Aging Male最新文献

{"title":"Vitamin D levels in relation to sexual steroids, sexual function, and quality of life in patients of an andrology outpatient clinic.","authors":"Karim Sultan Haider, Michael Zitzmann","doi":"10.1080/13685538.2026.2630447","DOIUrl":"10.1080/13685538.2026.2630447","url":null,"abstract":"<p><strong>Objective: </strong>This study sought to delineate a putative synergistic interplay between vitamin D and testosterone and their conjoint associations with sexual function and quality of life in men presenting with symptoms of hypogonadism.</p><p><strong>Methods: </strong>A retrospective cohort analysis was performed in men attending the andrological clinic of the University Hospital Münster (Germany) between 2016 and 2021. Individuals exhibited complete biochemical, clinical, and questionnaire datasets. Endocrine parameters, validated psychometric instruments, and demographic variables were systematically evaluated.</p><p><strong>Results: </strong>Among 5,324 screened men, 2,059 fulfilled inclusion criteria (mean age 43.9 years). The cohort displayed a pronounced symptom burden (mitigated wellbeing and erectile function). 25-hydroxyvitamin D and testosterone concentrations resided predominantly within suboptimal ranges. Both vitamin D and testosterone correlated inversely with BMI and AMS scores, and positively with IIEF-EF scores (all <i>p</i> < 0.001). Effect size analyses and multiples regressions indicated a robust dependency of symptom severity on vitamin D as well as testosterone status across somatic, sexual, and metabolic indices, underscoring an interdependent relationship between vitamin D and testosterone in shaping sexual function and well-being.</p><p><strong>Conclusion: </strong>Albeit causality cannot be inferred, this analysis highlights a clinical convergence of vitamin D and testosterone in modulating sexual health and quality of life in men.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2630447"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146196148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in self-perceived physical and mental health problems causing functional limitations in US men aged 60 years or older.","authors":"Maximilian Andreas Storz, Alvaro Luis Ronco, Roman Huber","doi":"10.1080/13685538.2026.2630537","DOIUrl":"10.1080/13685538.2026.2630537","url":null,"abstract":"<p><strong>Background: </strong>Understanding aging men's perspective on functional ability is of utmost importance to tailor the delivery of medical care and to inform policy makers about aging men's primary health concerns.</p><p><strong>Methods: </strong>The purpose of this analysis was to describe trends in self-perceived physical and mental health problems causing functional limitations in US men aged ≥60 years based on National Health and Nutrition Examination Surveys data from 2011 to 2018.</p><p><strong>Results: </strong>Data from 2,494 males with a mean age of 68.56 years was analyzed. Participants reported a median number of 1 health problem causing functional limitations. With 20.54% and 17.75%, respectively, arthritis/rheumatism and back/neck problems emerged as the main problems. The predicted prevalence of arthritis/rheumatism causing functional limitations increased significantly from 2011-2012 to 2017-2018 by 9% (<i>p</i> = 0.028). Back/neck problems increased by 10% from 2011-2012 to 2015-2016 (<i>p</i> = 0.004). The predicted number of health problems causing functional difficulties was 1.81 times higher in those aged ≥80 years when compared to those aged 60 years (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Health conditions which attract higher attention from a public health point of view (e.g. cardiovascular disease or metabolic disorders) are less frequently reported among aging men when it comes to functional disabilities and physical functioning.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2630537"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of tadalafil plus mirabegron combination therapy in men with lower urinary tract symptoms and overactive bladder symptoms: a retrospective cohort study.","authors":"Abdurrahman İnkaya, Hasan Samet Güngör","doi":"10.1080/13685538.2026.2650579","DOIUrl":"10.1080/13685538.2026.2650579","url":null,"abstract":"<p><strong>Background: </strong>Men with mixed lower urinary tract symptoms (LUTS) often have storage symptoms that drive bother and quality-of-life impairment. Evidence on tadalafil plus mirabegron in routine clinical practice is limited.</p><p><strong>Objective: </strong>To determine whether tadalafil plus mirabegron was associated with clinically meaningful within-person improvement in IPSS and OABSS in men with mixed LUTS and overactive bladder (OAB) symptoms.</p><p><strong>Methods: </strong>A single-centre retrospective cohort study of 50 men treated with tadalafil 5 mg plus mirabegron 50 mg. The primary endpoints were within-person change in International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS). Secondary endpoints included bladder diary variables, maximum urinary flow rate (Qmax), post-void residual (PVR) volume, International Index of Erectile Function-5 (IIEF-5), and NIH-Chronic Prostatitis Symptom Index (NIH-CPSI).</p><p><strong>Results: </strong>Symptoms improved after combination therapy, but the OABSS response was less consistent than the IPSS response. Mean IPSS decreased by 4.18 points (95% CI -4.86 to -3.54; r_rb = -1.00; two-sided <i>P</i> < 0.001) and mean OABSS decreased by 1.86 points (95% CI -2.22 to -1.50; r_rb = -1.00; two-sided <i>P</i> < 0.001). Clinically meaningful IPSS improvement occurred in 38 of 50 men, or 76.0% (95% CI 62.6% to 85.7%); clinically meaningful OABSS improvement occurred in 17 of 50, or 34.0% (95% CI 22.4% to 47.8%). Dual response was seen in 15 of 50 men, or 30.0% (95% CI 19.1% to 43.8%). IIEF-5 increased by 2.92 points (95% CI 2.14 to 3.70; r_rb = 0.86; two-sided <i>P</i> < 0.001). Adverse events were recorded in 3 of 50 men, or 6.0% (95% CI 2.1% to 16.2%), and no patient developed acute urinary retention.</p><p><strong>Conclusions: </strong>In men with mixed LUTS and prominent storage symptoms, tadalafil plus mirabegron was associated with improvement in overall symptom burden, bladder diary measures, and erectile-function scores without an obvious retention signal. The clinical benefit was clearer for IPSS than for OABSS, so early reassessment is important to identify men who do not improve.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2650579"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between the cumulative metabolic score for visceral fat and its dynamic trajectories with the onset of cardiovascular disease in middle-aged and older adults: findings from two prospective cohorts.","authors":"Lisi Xu, Miao Sun","doi":"10.1080/13685538.2026.2650602","DOIUrl":"10.1080/13685538.2026.2650602","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) remains a leading cause of global mortality. The metabolic score for visceral fat (Mets-VF) integrates metabolic dysfunction and visceral adiposity, yet the effects of its long-term cumulative exposure (cuMets-VF) and dynamic trajectories on CVD risk remain underexplored.</p><p><strong>Methods: </strong>This prospective cohort study included participants from the China Health and Retirement Longitudinal Study (CHARLS; <i>N</i> = 4,281) and the English Longitudinal Study of Ageing (ELSA; <i>N</i> = 1,071). Mets-VF trajectories were identified using K-means clustering. Incident CVD was ascertained during follow-up. Cox proportional hazards models were applied to evaluate associations.</p><p><strong>Results: </strong>Over a median follow-up of approximately 5.0 years in CHARLS and 9.0 years in the ELSA, higher cuMets-VF levels and adverse trajectories were significantly associated with an increased CVD risk. Each unit increase in cuMets-VF was associated with a 14% higher risk of CVD in CHARLS (HR = 1.14, 95% CI: 1.07-1.22) and a 13% higher risk in ELSA (HR = 1.13, 95% CI: 1.01-1.26). Participants in the high-risk stable trajectory showed the highest cumulative CVD incidence (21.7% in CHARLS and 21.5% in ELSA).</p><p><strong>Conclusion: </strong>Long-term cumulative exposure to elevated Mets-VF and persistently adverse trajectories are robust predictors of incident CVD in middle-aged and older adults.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2650602"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible cross‑talk between sarcopenia and obstructive sleep apnea revealed by WGCNA analysis and machine learning.","authors":"Kunze Lu, Haiyan Lei, Caixing Wu, Danxia Lin, Yi Li, Yan Deng","doi":"10.1080/13685538.2026.2640269","DOIUrl":"10.1080/13685538.2026.2640269","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence suggests a potential link between obstructive sleep apnea (OSA) and sarcopenia. OSA-induced hypoxia and sleep disturbances may promote the loss of muscle mass, thereby increasing the risk of sarcopenia. This study employed bioinformatics approaches to identify key diagnostic candidate genes underlying the interaction between OSA and sarcopenia.</p><p><strong>Methods: </strong>In this study, gene expression datasets for OSA and sarcopenia were retrieved from the GEO. WGCNA was employed to identify shared common genes. Subsequently, two machine learning algorithms, SVM-RFE and RF, were utilized to determine candidate hub genes for diagnosing OSA combined with sarcopenia. The diagnostic performance of candidate hub genes was evaluated in both the discovery and validation datasets using a nomogram and ROC curve analysis.</p><p><strong>Results: </strong>Our analysis identified 20 shared common genes associated with the comorbidity of sarcopenia and OSA. From this gene set, LGR6 and ARRDC2 were identified as candidate hub genes. The developed diagnostic model demonstrated robust predictive performance in both the discovery and validation datasets.</p><p><strong>Conclusion: </strong>Our findings identify LGR6 and ARRDC2 as potential biomarkers for diagnosing comorbid OSA and sarcopenia. Moreover, a diagnostic model based on these two hub genes can predict the risk of sarcopenia in patients with OSA.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2640269"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone deficiency in aging males: a dual threat to vascular and bone health through coronary artery calcification and osteoporosis - a narrative review.","authors":"Shijun Li","doi":"10.1080/13685538.2026.2662042","DOIUrl":"10.1080/13685538.2026.2662042","url":null,"abstract":"<p><p>Testosterone deficiency, a common condition in aging males, has been increasingly associated with two significant age-related conditions: coronary artery calcification (CAC) and osteoporosis. This comprehensive review examines the current evidence regarding the complex relationship between testosterone levels and these conditions in elderly male patients. We synthesize findings from recent studies exploring the pathophysiological mechanisms, clinical correlations, and potential therapeutic implications of testosterone status in cardiovascular and bone health. Evidence suggests that low testosterone levels are associated with increased coronary calcification burden, more advanced atherosclerotic plaques, and greater risk of osteoporotic fractures. The biological mechanisms connecting testosterone deficiency to these conditions include impaired lipid metabolism, chronic inflammation, endothelial dysfunction, disrupted bone remodeling processes, and altered calcium homeostasis. While observational studies consistently demonstrate associations between hypogonadism and worse cardiovascular and bone outcomes, results from interventional trials on testosterone replacement therapy (TRT) remain mixed, with some studies showing potential benefits for bone health but uncertain effects on cardiovascular risk. This review highlights the need for further research to establish causality, elucidate underlying mechanisms, and develop targeted therapeutic strategies for elderly men with testosterone deficiency affecting cardiovascular and skeletal systems.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2662042"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Chinese visceral adiposity index and bone mineral density in patients with type 2 diabetes mellitus.","authors":"Yuan Ruan, Lei Shi","doi":"10.1080/13685538.2026.2662050","DOIUrl":"10.1080/13685538.2026.2662050","url":null,"abstract":"<p><strong>Background: </strong>The relationship between visceral adiposity and bone mineral density (BMD) in type 2 diabetes (T2DM) remains inconsistent, potentially influenced by glycemic control. The Chinese Visceral Adiposity Index (CVAI) is a validated surrogate marker for visceral fat, but its association with BMD in T2DM is unexplored.</p><p><strong>Methods: </strong>This cross-sectional study of 202 T2DM patients (aged ≥40 years) assessed BMD via DXA. CVAI was calculated from age, BMI, waist circumference, triglycerides, and HDL-C. Participants were stratified by glycemic control (HbA1c < 9% vs. ≥9%). Associations were analyzed using correlation and multivariate linear regression.</p><p><strong>Results: </strong>Higher CVAI correlated with increased BMD at the lumbar spine (<i>r</i> = 0.184) and total hip (<i>r</i> = 0.269). This positive association was significant only in patients with HbA1c < 9% (total hip: <i>r</i> = 0.310) but absent in those with HbA1c ≥9%. CVAI remained an independent positive predictor of total hip BMD (β = 0.358, <i>P</i> < 0.001) after adjusting for age and sex.</p><p><strong>Conclusion: </strong>A moderate level of visceral adiposity, indicated by CVAI, may be associated with higher BMD in T2DM patients with better glycemic control. Optimal glucose management appears critical for preserving this potential skeletal benefit.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2662050"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between COVID-19 status and Leydig cell functional capacity among men in hospitalized cohorts.","authors":"Ravinder Anand-Ivell, Xinyuan Yang, Alexander W Tarr, William I Irving, David J Clark, Henry M Staines, Yolanda Augustin, Sanjeev Krishna, Richard Ivell","doi":"10.1080/13685538.2026.2650000","DOIUrl":"10.1080/13685538.2026.2650000","url":null,"abstract":"<p><strong>Background: </strong>The first wave of the COVID-19 pandemic in the UK in 2020 led to significant morbidity, hospitalization, and death, particularly amongst elderly men. Recent meta-analyses confirmed that SARS-CoV-2 infection led to reduced testosterone and increased LH, suggestive of testicular Leydig cell involvement.</p><p><strong>Methods: </strong>The unique Leydig cell biomarker insulin-like peptide 3 (INSL3) was measured in two cohorts of hospitalized men in Nottingham and London with moderate to severe COVID-19 symptoms.</p><p><strong>Results: </strong>For Nottingham men, circulating INSL3 was reduced at entry (0.36  0.34 ng/ml; <i>n</i> = 143), indicative of primary hypogonadism, but appeared to recover to normal values after treatment. For the less severely affected London men, INSL3 at entry was within the normal range (0.89 <u>+</u> 0.30 ng/ml; <i>n</i> = 43), though sequential blood sampling suggested a small decline thereafter, which recovered with treatment.</p><p><strong>Conclusion: </strong>In this first study of the biomarker INSL3 in hospitalized men with COVID-19, the results identify a Leydig cell deficiency and consequent hypogonadism as integral to the symptoms of the illness, which was most marked in severely ill patients. In most cases, Leydig cells appeared to recover with treatment. Whether Leydig cells are directly affected by SARS-CoV-2 virus or indirectly via systemic inflammation is unclear, though both are likely.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2650000"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between seminal and serum iron parameters and male infertility: a systematic review and meta-analysis.","authors":"Yannan Jiao, Yanlun Song, Jin Zhang, Yi Wei, Junli Wang","doi":"10.1080/13685538.2026.2719882","DOIUrl":"10.1080/13685538.2026.2719882","url":null,"abstract":"<p><strong>Background: </strong>Iron is an essential trace element for normal spermatogenesis, yet excessive iron accumulation may impair male fertility. Preliminary studies imply a link between elevated iron levels and male infertility, but evidence remains limited without systematic quantitative synthesis. This metaanalysis assessed the association between iron concentrations and male infertility.</p><p><strong>Methods: </strong>We systematically searched PubMed, CBM, CNKI and Cochrane Library. RevMan, Stata and R were used for data analysis. Randomeffects models pooled effect sizes, with forest and funnel plots generated to evaluate seminal and serum iron levels in male infertility.</p><p><strong>Results: </strong>After screening studies published up to April 2025, a total of ten eligible articles involving 985 participants were finally included in this meta-analysis. Pooled results revealed that seminal and serum iron concentrations were notably higher in infertile males compared with fertile controls. Specifically, infertile men presented higher seminal iron levels (SMD = 0.44, 95% CI: 0.12-0.76, <i>P</i> < 0.05), as well as elevated serum iron levels (SMD = 3.77, 95% CI: 1.68-5.87, <i>P</i> < 0.05). The present results suggest that increased seminal and serum iron concentrations may be potentially correlated with male infertility risk.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2719882"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between estimated glucose disposal rate and benign prostatic hyperplasia: results from two nationally representative population-based studies.","authors":"Haowen Liang, Hengxin Chen, Ying Wei","doi":"10.1080/13685538.2026.2717454","DOIUrl":"https://doi.org/10.1080/13685538.2026.2717454","url":null,"abstract":"<p><strong>Background: </strong>Benign prostatic hyperplasia (BPH), a prevalent condition among older men, has not been sufficiently explored in terms of its association with the estimated glucose disposal rate (eGDR) within American and Chinese populations.</p><p><strong>Methods: </strong>Data from the China Health and Retirement Longitudinal Study (CHARLS) and the National Health and Nutrition Examination Survey (NHANES) were examined. We computed indices pertinent to eGDR for every participant and subsequently utilized multivariate regression, restricted cubic splines (RCS), subgroup analysis, and mediation analysis.</p><p><strong>Results: </strong>This study included 4382 CHARLS participants and 3463 NHANES participants. In our study, we found that an inverse relationship was found between eGDR and BPH in both the CHARLS and NHANES populations. RCS revealed a significant linear relationship between eGDR and BPH in both study populations. Subgroup analyses showed that the effect of eGDR on BPH risk was consistent across all the examined subgroups. The mediation effect model in the NHANES population showed that the mediating effect of monocyte was significant at -15.14% (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Our research shows a negative link between eGDR and the risk of BPH in elderly American and Chinese males, with monocytes potentially acting as a partial mediator in this relationship.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2717454"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}