Aging Male最新文献_第5页

Prostate-specific antigen, androgen, progesterone and oestrogen receptors in Benign prostatic hyperplasia: human tissues and animal model study. 良性前列腺增生症中的前列腺特异性抗原、雄激素、孕激素和雌激素受体：人体组织和动物模型研究。

IF 2.7 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1080/13685538.2024.2391380

Haohan Wang, Chengcheng Liu, Ziqiang Dong, Xiaobo Chen, Ping Zhang

{"title":"Prostate-specific antigen, androgen, progesterone and oestrogen receptors in Benign prostatic hyperplasia: human tissues and animal model study.","authors":"Haohan Wang, Chengcheng Liu, Ziqiang Dong, Xiaobo Chen, Ping Zhang","doi":"10.1080/13685538.2024.2391380","DOIUrl":"https://doi.org/10.1080/13685538.2024.2391380","url":null,"abstract":"Background: Direct evidence for the relationship between a large prostate (≥80 ml) and androgen receptor/PSA signal remains lacking in benign prostatic hyperplasia (BPH). Our aim is to identify whether the cause of a large prostate is related to progesterone receptor (PGR) androgen receptor (AR), oestrogen receptor α, β (ERα,β) and prostate-specific antigen (PSA).Materials and methods: Surgical specimens of BPH in plasmakinetic resection of the prostate (PKRP) with three groups of different prostate-sizes with mean volumes of 25.97 ml, 63.80 ml, and 122.37 ml were collected for immunohistochemical analysis of the tissue microarray with PGR, AR, PSA and ERs. Rats were castrated and treated with testosterone replacement to explore androgen and PGR, AR and ERs expression levels in the prostate. Quantitative real-time reverse transcription polymerase chain reaction (Rt-PCR) for mRNA detection of above genes was conducted.Results: Immunoblotting, Rt-PCR and immunohistochemistry assays showed that PGR, PSA, AR, ERα expression levels were positively correlated with prostate size and that ERβ expression levels were negatively correlated with prostate volume. Animal experiments have shown that prostate volume is decreased in castrated rats with decreased PGR, AR, ERα and increased ERβ expression levels.Conclusion: PGR, AR, ERs signals can be regarded as important factors for large-sized prostates in BPH patients (≥100 ml).","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2391380"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular health of fathers with history of intracytoplasmic sperm injection. 有过卵胞浆内单精子注射史的父亲的血管健康状况。

IF 2.7 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI: 10.1080/13685538.2024.2360529

Pengzhu Li, Magdalena Langer, Theresa Vilsmaier, Marie Kramer, Franziska Sciuk, Brenda Kolbinger, André Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer

{"title":"Vascular health of fathers with history of intracytoplasmic sperm injection.","authors":"Pengzhu Li, Magdalena Langer, Theresa Vilsmaier, Marie Kramer, Franziska Sciuk, Brenda Kolbinger, André Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer","doi":"10.1080/13685538.2024.2360529","DOIUrl":"10.1080/13685538.2024.2360529","url":null,"abstract":"Objective: Studies suggest that men who undergo assisted reproductive technologies (ART) may have a higher risk of cardiovascular disease; however, limited data on this matter is available. This observational pilot study aimed to investigate the overall vascular health of fathers with history of intracytoplasmic sperm injection (ICSI) compared to fathers whose partners conceived spontaneously.Methods: Diet quality, physical activity, sedentary behavior as well as overall vascular function including the assessment of pulse wave analysis, intima-media thickness (cIMT), arterial stiffness of the common carotid artery (CCA) and blood lipids, were evaluated.Results: A total of 34 fathers with history of ICSI and 29 controls (48.49 [46.32 - 57.09] years vs. 47.19 [40.62 - 55.18] years, p = 0.061) were included. After adjusting for age, no significantly increased cardiovascular risk was detected regarding vascular function.Conclusions: The results suggest an unaltered cardiovascular risk profile in fathers with history of ICSI. In the future, prospective multicenter studies are required to validate these preliminary results.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2360529"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold. 胰岛素样肽 3 (INSL3) 作为中老年男性性腺功能减退症患者白细胞功能不全 (LCI) 的指标：参考范围和阈值。

IF 2.7 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-04-26 DOI: 10.1080/13685538.2024.2346322

Ravinder Anand-Ivell, Kee Heng, Leen Antonio, Gyorgy Bartfai, Felipe F Casanueva, Mario Maggi, Terence W O'Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick Cw Wu, Ilpo T Huhtaniemi, Richard Ivell

{"title":"Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold.","authors":"Ravinder Anand-Ivell, Kee Heng, Leen Antonio, Gyorgy Bartfai, Felipe F Casanueva, Mario Maggi, Terence W O'Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick Cw Wu, Ilpo T Huhtaniemi, Richard Ivell","doi":"10.1080/13685538.2024.2346322","DOIUrl":"10.1080/13685538.2024.2346322","url":null,"abstract":"Insulin-like peptide 3 (INSL3) is a circulating biomarker for Leydig cell functional capacity in men, also indicating Leydig Cell Insufficiency (LCI) and potential primary hypogonadism. Using results from large cohort studies we explore sources of biological and technical variance, and establish a reference range for adult men. It is constitutively secreted with little within-individual variation and reflects testicular capacity to produce testosterone. The main INSL3 assays available indicate good concordance with low technical variance; there is no effect of ethnicity. INSL3 declines with age from 35 years at about 15% per decade. Like low calculated free testosterone, and to a lesser extent low total testosterone, reduced INSL3 is significantly associated with increasing age-related morbidity, including lower overall sexual function, reflecting LCI. Consequently, low INSL3 (≤0.4 ng/ml; ca. <2 SD from the population mean) might serve as an additional biochemical marker in the assessment of functional hypogonadism (late-onset hypogonadism, LOH) where testosterone is in the borderline low range. Excluding individuals with low LCI (INSL3 ≤ 0.4 ng/ml) leads to an age-independent (> 35 years) reference range (serum) for INSL3 in the eugonadal population of 0.4 - 2.3 ng/ml, with low INSL3 prospectively identifying individuals at risk of increased future morbidity.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2346322"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of COVID-19 on the time to counseling and treatment of prostate cancer. COVID-19 对前列腺癌咨询和治疗时间的影响。

IF 2.6 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-05-07 DOI: 10.1080/13685538.2024.2347465

Dejan K Filipas, Randi M Pose, Phillip Marks, Pierre Tennstedt, Burkhard Beyer, Derya Tilki, Hendrik Isbarn, Tobias Maurer, Tim A Ludwig, Hans Heinzer, Thomas Steuber

{"title":"Impact of COVID-19 on the time to counseling and treatment of prostate cancer.","authors":"Dejan K Filipas, Randi M Pose, Phillip Marks, Pierre Tennstedt, Burkhard Beyer, Derya Tilki, Hendrik Isbarn, Tobias Maurer, Tim A Ludwig, Hans Heinzer, Thomas Steuber","doi":"10.1080/13685538.2024.2347465","DOIUrl":"https://doi.org/10.1080/13685538.2024.2347465","url":null,"abstract":"Purpose: This study investigates how the COVID-19 pandemic (CP) impacted the timeline between initial diagnosis (ID) of prostate carcinoma and subsequent therapy consultation (TC) or radical prostatectomy (RP) due to the implementation of a \"minimal contact concept,\" which postponed clinical examinations until the day of admission.Methods: We analyzed patient data from a tertiary care center from 2018 to September 2021. The focus was on comparing the time intervals from ID to TC and from ID to RP before and during the CP.Results: Of 12,255 patients, 6,073 (61.6%) were treated before and 3,791 (38.4%) during the CP. The median time from ID to TC reduced from 37 days (IQR: 21 - 58d) pre-CP to 32 days (IQR: 20 - 50d) during CP (p < 0.001). Similarly, the time from ID to RP decreased from 98 days (IQR: 70 - 141d) to 75 days (IQR: 55 - 108d; p < 0.001) during the CP. There was a significant decrease in low-risk tumor cases at ID (18.9% vs. 21.4%; p = 0.003) and post-RP (4% vs. 6.7%; p < 0.001) during the CP.Conclusion: Our findings suggest that the COVID-19 pandemic facilitated more timely treatment of prostate cancer, suggesting potential benefits for both low-risk and aggressive tumor management through expedited clinical procedures.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2347465"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of sestrin 2 as a sepsis marker and predictor of disease severity. 评估作为败血症标志物和疾病严重程度预测指标的胰岛素 2。

IF 2.7 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-11-03 DOI: 10.1080/13685538.2024.2424300

Osman Baspınar, Derya Kocer, Kaniye Aydın, Oguzhan Sıtkı Dizdar

{"title":"Assessment of sestrin 2 as a sepsis marker and predictor of disease severity.","authors":"Osman Baspınar, Derya Kocer, Kaniye Aydın, Oguzhan Sıtkı Dizdar","doi":"10.1080/13685538.2024.2424300","DOIUrl":"https://doi.org/10.1080/13685538.2024.2424300","url":null,"abstract":"Introduction: Sestrin 2 is considered a stress-inducible antioxidant protein. This study was aimed to evaluate sestrin 2 in subjects with sepsis, and its correlation with clinical severity and mortality.Methods: Sepsis and control group patients were followed from admission to discharge. A blood sample was taken at admission for determination of serum sestrin 2 level.Results: Of the total 42 patients with sepsis, there were 25 females and the mean age was 74.9 years. The sestrin 2 levels were significantly higher in the sepsis group. The optimum sestrin 2 cut-off point of ≥3.13 ng/mL had 95.2% sensitivity and 71.4% specificity for sepsis (p < .001). Sestrin 2 levels were higher in patients who needed renal replacement therapy (p = .018), patients who needed vasopressor therapy (p = .001) and patients with organ dysfunction (p = .002). The sestrin 2 level was significantly correlated with Acute Physiology and Chronic Health Evaluation (APACHE) II score, Nutrition Risk in the Critically Ill (NUTRIC) Score, C-reactive protein and albumin. Sestrin 2 levels were not associated with 30 d mortality in sepsis patients.Conclusions: Sestrin 2 was significantly higher in the sepsis patients and associated with sepsis related adverse clinical outcomes. These results provided information concerning the clinical utility of sestrin 2.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2424300"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is erectile dysfunction more prevalent from COVID-19's beginning and onwards? What do relevant Google searches show? 从新冠肺炎开始及以后，勃起功能障碍是否更普遍？相关的谷歌搜索显示了什么？

IF 2.6 4区医学

Aging Male Pub Date : 2023-12-01 Epub Date: 2023-09-25 DOI: 10.1080/13685538.2023.2256401

Ioannis Ilias, Charalampos Milionis, Evangelia Venaki, Eftychia Koukkou

引用次数: 0

Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study. 睾酮和性激素结合球蛋白影响癌症风险吗？孟德尔随机化和生物信息学研究。

IF 2.6 4区医学

Aging Male Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI: 10.1080/13685538.2023.2261524

Xiwen Liu, Lixuan Lin, Qi Cai, Caichen Li, Haoxiang Xu, Ruiqi Zeng, Mingtong Zhang, Xinyi Qiu, Shiqi Chen, Xizhe Zhang, Linchong Huang, Wenhua Liang, Jianxing He

{"title":"Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study.","authors":"Xiwen Liu, Lixuan Lin, Qi Cai, Caichen Li, Haoxiang Xu, Ruiqi Zeng, Mingtong Zhang, Xinyi Qiu, Shiqi Chen, Xizhe Zhang, Linchong Huang, Wenhua Liang, Jianxing He","doi":"10.1080/13685538.2023.2261524","DOIUrl":"10.1080/13685538.2023.2261524","url":null,"abstract":"Using Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichment analyses of single nucleotide polymorphisms (SNPs) associated with cancer allowed for a comprehensive bioinformatics approach, which offered a deeper biological understanding of these relationships. The results indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer. Conversely, increased testosterone was linked to lower stomach cancer risk for men, whereas high SHBG levels were related to decreased risks of breast and prostate cancers. The corresponding genes of the identified SNPs, as revealed by pathway enrichment analysis, were involved in significant metabolic and proliferative pathways. These findings emphasize the need for further research into the biological mechanisms behind these associations, paving the way for potential targeted interventions in preventing and treating these cancers.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2261524"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008. 美国男性血清尿酸水平与良性前列腺增生的关系：2005年至2008年NHANES结果。

IF 2.6 4区医学

Aging Male Pub Date : 2023-12-01 Epub Date: 2023-10-28 DOI: 10.1080/13685538.2023.2275775

Hang Zhou, Mingming Xu, Xuexue Hao, Zhunan Xu, Yang Pan, Xiaoqiang Liu

{"title":"Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008.","authors":"Hang Zhou, Mingming Xu, Xuexue Hao, Zhunan Xu, Yang Pan, Xiaoqiang Liu","doi":"10.1080/13685538.2023.2275775","DOIUrl":"10.1080/13685538.2023.2275775","url":null,"abstract":"Background: The relationship between uric acid (UA) and benign prostatic hyperplasia (BPH) is controversial and has rarely been studied in American populations.Methods: Data from two cycles of the National Health and Nutrition Examination Surveys, comprising data from 2005 to 2008, were used. The majority of BPH were identified by self-report. We investigated the relationship between UA and BPH using univariate and multivariate logistic regression analyses.Results: 2,845 participants were enrolled in the study, including 531 participants with BPH and 2,314 controls. After fully adjusting for all confounders, the risk of developing BPH was reduced by 18% for every 100 μmol/L increase in UA (OR = 0.82, 95% CI: 0.69-0.97, p = 0.023). Participants in the highest quartile of UA were found to have a reduced likelihood of developing BPH (ORQ4vs1 = 0.61, 95% CI: 0.41-0.91) in comparison to those in the lowest quartile of UA. Subgroup analyses found that among those younger than 60 years, non-Hispanic whites, former smokers, heavy drinkers, those without diabetes, or those with hypertension, high UA remained negatively associated with BPH.Conclusions: The above results suggest that UA may be a potential protective factor for BPH, but the mechanism needs to be further explored.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2275775"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenic obesity is not associated with sexual dysfunction in older adults: a cross-sectional study. 一项横断面研究显示，老年人的肌肉型肥胖与性功能障碍无关。

IF 2.6 4区医学

Aging Male Pub Date : 2023-12-01 Epub Date: 2023-10-31 DOI: 10.1080/13685538.2023.2252502

Filiz Demirdağ, Burcu Kıvrak Güçer, Esma Nur Kolbaşı

{"title":"Sarcopenic obesity is not associated with sexual dysfunction in older adults: a cross-sectional study.","authors":"Filiz Demirdağ, Burcu Kıvrak Güçer, Esma Nur Kolbaşı","doi":"10.1080/13685538.2023.2252502","DOIUrl":"10.1080/13685538.2023.2252502","url":null,"abstract":"Background: This study aimed to investigate the frequency of sexual dysfunction (SD) and the association between SD and body composition abnormalities, such as sarcopenia, obesity, and sarcopenic obesity.Methods: Older adults (≥65 years) were included. Sarcopenic obesity was diagnosed by using newly defined ESPEN-EASO diagram. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People criteria. Obesity was defined using the fat percentile cut-offs suggested by ESPEN-EASO. SD was determined by Arizona Sexual Experience Scale (ASEX).Results: Two-hundred and sixty-seven volunteers (64.4% female, mean age 73.63 ± 6.22 years) participated in this study. One-hundred seventy-eight individuals (66.7%) had SD. It was present in 83.1% and 36.8% of the females and males, respectively (p < 0.0001). There was no association between SD and sarcopenia alone (OR: 1.359, 95% CI: 0.650-2.838, p = 0.415) or obesity alone (OR: 0.986, 95% CI: 0.543-1.791, p = 0.963). Sarcopenic obesity was significantly associated with SD (OR: 9.116, 95% CI: 1.173-70.851, p = 0.035). However, this significance was lost after the model was adjusted for gender, marital status, and comorbidities (OR: 4.676, 95% CI: 0.578-37.801, p = 0.148).Conclusions: SD was present in 66.7% of the older adults and was not associated with sarcopenia, obesity, or sarcopenic obesity. Further longitudinal studies are needed on this topic.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2252502"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between depressive mood and subjective health in centenarians and near-centenarians: a cross-sectional study from Korean centenarian cohort. 百岁老人和近百岁老人抑郁情绪与主观健康之间的关系：一项来自韩国百岁老人队列的横断面研究。

IF 2.6 4区医学

Aging Male Pub Date : 2023-12-01 Epub Date: 2023-10-09 DOI: 10.1080/13685538.2023.2257302

Min Jhon, Min-Ho Shin, Kyung Chul Yoon, Jeong-Sun Kim, Jeonghwa Lee, Kwangsung Park, Sang Chul Park

{"title":"The relationship between depressive mood and subjective health in centenarians and near-centenarians: a cross-sectional study from Korean centenarian cohort.","authors":"Min Jhon, Min-Ho Shin, Kyung Chul Yoon, Jeong-Sun Kim, Jeonghwa Lee, Kwangsung Park, Sang Chul Park","doi":"10.1080/13685538.2023.2257302","DOIUrl":"10.1080/13685538.2023.2257302","url":null,"abstract":"Abstract Background With the rapid increase in population longevity, more clinical attention is being paid to the overall health of long-lived people, especially centenarians. Subjective health, which is the perception of one’s health status, predicts both mortality and declining physical function in older adults. The purpose of this study was to investigate the factors related to subjective health among centenarians and near-centenarians (ages ≥95) living in a rural area of South Korea. Methods A total of 101 participants were enrolled from four different regions (Gurye, Gokseong, Sunchang, and Damyang), known as the Longevity Belt in Korea. Variables assessing physical and mental health, including the results of blood tests, were examined. Factors associated with good subjective health were identified with logistic regression analysis. Results Fifty-six participants (59.6%) were subjectively healthy among the centenarians and near-centenarians. Logistic regression analysis revealed that depressive mood was the only factor associated with subjective health and was negatively correlated. The regression model explained 39% of the variance in subjective health. Conclusions These findings emphasize the importance of mental health at very advanced ages. Because depressive mood negatively correlates with subjective health, more attention is needed to prevent and manage mood symptoms of people of advanced ages, including centenarians.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2257302"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0