{"title":"Efficacy of Propranolol and Pingyangmycin combination therapy in infantile hemangiomas: Correlation with VEGF levels","authors":"Jing Zhou , Chunling Gong , Yu Zhang","doi":"10.1016/j.jormas.2024.102176","DOIUrl":"10.1016/j.jormas.2024.102176","url":null,"abstract":"<div><h3>Background</h3><div>Infantile hemangiomas (IH) represent the most prevalent vascular tumors in infants, often necessitating prompt medical intervention due to their potential for rapid growth and complications. This retrospective study aims to evaluate the efficacy of propranolol combined with Pingyangmycin in the treatment of IH and to investigate its correlation with vascular endothelial growth factor (VEGF) levels.</div></div><div><h3>Methods</h3><div>A prospective, observational study was conducted over 12 months, enrolling 120 IH patients. Patients received a combination therapy of propranolol and pingyangmycin for 3 to 6 months. Hemangioma Activity Score (HAS) and serum VEGF levels were assessed at baseline, 30th day, and 90th day post-treatment.</div></div><div><h3>Results</h3><div>A total of 120 patients diagnosed with IH, including 68 males and 52 females with a mean age of 1.2 years, were enrolled in this study. The HAS at baseline was 8.5 ± 1.7, which significantly decreased to 4.2 ± 1.0 by Day 30 and further reduced to 2.1 ± 0.8 by Day 90 (<em>P</em> < 0.001 for both comparisons). Serum VEGF levels also showed a significant reduction from a baseline of 235.6 ± 42.1 pg/mL to 180.3 ± 34.7 pg/mL at Day 30 and to 122.8 ± 28.9 pg/mL at Day 90 (<em>P</em> = 0.02 and <em>P</em> = 0.01, respectively). The correlation analysis revealed a positive correlation between VEGF levels and HAS scores at all time points, with Pearson correlation coefficients ranging from -0.82 to -0.89 (<em>P</em> < 0.001). Adverse events were mild and transient, occurring in 15 % of patients, with the most common being mild hypoglycemia (8 %), transient bronchospasm (5 %), and gastrointestinal discomfort (2 %). All adverse events resolved with symptomatic treatment, and no patient discontinued therapy due to adverse reactions.</div></div><div><h3>Conclusion</h3><div>Propranolol treatment for infants with proliferative hemangiomas is significantly effective with minor adverse effects. The mechanism of action may be associated with the downregulation of serum VEGF levels.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102176"},"PeriodicalIF":1.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Innovative scientific illustration training for surgery residents in Paris","authors":"V. Sounthakith, R. Fawaz, R.H. Khonsari","doi":"10.1016/j.jormas.2024.102178","DOIUrl":"10.1016/j.jormas.2024.102178","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102178"},"PeriodicalIF":1.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Difference in survival and prognosis between malignant tumors of odontogenic origin","authors":"Quentin Hennocq , William Pouillot , Chloé Bertolus , Jean-Philippe Foy","doi":"10.1016/j.jormas.2024.102179","DOIUrl":"10.1016/j.jormas.2024.102179","url":null,"abstract":"<div><h3>Introduction</h3><div>The prognosis of metastatic ameloblastoma (METAM), now defined as a benign tumor, and malignant odontogenic tumors (MOT) is poorly studied in the literature. The aim of this study was to determine the prognosis and factors influencing the survival of these patients.</div></div><div><h3>Material and methods</h3><div>Using the SEER database, we retrieved clinical data of patients with malignant tumors of dental origin between 1975 and 2020. They include 3 histological groups: metastatic ameloblastoma (METAM), malignant odontogenic tumors (MOT, including odontogenic carcinoma, odontogenic sarcoma, primary intraosseous carcinoma, and ameloblastic carcinoma) and ameloblastic fibrosarcoma (AFS).</div></div><div><h3>Results</h3><div>On 251 patients, we observed no significant difference in disease-specific survival (DSS) between the three histological groups, with 5-year DSS of 77.4 % (59.9 – 100), 84.0 % (78.7 – 89.7) and 71.1 % (50.7 – 99.7) for METAM, MOT and AFS respectively (<em>p</em> = 0.460). In the MOT group, using a multivariate analysis, surgical treatment appeared to be a protective factor for DSS (HR = 0.483 [0.243 - 0.960], <em>p</em> = 0.038) after taking into account the potential confounding factors mentioned above. No variable significantly influenced DSS in the METAM and AFS group in univariate analysis.</div></div><div><h3>Discussion</h3><div>We found no difference in specific survival between the three histological groups. Although metastatic ameloblastoma was reclassified as a benign tumor by the WHO in 2017, the vital risk for patients remains consequent, and statistically similar to malignant odontogenic tumors.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102179"},"PeriodicalIF":1.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survival outcomes of surgically treated oral cavity squamous cell carcinoma patients at tertiary care hospital in Northern Thailand","authors":"Tapanut Ariyanon, Hanpon Klibngern, Pichit Sittitrai, Donyarat Ruenmarkkaew, Weerachai Watcharatsiriyuth","doi":"10.1016/j.jormas.2024.102166","DOIUrl":"10.1016/j.jormas.2024.102166","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the survival outcomes of surgically treated oral squamous cell carcinoma (OSCC) patients with or without adjuvant therapies and factors predicting treatment outcomes from the largest head and neck cancer center in Northern Thailand.</div></div><div><h3>Methods</h3><div>Two hundred and sixty OSCC patients curatively treated between 2017 and 2021 were retrospectively recruited into the study to analyze the clinicopathological characteristics and oncological outcomes and compare them with historical data. A multivariate Cox proportional hazards model analysis was performed to evaluate factors affecting survival outcomes.</div></div><div><h3>Results</h3><div>Males were slightly predominant (58.1 %). The most common subsite was an oral tongue (48.5 %), followed by an alveolar ridge (18.5 %). Advanced stages (III-IV) presented most at 88.5 %. The majority of the patients (52.3 %) received surgery and chemoradiotherapy, followed by surgery and radiotherapy (36.9 %), and surgery alone (10.8 %). The five-year overall survival (OS), disease-specific survival, and disease-free survival were 28.8 %, 44.0 %, and 46.3 %, respectively. Age > 45, ECOG performance status 2, and positive surgical margin status were found to be independent predictors for decreased OS (aHR 1.74, 95 % CI 1.01–3.00, aHR 2.64, 95 % CI 1.22–5.68, and aHR 1.76, 95 % CI 1.18–2.63, respectively).</div></div><div><h3>Conclusions</h3><div>Survival outcomes of OSCC in the study remain poor compared to other studies. The high prevalence of locally advanced stage presentation and inadequate surgical margin are the main problems. Public awareness, cancer screening programs, and intraoperative specimen-driven evaluation might help obtain adequate surgical margins and improve survival outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102166"},"PeriodicalIF":1.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Abdallah, Omar Hamdy, Islam H Metwally, Ahmed Setit, Shadi Awny
{"title":"Recurrent pleomorphic adenoma: Epidemiology and surgical challenges; a single tertiary center experience","authors":"Ahmed Abdallah, Omar Hamdy, Islam H Metwally, Ahmed Setit, Shadi Awny","doi":"10.1016/j.jormas.2024.102164","DOIUrl":"10.1016/j.jormas.2024.102164","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite being less common in recent years, recurrent pleomorphic adenoma still poses a surgical challenge, especially after improper surgery.</div></div><div><h3>Methods</h3><div>We retrospectively recruited all patients with recurrent pleomorphic adenoma and Carcinoma ex pleomorphic adenoma from February 2007 to April 2024 who were operated upon in a tertiary cancer center. Epidemiological, radiological, and pathological data, risk factors, details of surgical treatment, and surgical/oncological outcomes were analyzed.</div></div><div><h3>Results</h3><div>35 patients with recurrent pleomorphic adenoma were recruited, 19 were women (54.3 %) with the parotid gland being the most affected site in 74.3 % followed by the submandibular gland in 20 %. Only 11 patients (31.4 %) underwent surgery for the primary tumor in our center, and of interest that 48.6 % of the total cohort underwent simple enucleation for their primary tumors. The interval between resection and recurrence was shortened with frequent recurrences. Again, 71.4 % of facial nerve injuries had a history of simple enucleation for their primaries. 3 cases of Carcinoma ex pleomorphic adenoma were reported, representing 1.4 % of the patients with parotid pleomorphic adenoma in the study period, and was associated with young age and long-standing recurrence.</div></div><div><h3>Conclusions</h3><div>Surgery is the cornerstone treatment for both primary and recurrent pleomorphic adenoma. Inadequate primary surgery, long-standing lesions, multiplicity, and fragmentation may be associated with facial nerve injury. Reconstructive flaps may be needed to cover the large resultant defects. Surgery for pleomorphic adenoma should be done by adequately trained surgeons. Radiation as an adjuvant treatment needs to be used frequently, especially through a multidisciplinary approach. Carcinoma ex pleomorphic adenoma, being rare, is demanding in its management with a poor prognosis.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102164"},"PeriodicalIF":1.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of dimensional changes of the nasolacrimal canal after rapid maxillary expansion: A cone-beam computed tomography study","authors":"Ozge Muftuoglu Guler , Elif Meltem Aslan Ozturk","doi":"10.1016/j.jormas.2024.102160","DOIUrl":"10.1016/j.jormas.2024.102160","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to evaluate the nasolacrimal canal dimensionally and volumetrically after treatment in patients who underwent rapid maxillary expansion.</div></div><div><h3>Materials and methods</h3><div>A total of 19 patients (12 females, 7 males) with maxillary transverse deficiency, who underwent rapid maxillary expansion were included in the study. Cone beam computed tomography images were analyzed to measure the volume, anteroposterior diameter, transverse diameter, length, and angle of the nasolacrimal duct before and after treatment.</div></div><div><h3>Results</h3><div>The average age of the patients was 13.8 ± 1.69 years. Statistically significant increases in the volume, anteroposterior diameter, transverse diameter, length, and angle of the nasolacrimal canal were observed after treatment for both the right and left sides. No significant difference was found nasolacrimal canal dimensionally and volumetrically except angle on the left and right side of male and female patients. No significant differences were found in the changes between male and female patients.</div></div><div><h3>Conclusion</h3><div>Rapid maxillary expansion resulted in significant dimensional and volumetric increases in the nasolacrimal canal. Although no prior studies have linked maxillary transverse deficiency to nasolacrimal canal obstruction, the findings suggest that RME may be a viable treatment for nasolacrimal canal obstruction under appropriate conditions.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102160"},"PeriodicalIF":1.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evangelos N. Vitkos , Nefeli Eleni Kounatidou , Christos Tsilivigkos , Konstantinos Kotzagiorgis , Athanassios Kyrgidis , Lars Bonitz , Ákos Bicsák , Stefan Haßfeld , Christian Soemmer
{"title":"Restoring form and function: The role of free dermal fat graft (FDFG) in post-parotidectomy reconstruction. A systematic review and meta-analysis of expected outcomes and patient satisfaction","authors":"Evangelos N. Vitkos , Nefeli Eleni Kounatidou , Christos Tsilivigkos , Konstantinos Kotzagiorgis , Athanassios Kyrgidis , Lars Bonitz , Ákos Bicsák , Stefan Haßfeld , Christian Soemmer","doi":"10.1016/j.jormas.2024.102162","DOIUrl":"10.1016/j.jormas.2024.102162","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to assess the outcomes of free dermal fat graft (FDFG) reconstruction following parotidectomy, evaluating both clinical complications and patient satisfaction with the procedure.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis according to PRISMA guidelines, searching MEDLINE (via PubMed), Scopus, and the Cochrane Library for studies reporting on FDFG outcomes post-parotidectomy. Eligible studies included single-arm studies with data on recipient and donor site complications as well as patient satisfaction. Pooled complication rates were analyzed using a random-effects model to account for study heterogeneity.</div></div><div><h3>Results</h3><div>A total of 20 studies, representing 922 reconstructions in 919 patients, were included in the analysis. The overall rates of recipient site complications were low, with hematoma observed in 1.31% (95% CI: 0.50-3.34) and infection in 1.84% (95% CI: 0.95-3.53) of cases. The incidence of Frey's syndrome was 1.95% (95% CI: 0.74-5.02), and fat necrosis was noted in 1.74% (95% CI: 0.57-5.23) of patients. Donor site complications were minimal, with hematoma, infection, and seroma rates each below 1%. While there was high variability in satisfaction measures, results indicated favorable patient satisfaction with FDFG outcomes.</div></div><div><h3>Conclusion</h3><div>FDFG reconstruction following parotidectomy is a safe and effective method for correcting contour deformities, showing minimal complications and high patient satisfaction. The low incidence of complications, including Frey's syndrome, underscores FDFG as a viable option for facial contour restoration in parotid surgery, providing favorable aesthetic and functional outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102162"},"PeriodicalIF":1.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Astrid Richard , Serena Brontoladi , Estelle Sanquer , Cécile Chapuis-Vandenbogaerde , Alexandra Bucur , Valérie Charpillet , Véronique Soupre , Arnaud Picard , Natacha Kadlub
{"title":"Does the type of cleft have an impact on language results? Validation of the Nasalance test in French","authors":"Astrid Richard , Serena Brontoladi , Estelle Sanquer , Cécile Chapuis-Vandenbogaerde , Alexandra Bucur , Valérie Charpillet , Véronique Soupre , Arnaud Picard , Natacha Kadlub","doi":"10.1016/j.jormas.2024.102159","DOIUrl":"10.1016/j.jormas.2024.102159","url":null,"abstract":"<div><h3>Objectives</h3><div>The nasometer is the most widely used tool for objective assessment of phonation in both research and clinical practice. French standards have been validated in cases of total cleft lip and palate. The objective of this research is to propose a second validation study on velopalatal clefts. The 15 most sensitive and specific items from the initial validation were selected to create a test that is suitable for use in a clinical setting. A secondary objective is to ascertain the impact of cleft type on nasometry.</div></div><div><h3>Methods</h3><div>A total of 39 participants with an isolated or non-isolated velopalatal cleft were recruited for the study. A speech therapist conducted a blinded subjective evaluation of phonation. The nasometric assessment was based on a corpus developed in collaboration with the CNRS Phonetics and Phonology Laboratory. The corpus is composed of items that are phonetically balanced.</div></div><div><h3>Results</h3><div>The obtained nasalance threshold values ranged from 11 to 40%. The study corroborated the existence of a voicing effect, whereby the articulation of voiced consonants was associated with a higher nasalance score. This effect, not previously observed in other studies, is specific to French phonetics. Participants with a velopalatal cleft exhibited higher nasalance scores compared to those with a total cleft.</div></div><div><h3>Conclusion</h3><div>By validating the most relevant stimuli, a French Nasalance Test can be established. With a view to harmonising assessment protocols, it would be appropriate to use the items from this test in subjective assessment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102159"},"PeriodicalIF":1.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maxillary rehabilitation after zygomatic implant sequelae using custom subperiosteal implants: A case study","authors":"Frederico Rodger Gomes Rodrigues Cardoso , Ricardo Grillo","doi":"10.1016/j.jormas.2024.102154","DOIUrl":"10.1016/j.jormas.2024.102154","url":null,"abstract":"<div><div>Despite technological advancements, maxillary rehabilitation remains a significant challenge in Oral and Maxillofacial Surgery. This paper presents the case of a patient who underwent multiple previous procedures for prosthetic rehabilitation without achieving the desired results. The most recent intervention, which resulted in some sequelae, involved the placement of bilateral zygomatic implants. After unsuccessful attempts to maintain these implants, the decision was made to remove them and place a custom subperiosteal implant, produced via additive manufacturing. The patient has now been successfully rehabilitated with these implants for over a year, with no complaints and a notable improvement in her quality of life. The rehabilitation of severely atrophic maxillae using custom subperiosteal implants has proven to be an excellent alternative, offering predictability, the possibility of virtual planning and simulation, and the ability to rehabilitate extensive bone defects.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102154"},"PeriodicalIF":1.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}