Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Impact of intraoperative hypotension on postoperative nausea and vomiting in patients undergoing orthognathic surgery","authors":"Sulin Tang,&nbsp;Rongrong Huang,&nbsp;Lili Guo,&nbsp;Liwei Jin,&nbsp;Yanli Zhang,&nbsp;Xia Zhang","doi":"10.1016/j.jormas.2025.102612","DOIUrl":"10.1016/j.jormas.2025.102612","url":null,"abstract":"<div><h3>Introduction</h3><div>To evaluate the risk factors for postoperative nausea and vomiting (PONV) in patients undergoing orthognathic surgery, with particular emphasis on elucidating the potential relationship between PONV and the depth and duration of intraoperative hypotension (IOH).</div></div><div><h3>Material and methods</h3><div>We conducted a retrospective cohort study of patients who underwent orthognathic surgery between November 2022 and August 2024. Mean arterial pressure (MAP) was extracted from electronic medical records. Methods to evaluate IOH: 1. total area under curve (AUC); 2. time-weighted average (TWA) MAP; 3. cumulative time below absolute threshold values; 4. cumulative time in the lowest MAP categories. MAP thresholds were defined by absolute limits (≤ 65, ≤ 60, ≤ 55 mmHg).</div></div><div><h3>Results</h3><div>Of the 287 patients enrolled, five patients were excluded. At all absolute thresholds, patients experiencing PONV demonstrated significantly greater AUC and TWA than non-PONV patients (<em>p</em> &lt; 0.05). Furthermore, at ≤ 60 and ≤ 55 mmHg threshold, PONV patients also exhibited significantly longer cumulative time of hypotensive (<em>p</em> &lt; 0.05). When MAP is in 50–60 mmHg range for &gt; 10 min (OR: 6.00, 95 % CI: 1.02–35.37), and when MAP is in ≤ 55 mmHg range for ≥ 5 min (OR: 0.42, 95 % CI: 0.20–0.90), were significantly associated with PONV (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>IOH may represent an additional important risk factor for PONV in patients undergoing orthognathic surgery, especially when MAP is in 50–60 mmHg range for &gt; 10 min, or ≤ 55 mmHg range for ≥ 5 min.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102612"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of trans-sutural distraction osteogenesis on the nasomaxillary complex in adolescents with cleft lip and palate","authors":"Yun He ,&nbsp;Zhongxing Wu","doi":"10.1016/j.jormas.2025.102595","DOIUrl":"10.1016/j.jormas.2025.102595","url":null,"abstract":"<div><h3>Introduction</h3><div>Trans-sutural distraction osteogenesis (TSDO) has emerged as a promising treatment for midfacial hypoplasia. However, the mechanical effects on craniofacial structures remain insufficiently understood.</div></div><div><h3>Material &amp; Method</h3><div>Finite element models (FEM) of two adolescent patients with cleft lip and palate (CLP) (aged 10 and 11) were reconstructed from CBCT data. TSDO was simulated by applying symmetrical traction forces to the maxilla. A modified surgical intervention, transanterior maxillary wall osteotomy, was also modeled to assess its biomechanical impact. Displacement and stress distribution were evaluated using total deformation, first and third principal stresses, and Von-Mises stress.</div></div><div><h3>Results</h3><div>TSDO induced forward displacement of the midface, especially in the alveolar process, with additional movement in the nasal, infraorbital, and zygomatic regions. Stress concentrations were observed around the traction hooks, nasomaxillary suture, and nasal septum. The cleft palate model exhibited more asymmetrical and uneven stress distribution. The simulated transanterior maxillary wall osteotomy significantly reduced stress in the nasal-infraorbital-zygomatic region while preserving maxillary advancement.</div></div><div><h3>Discussion</h3><div>TSDO effectively advances the midface in CLP patients but may result in undesirable protrusion in the nasal-infraorbital-zygomatic region. Transanterior maxillary wall osteotomy shows potential for mitigating these effects.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102595"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of iliac and fibula graft reconstructions compared to healthy mandibles: A finite element analysis study","authors":"O. Yildirim ,&nbsp;A. Ozkan ,&nbsp;M.S. Yolal","doi":"10.1016/j.jormas.2025.102599","DOIUrl":"10.1016/j.jormas.2025.102599","url":null,"abstract":"<div><h3>Introduction</h3><div>Mandibular continuity defects following tumor resection or trauma are commonly reconstructed using vascularized iliac crest or fibula grafts. The biomechanical implications of these grafts on implant-supported prosthetic rehabilitation remain unclear.</div></div><div><h3>Materials and Methods</h3><div>This study employed finite element analysis (FEA) to evaluate stress distribution in three mandibular models: a control model (CM), an iliac crest graft model (IM), and a fibula graft model (FM). A segmental defect was created from the right premolar to the mandibular angle and reconstructed using either iliac or fibula grafts. Each model received six implants, multi-unit abutments, and a bar-retained acrylic prosthesis. Simulations were performed under vertical loading in the central incisor, premolar, and molar regions. Von Mises stress values were analyzed in peri‑implant bone, implants, abutments, prostheses, and graft junction areas.</div></div><div><h3>Results</h3><div>The highest stress values were observed in the fibula model under molar loading. Maximum peri‑implant stress in the posterior graft junction reached 39.483 MPa in FM, compared to 20.340 MPa in IM. Implant and prosthetic component stresses were also highest in FM under functional loading. Iliac models generally exhibited lower and more evenly distributed stresses across all conditions.</div></div><div><h3>Conclusion</h3><div>The type of graft significantly influences biomechanical performance in mandibular reconstructions. Fibula grafts demonstrated higher stress concentrations, particularly in posterior regions, suggesting potential long-term mechanical limitations. Iliac grafts provided more favorable stress distribution and may be preferable for posterior implant rehabilitation.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102599"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apparent diffusion coefficient values of mandibular condyle bone marrow are associated with temporomandibular joint pain","authors":"Hiroshi Yamamoto ,&nbsp;Hirotaka Muraoka ,&nbsp;Yukiko Iizuka ,&nbsp;Eri Sawada ,&nbsp;Takashi Kaneda ,&nbsp;Hirotaka Oomine","doi":"10.1016/j.jormas.2025.102635","DOIUrl":"10.1016/j.jormas.2025.102635","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to measure the association between apparent diffusion coefficient (ADC) and temporomandibular joint (TMJ) pain.</div></div><div><h3>Materials and Methods</h3><div>This retrospective study included patients with suspected TMJ disorders who underwent magnetic resonance imaging. Primary predictor variables included the ADC value. Other predictor variables included the presence of joint effusion (JE), disc displacement, and mandibular condyle deformity. The outcome variable was the presence or absence of TMJ pain. Data were analyzed using binomial logistic regression, with statistical significance set at <em>P</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>The participant comprised 93 patients with a mean age of 47.42 ± 16.17 years; 80.65 % were female. The mean ADC value of mandibular condylar bone marrow was 0.83 ± 0.16 (× 10^–3mm²/<em>s</em> ± SD) in the group with joint pain and 0.74 ± 0.18 (× 10^–3mm²/<em>s</em> ± SD) in the group without pain. A statistically significant association was observed between the ADC value and TMJ pain (odds ratio (OR) = 13.0; 95% confidence interval (CI) = 1.52, 110.94; <em>P</em> = 0.02). No significant associations were found between TMJ pain and JE (<em>P</em> = 0.26), articular disc displacement (<em>P</em> = 0.23) or deformities (<em>P</em> = 0.08). The cutoff value for predicting the presence or absence of pain was 1.23 × 10^–3 mm²/s.</div></div><div><h3>Conclusions</h3><div>This study demonstrated the efficacy of diffusion-weighted imaging (DWI) for TMJ pain assessment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102635"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of orthodontic forces on masseter muscle morphology and function: A CBCT and electromyographic study","authors":"Pascal Ubuzima ,&nbsp;Quancheng Han ,&nbsp;Yuhe Cheng ,&nbsp;Lulu Hu ,&nbsp;Tingting Wu","doi":"10.1016/j.jormas.2025.102615","DOIUrl":"10.1016/j.jormas.2025.102615","url":null,"abstract":"<div><h3>Background</h3><div>Orthodontic treatment is important in restoring facial balance and harmony. The morphology and function of masticatory muscles influence facial aesthetics. This study aimed to assess the morphological and functional adaptation of masseter muscle during orthodontic treatment.</div></div><div><h3>Methods</h3><div>Two hundred and seventy-six fixed orthodontic patients aged 8–42 years were included and grouped into teenagers and adults. Pretreatment (T0) and three-month post-bonding (T1) masseter muscle morphology and function were assessed using Cone-Beam Computed Tomography (CBCT) and Electromyography (EMG). Assessments were performed at rest, maximum clenching and chewing. Independent <em>t</em>-test and Mann-Whitney U test were used for comparisons. Statistical significance was set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Morphologically, CBCT data showed no initial gender-based differences at T0. At T1, adult males exhibited a significant increase in masseter muscle length (MML), whereas adult females showed a notable reduction in masseter muscle thickness (MMT) and masseter muscle cross-sectional area (MMCA) on both sides. Teen females displayed a significant MMCA reduction (left). Functionally, mandibular postural position (MPP) and maximum voluntary bite position (MVBP) at the right side showed significant differences in adult patients at T0. In adult females, significant changes were observed in MPP (left) and masticatory movement (MM) (both sides), while adult males exhibited significant differences in MPP (left), MVBP (both sides), and MM (both sides). No significant functional differences were noted between orthodontic teenagers and adults as revealed by EMG data.</div></div><div><h3>Conclusion</h3><div>Altered masseter muscle activities and reductions in apparent dimensions, particularly in the female patients appeared within three months of orthodontic fixed treatment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102615"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivector gracilis muscle transfer for smile reanimation in long-standing facial paralysis: Simultaneous upper and lower lip construction","authors":"Pingping Liu,&nbsp;Ning Ma,&nbsp;Yong Tang,&nbsp;Sen Chen,&nbsp;Yilong Guo,&nbsp;Zhe Yang,&nbsp;Yangqun Li","doi":"10.1016/j.jormas.2025.102658","DOIUrl":"10.1016/j.jormas.2025.102658","url":null,"abstract":"<div><h3>Background</h3><div>Traditional facial reanimation with gracilis muscle transfer effectively restores oral commissure excursion but often fails to correct lower lip asymmetry, resulting in compromised full-dental smiles and perioral dysfunction. This study evaluated a multivector gracilis transfer designed to simultaneously reanimate both the upper and lower lips.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 29 patients with long-standing unilateral facial paralysis who underwent multivector gracilis free muscle transfer between 2020 and 2024. The gracilis was tailored into a forked configuration, with slips anchored to the oral commissure, upper lip, and lower lip. Objective outcomes were quantified using Emotrics software. Smile symmetry and muscle function were evaluated with the Terzis and Noah grading scale. Patient-reported quality of life was assessed using the Facial Clinimetric Evaluation (FaCE) scale.</div></div><div><h3>Results</h3><div>The mean follow-up was 1.76 ± 0.95 years. All patients demonstrated significant improvements in perioral symmetry at rest and during both closed- and open-mouth smiling. The dental show asymmetry between affected and unaffected sides was significantly reduced. The mean Terzis and Noah score increased from 1.07 ± 0.26 to 3.83 ± 0.60, and overall FaCE scores improved from 41.7 (IQR 34.6–48.8) to 61.7 (IQR 57.5–70.4). Complications included one hematoma and three flap bulkiness</div></div><div><h3>Conclusion</h3><div>This multivector forked gracilis design enables one-stage reanimation of both the upper and lower lips, improving functional and aesthetic outcomes in dynamic smile restoration.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102658"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish validity and reliability study of Temporomandibular Disorders-7 (TMD-7) scale","authors":"Umit Erkut ,&nbsp;Abdurrahim Yıldız","doi":"10.1016/j.jormas.2025.102597","DOIUrl":"10.1016/j.jormas.2025.102597","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to perform the cross-cultural adaptation and validation of the Turkish version of the Temporomandibular Disorders-7 (TMD-7) scale as a brief and reliable screening tool for temporomandibular disorder (TMD) symptoms.</div></div><div><h3>Methods</h3><div>Eighty participants (18–40 years) with temporomandibular joint (TMJ) pain or crepitus were included. The TMD-7 scale was translated and culturally adapted following international guidelines. Participants completed both the TMD-7 and the validated Turkish version of the Mandibular Functional Impairment Questionnaire (MFIQ) to assess criterion validity. Internal consistency was evaluated using Cronbach’s alpha, test-retest reliability with the Intraclass Correlation Coefficient (ICC), and criterion validity through Spearman’s correlation. Construct validity was tested using simple linear regression.</div></div><div><h3>Results</h3><div>The Turkish TMD-7 scale demonstrated excellent internal consistency (Cronbach’s α=0.985, <em>p</em> &lt; 0.001) and high test-retest reliability (ICC=0.985, 95 % CI: 0.97–0.99, <em>p</em> &lt; 0.001). Moderate positive correlations with MFIQ scores at both assessments (<em>r</em> = 0.577 and <em>r</em> = 0.559, <em>p</em> &lt; 0.001) supported criterion validity. Regression analyses confirmed that TMD-7 scores significantly predicted MFIQ outcomes (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The Turkish TMD-7 is a valid, reliable, and time-efficient instrument for assessing TMD-related pain and functional limitations. Due to its brevity and ease of administration, the TMD-7 is highly suitable for both clinical practice and research settings.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102597"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BUB1 and CCNB2 mediate cell cycle and inflammation, influencing the progression of oral squamous cell carcinoma","authors":"Wei Han ,&nbsp;Sumei Wang ,&nbsp;Haoyang Gao ,&nbsp;Bowen Du","doi":"10.1016/j.jormas.2025.102630","DOIUrl":"10.1016/j.jormas.2025.102630","url":null,"abstract":"<div><h3>Aims</h3><div>Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. Although the molecular mechanisms of OSCC have been explored, they remain incompletely understood. This study aimed to comprehensively analyze key molecular pathways involved in the occurrence and progression of OSCC, with the goal of identifying novel biomarkers for early diagnosis and potential therapeutic targets to improve patient prognosis.</div></div><div><h3>Methods</h3><div>OSCC datasets (GSE31056 and GSE51010) were obtained from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analysis, weighted gene co-expression network analysis (WGCNA), and protein-protein interaction (PPI) network analysis to predict core genes. Immune infiltration analysis was performed to estimate immune cell proportions. The Comparative Toxicogenomics Database (CTD) was used to identify diseases associated with the core genes. Real-time quantitative polymerase chain reaction (RT-qPCR) was conducted to validate the expression levels of core genes and related proteins.</div></div><div><h3>Results</h3><div>A total of 1017 DEGs were identified, which were mainly enriched in metabolic pathways, as well as the p53 and PPAR signaling pathways. Integration of three algorithms identified four central genes: BUB1, CCNB2, KIF23, and NEK2. Among them, BUB1 and CCNB2 were significantly overexpressed in OSCC compared with normal tissue samples. CTD analysis linked these genes to oral tumors, inflammation, and immune system diseases. Immune infiltration analysis revealed a higher proportion of neutrophils in OSCC samples. RT-qPCR confirmed elevated expression of BUB1, CCNB2, KIF23, NEK2, BAX, and Caspase-3 in OSCC.</div></div><div><h3>Conclusion</h3><div>Overexpression of BUB1 and CCNB2 may enhance cell cycle activity and inflammatory responses, thereby promoting OSCC cell proliferation.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102630"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene amplification and protein overexpression of FLNA in head and neck squamous cell carcinoma","authors":"Arundhathi Gnanashanmugam ,&nbsp;Jayalakshmi Somasundaram ,&nbsp;Paramasivam Arumugam","doi":"10.1016/j.jormas.2025.102609","DOIUrl":"10.1016/j.jormas.2025.102609","url":null,"abstract":"<div><h3>Objective</h3><div>Head and neck squamous cell carcinoma (HNSCC) is a common cancer with several risk factors. Filamin A (FLNA), an actin-binding protein, plays a role in cytoskeletal remodeling and tumor progression; however, its specific role in HNSCC is still unclear. In this study, we aimed to examine the amplification of the FLNA gene, along with its mRNA and protein overexpression, and evaluate their clinical significance in patients with HNSCC using multi-omics datasets and independent validation.</div></div><div><h3>Methods</h3><div>Genetic alterations in the <em>FLNA</em> gene were investigated using the cBioPortal, and the expression profiles were analyzed in UALCAN by integrating TCGA and CPTAC datasets. The expression of FLNA was validated in HNSCC and adjacent non-tumor tissue samples through real-time PCR; protein levels were determined from immunohistochemical data of the Human Protein Atlas. The Kaplan-Meier plotter was used for the prognostic analysis of HNSCC patients with <em>FLNA</em> expression. Furthermore, protein interaction networks were constructed using the Human Protein Atlas, followed by functional enrichment analysis <em>via</em> Metascape.</div></div><div><h3>Results</h3><div>FLNA was altered in 7 % of HNSCC patients, primarily through FLNA amplification, which was linked to increased mRNA expression (<em>p</em> &lt; 0.001). Moreover, FLNA mRNA and protein were significantly expressed in HNSCC tissues compared to non-tumor tissue samples (<em>p</em> &lt; 0.001). High FLNA expression was associated with advanced clinical stages, high histological grades, lymph node metastasis, and shorter overall survival (<em>p</em> &lt; 0.01). From the protein-protein interaction network, FLNA was central to pathways involved in focal adhesion, cell adhesion, and extracellular matrix interaction. These pathways are strongly associated with cancer development and progression.</div></div><div><h3>Conclusion</h3><div>These findings suggest that amplification and overexpression of FLNA could serve as a potential prognostic biomarker in HNSCC.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102609"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate genomic analysis elucidates the genetic architecture of shared components of burning mouth syndrome","authors":"Qiwu Lian ,&nbsp;Linsheng Dong ,&nbsp;Qiaoyu Zhou ,&nbsp;Qian Yuan","doi":"10.1016/j.jormas.2025.102605","DOIUrl":"10.1016/j.jormas.2025.102605","url":null,"abstract":"<div><h3>Background</h3><div>Burning mouth syndrome (BMS) is a chronic oral pain condition with unclear etiology. We sought to delineate the shared genetic architecture underlying BMS by modeling a latent BMS factor from multiple related traits.</div></div><div><h3>Methods</h3><div>We analyzed summary statistics from six published GWASs of BMS-related phenotypes (Sjögren’s syndrome, anxiety, depression, fibromyalgia, migraine, and dysphagia) using genomic structural equation modeling (genomic SEM) to construct an indirectly measured, multivariate GWAS for a latent BMS factor. We applied LDSC for genetic correlation and genomic control, FUMA/MAGMA for locus- and gene-level mapping, FINEMAP and SuSiE for fine-mapping, and performed transcriptome-wide association studies (TWAS) with FUSION followed by fine-mapping with FOCUS. We further conducted pathway and cell-type enrichment, and evaluated chromosome-level polygenic risk burden using PRS-CS.</div></div><div><h3>Results</h3><div>The common-factor genomic SEM showed good model fit and revealed substantial shared genetic covariance among the six traits. We identified nine genome-wide significant loci for the latent BMS factor. Fine-mapping highlighted credible variants at loci including MRPL49P1 and R3HDML. TWAS prioritized genes such as STAC3 associated with higher BMS risk and LRP1 associated with lower BMS risk. Enrichment analyses implicated conserved and enhancer regions, and suggested neuronal and immune-related cellular contributions. PRS analyses indicated higher polygenic burden on chromosomes 1 and 2.</div></div><div><h3>Conclusions</h3><div>Leveraging genomic SEM on six BMS-related GWASs, we provide a comprehensive, multiscale map of BMS genetic architecture, identifying nine significant loci and prioritizing candidate genes and pathways with potential pathophysiological relevance. These results nominate testable targets for functional follow-up and may inform future treatment strategies for BMS.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102605"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}