Photoacoustics最新文献

Dual-modality ultrasound/photoacoustic tomography for mapping tissue oxygen saturation distribution in intestinal strangulation 用于绘制肠绞窄患者组织氧饱和度分布图的双模式超声波/照相声断层成像技术

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-04-01 DOI: 10.1016/j.pacs.2025.100721

Jie Zhou , Mengchuan Ou , Bo Yuan , Binzi Yan , Xichuan Wang , Shuaiqi Qiao , Yijie Huang , Lian Feng , Lin Huang , Yan Luo

{"title":"Dual-modality ultrasound/photoacoustic tomography for mapping tissue oxygen saturation distribution in intestinal strangulation","authors":"Jie Zhou , Mengchuan Ou , Bo Yuan , Binzi Yan , Xichuan Wang , Shuaiqi Qiao , Yijie Huang , Lian Feng , Lin Huang , Yan Luo","doi":"10.1016/j.pacs.2025.100721","DOIUrl":"10.1016/j.pacs.2025.100721","url":null,"abstract":"<div><div>The strangulation of intestinal obstruction (IO) presents challenges in the assessment of disease progression and surgical decision-making. Intraoperatively, an accurate evaluation of the status of the IO is critical for determining the extent of surgical resection. Dual-modality ultrasound/photoacoustic tomography (US/PAT) imaging has the potential to provide spatially resolved tissue oxygen saturation (SO₂), serving as a valuable marker for IO diagnosis. In this study, US/PAT was utilized for imaging rat models of IO, with the data used for reconstruction, statistical analysis, and distribution evaluation. Results showed that SO₂ decreased with increasing strangulation severity. Notably, the kurtosis and skewness of the SO₂ distribution outperformed SO₂ itself in diagnosis, as they more effectively capture the heterogeneity of SO₂ distribution. Kurtosis reflects distribution concentration, while skewness measures asymmetry, both achieving areas under the receiver operating characteristic curve (AUROC) of 0.969. In conclusion, US/PAT offers a rapid and convenient method for assessing strangulation in IO.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100721"},"PeriodicalIF":7.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High resolution photoacoustic vascular image reconstruction through the fast residual dense generative adversarial network

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-04-01 DOI: 10.1016/j.pacs.2025.100720

Yameng Zhang , Hua Tian , Min Wan , Shihao Tang , Ziyun Ding , Wei Huang , Yamin Yang , Weitao Li

{"title":"High resolution photoacoustic vascular image reconstruction through the fast residual dense generative adversarial network","authors":"Yameng Zhang , Hua Tian , Min Wan , Shihao Tang , Ziyun Ding , Wei Huang , Yamin Yang , Weitao Li","doi":"10.1016/j.pacs.2025.100720","DOIUrl":"10.1016/j.pacs.2025.100720","url":null,"abstract":"<div><div>Photoacoustic imaging is a powerful technique that provides high-resolution, deep tissue imaging. However, the time-intensive nature of photoacoustic microscopy (PAM) poses a significant challenge, especially when high-resolution images are required for real-time applications. In this study, we proposed an optimized Fast Residual Dense Generative Adversarial Network (FRDGAN) for high-quality PAM reconstruction. Through dataset validation on mouse ear vasculature, FRDGAN demonstrated superior performance in image quality, background noise suppression, and computational efficiency across multiple down-sampling scales (×4, ×8) compared to classical methods. Furthermore, in the in vivo experiments of mouse cerebral vasculature, FRDGAN achieves the improvement of 2.24 dB and 0.0255 in peak signal-to-noise ratio and structural similarity metrics in contrast to SRGAN, respectively. Our FRDGAN method provides a promising solution for fast, high-quality PAM microvascular imaging in biomedical research.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100720"},"PeriodicalIF":7.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodissociation-driven photoacoustic spectroscopy with UV-LEDs for ozone detection

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-29 DOI: 10.1016/j.pacs.2025.100718

Lukas Escher , Thomas Rück , Simon Jobst , Jonas Pangerl , Rudolf Bierl , Frank-Michael Matysik

引用次数: 0

Harnessing evanescent photoacoustic waves for multi-domain imaging

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-29 DOI: 10.1016/j.pacs.2025.100719

Rong Zhou , Liying Zhang , Beibei Li , Jingtao Xiao , Yiheng Xing , Chang Chen , Yuecheng Shen , Hao Shen , Deng Pan , Hongxing Xu

{"title":"Harnessing evanescent photoacoustic waves for multi-domain imaging","authors":"Rong Zhou , Liying Zhang , Beibei Li , Jingtao Xiao , Yiheng Xing , Chang Chen , Yuecheng Shen , Hao Shen , Deng Pan , Hongxing Xu","doi":"10.1016/j.pacs.2025.100719","DOIUrl":"10.1016/j.pacs.2025.100719","url":null,"abstract":"<div><div>Photoacoustic microscopy (PAM) offers a non-invasive imaging method that overcomes the limitations of light scattering in biological tissues by visualizing optical contrast through the detection of photo-generated acoustic signals. While optical microscopy has significantly advanced through the exploration of optical evanescent waves, the potential of evanescent photoacoustic (PA) waves in PAM remains largely unexplored. In this work, we demonstrate the generation and detection of evanescent PA waves in PAM by positioning the sample near an interface, which directs these waves into the far-field beyond the supercritical angle (SA). These SA-PA signals exhibit distinct characteristics, including dependence of intensity on the source depths and symmetry in far-field angular patterns. Leveraging these features, we develop a proof-of-concept for supercritical angle photoacoustic microscopy (SA-PAM), which utilizes evanescent PA waves to enable new PAM functionalities, such as surface topography reconstruction and edge detection. This approach highlights the role of acoustic near-field exploration in advancing PA technology.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100719"},"PeriodicalIF":7.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in optical fiber-based gas sensors utilizing light-induced acoustic/elastic techniques

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-28 DOI: 10.1016/j.pacs.2025.100715

Yuhui Liu , Yue Qi , Yangjian Cai , Xiaoyi Bao , Song Gao

引用次数: 0

A clinical feasibility study of a photoacoustic finder for sentinel lymph node biopsy in breast cancer patients: A prospective cross-sectional study

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-28 DOI: 10.1016/j.pacs.2025.100716

Moongyu Han , Young Joo Lee , Junho Ahn , Sunghun Nam , Minseong Kim , Jeongwoo Park , Joongho Ahn , Hanyoung Ryu , Youngseok Seo , Byullee Park , Dooreh Kim , Chulhong Kim

{"title":"A clinical feasibility study of a photoacoustic finder for sentinel lymph node biopsy in breast cancer patients: A prospective cross-sectional study","authors":"Moongyu Han , Young Joo Lee , Junho Ahn , Sunghun Nam , Minseong Kim , Jeongwoo Park , Joongho Ahn , Hanyoung Ryu , Youngseok Seo , Byullee Park , Dooreh Kim , Chulhong Kim","doi":"10.1016/j.pacs.2025.100716","DOIUrl":"10.1016/j.pacs.2025.100716","url":null,"abstract":"<div><div>The sentinel lymph node (SLNb) is generally performed using radioisotopes, blue dyes, or both to improve false negative rate. However, ionizing radiation is involved in a gamma probe with radioisotopes and the blue dye detection relies on native visual inspection by an operator. To overcome these limitations, we developed the photoacoustic finder (PAF), a highly sensitive, non-radioactive detector that uses only blue dye and a photoacoustic signal to detect SLNs. A total of 121 patients with breast cancer were enrolled, and 375 lymph nodes were excised using conventional SLNb. The PAF was used to measure the signal from the excised lymph nodes. We compared the SLN detection rates of each method (gamma probe, visual inspection, and PAF) and conducted a non-inferiority test. The PAF detected 87 % of SLNs, comparable to the gamma probe (85 %) and superior to visual inspection (73 %). Non-inferiority tests confirmed PAF's performance was not inferior to visual inspection (p < 0.001) or the gamma probe (p < 0.015). Using the dual-modal method (gamma probe + visual inspection) as the gold standard, PAF showed a sensitivity of 0.81 and specificity of 0.63. This study demonstrates that PAF, using only blue dye, offers a non-inferior alternative to the standard dual-modal SLN detection method with radioactive materials, opening new avenues for radiation-free SLNb in the future.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100716"},"PeriodicalIF":7.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gas concentration prediction in photoacoustic spectroscopy using PSO-EAP-CNN to address correlation degradation

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-28 DOI: 10.1016/j.pacs.2025.100717

Zhanshang Su , Pengpeng Wang , Zhengzhuo Li , Yawen Li , Tianxiang Zhao , Yujie Duan , Fupeng Wang , Cunguang Zhu

{"title":"Gas concentration prediction in photoacoustic spectroscopy using PSO-EAP-CNN to address correlation degradation","authors":"Zhanshang Su , Pengpeng Wang , Zhengzhuo Li , Yawen Li , Tianxiang Zhao , Yujie Duan , Fupeng Wang , Cunguang Zhu","doi":"10.1016/j.pacs.2025.100717","DOIUrl":"10.1016/j.pacs.2025.100717","url":null,"abstract":"<div><div>Photoacoustic spectroscopy (PAS) gas detection is frequently compromised by noise-induced correlation degradation, which significantly impacts measurement accuracy. To mitigate this issue, an advanced convolutional neural network (CNN) architecture, termed PSO-EAP-CNN, is proposed, which combines particle swarm optimization (PSO) with an ensemble augmented prediction (EAP) strategy. The proposed framework employs a multi-scale feature extraction mechanism through its convolutional architecture, while simultaneously optimizing network parameters via PSO, thereby achieving accelerated convergence and improved prediction stability. The incorporation of the EAP strategy further enhances the model's robustness and generalization ability under noisy conditions. Experimental results demonstrate significant improvements: compared to baseline CNN, PSO-EAP-CNN reduces MAE by 43.76 %, RMSE by 39.25 %, and MAPE by 51.15 %; compared to ordinary least squares regression, improvements reach 68.55 %, 67.43 %, and 75.21 % respectively. The model runs in only 10 seconds per execution. This work advances PAS-based gas detection, offering enhanced accuracy and noise resilience for practical trace gas analysis.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100717"},"PeriodicalIF":7.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative ultrasound and photoacoustic assessments of red blood cell aggregation in the human radial artery

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-13 DOI: 10.1016/j.pacs.2025.100711

Taehoon Bok , Eno Hysi , Michael C. Kolios

{"title":"Quantitative ultrasound and photoacoustic assessments of red blood cell aggregation in the human radial artery","authors":"Taehoon Bok , Eno Hysi , Michael C. Kolios","doi":"10.1016/j.pacs.2025.100711","DOIUrl":"10.1016/j.pacs.2025.100711","url":null,"abstract":"<div><div>We develop concurrent US and photoacoustic (PA) imaging to characterize structural/physiological impact of in-vivo red blood cell (RBC) aggregation. PA images at 700/800/900 nm were collected from the radial arteries of 12 participants across age groups (20 s/30 s/40 s) alongside US images (21 MHz, VevoLAZR). RBC aggregate size was estimated from US-derived structure-factor-size-estimation (<em>D</em><sub>SFSE</sub>) and PA-derived spectral-slope (SS), along with oxygen saturation (sO<sub>2</sub>). At peak systole (PS), <em>D</em><sub>SFSE</sub><sup>PS</sup> and SS<sup>PS</sup> approximated 1 RBC and −0.1 dB/MHz, respectively, across all ages, with sO<sub>2</sub><sup>PS</sup> values of 97.1 %, 94.7 %, and 93.0 % for each group. At end diastole (ED), <em>D</em><sub>SFSE</sub><sup>ED</sup>, SS<sup>ED</sup> and sO<sub>2</sub><sup>ED</sup> values were 2.6, 3.4, and 4.7 RBCs; −0.7, −0.9, and −1.2 dB/MHz; and 98.7 %, 97.2 %, and 96.7 %, respectively. Differences between SS<sup>ED</sup> and SS<sup>PS</sup> (δSS) and sO<sub>2</sub><sup>ED</sup> and sO<sub>2</sub><sup>PS</sup> (δsO<sub>2</sub>) increased with age, indicating aging-related increases in DSFSE and δSS, as well as decreases in sO<sub>2</sub><sup>PS</sup> and sO<sub>2</sub><sup>ED</sup>.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100711"},"PeriodicalIF":7.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo 3D photoacoustic and ultrasound analysis of hypopigmented skin lesions: A pilot study

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-08 DOI: 10.1016/j.pacs.2025.100705

Minseong Kim , Ju Hee Han , Junho Ahn , Esther Kim , Chul Hwan Bang , Chulhong Kim , Ji Hyun Lee , Wonseok Choi

{"title":"In vivo 3D photoacoustic and ultrasound analysis of hypopigmented skin lesions: A pilot study","authors":"Minseong Kim , Ju Hee Han , Junho Ahn , Esther Kim , Chul Hwan Bang , Chulhong Kim , Ji Hyun Lee , Wonseok Choi","doi":"10.1016/j.pacs.2025.100705","DOIUrl":"10.1016/j.pacs.2025.100705","url":null,"abstract":"<div><div>Vitiligo needs early identification for proper intervention. Current adjunct diagnostic methods rely mostly on subjective visual inspection. Thus, identification of early or atypical vitiligo lesions among other hypopigmentation disorders may pose challenges. To overcome this, we investigate the feasibility of a three-dimensional (3D) photoacoustic (PA) and ultrasound (US) imaging technique as a new adjuvant analytic tool providing quantitative characterization of hypopigmentation features. This cross-sectional study was conducted at Seoul St. Mary’s Hospital (Seoul, Republic of Korea) between August 2022 and January 2024. Lesions diagnosed vitiligo or IGH in locations that could safely be irradiated with laser were analyzed with 3D PA/US imaging along with the conventional diagnostic methods. A total of 53 lesions consisted of 36 vitiligo lesions and 17 IGH lesions from 39 participants with confirmed diagnosis were analyzed. The PA amplitude greatly differed between normal skin and hypopigmentation lesions, and the mean PA amplitudes of vitiligo lesions were slightly higher than that of IGH [mean (standard deviation, SD): vitiligo: 0.117 (0.043); IGH: 0.135 (0.028)]. The local SD of the PA amplitude were higher in IGH than in vitiligo lesions [vitiligo: 0.043 (0.018); IGH: 0.067 (0.017)]. The mean PA slope across the lesion boundary was significantly higher in IGH than in vitiligo [vitiligo: 0.173 (0.061); IGH: 0.342 (0.099)], whereas the PA peak depth was deeper in vitiligo than in IGH [vitiligo: 0.568 (0.262); IGH: 0.266 (0.116)]. Unlike conventional qualitative methods, 3D PA/US imaging can non-invasively provide quantitative metrics which might aid in the differentiation of vitiligo from IGH lesions.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100705"},"PeriodicalIF":7.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generative priors-constraint accelerated iterative reconstruction for extremely sparse photoacoustic tomography boosted by mean-reverting diffusion model: Towards 8 projections

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-03-08 DOI: 10.1016/j.pacs.2025.100709

Teng Lian , Yichen Lv , Kangjun Guo , Zilong Li , Jiahong Li , Guijun Wang , Jiabin Lin , Yiyang Cao , Qiegen Liu , Xianlin Song

{"title":"Generative priors-constraint accelerated iterative reconstruction for extremely sparse photoacoustic tomography boosted by mean-reverting diffusion model: Towards 8 projections","authors":"Teng Lian , Yichen Lv , Kangjun Guo , Zilong Li , Jiahong Li , Guijun Wang , Jiabin Lin , Yiyang Cao , Qiegen Liu , Xianlin Song","doi":"10.1016/j.pacs.2025.100709","DOIUrl":"10.1016/j.pacs.2025.100709","url":null,"abstract":"<div><div>As a novel non-invasive hybrid biomedical imaging technology, photoacoustic tomography combines the advantages of high contrast of optical imaging and high penetration of acoustic imaging. However, the conventional standard reconstruction methods under sparse view may lead to low-quality image in photoacoustic tomography. To address this problem, an advanced sparse reconstruction method for photoacoustic tomography based on the mean-reverting diffusion model is proposed. By modeling the degradation process from a high-quality image under full-view scanning (512 projections) to a sparse image with stable Gaussian noise (i.e., mean state), a mean-reverting diffusion model is trained to learn prior information of the data distribution. Then the learned prior information is employed to generate a high-quality image from the sparse image by iteratively sampling the noisy state. Blood vessels simulation data and the animal <em>in vivo</em> experimental data were used to evaluate the performance of the proposed method. The results demonstrate that the proposed method achieves higher-quality sparse reconstruction compared with conventional reconstruction methods and U-Net method. In addition, the proposed method dramatically speeds up the sparse reconstruction and achieves better reconstruction results for extremely sparse images compared with the method based on conventional diffusion model. The proposed method achieves an improvement of 0.52 (∼289 %) in structural similarity and 10.01 dB (∼59 %) in peak signal-to-noise ratio for extremely sparse projections (8 projections), compared with the conventional delay-and-sum method. This method is expected to shorten the acquisition time and reduce the cost of photoacoustic tomography, thus further expanding the range of applications.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"43 ","pages":"Article 100709"},"PeriodicalIF":7.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0