Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Evaluation of the aesthetic and functional effectiveness of primary closed rhinoseptoplasty: A study of 189 cases.","authors":"Jebrane Bouaoud ,&nbsp;Olivier Mathieu ,&nbsp;Clémence Mure ,&nbsp;Jean-Baptiste Belloc","doi":"10.1016/j.jormas.2025.102301","DOIUrl":"10.1016/j.jormas.2025.102301","url":null,"abstract":"<div><h3>Background</h3><div>With the increasing demand for rhinoplasty procedures, evaluating outcomes becomes crucial for improving surgical procedures. Nevertheless, there is a limited number of extensive studies exclusively dedicated to closed rhinoseptoplasty (RSP), emphasizing the evaluation of both aesthetic and functional dimensions. This study aims to assess the aesthetic and functional effectiveness of exclusively closed primary RSP procedures and to identify subgroups at risk of less favorable outcomes, providing valuable insights for preoperative planning. The study incorporates the widely used Nasal Obstruction Symptoms Evaluation (NOSE) and Rhinoplasty Outcome Evaluation (ROE) scores, making it the most comprehensive research to date in terms of sample size and subgroup analysis for closed approaches.</div></div><div><h3>Methods</h3><div>A total of 189 closed RSPs performed between January 2019 and June 2023 were prospectively evaluated. Follow-ups at 2, 6, and 12 months enabled a comprehensive understanding of the postoperative evolution. Statistical analyses included non-parametric the non-parametric Wilcoxon signed-rank test, Mann Whitney test, Kruskal-Wallis test, and Spearman coefficient, with a significance level of <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>The study reveals significant improvements in both aesthetic (ROE) and functional (NOSE) scores postoperatively, emphasizing the positive impact of closed RSP. Subgroup analyses unveiled factors influencing functional and aesthetic outcomes, contributing to a refined understanding of closed RSP.</div></div><div><h3>Conclusions</h3><div>This study not only reaffirms the effectiveness of closed RSP but also offers valuable insights into various factors influencing outcomes. The findings underscore the importance of considering both aesthetic and functional aspects in rhinoplasty planning, contributing to the evolving landscape of surgical practices.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102301"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Objectifying aesthetic outcomes following face transplantation - the AI research metrics model.\"","authors":"Elise Lupon","doi":"10.1016/j.jormas.2025.102300","DOIUrl":"10.1016/j.jormas.2025.102300","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102300"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircPVT1 promotes periodontitis progression by regulating miR-24-3p/HIF1AN pathway","authors":"Yuting Bian ,&nbsp;Jingwen Yu ,&nbsp;Yang Liu ,&nbsp;Yahong Shi ,&nbsp;Yujiao Hou ,&nbsp;Xin Liu","doi":"10.1016/j.jormas.2024.102198","DOIUrl":"10.1016/j.jormas.2024.102198","url":null,"abstract":"<div><h3>Purpose and background</h3><div>Periodontitis is a chronic inflammatory oral disease affecting half of the adult population. Circular RNA plays a critical role in periodontitis. CircPVT1(hsa_circ_0085536) was abundant in periodontitis tissues and cells but its mechanism are still unclear. We aim to explore the role of circPVT1 in periodontitis and elucidate how circPVT1 acts.</div></div><div><h3>Methods</h3><div>Gingival tissues from patients with periodontitis(n=20) and health participants(n=20) were collected and the expression of circPVT1 was measured by realtime quantitative PCR(RT-qPCR). Cell model for periodontitis was performed by PDLCs treated lipopolysaccharide(LPS). Cell Counting Kit-8(CCK-8), flow cytometry, enzyme-linked immunoabsorbent assay (ELISA), ALP staining and Alizarin red staining were conducted to detect cell viability, apoptosis, inflammatory and oxidative stress factors and osteogenic differentiation. The targeting microRNA(miRNA)/mRNA axis of circPVT1 was predicted and screened.</div></div><div><h3>Results</h3><div>circPVT1 was upregulated in the gingival tissues of patients with periodontitis. Silencing of circPVT1 inhibited cell viability, decreased inflammatory factors(IL-1β, TNF-α, IL-6) and oxidative stress factors, activated NRF-2 and HO-1 expression and promoted apoptosis and osteoclast differentiation in PDLCs after treated LPS. However, these effects were reversed by transfected miR-24–3p inhibitor and overexpressed of hypoxia-inducible factor 1 subunit alpha inhibitor(HIF1AN) in PDLCs.</div></div><div><h3>Conclusion</h3><div>circPVT1 promotes the progression of periodontitis by modulating NRF-2/HO-1 pathway via the miR-24–3p/HIF1AN axis.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102198"},"PeriodicalIF":1.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoral anastomosis technique as part of the reconstruction strategy following resection of intermediate and low-grade head and neck cancer","authors":"Thomas Bondi ,&nbsp;Nicolas Walhin ,&nbsp;Guillaume Henry ,&nbsp;Nadia Benmoussa-Rebibo ,&nbsp;Nicolas Leymarie ,&nbsp;Jean-François Honart","doi":"10.1016/j.jormas.2025.102282","DOIUrl":"10.1016/j.jormas.2025.102282","url":null,"abstract":"<div><h3>Introduction</h3><div>The gold standard for curative treatment of facial, oral, nasal, paranasal and pharyngeal cancers is excision and reconstruction surgery. Patients are increasingly demanding carcinologically effective and minimally invasive surgery with near ad integrum functional and aesthetic reconstruction. In malignant tumors with no indication for lymph node dissection, when the defect size dictates free flap reconstruction, the intrabuccal anastomosis technique comes closest to meeting these requirements.</div></div><div><h3>Material and methods</h3><div>In this single-center retrospective observational study, we reported a series of 5 patients with intermediate or low-grade head and neck cancer treated by surgery between 2022 and 2023 at the Cervico-facial Surgery Department of the Gustave Roussy Cancer Center. We collected clinical, therapeutic, histologic, and carcinologic data.</div></div><div><h3>Results</h3><div>All patients underwent tumor resection with fascio-cutaneous free flap reconstruction and dental rehabilitation in accordance with best practice recommendations. None of the patients had an indication for lymph node dissection. The histologic subtypes were glandular, epithelial, and cartilaginous-related. All anastomoses were performed on the facial vessels using an intraoral anastomosis technique.</div></div><div><h3>Conclusion</h3><div>Free flap with intraoral anastomosis technique may be the first intention reconstruction strategy for large defects following resection of intermediate and low-grade malignant tumors of the face and oral, oropharyngeal, nasal or paranasal cavities.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102282"},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objectifying aesthetic outcomes following face transplantation – the AI research metrics model (CAARISMA ® ARMM)","authors":"Leonard Knoedler ,&nbsp;Cosima C. Hoch ,&nbsp;Samuel Knoedler ,&nbsp;Felix J. Klimitz ,&nbsp;Thomas Schaschinger ,&nbsp;Tobias Niederegger ,&nbsp;Max Heiland ,&nbsp;Steffen Koerdt ,&nbsp;Rainer Pooth ,&nbsp;Martin Kauke-Navarro ,&nbsp;Alexandre G. Lellouch","doi":"10.1016/j.jormas.2025.102277","DOIUrl":"10.1016/j.jormas.2025.102277","url":null,"abstract":"<div><h3>Background</h3><div>Face transplantation (FT) offers a reconstructive option for patients with severe facial disfigurements by restoring both function and appearance. Aesthetic outcomes, which are crucial to psychological well-being and social reintegration, have historically been evaluated subjectively. This study introduces the AI Research Metrics Model (CAARISMA ® ARMM), a machine learning-based medical device designed to objectively assess aesthetic outcomes in FT patients.</div></div><div><h3>Methods</h3><div>Overall, 14 FT patients were analyzed using CAARISMA ® ARMM, which evaluates 3 key aesthetic indices: the Facial Youthfulness Index (FYI), Facial Aesthetic Index (FAI), and Skin Quality Index (SQI). Preoperative, postoperative, and pre-trauma images were processed to assess improvements in facial aesthetics. Statistical analysis was performed to compare changes in these indices across the different time points.</div></div><div><h3>Results</h3><div>Postoperative scores for FYI, FAI, and SQI were significantly higher than preoperative scores (<em>p</em> &lt; 0.0001), indicating substantial aesthetic improvements. No significant differences were found between postoperative and pre-trauma images, suggesting that FT can effectively restore a patient's pre-injury appearance. Aesthetic improvements were consistent across different age and gender groups, with no notable disparities in outcomes.</div></div><div><h3>Conclusion</h3><div>CAARISMA ® ARMM offers a reliable and objective framework for objectifying aesthetic outcomes following FT, allowing for more standardized assessments. This medical device can potentially improve patient-surgeon communication, enhance surgical planning, and serve as a benchmark for evaluating long-term aesthetic success in FT patients. Future research should focus on expanding CAARISMA ® ARMM's application to larger and more diverse patient populations.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102277"},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic analysis of mixed lineage kinase domain-like pseudokinase (MLKL) in oral squamous cell carcinoma: A comparative evaluation between young and old patients","authors":"Reshma Poothakulath Krishnan ,&nbsp;Deepak Pandiar ,&nbsp;Selvaraj Jayaraman ,&nbsp;Pratibha Ramani","doi":"10.1016/j.jormas.2025.102279","DOIUrl":"10.1016/j.jormas.2025.102279","url":null,"abstract":"<div><h3>Background</h3><div>Oral squamous cell carcinoma (OSCC) is characterized by dysregulation of multiple cell signaling pathways, including the necroptotic pathway. Recently, the incidence of OSCC is increasing among the young population (below the age of 40 years). These patients exhibit differences in the pathobiological characteristics and treatment response compared to the older cohorts. There is a notable lack of research exploring the role of necroptotic proteins in younger OSCC patients.</div></div><div><h3>Aim</h3><div>To investigate the expression of Mixed Lineage Kinase domain Like Pseudokinase (MLKL), a key necroptotic protein, in young and old patients with OSCC.</div></div><div><h3>Methodology</h3><div>The study included sixty histopathologically confirmed cases of OSCC, categorized into two groups; Group I - 30 patients aged &gt; 40 years and Group II – 30 patients aged ≤ 40 years. Each of these groups consisted of 10 cases each of well differentiated, moderately differentiated and poorly differentiated OSCC. The samples were evaluated for the MLKL gene expression using Real time PCR and the results were analyzed using the 2−ΔΔCT method.</div></div><div><h3>Results</h3><div>The real-time PCR analysis showed a 31 % decrease in MLKL gene expression in the younger age group (Group II) compared to the older group. A decrease of 40 % in WDSCC, 67 % in MDSCC, and 38 % in PDSCC was observed in the younger group compared to the older age group.</div></div><div><h3>Conclusion</h3><div>Our findings suggest age-related differences in necroptotic cell death regulation through MLKL, with decreased MLKL expression observed in younger patients compared to older patients. Modulating necroptotic cell death pathways in OSCC can promote switching between different cell death pathways and provide effective therapeutic strategies.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102279"},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National survey on implantation practices for free bone flaps: Key findings and insights","authors":"Sophie Dugast ,&nbsp;Leonor Guilmault ,&nbsp;Isabelle Bouhier ,&nbsp;Olivier Airaudo ,&nbsp;Julie Longis ,&nbsp;Helios Bertin","doi":"10.1016/j.jormas.2025.102271","DOIUrl":"10.1016/j.jormas.2025.102271","url":null,"abstract":"<div><h3>Background</h3><div>In cervico-facial oncology, reconstructive procedures aim to ensure patient survival, restore orofacial functions, and maintain esthetic outcomes. The ultimate goal of these interventions is to provide functional rehabilitation. However, dental rehabilitation following bone-free flap reconstructions remains underutilized. This study evaluates current practices in France and identify the challenges reconstructive surgeons face in implementing dental implant rehabilitation after free bone flap reconstruction in an oncological setting.</div></div><div><h3>Methods</h3><div>A nationwide survey was conducted across 52 French hospitals to assess practices related to free bone flap reconstructions and dental implant rehabilitation. An online questionnaire collected data on the epidemiology, rehabilitation practices, team organization, and willingness towards increasing the number of rehabilitated patients following oncological surgeries.</div></div><div><h3>Results</h3><div>Nineteen centers responded, highlighting diverse practices. While most centers perform over 20 free bone flap reconstructions annually, the number of patients receiving implants post-reconstruction was relatively low, with most centers reporting between one and five implant procedures in the past year. Key obstacles to implant rehabilitation included patient irradiation (61 %), lack of financial support (61 %), absence of a practitioner network (50 %), insufficiently trained team members (33 %), risk of oncological recurrence (28 %), extended operating times for primary implantations (22 %), and difficulties with radiological follow-up due to artifacts (17 %)</div></div><div><h3>Conclusion</h3><div>Despite its potential to enhance patient quality of life, dental implant rehabilitation in oncological patients remains marginal in France. This study highlights the need for standardized protocols and improved collaboration between reconstructive surgeons and dental specialists to increase the rate of rehabilitation following free bone flap reconstructions.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102271"},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of miR-141 overexpression on apoptosis and proliferation in Tscca and Tca8113 Cell Lines","authors":"Tao Huang ,&nbsp;Bo Shao ,&nbsp;Zhong-Cheng Gong","doi":"10.1016/j.jormas.2025.102270","DOIUrl":"10.1016/j.jormas.2025.102270","url":null,"abstract":"<div><div>This study investigates the effect of <em>miR-141</em> overexpression on the proliferation and apoptosis of tongue squamous cell carcinoma (TSCC) cell lines (Tscca and Tca8113). TSCC cells were stably transfected with a <em>miR-141</em> lentivirus (Ubi-<em>miR-141</em>-SV40-EGFP-IRES-puromycin, <em>miR-141</em> group) or an empty vector (Ubi-MCS-SV40-EGFP-IRES-puromycin, miR-NC group), with untreated cells serving as the Blank group. <em>miR-141</em> expression was evaluated by rt-qPCR, transfection efficiency and apoptosis were assessed by flow cytometry, and cell proliferation was measured using the CCK-8 assay. Western blot and rt-qPCR were used to analyze the protein and mRNA expression of phosphatase and tensin homolog (PTEN) and B-cell lymphoma-2 (BCL2). Results: Flow cytometry confirmed successful establishment of stably transfected cell lines. The CCK-8 assay showed no significant difference in proliferation between the miR-NC and Blank groups (<em>P</em> &gt; 0.05), while proliferation was significantly reduced in the <em>miR-141</em> group. Apoptosis was significantly higher in the <em>miR-141</em> group compared to both the miR-NC and Blank groups. Western blot and rt-qPCR analyses revealed upregulation of <em>pten</em> gene and PTEN protein expression, as well as downregulation of <em>bcl2</em> gene and BCL2 protein expression in the <em>miR-141</em> group relative to the miR-NC and Blank groups. Conclusion: In TSCC cells with high <em>miR-141</em> expression, <em>pten</em> gene and PTEN protein levels were elevated, while <em>bcl2</em> gene and BCL2 protein levels were reduced. These findings indicate that <em>miR-141</em> may regulate the expression of PTEN and BCL2 at both the gene and protein levels, thereby influencing cell proliferation, migration, and apoptosis. To our knowledge, this is the first study to explore the effects of <em>miR-141</em> transfection in TSCC, providing valuable insights into its role in tumor progression and potential regulatory targets.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102270"},"PeriodicalIF":1.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT, and systematic review ideas to oral and maxillofacial surgeons: Comment","authors":"Hinpetch Daungsupawong,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.jormas.2024.102000","DOIUrl":"10.1016/j.jormas.2024.102000","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102000"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of preoperative psychiatric intervention for postoperative delirium after major oral and maxillofacial surgery with free flap reconstruction","authors":"Yukie Nitta ,&nbsp;Takuro Sanuki ,&nbsp;Shigekazu Sugino ,&nbsp;Masahiro Sugimoto ,&nbsp;Kanta Kido","doi":"10.1016/j.jormas.2024.102026","DOIUrl":"10.1016/j.jormas.2024.102026","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative delirium (POD) is a severe complication associated with various adverse outcomes, especially in older patients. Although the incidence and risk factors for POD have been explored in general surgery, they have not been fully elucidated. Early identification of high-risk patients and active preoperative intervention are considered essential for the prevention of POD. Recently, psychiatric consultation intervention have been shown to prevent delirium. This study investigated the effect of preoperative psychiatric interventions on preventing POD in our specific surgical context.</div></div><div><h3>Materials and Methods</h3><div>This retrospective, single-center observational study included 86 patients who underwent major oral and maxillofacial surgery with free flap reconstruction between 2016 and 2023. The effect of psychiatric intervention were compared between patients with and without delirium.</div></div><div><h3>Results</h3><div>Preoperative psychiatric intervention did not reduce the incidence of POD. The incidence of POD was 29.1 %. Univariate analyses showed no significant associations between POD and any clinical variables.</div></div><div><h3>Conclusion</h3><div>There was no difference in the incidence of POD between patients who received preoperative psychiatric intervention and those who did not, and further investigation is needed to determine the efficacy of preoperative psychiatric intervention in the prevention of POD.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 1","pages":"Article 102026"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}