Photoacoustics最新文献

Multi-wavelength graph convolutional network for high-performance sparse multispectral optoacoustic tomography 高性能稀疏多光谱光声层析成像的多波长图卷积网络

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-10-09 DOI: 10.1016/j.pacs.2025.100775

Mengyang Lu , Jingxian Wang , Jiayuan Peng , Boyi Li , Xin Liu

{"title":"Multi-wavelength graph convolutional network for high-performance sparse multispectral optoacoustic tomography","authors":"Mengyang Lu , Jingxian Wang , Jiayuan Peng , Boyi Li , Xin Liu","doi":"10.1016/j.pacs.2025.100775","DOIUrl":"10.1016/j.pacs.2025.100775","url":null,"abstract":"<div><div>The rapid advancement of multispectral optoacoustic tomography (MSOT) has developed for label-free biomedical imaging by providing anatomical and functional visualization through multi-wavelength laser excitation and ultrasound detection. This technique offers high spatial resolution and deep-tissue imaging capabilities for biological applications. However, the substantial hardware cost and computational demand for high-quality <em>in vivo</em> imaging hinder its extensive development. To overcome these limitations, we propose a multi-wavelength graph convolutional network for sparse MSOT. Our approach solves the ill-conditioned sparse reconstruction problem through a graph learning framework integrated with a multi-wavelength sparse sampling strategy, which can model and leverage the intrinsic correlations in artifact distributions across diverse sparse transducer configurations. Comprehensive <em>in vivo</em> mouse experiments demonstrate that the proposed method provides a flexible and practical solution for high-performance sparse MSOT imaging under sparse conditions (16 transducer elements with the reconstruction SSIM of 0.92 ± 0.01 and PSNR of 27.74 ± 1.27).</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100775"},"PeriodicalIF":6.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-assisted laser ultrasound method for the estimation of porosity in hairpin weld seams 人工智能辅助激光超声评估发夹焊缝孔隙率的方法

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-10-08 DOI: 10.1016/j.pacs.2025.100770

Markus Saurer , Guenther Paltauf , Oliver Spitzer , Tobias Reitmayr , Gordana Djuras , Birgit Kornberger , Ulrike Kleb , Robert Nuster

{"title":"Artificial intelligence-assisted laser ultrasound method for the estimation of porosity in hairpin weld seams","authors":"Markus Saurer , Guenther Paltauf , Oliver Spitzer , Tobias Reitmayr , Gordana Djuras , Birgit Kornberger , Ulrike Kleb , Robert Nuster","doi":"10.1016/j.pacs.2025.100770","DOIUrl":"10.1016/j.pacs.2025.100770","url":null,"abstract":"<div><div>Hairpin technology is being used as a replacement for the traditional winding stator in electric motors. In hairpin stator manufacturing, copper rods are used to achieve a higher slot fill factor. These rods are joined together in pairs through laser welding, forming a closed circuit. However, this welding process is prone to air inclusions in the welds, which can negatively impact the efficiency and durability of the motor. The present study aims to estimate the total volume of these air inclusions using laser ultrasonic measurements. Laser ultrasound is a fast, non-contact, non-destructive method that can cope with the limited sample accessibility, making it ideal for inline testing of these weld seams. To evaluate the effectiveness of laser ultrasound, a stator was intentionally manipulated prior to laser welding to favor the formation of air inclusions. The porosity of the weld seams was determined through computed tomography images. It was demonstrated that due to the complex geometry of the hairpin welds, leading to a complex ultrasound wave field, standard methods to estimate the porosity from laser ultrasound B-scans are difficult to apply. As an alternative approach, an algorithm that is based on artificial intelligence was utilized for the purpose of estimating the air inclusion volume in the welds from laser ultrasonic measurements. The outcomes demonstrated a median correlation of 0.6 between this estimate and the pore volume obtained from the computed tomography data, despite the utilization of only 48 samples. Moreover, these results were evaluated against a model where the labels were randomly mixed, and highly informative regions regarding pore volume were identified in the B-scans, which have the potential to accelerate the process of acquiring data.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100770"},"PeriodicalIF":6.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PMUT enhanced light-induced thermoelastic spectroscopy PMUT增强光致热弹性光谱

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-09-28 DOI: 10.1016/j.pacs.2025.100772

Wei Wei , Kelu Zhou , Ruyue Cui , Zhengguo Shang , Hongpeng Wu , Lei Dong

{"title":"PMUT enhanced light-induced thermoelastic spectroscopy","authors":"Wei Wei , Kelu Zhou , Ruyue Cui , Zhengguo Shang , Hongpeng Wu , Lei Dong","doi":"10.1016/j.pacs.2025.100772","DOIUrl":"10.1016/j.pacs.2025.100772","url":null,"abstract":"<div><div>High-precision detection of acetylene (C₂H₂) concentration plays a vital role in industrial safety, environmental monitoring, and fault diagnosis of power equipment. This paper reports a highly sensitive light-induced thermoelastic spectroscopy (LITES) C₂H₂ sensor based on a piezoelectric micromachined ultrasound transducer (PMUT). The sensor employs an eight-cantilever PMUT structure at the micrometer scale as its sensing element, effectively converting minute thermal deformations into larger displacements to achieve enhanced mechanical amplification effects. The novel cantilever beam structure design increases the PMUT resonance frequency to a high frequency of 198.8 kHz while simultaneously enhancing the LITES signal by a factor of 45. A spot-concentrated miniature multi-pass cell designed for the novel PMUT structure further enhances detection sensitivity and stability by amplifying the optical path length by 70 times through optical folding. Experimental results demonstrate that the sensor exhibits excellent linear response (R² = 0.99936) and long-term stability for C₂H₂ concentration detection, achieving a minimum detection limit of 2 ppm (@64 s). Compared with existing C₂H₂ optical detection technologies, PMUT-based LITES C₂H₂ sensor not only demonstrates outstanding detection performance but also offers CMOS-compatible fabrication advantages, providing a novel approach for the development of highly sensitive, portable, easily integrated, and low-cost C₂H₂ detection systems.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100772"},"PeriodicalIF":6.8,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status 糖尿病性肌肉减少症的光声成像肌肉氧饱和度分层：与疾病状态的关系

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-09-27 DOI: 10.1016/j.pacs.2025.100771

Linxin Yang , Han Wu , Jing Chen , Wei Wang , Zhenxiu Zhang , Jiaping Feng , Wanbing Qiu , Fajin Dong , Ning Lin , Fengyi Yuan

{"title":"Muscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status","authors":"Linxin Yang , Han Wu , Jing Chen , Wei Wang , Zhenxiu Zhang , Jiaping Feng , Wanbing Qiu , Fajin Dong , Ning Lin , Fengyi Yuan","doi":"10.1016/j.pacs.2025.100771","DOIUrl":"10.1016/j.pacs.2025.100771","url":null,"abstract":"<div><div>Sarcopenia, commonly observed in diabetes, is characterized by reduced muscle mass and function. However, the relationship between muscle oxygen saturation (SO₂) and sarcopenia remains unclear. Photoacoustic imaging (PAI) offers a promising method for assessment. This study aimed to evaluate SO₂ distribution in diabetic sarcopenic patients using PAI and explore associations with clinical parameters. Type 2 diabetes patients (≥ 10 years) underwent PAI of the gastrocnemius and vastus lateralis muscles. Sarcopenia was diagnosed by AWGS 2019/2020 criteria. SO₂ values stratified patients into hypoxia, intermediate, and hyperoxia groups. The study included 64 sarcopenic and 115 non-sarcopenic patients. Mean SO₂ was significantly lower in sarcopenia (63.28 % vs. 66.26 %, P < 0.001). PAI-measured SO₂ was an independent protective factor (β = −0.10, P = 0.001). In conclusion, PAI-assessed SO₂ is associated with sarcopenia and may serve as an early screening biomarker.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100771"},"PeriodicalIF":6.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-pass differential photoacoustic spectrometer at 1064 nm for ambient aerosol absorption 1064 nm的多通差分光声光谱仪用于环境气溶胶吸收

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-09-10 DOI: 10.1016/j.pacs.2025.100769

Jie Chen , Xianmei Qian , Wenyue Zhu , Qiang Liu , Jianjie Zheng , Tao Yang , Tengfei Yang

引用次数: 0

Contrast-enhanced multispectral optoacoustic tomography for the assessment of the gastrointestinal transit in patients with cystic fibrosis 对比增强多光谱光声断层扫描对囊性纤维化患者胃肠道运输的评估

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-09-10 DOI: 10.1016/j.pacs.2025.100766

Johanna Fuchte, Felix Wachter, Merle Claßen, Hannah Vogt-Wolz, Lars-Philip Paulus, Henriette Mandelbaum, Adrian Buehler, Gregor Siebenlist, Jörg Jüngert, Joachim Wölfle, André Hörning, Ferdinand Knieling, Adrian P. Regensburger , Alexander Schnell

{"title":"Contrast-enhanced multispectral optoacoustic tomography for the assessment of the gastrointestinal transit in patients with cystic fibrosis","authors":"Johanna Fuchte, Felix Wachter, Merle Claßen, Hannah Vogt-Wolz, Lars-Philip Paulus, Henriette Mandelbaum, Adrian Buehler, Gregor Siebenlist, Jörg Jüngert, Joachim Wölfle, André Hörning, Ferdinand Knieling, Adrian P. Regensburger , Alexander Schnell","doi":"10.1016/j.pacs.2025.100766","DOIUrl":"10.1016/j.pacs.2025.100766","url":null,"abstract":"<div><div>Cystic fibrosis (CF) affects the gastrointestinal tract, but assessing gastrointestinal transit usually requires invasive procedures or exposure to ionizing radiation. Contrast-enhanced multispectral optoacoustic tomography (CE-MSOT) offers a novel, non-invasive, and radiation-free approach to assess gastrointestinal function by orally administered dyes. In this clinical pilot-study five patients with cystic fibrosis and four healthy volunteers received CE-MSOT before and 6-times hourly after a standardized breakfast with Indocyanin green (ICG) as dye. The gastric antrum, terminal ileum and sigmoid colon were recorded and MSOT signals spectrally unmixed to detect ICG signals to determine the transit time. ICG excretion was confirmed by fluorescence imaging of stool samples. MSOT ICG signals were detected earlier in the terminal ileum of CF patients, reaching a maximum after 120 min (p = 0.0079), compared to 240 min (p = 0.0286) in healthy controls after ICG intake (p = 0.0159). In CF patients, ICG signal was further detected in the sigmoid colon from 240 min onwards (p = 0.0079 after 300 min). But, no significant changes in the ICG signal were observed in the sigmoid colon of controls. Furthermore, signals of ICG were verified in 12 of 19 stool samples by fluorescence imaging. In this study, we demonstrated the potential of CE-MSOT for functional imaging of the intestine in CF patients and revealed faster intestinal transit in CF patients compared to healthy controls.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100766"},"PeriodicalIF":6.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoacoustic spectroscopy detection based on complementary interdigital cantilever enhanced Fabry-Perot acoustic sensor 基于互补数字间悬臂增强法布里-珀罗声传感器的光声光谱检测

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-09-08 DOI: 10.1016/j.pacs.2025.100768

Chongyue Yan , Qiaoyun Wang , Tianyu Li , Zhiqi Gao , Yinji Chen , Ziheng Zhu , Zhigang Li , Dongxiao Hou , Qiang Liu

{"title":"Photoacoustic spectroscopy detection based on complementary interdigital cantilever enhanced Fabry-Perot acoustic sensor","authors":"Chongyue Yan , Qiaoyun Wang , Tianyu Li , Zhiqi Gao , Yinji Chen , Ziheng Zhu , Zhigang Li , Dongxiao Hou , Qiang Liu","doi":"10.1016/j.pacs.2025.100768","DOIUrl":"10.1016/j.pacs.2025.100768","url":null,"abstract":"<div><div>Photoacoustic spectroscopy (PAS) has been widely used for detecting trace gases, but enhancing sound pressure detection capability of the acoustic sensor is crucial for improving gas detection sensitivity of the PAS system. In this paper, a complementary interdigital (CID) cantilever Fabry-Perot (F-P) fiber optic acoustic sensor (FOAS) was developed. Experimental results demonstrated that the CID cantilever operated at its resonance frequency of 1010 Hz exhibited a high sensitivity of 923.7 nm/Pa, and exhibited a signal-to-noise ratio of 72.2 dB and a minimum detectable pressure of 16.4 μPa/Hz <sup>1/2</sup> at 1 kHz. In the concentration range of 20 ppm to 100 ppm, the sensitivity of PAS to C₂H₂ gas was 3.02 pm/ppm and the detection limits of C₂H₂ in N₂ background was 30.17 ppb. This design employs highly sensitive cantilevers with tunable resonance, enhancing the gas detection sensitivity of the PAS system by leveraging resonant frequency matching and signal amplification.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100768"},"PeriodicalIF":6.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological optimization method “MMA-BP” for photoacoustic resonator and implementations in ppt-level gas sensor using miniaturized vase-type photoacoustic cells 光声谐振器拓扑优化方法“MMA-BP”及其在微型花瓶型光声电池pt级气体传感器中的实现

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-09-05 DOI: 10.1016/j.pacs.2025.100767

Wenzhe Wang , Zhiyu Feng , Yachao Jiang , Jie Zhang , Shiyu Yan , Xiaohong Cao , Ping Lu , Chaotan Sima

{"title":"Topological optimization method “MMA-BP” for photoacoustic resonator and implementations in ppt-level gas sensor using miniaturized vase-type photoacoustic cells","authors":"Wenzhe Wang , Zhiyu Feng , Yachao Jiang , Jie Zhang , Shiyu Yan , Xiaohong Cao , Ping Lu , Chaotan Sima","doi":"10.1016/j.pacs.2025.100767","DOIUrl":"10.1016/j.pacs.2025.100767","url":null,"abstract":"<div><div>A topological optimization method for photoacoustic resonators is proposed as the Method of Moving Asymptotes with Bernstein Polynomials (MMA-BP). This method is demonstrated in a ppt-level ultra-sensitive photoacoustic spectroscopy gas sensor using miniaturized vase-type photoacoustic cell (V-PAC). The V-PAC has a volume of merely 5 mL and achieves a minimum detection limit of 281 ppt for C<sub>2</sub>H<sub>2</sub> with an integration time of 768 s, corresponding to a normalized noise equivalent absorption of 4.46 × 10⁻<sup>9</sup>∙cm⁻<sup>1</sup>∙Hz⁻<sup>1/2</sup> with a single optical path. It represents an improvement of approximately 14 times beyond that of using the conventional T-type PAC. We experimentally investigated consequent frequency shifts within conventional PACs with thin resonator tubes, and determined the influence of losses on the resonant frequency shift. The geometric contraction effect in vase-type PAC is also investigated. The proposed topological MMA-BP method and implementations provide a universal approach to establish optimized PAC structures for photoacoustic gas detection.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100767"},"PeriodicalIF":6.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multimodal approach to assess a liposomal carrier’s biodistribution, stability, and clearance 评估脂质体载体的生物分布、稳定性和清除的多模式方法

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-08-22 DOI: 10.1016/j.pacs.2025.100763

Cayla A. Wood , Claire E. Jones , Ananthakrishnan Soundaram Jeevarathinam, Riley Watson, Sangheon Han, Jennifer Meyer, Konstantin V. Sokolov, Richard R. Bouchard

{"title":"A multimodal approach to assess a liposomal carrier’s biodistribution, stability, and clearance","authors":"Cayla A. Wood , Claire E. Jones , Ananthakrishnan Soundaram Jeevarathinam, Riley Watson, Sangheon Han, Jennifer Meyer, Konstantin V. Sokolov, Richard R. Bouchard","doi":"10.1016/j.pacs.2025.100763","DOIUrl":"10.1016/j.pacs.2025.100763","url":null,"abstract":"<div><div>Liposomal carriers, used for site-specific drug delivery, are being investigated for diagnostic approaches by replacing the therapeutic with an imaging contrast agent, exploring potential for selective treatment planning. There remains a critical need to improve <em>in vivo</em> assessment of biodistribution, stability, and clearance kinetics of liposomal carriers. This pilot study presents a multimodal approach in which liposome-encapsulated J-aggregated indocyanine green (ICG) dye (Lipo-JICG) is imaged with high spatial resolution using both <em>in vivo</em> photoacoustic (PA) imaging, to assess the absorbance characteristics of JICG and monomeric ICG, and <em>ex vivo</em> cryofluorescence tomography (CFT), to measure ICG fluorescence. An <em>in vitro</em> assay comparing the relationship between absorbance and fluorescence of Lipo-JICG and ICG demonstrated that the absorbance peak shifted from 780 to 895 nm as the Lipo-JICG:ICG ratio increased; meanwhile, the fluorescence decreased drastically as the Lipo-JICG:ICG ratio increased, demonstrating that J-aggregation quenches fluorescence. Twelve mice were then PA imaged pre-injection, then up to 6 days after Lipo-JICG injection. Unmixed Lipo-JICG signal peaked at 30 min post-injection in both liver and spleen; unmixed ICG signal peaked post-injection, decreasing over time in both organs and increasing at 6 days in the spleen. With CFT, ICG fluorescence followed a similar trend, with a maximum at 30 min in liver and at 6 days in spleen, implying that Lipo-JICG continued to break down and excrete through the hepatic system over 6 days post-injection. Future studies will continue to develop this methodology to assess biodistribution, stability, and clearance of liposomal carriers in tumor-bearing murine models.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"46 ","pages":"Article 100763"},"PeriodicalIF":6.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Fourier-Derivative Analysis: An accurate and fast method for blood flow quantification in photoacoustic microscopy 混合傅立叶导数分析：一种准确、快速的光声显微镜血流定量方法

IF 6.8 1区医学

Photoacoustics Pub Date : 2025-08-21 DOI: 10.1016/j.pacs.2025.100761

Zhuoying Wang, Ziang Feng, Song Hu

引用次数: 0