Photoacoustics最新文献

{"title":"Multimodal PA/US imaging and radiomics for the prediction of HER2-zero, -low, and -positive breast cancers: A novel approach for targeted therapy selection","authors":"Zhibin Huang ,&nbsp;Guoqiu Li ,&nbsp;Mengyun Wang ,&nbsp;Sijie Mo,&nbsp;Huaiyu Wu,&nbsp;Hongtian Tian,&nbsp;Shuzhen Tang,&nbsp;Jinfeng Xu,&nbsp;Fajin Dong","doi":"10.1016/j.pacs.2025.100764","DOIUrl":"10.1016/j.pacs.2025.100764","url":null,"abstract":"<div><h3>Purpose</h3><div>This study evaluates the efficacy of photoacoustic/ultrasound (PA/US) imaging-based radiomics for distinguishing HER2-zero, HER2-low, and HER2-positive breast cancer (BC), aiming to enhance targeted therapy selection.</div></div><div><h3>Methods</h3><div>We analyzed 346 pathologically confirmed BC patients who underwent multimodal PA/US imaging at Shenzhen People’s Hospital from January 2022 to January 2025. HER2 status was determined pathologically and classified into three levels. Radiologists assessed conventional US features and manually segmented tumors on PA-images for radiomics feature extraction. Using the Least Absolute Shrinkage and Selection Operator analysis, we developed radiomics models for differentiating between HER2-zero versus HER2-low/positive cancers (Task 1), and HER2-low versus positive cancers (Task 2), and HER2-zero versus low cancers (Task 3). Patients were randomly divided into training sets and testing sets. Multivariate logistic regression was used to integrate radiomics, clinical-pathological, and US features into nomograms.</div></div><div><h3>Results</h3><div>In testing set, radiomics features demonstrated an AUC of 0.846 with sensitivity of 79.3 % and specificity of 72.7 % for Task 1, and an AUC of 0.801 with sensitivity of 64.0 % and specificity of 82.8 % for Task 2, and an AUC of 0.767 with sensitivity of 80.7 % and specificity of 72.7 % for Task 3. For Task 1, 2 and 3, nomograms including PA imaging radiomics features combined with clinical-pathological features achieved AUCs of 0.848, 0.881 and 0.780, respectively.</div></div><div><h3>Conclusion</h3><div>PA radiomics features effectively differentiate between HER2-zero and HER2 low/positive, and between HER2-low and HER2-positive BC, offering potential utility in guiding targeted therapy decisions.</div></div><div><h3>Summary</h3><div>This study demonstrates the potential of PA imaging-based radiomics for accurately classifying HER2 expression statuses in BC, enhancing the selection process for targeted therapies. By integrating multi-modal imaging and pathology data, the developed radiomics models show robust performance, promising a non-invasive diagnostic supplementary for clinical application where traditional methods are limited.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100764"},"PeriodicalIF":6.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional optical path extended gourd-type photoacoustic cell for highly sensitive trace acetylene sensing","authors":"Chuanwen Qian ,&nbsp;Wenjun Ni ,&nbsp;Chunyong Yang ,&nbsp;Zhongke Zhao ,&nbsp;Likang Zhang ,&nbsp;Sixiang Ran ,&nbsp;Chenyu Wang ,&nbsp;Ping Lu ,&nbsp;Perry Ping Shum","doi":"10.1016/j.pacs.2025.100762","DOIUrl":"10.1016/j.pacs.2025.100762","url":null,"abstract":"<div><div>A novel gourd-type photoacoustic cell (GTPAC) has been developed, featuring a highly reflective, polished gold film-coated inner wall that minimizes optical loss and maximizes light utilization efficiency. GTPAC integrates two coupled spherical chambers with a radius ratio 2:3, which is close to the golden ratio. Its unique Gaussian curvature distribution enables multi-directional, disordered light beam reflection without complex optical alignment. It creates a non-periodic three-dimensional (3D) optical trajectory, significantly enhancing light-molecule interactions. GTPAC achieves an exceptionally high sensitivity of up to 3.36 μV/ppm using a distributed feedback butterfly laser with central wavelength of 1532 nm (±1.5 nm) to detect acetylene gas. When the integration time is extended to 100 s, the minimum detection limit is as low as 0.59 ppb. Moreover, its flexible design and broad spectral compatibility enable significant potential for extension to other gases, such as methane and nitrogen oxides, offering new prospects for ultra-sensitive trace gas detection.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100762"},"PeriodicalIF":6.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An acoustic-optic confocal probe based photoacoustic and ultrasonic tracheal endoscopy for characterizing phantom and model of chronic obstructive pulmonary disease","authors":"Xiaowei Chen ,&nbsp;Xue Wen ,&nbsp;Bingyan Fang ,&nbsp;Zhixiong Lei ,&nbsp;Jiarui Chen ,&nbsp;Lvming Zeng ,&nbsp;Kedi Xiong ,&nbsp;Weizhan Luo ,&nbsp;Lan Zhang ,&nbsp;Hongbo Fu ,&nbsp;Shiyue Li ,&nbsp;Jian Zhang","doi":"10.1016/j.pacs.2025.100760","DOIUrl":"10.1016/j.pacs.2025.100760","url":null,"abstract":"<div><div>Integrated photoacoustic endoscopy and endoscopic ultrasound (PAE/EUS) are recognized as an effective method for detecting intestinal and intravascular diseases. Changes in the morphology and composition of the trachea are significant hallmarks of respiratory diseases. In this study, an acoustic-optic confocal probe was developed and integrated at the tip of a 2.1 mm diameter catheter to perform simultaneous PAE/EUS imaging. Phantom experimental results demonstrated that the catheter achieved a high lateral resolution of 11 µm, with an imaging depth of 12 mm, using an excitation energy of 1.5 μJ. Trachea from healthy and chronic obstructive pulmonary disease (COPD) rabbit models and <em>in vivo</em> were imaged by the PAE/EUS system. The results demonstrated that photoacoustic imaging could identify increases in the diameter and density of the tracheal microvessels, while ultrasound imaging provided detailed views of the tracheal submucosa. These findings underscore the potential of PAE/EUS in the diagnosis of COPD.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100760"},"PeriodicalIF":6.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive light-induced thermoelastic spectroscopy based on transmitted light amplification","authors":"Zhenfeng Gong ,&nbsp;Ruoran Kan ,&nbsp;Mingzhe Li ,&nbsp;Mi Zhou ,&nbsp;Guojie Wu ,&nbsp;Xiang Chen","doi":"10.1016/j.pacs.2025.100759","DOIUrl":"10.1016/j.pacs.2025.100759","url":null,"abstract":"<div><div>This paper investigates the light-induced thermoelastic spectroscopy (LITES) based on transmitted light amplification to realize high-precision gas detection. The modulated laser beam passes through a multi-pass cell and is then coupled to an optical amplifier. The multi-pass cell reflects the laser beam 100 times, has an optical length of 16 m, and its transmitted light intensity is 1.67 mW. A narrowband fiber optical filter with a bandwidth of 0.8 nm is utilized to suppress optical noise. Based on the transmitted light amplification, the signal-to-noise ratio (SNR) is improved by a factor of 3.6. To investigate the enhancement of second harmonic (2 <em>f</em>) signals under weak light intensities, a fiber optical attenuator is adopted to attenuate the transmitted light intensity. While the transmitted light intensity is attenuated to 0.048 mW, a high SNR of 1823 and a minimum detection limit (MDL) of 0.110 ppm can be obtained. Hence, LITES based on transmitted light amplification enables high-precision measurements while the light intensity is only at the scale of μW. This approach facilitates a significant increase in the number of beam reflections as well as the optical length of the multi-pass cell and resonant cavity for LITES sensors.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100759"},"PeriodicalIF":6.8,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sparse scanning encoding and neural network decoding for compressed photoacoustic microscopy","authors":"Junjie She ,&nbsp;Qican Zhang ,&nbsp;Yajun Wang ,&nbsp;Hongying Hu ,&nbsp;Meng You ,&nbsp;Junfei Shen","doi":"10.1016/j.pacs.2025.100757","DOIUrl":"10.1016/j.pacs.2025.100757","url":null,"abstract":"<div><div>Photoacoustic microscopy (PAM) offers high-resolution, non-invasive, and label-free imaging, making it invaluable for biomedical research. However, slow data acquisition and high sampling requirements remain key challenges that limit its broader applicability and scalability. We propose an Information-Efficient Photoacoustic Microscopy (IE-PAM) that jointly integrates sparse scanning encoding with neural network decoding to achieve high-quality reconstruction from extremely limited measurements. Specifically, IE-PAM employs a sparse-scanning acquisition scheme guided by random binary masks and reconstructs high-fidelity images using AFDU-Net, a custom-designed neural decoder trained on fully sampled ground truth data. Our system can faithfully recover detailed anatomical structures from as little as 1.5 % of the full sampling rate, corresponding to more than a 66-fold increase in acquisition efficiency. In in-vivo experiments on mouse ear vasculature, IE-PAM outperforms both traditional and learning-based baselines in fine vascular fidelity, artifact suppression, and robustness across varying sampling rates. By minimizing information redundancy at the acquisition stage and enabling accurate reconstruction from minimal data, IE-PAM provides a foundation for efficient, fast and scalable photoacoustic imaging in both preclinical and research applications.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100757"},"PeriodicalIF":6.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing photoacoustic trace gas detection via a CNN–transformer denoising framework","authors":"Chen Zhang ,&nbsp;Yan Gao ,&nbsp;Ruyue Cui ,&nbsp;Hanxi Zhang ,&nbsp;Jinhua Tian ,&nbsp;Yujie Tang ,&nbsp;Lei Yang ,&nbsp;Chaofan Feng ,&nbsp;Pietro Patimisco ,&nbsp;Angelo Sampaolo ,&nbsp;Vincenzo Spagnolo ,&nbsp;Xukun Yin ,&nbsp;Lei Dong ,&nbsp;Hongpeng Wu","doi":"10.1016/j.pacs.2025.100758","DOIUrl":"10.1016/j.pacs.2025.100758","url":null,"abstract":"<div><div>We present a novel approach for gas concentration measurement using a differential resonant photoacoustic cell combined with a deep learning-based signal denoising model. This method addresses the persistent challenge of noise interference in 2 <em>f</em> signals at low gas concentrations, where conventional processing methods struggle to maintain signal fidelity. To resolve this, we propose a deep learning model that integrates 1D Convolutional Neural Networks (1D CNNs) for local feature extraction and Transformer networks for capturing global dependencies. The model was trained using synthetic signals with added noise to simulate real-world conditions, ensuring robustness and adaptability. Applied to experimental 2 <em>f</em> signals, the model demonstrated excellent noise suppression capabilities, enhancing the signal-to-noise ratio (SNR) of 500 ppb acetylene signals by a factor of approximately 70. Furthermore, the determination coefficient (R²) improved, reflecting better accuracy and linearity in signal reconstruction. These results underscore the model's potential for improving detection sensitivity and reliability in trace gas measurements, marking a significant advancement in spectroscopic signal processing for gas detection.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100758"},"PeriodicalIF":6.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magneto-photoacoustic coupling: A pathway to optical-resolution electrical conductivity imaging","authors":"Songqing Xie ,&nbsp;Zhuojun Xie ,&nbsp;Shuai Na","doi":"10.1016/j.pacs.2025.100755","DOIUrl":"10.1016/j.pacs.2025.100755","url":null,"abstract":"<div><div>Electrical conductivity is a critical biomarker for cellular activity and a fundamental parameter in material science. However, achieving label-free, contact-free conductivity measurements with optical-scale resolution remains a challenge. Here, we introduce a magneto-photoacoustic coupling effect that enables conductivity mapping through photoacoustic excitation in the presence of a static magnetic field. The governing equation for this phenomenon is derived, demonstrating a linear relationship between the induced photoacoustic pressure and the product of the local magnetic flux density squared and electrical conductivity. This theoretical framework is further validated using numerical simulation, which showcases the method’s capability for optical-resolution conductivity imaging. The proposed approach unlocks new opportunities for applications ranging from real-time tracking of neuronal ion channel dynamics to nanoscale defect characterization in metallic and semiconductor materials.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100755"},"PeriodicalIF":6.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optoacoustic imaging in lower extremity revascularization: A novel technique to assess perioperative muscle perfusion","authors":"Tim Wittig ,&nbsp;Birte Winther ,&nbsp;Charlene Reichl ,&nbsp;Andrej Schmidt ,&nbsp;Dierk Scheinert ,&nbsp;Sabine Steiner","doi":"10.1016/j.pacs.2025.100756","DOIUrl":"10.1016/j.pacs.2025.100756","url":null,"abstract":"<div><h3>Objectives</h3><div>This proof-of-concept study aimed to assess the feasibility of Multispectral Optoacoustic Tomography (MSOT) in evaluating changes in oxygenated hemoglobin (HbO2) levels in muscles of the lower limb before and after lower extremity revascularization (LER).</div></div><div><h3>Methods</h3><div>In 26 patients, HbO2 levels were assessed before and after LER, with follow-up assessing symptom control and patency for up to six months.</div></div><div><h3>Results</h3><div>A significant difference in HbO2 levels was observed between pre- and post-LER in the muscles of the lower limb. In 10 patients, HbO2 levels did not increase following LER, and at the 6-month follow-up, 2 of these patients required target lesion revascularization (TLR) due to restenosis of ≥ 50 % stenosis. In contrast, 16 patients demonstrated increased HbO2 levels post-LER, with no patients requiring TLR at 6-months.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the potential of MSOT to detect changes in tissue perfusion following LER, highlighting its promise as a novel imaging modality for guiding treatment strategies.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100756"},"PeriodicalIF":6.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-optical in vivo photoacoustic tomography by adaptive multilayer acoustic backpropagation","authors":"Taeil Yoon ,&nbsp;Hakseok Ko ,&nbsp;Jeongmyo Im ,&nbsp;Euiheon Chung ,&nbsp;Wonshik Choi ,&nbsp;Byeongha Lee","doi":"10.1016/j.pacs.2025.100753","DOIUrl":"10.1016/j.pacs.2025.100753","url":null,"abstract":"<div><div>Photoacoustic tomography (PAT) combines high optical contrast with deep acoustic penetration, making it valuable for biomedical imaging. However, all-optical systems often face challenges in measuring the acoustic wave-induced displacements on rough and dynamic tissues surfaces. We present an all-optical PAT system enabling fast and high-resolution volumetric imaging <em>in vivo</em>. By integrating holographic microscopy with a soft cover layer and coherent averaging, the system detects ultrasound-induced surface displacements over a 10 × 10 mm² area with 0.5 nm sensitivity in 1 s. A novel backpropagation algorithm reconstructs a depth-selective pressure image from two consecutive displacement maps. The coherent summation of these depth-selective pressure images enables the reconstruction of a 3D acoustic pressure image. Using adaptive multilayer backpropagation, we achieve imaging depths of up to 5 mm, with lateral and axial resolutions of 158 µm and 92 µm, respectively, demonstrated through <em>in vivo</em> imaging of mouse vasculature and chicken embryo vessels.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100753"},"PeriodicalIF":6.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conductance-photoacoustic spectroscopy for fast and concurrent sensing of hydrogen and hydrocarbons","authors":"Ruobin Zhuang ,&nbsp;Jianfeng He ,&nbsp;Haoyang Lin ,&nbsp;Huijian Luo ,&nbsp;Leqing Lin ,&nbsp;Lihao Wang ,&nbsp;Bin Liu ,&nbsp;Wenguo Zhu ,&nbsp;Yongchun Zhong ,&nbsp;Jianhui Yu ,&nbsp;Markus Sigrist ,&nbsp;Huadan Zheng","doi":"10.1016/j.pacs.2025.100752","DOIUrl":"10.1016/j.pacs.2025.100752","url":null,"abstract":"<div><div>Accurate and rapid detection of hydrogen and hydrocarbons is critical for safety and efficiency in modern energy, industrial, and environmental systems. However, selective and simultaneous quantification of these species remains a significant technical challenge. Here, we introduce conductance–photoacoustic spectroscopy (ConPAS), an integrated sensing approach that combines conductance-based resonance modulation with quartz-enhanced photoacoustic spectroscopy in a single device. By bridging a quartz tuning fork (QTF) with a catalytic platinum microwire, ConPAS enables concurrent extraction of hydrogen and hydrocarbon concentrations from a unified electrical signal: hydrogen is quantified by frequency analysis, while hydrocarbon content is determined by amplitude analysis simultaneously. Experiments demonstrate minimum detection limits of 0.69 % for hydrogen, 40.26 ppm for propane, and 133.7 ppm for methane, with millisecond response time and excellent linearity (R² &gt; 0.99). The modular architecture allows flexible adaptation to other analytes via material substitution, offering a scalable and versatile solution for simultaneous, multi-component gas sensing. This work establishes ConPAS as a powerful, calibration-compatible platform for integrated gas analysis in hydrogen-enriched environments, with broad implications for safety monitoring, process control, and advanced energy applications.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"45 ","pages":"Article 100752"},"PeriodicalIF":6.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}