Evaluation of stromal mucin expression in oral submucous fibrosis and its progression to oral squamous cell carcinoma.

IF 2.2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-05-16 DOI:10.1016/j.jormas.2025.102408

Sujitha A, Pratibha Ramani, Suvarna K Nair

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引用次数: 0

Abstract

Introduction: Oral potentially malignant conditions (OPMDs) are abnormalities in the oral mucosa linked to a higher chance of developing oral cancer. Oral submucous fibrosis (OSMF) is a chronic condition causing tissue fibrosis, collagen deposition, and scar tissue production. The highest prevalence of OSMF is reported in Southeast Asian countries, with areca nut consumption being a significant factor.

Materials and methods: This retrospective study involved 20 histopathologically confirmed cases: 10 of oral submucous fibrosis (OSMF) and 10 of oral squamous cell carcinoma (OSCC) arising in the background of OSMF. Alcian blue staining was used to evaluate stromal mucin expression. The Pearson Chi-Square test assessed the relationship between mucin expression and disease progression.

Results: A progressive increase in mucin expression was observed in OSMF-OSCC cases compared to OSMF. Alcian Blue staining revealed 35 % no expression and 15 % low expression in OSMF, while 35 % had low expression and 15 % had moderate expression in OSMF-OSCC cases. The chi-square test yielded a value of 13.3 (df = 2), with a corrected p-value of 0.003, indicating statistical significance.

Conclusion: Alcian Blue staining suggests a trend of increasing mucin expression during malignant transformation. While not a definitive malignancy marker, it may serve as a useful adjunct in histopathological grading. Further studies with larger cohorts and standardized mucin quantification are recommended.

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口腔黏膜下纤维化中基质粘蛋白的表达及其向口腔鳞状细胞癌的进展。

口腔潜在恶性疾病（OPMDs）是口腔黏膜的异常，与发展为口腔癌的更高机会有关。口腔黏膜下纤维化（OSMF）是一种引起组织纤维化、胶原沉积和瘢痕组织产生的慢性疾病。据报道，东南亚国家的OSMF患病率最高，槟榔果消费是一个重要因素。材料和方法：本回顾性研究纳入了20例组织病理学证实的病例，其中10例为口腔黏膜下纤维化（OSMF）， 10例为口腔粘膜下纤维化背景下发生的口腔鳞状细胞癌（OSCC）。阿利新蓝染色检测间质粘蛋白表达。Pearson卡方检验评估粘蛋白表达与疾病进展之间的关系。结果：与OSMF相比，OSMF- oscc中黏蛋白表达呈进行性增加。阿利新蓝染色显示OSMF中35%无表达，15%低表达，OSMF- oscc中35%低表达，15%中表达。卡方检验结果为13.3 (df = 2)，校正p值为0.003，具有统计学意义。结论：阿利新蓝染色提示恶性转化过程中粘蛋白表达有增加的趋势。虽然不是明确的恶性肿瘤标记，但它可以作为组织病理学分级的有用辅助。建议进一步研究更大的队列和标准化的粘蛋白定量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.