Aging Male最新文献_第6页

Association of physical activity and hip fracture in chinese middle-aged and older adults: a prospective cohort study. 中国中老年人体力活动与髋部骨折的关系：一项前瞻性队列研究。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-31 Epub Date: 2025-12-19 DOI: 10.1080/13685538.2025.2604393

Jie Yang, Hao Jia, Kai Yu, Baoqi Zeng

{"title":"Association of physical activity and hip fracture in chinese middle-aged and older adults: a prospective cohort study.","authors":"Jie Yang, Hao Jia, Kai Yu, Baoqi Zeng","doi":"10.1080/13685538.2025.2604393","DOIUrl":"10.1080/13685538.2025.2604393","url":null,"abstract":"Background: To investigate the associations between various patterns of physical activity (PA) and risk of hip fracture in Chinese middle-aged and older adults.Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2020. PA levels, including moderate-to-vigorous (MVPA), vigorous (VPA), moderate (MPA), low (LPA), and total physical activity (TPA), were assessed using the International Physical Activity Questionnaire. Cox proportional hazard models were used to estimate hazard ratios (HRs), and a restricted cubic spline analyzed the dose-response relationship between TPA and hip fracture.Results: Among 6,193 participants (mean age 59.3; 54.0% female), 264 hip fractures occurred during follow-up. Meeting WHO-recommended MVPA levels ≥150 min/week) was not associated with reduced risk (HR 1.04, 95% CI 0.80-1.35). Similarly, no significant associations were observed for VPA (≥75 min/week), MPA (≥150 min/week), LPA (≥300 min/week), or TPA (≥600 MET-min/week). Dose-response analysis also showed no association between total PA and hip fracture.Conclusion: This study does not support the WHO recommendation of ≥ 150 min/week of MVPA for reducing hip fracture risk in this demographic. As PA was self-reported and largely work-related, future research should investigate leisure-time and objectively-measured PA.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2604393"},"PeriodicalIF":2.6,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The aging male: a year of expansion, integration, and intellectual cross-pollination. 老年男性：是扩张、融合和智力交流的一年。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-12-04 DOI: 10.1080/13685538.2025.2596501

Michael Zitzmann

引用次数: 0

Association between hypertension and kidney stones: a cross-sectional analysis from NHANES and Mendelian randomization. 高血压和肾结石之间的关系：来自NHANES和孟德尔随机化的横断面分析。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-10-24 DOI: 10.1080/13685538.2025.2571937

Shan He, Yi Wei Chen, Lian Ying Hu, Qin Kai Chen, Yu Wang, Si Yi Liu

{"title":"Association between hypertension and kidney stones: a cross-sectional analysis from NHANES and Mendelian randomization.","authors":"Shan He, Yi Wei Chen, Lian Ying Hu, Qin Kai Chen, Yu Wang, Si Yi Liu","doi":"10.1080/13685538.2025.2571937","DOIUrl":"https://doi.org/10.1080/13685538.2025.2571937","url":null,"abstract":"Background: The association between hypertension and kidney stones remains inconsistent. This research investigated the relationship between hypertension and the risk and progression of kidney stones.Methods: A cross-sectional analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES). The association was assessed with a multivariable logistic regression model. Furthermore, a two-sample Mendelian randomization (MR) analysis was conducted to evaluate causality. Methods included inverse-variance weighted (IVW), weighted median, and sensitivity analyses. Summary-level data for kidney stones were obtained from the UK Biobank, and for hypertension from a genome-wide association study (GWAS)analysis.Results: The NHANES analysis included 21,740 participants. After full adjustment, hypertension was significantly associated with a higher prevalence of kidney stones (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.19-1.56, p < 0.001). In the MR analysis, the IVW method indicated a causal effect of hypertension on kidney stones (OR = 1.01, 95% CI: 1.00-1.01, p = 0.013), supported by the weighted median method (OR = 1.01, 95% CI: 1.00-1.02, p = 0.002). Sensitivity analyses revealed no significant heterogeneity or pleiotropy.Conclusions: Our investigation revealed a heightened risk of kidney stones linked to hypertension, which necessitates validation through further large-scale prospective cohort studies.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2571937"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher charlson comorbidity index is associated with increased risk of erectile dysfunction: evidence from NHANES data. 较高的charlson合并症指数与勃起功能障碍风险增加相关：来自NHANES数据的证据。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-11-12 DOI: 10.1080/13685538.2025.2581661

Xiaobao Chen, Junwei Lin, Binhong Liu, Lingjun Liu, Wei Jiang, Ruoyun Xie

{"title":"Higher charlson comorbidity index is associated with increased risk of erectile dysfunction: evidence from NHANES data.","authors":"Xiaobao Chen, Junwei Lin, Binhong Liu, Lingjun Liu, Wei Jiang, Ruoyun Xie","doi":"10.1080/13685538.2025.2581661","DOIUrl":"10.1080/13685538.2025.2581661","url":null,"abstract":"Background: The Charlson Comorbidity Index (CCI) quantifies multimorbidity, but its link to erectile dysfunction (ED) remains underexplored.Methods: Using data from the National Health and Nutrition Examination Survey (NHANES), our study investigated the association between CCI and ED. Our analysis involved weighted multivariate regression, subgroup analyses, restricted cubic spline (RCS) analyses, and propensity score matching (PSM) analyses.Results: Among the 2295 adults included in this study, 863 (37.6%) were diagnosed with ED. Weighted multivariate regression analyses revealed a significant positive association between the CCI and the risk of ED. Each additional point on the CCI was associated with a 32% higher risk of ED (OR 1.32, 95% CI 1.18-1.47). Furthermore, when participants were categorized into two groups based on CCI scores (CCI = 0 and CCI ≥ 1), the risk of ED was notably higher for those with CCI ≥ 1, showing a 122% increased risk compared to those with CCI = 0 (OR 2.22, 95% CI 1.62-3.05). Sensitivity analyses, including subgroup analyses and PSM, consistently supported the strong positive correlation between the CCI and ED.Conclusion: Our study indicates that a higher CCI is positively correlated with an increased risk of ED, suggesting that lower CCI scores are associated with lower risk of ED.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2581661"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological aging matters: a cross-sectional study uncovering the association between phenotypic age acceleration and erectile dysfunction based on 2360 male individuals. 生物学衰老问题：一项横断面研究揭示了基于2360名男性个体的表型年龄加速和勃起功能障碍之间的关联。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-11-17 DOI: 10.1080/13685538.2025.2576049

Fan Dong, Ping Ping, Yi Ma, Xiang-Feng Chen

{"title":"Biological aging matters: a cross-sectional study uncovering the association between phenotypic age acceleration and erectile dysfunction based on 2360 male individuals.","authors":"Fan Dong, Ping Ping, Yi Ma, Xiang-Feng Chen","doi":"10.1080/13685538.2025.2576049","DOIUrl":"https://doi.org/10.1080/13685538.2025.2576049","url":null,"abstract":"Background: The current study aimed to explore the potential associations between Phenotypic Age (PhenoAge)/PhenoAge acceleration (PhenoAgeAccel) and erectile dysfunction (ED).Methods: We carried out a cross-sectional study based on data from 2360 male participants from the National Health and Nutrition Examination Survey program in the year 2001-2004. ED was evaluated according to a self-administered questionnaire. PhenoAge and PhenoAgeAccel were employed to evaluate the biological aging speed as previously reported. Weighted logistic regression analyses were performed to reveal the association between either PhenoAge or PhenoAgeAccel and ED. We also applied restricted cubic spline (RCS) models to explore the non-linearity in such associations. Sensitivity analyses were performed to detect the robustness of the main finding.Results: Significantly higher PhenoAge and PhenoAgeAccel were observed in participants with ED compared with no ED group (both p < 0.0001). Multivariate logistic analyses exhibited significant associations of both PhenoAge and PhenoAgeAccel, either in continuous or categorical forms, with ED, with comprehensive adjustment. RCS models revealed the non-linear relationship between either PhenoAge or PhenoAgeAccel and ED. Sensitivity analyses showed the associations between PhenoAge/PhenoAgeAccel and ED remained significant.Conclusions: Our results suggested a significantly positive association between either PhenoAge or PhenoAgeAccel and ED. Future researches are needed to verify our findings.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2576049"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The male hormone reset: how GLP-1RAs, lifestyle and testosterone transform obesity-linked problems. 男性荷尔蒙重置：GLP-1RAs、生活方式和睾丸激素如何改变与肥胖相关的问题。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-12-15 DOI: 10.1080/13685538.2025.2601423

Kristina Groti Antonič, Michael Zitzmann

{"title":"The male hormone reset: how GLP-1RAs, lifestyle and testosterone transform obesity-linked problems.","authors":"Kristina Groti Antonič, Michael Zitzmann","doi":"10.1080/13685538.2025.2601423","DOIUrl":"https://doi.org/10.1080/13685538.2025.2601423","url":null,"abstract":"Introduction: Functional hypogonadism, a manifestation of testosterone deficiency in simultaneously present comorbidities, profoundly impairs quality of life in men with overweight and obesity - yet remains persistently under-recognized in clinical practice.Findings: Lifestyle modification constitutes first-line therapy, while pharmacological and surgical interventions increasingly complement it. Both promote substantial weight loss and may reverse obesity-related hypogonadism; bariatric surgery, in particular, elicits marked rises in circulating testosterone but entails risks of bone demineralization and uncertain long-term reproductive sequelae. Notwithstanding, testosterone deficiency itself represents a key driver of secondary osteoporosis, insulin resistance, anemia, fatigue, and depression as well as sexual symptoms. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have redefined obesity therapy through profound weight reduction and cardiometabolic benefit, yet concomitant losses of lean mass raise concern over sarcopenia and skeletal fragility.Conclusion: This focused review article aims to present a comprehensive update on the latest data concerning combining testosterone therapy with contemporary anti-obesity pharmacotherapy as a new standard of care for obese men with functional hypogonadism, uniting metabolic, vascular, sexual, cognitive, and skeletal benefits within a comprehensive strategy to fortify corporeal resilience and enhance quality of life.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2601423"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between monocyte-to-high-density lipoprotein cholesterol ratio and total testosterone and testosterone deficiency in men. 男性单核细胞与高密度脂蛋白胆固醇比值与总睾酮和睾酮缺乏之间的关系。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 DOI: 10.1080/13685538.2025.2598718

Hongyuan Chang, Hao Wang, Anmin Wang, Di Sun, Ziwei Zhao, Dongyue Ma, Hui Lv, Shihao Wang, Jun Guo, Fu Wang

{"title":"Association between monocyte-to-high-density lipoprotein cholesterol ratio and total testosterone and testosterone deficiency in men.","authors":"Hongyuan Chang, Hao Wang, Anmin Wang, Di Sun, Ziwei Zhao, Dongyue Ma, Hui Lv, Shihao Wang, Jun Guo, Fu Wang","doi":"10.1080/13685538.2025.2598718","DOIUrl":"https://doi.org/10.1080/13685538.2025.2598718","url":null,"abstract":"Background: The monocyte-to-high-density lipoprotein cholesterol ratio (MHR), an indicator of inflammation and lipid metabolism, has demonstrated significant clinical potential. The study aims to investigate the association between the MHR and total testosterone (TT) levels, as well as testosterone deficiency (TD) risk, utilizing data from the NHANES.Methods: We analyzed data from 6,194 adult men from NHANES 2011-2016. Multivariate linear and logistic regression analyses were conducted to evaluate associations of MHR with TT levels and TD risk, respectively. Restricted cubic spline (RCS) analyses and subgroup analyses further assessed the robustness of our findings.Results: In the fully adjusted model, each unit increase in log-transformed MHR was associated with a decrease in TT (β = -47.91, 95% CI: -62.39, -33.43, P < 0.001) and an increase in TD risk (OR = 1.81, 95% CI: 1.46, 2.24, P < 0.001). RCS analysis confirmed a linear relationship, and the findings were consistent across subgroup analyses.Conclusions: This study showed that in the United States (US) adult men, a high MHR is linked to low TT levels and a higher TD risk. These findings suggest MHR could be a useful marker for early detection of low testosterone and TD risk, warranting further prospective research for confirmation.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2598718"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk-dependent decision-making for circumcision in penile corporoplasty: type-2 diabetes mellitus associated with post-surgical phimosis. 阴茎体成形术中包皮环切的风险依赖决策：2型糖尿病与术后包茎相关。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-11-27 DOI: 10.1080/13685538.2025.2591471

Ron Pascal Wolf, Sabine Kliesch, Michael Zitzmann, Maria Schubert, Jann-Frederik Cremers

{"title":"Risk-dependent decision-making for circumcision in penile corporoplasty: type-2 diabetes mellitus associated with post-surgical phimosis.","authors":"Ron Pascal Wolf, Sabine Kliesch, Michael Zitzmann, Maria Schubert, Jann-Frederik Cremers","doi":"10.1080/13685538.2025.2591471","DOIUrl":"https://doi.org/10.1080/13685538.2025.2591471","url":null,"abstract":"Introduction: Corporoplasty is typically accompanied by circumcision to prevent complications such as phimosis, foreskin edema, and necrosis, yet supporting evidence is limited. We reassessed the need for concomitant circumcision by quantifying postoperative phimosis and exploring associated comorbidities.Methods: In this single-centre retrospective cohort study, 69 of 191 men who underwent corporoplasty between 2010 and 2023 met predefined criteria. Patients with incomplete records, refusal to participate, or loss to follow-up were excluded. Data collection involved the administration of a questionnaire to patients, supplemented by data retrieved from medical databases. The median age was 55 years (range 17-70 years).Results: 48 of 69 patients did not undergo circumcision either before or during the corporoplasty. Only 3 out of the 48 patients (6.25%) developed post-surgical phimosis. No post-surgical foreskin necrosis were reported. A relevant finding was type2 diabetes mellitus as a significant risk factor for post-surgical phimosis (p < 0.0038). Additionally, the negative impact of the degree of curvature on post-surgical glans penis sensitivity was identified (p = 0.027).Conclusion: Our findings advocate against the obligatory practice of circumcision performing corporoplasty. Nonetheless, our results emphasize the importance of counseling patients with type2 diabetes mellitus due to their heightened susceptibility to post-surgical phimosis development.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2591471"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and management of male hypogonadism in Germany. 德国男性性腺功能减退症的诊断和治疗。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-12-15 DOI: 10.1080/13685538.2025.2602243

Michael Zitzmann, Diethe Ortius-Lechner, Nadine Thierfelder, Christian Schindler, Dennis Häckl

{"title":"Diagnosis and management of male hypogonadism in Germany.","authors":"Michael Zitzmann, Diethe Ortius-Lechner, Nadine Thierfelder, Christian Schindler, Dennis Häckl","doi":"10.1080/13685538.2025.2602243","DOIUrl":"10.1080/13685538.2025.2602243","url":null,"abstract":"Background: The extent to which male hypogonadism is diagnosed and treated remains ambiguous. This study scrutinizes the respective medical framework in Germany.Materials and methods: This observational study retrospectively analyzes data from four million male state insurance clients, aged 30 to 80, from 2014 to 2021. It evaluates diagnostics related to hypogonadism prevalence, incidence, comorbidities, testosterone therapy (TTh) implementation, type 2 diabetes incidence, and work incapacity rates.Results: According to the diagnoses, the prevalence of primary hypogonadism (0.62%) exceeded that of secondary (0.16%) and functional hypogonadism (0.09%), with both incidence and prevalence rising from 2015 to 2021. Common comorbidities included primary hypertension, back pain, and dyslipidemia. Within the first year post-diagnosis, TTh (via transdermal or intramuscular administration) was initiated in 35.22%, 36.60%, and 59.55% of patients with primary, secondary, and functional hypogonadism, respectively. Untreated primary hypogonadism patients had higher work incapacity rates compared to treated patients (17.1% vs. 9.71%; p < 0.001). Conversely, treated patients had a higher incidence of newly diagnosed type 2 diabetes (24.0% vs. 17.7%; p < 0.001).Conclusion: Optimizing the diagnosis, treatment, and monitoring of male hypogonadism in clinical practice could enhance the quality of life for affected individuals and reduce societal costs.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2602243"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: erectile dysfunction in patients with obstructive sleep apnea: effects of continuous positive airway pressure. 评论：阻塞性睡眠呼吸暂停患者的勃起功能障碍：持续气道正压的影响。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-11-03 DOI: 10.1080/13685538.2025.2573215

Husnu Tokgoz, Ozlem Tokgoz

引用次数: 0