Journal of Stomatology Oral and Maxillofacial Surgery最新文献

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IncobotulinumtoxinA in refractory temporomandibular disorder due to disk dislocation: A prospective study 椎间盘脱位引起的难治性颞下颌关节紊乱症的前瞻性研究。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101804
{"title":"IncobotulinumtoxinA in refractory temporomandibular disorder due to disk dislocation: A prospective study","authors":"","doi":"10.1016/j.jormas.2024.101804","DOIUrl":"10.1016/j.jormas.2024.101804","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Temporomandibular disorders (TMD) may include conditions involving the temporomandibular joint and/or </span>masticatory muscles<span>. Approximately 20 % of patients are refractory to first-line therapies. This study aims to evaluate the effects and safety of incobotulinumtoxinA in the treatment of refractory TMD due to disk dislocation.</span></p></div><div><h3>Material and methods</h3><p><span><span>A quasi-experimental one-arm prospective study was conducted. Target population included individuals with a diagnosis of TMD due to disk dislocation. Patients were treated with electromyography or ultrasound guided injection of </span>incobotulinumtoxinA in the masticatory muscles (20 U into each </span><em>masseter</em> and <em>pterygoideus lateralis</em><span><span><span>). Pain was assessed using the pain numerical rating scale, maximum unassisted mouth opening was measured in mm, and </span>adverse events were registered at baseline, week 4, week 12 and week 24 post-treatment. Statistical analysis used the </span>Wilcoxon test for the comparison of paired samples and the Mann-Whitney U test for independent samples, considering a p-value ≤ 0.05 as significant.</span></p></div><div><h3>Results</h3><p>51 patients with 75 painful temporomandibular joints due to disk dislocation (38 with reduction and 37 without) were included. A significant reduction in pain from a pre-treatment mean of 6.08/10 to a post-treatment mean of 2.04/10 (week 4), 3.18/10 (week 12), and 3.65/10 (week 24) was observed (<em>p</em> &lt; 0.001). A significant decrease in maximum unassisted mouth opening from a pre-treatment mean of 36.45 mm to a post-treatment mean of 32.29 mm at week 4 was observed (<em>p</em> &lt; 0.001).</p></div><div><h3>Discussion</h3><p>Botulinum toxin injection of the masticatory muscles is safe and seems equally effective in reducing pain in patients with refractory TMD due to disk dislocation.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101804"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of clinical impact of two types of Temporomandibular joint disc reduction and fixation 颞下颌关节椎间盘缩小和固定术
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101956
{"title":"Evaluation of clinical impact of two types of Temporomandibular joint disc reduction and fixation","authors":"","doi":"10.1016/j.jormas.2024.101956","DOIUrl":"10.1016/j.jormas.2024.101956","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the clinical effectiveness and stability of open suture versus micro-screw anchored disc reduction and fixation in treating disc displacement without reduction in the anterior temporomandibular joint.</p></div><div><h3>Methods</h3><p>A total of 38 patients (51 sides) with anterior disc displacement without reduction (ADDwR) of the TMJ treated in our hospital from August 2021 to January 2023 were selected, including 19 cases in group A (23 sides) treated with open temporomandibular joint disc<span> reduction and anchorage, and 19 cases in group B (28 sides) treated with temporomandibular joint disc reduction and suture. The Magnetic Resonance Imaging (MRI) data of the two groups before and after operation were compared to evaluate the effective rate of articular disc<span> reduction, the change of articular disc length, The Maximal Interincisal Opening (MIO) and Numeric Rating Scale (NRS) were measured before and after operation.</span></span></p></div><div><h3>Results</h3><p>In group A, the MRI effective rate 6 months after disc reduction was 95.65 % (22/23), the disc length gain was 1.74 mm, MIO was 40.32±5.067 mm, and NRS was 0.47±0.697. The MRI effective rate 6 months after disc reduction in group B was 100 % (28/28). The disc length gain was 1.78 mm, MIO was 41.58±3.746 mm, and NRS was 0.00. There was no significant difference between the two groups (<em>P</em> &gt; 0.05).</p></div><div><h3>Conclusions</h3><p>TMJ disc reduction and suture and open TMJ disc anchorage can effectively reduce the TMJ disc. The TMJ disc stability is high at 6 months after operation, and the pain and mouth opening can be improved, which is worthy of further promotion in clinical practice.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101956"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of an objective assessment tool for velopharyngeal insufficiency in cleft lip and palate children 验证唇腭裂儿童咽喉发育不全的客观评估工具。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101968
C. Fersing , D. Thevarajah , E. Sanquer , C. Chapuis , A. Amelot , C. Fougeron , L. Aljancic , A. Picard , N. Kadlub
{"title":"Validation of an objective assessment tool for velopharyngeal insufficiency in cleft lip and palate children","authors":"C. Fersing ,&nbsp;D. Thevarajah ,&nbsp;E. Sanquer ,&nbsp;C. Chapuis ,&nbsp;A. Amelot ,&nbsp;C. Fougeron ,&nbsp;L. Aljancic ,&nbsp;A. Picard ,&nbsp;N. Kadlub","doi":"10.1016/j.jormas.2024.101968","DOIUrl":"10.1016/j.jormas.2024.101968","url":null,"abstract":"<div><p>The objective of this study is to utilize the Nasometer to objectively assess velopharyngeal competence, specifically through the quantification of nasalance. Initial calibration of the nasometer was conducted on American adults. The objective of this study was to validate the use of the nasometer for the objective diagnosis of velopharyngeal insufficiency<span> (VPI) in French children born with a total cleft lip and palate<span> and to select relevant verbal stimuli for clinical practice.</span></span></p></div><div><h3>Material and methods</h3><p>The nasalance scores of 42 children aged 8 to 10 years old, born with a cleft lip and palate, were collected and compared with 50 control children. The scores were then analyzed in relation to 31 verbal stimuli from the French corpus created for this study (sentences and syllables). The most relevant threshold values were determined by receiver operating characteristic curves, which exhibited the highest sensitivity and specificity.</p></div><div><h3>Results</h3><p>The results demonstrated statistically significant differences (p &lt; 0.05) in the mean nasalance scores of the control and cleft groups for all verbal stimuli containing oral phonemes. Threshold values with good diagnostic accuracy were defined, and 15 verbal stimuli were selected for use in clinical practice.</p></div><div><h3>Conclusion</h3><p>The nasalance threshold values defined in this study can be utilized for the objective diagnosis of velopharyngeal insufficiency (VPI) and the subsequent monitoring of French children aged 8 to 10 years old, born with a cleft lip and palate.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101968"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between the articular disc in magnetic resonance imaging and the condyle in cone beam computed tomography: A retrospective study 磁共振成像中的关节盘与锥形束计算机断层扫描中的髁状突之间的关系:一项回顾性研究。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101940
{"title":"The relationship between the articular disc in magnetic resonance imaging and the condyle in cone beam computed tomography: A retrospective study","authors":"","doi":"10.1016/j.jormas.2024.101940","DOIUrl":"10.1016/j.jormas.2024.101940","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;&lt;span&gt;The authors retrospectively studied the relationship between the morphology and position of the articular disc in magnetic resonance imaging (MRI) and the morphology and position of the condyle in &lt;/span&gt;cone beam computed tomography (CBCT), with the purpose for providing reference for clinical diagnosis and treatment of temporomandibular disorders (TMD).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Patients with both CBCT and MRI imaging data were studied retrospectively, excluding TMJ&lt;span&gt; tumour, fracture, severe condylar morphological abnormalities, non-intercuspal position, and poor quality images. A total of 744 temporomandibular joints (TMJs) from 372 patients were included, with the mean age of 25.94±11.04Y (75 males and 297 females). T2-weighted image (T2WI) of MRI imagings were used to evaluate disc morphology and disc displacement, while CBCT was obtained to evaluate the condylar bone and sagittal condylar position. Data were analysed by Pearson Chi square test and Spearman correlation coefficient.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results: The distribution of 744 TMJs is as follows: 1) disc morphology&lt;/h3&gt;&lt;p&gt;contracture (37.1 %) &gt; biconcave (32.9 %) &gt; irregular (18.5 %) &gt; lengthened (11.4 %); 2) disc position: ADDWoR (48.3 %) &gt; NA (26.9 %) &gt; ADDWR (21.6 %) &gt; PDDWR (2.8 %) &gt; PDDWoR (0.4 %); 3) condylar position: concentric (43.7 %) &gt; posterior (37.6 %) &gt; anterior (18.7 %); 4) condylar bone: normal (63.4 %)&gt; abnormal (36.6 %). There were significant differences in the distribution of disc morphology and disc position between the sex (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). There were significant differences in the distribution of disc position and condylar morphology amongst the age groups (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). There were significant differences in the distribution of disc position, condylar position and condylar morphology amongst disc morphology (&lt;em&gt;P&lt;/em&gt; &lt; 0.05), and there were positive correlation between disc position(&lt;em&gt;r&lt;/em&gt; = 0.703, &lt;em&gt;P&lt;/em&gt; = 0.000), the score of condyle (&lt;em&gt;r&lt;/em&gt; = 0.478, &lt;em&gt;P&lt;/em&gt; = 0.000) and disc morphology respectively. There were significant differences in the distribution of disc position and condylar position amongst condylar morphology (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). There was a positive correlation between disc position and condyle morphology (&lt;em&gt;r&lt;/em&gt; = 0.413, &lt;em&gt;P&lt;/em&gt; = 0.000), and a negative correlation between condyle position and condyle morphology (&lt;em&gt;r&lt;/em&gt;=-0.152, &lt;em&gt;P&lt;/em&gt; = 0.000). There were significant differences in the distribution of disc position amongst condylar position (&lt;em&gt;P&lt;/em&gt; &lt; 0.05), but there was no linear correlation (&lt;em&gt;P&lt;/em&gt; = 0.159).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;The mutual distribution of disc morphology, disc position, condylar morphology and condylar position was statistically significant. Disc displacement did not necessarily lead to condylar bone changes, but 92.7 % TMJs with condylar bone abnormalities had disc displ","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101940"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additively manufactured custom-made subperiosteal implant rehabilitation for severely atrophic maxillary molar area: A technical note 用添加剂制造的定制骨膜下种植体修复严重萎缩的上颌磨牙区:技术说明。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101917
{"title":"Additively manufactured custom-made subperiosteal implant rehabilitation for severely atrophic maxillary molar area: A technical note","authors":"","doi":"10.1016/j.jormas.2024.101917","DOIUrl":"10.1016/j.jormas.2024.101917","url":null,"abstract":"<div><p>Implant-prosthetic rehabilitations of severely atrophic posterior maxillary sectors currently is challenging, often requiring multiple surgeries and long rehabilitation times. Recently, graftless techniques (e.g. zygomatic, pterygoid and nasal implants) have gained popularity as they offer a reduction in rehabilitation time, aligning more closely with patient preferences but may not be feasible for sectorial rehabilitations. Subperiosteal implants, suggested for full-arch rehabilitations of atrophic maxilla<span>, haven't been explored for sectorial rehabilitations. In this report we present the case of a patient with maxillary molar edentulism, rehabilitated with a subperiosteal implant.</span></p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101917"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Numerical study of the impact of osteotomies and distractor location in surgically assisted rapid palatal expansion for transverse maxillary deficiency 关于截骨和牵引器位置对上颌骨横向缺损手术辅助快速腭扩展的影响的数值研究。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101916
{"title":"Numerical study of the impact of osteotomies and distractor location in surgically assisted rapid palatal expansion for transverse maxillary deficiency","authors":"","doi":"10.1016/j.jormas.2024.101916","DOIUrl":"10.1016/j.jormas.2024.101916","url":null,"abstract":"<div><h3>Introduction</h3><p>This paper employs finite element analysis to assess the biomechanical behavior of surgically assisted rapid palatal expansion (SARPE) with a bone-borne transpalatal distractor (TPD) by varying surgical parameters.</p></div><div><h3>Material and methods</h3><p>Nine models were constructed to scrutinize the effects of pterygomaxillary disjunction (PMD), lateral osteotomy positioning, and TPD placement on displacement profiles and Von Mises stresses. These models encompassed variations such as no, unilateral or bilateral PMD, asymmetrical lateral osteotomy, and five TPD locations.</p></div><div><h3>Results</h3><p>Performing a PMD reduces posterior resistance to transverse expansion, resulting in 10–20 % stress reduction around the maxillofacial complex. No significant changes in horizontal tipping were observed post-PMD. The asymmetric lateral osteotomy model exhibited larger displacements on the side with a more superiorly positioned osteotomy. Reduced stresses were observed at the maxillary body and medial pterygoid plate (superiorly), while increased stresses were observed at the medial (inferiorly) and lateral pterygoid plates. More posterior TPD placement facilitated more parallel expansion thus less horizontal tipping, albeit with increased vertical tipping.</p></div><div><h3>Discussion</h3><p>SARPE procedures (distractor and osteotomy positions) can be tailored based on desired outcomes. PMD reduces stress within the maxillofacial complex but doesn't significantly affect tipping. Higher lateral osteotomies lead to increased displacements, more posterior distractors to more parallel expansion.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101916"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141052358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Categorizing temporomandibular joint arthroscopic procedures for a better clinical practice and teaching 对颞下颌关节关节镜手术进行分类,以改进临床实践和教学。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101808
{"title":"Categorizing temporomandibular joint arthroscopic procedures for a better clinical practice and teaching","authors":"","doi":"10.1016/j.jormas.2024.101808","DOIUrl":"10.1016/j.jormas.2024.101808","url":null,"abstract":"<div><h3>Objective</h3><p><span>To provide some clarity to the confusion in the terminology used to classify arthroscopic procedures for the treatment of </span>temporomandibular joint<span> (TMJ) internal derangement (ID) and osteoarthrosis (OA).</span></p></div><div><h3>Material and methods</h3><p>The author introduces a new method for categorizing TMJ arthroscopic procedures more accurately, intending to establish a reference point from which further clinical series may built their analyses.</p></div><div><h3>Results</h3><p>Six categories are proposed for establishing a clear distinction among performed arthroscopic procedures: Level Ia, arthroscopic lavage<span><span><span> (AL); Level Ib, arthroscopic lysis and lavage (ALL); Level Ic, ALL “needle-therapy”; Level IIa, simple operative arthroscopy (OA); Level IIb, advanced OA; and Level III, OA with discopexy. Several arthroscopic procedures, such as lysis of adherences, coblation of the retrodiscal tissue, anterior </span>myotomy of the lateral pterigoid muscle, or discopexy, are classified in each category depending on the need (or not) to use of one or two working </span>cannulas.</span></p></div><div><h3>Conclusion</h3><p>Teaching and training of maxillofacial surgeons in the acquisition of the skills to perform arthroscopy should be based on a step-by-step approach following this proposed classification. Besides, future clinical series on arthroscopy of the TMJ for the treatment of ID and/or osteoarthrosis may benefit from a clear distinction of the performed arthroscopic procedure in terms of evaluating outcomes and complications.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101808"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of nasal respiration and three-dimensional airway volume changes in orthognathic surgery patients 评估正颌外科手术患者的鼻腔呼吸和三维气道容积变化
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101987
Hayrunisa Koçyiğit Daştan , Mustafa Temiz , Sümer Münevveroğlu , Sina Uçkan
{"title":"Assessment of nasal respiration and three-dimensional airway volume changes in orthognathic surgery patients","authors":"Hayrunisa Koçyiğit Daştan ,&nbsp;Mustafa Temiz ,&nbsp;Sümer Münevveroğlu ,&nbsp;Sina Uçkan","doi":"10.1016/j.jormas.2024.101987","DOIUrl":"10.1016/j.jormas.2024.101987","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of this study was to evaluate the effect of maxillary movements in orthognathic surgery on nasal airway volume change and its correlation with airflow and resistance.</p></div><div><h3>Materials and methods</h3><p>This study included 25 patients (8 male, 17 female) with Class II (6 patients) or Class III (19 patients) malocclusion. All patients underwent Le Fort I and bilateral sagittal split ramus osteotomy. Nasal airflow and resistance were measured by using rhinomanometry and acoustic rhinometry pre and six months post-operatively. Nasal volume was measured using computed tomography before surgery and six months after surgery.</p></div><div><h3>Results</h3><p>Nasal volume increased in 10 out of 11 patients with CCW (counterclockwise) rotation and decreased in 1 patient while, nasal volume increased in 5 patients with CW (clockwise) rotation and decreased in 9 patients. Superior nasal airway volume increased significantly, while the effects on nasal flow and resistance were not significant. Additionally, no significant correlation was found between airway volume changes and variations in airflow and resistance.</p></div><div><h3>Conclusion</h3><p>CCW rotation in orthognathic surgery patients significantly increased superior nasal airway volume but did not improve nasal airway flow and resistance</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101987"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guselkumab: A new etiological factor of medication related osteonecrosis of the jaw (MRONJ)? A case report 古舍库单抗:药物相关性颌骨坏死(MRONJ)的新病因?病例报告。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101985
Monica Marotta , Paolo Boffano , Errico Prota , Martina Ferrillo , Silvia Leone , Vittorio Fusco , Mario Migliario
{"title":"Guselkumab: A new etiological factor of medication related osteonecrosis of the jaw (MRONJ)? A case report","authors":"Monica Marotta ,&nbsp;Paolo Boffano ,&nbsp;Errico Prota ,&nbsp;Martina Ferrillo ,&nbsp;Silvia Leone ,&nbsp;Vittorio Fusco ,&nbsp;Mario Migliario","doi":"10.1016/j.jormas.2024.101985","DOIUrl":"10.1016/j.jormas.2024.101985","url":null,"abstract":"<div><p>Medication Related Osteonecrosis of the Jaw (MRONJ) has traditionally been mostly attributed to the exposure to antiresorptive agents such as bisphosphonates and denosumab. Nevertheless, following the development of new medications in oncology, the spectrum of drugs associated with MRONJ widened, with, for example, tyrosine kinase inhibitors, mTOR inhibitor, or monoclonal antibodies against VEGF.</p><p>To date, MRONJ has not been assessed or reported in patients treated with guselkumab so far. Guselkumab is a fully human IgG1λ monoclonal antibody that selectively targets the p19 protein subunit of extracellular human IL-23 and inhibits its intracellular and downstream signalling. It consists of two identical light chains and two identical heavy chains. The four chains are linked together by covalent disulfide bonds and noncovalent protein-protein interactions.</p><p>The aim of this article is to report a case of a patient with severe psoriasic arhtritis and plaque psoriasis who presented with a clinical condition that could resemble a MRONJ following guselkumab therapy and a dental root extraction.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101985"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical variations of the lateral pterygoid plate and their implications for temporomandibular disorders: A CBCT study 翼侧板的解剖变异及其对颞下颌关节紊乱的影响:CBCT 研究。
IF 1.8 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101989
Hacer Eberliköse , Kübra Öztürk , Rıdvan Akyol , Burak Bilecenoğlu
{"title":"Anatomical variations of the lateral pterygoid plate and their implications for temporomandibular disorders: A CBCT study","authors":"Hacer Eberliköse ,&nbsp;Kübra Öztürk ,&nbsp;Rıdvan Akyol ,&nbsp;Burak Bilecenoğlu","doi":"10.1016/j.jormas.2024.101989","DOIUrl":"10.1016/j.jormas.2024.101989","url":null,"abstract":"<div><h3>Objective</h3><p>TMD is a multifaceted condition with various contributing factors, but the actual impact of the lateral pterygoid plate on the development of TMD remains uncertain. This research aims to investigate the relationship between anatomical variations of the lateral pterygoid plate (LPP), including its angle and proximity to the condyle, and the prevalence of temporomandibular disorders (TMD), to improve diagnostic accuracy and therapeutic approaches for TMD.</p></div><div><h3>Materials &amp; Methods</h3><p>A retrospective analysis was conducted on 189 Cone Beam Computed Tomography (CBCT) images of individuals aged 18 to 45. Inclusion criteria were based on definitive diagnoses of degenerative joint disease, excluding individuals with orthodontic treatments, injuries, or craniofacial disorders.Participants were divided into TMD and control groups using standardized DC/TMD protocols for assessment. A radiologist, blinded to the patient's clinical status, then analyzed the CBCT images. LPP dimensions, angles, and condyle distances were measured using OnDemand 3D Imaging Software.</p></div><div><h3>Results</h3><p>The study found a statistically significant higher average LPP length in females compared to males (right LPP <em>p</em> &lt; 0,001, left LPP <em>p</em> = 0,004<strong>),</strong> with no significant differences in LPP-condyle distances and angles between genders. Comparing the TMD and control groups revealed a positive correlation between lateral plate angles and TMJ disorders (<em>p</em> = 0,044), suggesting a potential biomechanical linkage.</p></div><div><h3>Conclusion</h3><p>Conclusively, the study challenges the assumption that LPP anatomical variations significantly impact TMD while underscoring a potential link between LPP angle and TMD. The novel insight into the potential role of the LPP angle in TMD provides a new direction for research and clinical practice, emphasizing the importance of considering subtle anatomical differences in the management of TMD.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101989"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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