Aging Male最新文献

{"title":"Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study.","authors":"Xiwen Liu, Lixuan Lin, Qi Cai, Caichen Li, Haoxiang Xu, Ruiqi Zeng, Mingtong Zhang, Xinyi Qiu, Shiqi Chen, Xizhe Zhang, Linchong Huang, Wenhua Liang, Jianxing He","doi":"10.1080/13685538.2023.2261524","DOIUrl":"10.1080/13685538.2023.2261524","url":null,"abstract":"<p><p>Using Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichment analyses of single nucleotide polymorphisms (SNPs) associated with cancer allowed for a comprehensive bioinformatics approach, which offered a deeper biological understanding of these relationships. The results indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer. Conversely, increased testosterone was linked to lower stomach cancer risk for men, whereas high SHBG levels were related to decreased risks of breast and prostate cancers. The corresponding genes of the identified SNPs, as revealed by pathway enrichment analysis, were involved in significant metabolic and proliferative pathways. These findings emphasize the need for further research into the biological mechanisms behind these associations, paving the way for potential targeted interventions in preventing and treating these cancers.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008.","authors":"Hang Zhou,&nbsp;Mingming Xu,&nbsp;Xuexue Hao,&nbsp;Zhunan Xu,&nbsp;Yang Pan,&nbsp;Xiaoqiang Liu","doi":"10.1080/13685538.2023.2275775","DOIUrl":"10.1080/13685538.2023.2275775","url":null,"abstract":"<p><strong>Background: </strong>The relationship between uric acid (UA) and benign prostatic hyperplasia (BPH) is controversial and has rarely been studied in American populations.</p><p><strong>Methods: </strong>Data from two cycles of the National Health and Nutrition Examination Surveys, comprising data from 2005 to 2008, were used. The majority of BPH were identified by self-report. We investigated the relationship between UA and BPH using univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>2,845 participants were enrolled in the study, including 531 participants with BPH and 2,314 controls. After fully adjusting for all confounders, the risk of developing BPH was reduced by 18% for every 100 μmol/L increase in UA (OR = 0.82, 95% CI: 0.69-0.97, <i>p</i> = 0.023). Participants in the highest quartile of UA were found to have a reduced likelihood of developing BPH (OR_Q4vs1 = 0.61, 95% CI: 0.41-0.91) in comparison to those in the lowest quartile of UA. Subgroup analyses found that among those younger than 60 years, non-Hispanic whites, former smokers, heavy drinkers, those without diabetes, or those with hypertension, high UA remained negatively associated with BPH.</p><p><strong>Conclusions: </strong>The above results suggest that UA may be a potential protective factor for BPH, but the mechanism needs to be further explored.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenic obesity is not associated with sexual dysfunction in older adults: a cross-sectional study.","authors":"Filiz Demirdağ,&nbsp;Burcu Kıvrak Güçer,&nbsp;Esma Nur Kolbaşı","doi":"10.1080/13685538.2023.2252502","DOIUrl":"10.1080/13685538.2023.2252502","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the frequency of sexual dysfunction (SD) and the association between SD and body composition abnormalities, such as sarcopenia, obesity, and sarcopenic obesity.</p><p><strong>Methods: </strong>Older adults (≥65 years) were included. Sarcopenic obesity was diagnosed by using newly defined ESPEN-EASO diagram. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People criteria. Obesity was defined using the fat percentile cut-offs suggested by ESPEN-EASO. SD was determined by Arizona Sexual Experience Scale (ASEX).</p><p><strong>Results: </strong>Two-hundred and sixty-seven volunteers (64.4% female, mean age 73.63 ± 6.22 years) participated in this study. One-hundred seventy-eight individuals (66.7%) had SD. It was present in 83.1% and 36.8% of the females and males, respectively (<i>p</i> < 0.0001). There was no association between SD and sarcopenia alone (OR: 1.359, 95% CI: 0.650-2.838, <i>p</i> = 0.415) or obesity alone (OR: 0.986, 95% CI: 0.543-1.791, <i>p</i> = 0.963). Sarcopenic obesity was significantly associated with SD (OR: 9.116, 95% CI: 1.173-70.851, <i>p</i> = 0.035). However, this significance was lost after the model was adjusted for gender, marital status, and comorbidities (OR: 4.676, 95% CI: 0.578-37.801, <i>p</i> = 0.148).</p><p><strong>Conclusions: </strong>SD was present in 66.7% of the older adults and was not associated with sarcopenia, obesity, or sarcopenic obesity. Further longitudinal studies are needed on this topic.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between depressive mood and subjective health in centenarians and near-centenarians: a cross-sectional study from Korean centenarian cohort.","authors":"Min Jhon,&nbsp;Min-Ho Shin,&nbsp;Kyung Chul Yoon,&nbsp;Jeong-Sun Kim,&nbsp;Jeonghwa Lee,&nbsp;Kwangsung Park,&nbsp;Sang Chul Park","doi":"10.1080/13685538.2023.2257302","DOIUrl":"10.1080/13685538.2023.2257302","url":null,"abstract":"Abstract Background With the rapid increase in population longevity, more clinical attention is being paid to the overall health of long-lived people, especially centenarians. Subjective health, which is the perception of one’s health status, predicts both mortality and declining physical function in older adults. The purpose of this study was to investigate the factors related to subjective health among centenarians and near-centenarians (ages ≥95) living in a rural area of South Korea. Methods A total of 101 participants were enrolled from four different regions (Gurye, Gokseong, Sunchang, and Damyang), known as the Longevity Belt in Korea. Variables assessing physical and mental health, including the results of blood tests, were examined. Factors associated with good subjective health were identified with logistic regression analysis. Results Fifty-six participants (59.6%) were subjectively healthy among the centenarians and near-centenarians. Logistic regression analysis revealed that depressive mood was the only factor associated with subjective health and was negatively correlated. The regression model explained 39% of the variance in subjective health. Conclusions These findings emphasize the importance of mental health at very advanced ages. Because depressive mood negatively correlates with subjective health, more attention is needed to prevent and manage mood symptoms of people of advanced ages, including centenarians.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced sleep duration increases the risk of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in middle-aged and elderly males: a national cross-sectional study.","authors":"Yang Xiong,&nbsp;Yangchang Zhang,&nbsp;Fuxun Zhang,&nbsp;Changjing Wu,&nbsp;Feng Qin,&nbsp;Jiuhong Yuan","doi":"10.1080/13685538.2022.2079627","DOIUrl":"https://doi.org/10.1080/13685538.2022.2079627","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) remains high in men. However, whether reduced sleep duration enhances the risk of LUTS/BPH remains unknown.</p><p><strong>Materials and methods: </strong>The 2015 China Health and Retirement Longitudinal Study was used in this study. Binary logistic regression was adopted to test the relationship between sleep duration and LUTS/BPH. Restricted cubic spline (RCS) regression was used to examine the non-linear association. In sensitivity analyses, propensity scores matching was performed to verify the robustness of the results.</p><p><strong>Results: </strong>In this study, 8,920 males aged 40 years above were enrolled. In the fully adjusted logistic model, across the quartiles of sleep duration, the odds ratios of LUTS/BPH were 1.00 (reference), 0.94 (95% CI 0.77-1.15), 0.74 (95% CI 0.58-0.94), 0.54 (0.37-0.75), respectively. The results of RCS indicated a non-linear inverted U-shaped association between sleep duration and LUTS/BPH (<i>p</i> for non-linearity <0.05). In the subgroup analyses, no significant effects of settlements, alcohol and cigarette consumption, depression, and hypertension on the association between sleep duration and prevalent LUTS/BPH were observed (<i>p</i> for interaction >0.05).</p><p><strong>Conclusion: </strong>Reduced sleep duration is significantly associated with the increases of the LUTS/BPH risk in Chinese middle-aged and elderly males.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Androgen-deprivation therapy and risk of death from cardio-vascular disease in prostate cancer patients: a nationwide lithuanian population-based cohort study.","authors":"Justinas Jonušas,&nbsp;Mingailė Drevinskaitė,&nbsp;Aušvydas Patašius,&nbsp;Marius Kinčius,&nbsp;Ernestas Janulionis,&nbsp;Giedrė Smailytė","doi":"10.1080/13685538.2022.2091130","DOIUrl":"https://doi.org/10.1080/13685538.2022.2091130","url":null,"abstract":"<p><p><b>Purpose:</b> The main purpose of this study was to evaluate the risk of CVD mortality in the national cohort of patients diagnosed with prostate cancer and treated with ADT compared with the ADT non-users.<b>Materials and methods:</b> We performed a retrospective cohort study of patients aged 40-79 years and diagnosed with prostate cancer between 1 January 2012 and 31 December 2016 using the Lithuanian Cancer registry data. In total, 13 343 prostate cancer patients were included in the final study cohort who exclusively used gonadotropin-releasing hormone agonists. The primary outcomes that were registered during the follow-up of this study were overall CVD death.<b>Results:</b> There was a higher risk of CVD death in the cohort of patients treated with ADT than in ADT non-users (HR 2.14, 95% CI [1.86-2.45], <i>p</i> < 0.001). Moreover, there was an increased risk of death from ischemic heart disease and stroke (HR 1.42, 95% CI [1.16-1.73] and 1.70, 95% CI [1.18-2.45], respectively) among ADT users. Finally, the risk of CVD-related mortality was highest in the 70-79 age group of ADT users (HR 4.78, 95% CI [3.79-6.04]).<b>Conclusions:</b> This study shows that ADT usage is associated with increased CVD-related mortality risk for patients diagnosed with prostate cancer compared with ADT non-users. The highest mortality risk was found for ischemic heart disease and stroke. CVD-related mortality was increased in the elder group of patients also.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40625542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary fibrous tumors in prostate: a case report with review of the literature.","authors":"Yueqiang Peng,&nbsp;Yu Jiang,&nbsp;Siwei Ding,&nbsp;Yongbo Zheng,&nbsp;Wei Tang,&nbsp;Jiayu Liu","doi":"10.1080/13685538.2022.2110232","DOIUrl":"https://doi.org/10.1080/13685538.2022.2110232","url":null,"abstract":"<p><strong>Background: </strong>Solitary fibrous tumor (SFT) is a relatively rare type of mesenchymal neoplasm that occurs most frequently in the pleura. However, SFT originating from the prostate is particularly uncommon and only approximately 39 cases were reported before. Herein, we reported a rare case of a patient diagnosed with prostate SFT and presented a literature review.<b>Case presentation</b>: A 50-year-old Asian with irritative urinary symptoms was admitted to our hospital and almost all the evidence indicated that benign prostate hyperplasia (BPH) caused his symptoms. Therefore, transurethral resection of the prostate (TURP) was performed, but histopathological and Immunohistochemical (IHC) assessments showed that spindle cells arranged disorderly in the TURP specimen with a cluster of differentiation 34 (CD34), B-cell lymphoma-2 (Bcl-2), and signal transducer and activator of transcription 6 (STAT6) highly expressed and SFT was diagnosed. Finally, the patient underwent a radical prostatectomy and there was no disease progression observed thereafter.</p><p><strong>Conclusions: </strong>Prostate SFT is extremely rare, and to our knowledge, this is the first case of prostate SFT that is difficult to differentiate from small volume BPH. IHC examinations are of great diagnostic value. Radical resection of the tumor appears to be the most effective method at present and continuous follow-up is highly recommended.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40643351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erectile dysfunction: the non-utilized role of exercise rehabilitation for the most embarrassing forgotten post-COVID complication in men.","authors":"Ali Mohamed Ali Ismail","doi":"10.1080/13685538.2022.2108013","DOIUrl":"https://doi.org/10.1080/13685538.2022.2108013","url":null,"abstract":"For good subjective wellbeing and quality of life (QoL), a good penile erection is an important cornerstone for normal sexual activity in men [1]. Erectile dysfunction (ED), the inability to achieve and/or maintain a penile erection sufficient for successful vaginal intercourse for satisfactory sexual performance or penetration [2], develops psychological disorders that decreases the man’s confidence and his QoL [1]. Recently, according to published literature, many body organs/structures express their post-COVID dysfunctions. ED is one of the most silent/embarrassing residual postCOVID complications in men [3]. At the same time that patients with COVID-19 were 3.3 times more likely to have ED [4], great attention and research are directed toward other post-COVID complications such as dyspnea, limited physical capacity, fatigue, poor sleepiness, etc. The majority of evidence points to COVID-19’s participation in the ED, however, the exact pathophysiology has yet to be thoroughly understood. COVID-19 infection may disrupt male sexual function by causing endothelium damage in erectile tissue, testicular injury, psychological changes [5]. In this domain, the concept of sexual long COVID may raise. Symptoms/complications of long COVID that affect many systems including the respiratory system (dyspnea and pulmonary fibrosis), cardiovascular system (myocarditis and endothelial dysfunction), and endocrine system (thyroid dysfunctions, diabetes, or hypogonadism) may impair erectile function in COVID-19 long haulers [6]. SARS-CoV-2 viral particles have been found in penile and testicular tissue, both in living COVID-19 patients who recovered and in males who died from the COVID condition. SARS-CoV-2 can directly damage cavernosal endothelium, resulting in male sexual dysfunction, as evidenced by the virus’s persistence in penile tissue up to 7 months after infection [7]. Lifestyle changes/interventions [8], including exercise, share the first-line treatment approach for ED with inhibitors of phosphodiesterase type 5 [9]. Despite calls for regular supervised exercise to reduce post-COVID complications (such as dyspnea, reduced physical capacity, mood disturbances, poor sleepiness, muscle weakness, cardiovascular risk, etc.) [10], post-COVID-induced ED is not among them. One of the evidence-based effects of exercise is modifying/correcting endothelial dysfunction [11], the main suspect in the occurrence of ED caused by COVID [12]. Exercise improves circulating levels of nitric oxide (increases vasodilation within penile vessels), hormonal/ chemical compounds that relax penile arterial walls, and free radicals (toxic and destructive substances that contribute to endothelial injury of penile vessels) [13]. Another evidence-based effect of exercise is improving immune system functions. The following are the proposed mechanisms of exercise-improving post-COVID immunity: (a) raising the amount and activity of T-lymphocytes, neutrophils, macrophages, and monocyte","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40706547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary, secondary and compensated male biochemical hypogonadism in people living with HIV (PLWH): relevance of sex hormone-binding globulin (SHBG) measurement and comparison between liquid chromatography-tandem mass spectrometry (LC-MS/MS) and chemiluminescent immunoassay for sex steroids assay.","authors":"Sara De Vincentis,&nbsp;Maria Chiara Decaroli,&nbsp;Flaminia Fanelli,&nbsp;Chiara Diazzi,&nbsp;Marco Mezzullo,&nbsp;Giulia Tartaro,&nbsp;Simonetta Tagliavini,&nbsp;Maria Cristina De Santis,&nbsp;Laura Roli,&nbsp;Jovana Milic,&nbsp;Tommaso Trenti,&nbsp;Uberto Pagotto,&nbsp;Giovanni Guaraldi,&nbsp;Vincenzo Rochira","doi":"10.1080/13685538.2022.2039116","DOIUrl":"https://doi.org/10.1080/13685538.2022.2039116","url":null,"abstract":"<p><strong>Background: </strong>Data about classification of hypogonadism and estrogen deficiency in male people living with HIV (PLWH) are scanty.</p><p><strong>Aim: </strong>To investigate the prevalence and characterization of biochemical hypogonadism and relative estrogen deficiency in male PLWH aged < 50 comparing liquid chromatography-tandem mass spectrometry (LC-MS/MS) with chemiluminescent immunoassay (CI), and combining gonadotropin, sex hormone-binding globulin (SHBG) and serum estradiol (E2) measurements.</p><p><strong>Methods: </strong>Prospective, cross-sectional, observational study. Serum total testosterone (TT), E2, gonadotropins, SHBG were measured by CI. TT and E2 were also assessed by LC-MS/MS. Free testosterone (cFT) was calculated by Vermeulen equation.</p><p><strong>Results: </strong>A total of 316 PLWH (45.3 ± 5.3 years) were enrolled. TT and cFT by LC-MS/MS were lower compared to CI (<i>p</i> < 0.0001). The prevalence of biochemical hypogonadism was higher with LC-MS/MS than CI, both for TT (5.1% vs 3.2%, <i>p</i> < 0.0001) or cFT (9.5% vs 7%, <i>p</i> < 0.0001). The prevalence of hypogonadism (overt + compensated) was 17.1% for cFT using LC-MS/MS. Secondary form of hypogonadism was more prevalent than primary. The prevalence of relative estrogen deficiency was of 30.0% among hypogonadal patients and 15.5% among eugonadal.</p><p><strong>Conclusions: </strong>The prevalence of male hypogonadism results underestimated by CI compared to LC-MS/MS in PLWH, both for TT and cFT. SHBG and gonadotropins are essential for detecting T deficiency.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40315796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of impaired grip strength and gait function with the severity of erectile dysfunction in men undergoing dialysis: a cross-sectional study.","authors":"Naoki Fujita,&nbsp;Shingo Hatakeyama,&nbsp;Masaki Momota,&nbsp;Yuki Tobisawa,&nbsp;Tohru Yoneyama,&nbsp;Teppei Okamoto,&nbsp;Hayato Yamamoto,&nbsp;Takahiro Yoneyama,&nbsp;Yasuhiro Hashimoto,&nbsp;Kazuaki Yoshikawa,&nbsp;Chikara Ohyama","doi":"10.1080/13685538.2021.2016690","DOIUrl":"https://doi.org/10.1080/13685538.2021.2016690","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the associations of impaired muscle strength and gait function with the severity of erectile dysfunction (ED) in men undergoing dialysis.</p><p><strong>Methods: </strong>This cross-sectional study included 63 men undergoing dialysis. ED was assessed with the Sexual Health Inventory for Men (SHIM). Patients were divided into the mild/moderate (SHIM score ≥8) and severe ED groups (SHIM score ≤7). Correlations between variables were analyzed using Spearman's rank correlation coefficient. Multivariable logistic regression analyses were performed to evaluate the impact of impaired grip strength and gait function on the severity of ED.</p><p><strong>Results: </strong>The median age of the study participants was 62 years; all had ED, with 67% having severe ED. Spearman's rank correlation test demonstrated significant negative and positive correlations between gait function and SHIM score (<i>ρ</i> = -0.257, <i>p</i> = 0.042) and between grip strength and SHIM score (<i>ρ</i> = 0.305, <i>p</i> = 0.015), respectively. In the multivariable analyses, impaired grip strength was significantly associated with severe ED (odds ratio [OR]: 4.965, <i>p</i> = 0.017), whereas gait function was not (OR: 3.147, <i>p</i> = 0.064).</p><p><strong>Conclusion: </strong>Impaired muscle strength was significantly associated with severe ED, whereas impaired gait function had a marginal effect on this erectile condition.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}