Efficacy of Acellular dermal matrix simultaneous with implant placement: A systematic review and meta-analysis of clinical trials.

IF 2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-04-11 DOI:10.1016/j.jormas.2025.102371

Malik Alkabazi, Nawel Ouakouak, Ebtesam Aldieb

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引用次数: 0

Abstract

Purpose: The vertical soft tissue thickness over the implant is essential for long-term procedure success and for biological integration of the suprabony soft tissue component, consequently, development of alternatives to autogenous soft tissue grafts such as allogeneic and xenogeneic grafts were needed. Acellular dermal matrix (ADM) is utilized to provide structural support for angiogenesis, revascularization and tissue remodeling in soft tissue augmentation, recession, and increasing the keratinized tissue width. At this point, the aim of this systematic review was to evaluate the amount of soft tissue height (STH) gained after augmenting the ADM in combination with the dental implants.

Methods: A systematic search was performed in five databases. The primary outcome measure was STH change. Secondary outcomes included marginal bone loss (MBL) and pocket probing depth (PPD) at implant sites.

Results: Six studies, with 200 participants, and reported pre- and post-operative mean of vertical tissue thickness, MBL, and PPD around implants were included in the meta-analysis. The pooled mean difference (MD) of STH was 0.84 (95 % CI:0.28 to 1.39) with a p-value < 0.0001. A total of three studies, reported MBL. The pooled MD of MBL around implants, comparing the mean change from baseline to 12 months. The random effect model revealed a MD of 0.07mm (95 % CI: -0.21 to 0.35 mm, p= 0.6325). Calculation of pooled MD of PPD at implant sites, comparing ADM groups to the control groups in three studies; the random effect model revealed a MD of -0.13mm (95 % CI: -0.47 to 0.22 mm, p= 0.4742).

Conclusion: While Acellular dermal matrix significantly improves vertical soft tissue thickness, it does not significantly impact marginal bone loss or pocket probing depth.

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脱细胞真皮基质同时植入的疗效：临床试验的系统回顾和荟萃分析。

目的：种植体上的垂直软组织厚度对于长期手术成功和上颌骨软组织成分的生物整合至关重要，因此，需要开发自体软组织移植物的替代品，如异体和异种移植物。脱细胞真皮基质（ADM）在软组织增大、萎缩和增加角质组织宽度中为血管生成、血管重建和组织重塑提供结构支持。在这一点上，本系统综述的目的是评估在增加ADM与种植体结合后获得的软组织高度（STH）。方法：系统检索5个数据库。主要结局指标是STH变化。次要结果包括种植体部位的边缘骨丢失（MBL）和口袋探测深度（PPD）。结果：meta分析包括6项研究，200名参与者，并报告了植入物周围垂直组织厚度、MBL和PPD的术前和术后平均水平。STH的合并平均差（MD）为0.84 (95% CI:0.28 ~ 1.39)， p值< 0.0001。共有三项研究报道了MBL。种植体周围MBL的总MD，比较从基线到12个月的平均变化。随机效应模型显示MD为0.07mm （95% CI: -0.21 ~ 0.35 mm, p= 0.6325）。计算种植体部位PPD的总MD，比较三个研究中ADM组与对照组的差异；随机效应模型显示MD为-0.13mm （95% CI: -0.47 ~ 0.22 mm, p= 0.4742）。结论：脱细胞真皮基质可显著改善软组织垂直厚度，但对边缘骨丢失及穿刺深度无显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.