Aging Male最新文献_第10页

The association between body mass index and testosterone deficiency in aging Chinese men with benign prostatic hyperplasia: results from a cross-sectional study. 中国老年男性良性前列腺增生患者体重指数与睾酮缺乏的关系:一项横断面研究的结果

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2019-05-06 DOI: 10.1080/13685538.2019.1604652

Yu Wu, Ding Xu, Hai-Bo Shen, Su-Bo Qian, Jun Qi, Xu-Jun Sheng

{"title":"The association between body mass index and testosterone deficiency in aging Chinese men with benign prostatic hyperplasia: results from a cross-sectional study.","authors":"Yu Wu, Ding Xu, Hai-Bo Shen, Su-Bo Qian, Jun Qi, Xu-Jun Sheng","doi":"10.1080/13685538.2019.1604652","DOIUrl":"https://doi.org/10.1080/13685538.2019.1604652","url":null,"abstract":"Background and objectives: Evidence has supported obesity as a risk factor for both benign prostate hyperplasia (BPH) and hypogonadism. In this paper, we performed a retrospective study and discussed the prevalence of testosterone deficiency (TD) and its relationship to body mass index (BMI) in aging Chinese men with BPH who have surgical intervention.Material and methods: We reviewed the clinical data by age, BMI, medical history, serum prostate-specific antigen (PSA) levels, serum total testosterone (TT) levels, biochemical analysis, and transrectal ultrasound. BMI and other variables were considered to be independent variables in an effort to evaluate any potential associations between these factors and TD status using non-adjusted and multivariate-adjusted regression models.Results: Of the 795 BPH participants, 27.2% (216) patients had TD. After adjusting for all potential covariates, there was a similar J-shaped relationship between BMI and TD, with an inflection point of 19.2 kg/m2. The effect sizes and the confidence intervals on the left and right sides of this inflection point were 0.6 (0.4-1.0) (p = .043) and 1.2 (1.1-1.3) (p < .001), respectively.Conclusion: Nearly one-third of the aging Chinese BPH patients had TD in this study. The association between BMI and TD is not simple. A J-shaped curve correlation was detected. BMI was positively correlated with TD when it was over 19.2 kg/m2 and inversely correlated with TD when it was below 19.2 kg/m2. Long-term prospective studies are needed to confirm these findings.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"841-846"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1604652","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37391169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

In vitro contractile responses of human detrusor smooth muscle to oxytocin: does it really have effect? 人类逼尿肌平滑肌对催产素的体外收缩反应:它真的有效果吗?

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2020-01-08 DOI: 10.1080/13685538.2020.1711722

Fatih Tarhan, Nesrin Çağlayan Duman, Songül Özkula, Atila Karaalp, Önder Cangüven

{"title":"In vitro contractile responses of human detrusor smooth muscle to oxytocin: does it really have effect?","authors":"Fatih Tarhan, Nesrin Çağlayan Duman, Songül Özkula, Atila Karaalp, Önder Cangüven","doi":"10.1080/13685538.2020.1711722","DOIUrl":"https://doi.org/10.1080/13685538.2020.1711722","url":null,"abstract":"Background and objectives: The aim of this study was to investigate the contractile effects of oxytocin (OT) in human detrusor muscle in in vitro conditions.Material and methods: Human detrusor muscle samples were obtained from seven patients that undergone radical cystectomy. Four female Wistar rats' uterine samples were used as control. Contractile responses were tested of carbachol in organ bath. Cumulative concentration response curves were constructed to OT and then the strips were incubated with atosiban (OT antagonist) and a second concentration response curve to OT were constructed.Results: Carbachol, contracted all human strips for the functionality test whereas OT in any concentrations did not produce significant contraction on all human strips. In only one bladder strip and in a very high concentration slight contraction was recorded. Moreover no contractile response was recorded in any OT concentrations in the presence of atosiban. The rat uterine strips responded to OT in a dose dependent manner. Atosiban, the OT receptor antagonist diminished totally those contractile responses.Conclusion: It is been demonstrated here that there is no contractile response to OT in human detrusor muscle. These findings should be supported by further investigations determining the presence of the OT receptor in human detrusor.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1141-1145"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1711722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37520620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Carotid Doppler ultrasonographic findings of dapagliflozin use in type 2 diabetic patients. 达格列净用于2型糖尿病患者的颈动脉多普勒超声表现。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2020-04-28 DOI: 10.1080/13685538.2020.1758657

Attila Onmez, Feyzi Gokosmanoglu, Gulsah Baycelebi, Ali Ahmet Arıkan

{"title":"Carotid Doppler ultrasonographic findings of dapagliflozin use in type 2 diabetic patients.","authors":"Attila Onmez, Feyzi Gokosmanoglu, Gulsah Baycelebi, Ali Ahmet Arıkan","doi":"10.1080/13685538.2020.1758657","DOIUrl":"https://doi.org/10.1080/13685538.2020.1758657","url":null,"abstract":"Aim: Sodium-glucose cotransporter 2 inhibitors have been shown to reduce the risk of cardiovascular disease in type 2 diabetes (T2DM) patients. The purpose of this study was to evaluate cardiovascular disease risk indirectly through Doppler ultrasonography (USG) of carotid artery vascular markers in T2DM patients using dapagliflozin.Methods: One hundred forty-five patients presenting to our clinic between March 2016 and June 2018 and diagnosed with T2DM were included in the study. These were divided into two groups - a dapagliflozin group of 85 patients and a 60-member non-dapagliflozin control group. Common carotid artery end-diastolic velocity (EDV), peak systolic velocity (PSV), and resistive index (RI) parameters were evaluated using Doppler USG in both groups.Results: The mean duration of follow-up was 2.2 ± 0.4 years. Mean ages were 45 ± 14 years in the dapagliflozin group and 42 ± 15 in the control group. Mean HbA1c was 7.4 ± 1.6 in the dapagliflozin group and 7.3 ± 2.1 in the control group. Common carotid artery, PSV, and EDV parameters were higher (p = .012/p = .036), while RI was lower (p ˂ .001), in the dapagliflozin group than in the control group.Conclusion: Vascular resistance was lower in the group using dapagliflozin for diabetes management.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1246-1250"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1758657","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37879323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Predictive value of perfusion index for mortality in mechanically ventilated patients. 灌注指数对机械通气患者死亡率的预测价值。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2020-05-06 DOI: 10.1080/13685538.2020.1760816

Mehmet Can Er, Cengiz Kaya, Yasemin Burcu Ustun, Ali Haydar Sahinoglu

{"title":"Predictive value of perfusion index for mortality in mechanically ventilated patients.","authors":"Mehmet Can Er, Cengiz Kaya, Yasemin Burcu Ustun, Ali Haydar Sahinoglu","doi":"10.1080/13685538.2020.1760816","DOIUrl":"https://doi.org/10.1080/13685538.2020.1760816","url":null,"abstract":"Aim: This study aimed to examine the prognostic significance of the perfusion index (PI) in mechanically ventilated patients.Methods: Study included sixty patients who had the risk factors for the development of acute respiratory distress syndrome and received mechanical ventilator (MV) support in intensive care unit (ICU) unit between January 2017/January 2018. The demographic characteristics, vital signs, blood gas parameters, lactate levels, prognostic scores, and use of inotropic drugs were recorded. Arterial blood gas and PI measurements at the frontal region were performed at the time of and 12th and 24th hours of admission to the ICU. The patients were followed up for 60 days, and the outcome was recorded.Results: Twelve patients (20%) died during the first 7 days, and 27 patients (45%) died within 60 days of the admission. Multivariate analyses to determine potential predictors of 7 and 30-day mortality showed that only 24th-hour lactate level was independent predictor of 60-day mortality, and the PI at 24th was the sole independent predictor of 7-day mortality.Conclusion: The PI did not predict 60-day mortality in MV patients who had risk factors for the development of Acute Respiratory Distress Syndrome (ARDS). However, the PI at 24th may be a significant predictor of 7-day mortality.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1251-1258"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1760816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37905507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Can transurethral thermotherapy save elderly patients with benign prostatic obstruction and high ASA score? 经尿道热疗能拯救ASA评分较高的老年良性前列腺梗阻患者吗?

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2020-05-13 DOI: 10.1080/13685538.2020.1765329

Erdal Benli, Ahmet Yuce, Ismail Nalbant, Abdullah Cirakoglu, Ibrahim Yazici

{"title":"Can transurethral thermotherapy save elderly patients with benign prostatic obstruction and high ASA score?","authors":"Erdal Benli, Ahmet Yuce, Ismail Nalbant, Abdullah Cirakoglu, Ibrahim Yazici","doi":"10.1080/13685538.2020.1765329","DOIUrl":"https://doi.org/10.1080/13685538.2020.1765329","url":null,"abstract":"Introduction: The Aim of this study was to investigate the efficacy of the new bipolar radiofrequency prostate thermotherapy method for those with high potential surgical risk and also for patients with a chronic catheter.Material and methods: 103 patients attending our clinic due to BPO and related complaints with high ASA score had outcomes after the procedure recorded prospectively and investigated retrospectively. Qmax, prostate volume, IPSS score, quality of life score, and presence of catheters were recorded before the procedure and analyzed with the outcomes after the procedure.Results: The ASA scores were calculated as 3.0 ± 1.0 (IQR). Before the procedure, Qmax values (mean (SD)) were 5.11 ± 5.37 ml/s, while in the 6th month after the procedure Qmax values were identified as 10.45 ± 3.8 ml/s (p < 0.001). Of 53 patients (55.2%) with chronic catheters who could not be operated, 30 (61.2%) no longer required urinary catheter.Conclusion: Bipolar RF thermotherapy appears to be an effective method for patients with BPO who cannot be operated. Due to the surgical risks of patients dependent on the catheter in spite of receiving medical treatment, it is a good alternative to remove catheter dependence. It may be one of the methods that should be remembered, especially in this patient group.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1316-1320"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1765329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37930402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Assessing the impact of sexual function on perceptions of masculinity among prostate cancer survivors in the United States: findings from the prostate cancer registry. 评估性功能对美国前列腺癌幸存者男性气概认知的影响:来自前列腺癌登记的发现。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2018-11-20 DOI: 10.1080/13685538.2018.1535582

Antoine B Richards, Kimberly Davis, Reginald O Gooden

{"title":"Assessing the impact of sexual function on perceptions of masculinity among prostate cancer survivors in the United States: findings from the prostate cancer registry.","authors":"Antoine B Richards, Kimberly Davis, Reginald O Gooden","doi":"10.1080/13685538.2018.1535582","DOIUrl":"https://doi.org/10.1080/13685538.2018.1535582","url":null,"abstract":"Background: Prostate cancer carries emasculating symptoms and treatment effects. These symptoms and treatment effects impact a man's sexual function; a central-theme to masculinity. This study seeks to assess the impact of sexual function on perceptions of masculinity.Methods: A voluntary-sample of men self-selected into the registry. Data were based on a series of questions related to Health-Related Quality of Life and functional status.Results: Based on the analysis, 50.2% of men did not feel less masculine, 33.2% of men were still interested in sex, 40.2% of men still engaged in sex \"a little bit,\" and 34.8% of men still found sex \"quite a bit\" enjoyable. Additionally, 31.1% of identified issues with erectile dysfunction and 45.5% of men showed no discomfort with being sexually active.Conclusion: Sexual function has an impact on perceptions of masculinity but additional underlying issues outside of sexual function may contribute to perceptions of masculinity.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"496-500"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1535582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36700737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The severity of hypogonadism symptoms and its risk factors among male employees of Tehran University of Medical Sciences. 德黑兰医科大学男性雇员性腺功能减退症状的严重程度及其危险因素

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2019-01-16 DOI: 10.1080/13685538.2018.1534095

Elahe Afsharnia, Minoo Pakgohar, Hamid Haghani, Asma Sarani, Shahla Khosravi

{"title":"The severity of hypogonadism symptoms and its risk factors among male employees of Tehran University of Medical Sciences.","authors":"Elahe Afsharnia, Minoo Pakgohar, Hamid Haghani, Asma Sarani, Shahla Khosravi","doi":"10.1080/13685538.2018.1534095","DOIUrl":"https://doi.org/10.1080/13685538.2018.1534095","url":null,"abstract":"Objectives: The current study was conducted to examine the severity of hypogonadism symptoms and their risk factors among the male employees of Tehran University of Medical Sciences (TUMS).Methods: This cross-sectional study was conducted on 80 male employees aged 40-60 years, with hypogonadism, at TUMS. The participants were selected through census sampling. The data collection tools included the demographic questionnaire and the Aging Male Symptoms (AMS) questionnaire. The participants first completed the demographic questionnaire and then the AMS questionnaire. SPSS statistical software version 22 (Chicago, IL) was used to analyze the data, and one-way ANOVA tests, Pearson's correlation coefficient, and stepwise multivariate logistic regression were applied.Results: Based on our findings, the mean overall score of hypogonadism symptoms was 41.71 ± 9.20. Based on Pearson's correlation coefficient results, there was a statistically significant association between the severity of hypogonadism symptoms and age (p < .001). Furthermore, there were significant associations between the economic status, cigarette consumption and hours of sleep and the severity of hypogonadism symptoms (p < .001).Conclusions: The current study's results showed that certain factors can affect hypogonadism in males. Thus, it is important to reduce the severity of hypogonadism symptoms and to modify the factors related to this phenomenon.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"489-495"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1534095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36913409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Life quality change after inflatable penile prosthesis implantation. 充气阴茎假体植入术后生活质量的变化。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2018-06-27 DOI: 10.1080/13685538.2018.1487393

Iyimser Ure, Ata Ozen, Cavit Can

{"title":"Life quality change after inflatable penile prosthesis implantation.","authors":"Iyimser Ure, Ata Ozen, Cavit Can","doi":"10.1080/13685538.2018.1487393","DOIUrl":"https://doi.org/10.1080/13685538.2018.1487393","url":null,"abstract":"Purpose: It was aimed to evaluate the changes in quality of life in patients with erectile dysfunction (ED) after inflatable penile prosthesis implantation.Material and methods: Forty-one patients who underwent to an inflatable penile prosthesis implantation surgery due to ED were included in the study. The age of the patients, the indications for surgery, and the type of prosthesis implanted were recorded. All patients were implanted two-piece inflatable (AMS Ambicor™) or three-piece inflatable (AMS 700™) prostheses. A 36-item short form (SF-36) was used to assess the life quality of patients. The scores obtained from these forms were recorded and used to compare the preoperative and postoperative quality of life of the patients.Results: The mean age of the patients was 59.9 (38-78) years. The mean follow-up was 25.1 (12-39) months. A three-piece inflatable penile prosthesis was implanted in 11 (26.8%) of the 41 patients and the others were implanted with a two-piece inflatable penile prosthesis. Average SF-36 scores were increased significantly after surgery in all groups.Conclusions: Inflatable penile prosthesis implantation is one of the most satisfactory treatment methods of ED and our study shows that with this treatment the patients can be provided a significant improvement in life quality.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"362-368"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1487393","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36264218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of senescence on morphological, functional and oxidative features of fresh and cryopreserved canine sperm. 衰老对新鲜和冷冻犬精子形态、功能和氧化特性的影响。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2018-07-11 DOI: 10.1080/13685538.2018.1487931

Maíra Morales Brito, Daniel de Souza Ramos Angrimani, Bruno Rogério Rui, Giulia Kiyomi Vechiato Kawai, João Diego Agostini Losano, Camila Infantosi Vannucchi

{"title":"Effect of senescence on morphological, functional and oxidative features of fresh and cryopreserved canine sperm.","authors":"Maíra Morales Brito, Daniel de Souza Ramos Angrimani, Bruno Rogério Rui, Giulia Kiyomi Vechiato Kawai, João Diego Agostini Losano, Camila Infantosi Vannucchi","doi":"10.1080/13685538.2018.1487931","DOIUrl":"https://doi.org/10.1080/13685538.2018.1487931","url":null,"abstract":"The present research aimed to compare the hormonal profile, sperm quality and freezability of young and senile dogs. Dogs were assigned into Young Group (n = 11) and Senile Group (n = 11), additionally divided into Fresh Semen Group and Cryopreserved Semen Group. Males were evaluated for libido score and blood estrogen and testosterone assay. Sperm morphofunctional evaluations were performed based on Computer Assisted Sperm Analysis, morphology, mitochondrial activity, mitochondrial membrane potential, plasma and acrosomal membrane integrity, and DNA fragmentation. Sperm oxidative features were: protein oxidation, lipid peroxidation and production of advanced glycation end-products. Young dogs had higher libido score, sperm velocity average pathway, linearity of motility and mitochondrial activity index and lower percentage of major defects, total defects and proximal cytoplasmic droplet, despite the lack of difference between hormone profile of aged dogs. Fresh semen of senile dogs had increased percentage of spermatozoa with high mitochondrial membrane potential compared to young dogs and to cryopreserved sperm. Cryopreserved semen of young dogs had higher acrosomal membrane integrity compared to the Senile Group. In conclusion, sperm of aged dogs have reduced quality, signaled by higher morphological defects, ultimately altering sperm mitochondrial function and sperm kinetics. Furthermore, spermatozoa from senile dogs are more sensible to cryoinjury.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 4","pages":"279-286"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1487931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36301219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

A randomized, controlled study of treatment with ojayeonjonghwan for patients with late onset hypogonadism. ojayeonjonghwan治疗迟发性性腺功能减退的随机对照研究。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2018-07-24 DOI: 10.1080/13685538.2018.1480599

Kyu Won Lee, Sang Rak Bae, Hyun Cheol Jeong, Jin Bong Choi, Sae Woong Choi, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Sae Woong Kim

{"title":"A randomized, controlled study of treatment with ojayeonjonghwan for patients with late onset hypogonadism.","authors":"Kyu Won Lee, Sang Rak Bae, Hyun Cheol Jeong, Jin Bong Choi, Sae Woong Choi, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Sae Woong Kim","doi":"10.1080/13685538.2018.1480599","DOIUrl":"https://doi.org/10.1080/13685538.2018.1480599","url":null,"abstract":"Objectives: We investigate the effects of Ojayeonjonghwan (KH-204) in men with late-onset hypogonadism (LOH) symptoms.Material and methods: Initial PSA, testosterone, lipid profile and questionnaires about LOH-related symptoms were checked. After 8 weeks of the treatment (control or KH-204), questionnaires and serological tests were repeated to evaluate the efficacy of the agent. The changes of variables in each group and the difference between two groups were compared.Results: A total of 78 men were enrolled, and randomly assigned to the control group (n = 39) or KH-204 group (n = 39). Baseline characteristics of both group are comparable. AMS total score of control and KH-204 group were both improved at 8 weeks (p = .010, <.001), and there was a statistically significant difference between the two groups (favorable in KH-204 group, p = .006). At 8 weeks, total IIEF score of control and KH-204 group were both improved, and there was no statistically significant difference in the degree of improvement between the two groups (p = .303). There was no statistically significant difference of laboratory findings, in intra-group changes and inter-group comparisons.Conclusions: KH-204 was found to be effective in all LOH symptoms without changing of laboratory results. KH-204 may be safely used for treatment of male with LOH-related symptoms.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 4","pages":"264-271"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1480599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36339877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6