Aging Male最新文献

{"title":"Intermittent urethral infusion of dimethylsulfoxide for urethral amyloidosis: a case report and literature review.","authors":"Yunzhi Ii,&nbsp;Guojing Gao,&nbsp;Xiaoxing Liao,&nbsp;Jianghua Yang,&nbsp;Rongzhen Ye,&nbsp;Xiaofeng Zheng","doi":"10.1080/13685538.2022.2097220","DOIUrl":"https://doi.org/10.1080/13685538.2022.2097220","url":null,"abstract":"<p><p>Urethral amyloidosis (UA) is a very rare condition. We here report the case of a 63-year-old male patient who was admitted to our outpatient department due to aggravating dysuria, frequent urination, pain during intercourse, and a gradually enlarging mass at the ostium of his urethra, which he first notice one year earlier. Pathological tissue biopsy of urethral ostium mass confirmed UA. Intermittent urethra infusion of dimethyl sulfoxide was performed and the treatment effect is satisfactory.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40510446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of testosterone deficiency among US adult males.","authors":"Nuozhou Liu,&nbsp;Ying Feng,&nbsp;Xue Ma,&nbsp;Fang Ma","doi":"10.1080/13685538.2022.2130236","DOIUrl":"https://doi.org/10.1080/13685538.2022.2130236","url":null,"abstract":"Dear Editor, Testosterone is a fundamental sex hormone made by testicular Leydig cells and affects numerous sexual and nonsexual functions. Testosterone deficiency (TD) is characterized by low testosterone combined with one or more symptoms including decreased muscle mass, libido and energy, poor cognition, and depression [1]. Previous studies indicated that about 7% of men would be affected by TD followed by several sexual and nonsexual symptoms in their 50 s, and the prevalence rate of TD in US males was 12.3% in the 40–69-year-old US male population (estimated from the Massachusetts Male Aging Study) [1,2]. However, the exact prevalent condition of TD in US adult males of all ages is still not clear. Hence, we estimated the prevalence of TD using data from the National Health and Nutrition Examination Survey (NHANES), which represent the condition of the whole non-institutionalized US civilians. We obtained data from NHANES 2013–2014 to 2015–2016, since only these two cycles were available for complete testosterone information. NHANES is an ongoing cross-sectional and multistage probability sample survey to reflect the nutritional and health status of the US population. Participants less than 20 years old or without available testosterone data were excluded from our analysis. And a man with a total testosterone <300 ng/dL can be defined as TD, according to 2018 American Urological Association (AUA) guidelines [3]. The prevalence rate and 95% confidence interval (95% CI) were presented in the overall sample and participants which were stratified by age and body mass index (BMI) condition. The p value for linear trends was calculated from linear regression while treating the NHANES cycle or age and BMI group into continuous variables. Weighted logistic regressions were used to assess the association between age and BMI group and the likelihood of testosterone. All analyses were performed by R version 4.0.5[Q3] and SPSS version 26.0 (IBM, Armonk, NY). A total of 5000 adult males (weighted, N1⁄4 213,316,904) with an average age of 47.51 ± 19.68 (mean ± SD) were included in this study. The overall prevalence rate TD was 26.2 (95% CI, 23.9, 28.6) for NHANES 2013–2014 and 25.8 (95% CI, 22.5, 29.1) for NHANES 2015–2016 (linear p1⁄4 0.8340) (Table 1). And the prevalence rate was significantly higher in elder, overweight, or obese males in both two NHANES cycles. Figure 1 presented the results of multivariable logistic regressions with combined cycles. In general, elder people had a higher risk of TD, especially people aged over 70 years old (OR for age 70–791⁄4 1.95, 95% CI, 1.34, 2.83; OR for age �801⁄4 4.04, 95% CI, 2.80, 5.80). Both","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on androgen replacement therapy and lower urinary tract symptoms: a narrative review.","authors":"Raed M Al-Zoubi,&nbsp;Mustafa Alwani,&nbsp;Omar M Aboumarzouk,&nbsp;Mai Elaarag,&nbsp;Ahmad R Al-Qudimat,&nbsp;Laxmi Ojha,&nbsp;Aksam Yassin","doi":"10.1080/13685538.2022.2118253","DOIUrl":"https://doi.org/10.1080/13685538.2022.2118253","url":null,"abstract":"Abstract Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as hesitancy, intermittency, weak stream, nocturia, urine frequency, and urgency. Additionally, LUTS (obstructive or irritative symptoms) are common in elderly men with hypogonadism, identified as the reduced testes capability in producing sex steroids and sperm, and are categorized as testosterone deficiency. Even though the mode of action (MoA) of testosterone therapy (TTh) on hypogonadal men needs more researched and understanding, the effectiveness of TTh in the development of male genital organs has been reported in several studies. This review shows the latest updates of TTh in LUTS including potential adverse effects, advantages, and disadvantages. Graphical Abstract","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40353669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of testosterone therapy on bone turnover markers in obese males with type 2 diabetes and functional hypogonadism.","authors":"Kristina Groti Antonič","doi":"10.1080/13685538.2022.2134338","DOIUrl":"https://doi.org/10.1080/13685538.2022.2134338","url":null,"abstract":"<p><strong>Methods: </strong>Fifty-five obese males with type 2 diabetes mellitus and functional hypogonadism participated in a 2-year, double-blind, placebo-controlled study of testosterone undecanoate (TU). Bone turnover markers C-telopeptide of type I collagen (CTX) and procollagen I N-terminal propeptide (PINP) were assessed at baseline, 12 and 24 months. Bone mineral density (BMD) changes were evaluated after 24 months using dual-energy X-ray absorptiometry. Group T (<i>n</i> = 28) received TU both years. Group P (<i>n</i> = 27) received placebo first year and TU second year.</p><p><strong>Results: </strong>CTX decreased in group P from 1055 (676-1344) to 453 (365-665) pmol/L (<i>p</i> < 0.001) and from 897 (679-1506) to 523 (364-835) pmol/L (<i>p</i> < 0.001) in T. PINP decreased by 4.30 ± 8.05 μg/L in group P (<i>p</i> = 0.030) and 4.64 ± 8.86 μg/L in T (<i>p</i> < 0.023) after first year of therapy. No femoral neck BMD changes were observed in 32 patients from both groups (<i>n</i> = 16 per group). Lumbar spine BMD increased (by 0.075 ± 0.114 g/cm²; <i>p</i> = 0.019) in group T following two years of treatment.</p><p><strong>Conclusions: </strong>We observed decreased CTX, decreased PINP and increased lumbar spine BMD after two years of testosterone treatment.</p><p><strong>Clinical trials: </strong>NCT03792321; retrospectively registered trial on 4 January 2019.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10779054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study.","authors":"Aksam Yassin,&nbsp;Farid Saad,&nbsp;Mustafa Alwani,&nbsp;Omar M Aboumarzouk,&nbsp;Raed M Al-Zoubi,&nbsp;Joanne Nettleship,&nbsp;Daniel Kelly,&nbsp;Abdulla Al-Ansari","doi":"10.1080/13685538.2022.2099828","DOIUrl":"https://doi.org/10.1080/13685538.2022.2099828","url":null,"abstract":"<p><p>Testosterone therapy (TTh) is the primary treatment for aging men with functional hypogonadism. Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect of TTh on endocrine parameters in hypogonadal men at a 12-year follow-up. In this single-centre, cumulative, prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testosterone undecanoate injections in 12-week intervals for up to 12 years. Blood samples were taken at every other visit to measure levels of total T (TT), calculated free T, sex hormone-binding globulin (SHBG), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and prolactin. We observed an increase in TT of 15.5 nmol/L (<i>p</i> < 0.0001), a reduction in SHBG of 10.5 nmol/L (<i>p</i> < 0.0001) and an increase in calculated free T of 383.04 pmol/L (<i>p</i> < 0.0001) over the study period. This was accompanied by an increase in estradiol levels by 14.9 pmol/L (<i>p</i> < 0.0001), and decreases in progesterone (0.2 ng/mL, <i>p</i> < 0.0001), LH (10.4 U/L, <i>p</i> < 0.0001) and FSH (8.4 U/L, <i>p</i> < 0.0001) were demonstrated at 12-years. The levels of prolactin remained unchanged. Long-term TTh altered hormonal parameters to predictably modify the endocrine system. These effects were sustained during the entire observation time of 12 years.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40644900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of seminal low-risk human papillomavirus infection on sperm parameters of adult men.","authors":"Rossella Cannarella,&nbsp;Antonio Aversa,&nbsp;Rosita A Condorelli,&nbsp;Silvia De Cristofaro,&nbsp;Emanuela Greco,&nbsp;Agata Grillo,&nbsp;Aldo E Calogero,&nbsp;Sandro La Vignera","doi":"10.1080/13685538.2021.2023126","DOIUrl":"https://doi.org/10.1080/13685538.2021.2023126","url":null,"abstract":"<p><p><b>Aim:</b> We aimed to evaluate the impact of seminal low-risk human Papillomavirus (LR-HPV) infection on sperm conventional parameters.<b>Material and methods:</b> This was a retrospective case-control study including patients attending to our center for infertility. Patients with evidence for high risk (HR)-HPV infection previously or at the time of enrollment, and/or with severe oligozoospermia (sperm concentration <5 mil/ml) were ruled out. Twenty selected patients positive for a LR-HPV and 20 control subjects with no evidence of HPV DNA and with available results of sperm analysis were consecutively enrolled.<b>Results:</b> Patients positive for LR-HPV had a mean age of 31.0 + 11.0 years, while controls were 35.0 + 8.0-year-old (p > .05). Sperm concentration, total sperm count, sperm progressive motility, morphology, and leukocyte concentration did not differ between patients and controls. However, the prevalence of oligozoospermia was significantly higher in patients than controls (50% vs. 15%). No difference in the prevalence of astenozoospermia (30% vs. 40%) or teratozoospermia (15% vs. 15%) was found.<b>Conclusion:</b> We found no difference in sperm conventional parameters in LR-HPV infected patients than in controls. These data might prompt to research the impact on LR-HPV genotype on male fertility. Particularly, evidence on sperm DNA fragmentation (SDF) and pregnancy outcome is needed.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39783063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the type of biopsy used for diagnosis impact subsequent treatment selection in prostate cancer patients?","authors":"Brandon A Levin,&nbsp;Daniel J Lama,&nbsp;Jonathan Sussman,&nbsp;Tianyuan Guan,&nbsp;Marepalli Rao,&nbsp;Juliana Tobler,&nbsp;Sadhna Verma,&nbsp;Abhinav Sidana","doi":"10.1080/13685538.2021.2023125","DOIUrl":"https://doi.org/10.1080/13685538.2021.2023125","url":null,"abstract":"<p><strong>Purpose: </strong>Multiparametric magnetic resonance imaging (mpMRI) targeted biopsy has emerged as an augmentation to systematic prostate biopsy (SBx) with improved diagnostic accuracy. The purpose of this study was to determine whether biopsy modality impacted management of prostate cancer (PCa).</p><p><strong>Methods: </strong>We performed a retrospective review of patients with newly diagnosed non-metastatic PCa at our institution (2014-2020). Either ultrasound-guided 12-core SBx or SBx plus ≥1targeted biopsy cores from identifiable lesions on mpMRI were performed. Patients were managed with active surveillance (AS), radiation therapy (RT), or radical prostatectomy (RP). Multivariate logistic and multinomial regression analyses were performed.</p><p><strong>Results: </strong>Of 578 patients, 221(38%) proceeded with AS, 121(21%) received RT, and 236(41%) underwent RP. Median age and prostate-specific antigen (PSA) were 65.4 years and 7.2 ng/mL, respectively. On multivariate analysis, biopsy type did not predict decision to pursue treatment (<i>p</i>=.951). On multinomial regression analysis, biopsy type did not predict selection of AS over RP (<i>p</i>=.973) or RT over RP (<i>p</i>=.813). Alternatively, age, grade group, and PSA were significant predictors of management selection.</p><p><strong>Conclusions: </strong>Biopsy technique did not impact management for patients with new PCa diagnosis. Despite paradigm shifts in obtaining tissue diagnosis, age, PSA, and grade group remain valuable indices for shared decision-making and counseling patients with PCa.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39784651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of testosterone change as men age.","authors":"Ricky Kanabar,&nbsp;Allan Mazur,&nbsp;Alexander Plum,&nbsp;Julian Schmied","doi":"10.1080/13685538.2021.2023493","DOIUrl":"https://doi.org/10.1080/13685538.2021.2023493","url":null,"abstract":"<p><p><b>Objective:</b> The literature on testosterone (T) in men reports diverse correlates of T, some with minimal empirical support and most with little indication of how they change with advancing age. We test eight putative correlations across age.<b>Method:</b> Correlations were tested on a large sample of British men.<b>Results:</b> Seven of eight correlations replicated. Most change across men's life courses. The diurnal cycle of T is considerably weaker among older than younger men. Single men have higher T than married men of the same age; however, this difference lessens as men get older. Elevated T among smokers is less pronounced as men age. The inverse relationship between obesity and T is sustained across the adult age range. The lessening of T with age is well established, however there is disagreement about the course of decline. We find T having a steep decline around age 30, with possibly a rebound around age 50, after which levels remain roughly constant. Correlations involving health become stronger among older men. After age 30 or 40, the inverse relationships between T and HbA1c, diabetes, and metabolic syndrome all become increasingly significant, though not necessarily strong in magnitude.<b>Conclusion:</b> Most putative correlates of T are replicated. There is a basis here for the generalization that among older men, those healthy have higher T than those who are not, but not a lot higher.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10868133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of dual-energy CT angiography in diagnosis of arterial erectile dysfunction: new scanning technology, new scanning area.","authors":"Ming Wang,&nbsp;Yutian Dai,&nbsp;Hui Jiang,&nbsp;Andrea Sansone,&nbsp;Emmanuele A Jannini,&nbsp;Xiansheng Zhang","doi":"10.1080/13685538.2022.2121815","DOIUrl":"https://doi.org/10.1080/13685538.2022.2121815","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the value of dual-energy computed tomography (DE-CT) angiography in diagnosis of arteriogenic erectile dysfunction (ED) patients and feasibility of new scanning area that excludes the testis.</p><p><strong>Materials and methods: </strong>Ninety-three patients suspected of suffering arterial ED and 40 health volunteers underwent penile duplex Doppler ultrasound and DE-CT angiography (DE-CTA). The scanning range of DE-CTA covered whole arterial system of pelvis and testis was excluded. Two blinded investigators independently evaluated the arterial system that supplies the penis.</p><p><strong>Results: </strong>Finally, 1596 segments were evaluated and 470 segments were judged to be abnormal. The distribution was: 2 (0.4%) in common iliac artery, 7 (1.5%) in internal iliac artery, 82 (17.5%) in internal pudendal artery, 89 (18.9%) in penile artery, 120 (25.5%) in dorsal artery, and 170 (36.2%) in cavernosal artery. The specificity, sensitivity, positive predictive value, and negative predictive value of DE-CTA in diagnostic were 86.02%, 87.50%, 94.12%, and 72.92%. Besides, the new scan area allowed for effective evaluation of the arteries while excluding the testis.</p><p><strong>Conclusion: </strong>DE-CTA can provide unbiased, safe evaluation of the vascular status of the penile bed in patients with ED.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40356085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between erectile function and adiponectin levels in men with late-onset hypogonadism.","authors":"Kazuyoshi Shigehara,&nbsp;Yuki Kato,&nbsp;Hiroyuki Konaka,&nbsp;Shohei Kawaguchi,&nbsp;Takahiro Nohara,&nbsp;Kouji Izumi,&nbsp;Yoshifumi Kadono,&nbsp;Mikio Namiki,&nbsp;Atsushi Mizokami","doi":"10.1080/13685538.2022.2119955","DOIUrl":"https://doi.org/10.1080/13685538.2022.2119955","url":null,"abstract":"<p><p><b>Aim:</b> This study investigated the relationship between erectile dysfunction (ED) and adiponectin levels in hypogonadal men.<b>Methods:</b> In this study, 218 patients with hypogonadism (mean age: 65.1 ± 8.3 years) were enrolled. All patients underwent physical examinations, with measurement of body mass index, body fat ratio, and waist circumference. The erectile function was assessed using the sexual health inventory for men (SHIM) scoring system. Blood biochemical profiles such as free testosterone, fasting blood glucose, and lipid profile including adiponectin levels were measured. All patients were divided into two groups based on their SHIM score: normal to moderate ED (SHIM score ≥ 12) and severe ED (SHIM score < 12), and the factors associated with severe ED were determined. Patients with severe ED were divided into two groups based on adiponectin levels (cutoff value of 7.0 μg/mL), and their basic characteristics were compared between these two groups.<b>Results:</b> The severe ED group was older and had higher adiponectin levels. In patients with severe ED, various metabolic parameters were significantly worse in the low adiponectin groups than in the non-low adiponectin group.<b>Conclusions:</b> The risk of developing cardiovascular diseases is extremely high in hypogonadal men with severe ED who had lower serum adiponectin levels.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40393922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}