Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Biomechanical analysis of teeth movement during the repair of mandibular defects using transport disk distraction osteogenesis","authors":"Yuzhuan Hou,&nbsp;Xuetong Zhang,&nbsp;Juan Wang,&nbsp;Liang Zhao","doi":"10.1016/j.jormas.2024.102147","DOIUrl":"10.1016/j.jormas.2024.102147","url":null,"abstract":"<div><h3>Introduction</h3><div>Teeth movement or rotation is one of the complications of mandibular defect repair using transport disk distraction osteogenesis (TDDO). However, the mechanical reasons are not clearly understood.</div></div><div><h3>Material and methods</h3><div>To evaluate the biomechanical factors associated with teeth movements during mandibular defect repair with TDDO, a finite element model created from computed tomographic images of the human mandible was adopted to evaluate teeth displacement and the Von Mises stress distribution on the periodontal ligament resulting from the transport disk for teeth subjected to TDDO loading.</div></div><div><h3>Results</h3><div>Under a displacement of 0.5 mm to the fixed arm of the transport disk, the teeth on the disk moved away from the distraction. The stress on the periodontal ligament was highest (60 KPa) around the distal neck. Upon the application of 150 g of resistance, the entire tooth moved in the same direction and the isoline gradient was almost parallel to the long axis of the tooth. Although the stress was distributed similarly; it decreased to 0.117 KPa geometrically.</div></div><div><h3>Discussion</h3><div>When mandibular defects are repaired with TDDO, the transport disk and anti-distraction forces contribute to the reversal movement or rotation of the teeth, which may become immobility when antagonistic forces are applied in the same direction.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102147"},"PeriodicalIF":1.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is autoimmunity associated with the development of premalignant oral conditions and the progression to oral squamous cell carcinoma?: A literature review","authors":"Jeong-Hyun Kang ,&nbsp;Seok Woo Hong","doi":"10.1016/j.jormas.2024.102139","DOIUrl":"10.1016/j.jormas.2024.102139","url":null,"abstract":"<div><h3>Objective</h3><div>Oral potentially malignant disorders (OPMDs) are oral mucosal conditions that may progress to oral squamous cell carcinoma (OSCC). Although autoimmunity has linked to the malignant transformation potential of various precancerous conditions, its role in OPMD remains unclear. This review aimed to identify the role of systemic autoimmunity on OPMD development and their progression to OSCC.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted using PubMed, Cochrane CENTRAL, and SCOPUS database for articles published up to January 2024. The key questions addressed by this review were “Is autoimmunity associated with the development of OPMD” and “How does systemic autoimmunity influence the potential for malignant transformation of OPMD?”. This review followed the PRISMA guidelines for scoping reviews (PRISMA-ScR).</div></div><div><h3>Results</h3><div>Of the 1265 articles initially identified, 21 fulfilled the search criteria. Three themes were emerged; 1) the prevalence and prognosis of oral cancers in patients with systemic autoimmune diseases, 2) circulating autoantibodies in OPMD patients, and 3) autoimmune-related markers linked to malignant transformation in OPMD patients. This review indicated that systemic autoimmunity may contribute to chronic inflammatory conditions, disruption of oral mucosal integrity, and interference with the DNA damage repair process, thus influencing malignant transformation in the oral epithelium of patients with OPMD.</div></div><div><h3>Conclusion</h3><div>The co-occurrence of OPMD with circulating autoantibodies or systemic autoimmune diseases underscores the importance of understanding these interactions for improved management of OPMD and early detection of OSCC.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102139"},"PeriodicalIF":1.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatile sulfur compounds and salivary parameters in patients undergoing head and neck cancer treatment: A preliminary study","authors":"Juliana Maria Braga Sclauser ,&nbsp;Karolina Skarlet Silva Viana ,&nbsp;José Alcides Almeida de Arruda ,&nbsp;Alessandro Oliveira de Jesus ,&nbsp;Meiriane Cristina Faria Soares Lima ,&nbsp;Arnoldo Mafra ,&nbsp;Lucas Guimarães Abreu ,&nbsp;Patrícia Carlos Caldeira ,&nbsp;Ricardo Alves Mesquita ,&nbsp;Tânia Mara Pimenta Amaral","doi":"10.1016/j.jormas.2024.102158","DOIUrl":"10.1016/j.jormas.2024.102158","url":null,"abstract":"<div><h3>Background</h3><div>Treatment for head and neck squamous cell carcinoma (HNSCC) is often associated with various adverse effects, including changes in salivary parameters and complaints of halitosis. This study aimed to investigate changes in volatile sulfur compound (VSC) levels and salivary parameters in patients undergoing treatment for HNSCC.</div></div><div><h3>Methods</h3><div>This prospective longitudinal study was conducted at a Brazilian oncology center, where a convenience sample of 24 HNSCC patients undergoing radiotherapy or chemoradiotherapy were evaluated for VSC levels, salivary flow, pH, viscosity, dry mouth, and tongue coating. Assessments were performed at the beginning and end of antineoplastic therapy. VSC levels were measured using an Oral Chroma™ gas chromatograph. Data were analyzed descriptively and analytically.</div></div><div><h3>Results</h3><div>No significant changes were found in overall VSC levels. However, a statistically significant reduction in salivary flow (<em>p</em> &lt; 0.001) and pH (<em>p</em> = 0.017) and an increase in salivary viscosity (<em>p</em> = 0.037) were noted post-treatment. Patients who reported halitosis after treatment exhibited significantly higher hydrogen sulfide levels (<em>p</em> = 0.045). Tongue coating and VSC levels showed no significant changes.</div></div><div><h3>Conclusion</h3><div>Treatment for HNSCC results in reduced salivary flow, altered pH, and increased salivary viscosity. Although self-reported halitosis correlates with elevated hydrogen sulfide levels post-treatment, no significant changes in overall VSC concentrations were observed.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102158"},"PeriodicalIF":1.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An artificial intelligence mechanism for detecting cystic lesions on CBCT images using deep learning","authors":"Rasool Esmaeilyfard ,&nbsp;Nasim Esmaeeli ,&nbsp;Maryam Paknahad","doi":"10.1016/j.jormas.2024.102152","DOIUrl":"10.1016/j.jormas.2024.102152","url":null,"abstract":"<div><h3>Introduction</h3><div>The present study aimed to provide and evaluate the efficiency of an artificial intelligence mechanism for detecting cystic lesions on cone beam computed tomography (CBCT) scans.</div></div><div><h3>Method and materials</h3><div>The CBCT image dataset consisted of 150 samples, including 50 cases without lesions, 50 dentigerous cysts (DC), and 50 periapical cysts (PC) based on both radiographic and histopathological diagnosis. The dataset was divided into a development set with 70 % of samples for training and validation and a final test set with the other 30 % of samples. Four images were obtained for each case, including panoramic, manually segmented panoramic, axial, and manually segmented axial images. A deep convolutional neural network (CNN) architecture was used for automatic lesion detection and diagnosing the type of cystic lesion. To increase the number of image samples and avoid overfitting, a data augmentation procedure was applied. Recall, precision, F1-score, and average precision (AP) values were measured for lesion detection performance, and sensitivity, specificity, and accuracy indicators from the confusion matrix were calculated for the lesion classification performance of the CNN model.</div></div><div><h3>Results</h3><div>Mean average precision, recall, and F1-score for the detection of DCs and PCs were respectively, 0.87, 0.92, and 0.89 before data augmentation, and 0.93, 0.95, and 0.93, after the augmentation process. For the classification of DCs with data augmentation, sensitivity, specificity, accuracy, and AUC values were 96.4 %, 99.5 %, 97.3 %, and 0.98, respectively, and for PCs with augmentation, these values were 89.6 %, 98.9 %, 98.1 %, and 0.94, respectively. Lastly, for no lesion samples, sensitivity, specificity, accuracy, and AUC values were 100 %, 99.1 %, 99.4 %, and 0.99, respectively, by application of data augmentation.</div></div><div><h3>Conclusion</h3><div>Our developed deep learning-based CNN algorithm showed high accuracy, sensitivity, and precision values (more than 90 %) for detecting and classifying dentigerous and periapical cysts on CBCT images using data augmentation.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102152"},"PeriodicalIF":1.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “SAPHO syndrome in the mandible: a 17-patient-based experience”","authors":"Jian Huang,&nbsp;Han Huang,&nbsp;Yi He,&nbsp;Shaobiao Pan,&nbsp;Jing Wang,&nbsp;Xiaojun Shi,&nbsp;Zhenhua Ying,&nbsp;Chen Li","doi":"10.1016/j.jormas.2024.102142","DOIUrl":"10.1016/j.jormas.2024.102142","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102142"},"PeriodicalIF":1.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the biomechanical effects and stability of titanium and carbon fiber-reinforced polyetheretherketone mini plates in Le Fort I advancement osteotomy fixation using finite element analysis","authors":"Kübra Yakut,&nbsp;Sezai Çiftçi","doi":"10.1016/j.jormas.2024.102153","DOIUrl":"10.1016/j.jormas.2024.102153","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to investigate the biomechanical properties of 60 % carbon fiber-reinforced polyetheretherketone (Cfr-PEEK), which exhibits high mechanical strength and can address the limitations of titanium mini plates used in Le Fort I osteotomy.</div></div><div><h3>Material and Method</h3><div>Models were created using the FEA method based on tomography images of adult individuals. A 5 mm maxillary advancement was applied to the models following Le Fort I osteotomy. Mini plates made of titanium and 60 % Cfr-PEEK were used. Support was provided by the nasomaxillary and zygomaticomaxillary buttresses to fix a total of four l-shaped mini plates. Oblique loads of 125 N, directed from palatal to buccal, and a total of 250 N compression loads were applied to the central fossa of the premolar and molar teeth in the maxillary model at a 30° angle relative to the long axis of the teeth. Displacement values at the osteotomy line, Von Mises stresses in the mini plate-screws, and principal stresses in the bone were compared.</div></div><div><h3>Results</h3><div>Examination of stress values in the fixation systems of the models revealed higher stress values in the Cfr-PEEK model compared to the titanium model. However, these stresses did not reach levels that would deform the Cfr-PEEK fixation systems. Stress and displacement values in the bone were lower in the Cfr-PEEK model compared to the titanium model.</div></div><div><h3>Conclusion</h3><div>According to the findings of our study, Cfr-PEEK represents a viable alternative to titanium for mini plate material in Le Fort I osteotomy, offering biomechanical advantages.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102153"},"PeriodicalIF":1.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of zinc or copper supplementation on the efficacy and sustainability of botulinum toxin A “Botox” injection in masseter muscle of albino rats","authors":"Yasmin Saad Elgendy ,&nbsp;Sanaa Elzoghby ,&nbsp;Nermeen AbuBakr","doi":"10.1016/j.jormas.2024.102156","DOIUrl":"10.1016/j.jormas.2024.102156","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate whether oral zinc or copper supplementation affected the efficacy and sustainability of botulinum toxin-A (BTX-A) injection in masseter muscle of albino rats.</div></div><div><h3>Materials and methods</h3><div>32 adult male albino rats were allocated equally into four groups: group I (control), group II received 10U BTX-A injection, group III received 10U BTX-A injection + zinc (1 mg, 4 days pre-injection), and group IV received 10U BTX-A injection + copper (0.04 mg, 7 days post-injection). Rats were euthanized at 2 and 12 weeks (4 rats per subgroup) after injection. The masseter muscle was examined via histological, histochemical, histomorphometrical and real-time polymerase chain reaction (qRT-PCR) analyses.</div></div><div><h3>Results</h3><div>The histopathological results of the BTX-A group showed atrophied muscle fibers with increased atrophy with time compared to the control group. The BTX-A + zinc group displayed more atrophy compared to BTX-A group. Conversely, the BTX-A + copper group demonstrated improved histology of muscle fibers compared to BTX-A and BTX-A + zinc groups. Histomorphometric analysis of Masson trichrome staining at 2 and 12 weeks revealed that collagen area percentage was the highest in the BTX-A + copper and control groups, followed by BTX-A and BTX-A + zinc groups. At 12 weeks, the nuclear factor kappa beta (NF-κB) mRNA expression was significantly higher in BTX-A + zinc and BTX-A groups compared to BTX-A + copper group and relative to the control group.</div></div><div><h3>Conclusion</h3><div>Zinc supplementation significantly improved the effectiveness and durability of BTX-A, whereas copper supplementation reduced its efficacy.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102156"},"PeriodicalIF":1.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology and in vitro experiments reveal the potential therapeutic effects of Scrophularia ningpoensis Hemsl in the treatment of ameloblastoma","authors":"Jing-Rui Yi ,&nbsp;Bang Zeng ,&nbsp;Bing Liu ,&nbsp;Rui-Fang Li ,&nbsp;Yin-Fu Che ,&nbsp;Qi-Wen Man","doi":"10.1016/j.jormas.2024.102146","DOIUrl":"10.1016/j.jormas.2024.102146","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to explore active ingredients in Scrophularia ningpoensis Hemsl (SNH) with potential effects on ameloblastoma (AM) using network pharmacological approach, bioinformatic gene analysis and in vitro cell experiments.</div></div><div><h3>Methods</h3><div>The active ingredients and their corresponding targets of SNH were identified from the Traditional Chinese Medicine Systems Pharmacology (TCMSP), as well as SwissTargetPrediction. Disease targets of AM were selected from GeneCards and DisGeNET databases. Differentially expressed genes (DEGs) of AM were identified, and Gene Ontology enrichment analysis were performed using the Gene Expression Omnibus (GEO) dataset GSE38494 through bioinformatic analysis. The STRING database platform was utilized to generate a protein–protein interaction network diagram, followed by hub gene analysis using Cytoscape software. AutoDock Vina software was used to perform molecular docking verification of the effects of the active ingredients on potential core targets. Additionally, in vitro experiments including quantitative reverse transcription polymerase chain reaction (RT-qPCR), EdU assay and CCK-8 cell proliferation assay were conducted using AM cell line AM-1 after SNH extract treatment.</div></div><div><h3>Result</h3><div>The study revealed that SNH contains eight active ingredients and a total of 388 drug targets, including 10 potential core targets in AM. Hub genes identified in the analysis were <em>CCNA2, HRAS, PTGS2, PIK3CB, FGFR1, CASP3, MMP1, SLC2A1, MMP14</em>, and <em>MME</em>. Molecular docking analysis demonstrated strong binding activity between key active ingredients (β-sitosterol, scropolioside A_qt, scropolioside D, scropolioside D_qt, and sugiol) and target genes (<em>CASP3, FGFR1, HRAS, PTGS2</em>, and <em>SLC2A1</em>). Gene Ontology enrichment analysis indicated that SNH exerts its effects on AM through pathways related to cellular response to abiotic stimulus, cellular response to hypoxia, and exopeptidase activity. Immunohistochemical analysis using tissue microarray showed higher expression of MMP14 and PTGS2 in AM compared to dentigerous cyst. Using AM-1 cell line, RT-qPCR results confirmed that SNH suppressed the expression of <em>MMP14</em> and <em>PTGS2</em> at mRNA level. Additionally, the EdUassay and CCK-8 assay indicated the inhibitory effect of SNH on the proliferation of AM-1 cells.</div></div><div><h3>Conclusion</h3><div>These findings showed that SNH could suppress expression of <em>MMP14</em> and <em>PTGS2</em> and restrain the proliferation of AM. Our study highlights the potential of SNH as a promising therapeutic candidate for AM, which may provide more options for clinical treatment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102146"},"PeriodicalIF":1.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising titanium implant stability and infection resistance through iron nanoparticle coatings: A preclinical investigation","authors":"Santosh Nelogi ,&nbsp;Anand kumarpatil ,&nbsp;Ramesh Chowdhary ,&nbsp;Richa Roy","doi":"10.1016/j.jormas.2024.102155","DOIUrl":"10.1016/j.jormas.2024.102155","url":null,"abstract":"<div><h3>Background</h3><div>Attaining adequate osseointegration and mitigating infections are paramount issues in implantology, especially within dental and orthopaedic domains. Titanium implants have been utilised for their biocompatibility and mechanical strength; yet, problems such as peri‑implant infections and inadequate bone integration may undermine their efficacy. Coating titanium implants with iron nanoparticles (FeNp) has surfaced as a promising approach to improve osseointegration and antibacterial characteristics. FeNp's distinctive capacity to react to magnetic fields and produce reactive oxygen species (ROS) has the potential to enhance implant results.</div></div><div><h3>Objective</h3><div>To assess the influence of FeNp-coated titanium implants on osseointegration, mechanical stability, osteogenesis, and antibacterial effectiveness against prevalent implant-associated infections, Staphylococcus aureus and Escherichia coli.</div></div><div><h3>Materials and methods</h3><div>In vivo investigations were performed on animal models to evaluate implant stability by resonance frequency analysis (RFA) and removal torque measurements at 6 and 12 weeks post-implantation. Histopathological assessment was conducted to analyze the osseous formation and vascularization surrounding the implants. Furthermore, in vitro experiments were employed to assess the antibacterial efficacy of magnetized FeNp against S. aureus and E. coli.</div></div><div><h3>Results</h3><div>At 6 weeks, no substantial change was detected in (RFA) or removal torque between the control group (GROUP A) and the test group (GROUP B). However, by 12 weeks, GROUP B demonstrated significantly higher RFA scores (75.02 ± 5.11) compared to GROUP A (67.41 ± 9.85), indicating improved implant stability (<em>p</em> &lt; 0.05). Removal torque values were also significantly higher in GROUP B at 12 weeks (76.30 ± 14.20) compared to GROUP A (46.10 ± 9.25), suggesting enhanced mechanical integration (<em>p</em> &lt; 0.01). Histopathological analysis revealed greater new bone formation, increased osteoblast activity, and improved vascularization around FeNp-coated implants in GROUP B. Additionally, in vitro antibacterial testing demonstrated that FeNp coatings effectively inhibited the growth of Staphylococcus aureus and E. coli, providing further evidence of its antimicrobial effect</div></div><div><h3>Conclusion</h3><div>FeNp-coated implants have dual advantages: improved osseointegration and antibacterial defence. The findings indicate that FeNp coatings might substantially enhance implant longevity and diminish the likelihood of infection, offering a potential approach for clinical applications, especially for patients at elevated risk of implant failure. Subsequent research should concentrate on enhancing the application of FeNp coatings in clinical environments and further examining their long-term biocompatibility and effectiveness.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102155"},"PeriodicalIF":1.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysbiosis and interactions of the salivary bacteriome in obese individuals: A human cross-sectional study","authors":"Liang Beibei ,&nbsp;Jing Yuzi ,&nbsp;Yang Hengye ,&nbsp;Fan Yifan ,&nbsp;Lin Yanli ,&nbsp;Yang Dongru ,&nbsp;Zhao Chen ,&nbsp;Liu Qing","doi":"10.1016/j.jormas.2024.102131","DOIUrl":"10.1016/j.jormas.2024.102131","url":null,"abstract":"<div><h3>Introduction</h3><div>The prevalence of obesity is continually rising worldwide, posing a risk for the development of various serious diseases. The pathogenesis of obesity is complex and recent research suggests a link between obesity and the oral microbiome, though the specific mechanisms remain unclear.</div></div><div><h3>Material and methods</h3><div>We collected saliva samples from 9 non-obese and 13 obese participants and conducted 16S rRNA sequencing to analyze the differences in oral microbiota between obese and non-obese individuals in terms of microbial abundance, functionality, and interaction networks.</div></div><div><h3>Results</h3><div>Obese participants exhibited a distinct composition of salivary microbiota compared to non-obese participants, with a greater number of ASVs detected and higher α diversity indices. Specifically, <em>Haemophilus, Aggregatibacter</em>, and <em>Actinobacillus</em> were significantly enriched, while <em>Actinomyces</em> showed significant depletion. Functional prediction analysis indicated that biofilm formation pathways were significantly more abundant in the obese group. Random forest regression model analysis identified <em>Bergeyella</em> as the most contributive genus, and interaction network analysis suggested that <em>Bergeyella</em> may function as a bridge node, linking the obese group-enriched genera to the broader microbial community and facilitating the exchange of information and resources.</div></div><div><h3>Discussion</h3><div>Our study suggests that obesity may be closely associated with salivary microbiota dysbiosis and functional changes. Further research is needed to elucidate the causal relationship and underlying molecular mechanisms between obesity and oral microbiota dysbiosis, or to determine if they mutually influence each other.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102131"},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}