Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Objectifying aesthetic outcomes following face transplantation – the AI research metrics model (CAARISMA ® ARMM)","authors":"Leonard Knoedler ,&nbsp;Cosima C. Hoch ,&nbsp;Samuel Knoedler ,&nbsp;Felix J. Klimitz ,&nbsp;Thomas Schaschinger ,&nbsp;Tobias Niederegger ,&nbsp;Max Heiland ,&nbsp;Steffen Koerdt ,&nbsp;Rainer Pooth ,&nbsp;Martin Kauke-Navarro ,&nbsp;Alexandre G. Lellouch","doi":"10.1016/j.jormas.2025.102277","DOIUrl":"10.1016/j.jormas.2025.102277","url":null,"abstract":"<div><h3>Background</h3><div>Face transplantation (FT) offers a reconstructive option for patients with severe facial disfigurements by restoring both function and appearance. Aesthetic outcomes, which are crucial to psychological well-being and social reintegration, have historically been evaluated subjectively. This study introduces the AI Research Metrics Model (CAARISMA ® ARMM), a machine learning-based medical device designed to objectively assess aesthetic outcomes in FT patients.</div></div><div><h3>Methods</h3><div>Overall, 14 FT patients were analyzed using CAARISMA ® ARMM, which evaluates 3 key aesthetic indices: the Facial Youthfulness Index (FYI), Facial Aesthetic Index (FAI), and Skin Quality Index (SQI). Preoperative, postoperative, and pre-trauma images were processed to assess improvements in facial aesthetics. Statistical analysis was performed to compare changes in these indices across the different time points.</div></div><div><h3>Results</h3><div>Postoperative scores for FYI, FAI, and SQI were significantly higher than preoperative scores (<em>p</em> &lt; 0.0001), indicating substantial aesthetic improvements. No significant differences were found between postoperative and pre-trauma images, suggesting that FT can effectively restore a patient's pre-injury appearance. Aesthetic improvements were consistent across different age and gender groups, with no notable disparities in outcomes.</div></div><div><h3>Conclusion</h3><div>CAARISMA ® ARMM offers a reliable and objective framework for objectifying aesthetic outcomes following FT, allowing for more standardized assessments. This medical device can potentially improve patient-surgeon communication, enhance surgical planning, and serve as a benchmark for evaluating long-term aesthetic success in FT patients. Future research should focus on expanding CAARISMA ® ARMM's application to larger and more diverse patient populations.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102277"},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT, and systematic review ideas to oral and maxillofacial surgeons: Comment","authors":"Hinpetch Daungsupawong,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.jormas.2024.102000","DOIUrl":"10.1016/j.jormas.2024.102000","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102000"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of preoperative psychiatric intervention for postoperative delirium after major oral and maxillofacial surgery with free flap reconstruction","authors":"Yukie Nitta ,&nbsp;Takuro Sanuki ,&nbsp;Shigekazu Sugino ,&nbsp;Masahiro Sugimoto ,&nbsp;Kanta Kido","doi":"10.1016/j.jormas.2024.102026","DOIUrl":"10.1016/j.jormas.2024.102026","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative delirium (POD) is a severe complication associated with various adverse outcomes, especially in older patients. Although the incidence and risk factors for POD have been explored in general surgery, they have not been fully elucidated. Early identification of high-risk patients and active preoperative intervention are considered essential for the prevention of POD. Recently, psychiatric consultation intervention have been shown to prevent delirium. This study investigated the effect of preoperative psychiatric interventions on preventing POD in our specific surgical context.</div></div><div><h3>Materials and Methods</h3><div>This retrospective, single-center observational study included 86 patients who underwent major oral and maxillofacial surgery with free flap reconstruction between 2016 and 2023. The effect of psychiatric intervention were compared between patients with and without delirium.</div></div><div><h3>Results</h3><div>Preoperative psychiatric intervention did not reduce the incidence of POD. The incidence of POD was 29.1 %. Univariate analyses showed no significant associations between POD and any clinical variables.</div></div><div><h3>Conclusion</h3><div>There was no difference in the incidence of POD between patients who received preoperative psychiatric intervention and those who did not, and further investigation is needed to determine the efficacy of preoperative psychiatric intervention in the prevention of POD.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102026"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An 11-year multicentric surgical experience on pediatric orbital floor trapdoor fracture: A World Oral Maxillofacial Trauma (WORMAT) project","authors":"Paolo Cena ,&nbsp;Immacolata Raco ,&nbsp;Fabio Roccia ,&nbsp;Sobrero Federica ,&nbsp;Emil Dediol ,&nbsp;Boris Kos ,&nbsp;Gian Battista Bottini ,&nbsp;Maximilian Goetzinger ,&nbsp;Sahand Samieirad ,&nbsp;Luis Fernando de Oliveira Gorla ,&nbsp;Valfrido Antonio Pereira-Filho ,&nbsp;Petia Pechalova ,&nbsp;Angel Sapundzhiev ,&nbsp;Marko Lazíc ,&nbsp;Vitomir S. Konstantinovic ,&nbsp;Emanuele Zavattero ,&nbsp;Anamaria Sivrić ,&nbsp;Mario Kordić ,&nbsp;Sajjad Abdur Rahman ,&nbsp;Tabishur Rahman ,&nbsp;Kathia Dubron","doi":"10.1016/j.jormas.2024.102033","DOIUrl":"10.1016/j.jormas.2024.102033","url":null,"abstract":"<div><h3>Introduction</h3><div>Trapdoor fractures of the orbital floor occur almost exclusively in the paediatric population. Despite being widely discussed in the literature, their management remains controversial. The objective of this retrospective study was to analyse the surgical experiences on paediatric trapdoor fractures in the maxillofacial centres participating in the WORMAT project.</div></div><div><h3>Materials and methods</h3><div>14 centres collected data for patients aged ≤16 years operated between January 2011 and December 2022. The demographic, cause and type of fracture, timing from injury to surgery, surgical approach, type of floor repair and outcomes were recorded. Diplopia, surgical wound infection, hardware loosening and dysesthesia in the infraorbital nerve area were recorded at follow-up.</div></div><div><h3>Results</h3><div>43 patients were included: 25 children (0–12 y) and 18 adolescents (13–16 y) (mean age, 11.1 years). Surgical treatment was performed within 24 h in 51 % of the patients, within 24–72 h in 33 %, and beyond 72 h in the remaining. The orbital floor was repaired with a resorbable implant/membrane in 63 % of the patients, open reduction without an implant in 30 %, a titanium mesh implant in 3 adolescent patients. At follow-up (mean 16.3 months), 14 patients had residual diplopia in the upper fields, only two of these resolved within 6 months.</div></div><div><h3>Discussion</h3><div>A tendency toward an increased incidence of postoperative diplopia with longer intervals between trauma and surgery was observed. This study showed different choices regarding the material placed on the floor, with a preference for open reduction without implants in children, compared to the use of resorbable implants or membranes in adolescents.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102033"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of concentrated growth factor on wound healing, side effects, and postoperative complications following third molar surgery","authors":"Jingwen Lin ,&nbsp;Jiaming Liu ,&nbsp;Zhexuan Liu ,&nbsp;Wu Fu ,&nbsp;Hongfu Cai","doi":"10.1016/j.jormas.2024.102031","DOIUrl":"10.1016/j.jormas.2024.102031","url":null,"abstract":"<div><h3>Background</h3><div>Third molar surgery often results in postoperative complications such as pain, trismus, and facial swelling due to surgical trauma. Concentrated Growth Factor (CGF), a third-generation platelet concentrate, is believed to enhance wound healing due to its rich content of growth factors and fibrin.</div></div><div><h3>Methods</h3><div>This systematic review followed PRISMA guidelines and included a search of PubMed, Embase, and Cochrane Library up to April 18, 2024. Randomized controlled trials involving CGF-treated versus non-CGF-treated patients undergoing third molar surgery were included. Risk of bias was assessed using the Cochrane Collaboration RoB 2.0.</div></div><div><h3>Results</h3><div>Ten studies were included. CGF significantly improved wound healing, with enhanced soft and hard tissue recovery. Pain relief was notable on postoperative days 3 and 7, although results varied. CGF reduced facial swelling significantly on days 3 and 7 post-surgery. Trismus outcomes were mixed, with some studies reporting significant alleviation and others showing no advantage. CGF showed potential in reducing dry socket incidence, though evidence was not robust.</div></div><div><h3>Conclusions</h3><div>CGF appears to promote wound healing and reduce postoperative complications such as pain and swelling after third molar surgery. However, its effects on trismus and dry socket incidence remain controversial. Further research with standardized measures is needed to confirm these findings.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102031"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal giant craniofacial fibrous dysplasia in a very young child","authors":"Kevin Perge ,&nbsp;Sara Cabet ,&nbsp;Solene Bergignat ,&nbsp;Deborah Gensburger ,&nbsp;Roland Chapurlat ,&nbsp;Marc Nicolino","doi":"10.1016/j.jormas.2024.101996","DOIUrl":"10.1016/j.jormas.2024.101996","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 101996"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Ameloblastoma in Sub-Saharan Africa: A systematic review and meta-analysis","authors":"Adetayo Aborisade ,&nbsp;Chizoba Okolo ,&nbsp;Olugbenga Akinsanya ,&nbsp;Chika Oguchi ,&nbsp;Olusegun Alalade ,&nbsp;Adeniyi Oluwadaisi","doi":"10.1016/j.jormas.2024.102001","DOIUrl":"10.1016/j.jormas.2024.102001","url":null,"abstract":"<div><h3>Introduction</h3><div>Ameloblastoma is the most common odontogenic tumor (OT) accounting for about 1- 3 % of all tumors and tumor-like lesions of the head and neck region. Contrasting reports from documented studies have observed that the relative frequency of ameloblastomas is higher in the black population as compared to Caucasians. This is a systematic review and meta-analysis of Sub-Sahara African prevalence of Ameloblastoma.</div></div><div><h3>Methods</h3><div>The MEDLINE, SCOPUS, and AJOL databases were searched for relevant studies published from 1980 till date. Papers selected for full-text review were included in the systematic review if they provided a hospital or population-based prevalence of Ameloblastoma. Manual searching of selected articles’ reference list was also performed to include additional studies. Two individuals independently performed abstract and full-text reviews, data extraction, and quality assessment of the papers. Random-effects models and/or meta-regression were used to generate pooled estimates by country, sex, and year of data collection.</div></div><div><h3>Results</h3><div>Of 264 abstracts screened, 166 articles were selected for full-text review. A total of 22 studies met the inclusion criteria and all articles were hospital-based. The pooled prevalence for Ameloblastoma was 12 % (CI 95 %: 9 % - 15 %). Increasing participant age was not associated with a higher Ameloblastoma prevalence. Prevalence was higher in Nigeria (13 %, CI 95 %: 10 % - 17 %) than in other sub-Saharan countries (9 %, CI 95 %: 6 % - 14 %). Sex, country, and year of data collection were not associated with statistically significant different estimates of prevalence.</div></div><div><h3>Conclusion</h3><div>Significant gaps in data collection and overall knowledge about its epidemiology were identified, particularly about the population-based incidence of Ameloblastoma in sub-Saharan countries. Accurate estimates of the prevalence and incidence of Ameloblastoma are needed to plan for the health and social services that will be required to deal with this enigmatic lesion.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102001"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of augmented reality combine patient-specific implants (PSI) applied to navigation in mandibular genioplasty: A phantom experiment","authors":"Shi-Xi He ,&nbsp;Cheng Ma ,&nbsp;Zong-Yi Yuan,&nbsp;Tian-feng Xu,&nbsp;Jin-zhi Wei,&nbsp;Yin-yu Shang,&nbsp;Xuan-ping Huang","doi":"10.1016/j.jormas.2024.102039","DOIUrl":"10.1016/j.jormas.2024.102039","url":null,"abstract":"<div><div><strong>Purpose:</strong> Genitoplasty is becoming more and more common, and it is important to improve the accuracy of the procedure and simplify the procedure. This experiment explores the feasibility of using augmented reality (AR) technology combined with PSI titanium plates for navigational assistance in genioplasty performed on models, aiming to study the precision of such surgical interventions.</div><div><strong>Methods:</strong> Twelve genioplasty procedures were designed and implemented on 3D-printed resin mandibular models by the same surgeon using three different approaches: AR+3DT group (AR+PSI) , 3DT group (patient-specific titanium plate) , and a traditional free-hand group(FH group). Postoperative models were assessed using CBCT to evaluate surgical accuracy.</div><div><strong>Results:</strong> In terms of osteotomy accuracy, the AR group demonstrated a surgical error of 0.9440±0.5441 mm, significantly lower than the control group, which had an error of 1.685±0.8907 mm (<em>P</em> &lt; 0.0001). In experiments positioning the distal segment of the chin, the overall centroid shift in the AR group was 0.3661±0.1360 mm, significantly less than the 2.304±0.9629 mm in the 3DT group and 1.562±0.9799 mm in the FH group (<em>P</em> &lt; 0.0001). Regarding angular error, the AR+3DT group showed 2.825±1.373°, significantly &lt;8.283±3.640° in the 3DT group and 7.234±5.241° in the FH group.</div><div><strong>Conclusion</strong>: AR navigation technology combined with PSI titanium plates demonstrates higher surgical accuracy compared to traditional methods and shows feasibility for use. Further validation through clinical trials is necessary.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102039"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandibular reconstruction after post-traumatic complex fracture: Comparison analysis between traditional and virtually planned surgery","authors":"Stefania Troise ,&nbsp;Gianluca Renato De Fazio ,&nbsp;Umberto Committeri ,&nbsp;Raffaele Spinelli ,&nbsp;Maria Nocera ,&nbsp;Emanuele Carraturo ,&nbsp;Giovanni Salzano ,&nbsp;Antonio Arena ,&nbsp;Vincenzo Abbate ,&nbsp;Paola Bonavolontà ,&nbsp;Antonio Romano ,&nbsp;Giovanni Dell'Aversana Orabona ,&nbsp;Luigi Angelo Vaira ,&nbsp;Pasquale Piombino","doi":"10.1016/j.jormas.2024.102029","DOIUrl":"10.1016/j.jormas.2024.102029","url":null,"abstract":"<div><h3>Background</h3><div>Jaw reconstruction after complex post-traumatic fracture is still a challenge for surgeons using traditional surgery. Virtual surgical planning has proven to be a valid tool for managing these fractures. The aim of this study is to quantitatively evaluate the VSP effectiveness compared to traditional surgery in the management of complex mandibular fractures.</div></div><div><h3>Methods</h3><div>30 patients with diagnosis of complex mandibular fracture were enrolled and divided in two groups: Group A (virtually planned surgery), The plate was pre-modeled and employed during the surgery; Group B (traditional surgery), the plate was shaped directly during the surgery. Virtually planned and post-operative Computer Tomography were after compared for both the groups to highlight discrepancies in mm.</div></div><div><h3>Results</h3><div>Fracture surgical reduction was successful without intraoperative complications. In Group A, all the mean discrepancies’ values were &lt;1 mm while in Group B the values were included between 1.36 and 1.94 mm. The mean operative time was 69 min for Group A, while 106 min for Group B.</div></div><div><h3>Conclusions</h3><div>Fracture virtual reduction and realization of pre-modeled plate are able to guarantee a more anatomically correct reduction and a decrease in operating times. These outcomes translate into a decrease in both short and long-term complications.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102029"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel m6A reader RBFOX2 expression is increased in oral squamous cell carcinoma and promotes tumorigenesis","authors":"Paramasivam Arumugam ,&nbsp;Senthil Murugan M ,&nbsp;Vijayashree Priyadharsini Jayaseelan","doi":"10.1016/j.jormas.2024.102041","DOIUrl":"10.1016/j.jormas.2024.102041","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Oral squamous cell carcinoma (OSCC) is a significant global health concern due to its aggressive nature and poor prognosis. Recent research has highlighted the important role of RNA modifications in cancer biology, especially N6-methyladenosine (m6A) modifications, which are controlled by a complex interplay of m6A regulators. This study specifically investigates RBFOX2, a new m6A reader, and its involvement in OSCC.</div></div><div><h3>Methods</h3><div>Our study primarily utilized OSCC tissue, adjacent normal tissue samples, OSCC cell lines, and normal healthy oral keratinocytes to validate <em>RBFOX2</em> mRNA expression. Additionally, we used the TCGA-HNSCC dataset for large cohort analysis and clinicopathological characterization. Furthermore, we visualized the RBFOX2 network to identify the primary functions of the protein.</div></div><div><h3>Results</h3><div>Our research shows a noticeable increase in RBFOX2 expression in OSCC tissues compared to adjacent non-tumorous tissues, as determined by quantitative PCR and immunohistochemistry analyses. Functional pathway enrichment analysis revealed that RBFOX2 is involved in the receptor tyrosine kinase signaling pathway and the Hippo signaling pathway, which plays a critical role in oral cancer development and progression. Clinically, elevated RBFOX2 expression correlated with advanced tumor stages and poorer patient outcomes, demonstrating its prognostic value. These findings indicate that RBFOX2 acts as an oncogenic driver in OSCC as an m6A reader, facilitating the expression of m6A-modified oncogenes.</div></div><div><h3>Conclusion</h3><div>Our study identifies RBFOX2 as a critical player in OSCC pathogenesis and opens avenues for novel therapeutic strategies targeting the m6A regulatory machinery in this malignancy.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102041"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}