Aging Male最新文献

{"title":"PhenoAgeAccel mediates the association between metabolic syndrome and cancer risk in males: a cross-sectional NHANES study.","authors":"Jiaxiang Yang, Yingzhe Zhang, Puhua Zeng, Xiaolan Jian","doi":"10.1080/13685538.2026.2612796","DOIUrl":"10.1080/13685538.2026.2612796","url":null,"abstract":"<p><strong>Background: </strong>The relationship between metabolic syndrome (MetS) and cancer risk, and the potential mediating role of biological aging as measured by Phenotypic Age Acceleration (PhenoAgeAccel), remains insufficiently characterized.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 12,664 participants from the National Health and Nutrition Examination Survey (NHANES, 1999-2010, 2015-2020). MetS was defined according to established criteria, cancer status was self-reported, and PhenoAgeAccel was derived from clinical biomarkers. Weighted multivariable logistic regression and formal causal mediation analysis were employed.</p><p><strong>Results: </strong>After full adjustment, MetS was significantly associated with increased cancer prevalence (OR = 1.338, 95% CI: 1.074-1.666, <i>p</i> = 0.010). This association was more pronounced in males (OR = 2.383, <i>p</i> < 0.05) and adults aged 20-65 years (OR = 1.573, <i>p</i> < 0.05). Mediation analysis revealed that PhenoAgeAccel significantly accounted for 16.5% of the total effect of MetS on cancer (Average Causal Mediation Effect = 0.00352, <i>p</i> < 0.001). Gender stratification indicated a statistically significant mediating effect in males (proportion mediated = 10.9%, <i>p</i> = 0.002) but not in females (proportion mediated = 10.9%, <i>p</i> = 0.086). The direct effect of MetS remained significant (OR = 1.265, <i>p</i> = 0.050).</p><p><strong>Conclusion: </strong>MetS is associated with elevated cancer risk, with PhenoAgeAccel serving as a significant mediating pathway, particularly among males. These findings identify younger males as a high-risk subgroup for targeted preventive strategies.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2612796"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitination-anchored signature defines neuroendocrine prostate cancer: hub genes and single-cell ecosystem insights from integrated bioinformatics analysis of public transcriptomic datasets.","authors":"Zhenkun Zhao, Lei Qiu, Ziang Li, Jialong Wu, Qianyang Ni, Sijie Li, Hongyin Wang, Chengdong Shi, Xiushi Lin, Yixiao Liu, Jian Lu","doi":"10.1080/13685538.2026.2680719","DOIUrl":"10.1080/13685538.2026.2680719","url":null,"abstract":"<p><strong>Background: </strong>Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory state that often emerges under androgen-receptor pathway inhibition. We hypothesized that dysregulated ubiquitination underpins NEPC lineage plasticity and that integrating bulk and single-cell transcriptomes would define a ubiquitination-centered signature and tumor microenvironment (TME) circuits of diagnostic and therapeutic relevance.</p><p><strong>Methods: </strong>Public bulk transcriptomic datasets were combined to compare NEPC with prostate adenocarcinoma, including a GEO discovery cohort of 49 tissue samples from GSE32967 and GSE104786, and intersected with a curated ubiquitination-related gene universe to derive ubiquitination-related differentially expressed genes (URDEGs). Co-expression networks, functional enrichment, and protein-protein interaction (PPI) network topology analyses were used to identify and prioritize candidate hub genes. An independent scRNA-seq cohort was integrated for biological contextualization to map cellular lineages, hub gene localization, and intercellular communication.</p><p><strong>Results: </strong>We identified 317 URDEGs that clearly segregated NEPC from conventional prostate cancer and clustered into NEPC-associated modules enriched for cell-cycle and mitotic programs. Network integration yielded an 11-gene hub panel, including AURKA, CCNA2, EZH2, FGFR1, and TTK. In the single-cell dataset, 25,325 cells were retained after quality control, and UMAP resolved 17 clusters annotated into 8 major lineages. Single-cell mapping further revealed lineage-biased hub gene expression and highlighted a prominent stromal-vascular as well as immune MIF-CD74/CXCR4 signaling axis.</p><p><strong>Conclusions: </strong>This integrative analysis identifies a ubiquitination‑anchored transcriptomic signature and associated hub‑gene network that are consistently associated with NEPC in public bulk datasets and supported by cell‑type-resolved patterns in an independent scRNA‑seq cohort; these findings nominate candidate biomarkers and therapeutic hypotheses that warrant external validation in prospectively collected, clinically annotated cohorts with protein‑level assessment.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2680719"},"PeriodicalIF":2.6,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency is associated with higher frailty risk among middle-aged and older adults: a national population-based analysis of NHANES 2007-2018.","authors":"Jiaming Zheng, Qingqing Yang, Lin Dou, Baoqi Zeng","doi":"10.1080/13685538.2026.2749894","DOIUrl":"https://doi.org/10.1080/13685538.2026.2749894","url":null,"abstract":"<p><strong>Background: </strong>Although frailty is common in older adults, the relationship between vitamin D and frailty remains unclear. Using NHANES data, this study examined the association between frailty and serum vitamin D in middle-aged and older adults.</p><p><strong>Methods: </strong>Eight thousand and sixty-four participants aged 40 and older from NHANES (2007-2018) underwent cross-sectional analysis. Serum vitamin D was categorized as deficiency (<25 nmol/L), insufficiency (25-50 nmol/L), or adequate (≥50 nmol/L). Frailty was quantified using a 49-item Frailty Index (FI) based on the cumulative deficit model; frailty was defined as FI ≥ 0.21. Logistic regression and restricted cubic splines were used.</p><p><strong>Results: </strong>The deficiency group had the highest frailty prevalence (55.9%), followed by insufficiency (42.9%) and adequate (37.2%). Frailty was significantly associated with deficiency (OR 2.15, 95% CI 1.42-3.25) after full adjustment, whereas insufficiency was not significantly associated with frailty (OR 1.15, 95% CI 0.95-1.38). Serum vitamin D and FI showed a U-shaped dose-response relationship, robust across subgroup and sensitivity analyses.</p><p><strong>Conclusion: </strong>In middle-aged and older adults, vitamin D deficiency, but not insufficiency, is associated with higher frailty risk. Serum vitamin D may have a U-shaped association with FI. Monitoring vitamin D levels may help inform frailty management in aging populations.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2749894"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A current profile of digital health literacy: patients undergoing holmium laser enucleation of the prostate (HoLEP). Different outcomes with population variation. A new prospective study.","authors":"Alper Coşkun, Mahmut Selman Mert, Yiğit Kudret Akyol, Utku Can, Cengiz Çanakçi, Erdinç Di̇nçer","doi":"10.1080/13685538.2025.2578628","DOIUrl":"10.1080/13685538.2025.2578628","url":null,"abstract":"<p><strong>Background: </strong>Digital health literacy (e-HL) is an increasingly popular analysis of patients' awareness of appropriate treatment modalities. This study aimed to evaluate e-HL levels in men undergoing Holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia (BPH) and its potential impact on their quality of life.</p><p><strong>Methods: </strong>A total of 106 patients scheduled for HoLEP were included. Age, body mass index (BMI), prostate-specific antigen (PSA), prostate volume, preoperative uroflowmetry values, e-HL scores, International Standard Classification of Education (ISCED) levels, and internet usage data were recorded. The EuroQoL Quality of Life (EQ-5D-5L) questionnaire was administered at three months postoperatively. Follow-up uroflowmetry results, IPSS scores, and quality of life (QoL) assessments were compared with e-HL scores. A cutoff value for digital health literacy was identified.</p><p><strong>Results: </strong>The mean age was 68 years, BMI 29.1 kg/m², prostate volume 86.6 cc, and PSA 7.5 ± 4.6 ng/ml. The mean e-HL score was 16.8 ± 9.8, which was negatively correlated with age and BMI, positively with ISCED level and internet use (<i>p</i> < 0.001). The cutoff for adequate e-HL was 18.5. No significant correlation was found between e-HL and postoperative IPSS, EQ-5D-5L scores.</p><p><strong>Conclusion: </strong>e-HL levels in HoLEP patients were not associated with symptom severity, postoperative outcomes, or quality of life. Further multicenter studies are needed.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2578628"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) in erectile dysfunction: an integrated mendelian randomization, network pharmacology, and multi-omics study.","authors":"Yugen Li, Guangqiang Zhu, Chunlin Tan","doi":"10.1080/13685538.2026.2625511","DOIUrl":"10.1080/13685538.2026.2625511","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the causal effect of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) on erectile dysfunction (ED) and elucidated its underlying molecular mechanisms through multi-omics integration.</p><p><strong>Methods: </strong>Mendelian randomization (MR) was applied to evaluate the causal effects of CMPF on ED and metabolic risk factors. Network pharmacology was used to identify overlapping molecular targets, followed by molecular docking to assess binding affinity. Multi-omics validation incorporated Summary-data-based MR (SMR) analyses of expression and protein quantitative trait loci (eQTL/pQTL) to confirm genetically regulated CMPF-related targets.</p><p><strong>Results: </strong>MR analyses demonstrated a protective effect of CMPF on ED in both discovery (OR: 0.78, 95% CI: 0.62-0.98) and replication cohorts (OR: 0.82, 95% CI: 0.69-0.98), along with favorable associations with glucose metabolism, blood pressure, and lipid traits. Network analysis identified 42 shared targets, with DPP4, LGALS3, and NR3C2 as hub targets. Molecular docking showed strong binding affinities (≤-6.0 kcal/mol). SMR analyses highlighted LGALS3 as a key genetic mediator, supported by consistent eQTL and pQTL signals.</p><p><strong>Conclusions: </strong>CMPF exerts protective effects against ED and metabolic dysfunction through multi-target modulation, with LGALS3, DPP4, and NR3C2 as central regulators. These findings support CMPF as a diet-derived bioactive metabolite with potential for nutritional interventions and multi-target therapeutic strategies in ED.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2625511"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the relationship between erectile dysfunction and the ZJU index in US adults: results from NHANES 2001-2004.","authors":"Weiqiang Ning, Sujun Jia, Linjin Li, Dake Chen, Bo Wu","doi":"10.1080/13685538.2026.2627017","DOIUrl":"10.1080/13685538.2026.2627017","url":null,"abstract":"<p><strong>Background: </strong>The ZJU index is a composite metric incorporating triglyceride (TG), fasting plasma glucose (FPG), the alanine aminotransferase (ALT) to aspartate aminotransferase ratio (AST) (ALT/AST), and body mass index (BMI). This study aimed to investigate the relationship between the ZJU index and the risk of erectile dysfunction (ED).</p><p><strong>Methods: </strong>This analysis utilized data from 1,906 participants in the 2001-2004 National Health and Nutrition Examination Survey (NHANES) dataset. We employed logistic regression modeling, smooth curve fitting, subgroup analysis, and threshold effect analysis to evaluate the association between the ZJU index and ED. The missing values in the covariates were filled by multiple interpolation.</p><p><strong>Results: </strong>A significant positive association was observed between the ZJU index and ED risk (OR [95% CI] = 1.03 [1.01,1.05]). Analysis revealed a threshold at a ZJU index of 33.4, above which ED risk increased markedly, while the association was not significant below this value. Subgroup analysis indicated a stronger association in participants under 60 years of age.</p><p><strong>Conclusion: </strong>Higher ZJU index values are positively associated with an increased risk of erectile dysfunction, particularly among individuals under 60 years old. These findings suggest the potential utility of the ZJU index as a screening tool for ED risk assessment.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2627017"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning for individualized survival prediction in node-positive, non-metastatic prostate cancer: a population-based study.","authors":"Erhao Bao, Yucong Chai, Yang Yang, Shangtai Dai, Chongjian Wang, Xiaomao Zhou, Xia Li, Yuchen Li, Qilin Yang, Jing Liu","doi":"10.1080/13685538.2026.2724617","DOIUrl":"https://doi.org/10.1080/13685538.2026.2724617","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer with regional lymph node involvement but no distant metastasis (N1M0) has heterogeneous prognosis. This study aimed to develop and validate an interpretable machine learning model for predicting cancer-specific survival (CSS).</p><p><strong>Methods: </strong>Data from 18,287 N1M0 patients (2000-2022) in the SEER database were divided into training (<i>n </i>= 4780), internal testing (<i>n </i>= 1193), and two temporal validation cohorts (<i>n</i> = 3149; <i>n</i> = 9165). Cox proportional hazards and four machine learning models were compared using C-index, time-dependent AUC, and Integrated Brier Score. SHAP was used for interpretability, and IPTW for sensitivity analysis.</p><p><strong>Results: </strong>Random Survival Forest (RSF) outperformed all models, achieving the highest C-index (0.697 internal; 0.740 temporal validation). RSF-stratified risk groups showed significant survival differences (<i>P </i>< 0.001). SHAP revealed radical prostatectomy as the strongest protective factor, followed by lower T stage and PSA. IPTW confirmed survival benefits of aggressive local control. CSS outperformed overall survival in discriminative accuracy.</p><p><strong>Conclusion: </strong>The RSF model provides accurate, robust, and interpretable prognostication for N1M0 prostate cancer. Deployed as a web-based calculator, it enables precise risk stratification and individualized treatment planning.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2724617"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPISE index and ensemble machine learning refine cardiovascular risk stratification in stage 0-3 CKM syndrome.","authors":"Lin Wang, Hao Wang, Ting Liu, Nianzhu Zhang, Lifen Zhao","doi":"10.1080/13685538.2026.2670021","DOIUrl":"10.1080/13685538.2026.2670021","url":null,"abstract":"<p><strong>Background: </strong>While the single-point insulin sensitivity estimator (SPISE) shows promise as an insulin resistance biomarker, its association with cardiovascular disease (CVD) in early CKM stages (0-3) remains underexplored.</p><p><strong>Methods: </strong>We analyzed 6480 participants with CKM stage 0-3 from the China Health and Retirement Longitudinal Study. CVD outcomes were assessed relative to SPISE index levels. An ensemble machine learning model was employed to predict CVD risk.</p><p><strong>Results: </strong>6480 subjects were enrolled, of whom 967 developed CVD. After stratifying participants into SPISE quartiles (Q1-Q4) and adjusting for covariates, higher quartiles were linked to a lower CVD risk. This study developed an LR+GMM (Logistic Regression + Gaussian Mixture Model) ensemble model to predict CVD risk using five strong predictors: SPISE, high-density lipoprotein cholesterol (HDL-c), diastolic blood pressure (DBP), body mass index (BMI), and glycated hemoglobin (HbA1c). The model performed well, achieving an accuracy (ACC) of 0.986 and an area under the receiver operating characteristic curve (AUC) of 0.932.</p><p><strong>Conclusions: </strong>The SPISE index is a significant inverse predictor of CVD risk in individuals with stage 0-3 CKM syndrome. The LR+GMM ensemble model, incorporating the SPISE index and four clinical metrics, demonstrated outstanding predictive performance.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2670021"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association and shared mechanisms between Graves' disease and prostate cancer: insights from Mendelian randomization, machine learning, and comprehensive bioinformatics.","authors":"Mingshun Zuo, Yuanjian Liao, Qiang Xu, Ailing Su, Ni Fu, Chenghong Zou","doi":"10.1080/13685538.2026.2695558","DOIUrl":"10.1080/13685538.2026.2695558","url":null,"abstract":"<p><strong>Background: </strong>Observational studies link hyperthyroidism to increased prostate cancer (PCa) risk, but causality and mechanisms remain unclear. Graves' disease (GD), the primary cause of hyperthyroidism, involves chronic immune dysregulation that may influence PCa through shared immune pathways.</p><p><strong>Methods: </strong>We performed bidirectional two-sample Mendelian randomization (MR) using IEU Open GWAS data, then integrated differential expression analysis, weighted gene co-expression network analysis (WGCNA), and machine learning on Gene Expression Omnibus (GEO) datasets to identify shared gene, validated by ROC curves, and analyzed immune profilesusing ssGSEA.</p><p><strong>Results: </strong>MR analysis indicated that genetic predisposition to GD significantly reduced PCa risk (OR = 0.997, 95% CI = 0.996-0.999, <i>p </i>= 0.004), with consistentsensitivity and no reverse causality. Four key genes (BTG2, JUN, JUNB, FOS) were identified as robust shared genes with high predictive accuracy in external validation. Immune profiles analysis revealed disease-specific associations of these genes: BTG2 and JUNB correlated with memory CD8 T cells in GD, whereas all four genes correlated with dendritic cells, mast cells and NK cells in PCa.</p><p><strong>Conclusion: </strong>This study provided novel insights into the protective effect of GD against PCa and identified shared genes and immune mechanisms, offering a deeper understanding of the common mechanisms between GD and PCa.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2695558"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram for the overall survival of patients with locally advanced prostate cancer treated with radiotherapy and surgery.","authors":"Bing Zhang, Qingya Yang, Hui Sun, Ming Liu, Hao Liang, Hong Ji","doi":"10.1080/13685538.2025.2609400","DOIUrl":"10.1080/13685538.2025.2609400","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery.</p><p><strong>Methods: </strong>Clinical and pathological information was downloaded from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. The selected patients were randomly divided into a training cohort and a validation cohort at a ratio of 7:3. Univariate, multivariate Cox, and stepwise backward regression analyses were used to identify independent risk factors for OS.</p><p><strong>Results: </strong>A total of 2810 elderly patients with locally advanced PC who received radiotherapy and surgery from 2010 to 2015 were included in this study. Age, marital status, Gleason score, tumor stage were identified as independent risk factors for PC patients. Age and marital status primarily reflect background mortality risk. The nomogram demonstrated favorable discrimination and calibration, with AUCs of 0.676-0.774 for 3-, 5-, and 8-year OS, indicating good predictive performance. Decision curve analysis further confirmed its superior clinical net benefit compared with the traditional tumor-node-metastasis staging model.</p><p><strong>Conclusions: </strong>We developed a new nomogram to predict OS in elderly patients with locally advanced PC treated with radiotherapy and surgery.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2609400"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}