Aging Male最新文献

{"title":"Temporal and Spatial Analysis of Alzheimer's Disease Based on an Improved Convolutional Neural Network and a Resting-State FMRI Brain Functional Network.","authors":"Haijing Sun, Anna Wang, Shanshan He","doi":"10.3390/ijerph19084508","DOIUrl":"10.3390/ijerph19084508","url":null,"abstract":"<p><p>Most current research on Alzheimer's disease (AD) is based on transverse measurements. Given the nature of neurodegeneration in AD progression, observing longitudinal changes in the structural features of brain networks over time may improve the accuracy of the predicted transformation and provide a good measure of the progression of AD. Currently, there is no cure for patients with existing AD dementia, but patients with mild cognitive impairment (MCI) in the prodromal stage of AD dementia may be diagnosed. The study of the early diagnosis of MCI and the prediction of MCI to AD transformation is of great significance for the monitoring of the MCI to AD transformation process. Despite the high rate of MCI conversion to AD, the neuropathological cause of MCI is heterogeneous. However, many people with MCI remain stable. Treatment options are different for patients with stable MCI and those with underlying dementia. Therefore, it is of great significance for clinical practice to predict whether patients with MCI will develop AD dementia. This paper proposes an improved algorithm that is based on a convolution neural network (CNN) with residuals combined with multi-layer long short-term memory (LSTM) to diagnose AD and predict MCI. Firstly, multi-time resting-state fMRI images were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database for preprocessing, and then an AAL brain partition template was used to construct a 90 × 90 functional connectivity (FC) network matrix of a whole-brain region of interest (ROI). Secondly, the diversity of training samples was increased by generating an adversarial network (GAN). Finally, a CNN with residuals and a multi-layer LSTM model were constructed to automatically classify and predict the functional adjacency matrix. This method can not only distinguish Alzheimer's disease from normal health conditions at multiple time points, but can also predict progressive MCI (pMCI) and stable MCI (sMCI) at multiple time points. The classification accuracies in AD vs. NC and sMCI vs.pMCI reached 93.5% and 75.5%, respectively.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Androgen deprivation therapy and depression in the prostate cancer patients: review of risk and pharmacological management","authors":"Abdulrahman M Alwhaibi, Sary Alsanea, Bana Almadi, Jawza Al-sabhan, F. Alosaimi","doi":"10.1080/13685538.2022.2053954","DOIUrl":"https://doi.org/10.1080/13685538.2022.2053954","url":null,"abstract":"Abstract Purpose: Despite the effectiveness of androgen deprivation therapy in advanced prostate cancer, serious neuropsychiatric consequences in androgen deprivation therapy (ADT)-treated patients, mainly depression, have been concerning and gained more attention recently. This narrative review aims to shed light on the risk and pharmacological management of ADT-induced depression in PCa patients. Methods: We searched PubMed, Scopus and Google Scholar databases using MESH keywords “Prostate cancer OR prostate neoplasm” AND “Depression” AND “Androgen Deprivation Therapy” AND “antidepressants”. Search was limited to English and studies conducted on humans. Studies’ titles and abstracts were screened, and further information were obtained from the text, if necessary, to decide whether studies are to be included in this review. Results: Our review revealed 23 studies confirming the occurrence and worsening of depressive symptoms in ADT-treated patients, which frequently require pharmacological interventions; whereas 10 studies indicated otherwise. All studies were prospective, retrospective, cross-sectional or case reports. Based on the incidence of depression provided by the observational studies, the average among ADT-treated patients was 18.23% (range: 2.1–46.9%), while it was 8.42% (range: 1.4–23.3%) in the non-ADT patients. Although several treatments have been used for depression in cancer patients, current knowledge lacks observational and controlled studies as well as clinical guidelines that demonstrate efficacy and safety of antidepressants and guide clinicians to the appropriate treatment in these patients, respectively. On the other side, a few clinical studies have been published regarding the efficacy of selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors and/or saftey on other ADT associated adverse effects. Conclusions: Our work supports the recent attention towards mood issues as an adverse effect of ADT, and that greater awareness of this is warranted among clinicians. Clinical studies published regarding the use of antidepressants for other ADT associated adverse effects established the foundation that can be adopted to examine these therapies on ADT-induced depression.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"101 - 124"},"PeriodicalIF":2.6,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42249555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male subclinical hypogonadism and late-onset hypergonadotrophic hypogonadism: mechanisms, endothelial function, and interplay between reproductive hormones, undercarboxylated osteocalcin, and endothelial dysfunction","authors":"R. Matta, Hazem Mohamed Farrage, Ahmed Abdelfadel Saedii, M. Abdelrahman","doi":"10.1080/13685538.2022.2049744","DOIUrl":"https://doi.org/10.1080/13685538.2022.2049744","url":null,"abstract":"Abstract Background Pathogenesis and endothelial function in subclinical hypogonadism (SCH) remain unclear. Undercarboxylated osteocalcin (ucOC) participates in atherosclerosis and reproduction. We explored the underlying mechanisms and interplay of endothelial dysfunction, unOC and reproductive hormones in SCH and primary late-onset hypogonadism (LOH). Methods In the SCH, LOH, and healthy eugonadal male groups, we measured serum unOC, calculated luteinizing hormone/testosterone (LH/T), LH.T product, and estradiol/T (E/T) as indicators of impaired Leydig cells, androgen sensitivity index (ASI), and aromatase activity, respectively (LH set-point regulators), and assessed flow-mediated dilation of the brachial artery (FMD%), carotid-intima media thickness (CIMT), and aortic stiffness (AS). Results ↑LH/T, ↑ASI, ↓aromatase activity, normal T, follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) levels, ↑unOC, and enhanced atherosclerotic markers (↓FMD%, ↑CIMT, ↑AS) are characteristics of SCH. Testosterone was positively correlated with FMD% in SCH. The independent predictors were: SHBG and LH for FMD% and CIMT, respectively, and LH/T, ucOC, FSH, estradiol, and E/T ratio for AS in the LOH group; and LH for FMD% & AS and LH and LH/T for CIMT in all study subjects. Conclusions SCH is a distinct clinical entity characterized by impaired androgen sensitivity and aromatase activity, compensatory elevated unOC, endothelial dysfunction, and anti-atherogenic role of testosterone.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"79 - 94"},"PeriodicalIF":2.6,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47474894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between histological prostatitis and benign prostatic hyperplasia: a single-center retrospective study","authors":"Jinze Li, Yunxiang Li, D. Cao, Yin Huang, Lei Peng, Chunyang Meng, Qiang Wei","doi":"10.1080/13685538.2022.2050360","DOIUrl":"https://doi.org/10.1080/13685538.2022.2050360","url":null,"abstract":"Abstract Objective To investigate the relationship between histological prostatitis (HP) and clinical parameters related to benign prostatic hyperplasia (BPH) in male. Method The clinical data of 196 BPH patients who underwent transurethral resection of the prostate were collected. According to the results of hematoxylin-eosin (H&E) staining of prostate tissue, patients were divided into two groups: BPH with HP group and BPH without HP group. Differences in acute urinary retention (AUR), prostate volume (PV), serum sex hormones, lower urinary tract symptoms (LUTS) related parameters, and systemic inflammation indicators were compared between the two groups. SPSS software v.25 was used for statistical analysis. Results Compared with the BPH without HP group, the BPH with HP group had greater AUR rate, PV, total IPSS, and IPSS-storage in BPH with HP group (p < 0.05). However, there were no significant differences in IPSS-voiding, post-void residual volume, maximum urinary flow rate, serum sex hormones, and systemic inflammation indicators between the two groups (p > 0.05). Conclusions This study suggests that patients with HP have larger PV, more severe LUTS, and a higher risk of AUR. HP is closely related to BPH and may be a key factor in the occurrence and clinical progress of BPH.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"95 - 100"},"PeriodicalIF":2.6,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45842460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of routine assessment of free testosterone for the diagnosis of functional male hypogonadism","authors":"P. Facondo, Elena Di Lodovico, L. Pezzaioli, C. Cappelli, A. Ferlin, A. Delbarba","doi":"10.1080/13685538.2022.2046727","DOIUrl":"https://doi.org/10.1080/13685538.2022.2046727","url":null,"abstract":"Abstract Objective To investigate whether routine assessment of free testosterone improves the diagnostic accuracy of functional hypogonadism. Methods Total and free testosterone (calculated on SHBG levels) were determined in 188 patients with sexual symptoms and 184 with infertility. Results Hypogonadism (calculated free testosterone <63 pg/ml) was found in 47/188 (25.0%) patients with sexual symptoms and in 21/184 (11.4%) with infertility. Total testosterone determination misdiagnosed hypogonadism in 8.4% (12/143) of men with sexual symptoms and in 2% (3/152) with infertility. In subjects with borderline total testosterone, only 24.7% (19/77) had hypogonadism confirmed by free testosterone levels. Free testosterone levels significantly correlated with age, haematocrit, gonadotropins, gynecomastia, BMI, and number of co-morbidities, whereas total testosterone associated only with the latter two. Furthermore, age, haematocrit, BMI, and the presence of erectile dysfunction and of low libido were significantly different between men with normal and low free testosterone, whereas only BMI and low libido were significantly different between patients with normal and low total testosterone. Conclusion Routine assessment of free testosterone allows a more accurate diagnosis of functional hypogonadism, especially in men with sexual symptoms. Free testosterone levels associate with clinical and biochemical parameters of androgen deficiency better than total testosterone levels.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"25 1","pages":"72 - 78"},"PeriodicalIF":2.6,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46453971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is erectile dysfunction an early clinical symptom of chronic kidney disease?","authors":"Abdullah Cirakoglu,&nbsp;Ahmet Yuce,&nbsp;Erdal Benli,&nbsp;Yeliz Kasko Arici,&nbsp;Harun Dugeroglu,&nbsp;Ercan Ogreden","doi":"10.1080/13685538.2021.1936483","DOIUrl":"https://doi.org/10.1080/13685538.2021.1936483","url":null,"abstract":"<p><strong>Objectives: </strong>Erectile dysfunction (ED) is the persistent inability to attain and/or maintain erection sufficient for satisfactory sexual performance. Chronic kidney disease (CKD) is a problem with increasing incidence every day which disrupts quality of life significantly. We aimed to research whether ED is a warning symptom for the early stages of CKD or not.</p><p><strong>Materials and methods: </strong>The records of 639 patients attending Ordu University due to ED were retrospectively investigated. According to International Index of Erectile Function (IIEF) scores and degree of ED, patients were compared in terms of GFR values.</p><p><strong>Results: </strong>In 92.8% of patients, serum creatinine values were within normal limits (<1 mg/dL), while 30.5% of patients were observed to have GFR below 80. While stage 2 CKD was identified in 1% of the control group, this rate was calculated as 8% in the group with severe ED. In stage 1 and stage 2 CKD, IIEF scores were identified to be low by clear degree.</p><p><strong>Conclusions: </strong>Results confirm that it was identified that the incidence of stage 1 and stage 2 CKD was higher among patients attending with ED compared to the control group. Just as ED may be an early clinical marker of coronary artery disease, it may be early warning symptom for CKD.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"24-28"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2021.1936483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39068161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological testosterone replacement effects on male aged rats with orchiectomy-induced osteoporosis in advanced stage: a tomographic and biomechanical pilot study.","authors":"Vinícius de Paiva Gonçalves,&nbsp;Adriana Alicia Cabrera-Ortega,&nbsp;Jhonatan de Souza Carvalho,&nbsp;Dania Ramadan,&nbsp;Luís Carlos Spolidorio","doi":"10.1080/13685538.2021.1990256","DOIUrl":"https://doi.org/10.1080/13685538.2021.1990256","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to evaluate the effect of physiological testosterone replacement on male aged rats with orchiectomy-induced osteoporosis in advanced stage.<b>Methods:</b> Thirty male rats (<i>Rattus norvegicus albinus</i>, Holtzman lineage) were randomly distributed into 3 groups (<i>n</i> = 10): 1-sham, 2-orchiectomy (OCX), 3-OCX + testosterone replacement (OCX + T). On day 0, a sham or orchiectomy surgery was performed according to the groups. Thirty and sixty days after surgeries, the animals from OCX + T group received testosterone intramuscularly, and the rats in all groups were euthanized on day 77. The femurs were removed for micro-CT scanning and biomechanical test.<b>Results:</b> Orchiectomy resulted in a marked trabecular bone damage (<i>p <</i> 0.05), which was not reversed with testosterone treatment (OCX + T group). The femoral strength was lower in orchiectomized animals (<i>p <</i> 0.05), while the bone strength in OCX + T group was similar to that observed in the sham animals (<i>p</i> > 0.05) and correlated to this parameter the deformation of rupture was smaller in OCX + T group.<b>Conclusion:</b> In conclusion, testosterone depletion induced by orchiectomy established an osteoporotic environment, mainly affecting the trabecular bone. Moreover, even though testosterone treatment did not enhance these variables, the hormonal replacement improved the femoral fracture strength and promoted beneficial effects on the biomechanical parameters compromised by castration in femoral bone.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"139-147"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39516558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary spinal cord changes and spinal deformity following traumatic spinal cord injury.","authors":"Mohammad Ahmad Jamous,&nbsp;Raed Awni Jaradat,&nbsp;Mustafa Mohamed Alwani","doi":"10.1080/13685538.2020.1800631","DOIUrl":"https://doi.org/10.1080/13685538.2020.1800631","url":null,"abstract":"<p><p>Secondary spinal cord changes can follow spinal cord injuries (SCIs). This retrospective study was to uncover the chronic secondary changes that affect the spinal cord following severe injuries and to evaluate the influence of residual spinal deformity in the development of posttraumatic spinal cord changes. Fifty-eight patients (39 male, 19 female) with complete traumatic SCI and recent Magnetic resonance imaging (MRI) follow-up were reviewed retrospectively. A minimum of 2 years duration between trauma and MRI study was required (mean 2.9 years [2.1-4.7]). Two groups of patients were formed: with spinal deformity (and or spinal canal compromise) and without spinal deformity (and or spinal canal compromise). MRI of the injured spine demonstrated four major types of spinal cord changes; these are spinal cord atrophy, myelomalacia, syrinx, and focal cyst formation. The correlation of these changes to the presence of spinal deformity and or spinal canal compromise was also studied. Twenty-three patients (40%) of the studied population had more than 30° kyphosis and or 50% compromise of the spinal canal. Chronic spinal cord changes occurred in 25 patients (43%), 17 of these changes occurred in patients with spinal deformity and the remaining 8 occurred in patients without spinal deformity or canal compromise (<i>p</i> ≤ .05). The prevalence of spinal cord atrophy and focal cysts was significantly higher in patients with residual deformity and or spinal canal compromise (<i>p</i> ≤ .05). The authors recommend proper spinal cord decompression and fixation for patients with complete SCI to reduce the chance of secondary SCI.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"95-100"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1800631","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39262482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations on the diagnosis, treatment and monitoring of testosterone deficiency in men.","authors":"Bruno Lunenfeld,&nbsp;George Mskhalaya,&nbsp;Michael Zitzmann,&nbsp;Giovanni Corona,&nbsp;Stefan Arver,&nbsp;Svetlana Kalinchenko,&nbsp;Yuliya Tishova,&nbsp;Abraham Morgentaler","doi":"10.1080/13685538.2021.1962840","DOIUrl":"https://doi.org/10.1080/13685538.2021.1962840","url":null,"abstract":"<p><p>The relative proportional increase of the elderly population within many countries will become one of the most significant social transformations of the twenty-first century and, for the first time in history, persons aged 65 or above outnumbered children under five years of age globally. One in four persons living in Europe and Northern America will be aged 65 or over. One of the goals of ISSAM is to raise awareness of the special health needs of older men. Since a significant number of aging men will eventually become testosterone deficient, the Hypogonadism panel of ISSAM updates its guidelines.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"119-138"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficiency of prostate-specific antigen density measurement using three different methods on the prediction of biochemical recurrence.","authors":"Yavuz Onur Danacioglu,&nbsp;Ferhat Keser,&nbsp;Özgür Efiloğlu,&nbsp;Meftun Culpan,&nbsp;Salih Polat,&nbsp;Ramazan Gokhan Atis,&nbsp;Asif Yildirim","doi":"10.1080/13685538.2021.1924667","DOIUrl":"https://doi.org/10.1080/13685538.2021.1924667","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the efficiency of prostate-specific antigen (PSA) density (PSAD) calculated through prostate volume (PV) obtained <i>via</i> transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) and actual prostate weight (PW) methods obtained <i>via</i> pathological evaluation on the prediction of biochemical recurrence (BCR) in the follow-ups of patients who had undergone radical prostatectomy (RP).</p><p><strong>Methods: </strong>A total of 335 clinically localized prostate cancer (PCa) patients who had received open RP between January 2015 and December 2018 were enrolled in the study. Pre and postoperative demographic data, clinical and pathological findings and BCR conditions were recorded. The PSAD was calculated using information obtained through preoperative TRUS examinations, MRI, and collected pathological specimens after RP by dividing the maximum preoperative PSA value and PV/PW.</p><p><strong>Results: </strong>In a mean follow-up duration of 20.2 ± 8.5 months, recurrence was observed in 52 patients (24.4%) and progression was observed in 8 (3.8%) patients. The TRUS-PSAD, MRI-PSAD, and PW-PSAD values were statistically significantly higher in BCR patients compared to non-BCR patients. The International Society of Urologic Pathologists (ISUP) grade 5 and pT3b as a pathological stage were detected as independent variables in the prediction of BCR formation. Actual PW had a high prediction value compared to other PSAD measurements at <40 g prostate weights, but it had a low prediction value in prostates with an actual PW >60 g.</p><p><strong>Conclusions: </strong>In this study, it was stated that PSAD acquired through different imaging methods does not affect the usability of PSAD in BCR prediction in clinical practice. The ISUP grade 5 and pT3b stage PCa were detected as independent markers in BCR prediction after RP.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"15-23"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2021.1924667","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38995668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}