Aging Male最新文献

{"title":"Feasibility of robot-assisted radical prostatectomy in men at senior age ≥75 years: perioperative, functional, and oncological outcomes of a high-volume center.","authors":"Sami-Ramzi Leyh-Bannurah,&nbsp;Christian Wagner,&nbsp;Andreas Schuette,&nbsp;Nikolaos Liakos,&nbsp;Theodoros Karagiotis,&nbsp;Mikolaj Mendrek,&nbsp;Pawel Rachubinski,&nbsp;Matthias Oelke,&nbsp;Zhe Tian,&nbsp;Jorn H Witt","doi":"10.1080/13685538.2021.2018417","DOIUrl":"https://doi.org/10.1080/13685538.2021.2018417","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to assess whether age ≥75 years impairs surgical, functional, and oncological outcomes after robot-assisted radical prostatectomy (RARP).</p><p><strong>Materials and methods: </strong>Patients with prostate cancer (PCa) were stratified in ≥75(<i>n</i> = 669) vs. <70 years(<i>n</i> = 8,268). Multivariable cox regression analyses (MVA) tested for effect of senior age on erectile function-, urinary continence-recovery, biochemical recurrence (BCR), and metastatic progression (MP).</p><p><strong>Results: </strong>RARP duration, blood loss, and 30d complication rates were similar between groups. For patients ≥75 vs. <70 years, rates of erectile function after 36 and urinary continence after 12 months were 27 vs. 56% (<i>p</i> < 0.001) and 85 vs. 86% (<i>p</i> = 0.99), respectively. Mean quality of life (QoL) score after 12 months improved in both groups (<i>p</i> = 0.9). At 48 months, BCR- and MP-free rates were 77 vs. 85% (<i>p</i> < 0.001) and 97 vs. 98% (<i>p</i> = 0.3), respectively. MVA confirmed the negative effect of senior age on erectile function but no significant effect on urinary continence, BCR or MP, before and after propensity score matching.</p><p><strong>Conclusion: </strong>Apart from erectile function, senior age has no significant effect on urinary continence recovery, BCR- or MP-free rates after RARP. Post-RARP QoL improved even in senior patients. Modern therapy of senior PCa patients should be based on individual counseling than just age.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39766951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncologic impact of concomitant prostate cancer characteristics at the time of radical cystoprostatectomy for bladder cancer: a population-based analysis.","authors":"Mykyta Kachanov,&nbsp;Malte W Vetterlein,&nbsp;Armin Soave,&nbsp;Pierre I Karakiewicz,&nbsp;Nikolaos Liakos,&nbsp;Thomas Jankowski,&nbsp;Randi M Pose,&nbsp;Mikolaj Mandrek,&nbsp;Margit Fisch,&nbsp;Jorn H Witt,&nbsp;Markus Graefen,&nbsp;Sami-Ramzi Leyh-Bannurah","doi":"10.1080/13685538.2022.2040982","DOIUrl":"https://doi.org/10.1080/13685538.2022.2040982","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the prognostic impact of concomitant prostate cancer (PCa) of the cancer-specific mortality (CSM) in the aging patient's papulation with bladder cancer (BCa) treated with radical cystoprostatectomy (RCP).</p><p><strong>Materials and methods: </strong>Within the SEER database (2004-2015), 1468 patients were treated with RCP for BCa harboring histopathological PCa findings. To account for other cause mortality (OCM), multivariable competing risk regression (CRR) tested for potential BCa-CSM differences according to PCa characteristics risk factors predicting CSM.</p><p><strong>Results: </strong>CRR analysis revealed that only following BCa characteristics, as high pathological tumor stages(Ta/Tis/T1 [REF.] vs. T2; HR 2.03, 95% CI: 1.16-3.57, <i>p</i> = 0.014 vs. T3; HR 4.32, 95% CI: 2.45-7.61, <i>p</i> < 0.001 vs. T4; HR 5.06, 95% CI: 2.77-9.22, <i>p</i> < 0.001), as well unfavorable BCa grade IV (Grade I-II [REF.] vs. Grade IV; HR 0.58, 95% CI: 0.35-0.98, <i>p</i> < 0.041) achieved independent predictor status of CSM. With regard to PCa characteristics, none of the covariates yielded independent predictor status of CSM.</p><p><strong>Conclusions: </strong>Our study, based on the largest population cohort, demonstrates that even in organ-confined BCa patients, concomitant PCa as second malignancy does not represent a risk factor for survival.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39642701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of assessing male osteoporosis using MRI IDEAL-IQ sequence of proximal femur in prostate cancer patients.","authors":"Daisuke Watanabe,&nbsp;Takahiro Kimura,&nbsp;Kazuki Yanagida,&nbsp;Takahiro Yoshida,&nbsp;Norikazu Kawae,&nbsp;Takahiro Nakamura,&nbsp;Hajime Kajihara,&nbsp;Akio Mizushima","doi":"10.1080/13685538.2022.2112663","DOIUrl":"https://doi.org/10.1080/13685538.2022.2112663","url":null,"abstract":"<p><p>Osteoporosis is often accompanied by bone loss with fat accumulation of the red marrow. A novel technique for quantification of iron and fat content by MRI IDEAL-IQ can visualize hematopoietic areas and fatty deposits in bone marrow; however, the relationship between these indices and total hip bone mineral density (BMD) remains unclear. In this study, the proximal femur of 104 men who underwent pelvic MRI and bone densitometry prior to treatment for non-metastatic prostate cancer was retrospectively examined to investigate the R2* value to quantify iron and proton density fat fraction (PDFF) to assess bone marrow fat content. R2* was significantly positively correlated with BMD (<i>r</i> = 0.6017, <i>p</i> < 0.0001), and PDFF was not correlated with BMD (<i>r</i> = -0.1302, <i>p</i> = 0.0512). Patients with BMD T-score ≤ -2.5 had significantly lower R2* than patients with BMD T-score > -2.5; however, there was no significant difference in PDFF. In the ROC analysis, which examined the predictive ability of R2* with BMD T-score ≤ -2.5 as an outcome, the cut-off value of R2* was 50.7 <i>s</i>^-1 (AUC 0.817). These results show R2* correlated with BMD. R2* may be a non-invasive surrogate marker for diagnosing male osteoporosis.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40631726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brucellosis in older person: a case report from Qatar.","authors":"Hanadi Khamis Al Hamad,&nbsp;Navas Nadukkandiyil,&nbsp;Mohammed Al Husami,&nbsp;Hebatullah Ahmed Abdelgawad,&nbsp;Sanjeevikumar Meenakshisundaram,&nbsp;Osman Bashir Nemeri","doi":"10.1080/13685538.2022.2138851","DOIUrl":"https://doi.org/10.1080/13685538.2022.2138851","url":null,"abstract":"<p><strong>Background: </strong>Brucellosis is a multisystem disease with a broad spectrum of non-specific symptoms that generally occur within three weeks but sometimes up to 3 months after inoculation. Human brucellosis is quite uncommon in Elderly in Qatar.</p><p><strong>Case report: </strong>This report describes a case of Brucellosis in acute geriatric unit under Rumailah Hospital in Qatar. The patient was an 81-year-old Qatari Gentle man, functionally able to walk with minimal assistance and had mild cognitive impairment who presented with high-grade fever with chills, anorexia, low back pain and arthralgia for 10 days. The above complaints occurred often for 1 month and had fever intermittently. Lab investigations revealed as high CRP 117 mg/l, low Hb 9.1 g/dl and mild elevation in ALP (151 µ/l) with normal leukocyte and platelet count. His blood culture positive for <i>Brucella melitensis</i> with high brucella Antibody titter 1:1280. The diagnosis made as Brucellosis.</p><p><strong>Discussion: </strong>The clinical manifestations of Brucellosis are fever, night sweating, chills, arthralgia and loss of appetite. It seems pyrexia of unknown origin without other symptoms is most common presentation of Brucellosis in old age. The confirmation of Brucellosis made with serological tests, with significantly high titer, in the presence or absence of blood culture. Brucella antibody titers (≥1:160) are suggestive of active infection. Anemia and raised CRP and liver enzymes were the most prominent laboratory abnormalities in our patients. Previous study from Qatar reported that 41.7% had a history of raw milk consumption and 12.5% had a history of animal contact. The objectives of Brucellosis treatment include the prevention of complications and relapse.</p><p><strong>Conclusion: </strong>Our case presented with classical symptoms and received appropriate treatment on time. However, atypical clinical presentation and lack of specific history taking can delay diagnosis and treatment; it leads to serious clinical disease progression with increased complications. From this case study, we would contribute to optimal assessment and to keep differential diagnosis for unknown cause of fever can be Brucellosis in geriatric population.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9150202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second-to-fourth digit ratio and age predicting the severity of androgenetic alopecia: a cross-sectional study.","authors":"Wei-Chiao Chen,&nbsp;Wen-Li Hsu,&nbsp;Jeff Yi-Fu Chen,&nbsp;Nai-Hua Shih,&nbsp;Ching-Ying Wu","doi":"10.1080/13685538.2022.2119954","DOIUrl":"https://doi.org/10.1080/13685538.2022.2119954","url":null,"abstract":"<p><p><b>Purpose:</b> Androgenetic alopecia (AGA) is a common type of hair loss. Previous studies indicated that the relative length of the index and ring finger (2D:4D ratio) of AGA patients was lower than control. However, the correlation between 2D:4D ratio and disease severity is unclear. In this study, we sought to evaluate the relationship between digit ratio of the right hand and AGA severity in male patients.<b>Materials and methods:</b> The cross-sectional study was performed. Hamilton-Norwood scale was used to assess severity. The finger lengths of the right hand were measured using a digital caliper.<b>Results:</b> Our study found that the lower the right-handed 2D:4D ratio, the greater the risk of developing AGA and that the severity of AGA increases with age. Patients with moderate and severe AGA (grade 3 and above) had lower 2D:4D ratios and higher average age compared with patients with mild AGA (Norwood grade 2). Patients aged ≥37.5 with a 2D:4D ratio <0.947 were six times more likely to have moderate-to-severe androgenetic alopecia compared with the reference group (OR: 6.11; 95% CI: 1.96-19.04).<b>Conclusions:</b> Combining 2D:4D ratio and older age may help predict the severity risk of AGA, and offer a clinically accessible, non-invasive approach for patients to easily predict their future severity.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10511659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of resistance exercise on body composition and physical function in prostate cancer patients undergoing androgen deprivation therapy: an update systematic review and meta-analysis.","authors":"Siyu Tian,&nbsp;Meng Ding,&nbsp;Hongfu Sun","doi":"10.1080/13685538.2022.2146670","DOIUrl":"https://doi.org/10.1080/13685538.2022.2146670","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the meta-analysis was to explore effects of resistance exercise (RE) on body composition and physical function in patients with prostate cancer (PCa).</p><p><strong>Data sources: </strong>We searched the electronic databases of Pubmed, Embase, Cochrane, and web of science. Published studies have been collected from these databases. Search terms include <i>resistance training, strength training,</i> RE<i>, androgen suppression therapy, androgen deprivation therapy and</i> PCa, with a deadline of 31 March 2022.</p><p><strong>Main results: </strong>These studies showed significant improvements of body composition(Lean body mass MD: 1.12 95% CI [0.48, 1.76], <i>p</i> < 0.01; Body fat rate MD: -1.12 95% CI [-1.99,-0.24], <i>p</i> < 0.05; Appendicular skeletal mass MD: 0.74 95% CI [0.45, 1.03], <i>p</i> < 0.01) and physical function (leg press MD: 77.95 95% CI [38.90, 117.00], <i>p</i> < 0.01; stair climb MD:-0.30 95% CI [-0.49, -0.12], <i>p</i> < 0.01). In addition, the improvement of Body fat mass (MD: -0.21 95% CI [-0.79, 0.37], <i>p</i> > 0.05), 400 m walk (MD: -21.74 95% CI [-45.53, 2.05], <i>p</i> > 0.05) and times up and go (MD: -0.50 95% CI [-1.03, 0.03], <i>p</i> > 0.05) were not obvious. Subgroup analyses showed that RE for ≥ 6 months (compared with RE intervention for < 6 months) and starting exercise immediately after androgen deprivation therapy (ADT) (compared with delayed exercise after ADT) resulted in more significant improvements in body composition. Furthermore, the results showed that the exercise intensity of 8-12 RM significantly improved body composition.</p><p><strong>Conclusions: </strong>RE seems to be a promising approach in order to improve body composition and physical function in PCa patients to offset their treatment-related side effects. RE should be used as a means of rehabilitation and care for PCa. Starting exercise immediately after ADT and extending exercise time while choosing the right intensity can better improve the patients' body composition and function.</p><p><strong>Registration number: </strong>INPLASY202280019.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40466583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID 19 on erectile function.","authors":"D H Adeyemi,&nbsp;A F Odetayo,&nbsp;M A Hamed,&nbsp;R E Akhigbe","doi":"10.1080/13685538.2022.2104833","DOIUrl":"https://doi.org/10.1080/13685538.2022.2104833","url":null,"abstract":"<p><p><b>Purpose:</b> COVID-19, a novel infection, presented with several complications, including socioeconomical and reproductive health challenges such as erectile dysfunction (ED). The present review summarizes the available shreds of evidence on the impact of COVID-19 on ED.<b>Materials and methods:</b> All published peer-reviewed articles from the onset of the COVID-19 outbreak to date, relating to ED, were reviewed. <b>Results:</b> Available pieces of evidence that ED is a consequence of COVID-19 are convincing. COVID-19 and ED share common risk factors such as disruption of vascular integrity, cardiovascular disease (CVD), cytokine storm, diabetes, obesity, and chronic kidney disease (CKD). COVID-19 also induces impaired pulmonary haemodynamics, increased ang II, testicular damage and low serum testosterone, and reduced arginine-dependent NO bioavailability that promotes reactive oxygen species (ROS) generation and endothelial dysfunction, resulting in ED. In addition, COVID-19 triggers psychological/mental stress and suppresses testosterone-dependent dopamine concentration, which contributes to incident ED.<b>Conclusions:</b> In conclusion, COVID-19 exerts a detrimental effect on male reproductive function, including erectile function. This involves a cascade of events from multiple pathways. As the pandemic dwindles, identifying the long-term effects of COVID-19-induced ED, and proffering adequate and effective measures in militating against COVID-19-induced ED remains pertinent.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40599866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: the association between histological prostatitis and benign prostatic hyperplasia: a single-center retrospective study.","authors":"Ye Tian,&nbsp;Xueyuan Zhang,&nbsp;Heng Zhang,&nbsp;Guangheng Luo","doi":"10.1080/13685538.2022.2099829","DOIUrl":"https://doi.org/10.1080/13685538.2022.2099829","url":null,"abstract":"","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40642138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower urinary tract symptoms are associated with clinically relevant depression, anxiety, and stress symptoms.","authors":"Liliana Vartolomei,&nbsp;Andrei Cotruș,&nbsp;Sabin Octavian Tătaru,&nbsp;Mihai Dorin Vartolomei,&nbsp;Adrian Man,&nbsp;Matteo Ferro,&nbsp;Camelia Stanciu,&nbsp;Anca Ileana Sin,&nbsp;Shahrokh F Shariat","doi":"10.1080/13685538.2022.2040981","DOIUrl":"https://doi.org/10.1080/13685538.2022.2040981","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the correlation between lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and testosterone deficiency (TD) with depressive, stress, and anxiety symptoms.</p><p><strong>Material and methods: </strong>From October 2019 to March 2020, 113 males were included. Inclusion criteria: age 40-75, no clinical suspicion of prostate cancer, no serious cardiovascular comorbidities. All patients completed a set of questionnaires: International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF-5), and Depression Anxiety Stress Scales (DASS-21).</p><p><strong>Results: </strong>Median age was 62 years (range 40-74), mean IPSS score was 10.94 (SD 7.75), mean IIEF-5 score 13.12 (SD 7.08), and mean DASS-21 score 11.35 (SD 8.24). According to DASS-21 subscales, 28 (24.8%) patients had depressive symptoms, 25 (22.1%) anxiety symptoms, and 25 (22.1%) stress symptoms. Depression was associated with LUTS (14.5 vs. 8 score, <i>p</i> = .002). Similarly, stress symptoms were associated with LUTS (IPSS 15 vs. 7 score, <i>p</i> = .0001) and with ED (IIEF-5 5 vs. 15 score, <i>p</i> = .01). Positive Spearman's rho correlations between LUTS and all three, depression, anxiety, and stress symptoms were found (<i>p</i> values <.001).</p><p><strong>Conclusions: </strong>LUTS is associated with depression, anxiety, and stress symptoms. Screening for these symptoms could help with individual counseling and management.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39642700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oxidative stress with erectile dysfunction in community-dwelling men and men on dialysis.","authors":"Naoki Fujita,&nbsp;Masaki Momota,&nbsp;Mizuri Ishida,&nbsp;Takuro Iwane,&nbsp;Shingo Hatakeyama,&nbsp;Takahiro Yoneyama,&nbsp;Yasuhiro Hashimoto,&nbsp;Kazuaki Yoshikawa,&nbsp;Kanemitsu Yamaya,&nbsp;Chikara Ohyama","doi":"10.1080/13685538.2022.2103113","DOIUrl":"https://doi.org/10.1080/13685538.2022.2103113","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the association between oxidative stress and erectile dysfunction (ED) in community-dwelling men and men on dialysis.</p><p><strong>Methods: </strong>This cross-sectional study included 398 community-dwelling men and 42 men on dialysis. Oxidative stress was assessed using 8-hydroxy-2'-deoxyguanosine (8-OHdG). Univariable and multivariable logistic regression analyses were performed to evaluate the association between oxidative stress and ED.</p><p><strong>Results: </strong>Spearman's rank correlation test showed no significant correlation between urine 8-OHdG levels and the 5-Item International Index of Erectile Function scores in community-dwelling men (ρ = -0.005, <i>p</i> = 0.917) and between plasma 8-OHdG levels and the Sexual Health Inventory for Men scores in men on dialysis (ρ = 0.166, <i>p</i> = 0.295). In community-dwelling men, univariable and multivariable analyses revealed that urine 8-OHdG level was not significantly associated with ED (odds ratio [OR]: 1.005, 95% confidence interval [CI]: 0.884-1.144, <i>p</i> = 0.934; OR: 0.930, 95% CI: 0.798-1.084, <i>p</i> = 0.353; respectively). In men on dialysis, univariable analyses revealed that plasma 8-OHdG level was not significantly associated with severe ED (OR: 0.967, 95% CI: 0.876-1.066, <i>p</i> = 0.498).</p><p><strong>Conclusions: </strong>Oxidative stress was not significantly associated with ED prevalence and severity in community-dwelling men and men on dialysis.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}