Aging Male最新文献

{"title":"Assessment of sestrin 2 as a sepsis marker and predictor of disease severity.","authors":"Osman Baspınar, Derya Kocer, Kaniye Aydın, Oguzhan Sıtkı Dizdar","doi":"10.1080/13685538.2024.2424300","DOIUrl":"https://doi.org/10.1080/13685538.2024.2424300","url":null,"abstract":"<p><strong>Introduction: </strong>Sestrin 2 is considered a stress-inducible antioxidant protein. This study was aimed to evaluate sestrin 2 in subjects with sepsis, and its correlation with clinical severity and mortality.</p><p><strong>Methods: </strong>Sepsis and control group patients were followed from admission to discharge. A blood sample was taken at admission for determination of serum sestrin 2 level.</p><p><strong>Results: </strong>Of the total 42 patients with sepsis, there were 25 females and the mean age was 74.9 years. The sestrin 2 levels were significantly higher in the sepsis group. The optimum sestrin 2 cut-off point of ≥3.13 ng/mL had 95.2% sensitivity and 71.4% specificity for sepsis (<i>p</i> < .001). Sestrin 2 levels were higher in patients who needed renal replacement therapy (<i>p</i> = .018), patients who needed vasopressor therapy (<i>p</i> = .001) and patients with organ dysfunction (<i>p</i> = .002). The sestrin 2 level was significantly correlated with Acute Physiology and Chronic Health Evaluation (APACHE) II score, Nutrition Risk in the Critically Ill (NUTRIC) Score, C-reactive protein and albumin. Sestrin 2 levels were not associated with 30 d mortality in sepsis patients.</p><p><strong>Conclusions: </strong>Sestrin 2 was significantly higher in the sepsis patients and associated with sepsis related adverse clinical outcomes. These results provided information concerning the clinical utility of sestrin 2.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2424300"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is erectile dysfunction more prevalent from COVID-19's beginning and onwards? What do relevant Google searches show?","authors":"Ioannis Ilias,&nbsp;Charalampos Milionis,&nbsp;Evangelia Venaki,&nbsp;Eftychia Koukkou","doi":"10.1080/13685538.2023.2256401","DOIUrl":"10.1080/13685538.2023.2256401","url":null,"abstract":"","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2256401"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study.","authors":"Xiwen Liu, Lixuan Lin, Qi Cai, Caichen Li, Haoxiang Xu, Ruiqi Zeng, Mingtong Zhang, Xinyi Qiu, Shiqi Chen, Xizhe Zhang, Linchong Huang, Wenhua Liang, Jianxing He","doi":"10.1080/13685538.2023.2261524","DOIUrl":"10.1080/13685538.2023.2261524","url":null,"abstract":"<p><p>Using Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichment analyses of single nucleotide polymorphisms (SNPs) associated with cancer allowed for a comprehensive bioinformatics approach, which offered a deeper biological understanding of these relationships. The results indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer. Conversely, increased testosterone was linked to lower stomach cancer risk for men, whereas high SHBG levels were related to decreased risks of breast and prostate cancers. The corresponding genes of the identified SNPs, as revealed by pathway enrichment analysis, were involved in significant metabolic and proliferative pathways. These findings emphasize the need for further research into the biological mechanisms behind these associations, paving the way for potential targeted interventions in preventing and treating these cancers.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2261524"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008.","authors":"Hang Zhou,&nbsp;Mingming Xu,&nbsp;Xuexue Hao,&nbsp;Zhunan Xu,&nbsp;Yang Pan,&nbsp;Xiaoqiang Liu","doi":"10.1080/13685538.2023.2275775","DOIUrl":"10.1080/13685538.2023.2275775","url":null,"abstract":"<p><strong>Background: </strong>The relationship between uric acid (UA) and benign prostatic hyperplasia (BPH) is controversial and has rarely been studied in American populations.</p><p><strong>Methods: </strong>Data from two cycles of the National Health and Nutrition Examination Surveys, comprising data from 2005 to 2008, were used. The majority of BPH were identified by self-report. We investigated the relationship between UA and BPH using univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>2,845 participants were enrolled in the study, including 531 participants with BPH and 2,314 controls. After fully adjusting for all confounders, the risk of developing BPH was reduced by 18% for every 100 μmol/L increase in UA (OR = 0.82, 95% CI: 0.69-0.97, <i>p</i> = 0.023). Participants in the highest quartile of UA were found to have a reduced likelihood of developing BPH (OR_Q4vs1 = 0.61, 95% CI: 0.41-0.91) in comparison to those in the lowest quartile of UA. Subgroup analyses found that among those younger than 60 years, non-Hispanic whites, former smokers, heavy drinkers, those without diabetes, or those with hypertension, high UA remained negatively associated with BPH.</p><p><strong>Conclusions: </strong>The above results suggest that UA may be a potential protective factor for BPH, but the mechanism needs to be further explored.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2275775"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenic obesity is not associated with sexual dysfunction in older adults: a cross-sectional study.","authors":"Filiz Demirdağ,&nbsp;Burcu Kıvrak Güçer,&nbsp;Esma Nur Kolbaşı","doi":"10.1080/13685538.2023.2252502","DOIUrl":"10.1080/13685538.2023.2252502","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the frequency of sexual dysfunction (SD) and the association between SD and body composition abnormalities, such as sarcopenia, obesity, and sarcopenic obesity.</p><p><strong>Methods: </strong>Older adults (≥65 years) were included. Sarcopenic obesity was diagnosed by using newly defined ESPEN-EASO diagram. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People criteria. Obesity was defined using the fat percentile cut-offs suggested by ESPEN-EASO. SD was determined by Arizona Sexual Experience Scale (ASEX).</p><p><strong>Results: </strong>Two-hundred and sixty-seven volunteers (64.4% female, mean age 73.63 ± 6.22 years) participated in this study. One-hundred seventy-eight individuals (66.7%) had SD. It was present in 83.1% and 36.8% of the females and males, respectively (<i>p</i> < 0.0001). There was no association between SD and sarcopenia alone (OR: 1.359, 95% CI: 0.650-2.838, <i>p</i> = 0.415) or obesity alone (OR: 0.986, 95% CI: 0.543-1.791, <i>p</i> = 0.963). Sarcopenic obesity was significantly associated with SD (OR: 9.116, 95% CI: 1.173-70.851, <i>p</i> = 0.035). However, this significance was lost after the model was adjusted for gender, marital status, and comorbidities (OR: 4.676, 95% CI: 0.578-37.801, <i>p</i> = 0.148).</p><p><strong>Conclusions: </strong>SD was present in 66.7% of the older adults and was not associated with sarcopenia, obesity, or sarcopenic obesity. Further longitudinal studies are needed on this topic.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2252502"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between depressive mood and subjective health in centenarians and near-centenarians: a cross-sectional study from Korean centenarian cohort.","authors":"Min Jhon,&nbsp;Min-Ho Shin,&nbsp;Kyung Chul Yoon,&nbsp;Jeong-Sun Kim,&nbsp;Jeonghwa Lee,&nbsp;Kwangsung Park,&nbsp;Sang Chul Park","doi":"10.1080/13685538.2023.2257302","DOIUrl":"10.1080/13685538.2023.2257302","url":null,"abstract":"Abstract Background With the rapid increase in population longevity, more clinical attention is being paid to the overall health of long-lived people, especially centenarians. Subjective health, which is the perception of one’s health status, predicts both mortality and declining physical function in older adults. The purpose of this study was to investigate the factors related to subjective health among centenarians and near-centenarians (ages ≥95) living in a rural area of South Korea. Methods A total of 101 participants were enrolled from four different regions (Gurye, Gokseong, Sunchang, and Damyang), known as the Longevity Belt in Korea. Variables assessing physical and mental health, including the results of blood tests, were examined. Factors associated with good subjective health were identified with logistic regression analysis. Results Fifty-six participants (59.6%) were subjectively healthy among the centenarians and near-centenarians. Logistic regression analysis revealed that depressive mood was the only factor associated with subjective health and was negatively correlated. The regression model explained 39% of the variance in subjective health. Conclusions These findings emphasize the importance of mental health at very advanced ages. Because depressive mood negatively correlates with subjective health, more attention is needed to prevent and manage mood symptoms of people of advanced ages, including centenarians.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"26 1","pages":"2257302"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced sleep duration increases the risk of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in middle-aged and elderly males: a national cross-sectional study.","authors":"Yang Xiong,&nbsp;Yangchang Zhang,&nbsp;Fuxun Zhang,&nbsp;Changjing Wu,&nbsp;Feng Qin,&nbsp;Jiuhong Yuan","doi":"10.1080/13685538.2022.2079627","DOIUrl":"https://doi.org/10.1080/13685538.2022.2079627","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) remains high in men. However, whether reduced sleep duration enhances the risk of LUTS/BPH remains unknown.</p><p><strong>Materials and methods: </strong>The 2015 China Health and Retirement Longitudinal Study was used in this study. Binary logistic regression was adopted to test the relationship between sleep duration and LUTS/BPH. Restricted cubic spline (RCS) regression was used to examine the non-linear association. In sensitivity analyses, propensity scores matching was performed to verify the robustness of the results.</p><p><strong>Results: </strong>In this study, 8,920 males aged 40 years above were enrolled. In the fully adjusted logistic model, across the quartiles of sleep duration, the odds ratios of LUTS/BPH were 1.00 (reference), 0.94 (95% CI 0.77-1.15), 0.74 (95% CI 0.58-0.94), 0.54 (0.37-0.75), respectively. The results of RCS indicated a non-linear inverted U-shaped association between sleep duration and LUTS/BPH (<i>p</i> for non-linearity <0.05). In the subgroup analyses, no significant effects of settlements, alcohol and cigarette consumption, depression, and hypertension on the association between sleep duration and prevalent LUTS/BPH were observed (<i>p</i> for interaction >0.05).</p><p><strong>Conclusion: </strong>Reduced sleep duration is significantly associated with the increases of the LUTS/BPH risk in Chinese middle-aged and elderly males.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"159-166"},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of testosterone therapy on bone turnover markers in obese males with type 2 diabetes and functional hypogonadism.","authors":"Kristina Groti Antonič","doi":"10.1080/13685538.2022.2134338","DOIUrl":"https://doi.org/10.1080/13685538.2022.2134338","url":null,"abstract":"<p><strong>Methods: </strong>Fifty-five obese males with type 2 diabetes mellitus and functional hypogonadism participated in a 2-year, double-blind, placebo-controlled study of testosterone undecanoate (TU). Bone turnover markers C-telopeptide of type I collagen (CTX) and procollagen I N-terminal propeptide (PINP) were assessed at baseline, 12 and 24 months. Bone mineral density (BMD) changes were evaluated after 24 months using dual-energy X-ray absorptiometry. Group T (<i>n</i> = 28) received TU both years. Group P (<i>n</i> = 27) received placebo first year and TU second year.</p><p><strong>Results: </strong>CTX decreased in group P from 1055 (676-1344) to 453 (365-665) pmol/L (<i>p</i> < 0.001) and from 897 (679-1506) to 523 (364-835) pmol/L (<i>p</i> < 0.001) in T. PINP decreased by 4.30 ± 8.05 μg/L in group P (<i>p</i> = 0.030) and 4.64 ± 8.86 μg/L in T (<i>p</i> < 0.023) after first year of therapy. No femoral neck BMD changes were observed in 32 patients from both groups (<i>n</i> = 16 per group). Lumbar spine BMD increased (by 0.075 ± 0.114 g/cm²; <i>p</i> = 0.019) in group T following two years of treatment.</p><p><strong>Conclusions: </strong>We observed decreased CTX, decreased PINP and increased lumbar spine BMD after two years of testosterone treatment.</p><p><strong>Clinical trials: </strong>NCT03792321; retrospectively registered trial on 4 January 2019.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"269-277"},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10779054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of testosterone change as men age.","authors":"Ricky Kanabar,&nbsp;Allan Mazur,&nbsp;Alexander Plum,&nbsp;Julian Schmied","doi":"10.1080/13685538.2021.2023493","DOIUrl":"https://doi.org/10.1080/13685538.2021.2023493","url":null,"abstract":"<p><p><b>Objective:</b> The literature on testosterone (T) in men reports diverse correlates of T, some with minimal empirical support and most with little indication of how they change with advancing age. We test eight putative correlations across age.<b>Method:</b> Correlations were tested on a large sample of British men.<b>Results:</b> Seven of eight correlations replicated. Most change across men's life courses. The diurnal cycle of T is considerably weaker among older than younger men. Single men have higher T than married men of the same age; however, this difference lessens as men get older. Elevated T among smokers is less pronounced as men age. The inverse relationship between obesity and T is sustained across the adult age range. The lessening of T with age is well established, however there is disagreement about the course of decline. We find T having a steep decline around age 30, with possibly a rebound around age 50, after which levels remain roughly constant. Correlations involving health become stronger among older men. After age 30 or 40, the inverse relationships between T and HbA1c, diabetes, and metabolic syndrome all become increasingly significant, though not necessarily strong in magnitude.<b>Conclusion:</b> Most putative correlates of T are replicated. There is a basis here for the generalization that among older men, those healthy have higher T than those who are not, but not a lot higher.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"29-40"},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10868133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brucellosis in older person: a case report from Qatar.","authors":"Hanadi Khamis Al Hamad,&nbsp;Navas Nadukkandiyil,&nbsp;Mohammed Al Husami,&nbsp;Hebatullah Ahmed Abdelgawad,&nbsp;Sanjeevikumar Meenakshisundaram,&nbsp;Osman Bashir Nemeri","doi":"10.1080/13685538.2022.2138851","DOIUrl":"https://doi.org/10.1080/13685538.2022.2138851","url":null,"abstract":"<p><strong>Background: </strong>Brucellosis is a multisystem disease with a broad spectrum of non-specific symptoms that generally occur within three weeks but sometimes up to 3 months after inoculation. Human brucellosis is quite uncommon in Elderly in Qatar.</p><p><strong>Case report: </strong>This report describes a case of Brucellosis in acute geriatric unit under Rumailah Hospital in Qatar. The patient was an 81-year-old Qatari Gentle man, functionally able to walk with minimal assistance and had mild cognitive impairment who presented with high-grade fever with chills, anorexia, low back pain and arthralgia for 10 days. The above complaints occurred often for 1 month and had fever intermittently. Lab investigations revealed as high CRP 117 mg/l, low Hb 9.1 g/dl and mild elevation in ALP (151 µ/l) with normal leukocyte and platelet count. His blood culture positive for <i>Brucella melitensis</i> with high brucella Antibody titter 1:1280. The diagnosis made as Brucellosis.</p><p><strong>Discussion: </strong>The clinical manifestations of Brucellosis are fever, night sweating, chills, arthralgia and loss of appetite. It seems pyrexia of unknown origin without other symptoms is most common presentation of Brucellosis in old age. The confirmation of Brucellosis made with serological tests, with significantly high titer, in the presence or absence of blood culture. Brucella antibody titers (≥1:160) are suggestive of active infection. Anemia and raised CRP and liver enzymes were the most prominent laboratory abnormalities in our patients. Previous study from Qatar reported that 41.7% had a history of raw milk consumption and 12.5% had a history of animal contact. The objectives of Brucellosis treatment include the prevention of complications and relapse.</p><p><strong>Conclusion: </strong>Our case presented with classical symptoms and received appropriate treatment on time. However, atypical clinical presentation and lack of specific history taking can delay diagnosis and treatment; it leads to serious clinical disease progression with increased complications. From this case study, we would contribute to optimal assessment and to keep differential diagnosis for unknown cause of fever can be Brucellosis in geriatric population.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"266-268"},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9150202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}