Photoacoustics最新文献_第2页

Quantitative photoacoustic imaging using known chromophores as fluence marker 定量光声成像使用已知的发色团作为通量标记。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100673

Anjali Thomas , Max Rietberg , Mervenur Akkus , Gijs van Soest , Kalloor Joseph Francis

{"title":"Quantitative photoacoustic imaging using known chromophores as fluence marker","authors":"Anjali Thomas , Max Rietberg , Mervenur Akkus , Gijs van Soest , Kalloor Joseph Francis","doi":"10.1016/j.pacs.2024.100673","DOIUrl":"10.1016/j.pacs.2024.100673","url":null,"abstract":"<div><div>Photoacoustic imaging offers optical contrast images of human tissue at acoustic resolution, making it valuable for diverse clinical applications. However, quantifying tissue composition via optical contrast remains challenging due to the unknown light fluence within the tissue. Here, we propose a method that leverages known chromophores (<em>e.g.</em>, arterial blood) to improve the accuracy of quantitative photoacoustic imaging. By using the optical properties of a known chromophore as a fluence marker and integrating it into the optical inversion process, we can estimate the unknown fluence within the tissue. Experimentally, we demonstrate that this approach successfully recovers both the spectral shape and magnitude of the optical absorption coefficient of an unknown chromophore. Additionally, we show that the fluence marker method enhances conventional optical inversion techniques, specifically (i) a straightforward iterative approach and (ii) a gradient-based method. Our results indicate an improvement in accuracy of up to 24.4% when comparing optical absorption recovery with and without the fluence marker. Finally, we present the method’s performance and illustrate its applications in carotid plaque quantification.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100673"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple optical path length reflections enhancement based on balloon-type photoacoustic cell for trace gas sensing 基于球囊型光声电池的多光程长度反射增强用于痕量气体传感。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100681

Ruiming Wu , Wenjun Ni , Chunyong Yang , Bingze He , Ping Lu , Sixiang Ran , Zhongke Zhao , Perry Ping Shum

{"title":"Multiple optical path length reflections enhancement based on balloon-type photoacoustic cell for trace gas sensing","authors":"Ruiming Wu , Wenjun Ni , Chunyong Yang , Bingze He , Ping Lu , Sixiang Ran , Zhongke Zhao , Perry Ping Shum","doi":"10.1016/j.pacs.2024.100681","DOIUrl":"10.1016/j.pacs.2024.100681","url":null,"abstract":"<div><div>A novel balloon-type photoacoustic cell (BTPAC) is proposed to facilitate the detection limitations of acetylene (C<sub>2</sub>H<sub>2</sub>) gas achieving ppb level. Here, an ellipsoidal photoacoustic cavity is employed as the platform for gas-light interaction. By strategically directing the excitation source towards the focal point of the ellipsoidal cavity, ensuring its trajectory traverses the focal point upon each reflection from the interior walls. This path increases the gas absorption path length and improves the efficiency of the laser-gas interaction process. Experimental results show that the quality factor of the BTPAC is 224.24 under normal temperature and pressure conditions. Notably, the system maintains a high signal-to-noise ratio even at a C<sub>2</sub>H<sub>2</sub> concentration of 0.1 ppm. Moreover, the minimum detection limit (MDL) and normalized noise equivalent absorption can be calculated to be 3.86 ppb, 6.94·10<sup>−10</sup> cm<sup>−1</sup>·W·Hz<sup>−1/2</sup>, respectively. Finally, the MDL of the sensor reaches to 0.71 ppb when the integration time reaches 100 s.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100681"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dichroism-sensitive photoacoustic imaging for in-depth estimation of the optic axis in fibrous tissue 用于纤维组织中光轴深度估计的二色敏感光声成像。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100676

Camilo Cano , Amir Gholampour , Marc van Sambeek , Richard Lopata , Min Wu

{"title":"Dichroism-sensitive photoacoustic imaging for in-depth estimation of the optic axis in fibrous tissue","authors":"Camilo Cano , Amir Gholampour , Marc van Sambeek , Richard Lopata , Min Wu","doi":"10.1016/j.pacs.2024.100676","DOIUrl":"10.1016/j.pacs.2024.100676","url":null,"abstract":"<div><div>Photoacoustic imaging (PAI) is a developing image modality that benefits from light–matter interaction and low acoustic attenuation to provide functional information on tissue composition at relatively large depths. Several studies have reported the potential of dichroism-sensitive photoacoustic (DS-PA) imaging to expand PAI capabilities by obtaining morphological information of tissue regarding anisotropy and predominant orientation. However, most of these studies have limited their analysis to superficial scanning of samples, where fluence effects are negligible. Herein, we present a mathematical model for the in-depth analysis of the DS-PA signal of biological samples, focusing on estimating tissue orientation. Our model is validated with a B-scan setup for DS-PA imaging in ex-vivo porcine tendon samples, for which collagen displays optical anisotropy. Results show that for in-depth DS-PA imaging, the accumulative fluence modulation due to dichroism overcomes the effect of absorption dichroism affecting the measured signals; however, this effect can be corrected based on the presented model for determining fiber orientation.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100676"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature dependence of femtosecond photoacoustic process in high-precision characterization for metal nanofilms 飞秒光声过程在金属纳米膜高精度表征中的温度依赖性。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100678

Zhongyu Wang , Jing Min , Yong Sun , Xuesong Wang , Xiuguo Chen , Zirong Tang , Shiyuan Liu

{"title":"Temperature dependence of femtosecond photoacoustic process in high-precision characterization for metal nanofilms","authors":"Zhongyu Wang , Jing Min , Yong Sun , Xuesong Wang , Xiuguo Chen , Zirong Tang , Shiyuan Liu","doi":"10.1016/j.pacs.2024.100678","DOIUrl":"10.1016/j.pacs.2024.100678","url":null,"abstract":"<div><div>Femtosecond photoacoustic detection is a powerful all-optical technique for characterizing metal nanofilms. However, the lack of accurate descriptions of the temperature-dependent optical properties of metal nanofilms during ultrafast thermal processes hinders the deep understanding of this dynamic behavior, leading to compromised measurement accuracy. To address this, we developed Critical Point Models (CPMs) for copper and AlCu nanofilms to describe their dynamic optical properties during photoacoustic testing. By integrating dynamic behavior into ultrafast laser-matter interaction and acousto-optic processes, we explored the temperature effects throughout testing. Numerical simulations were performed to analyze the temperature, stress, and surface reflectivity distributions of the nanofilms. Compared to experimental results, our dynamic models significantly improved prediction accuracy for both copper and AlCu nanofilms. This highlights the importance of temperature dependence in femtosecond photoacoustic testing and validates our model's capability to capture the behavior of metal nanofilms under ultrafast laser irradiation.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100678"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optomechanical energy enhanced BF-QEPAS for fast and sensitive gas sensing 用于快速灵敏气体传感的光机械能量增强型 BF-QEPAS。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100677

Weilin Ye , Linfeng He , Weihao Liu , Zhile Yuan , Kaiyuan Zheng , Guolin Li

{"title":"Optomechanical energy enhanced BF-QEPAS for fast and sensitive gas sensing","authors":"Weilin Ye , Linfeng He , Weihao Liu , Zhile Yuan , Kaiyuan Zheng , Guolin Li","doi":"10.1016/j.pacs.2024.100677","DOIUrl":"10.1016/j.pacs.2024.100677","url":null,"abstract":"<div><div>Traditional beat frequency quartz-enhanced photoacoustic spectroscopy (BF-QEPAS) are limited by short energy accumulation times and the necessity of a decay period, leading to weaker signals and longer measurement cycles. Herein, we present a novel optomechanical energy-enhanced (OEE-) BF-QEPAS technique for fast and sensitive gas sensing. Our approach employs periodic pulse-width modulation (PWM) of the laser signal with an optimized duty cycle, maintaining the quartz tuning fork's (QTF) output at a stable steady-state level by applying stimulus signals at each half-period and allowing free vibration in alternate half-periods to minimize energy dissipation. This method enhances optomechanical energy accumulation in the QTF, resulting in an approximate 33-fold increase in response speed and a threefold increase in signal intensity compared to conventional BF-QEPAS. We introduce an energy efficiency coefficient <em>K</em> to quantify the relationship between transient signal amplitude and measurement duration, exploring its dependence on the modulation signal's period and duty cycle. Theoretical analyses and numerical simulations demonstrate that the maximum <em>K</em> occurs at a duty cycle of 50 % and an optimized beat frequency Δ<em>f</em> of 30 Hz. Experimental results using methane reveal a detection limit of 2.17 ppm with a rapid response time of 33 ms. The OEE-BF-QEPAS technique exhibits a wide dynamic range with exceptional linearity over five orders of magnitude and a record noise-equivalent normalized absorption (NNEA) coefficient of 9.46 × 10<sup>−10</sup> W cm<sup>−1</sup> Hz<sup>−1/2</sup>. Additionally, a self-calibration method is proposed for correcting resonant frequency shifts. The proposed method holds immense potential for applications requiring fast and precise gas detection.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100677"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivariate-coupled-enhanced photoacoustic spectroscopy with Chebyshev rational fractional-order filtering algorithm for trace CH4 detection

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-01-31 DOI: 10.1016/j.pacs.2025.100692

Shenlong Zha , Hang Chen , Chen Liu , Yuxiang Guo , Hongliang Ma , Qilei Zhang , Lingli Li , Shengbao Zhan , Gang Cheng , Yanan Cao , Pan Pan

{"title":"Multivariate-coupled-enhanced photoacoustic spectroscopy with Chebyshev rational fractional-order filtering algorithm for trace CH4 detection","authors":"Shenlong Zha , Hang Chen , Chen Liu , Yuxiang Guo , Hongliang Ma , Qilei Zhang , Lingli Li , Shengbao Zhan , Gang Cheng , Yanan Cao , Pan Pan","doi":"10.1016/j.pacs.2025.100692","DOIUrl":"10.1016/j.pacs.2025.100692","url":null,"abstract":"<div><div>An innovative and miniature photoacoustic spectroscopy (PAS) gas sensor based on a multivariate-coupled amplification photoacoustic cell (MVCA-PAC) with a total length of 100 mm was developed to achieve ultra-sensitive trace CH<sub>4</sub> detection. Acoustic pressure distribution simulations reveal that at the first-order resonance frequency, the MVCA-PAC achieves a maximum acoustic pressure approximately 3.9 times higher than that of a conventional photoacoustic cell. The absorption optical path of the MVCA-PAC reached 2068 mm through 22 reflections, resulting in a 2-fold increase in the amplitude of photoacoustic signals compared to the traditional photoacoustic cell with an equivalent absorption optical path. Furthermore, compared to a single-pass photoacoustic cell, the <em>2-f</em> signal intensity of the MVCA-PAC increased by a factor of 4.5. Allan variance analysis indicated a detection limit of 0.572 ppm for CH<sub>4</sub> detection with an averaging time of approximately 300 s. To further improve the measurement precision of the designed sensor, the Chebyshev rational fractional-order filtering (CRFOF) algorithm was introduced for PAS signal processing for the first time. Post-processing results demonstrated a 15.4-fold improvement in measurement precision, achieving a precision of 0.578 ppm. Finally, continuous monitoring of atmospheric CH<sub>4</sub> over a 48-hour period validated the reliability and feasibility of the sensor.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"42 ","pages":"Article 100692"},"PeriodicalIF":7.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-01-29 DOI: 10.1016/j.pacs.2025.100693

Terese von Knorring , Tobias Buhl Ihlemann , Paul Blanche , Charlene Reichl , Niels Møller Israelsen , Caroline Meyer Olesen , Yasemin Topal Yüksel , Mette Mogensen

{"title":"Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging","authors":"Terese von Knorring , Tobias Buhl Ihlemann , Paul Blanche , Charlene Reichl , Niels Møller Israelsen , Caroline Meyer Olesen , Yasemin Topal Yüksel , Mette Mogensen","doi":"10.1016/j.pacs.2025.100693","DOIUrl":"10.1016/j.pacs.2025.100693","url":null,"abstract":"<div><div>Photoacoustic imaging (PAI) shows promise for skin cancer diagnosis by detecting chromophores like melanin, hemoglobin, lipids, and collagen. While most studies focus on malignant lesions, understanding normal skin variability across anatomical regions is crucial for validating PAI's clinical application and its use in melanoma diagnosis. We assessed normal skin in 20 healthy volunteers from three different body locations using a clinical PAI system and compared suspicious looking pigmented skin lesions, including melanomas, to adjacent normal skin (n = 74). Higher deoxyhemoglobin levels were observed in the ankle compared to the cheek and volar forearm, while melanin, lipids, and collagen showed minimal variation. Patients with malignant lesions had significantly higher deoxyhemoglobin levels (p = 0.001) than adjacent normal skin, a difference not seen in benign lesions. These findings suggest that PAI may help diagnose malignancies by identifying increased vascularity in skin cancers, while anatomical differences should be considered during diagnostic work-up.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"42 ","pages":"Article 100693"},"PeriodicalIF":7.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limited-view photoacoustic imaging reconstruction via high-quality self-supervised neural representation

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-01-23 DOI: 10.1016/j.pacs.2025.100685

Youshen Xiao , Yuting Shen , Sheng Liao , Bowei Yao , Xiran Cai , Yuyao Zhang , Fei Gao

{"title":"Limited-view photoacoustic imaging reconstruction via high-quality self-supervised neural representation","authors":"Youshen Xiao , Yuting Shen , Sheng Liao , Bowei Yao , Xiran Cai , Yuyao Zhang , Fei Gao","doi":"10.1016/j.pacs.2025.100685","DOIUrl":"10.1016/j.pacs.2025.100685","url":null,"abstract":"<div><div>In practical applications within the human body, it is often challenging to fully encompass the target tissue or organ, necessitating the use of limited-view arrays, which can lead to the loss of crucial information. Addressing the reconstruction of photoacoustic sensor signals in limited-view detection spaces has become a focal point of current research. In this study, we introduce a self-supervised network termed HIgh-quality Self-supervised neural representation (HIS), which tackles the inverse problem of photoacoustic imaging to reconstruct high-quality photoacoustic images from sensor data acquired under limited viewpoints. We regard the desired reconstructed photoacoustic image as an implicit continuous function in 2D image space, viewing the pixels of the image as sparse discrete samples. The HIS’s objective is to learn the continuous function from limited observations by utilizing a fully connected neural network combined with Fourier feature position encoding. By simply minimizing the error between the network’s predicted sensor data and the actual sensor data, HIS is trained to represent the observed continuous model. The results indicate that the proposed HIS model offers superior image reconstruction quality compared to three commonly used methods for photoacoustic image reconstruction.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"42 ","pages":"Article 100685"},"PeriodicalIF":7.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced clinical photoacoustic vascular imaging through a skin localization network and adaptive weighting

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-01-21 DOI: 10.1016/j.pacs.2025.100690

Chuqin Huang , Emily Zheng , Wenhan Zheng , Huijuan Zhang , Yanda Cheng , Xiaoyu Zhang , Varun Shijo , Robert W. Bing , Isabel Komornicki , Linda M. Harris , Ermelinda Bonaccio , Kazuaki Takabe , Emma Zhang , Wenyao Xu , Jun Xia

引用次数: 0

Robust and compact light-induced thermoelastic sensor for atmospheric methane detection based on a vacuum-sealed subminiature tuning fork

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-01-20 DOI: 10.1016/j.pacs.2025.100691

Zhijin Shang , Hongpeng Wu , Gang Wang , Ruyue Cui , Biao Li , Ting Gong , Guqing Guo , Xuanbing Qiu , Chuanliang Li , Lei Dong

{"title":"Robust and compact light-induced thermoelastic sensor for atmospheric methane detection based on a vacuum-sealed subminiature tuning fork","authors":"Zhijin Shang , Hongpeng Wu , Gang Wang , Ruyue Cui , Biao Li , Ting Gong , Guqing Guo , Xuanbing Qiu , Chuanliang Li , Lei Dong","doi":"10.1016/j.pacs.2025.100691","DOIUrl":"10.1016/j.pacs.2025.100691","url":null,"abstract":"<div><div>A compact light-induced thermoelastic spectroscopy (LITES) instrument incorporating a subminiature quartz tuning fork (QTF) was developed for atmospheric methane (CH<sub>4</sub>) sensing. The QTF features prong dimensions of 1700 µm in length and 120 µm in width, which enable substantial thermoelastic expansion at the microscale, significantly enhancing the piezoelectric signal. The subminiature QTF was vacuum sealed to achieve a high quality factor of 20,511 and a temperature coefficient of frequency of − 0.91 ppm/℃, ensuring a high detection sensitivity and robustness for the LITES sensor. Under identical vacuum conditions, the subminiature QTF demonstrated a twofold signal enhancement compared to the standard QTF, resulting in a minimum detection limit (MDL) of 47 ppb with a 300-ms averaging time. Continuous measurements of atmospheric CH<sub>4</sub> levels over five days were conducted to evaluate the accuracy and robustness of the developed sensor for long-duration monitoring applications.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"42 ","pages":"Article 100691"},"PeriodicalIF":7.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0