Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"CK7 and P63 as predictive markers for neoplastic transformation of dentigerous and glandular odontogenic cysts to mucoepidermoid carcinoma","authors":"Seham Ahmed Abdel Ghani ,&nbsp;Noha El-Sherif ,&nbsp;Sara A. Denewer","doi":"10.1016/j.jormas.2025.102600","DOIUrl":"10.1016/j.jormas.2025.102600","url":null,"abstract":"<div><h3>Aim</h3><div>The study aims to compare the expression of CK7 and p63 proteins in dentigerous cysts (DCs) and glandular odontogenic cysts (GOCs), evaluating their potential as predictors of neoplastic transformation into mucoepidermoid carcinoma (MEC). Additionally, it seeks to explore the possible roles of inflammation and mucous cell metaplasia in the malignant transformation of these cysts.</div></div><div><h3>Material and methods</h3><div>Sixty tissue blocks were divided into three groups with two subgroups each (10 cases). Diagnoses were confirmed using Hematoxylin and eosin (H&amp;E) staining, followed by immunohistochemical staining for CK7, p63, and mucicarmine</div></div><div><h3>Results</h3><div>The study revealed a significant difference in the expression of CK7, p63, and mucicarmine staining across the three groups (P-value ≤ 0.05). The GOCs group exhibited the highest mean values (15.21, 5.15, and 2.04, respectively), followed by the DCs group (5.18, 2.64, and 0.39, respectively), while the control group had the lowest mean values (1.68, 0.94, and 0.00, respectively). In the inflamed subgroups, the GOCs (19.70, 5.80, and 3.10, respectively), DCs (7.36, 3.51, and 0.58, respectively), and control groups (2.07, 1.22, and 0.00, respectively) showed higher mean values compared to their non-inflamed counterparts.</div></div><div><h3>Conclusion</h3><div>The expression of CK7, p63, and mucicarmine in DCs and GOCs provides key insights into their potential for malignant transformation into MEC. GOCs exhibit higher levels of CK7 and p63, indicating a greater risk of neoplastic progression compared to DCs. These markers help differentiate the cysts and assess their malignancy potential, with inflammation possibly playing a role in the transformation to MEC.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102600"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of various implant configurations for atrophic maxilla: A three-dimensional finite element analysis","authors":"Fatih Girgin,&nbsp;Onur Yilmaz","doi":"10.1016/j.jormas.2025.102608","DOIUrl":"10.1016/j.jormas.2025.102608","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate stress distributions in zygomatic, trans-sinus, and pterygoid implants and the surrounding atrophic maxillary alveolar bone using finite element analysis (FEA).</div></div><div><h3>Methods</h3><div>Three-dimensional (3D) FEA models with 10-mm conventional implants in the lateral incisor regions were designed. For posterior anchorage, 30° trans-sinus or 45° zygomatic implants (placed using the extrasinus technique) were positioned in the second premolar region, with or without 45° pterygoid implants in the second molar region. Accordingly, four models were created: (1) zygomatic, (2) zygomatic and pterygoid, (3) trans-sinus, and (4) trans-sinus and pterygoid implant. A titanium bar-supported polymethyl methacrylate prosthesis was designed for occlusal restoration. A force of 300 N was applied vertically and obliquely (at 20°) to each model.</div></div><div><h3>Results</h3><div>Oblique forces caused higher stress than vertical forces. Compared with trans-sinus implant models, zygomatic implant models exhibited lower stress under vertical loading (except in the premolar implants and cancellous bone) and oblique loading (except in the cancellous bone around the anterior implant). Adding pterygoid implants to those in the All-on-4 protocol (All-on-6 protocol) significantly reduced stresses on the bone and restoration, and the von Mises stress in the premolar implants decreasing by &gt;50 % in the pterygoid models.</div></div><div><h3>Conclusion</h3><div>The most ideal configuration for rehabilitation of the atrophic maxilla was Model 2 with zygomatic and pterygoid implants, but the stress values in Model 4, which used trans-sinus and pterygoid implants, were close to those in Model 2. Pterygoid implants can be considered a useful addition to All-on-4 or zygomatic implants.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102608"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An automated diagnostic support system for jaw pathologies on panoramic radiographs: a DenseNet121-CBAM deep learning study with histopathological correlation","authors":"Darpit K Brahmbhatt,&nbsp;Jigna S Shah","doi":"10.1016/j.jormas.2025.102604","DOIUrl":"10.1016/j.jormas.2025.102604","url":null,"abstract":"<div><h3>Objectives</h3><div>To develop and prospectively validate a novel deep learning model, integrating a DenseNet architecture with a Convolutional Block Attention Module (CBAM), for the automated classification of six common jaw pathologies from orthopantomogram (OPG) images.</div></div><div><h3>Methods</h3><div>A retrospective dataset of 236 histopathologically confirmed pathological OPGs (Ameloblastoma, Dentigerous Cyst, Odontogenic Keratocyst, Radicular Cyst, Squamous Cell Carcinoma, Osteomyelitis) and 5200 normal OPGs was used for model training and pre-training. The DenseNet121-CBAM model was trained using transfer learning, data augmentation, and a weighted sampler to address class imbalance. Performance was prospectively validated on an independent cohort of 228 cases, with histopathological diagnosis serving as the ground truth.</div></div><div><h3>Results</h3><div>On the prospective test set, the AI model achieved an overall accuracy of 92.54 % in classifying jaw pathologies against the histopathological gold standard. The model demonstrated robust class-specific performance, with F1-scores ranging from 90 % to 98 %.</div></div><div><h3>Conclusions</h3><div>The attention-augmented deep learning model provides a rapid and highly accurate method for diagnosing common jaw pathologies on OPGs. Its performance, validated against histopathology, establishes its potential as a reliable diagnostic support tool to enhance clinical workflows and aid in early pathology detection.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102604"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of fluoroscopy-guided sclerotherapy with foam polidocanol for retromolar trigon venous malformation: A case report and review of the literature","authors":"Razan Baabdullah","doi":"10.1016/j.jormas.2025.102610","DOIUrl":"10.1016/j.jormas.2025.102610","url":null,"abstract":"<div><div>Venous malformations (VMs) are vascular anomalies that can pose significant challenges in pediatric patients. This case report describes the successful treatment of a retromolar trigone VM in an eight-year-old child using a single injection of 3 % polidocanol foam using the Tessari technique and administered under fluoroscopic guidance. This resulted in significant reduction of the lesion and complete resolution of symptoms without complications. Follow-up evaluations were scheduled at two weeks, one month, three months, six months, and twelve months post-procedure. At six months post-procedure, there was no detectable lesion, though a minimal residual bluish discoloration persisted on the lingual surface. At twelve months, this discoloration remained unchanged, with no signs of recurrence. This case highlights the efficacy and safety of polidocanol foam sclerotherapy as a minimally invasive treatment option for pediatric maxillofacial VMs. Further studies are warranted to evaluate the long-term outcomes and broader applicability of this technique.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102610"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “War as a teacher: Experiences of facial reconstruction with anterolateral thigh flap during the Ukrainian war” [J Stomatol Oral Maxillofac Surg 126 (2025) 102407]","authors":"Bekir Osmanov ,&nbsp;Karri Mesimäki ,&nbsp;Tetiana Pavlychuk ,&nbsp;Tommy Wilkman ,&nbsp;Yurii Chepurnyi ,&nbsp;Johanna Snäll ,&nbsp;Andrii Kopchak","doi":"10.1016/j.jormas.2026.102720","DOIUrl":"10.1016/j.jormas.2026.102720","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102720"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated 3D Craniofacial Cephalometry in Orthognathic Surgery: A Preliminary Evaluation","authors":"Astrid Aisenfarb ,&nbsp;Arlette Oueiss ,&nbsp;Jacques Treil ,&nbsp;Emmanuel Chamorey ,&nbsp;Charles Savoldelli","doi":"10.1016/j.jormas.2025.102537","DOIUrl":"10.1016/j.jormas.2025.102537","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the efficiency and accuracy of an automated three-dimensional (3D) cephalometric software in diagnosing dento-skeletal dysmorphoses and its concordance with standard clinical diagnosis used in orthognathic surgery.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted at the Department of Otorhinolaryngology and Maxillofacial Surgery of the University Hospital of Nice. Fourteen patients who underwent bimaxillary surgery were included in this analysis. Standardized cephalometric and clinical diagnoses were compared with automated software-generated diagnoses. The statistical agreement between the two approaches was analyzed to assess the reliability of the software.</div></div><div><h3>Results</h3><div>The software demonstrated a great agreement with our standardized diagnosis and a high reproducibility rate for skeletal measurements. However, it displayed discrepancies in specific parameters, particularly in soft tissue assessments (lack of measurements) and occlusal characteristics.</div></div><div><h3>Conclusion</h3><div>Automated 3D cephalometry has significant potential as a diagnostic tool in orthognathic surgery. However, refinements are required to improve its accuracy, particularly in soft tissue assessment and occlusal analyses, before it can be fully integrated into routine clinical practice.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 1","pages":"Article 102537"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical study on the stability of mini-implants in the infrazygomatic crest region","authors":"Qian Lin ,&nbsp;Yanling Chen ,&nbsp;Tingxu Lin ,&nbsp;Fuhai Zhao","doi":"10.1016/j.jormas.2025.102623","DOIUrl":"10.1016/j.jormas.2025.102623","url":null,"abstract":"<div><h3>Objective</h3><div>To determine insertion angles and force directions that minimize micromotion of infrazygomatic crest (IZC) mini-implants while accounting for the curved lateral wall and the non-parallel bicortical anatomy.</div></div><div><h3>Methods</h3><div>We built 20 three-dimensional finite element models that preserved full thread geometry and the true IZC bicortical relationship. Two force directions (horizontal vs. vertical), five insertion angles (15°–70°), and single vs. double cortical engagement were tested under a 2 N load. Outcomes included implant displacement and von Mises stress in the screw and surrounding bone.</div></div><div><h3>Results</h3><div>Vertical loading consistently halved displacement compared with horizontal loading (mean 7.3 ± 2.9 μm vs. 14.7 ± 6.2 μm). Under horizontal forces, 45° minimized displacement (8.1 μm) and cortical stress (92 MPa); under vertical forces, 15° performed best (4.6 μm). Effect sizes were substantial: vertical vs. horizontal displacement ratio ≈ 0.50; 45° vs. 70° cortical stress reduction ≈ 33–40 % under horizontal loading. Penetrating the thin sinus floor (∼0.45 mm) did not improve stability.</div></div><div><h3>Conclusion</h3><div>For IZC anchorage, 15–45° insertion with predominantly vertical force reduces stress and micromotion; thin bicortical engagement provides no additional benefit. These anatomy-aware rules are readily applicable chairside.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 1","pages":"Article 102623"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinicopathological correlation of BRAF V600E mutations in ameloblastoma: A PCR study from a tertiary centre in South India","authors":"Logeswari Jayamani ,&nbsp;Kavitha Bottu ,&nbsp;Leena Dennis Joseph ,&nbsp;Ganthimathy Sekhar","doi":"10.1016/j.jormas.2025.102575","DOIUrl":"10.1016/j.jormas.2025.102575","url":null,"abstract":"<div><h3>Background</h3><div>Ameloblastoma is a locally aggressive, benign epithelial odontogenic tumor characterized by unpredictable biological behavior and a high recurrence rate. The recent WHO 5th edition classification (2022) has integrated key molecular advances, prominently featuring MAPK pathway mutations such as BRAF V600E. Understanding the prevalence with its clinicopathological associations with BRAF mutations is crucial for prognostication and targeted therapy planning.</div></div><div><h3>Objectives</h3><div>To determine the status of BRAF V600E mutation in ameloblastoma cases using quantitative real-time PCR and to correlate mutation status with demographic and clinicopathological parameters over a five-year period from a tertiary care centre.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted on 40 cases of histologically confirmed ameloblastoma and 5 samples of normal odontogenic epithelium (control), using archived formalin-fixed paraffin-embedded tissue. Genomic DNA was isolated and subjected to qRT-PCR for BRAF V600E mutation analysis. Associations with age, gender, site, recurrence, and histopathological type were evaluated using chi-square, Fisher’s exact, and Student’s t-tests.</div></div><div><h3>Results</h3><div>BRAF V600E mutations were detected in 28 of 40 ameloblastoma cases (70.0 %) and were absent in all control samples. Solid ameloblastoma demonstrated the highest mutation rate (87.5 %), followed by unicystic ameloblastoma (56.5 %), and adenomatoid ameloblastoma (100 %). No cases of peripheral or metastasizing ameloblastoma were observed.</div></div><div><h3>Conclusion</h3><div>BRAF V600E mutation is prevalent in ameloblastoma and varies across histopathological subtypes. Although statistical associations with clinicopathological features were limited, the mutation’s high frequency underscores its diagnostic and therapeutic significance in ameloblastoma, justifying routine screening as part of a personalized management approach.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 1","pages":"Article 102575"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledging our reviewers","authors":"","doi":"10.1016/S2468-7855(26)00021-2","DOIUrl":"10.1016/S2468-7855(26)00021-2","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 1","pages":"Article 102728"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of thyme honey mouth rinse on polypharmacy-induced xerostomia: A randomized controlled clinical trial with a biochemical assessment","authors":"Suzan S. Ibrahim ,&nbsp;Neven Nabil Tadry ,&nbsp;Ola M. Ezzatt ,&nbsp;Radwa R. Hussein","doi":"10.1016/j.jormas.2025.102641","DOIUrl":"10.1016/j.jormas.2025.102641","url":null,"abstract":"<div><h3>Background</h3><div>The global prevalence of systemic diseases and subsequent drug consumption, which is strongly associated with xerostomia, has become increasingly prominent. Considering the significance of maintaining good oral health and hypothesizing that natural salivary stimulants could serve as a safe and effective treatment option, we assessed the therapeutic efficiency of thyme honey mouthwash in treating individuals with polypharmacy-induced xerostomia.</div></div><div><h3>Methods</h3><div>A randomized controlled trial performed at Ain Shams University's Faculty of Dentistry, Egypt, on 64 patients consuming two or more xerostomia-inducing medications and complaining of dry mouth. Patients were randomly assigned to receive thyme honey oral rinse (Study Group) or normal saline oral rinse (Control Group) (3/day/4weeks). Unstimulated salivary flow rate (USFR), subjective (SDS), and clinical oral dryness scores (CODS) were evaluated at baseline and after 2 and 4 weeks. The salivary nitric oxide levels (SNO) and xerostomia-related quality of life scale (XeQoLS) were assessed at baseline and after 4 weeks.</div></div><div><h3>Results</h3><div>The USFR showed a notable increase (<em>P</em> &lt; 0.001) in the study group (161.82 ± 89.57 %) compared to the control group (17.11 ± 10.53 %) after 4 weeks, accompanied by an improvement in oral dryness scores. XeQoLS values showed significant improvement, and the SNO levels significantly decreased after using thyme honey mouth rinse for 4 weeks.</div></div><div><h3>Conclusion</h3><div>The study concluded that the thyme honey mouth rinse effectively increased the salivary secretion, decreased SNO levels and oral dryness scores, and improved the quality of life for patients experiencing polypharmacy-induced xerostomia.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 1","pages":"Article 102641"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}