><p>The term \"postbiotics\" has been increasingly used in scientific literature and commercial products, yet a standardized definition remains elusive. In 2021, the International Scientific Association for Probiotics and Prebiotics issued a consensus statement on the definition of postbiotics, which has achieved broad international recognition and application, but some scholarly debate remained. This article re-evaluated the postbiotic concept through scientific, commercial, and regulatory lenses, proposing the definition as \"a preparation of inanimate microorganisms and/or their components that confers a scientifically substantiated human health benefit. \" Meanwhile, the conceptual framework underpinning this definition was systematically elaborated. Furthermore, we consolidated criteria for postbiotics selection and evaluation method ologies. We critically synthesized clinical trial evidence demonstrating efficacy across multiple health domains, including: gastrointestinal disorders, constipation, immune modulation and upper respiratory infections, metabolic diseases, oral and skin health, etc. Then, mechanistic insights were analyzed through three key pathways: modulation of gut microbiota composition/function, enhancement of intestinal barrier integrity, regulation of immune system responses. Collectively, this work provided an evidence-based foundation to advance postbiotic research, industrial development, and standardization efforts.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"879-890"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of dietary diversity and physical activity with frailty and prefrailty among community-dwelling older adults in urban].","authors":"Xiaona Zhang, Shanshan Jia, Jing Huang, Zhanghui Du, Yan Wang, Dongying Li, Dandan Yang, Mingkuan Lyu, Qingqing Man, Weiguo Wang","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.003","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.003","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between dietary diversity, physical activity, and frailty/prefrailty among community-dwelling older adults.</p><p><strong>Methods: </strong>From August 2022 to June 2023, 943 individuals aged 65 years and older living in community were recruited at Shengli Shengdong Hospital in Dongying, Shandong Province. Face-to-face questionnaires were used to collect information on main food intake and physical activity. Frailty and prefrailty were assessed using the Fried frailty phenotype. Dietary diversity was evaluated using the dietary diversity score(DDS). Group comparisons were performed using Wilcoxon, Chi-square, or ANOVA tests, while trend tests were conducted using Cochran-Armitage or Jonckheere-Terpstra tests. Partial proportional Logistic regression models were used to analyze the relationships between dietary diversity, main food intake, physical activity, and frailty/prefrailty.</p><p><strong>Results: </strong>Compared to non-frailty group, a significantly decrease in DDS, frequencies of fresh vegetables, soybeans and nuts intakes, and frequencies and durations of walking, exercise, and housework was observed in prefrailty group and frailty group. After adjusting for age, sex, education level, marital status, smoking, alcohol consumption, and dietary supplement use, an increased number of chronic diseases was a risk factor for frailty(OR=1.22, 95%CI 1.21-1.32), while increased DDS(OR=0.90, 95%CI 0.85-0.96), higher frequencies of weekly walking(OR=0.89, 95%CI 0.87-0.92), housework(OR=0.97, 95%CI 0.95-0.99), and higher duration of walking(≥60 min/d)(OR=0.58, 95%CI 0.42-0.81) were protective factors against frailty. There was an interaction between dietary diversity and physical activity on frailty.</p><p><strong>Conclusion: </strong>Dietary diversity and physical activity are associated with frailty and prefrailty among the elderly in the community. Increasing dietary diversity, the frequency and duration of weekly walks, and the frequency of housework can reduce the risk of frailty among the elderly.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"893-907"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of dietary patterns and enterotypes on frailty-related metabolic indicators in elderly diabetics].","authors":"Yuqian Li, Hua Wu, Huijuan Jia, Cheng Li, Shuang Song, Shanshan Jia, Pengkun Song, Hua Wu, Jian Zhang","doi":"10.19813/j.cnki.weishengyanjiu.2025.06.007","DOIUrl":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2025.06.007","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effects of dietary patterns and enterotypes on frailty-related metabolic indicators, specifically glycated hemoglobin(HbA1c), in elderly diabetic patients.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted involving 72 diabetic patients aged 65 years and older from Liyang City, Jiangsu Province, and Wuyuan County, Bayannur City, Inner Mongolia Autonomous Region. Data collected included basic information, dietary intake, HbA1c levels, and fecal samples analyzed via 16S rDNA sequencing. Logistic regression models were used to analyze the impact of dietary patterns and enterotypes on elevated HbA1c. Additive models were employed to assess interaction effects.</p><p><strong>Results: </strong>After adjusting for gender, age, residence location, body mass index, and blood glucose management method, Logistic regression analysis revealed that: A dietary pattern characterized by low intake of soybeans and soy products, fresh vegetables, red meat, and poultry was a risk factor for elevated HbA1c in the participants(OR=3.4, 95%CI 1.1-10.6, P&lt;0.05). The Prevotella-dominant enterotype was a protective factor against elevated HbA1c(OR=0.2, 95%CI 0.1-0.8, P&lt;0.05). Interaction analysis of risk factors for elevated HbA1c showed no additive interaction between dietary pattern and enterotype.</p><p><strong>Conclusion: </strong>A dietary pattern featuring low intake of soybeans and soy products, fresh vegetables, red meat, and poultry is a risk factor for elevated HbA1c in elderly diabetics, while the Prevotella-dominant enterotype is a protective factor against elevated HbA1c.</p>","PeriodicalId":57744,"journal":{"name":"卫生研究","volume":"54 6","pages":"923-944"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}