Journal of Stomatology Oral and Maxillofacial Surgery最新文献

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The hidden cost of the perfect case report: Are we publishing only successes? 完美案例报告的隐性成本:我们只发表成功案例吗?
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jormas.2026.102713
Anuj Jain
{"title":"The hidden cost of the perfect case report: Are we publishing only successes?","authors":"Anuj Jain","doi":"10.1016/j.jormas.2026.102713","DOIUrl":"10.1016/j.jormas.2026.102713","url":null,"abstract":"<div><h3>Background</h3><div>Case reports play a critical role in Oral and Maxillofacial Surgery (OMFS) by documenting rare presentations, unexpected complications, and complex intraoperative events. However, contemporary publication patterns suggest a bias toward reporting “ideal” outcomes, potentially limiting opportunities for complication-based learning.</div></div><div><h3>Methods</h3><div>A narrative review of bibliometric studies and large-scale clinical reports published between 2008 and 2025 was conducted using journal archives and database searches (PubMed, Scopus). The review synthesised trends in case report publication across major OMFS journals and compared these with real-world complication rates reported in high-volume clinical studies.</div></div><div><h3>Results</h3><div>Case report publications in OMFS journals have progressively declined over the past decade. In BJOMS, complication- or novelty-focused short communications decreased from 52 % in 2008–2009 to 35 % in 2010–2011. In contrast, large clinical cohorts document substantial adverse event rates, ranging from 3.6 % in third molar surgery to 43.7 % in orthognathic surgery. This discrepancy highlights a growing gap between clinical reality and published literature.</div></div><div><h3>Conclusion</h3><div>The underrepresentation of complication-focused case reports skews perceptions of OMFS practice and limits experiential learning. Transparent, structured reporting of complications can enhance patient safety, strengthen surgical education, and better align published evidence with real-world outcomes. Journals should adopt policies that encourage and normalize the publication of clinically meaningful adverse events.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102713"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and biomechanical evaluation of subject-specific, anatomically complete 3D finite element models of the temporomandibular joint using the four-finger mouth-opening test 基于四指开口试验的颞下颌关节三维有限元模型的开发和生物力学评价
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2026-01-01 DOI: 10.1016/j.jormas.2025.102706
Ananta Jain , Rashmi Uddanwadikar , Sunita Shrivastav
{"title":"Development and biomechanical evaluation of subject-specific, anatomically complete 3D finite element models of the temporomandibular joint using the four-finger mouth-opening test","authors":"Ananta Jain ,&nbsp;Rashmi Uddanwadikar ,&nbsp;Sunita Shrivastav","doi":"10.1016/j.jormas.2025.102706","DOIUrl":"10.1016/j.jormas.2025.102706","url":null,"abstract":"<div><h3>Background</h3><div>Accurate biomechanical characterization of asymptomatic TMJ function requires anatomically complete, subject-specific models, yet such validated finite element (FE) frameworks remain limited.</div></div><div><h3>Objective</h3><div>To introduce and technically evaluate a novel MRI-validated, kinematically -driven, anatomically complete, subject-specific 3D nonlinear FE TMJ framework, and to demonstrate its biomechanical responses in one asymptomatic subject and two Class II cases with mild and moderate anterior disc displacement during the four-finger mouth-opening test.</div></div><div><h3>Methods</h3><div>Three subject-specific TMJ models were constructed using CBCT for hard tissues and high-resolution MRI for soft tissues. A hybrid anatomical workflow integrating 3D Slicer, Blender, and ANSYS SpaceClaim enabled complete maxillofacial reconstruction. Nonlinear FE simulations (ANSYS Workbench) quantified stresses in the disc, condylar head, condylar neck, articular eminence, and glenoid fossa using validated material properties, frictional contacts, and physiological kinematic loading derived from motion-capture trajectories.</div></div><div><h3>Results</h3><div>MRI-based geometric and kinematic validation showed &lt;5% error in disc rotational angle and condylar translation. In the asymptomatic subject, compressive stresses occurred in intermediate disc regions, with tensile stresses near anterior and posterior attachments. The mild displacement case showed elevated posterior disc and anterior condylar stresses, while the moderate case exhibited the highest disc, condylar head, and neck stresses 0.637 MPa and 1.40 MPa, respectively. Across all three individuals, maximum stresses occurred as the condyle advanced over the articular eminence.</div></div><div><h3>Conclusion</h3><div>This feasibility study introduces a validated, anatomically complete subject-specific FE TMJ model that captures rotation–translation in the asymptomatic case and restricted translation with elevated stresses in mild and moderate displacement, supporting future expansion.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102706"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral and maxillofacial schwannoma (OMSCH): An institutional study of 102 patients 口腔颌面神经鞘瘤(OMSCH): 102例患者的机构研究。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2025-12-05 DOI: 10.1016/j.jormas.2025.102678
Lingli Huang , Wenya Zhu , Qicheng Ye , Shengwen Liu , Hao Lu , Wenjun Yang , Wanlin Xu
{"title":"Oral and maxillofacial schwannoma (OMSCH): An institutional study of 102 patients","authors":"Lingli Huang ,&nbsp;Wenya Zhu ,&nbsp;Qicheng Ye ,&nbsp;Shengwen Liu ,&nbsp;Hao Lu ,&nbsp;Wenjun Yang ,&nbsp;Wanlin Xu","doi":"10.1016/j.jormas.2025.102678","DOIUrl":"10.1016/j.jormas.2025.102678","url":null,"abstract":"<div><h3>Background</h3><div>Oral and maxillofacial schwannoma (OMSCH) is a benign tumor originating from the Schwann cells of peripheral nerves in the oral and maxillofacial region, whose diagnosis and treatment remain challenging.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed OMSCH cases treated at our institution from January 2020 to June 2022. Demographics, clinical features, diagnostic methods, surgical approaches, and postoperative pathology were comprehensively evaluated.</div></div><div><h3>Results</h3><div>A total of 102 patients with OMSCH were included, ranging from 8 to 86 years, with a notable female predominance. The parotid gland was the most frequent site of involvement, while tongue was the most commonly affected structure within the oral cavity. Seventy-one patients (69.6 %) had tumors exceeding 2 cm in size. Magnetic resonance imaging (MRI) exhibited the highest diagnostic accuracy (20/46, 43.5 %). Eighty-five patients (83.3 %) underwent complete surgical resection, with intracapsular enucleation primarily employed for facial nerve schwannomas. Postoperative histopathology revealed a characteristic biphasic pattern and prominent S100/SOX10 immunohistochemical staining. Postoperative complications included tongue deviation in one patient and facial paralysis in 17 patients (16.7 %). No recurrences were observed during follow-up (30–69 months).</div></div><div><h3>Conclusion</h3><div>OMSCH is a rare tumor with limited diagnostic accuracy. MRI remains the preferred diagnostic modality, and surgical intervention generally results in favorable outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102678"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Speech outcomes following Le Fort I maxillary advancement in cleft lip and palate patients: A retrospective evaluation using the Borel-Maisonny classification 唇腭裂患者上颌推进后的言语效果:Borel-Maisonny分类的回顾性评价。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2025-12-24 DOI: 10.1016/j.jormas.2025.102693
Benedikta Kamdem , Oumama El Ezzi , Sophie Fries , Laurent Medinger , Anthony S. de Buys Roessingh
{"title":"Speech outcomes following Le Fort I maxillary advancement in cleft lip and palate patients: A retrospective evaluation using the Borel-Maisonny classification","authors":"Benedikta Kamdem ,&nbsp;Oumama El Ezzi ,&nbsp;Sophie Fries ,&nbsp;Laurent Medinger ,&nbsp;Anthony S. de Buys Roessingh","doi":"10.1016/j.jormas.2025.102693","DOIUrl":"10.1016/j.jormas.2025.102693","url":null,"abstract":"<div><h3>Objective</h3><div>To analyse the effect of maxillary advancement on speech in patients born with unilateral or bilateral cleft lip and palate (uCLP/bCLP).</div></div><div><h3>Methods</h3><div>Using the retrospective cohort study design, the investigators included children with uCLP or bCLP who underwent Le Fort I osteotomy for maxillary advancement between January 2013 and December 2023 at a Swiss university hospital. Predictor variables were cleft type (uCLP/bCLP) and amount of maxillary advancement measured on lateral cephalograms. The primary outcome was speech competency evaluated by two speech therapists using the Borel-Maisonny classification (A: velopharyngeal competence/excellent speech; B: borderline competence/good speech; C: incompetence/poor speech). Appropriate statistical analyses were performed, and <em>P</em> &lt; 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Forty-three non-syndromic CLP patients (mean age 16.4 ± 1.5 years; 37 % female) were included. The mean maxillary advancement was 6.6 ± 2.3 mm. Of the 36 patients classified as A or B preoperatively, 34 showed no change, while two (5.6 %) deteriorated from A to B. All seven patients with preoperative category C remained unchanged. Neither cleft type nor the extent of maxillary advancement significantly influenced postoperative speech (<em>p</em> = 0.65 and <em>p</em> = 0.80, respectively).</div></div><div><h3>Conclusion</h3><div>Although limited by sample size, this study suggests that speech deterioration after maxillary advancement in CLP patients with preoperative category A or B is uncommon. Conversely, Le Fort I osteotomy does not appear to improve speech in patients with preoperative category C.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102693"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and risk factors of cleft lip and/or palate in Ethiopia: A systematic review and meta-analysis 埃塞俄比亚唇裂和/或腭裂的患病率和危险因素:系统回顾和荟萃分析。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jormas.2026.102712
Mandefrogn Mammo Lemma , Firehiwot Gezahegn Abebe , Estifanos Esubalew Lewogineh
{"title":"Prevalence and risk factors of cleft lip and/or palate in Ethiopia: A systematic review and meta-analysis","authors":"Mandefrogn Mammo Lemma ,&nbsp;Firehiwot Gezahegn Abebe ,&nbsp;Estifanos Esubalew Lewogineh","doi":"10.1016/j.jormas.2026.102712","DOIUrl":"10.1016/j.jormas.2026.102712","url":null,"abstract":"<div><h3>Background</h3><div>Cleft lip and/or palate (CL/P) is the most common congenital orofacial anomalies worldwide, with a multifactorial etiology involving both genetic and environmental factors. This study aimed to estimate the pooled prevalence of CL/P in Ethiopia and identify the associated risk factors.</div></div><div><h3>Materials and Methods</h3><div>We systematically searched PubMed, Scopus, and Google Scholar for studies published between 1990 and 2023. We included observational studies (cross-sectional, cohort, case–control, descriptive, and prospective) that reported prevalence data for CL/P in Ethiopia. Data were extracted using a standardized Excel form, and statistical analyses were conducted using STATA version 18. The primary outcome was the pooled prevalence of CL/P. Heterogeneity was assessed using Cochrane’s Q test and the I² statistic, and meta-analysis was performed using a random-effects model. The methodological quality of the studies was assessed using the STROBE checklist (version 2007).</div></div><div><h3>Results</h3><div>Across ten studies comprising 19,024,539 births, the pooled birth prevalence of CL/P in Ethiopia was 0.24 per 1000 live births (95 % CI: 0.12–0.36). Considerable heterogeneity was observed among studies (I² = 99.94 %, τ² = 0.04, <em>Q</em> = 8546.85, <em>p</em> &lt; 0.001), reflecting substantial variability in prevalence estimates.</div></div><div><h3>Conclusion</h3><div>Although the prevalence of CL/P in Ethiopia is lower than the global average, it represents a significant public health concern. This underscores the need for strengthen preventive measures, promoting early detection, and expanding access to timely and comprehensive treatment services are essential for reducing the burden of these congenital anomalies.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102712"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomechanical evaluation of fixation systems in different segmental Le Fort I osteotomies: Patient-specific implants versus miniplates 不同节段Le Fort I截骨术中固定系统的生物力学评价:患者特异性植入物与微型钢板。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2025-11-22 DOI: 10.1016/j.jormas.2025.102666
Barış Erkut Türk, Mehmet Barış Şimşek
{"title":"Biomechanical evaluation of fixation systems in different segmental Le Fort I osteotomies: Patient-specific implants versus miniplates","authors":"Barış Erkut Türk,&nbsp;Mehmet Barış Şimşek","doi":"10.1016/j.jormas.2025.102666","DOIUrl":"10.1016/j.jormas.2025.102666","url":null,"abstract":"<div><h3>Background</h3><div>Patient-specific implants (PSIs) are increasingly used in orthognathic surgery; however, their biomechanical performance in multi-segment Le Fort I osteotomies has not been fully clarified.</div></div><div><h3>Objective</h3><div>To compare stress distribution and mechanical stability of PSIs and conventional miniplates in two- and three-piece segmental Le Fort I osteotomies using finite element analysis.</div></div><div><h3>Materials and methods</h3><div>Four three-dimensional maxillary models were constructed with 5 mm advancement and 5 mm expansion. Each model was fixed with either PSIs or miniplates. Oblique (30°) and vertical (125 N) forces were applied to the premolar–molar region. Maximum and minimum principal stresses in bone and von Mises stresses in fixation plates were analyzed.</div></div><div><h3>Results</h3><div>Three-piece osteotomies with miniplates exhibited the highest stress concentrations in both bone and plates. PSI fixation consistently reduced stress magnitudes and promoted more uniform load transfer under both oblique and vertical loading.</div></div><div><h3>Significance</h3><div>Compared with conventional miniplates, PSIs may provide enhanced biomechanical stability in segmental Le Fort I osteotomies; however, further clinical validation is required.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102666"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of static-guided pterygoid implant placement using mucosa-tooth-supported resin templates: a retrospective cohort study 使用粘膜牙支撑钛模板静态引导翼状体植入的准确性:一项回顾性队列研究。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2026-01-12 DOI: 10.1016/j.jormas.2026.102715
Giovanni Battista Menchini-Fabris , Paolo Toti , Young Min Park , Andrea Bernardis , Saverio Cosola , Tommaso Grandi
{"title":"Accuracy of static-guided pterygoid implant placement using mucosa-tooth-supported resin templates: a retrospective cohort study","authors":"Giovanni Battista Menchini-Fabris ,&nbsp;Paolo Toti ,&nbsp;Young Min Park ,&nbsp;Andrea Bernardis ,&nbsp;Saverio Cosola ,&nbsp;Tommaso Grandi","doi":"10.1016/j.jormas.2026.102715","DOIUrl":"10.1016/j.jormas.2026.102715","url":null,"abstract":"<div><h3>Purposes</h3><div>The aim of this retrospective cohort study was to evaluate the accuracy of pterygoid implant placement using static guides based on mucosa-tooth-supported resin templates in fully edentulous patients. In addition, the study assessed whether deviations at the neck and apex tended to compensate or amplify along the implant axis by introducing the differential parameters.</div></div><div><h3>Methods</h3><div>Thirty-four patients (mean age 63.7 ± 9.0 years) received 62 pterygoid implants between September 2022 and July 2023. Virtual implant planning was performed on cone-beam computed tomography (CBCT)-derived datasets, and 3D printed resin surgical guides were fabricated to transfer the plan to the surgical field. Postoperative CBCT scans were superimposed onto the virtual plan using voxel-based registration, allowing vertical and horizontal measurement of deviations at the implant neck (<em>v</em><sup>3</sup>, <em>h</em><sub>3</sub>) and apex (<em>v</em><sub>4</sub>, <em>h</em><sub>4</sub>), as well as angular discrepancies (<em>θ</em>). Compensation and amplification effects were analyzed by computing vertical and horizontal differentials Δ<em>v</em> and Δ<em>h</em>. Data were expressed as medians and interquartile ranges (iqr).</div></div><div><h3>Results</h3><div>At the neck level, median vertical deviation was –0.54(0.59) mm and horizontal deviation 0.78(0.60) mm. At the apex, median vertical deviation was –0.41(0.61) mm, while horizontal deviation increased to 1.06(0.48) mm. The difference between <em>h</em><sub>3</sub> and <em>h</em><sub>4</sub> was significant (<em>p</em> &lt; 0.0001), reflecting systematic amplification of horizontal misalignment. Angular deviation was low, with a median of 1.37(1.18) degrees. Analysis of Δ<em>v</em>, about 0(0.31) mm, and Δ<em>h</em>, +0.30(0.52) mm revealed that vertical errors were variably compensated apically, whereas horizontal errors tended to amplify. Quadrant analysis showed that while most implants displayed amplification, a subset exhibited partial or even double compensation when both vertical and horizontal deviations decreased apically.</div></div><div><h3>Conclusion</h3><div>Pterygoid implant placement with static guides based on mucosa-tooth-supported resin templates demonstrated high accuracy, with deviations lower than those reported in meta-analyses and angular discrepancies markedly reduced. The introduction of Δ<em>v</em> and Δ<em>h</em> provided a novel insight into error propagation, highlighting compensatory versus amplifying trajectories.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102715"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CEACAM1 regulates autophagy in oral squamous cell carcinoma through the PPAR signaling pathway CEACAM1通过PPAR信号通路调控口腔鳞状细胞癌的自噬。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2025-12-05 DOI: 10.1016/j.jormas.2025.102676
Sai Ma, Zhonghua Wang, Chao Li, Zhenli Liu, Xuan Zhang
{"title":"CEACAM1 regulates autophagy in oral squamous cell carcinoma through the PPAR signaling pathway","authors":"Sai Ma,&nbsp;Zhonghua Wang,&nbsp;Chao Li,&nbsp;Zhenli Liu,&nbsp;Xuan Zhang","doi":"10.1016/j.jormas.2025.102676","DOIUrl":"10.1016/j.jormas.2025.102676","url":null,"abstract":"<div><h3>Background</h3><div>Oral squamous cell carcinoma (OSCC), as one of the most common malignant tumors in the head and neck region, has a complex and diverse pathogenesis. An increasing number of studies indicate that cellular autophagy plays a significant role in the occurrence, development, and treatment of tumors. However, the specific mechanisms of autophagy in oral squamous cell carcinoma are not yet fully understood.</div></div><div><h3>Methods</h3><div>This study is based on the oral squamous cell carcinoma dataset GSE222673, and has conducted a gene set enrichment analysis (GSEA) on the whole genome, aiming to find potential enriched pathways among non-differentially expressed genes. Weighted gene co-expression network analysis (WGCNA) was used to identify key modules and determine the key hub genes within the modules. The experimental part employed Western Blot to verify the expression changes and functional roles of core molecules in OSCC cells.</div></div><div><h3>Results</h3><div>GSEA indicates that non-differentially expressed genes are enriched in mitochondrial autophagy, PPAR, Toll-like receptor, and MTOR signaling pathways. WGCNA identified 3794 hub genes, including the CEACAM1 gene. Further Western Blot experiments indicate that in OSCC cells, the CEACAM1 gene has a negative regulatory effect on the PPAR signaling pathway, and changes in its expression levels affect the upregulation or downregulation of key molecules PPAR, ILK, and PDK1. Furthermore, the overexpression of the CEACAM1 gene can promote the expression of autophagy-related molecules such as PINK1, Parkin, LC3I, LC3II, and mitochondrial fusion-related proteins OPA1, MFN2, as well as mitochondrial biogenesis-related proteins NRF1, TFAM in OSCC cells. The overexpression of the CEACAM1 gene inhibits the expression of mitochondrial fission-related proteins and promotes the expression of apoptosis-related proteins.</div></div><div><h3>Conclusions</h3><div>CEACAM1 regulates the PPAR signaling pathway key molecules, affecting OSCC cell autophagy, mitochondrial balance, and apoptosis.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102676"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging role of ultrasound in facial aesthetic procedures 超声在面部美容过程中的新兴作用。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2026-01-13 DOI: 10.1016/j.jormas.2026.102714
Davide Gerardi , Pierangelo Burdo , Gianluca Botticelli , Diana Torge , Francesca Angiolani , Fabiola Rinaldi , Giuseppe Varvara
{"title":"The emerging role of ultrasound in facial aesthetic procedures","authors":"Davide Gerardi ,&nbsp;Pierangelo Burdo ,&nbsp;Gianluca Botticelli ,&nbsp;Diana Torge ,&nbsp;Francesca Angiolani ,&nbsp;Fabiola Rinaldi ,&nbsp;Giuseppe Varvara","doi":"10.1016/j.jormas.2026.102714","DOIUrl":"10.1016/j.jormas.2026.102714","url":null,"abstract":"<div><h3>Objective</h3><div>Ultrasound imaging is gaining increasing relevance in facial aesthetic medicine due to its real-time, non-invasive, and radiation-free nature. The purpose of this scoping review was to explore the clinical applications of ultrasonography in aesthetic medicine.</div></div><div><h3>Materials and methods</h3><div>A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science to identify clinical studies evaluating the use of ultrasonography in facial aesthetic medicine. The search strategy included the following terms: \"aesthetic\", \"facial\", \"ultrasound\". PRISMA Extension for Scoping Review guidelines were used.</div></div><div><h3>Results</h3><div>A total of 6 studies were included in this review. Ultrasonography has been used to guide injections in facial aesthetic procedures such as filler and botulinum injection and to assess the thickness of the masseter muscle to evaluate the efficacy of masseter muscle hypertrophy treatment.</div></div><div><h3>Conclusions</h3><div>Ultrasonography enhances the safety of facial aesthetic procedures by guiding injections into the correct tissue layers and minimizing vascular risks. Priority should be given to the development of standardized protocols and an increase in randomized clinical trials.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102714"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-assisted translation in oral and maxillofacial surgery: A comparative evaluation 人工智能辅助翻译在口腔颌面外科:比较评价。
IF 2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2026-06-01 Epub Date: 2026-01-13 DOI: 10.1016/j.jormas.2026.102717
Murillo Martins Pinto , Erick Elienai Reis Araújo , Zacharie Rahhal , Dani Stanbouly , Ricardo Grillo
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