鉴定来自铁中毒相关基因的新特征以预测头颈部鳞状细胞癌的预后、免疫景观和化疗敏感性。

IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Yuhan Wang , Miao Yu , Pin Lv , Ruoyuan Li , Xiang Wu , Yaping Wu
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引用次数: 0

摘要

背景:在包括头颈部鳞状细胞癌(HNSCC)在内的各种人类恶性肿瘤中,铁下垂抵抗越来越被认为是肿瘤发生、进展和治疗耐药的不可或缺的因素。在此,我们试图利用凋亡相关基因(FRGs)开发一种新的标记,用于HNSCC的预后和治疗预测。方法:采用单因素Cox回归和lasso惩罚多因素Cox回归分析,建立特异性的HNSCC预后特征。通过多变量Cox回归创建了包含该特征和选定临床病理因素的nomogram。FRG标记在预测肿瘤突变负荷(TMB)、免疫状态和化疗反应方面的有效性也进行了评估。结果:基于8个基因(AURKA、LPIN1、MIOX、CDKN2A、PRKAA2、CISD2、TRIB3和ASNS)的FRG特征成功地将患者分为亚组,在多个队列中具有不同的结果。构建了预后良好的FRG图。此外,较高的FRG特征评分与TMB呈正相关,与肿瘤浸润免疫细胞负相关,这与对几种化疗药物的敏感性有关。结论:我们的研究结果提供了强有力的证据,证明frg衍生的特征/图可以有效预测HNSCC的预后和治疗反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of a novel signature derived from ferroptosis-related genes to predict prognosis, immune landscape and chemotherapeutic sensitivity in head and neck squamous cell carcinoma

Background

Ferroptosis resistance is increasingly appreciated as an indispensable factor for tumor initiation, progression, and therapeutic resistance in various human malignancies including head and neck squamous cell carcinoma (HNSCC). Herein, we sought to develop a novel signature utilizing ferroptosis-related genes (FRGs) for prognosis and therapeutic prediction in HNSCC.

Methods

A prognostic signature specific to HNSCC was developed using univariate Cox regression and LASSO-penalized multivariate Cox regression analyses. A nomogram incorporating this signature and selected clinicopathological factors was created through multivariate Cox regression. The effectiveness of the FRG signature in predicting tumor mutation burden (TMB), immune status, and responses to chemotherapy was also evaluated.

Results

The FRG signature based on eight genes (AURKA, LPIN1, MIOX, CDKN2A, PRKAA2, CISD2, TRIB3, and ASNS) successfully classified patients into subgroups with distinct outcomes across multiple cohorts. A FRG nomogram was constructed with good-prognostic performance. Additionally, higher FRG signature scores were positively associated with TMB and negatively correlated with tumor-infiltrating immune cells, which were linked to sensitivity to several chemotherapeutic drugs.

Conclusions

Our findings provide strong evidence that the FRG-derived signature/nomogram can effectively predict both prognosis and therapeutic response in HNSCC.
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来源期刊
Journal of Stomatology Oral and Maxillofacial Surgery
Journal of Stomatology Oral and Maxillofacial Surgery Surgery, Dentistry, Oral Surgery and Medicine, Otorhinolaryngology and Facial Plastic Surgery
CiteScore
2.30
自引率
9.10%
发文量
0
审稿时长
23 days
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