{"title":"Evaluation of stromal mucin expression in oral submucous fibrosis and its progression to oral squamous cell carcinoma","authors":"Sujitha A , Pratibha Ramani , Suvarna K Nair","doi":"10.1016/j.jormas.2025.102408","DOIUrl":"10.1016/j.jormas.2025.102408","url":null,"abstract":"<div><h3>Introduction</h3><div><span><span>Oral potentially malignant conditions (OPMDs) are abnormalities in the oral mucosa linked to a higher chance of developing oral cancer. Oral submucous </span>fibrosis<span> (OSMF) is a chronic condition causing tissue fibrosis, collagen deposition, and scar tissue production. The highest prevalence of OSMF is reported in Southeast Asian countries, with </span></span>areca nut consumption being a significant factor.</div></div><div><h3>Materials and methods</h3><div><span>This retrospective study involved 20 histopathologically confirmed cases: 10 of oral submucous fibrosis (OSMF) and 10 of oral squamous cell carcinoma<span> (OSCC) arising in the background of OSMF. Alcian blue staining was used to evaluate stromal mucin expression. The Pearson Chi-Square test assessed the relationship between mucin expression and </span></span>disease progression.</div></div><div><h3>Results</h3><div>A progressive increase in mucin expression was observed in OSMF-OSCC cases compared to OSMF. Alcian Blue staining revealed 35 % no expression and 15 % low expression in OSMF, while 35 % had low expression and 15 % had moderate expression in OSMF-OSCC cases. The chi-square test yielded a value of 13.3 (df = 2), with a corrected p-value of 0.003, indicating statistical significance.</div></div><div><h3>Conclusion</h3><div>Alcian Blue staining suggests a trend of increasing mucin expression during malignant transformation<span>. While not a definitive malignancy marker, it may serve as a useful adjunct in histopathological grading. Further studies with larger cohorts and standardized mucin quantification are recommended.</span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102408"},"PeriodicalIF":2.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Balercia , Giulio Cirignaco , Paolo Balercia
{"title":"Minimally invasive surgically assisted miniscrew anchored rapid palatal expansion (sa-MARPE) technique: avoiding conventional horizontal maxillary osteotomies – a technical note","authors":"Andrea Balercia , Giulio Cirignaco , Paolo Balercia","doi":"10.1016/j.jormas.2025.102415","DOIUrl":"10.1016/j.jormas.2025.102415","url":null,"abstract":"<div><div><span>In skeletally mature patients, transverse maxillary deficiency poses a significant challenge due to the rigidity of craniofacial sutures. This technical note describes a minimally invasive, surgically assisted MARPE (sa-MARPE) protocol designed to overcome these limitations while avoiding complete Le Fort I </span>osteotomies<span>. The technique involves three small mucosal incisions<span> and limited piezosurgical osteotomies targeting the midpalatal suture, canine pillars, and pterygomaxillary junctions. By preserving mucosal integrity and vascular supply, this approach reduces postoperative morbidity and enhances recovery. A case involving a 35-year-old woman treated with this protocol using a bone-borne expander (HIMAME) demonstrated stable skeletal expansion and crossbite correction at a 3-year follow-up, with no complications or relapse. This method offers predictable skeletal outcomes with minimal dentoalveolar side effects, making it a viable outpatient alternative to conventional SARPE in adults. Further studies are warranted to validate long-term stability and to compare outcomes with other assisted expansion techniques.</span></span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102415"},"PeriodicalIF":2.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of MARPE in adolescent maxillary expansion: Suture correlation and clinical outcomes","authors":"Wei Li , Fengxian Li , Zhuo Yu","doi":"10.1016/j.jormas.2025.102403","DOIUrl":"10.1016/j.jormas.2025.102403","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this paper was to explore the correlation between anchorage screw-assisted expansion and the maxillary suture in the treatment of adolescents with rapid maxillary expansion (RME) using miniscrew anchorage.</div></div><div><h3>Materials and methods</h3><div><span>A total of 60 adolescent patients with narrow maxillary arches, treated in the orthodontic department of our hospital from March 2021 to September 2022 and who underwent implant-assisted rapid maxillary expansion technology, were recruited for this study. The patients were divided into two groups: the control group (</span><em>n</em> = 30), who received traditional expansion technology, and the observation group (<em>n</em><span> = 30), who received Micro-Screw Anchorage Rapid Maxillary Expansion (MARPE) technology. The general data of the patients were collected, and cone beam computed tomography (CBCT) was used to measure the buccal maxillary width, palatal maxillary width, midpalatal suture expansion, maxillary skeletal expander expansion, and molar angle before and after treatment.</span></div></div><div><h3>Results</h3><div>Before treatment, there were no significant differences in maxillary width (buccal and palatal) or tooth angle between the two groups (<em>P</em> > 0.05). After treatment, the observation group showed a significantly greater increase in maxillary width (both buccal and palatal) and a more significant reduction in tooth angle compared to the control group (<em>P</em> < 0.05). The observation group also had a greater amount of bone expansion (<em>P</em><span> < 0.05), though alveolar bone bending was similar between groups (</span><em>P</em> > 0.05). The observation group had a higher effective rate and lower ineffective rate (<em>P</em> < 0.05), with no significant difference in adverse reactions (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Compared with the traditional expansion technique, the MARPE technique using anchorage nails as a fixed fulcrum can more effectively achieve maxillary expansion. By precisely controlling the application of expansion forces, MARPE promotes uniform expansion of the maxillary suture, improving the stability and predictability of the treatment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102403"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuhan Wang , Miao Yu , Pin Lv , Ruoyuan Li , Xiang Wu , Yaping Wu
{"title":"Identification of a novel signature derived from ferroptosis-related genes to predict prognosis, immune landscape and chemotherapeutic sensitivity in head and neck squamous cell carcinoma","authors":"Yuhan Wang , Miao Yu , Pin Lv , Ruoyuan Li , Xiang Wu , Yaping Wu","doi":"10.1016/j.jormas.2025.102392","DOIUrl":"10.1016/j.jormas.2025.102392","url":null,"abstract":"<div><h3>Background</h3><div>Ferroptosis<span><span><span> resistance is increasingly appreciated as an indispensable factor for tumor initiation, progression, and therapeutic resistance in various human </span>malignancies including </span>head and neck squamous cell carcinoma (HNSCC). Herein, we sought to develop a novel signature utilizing ferroptosis-related genes (FRGs) for prognosis and therapeutic prediction in HNSCC.</span></div></div><div><h3>Methods</h3><div>A prognostic signature<span><span> specific to HNSCC was developed using univariate Cox regression and LASSO-penalized multivariate Cox regression analyses. A nomogram incorporating this signature and selected clinicopathological factors was created through multivariate Cox regression. The effectiveness of the FRG signature in predicting </span>tumor mutation burden (TMB), immune status, and responses to chemotherapy was also evaluated.</span></div></div><div><h3>Results</h3><div><span><span>The FRG signature based on eight genes (AURKA, LPIN1, MIOX, </span>CDKN2A, PRKAA2, CISD2, TRIB3, and ASNS) successfully classified patients into subgroups with distinct outcomes across multiple cohorts. A FRG nomogram was constructed with good</span><strong>-</strong><span>prognostic performance. Additionally, higher FRG signature scores were positively associated with TMB and negatively correlated with tumor-infiltrating immune cells, which were linked to sensitivity to several chemotherapeutic drugs.</span></div></div><div><h3>Conclusions</h3><div>Our findings provide strong evidence that the FRG-derived signature/nomogram can effectively predict both prognosis and therapeutic response in HNSCC.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102392"},"PeriodicalIF":2.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuğba Haliloğlu Özkan , Büşra Gül Yılmaz , Sinan Altun
{"title":"Optimizing the Anatomical Location and Procedural Parameters for Miniscrew Placement in the Infrazygomatic Region- A CBCT Study","authors":"Tuğba Haliloğlu Özkan , Büşra Gül Yılmaz , Sinan Altun","doi":"10.1016/j.jormas.2025.102390","DOIUrl":"10.1016/j.jormas.2025.102390","url":null,"abstract":"<div><div><span>This study evaluates the integration of anatomical and procedural guidelines to develop realistic protocols for successful miniscrew insertion in the infrazygomatic crest (IZC) region, using CBCT measurements. A total of 720 measurements were collected from 30 adult patients, focusing on the upper first molar (U6) region. A grid system was created in the sagittal plane, including 12 reference points around the U6, with horizontal and vertical measurement points. A 12-mm virtual IZC miniscrew was inserted at each reference point, with the angle adjusted for 1 mm of sinus penetration and 5 mm of projection beyond the bone surface. Insertion success was defined as maintaining a minimum 0.5 mm safe distance from the roots, classified as system-compatible (SC), while root contact (RC), failure to achieve sinus penetration (SF), or sinus perforation (SP) exceeding 1 mm were classified as failures. No significant differences were found among the reference regions (</span><em>p</em><span> > 0.05). The 15 mm-U6MB region, with an insertion angle of 41.22°±8.67° apically and 12.36°±2.48° mesially, had the highest success rate of 55.0 %. The 15 mm-U6DB region, while aligning with the guidelines, had a higher incidence of root proximity (56.9 %). At the 17 mm region, sinus perforations exceeded 1 mm in 96.8 % of cases. The recommended placement height of 15 mm above the POP<span>, with a 40° apical and 10° mesial angle at U6MB, offers the best balance of stability and safety, in line with literature guidelines. This study provides clinicians with evidence for effective miniscrew placement, ensuring stability while avoiding critical anatomical structures.</span></span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102390"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anterior mandibular distraction osteogenesis: a retrospective study of condylar stability in the treatment of mandibular retrognathia secondary to idiopathic condylar resorption","authors":"Mengdie Chen , Yangyang Lin , Jiangfei Chen , Qi Xu , Yuanfu Hou , Zhiling Zhang , Bailing Yuan , Min Hou","doi":"10.1016/j.jormas.2025.102391","DOIUrl":"10.1016/j.jormas.2025.102391","url":null,"abstract":"<div><h3>Introduction</h3><div><span>The etiology of idiopathic condylar resorption (ICR) is not conclusively established, and its treatment is primarily focused on correcting secondary maxillofacial deformities. Condylar resorption is a common complication of the treatment of ICR. As one treatment for mandibular retrognathia<span> secondary to idiopathic condylar resorption (MRSICR), distraction osteogenesis (DO) can improve the facial profile and the occlusion. However, it has not been accurately determined whether DO could cause damage to the condyle. In this experiment, one innovative therapeutic modality was used to treat MRSICR by changing the traction device from the traditional posterior position of the mandibular body to the </span></span>premolar<span> region to explore a treatment method with less impact on the temporomandibular joint area (TMJ).</span></div></div><div><h3>Materials and methods</h3><div>A total of 11 patients (22 condyles) were included. To simulate the direction of traction, preoperative digital design was performed. Patients' radiological data were collected preoperatively (T0), six months following surgery (T1), a year following surgery (T2), and three years following surgery (T3). The changes in the distance of the TMJ space and in the surface area, volume, condylar plane angle, and condylar height at different intervals were assessed.</div></div><div><h3>Results</h3><div>Surface area, volume, height and the distances of anterior and posterior joint spaces of the condyle did not alter significantly after surgery (<em>P</em> > 0.05). Significant differences were found in the postoperative changes in supra-joint space and the condylar displacement in cross-section (<em>P</em> < 0.05).</div></div><div><h3>Discussion</h3><div><span>Our study suggests that as a treatment for MRSICR, the DO of the anterior mandible has shown some advantages in avoiding </span>postoperative complications as condylar resorption. Larger sample sizes are required for future research to validate the viability of this technique.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102391"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adalet Çelebi, Dilan Aykanat, Ayşe Özcan Küçük, Fethi Atil
{"title":"Survey on complications of Orthognathic surgery among oral and maxillofacial surgeons","authors":"Adalet Çelebi, Dilan Aykanat, Ayşe Özcan Küçük, Fethi Atil","doi":"10.1016/j.jormas.2025.102387","DOIUrl":"10.1016/j.jormas.2025.102387","url":null,"abstract":"<div><div><span><span>The purpose of this study is to investigate the rates of complications encountered by oral and maxillofacial surgeons<span><span> who actively perform orthognathic surgeries in Türkiye intraoperative and </span>postoperative periods. Sixty oral and maxillofacial surgeons, 39 male and 21 female, who actively performed orthognathic surgeries in Türkiye were included in this cross-sectional study which was conducted with a survey. A 19-item survey form was created and sent to the participants via the Google Forms platform. The survey included questions about complications in sagittal split ramus </span></span>osteotomy<span>, vertical ramus osteotomy, subapical osteotomy, genioplasty, LeFort 1 osteotomy, and bimaxillary surgery. In the interpretations of the results of the statistical analyses, </span></span><em>p</em><span><span><span> < 0.05 was accepted as the threshold for statistical significance. It was found that 46.7 % of the participants had 1–5 years of orthognathic surgery experience. The most frequently experienced complication in orthognathic surgeries of the mandible was nerve damage. Nerve damage was also the most frequently experienced complication in </span>sagittal split ramus osteotomy and bimaxillary surgery procedures, observed at rates of 82.5 % and 76.8 %, respectively. Condylar resorption, which is complication rarely encountered in the postoperative period, was encountered by 14 participants. The rate of participants with LeFort 1 osteotomy experience was 98.3 %, and the most frequently seen complication in this type of surgery was bleeding at a rate of 69 %. According to the results of this study, oral and maxillofacial surgeons in Türkiye encountered similar complications in orthognathic surgeries. Despite cases of severe complications during and after surgeries of the </span>maxilla and mandible, the low number of these complications makes orthognathic surgeries safe procedures.</span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102387"},"PeriodicalIF":2.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Constantijn Bogaert , Uri Singfer , Lisa De Kock , Peter Vanlangenhove , Renaat Coopman
{"title":"Pseudoaneurysm of the facial artery following mandibular bilateral sagittal split osteotomy: A case report","authors":"Constantijn Bogaert , Uri Singfer , Lisa De Kock , Peter Vanlangenhove , Renaat Coopman","doi":"10.1016/j.jormas.2025.102385","DOIUrl":"10.1016/j.jormas.2025.102385","url":null,"abstract":"<div><div><span><span>This article presents a case involving a 16-year-old female patient in whom a pseudoaneurysm of a </span>facial artery<span><span><span><span> branch was diagnosed two weeks after initial orthognathic surgery. The patient presented with a sensation of pressure, accompanied by pulsations synchronised with her heartbeat, located on the right side of the </span>mandible<span>. Ultrasound imaging, followed by </span></span>CT angiography, confirmed the diagnosis of a pseudoaneurysm within the </span>parotid region. Endovascular </span></span>embolization effectively stopped blood flow to the pseudoaneurysm, leading to rapid recovery without any lasting complications. A pseudoaneurysm is a rare complication following orthognathic surgery. This complication, as a result of anatomical variation, can have serious consequences if not recognised and treated in time.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102385"},"PeriodicalIF":2.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antley-Bixler syndrome: a case report on virtual planning for monobloc distraction osteogenesis and a surgical intervention narrative review","authors":"Namkabir Singh , Kalpana Selvaraju , Muhammad Kamil Hassan , Dharmendra Ganesan , Firdaus Hariri","doi":"10.1016/j.jormas.2025.102382","DOIUrl":"10.1016/j.jormas.2025.102382","url":null,"abstract":"<div><h3>Background</h3><div><span><span>Antley-Bixler syndrome (ABS) is an extremely rare genetic disorder characterized by distinct features such as trapezoidal face craniosynostosis, </span>midface hypoplasia with </span>exorbitism<span><span>, depressed nasal bridge, chonal atresia<span>, radio-humeral synostosis, </span></span>joint contractures<span> and arachnodactyly.</span></span></div></div><div><h3>Objective</h3><div>The aim of our study is to: (i) Comprehensively analyse available literature on ABS and report on the surgical management as well as treatment outcomes. (ii) Describe a case of ABS that has been successfully treated with monobloc distraction osteogenesis via virtual surgical planning.</div></div><div><h3>Methods</h3><div><span>A PUBMED search was performed in June 2024. The search was based on a general search string limited to “Antley-Bixler”. Inclusion criteria included systematic reviews preferably with meta-analysis, </span>randomized controlled trials<span>, cohort studies and case reports that were reported in English.</span></div></div><div><h3>Results</h3><div>Papers that focussed on surgical techniques were only present in the form of case reports and case series, out of which only 8 papers that fulfilled the inclusion criteria were included. Surgical techniques that were reported on included fronto-orbital advancement, midfacial advancement, distraction osteogenesis and others. The reported patients also underwent several other surgical procedures for either functional or aesthetic purposes. All the patients reported a good outcome from their surgical interventions.</div></div><div><h3>Conclusion</h3><div>Monobloc distraction osteogenesis is one of the most reliable and predictable procedures that may solve various problems associated with complex craniofacial deformities such as in ABS. This can be seen from the favourable outcome reported in several studies. However, comprehensive pre-surgical virtual planning and multidisciplinary care contributes greatly to favourable functional outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102382"},"PeriodicalIF":2.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}