Journal of Stomatology Oral and Maxillofacial Surgery最新文献

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Clinical effectiveness of 3D SPECT/CT imaging in determining osteotomy range for surgical treatment of medication-related osteonecrosis of the jaw: a retrospective study 三维SPECT/CT成像在确定药物相关性颌骨骨坏死手术治疗截骨范围中的临床效果:一项回顾性研究
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-15 DOI: 10.1016/j.jormas.2025.102375
Yubo Wei , Dongpo Li , Meng Wang , Congcong Wang , Xinfeng Liu , Yingying Zhang , Shuangyi Wang , Guoliang Li
{"title":"Clinical effectiveness of 3D SPECT/CT imaging in determining osteotomy range for surgical treatment of medication-related osteonecrosis of the jaw: a retrospective study","authors":"Yubo Wei ,&nbsp;Dongpo Li ,&nbsp;Meng Wang ,&nbsp;Congcong Wang ,&nbsp;Xinfeng Liu ,&nbsp;Yingying Zhang ,&nbsp;Shuangyi Wang ,&nbsp;Guoliang Li","doi":"10.1016/j.jormas.2025.102375","DOIUrl":"10.1016/j.jormas.2025.102375","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the clinical effectiveness of 3D SPECT/CT imaging in determining the osteotomy<span> range during surgical treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ) when combined with composite tissue flap techniques.</span></div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted involving 12 patients diagnosed with MRONJ. Each patient underwent a 3D SPECT/CT examination prior to surgery, where the region of interest (ROI) was outlined in the 3D images. During surgery, the affected bone was excised 0.5 cm beyond the delineated ROI. Various types of composite tissue flaps were utilized to close the defects based on their size and location.</div></div><div><h3>Results</h3><div>Patients were followed for an average of 7.9 months (range: 6–12 months), with all 12 achieving successful outcomes devoid of complications such as pyorrhea.</div></div><div><h3>Conclusion</h3><div>The utilization of 3D SPECT/CT enhances the precision of determining the osteotomy range in MRONJ surgeries. Coupled with composite tissue flap techniques for defect closure, this approach yields favorable clinical outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102375"},"PeriodicalIF":2.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the oral microbiota, blood metabolome, and inflammatory proteins on oral cavity cancer: A bidirectional two-sample Mendelian randomization study and mediation analysis 口腔微生物群、血液代谢组和炎症蛋白对口腔癌的影响:双向双样本孟德尔随机研究和中介分析。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-15 DOI: 10.1016/j.jormas.2025.102372
Qiwu lian , Linsheng Dong , Qiaoyu Zhou , Qian Yuan
{"title":"Effect of the oral microbiota, blood metabolome, and inflammatory proteins on oral cavity cancer: A bidirectional two-sample Mendelian randomization study and mediation analysis","authors":"Qiwu lian ,&nbsp;Linsheng Dong ,&nbsp;Qiaoyu Zhou ,&nbsp;Qian Yuan","doi":"10.1016/j.jormas.2025.102372","DOIUrl":"10.1016/j.jormas.2025.102372","url":null,"abstract":"<div><h3>Objective</h3><div>Oral Cavity Cancer (OCC) pathogenesis is complex, extending beyond traditional risk factors. While observational studies link oral microbiome<span><span> dysbiosis, </span>metabolic disturbances, and inflammation to OCC, inherent confounding limits causal inference regarding the putative 'microbiome-metabolite-inflammation' axis in OCC. Establishing causality is crucial.</span></div></div><div><h3>Methods</h3><div><span>We employed a two-sample Mendelian randomization (MR) framework using large-scale </span>GWAS data to address this gap. We systematically evaluated causal effects of 43 oral microbial taxa, 1400 diverse circulating metabolites, and 91 inflammatory proteins on OCC risk. We performed univariable MR (UVMR) for direct effects, multivariable MR (MVMR) adjusting for interactions, and mediation MR dissecting causal pathways.</div></div><div><h3>Results</h3><div><span><span>UVMR identified protective effects for Clostridiales (OR = 0.89) and </span>Rothia sp. ASV0016 (OR = 0.91), and increased risk for </span>Bacteroidales (OR = 1.09). Furthermore, 60 metabolites (e.g., glycohyocholate increasing risk; 16α-hydroxy DHEAS-3-sulfate decreasing risk) and two proteins (Cystatin D increasing risk, OR = 1.26; MCP-1 decreasing risk, OR = 0.69) showed causal links to OCC. Crucially, mediation analyses indicated protective microbial effects were partially mediated via specific metabolites, including 5α-androstan-3α,17β-diol disulfate (Clostridiales) and carboxyethyl-GABA (Rothia sp.).</div></div><div><h3>Conclusions</h3><div>This study provides robust genetic<span> evidence supporting causal roles for specific oral microbes and metabolites in OCC etiology. It offers mechanistic insights into the 'oral microbiome-host metabolism' axis, providing a basis for novel microbiome/metabolite-based biomarkers for early detection and risk assessment, and identifying potential preventative or therapeutic targets.</span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102372"},"PeriodicalIF":2.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of two subperiosteal implant designs in total maxillectomy: A 3-D finite element analysis 两种骨膜下种植体设计在上颌全切除术中的比较:三维有限元分析。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-15 DOI: 10.1016/j.jormas.2025.102377
Ilgın ARI, Gülin Acar
{"title":"Comparison of two subperiosteal implant designs in total maxillectomy: A 3-D finite element analysis","authors":"Ilgın ARI,&nbsp;Gülin Acar","doi":"10.1016/j.jormas.2025.102377","DOIUrl":"10.1016/j.jormas.2025.102377","url":null,"abstract":"<div><h3>Objective</h3><div><span>This study aims to compare two different subperiosteal implant designs using three-dimensional </span>finite element analysis (FEA) and to investigate the load distribution on the prosthetic components and the surrounding bone.</div></div><div><h3>Material and Method</h3><div>This study was conducted using a 3D representation of a Class II fully resected maxillary bone, generated. Two treatment scenarios were developed: SC-1 featured a conventional subperiosteal design, and SC-2 applied a diagonal bar design in the zygomatic region. A total force of 450 Newtons in a vertical direction and 93 Newtons in an oblique force were applied to mimic mastication forces. The maximum and minimum principal stress values on bone and von Mises stress (VMs) values on implant components' were measured.</div></div><div><h3>Results</h3><div>The results showed that under vertical forces, the SC-2 design exhibited higher maximum stress (Pmax) values in the zygomaticomaxillary area. Under oblique forces, stress values were higher in SC-2 in both areas compared to SC-1. VMs values on the screws were lower in SC-1 under vertical forces, while under oblique forces, they were lower in SC-2.</div></div><div><h3>Conclusion</h3><div>The findings suggest that the SC-2 design did not provide significant advantages over the conventional subperiosteal implant design. Future studies should focus on enhancing the conventional design by incorporating support from different anatomical areas.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102377"},"PeriodicalIF":2.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Acellular dermal matrix simultaneous with implant placement: A systematic review and meta-analysis of clinical trials 脱细胞真皮基质同时植入的疗效:临床试验的系统回顾和荟萃分析。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-11 DOI: 10.1016/j.jormas.2025.102371
Malik Alkabazi , Nawel Ouakouak , Ebtesam Aldieb
{"title":"Efficacy of Acellular dermal matrix simultaneous with implant placement: A systematic review and meta-analysis of clinical trials","authors":"Malik Alkabazi ,&nbsp;Nawel Ouakouak ,&nbsp;Ebtesam Aldieb","doi":"10.1016/j.jormas.2025.102371","DOIUrl":"10.1016/j.jormas.2025.102371","url":null,"abstract":"<div><h3>Purpose</h3><div><span><span><span>The vertical soft tissue thickness over the implant is essential for long-term procedure success and for biological integration of the suprabony soft tissue component, consequently, development of alternatives to autogenous soft tissue grafts such as allogeneic and </span>xenogeneic grafts were needed. </span>Acellular dermal matrix<span> (ADM) is utilized to provide structural support for angiogenesis<span>, revascularization and tissue remodeling in </span></span></span>soft tissue augmentation<span><span>, recession, and increasing the keratinized tissue width. At this point, the aim of this systematic review was to evaluate the amount of soft tissue height (STH) gained after augmenting the ADM in combination with the </span>dental implants<span>. Methods: A systematic search was performed in five databases. The primary outcome measure was STH change. Secondary outcomes included marginal bone loss (MBL) and pocket probing depth (PPD) at implant sites. Results: Six studies, with 200 participants, and reported pre- and post-operative mean of vertical tissue thickness, MBL, and PPD around implants were included in the meta-analysis. The pooled mean difference (MD) of STH was 0.84 (95 % CI:0.28 to 1.39) with a p-value &lt; 0.0001. A total of three studies, reported MBL. The pooled MD of MBL around implants, comparing the mean change from baseline to 12 months. The random effect model revealed a MD of 0.07mm (95 % CI: -0.21 to 0.35 mm, p= 0.6325). Calculation of pooled MD of PPD at implant sites, comparing ADM groups to the control groups in three studies; the random effect model revealed a MD of -0.13mm (95 % CI: -0.47 to 0.22 mm, p= 0.4742).</span></span></div></div><div><h3>Conclusion</h3><div>While Acellular dermal matrix significantly improves vertical soft tissue thickness, it does not significantly impact marginal bone loss or pocket probing depth.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102371"},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic resonance neurography: Preoperative assessment of facial nerve invasion in malignant parotid gland tumors 磁共振神经造影:恶性腮腺肿瘤面神经侵犯的术前评估。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-10 DOI: 10.1016/j.jormas.2025.102329
Xiao Hu , Wei Wang , Yi-Wei Zhong , Pu-Gen An , Jie Zhang , Wen-Jie Wu
{"title":"Magnetic resonance neurography: Preoperative assessment of facial nerve invasion in malignant parotid gland tumors","authors":"Xiao Hu ,&nbsp;Wei Wang ,&nbsp;Yi-Wei Zhong ,&nbsp;Pu-Gen An ,&nbsp;Jie Zhang ,&nbsp;Wen-Jie Wu","doi":"10.1016/j.jormas.2025.102329","DOIUrl":"10.1016/j.jormas.2025.102329","url":null,"abstract":"<div><h3>Backgrounds</h3><div><span>Facial nerve invasion (FNI) in </span>parotid gland<span><span> malignancies significantly impacts treatment outcomes and prognosis. Accurate </span>preoperative assessment of FNI is crucial for surgical planning and tumor staging. Conventional imaging modalities often fail to visualize the facial nerve and assess FNI.</span></div></div><div><h3>Objects</h3><div>This study aims to evaluate the predictive efficacy of magnetic resonance neurography (MRN) in detecting FNI in parotid gland malignancies, with the goal of aiding tumor staging and treatment decision-making.</div></div><div><h3>Methods</h3><div>28 patients with parotid gland malignancies were included. MRN was utilized to visualize the intraparotid facial nerve and determine its relationship with the tumor. MRN results were then used to predict FNI and re-evaluate the clinical T stage. Surgical records were used for validation. Statistical analysis was performed using chi-square tests and net reclassification improvement (NRI).</div></div><div><h3>Results</h3><div>The display rates of the main trunk and other divisions (temporofacial and cervicofacial) of the intraparotid facial nerve were 100 %, 96.4 %, and 96.4 %, respectively. Twenty-three patients (82.1 %) matched the surgical findings (<em>P</em><span> &lt; 0.01). MRN-indicated infiltration performed better than facial paralysis in predicting FNI. Tumors of stage T4a were underestimated in 22.7 % of cases (</span><em>n</em> = 5), and evaluation of clinical T stage with MRN was superior to that without MRN (NRI &gt; 0, <em>Z</em> = 2.17, <em>P</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>MRN can provide valuable information for predicting FNI in parotid gland malignancies, thereby improving tumor staging and aiding treatment decision-making.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102329"},"PeriodicalIF":2.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A growing concern: Predatory submissions and publication spam 越来越令人担忧的是:掠夺性提交和出版物垃圾邮件
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-10 DOI: 10.1016/j.jormas.2025.102328
Poramate Pitak-Arnnop
{"title":"A growing concern: Predatory submissions and publication spam","authors":"Poramate Pitak-Arnnop","doi":"10.1016/j.jormas.2025.102328","DOIUrl":"10.1016/j.jormas.2025.102328","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102328"},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral stent for peri-implant soft tissue management on jaw reconstruction: A simple, fast, and predictable technique 口腔支架用于颌骨重建种植体周围软组织管理:一种简单、快速、可预测的技术。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-01 DOI: 10.1016/j.jormas.2025.102325
Chloé Mense , Emmanuelle Lasserre , Yassine Bouabid , Benjamin Pomes
{"title":"Oral stent for peri-implant soft tissue management on jaw reconstruction: A simple, fast, and predictable technique","authors":"Chloé Mense ,&nbsp;Emmanuelle Lasserre ,&nbsp;Yassine Bouabid ,&nbsp;Benjamin Pomes","doi":"10.1016/j.jormas.2025.102325","DOIUrl":"10.1016/j.jormas.2025.102325","url":null,"abstract":"<div><div>Maxillofacial defects from tumor ablative surgery often bring about masticatory dysfunction. Reconstruction with vascularized flaps and oral rehabilitation are often challenging. Whenever possible, dental implants can improve patients' quality of life and comfort but the shallowness or absence of the oral vestibule, the flaps’ position, volume and mobility, the nature of surrounding tissues do not always allow a fabrication of prostheses in satisfactory conditions. The use of an oral stent was proposed to control, guide healing and position tissue around implants according to prosthetic needs. This article introduces a technic to fabricate a custom oral stent which is interesting because simple, fast, predictable and inexpensive.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102325"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transconjunctival lower blepharoplasty with orbital fat repositioning versus fat grafting for tear trough deformity: A prospective, comparative and randomized study 经结膜下睑成形术联合眶脂肪复位与脂肪移植术治疗泪槽畸形:一项前瞻性、对比性和随机研究。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-01 DOI: 10.1016/j.jormas.2025.102320
Jingni Li , Ting Xie , Xintong Jiang , Minli Yang , Beilei Wang , Hengxin Liu
{"title":"Transconjunctival lower blepharoplasty with orbital fat repositioning versus fat grafting for tear trough deformity: A prospective, comparative and randomized study","authors":"Jingni Li ,&nbsp;Ting Xie ,&nbsp;Xintong Jiang ,&nbsp;Minli Yang ,&nbsp;Beilei Wang ,&nbsp;Hengxin Liu","doi":"10.1016/j.jormas.2025.102320","DOIUrl":"10.1016/j.jormas.2025.102320","url":null,"abstract":"<div><h3>Background</h3><div><span>Fat prolapse and tear trough deformity, indicative of lower eyelid aging, are increasingly prevalent in younger patients. Transconjunctival lower </span>blepharoplasty (TCLB) is a suitable treatment for this demographic; however, traditional techniques have limitations that affect their simplicity and effectiveness.</div></div><div><h3>Objective</h3><div>We conducted a prospective, randomized controlled trial to systematically compare the modified TCLB technique with traditional TCLB in two groups, with the aim of evaluating its therapeutic efficacy through direct methodological comparison.</div></div><div><h3>Method</h3><div>This study, conducted from August 2020 to August 2022, included 40 patients with lower eyelid fat prolapse and tear trough deformity, randomly assigned to either the experimental or control group. The experimental group underwent a modified TCLB technique, while the control group received traditional TCLB combined with orbital fat release. Postoperative outcomes were evaluated by comparing baseline data, surgical duration, changes in the vertical distance from the lowest point of the tear trough to the pupil, Barton tear trough classification, and the Global Aesthetic Improvement Scale(GAIS) between the two groups.</div></div><div><h3>Result</h3><div>Preoperative baseline data showed no significant differences between the two groups. However, the experimental group had a significantly shorter surgical duration. Post-treatment comparisons revealed superior maintenance of surgical outcomes in the experimental group compared to the control group.</div></div><div><h3>Conclusion</h3><div>This prospective, comparative, and randomized study demonstrates the favorable therapeutic effects of the modified TCLB technique.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102320"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dispersed bacterial cellulose (DBC) alone graft material and adding DBC or the boric acid-absorbed DBC to xenograft increases the new bone formation during rabbit maxillary sinus augmentation- a pilot study 分散细菌纤维素(DBC)单独移植物材料和添加DBC或硼酸吸收DBC的异种移植物增加新骨形成骨在兔上颌窦增强过程中的初步研究。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-28 DOI: 10.1016/j.jormas.2025.102321
Songül Cömert Kiliç , Murat Özdal , Nihat Kiliç , Onur Ceylan , Gönül Koç
{"title":"Dispersed bacterial cellulose (DBC) alone graft material and adding DBC or the boric acid-absorbed DBC to xenograft increases the new bone formation during rabbit maxillary sinus augmentation- a pilot study","authors":"Songül Cömert Kiliç ,&nbsp;Murat Özdal ,&nbsp;Nihat Kiliç ,&nbsp;Onur Ceylan ,&nbsp;Gönül Koç","doi":"10.1016/j.jormas.2025.102321","DOIUrl":"10.1016/j.jormas.2025.102321","url":null,"abstract":"<div><div><span><span>This study aimed to evaluate and compare the effects of bone grafting materials, including </span>xenograft<span><span><span> alone, DBC<span> alone, xenograft + DBC, xenograft + </span></span>boric acid<span>, and xenograft + boric acid-absorbed DBC, on the newly formed bone, the immune reactivity<span><span><span> score of osteoprotegerin (OPG) and Receptor Activator Nuclear Kappa-B Ligand (RANKL) and the OPG/RANKL ratio by histological, histomorphometric and immunohistochemical analysis in rabbit </span>maxillary sinus<span> augmentation (MSA) model. Fourteen maxillary sinuses of New Zealand albino rabbits were augmented. Five groups were formed: xenograft alone (group1), dispersed bacterial cellulose (DBC) alone (group2), xenograft + DBC (group3), xenograft + </span></span>boric acid<span> (group4), xenograft +boric acid-absorbed DBC (group5). Eight weeks later, the species were examined. SEM, XRD, and </span></span></span></span>FTIR analyses<span> were carried out for DBC and boric acid-absorbed DBC. Inter-group comparisons were carried out by using the Kruskal-Wallis test for the immune reactivity score of OPG and RANKL and the independent sample </span></span></span><em>t</em><span><span><span>-test for OPG/RANKL ratio. The highest newly formed bone was observed in groups 3 and 5, and the lowest was in group 1. The percentages of newly formed bone area from highest to lowest occurred at 43.3 %, 38.3 %, 33.3 %, 30 %, and 19.5 % in groups 5, 3, 4, 2, and 1, respectively. Increased expression of OPG and RANKL was observed around newly formed bone areas in all groups. The immune reactivity score of OPG and RANKL expression was highest in group 5 and lowest in group 1, with no significant difference between the groups. The OPG/RANKL ratio was 1 in all groups, except the ratio was &gt; 1 in only group 5, with no significant difference between the groups. The surface of DBC showed a well-organized, irregular, and interconnected porous structure. DBC found a biocompatible material. Boric acid-absorbed DBC produced a more remarkable and enlarged </span>pore structure than DBC alone. The findings of the present pilot study indicated that DBC alone can be used as a scaffold and it seems an innovative </span>bone graft<span> material to filling bone defect<span> areas that it caused enhanced bone regeneration during MSA. Moreover, adding DBC or boric acid-absorbed DBC to xenograft increased newly formed bone significantly.</span></span></span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 4","pages":"Article 102321"},"PeriodicalIF":2.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective study of morphological and functional analysis of mandibular reconstructions using iliac and fibular flaps 使用髂骨瓣和腓骨瓣重建下颌骨的形态和功能分析回顾性研究
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-26 DOI: 10.1016/j.jormas.2025.102322
Drissa Diarra , Jialiang Chen , Hao Lin , Bang Zeng , Qiwen Man , Weiwei Deng , Bushabu Fidele Nyimi , Tianfu Wu , Bing Liu
{"title":"Retrospective study of morphological and functional analysis of mandibular reconstructions using iliac and fibular flaps","authors":"Drissa Diarra ,&nbsp;Jialiang Chen ,&nbsp;Hao Lin ,&nbsp;Bang Zeng ,&nbsp;Qiwen Man ,&nbsp;Weiwei Deng ,&nbsp;Bushabu Fidele Nyimi ,&nbsp;Tianfu Wu ,&nbsp;Bing Liu","doi":"10.1016/j.jormas.2025.102322","DOIUrl":"10.1016/j.jormas.2025.102322","url":null,"abstract":"<div><h3>Objective</h3><div>This retrospective study aims to evaluate and compare the morphological and functional characteristics of mandibular reconstructions performed using iliac and fibular flaps to determine their respective effectiveness and identify the technique that offers the best patient outcomes.</div></div><div><h3>Methods</h3><div>Medical and imaging data were analysed from pre- and post-operative scans of 121 patients (84 with iliac flaps and 37 with fibular flaps). Mandibular reconstructions were assessed by comparing morphometric parameters (distances and angles) and symmetry between the affected and unaffected sides using Mimics software. The quality of life of patients was assessed using a modified version of the University of Washington Quality of Life Questionnaire (UW-QOL), version 4, which evaluates functional and psychosocial outcomes in head and neck cancer treatment</div></div><div><h3>Results</h3><div>The results show that the iliac group demonstrates significantly superior performance for distances D2 and D3 and for the CA angle on the unaffected side. In contrast, the fibular group shows no significant advantage in these parameters. Regarding symmetry, the iliac group achieves better results for distance D3, whereas the fibular group excels in angular measurements. Additionally, the iliac group maintains better stability for angle B. Regarding bone dimensions, the iliac flap better preserves alveolar base height (ABH) and width (ABW), providing more consistent and favorable outcomes than the fibular flap.No overall difference was observed between the two groups regarding quality of life (assessed using the UW-QOL questionnaire). However, specific variations were noted: the fibular group scores higher for pain, activity, and recreation, while the iliac group achieves better results in appearance and speech.</div></div><div><h3>Conclusion</h3><div>The iliac flaps are the preferred option for mandibular reconstruction, offering superior morphometric stability, better preservation of bone dimensions, and more robust structural consistency than fibular flaps. Although both techniques yield comparable overall quality-of-life results, iliac flaps demonstrate more pronounced clinical benefits, leading to optimal postoperative outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102322"},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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