Aging Male最新文献

{"title":"Internal carotid artery anomaly in oropharynx as a rare cause of sore throat.","authors":"Amira Nasser Al Hail,&nbsp;Nasfareen Zada,&nbsp;Ahmad Al-Juboori,&nbsp;Asharaf Ayinikunnan","doi":"10.1080/13685538.2020.1800630","DOIUrl":"https://doi.org/10.1080/13685538.2020.1800630","url":null,"abstract":"<p><strong>Background: </strong>Anomaly of internal carotid artery (ICA) is a very rare variation. In almost all the cases, the anomaly was on the right side. This right-sided predominance may be attributed to anatomical influences and factors affecting blood pressure.</p><p><strong>Case report: </strong>A 67-years-old man presented to ear, nose and throat (ENT) outpatient clinic in Al Wakra Hospital complain of sore throat, there was associated medical co-morbidities (diabetic, hypertensive, hyperlipidemia and coronary artery diseases). ENT examination showed a pulsating, bulging mass on the right posterolateral oropharyngeal wall with normal mucosal covering. CT scan with contrast showed aberrant course of the right ICA which is coursing medially in prevertebral space and right posterolateral hypopharyngeal wall over a length of approximately 1.7 cm, making an acute U-turn before resuming the normal course and its distal aspects, only a thin layer of mucosa noted over the aberrant course of ICA.</p><p><strong>Conclusion: </strong>Anomaly of ICA must be kept in mind in the evaluation of patients with sore throat associated with oropharyngeal mass especially in old-aged patients with atherosclerotic diseases.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1467-1470"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1800630","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38308534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the clinical efficacy of simultaneous transurethral resection of both bladder cancer and the prostate: a systematic review and meta-analysis.","authors":"Li Zhou,&nbsp;Xinglong Liang,&nbsp;Kaizhong Zhang","doi":"10.1080/13685538.2020.1718637","DOIUrl":"https://doi.org/10.1080/13685538.2020.1718637","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to examine the clinical efficacy of simultaneous transurethral resection of bladder cancer and the prostate (TURBT + TURP) in non-muscle invasive bladder cancer (NMIBC) and benign prostatic hyperplasia (BPH) patients.</p><p><strong>Method: </strong>We conducted systematic research in PubMed, EMBASE, and Cochrane Library databases to identify retrospective studies and prospective randomized controlled trials (RCTs) comparing patient outcomes between TURBT + TURP and TURBT-only patients. The meta-analysis was conducted using Review Manager 5.3.</p><p><strong>Results: </strong>We identified eight relevant studies involving a total of 1032 patients. We found that patients that underwent TURBT + TURP exhibited significantly lower recurrence rates [odds ratio (OR), 0.70; 95% confidence interval (CI), 0.53-0.93; <i>p</i> = .01] and increased maximal urinary flow rate (Qmax) (WMD, 5.92; 95% CI, 4.67-7.16; <i>p</i> < .001) compared with patients that underwent TURBT-only. However, rates of recurrence at the prostatic urethra/bladder neck and bladder tumor progression, as well as the time to recurrence did not differ significantly between these two groups.</p><p><strong>Conclusions: </strong>Simultaneous TURBT + TURP can be safely performed in patients with NMIBC and BPH and improves patient quality of life, without any risk of increasing tumor recurrence or metastasis rates. Comprehensive RCTs are needed to confirm the results of this study.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1182-1193"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1718637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37611999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years.","authors":"Mingquan Chen,&nbsp;Xiong Chen,&nbsp;Yuanqing Dai,&nbsp;Zhiming Yang,&nbsp;Xiaobo Zhang,&nbsp;Dongjie Li","doi":"10.1080/13685538.2019.1607284","DOIUrl":"https://doi.org/10.1080/13685538.2019.1607284","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the safety and efficacy of wide local excision combined with aminolevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of scrotal Paget's disease in patients of advanced age.</p><p><strong>Methods: </strong>Data were collected for 16 patients (mean age, 68.44 years) with scrotal Paget's disease treated with wide local excision combined with ALA PDT and followed up from June 2014 to February 2018. Pathological examination after wide local excision confirmed Paget's disease. The patients underwent three courses of ALA PDT postoperatively and were followed up to determine the curative effect and complications in the short and middle term.</p><p><strong>Results: </strong>The disease duration ranged from 4 to 76 months (mean, 36 months). Ten patients underwent simple excision, six underwent skin flap transfer, and two required reoperations due to skin flap necrosis and infection. The patients were followed up for 3 to 42 months after ALA PDT, during which time two patients developed metastasis (recurrence rate, 12.50%). No other serious complications occurred during follow-up except for lower limb movement disorder in one patient (6.25%).</p><p><strong>Conclusions: </strong>Wide local excision combined with ALA PDT shows good clinical efficacy and a low complication rate in patients of advanced age with scrotal Paget's disease.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"854-859"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1607284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37370241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma thiols in prostate cancer.","authors":"Suleyman Sahin,&nbsp;Fatih Karataş","doi":"10.1080/13685538.2019.1631273","DOIUrl":"https://doi.org/10.1080/13685538.2019.1631273","url":null,"abstract":"Sir, We greatly appreciated one of the recently published article entitled Does plasma thiol and disulphide be a new marker for prostate cancer in prostate-specific antigen level between 10 and 20ng/mL by Topaktas et al. in your journal. The authors performed a prospective study investigating the plasma total thiol (TT), native thiol (NT), and disulfide (SS) levels as potential new biomarkers for the diagnosis of prostate cancer (PC), combining serum TT, NT, and SS levels with serum PSA measurements in 76 participants with elevated PSA levels ranging 0–20ng/mL, and further concluding that serum TT levels may help guide detecting PC, particularly with PSA levels between 10 and 20ng/ml [1]. However, we would like to kindly challenge some of the findings of the study as there seems to be confusing and conflicting parts as indicated below. As previously and generally shown in the literature, serum TT, NT, and SS levels were found to be significantly low in benign proliferative pathologies and cancer disease compared to healthy subjects and also shown to be independent predictors of poor survival [2,3]. In the present study, the authors found serum TT, NT, and SS levels higher in Group 1 than those of Group 2, with no significant difference. However, in the discussion part, they reported the following conclusion; “although not statistically significant, when PSA levels were between 10 and 20 (group 2), serum TT and NT levels were found to be high” as indicated by their own words in the manuscript. The results and conclusion appear to be discordant, hence having a likelihood of a huge confounder. How do the authors explain these inconsistent findings? One another important finding needs to be clarified is that authors have mentioned from a recent study [4] investigating the role of thiol/disulfide homeostasis in the differentiation of benign diseases from PC, which concluded that serum TT and NT levels were significantly higher in patients with PC than those found in patients with benign diseases. Of course, the literature can include various results; however, in order to support their results, the authors have cited another paper [5], which evaluated thiol/disulfide homeostasis prior to and 6months following radical prostatectomy in PC patients reporting that decreased TT and total antioxidant status levels weakened anti-oxidant defense mechanism in patients with PC, and further concluding that increased oxidative stress in PC patients may have a role in the etiopathogenesis of PC. However, the results of the two studies mentioned in the manuscript oppose to each other, hence need to be clarified. There are deficiencies in terms of Material – Method. The authors did not specify whether serum samples were obtained immediately by centrifugation and the Celcius degree to which they were stored. Moreover, another important point is that the researchers did not state whether they stored serum samples for the same period on average, according to the PSA gro","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"914"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1631273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37376977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between serum thyroid hormone levels and hand grip among elderly male Chinese inpatients.","authors":"Lingyan Chen,&nbsp;Yu Hu","doi":"10.1080/13685538.2019.1634044","DOIUrl":"https://doi.org/10.1080/13685538.2019.1634044","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid dysfunction is closely associated with skeletal muscle weakness. However, data on the optimal serum range of thyroid hormones for maintaining muscle strength in the elderly is lacking.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis in male elderly inpatients from the Geriatric Department of Zhongshan Hospital (affiliated to Fudan University, Shanghai, China). Serum biochemical parameters and thyroid hormones were detected for each participant. Hand grip (HG) was measured, with low hand grip defined as HG <26 kg according to the standard of the Asian Working Group for Sarcopenia. Logistic regression was used to evaluate the effects of different serum thyroid hormone levels on HG.</p><p><strong>Results: </strong>The majority of the subjects were euthyroid. The prevalence of low hand grip was 48.5%. Stratified by the free thyroxine (FT4) quartiles, the results showed HG was the highest in the third quartile. Multiple logistic regression analysis showed that compared with those in the first quartile, subjects in the third quartile of FT4 had a significantly lower risk of low hand grip (OR = 0.133, 95%CI: 0.020-0.610, <i>p</i> = .009), after adjusting potential confounding factors.</p><p><strong>Conclusion: </strong>In elderly male inpatients, maintaining a narrower serum range of thyroid hormone might be needed to protect skeletal muscle strength.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"928-933"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1634044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37385526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins are effective in the treatment of benign prostatic hyperplasia with metabolic syndrome.","authors":"Suleyman Sami Cakir,&nbsp;Levent Ozcan,&nbsp;Emre Can Polat,&nbsp;Huseyin Besiroglu,&nbsp;Ramazan Kocaaslan,&nbsp;Alper Ötunctemur,&nbsp;Emin Ozbek","doi":"10.1080/13685538.2018.1541979","DOIUrl":"https://doi.org/10.1080/13685538.2018.1541979","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of statins and ɑ blockers drug therapies for benign prostatic hyperplasia (BPH) in patients with metabolic syndrome (MetS).</p><p><strong>Materials and method: </strong>A total of three hundred patients were randomly distributed into three groups of one hundred patients each. Group 1 received only ɑ-adrenoceptor antagonist (ɑ-blocker, AB) (Tamsulosin), group 2 received only statin (atorvastatin), and group 3 received AB plus statin (Tamsulosin + Atorvastatin). The efficacy measurement was assessed by analyzing the changes from baseline in the total International Prostate Symptom Score (IPSS), disease-specific QoL question score and maximum urinary flow rate at the end of 6 months in each group and between the three groups.</p><p><strong>Results: </strong>Pre-treatment and post-treatment value of triglycerides (TG), high-density lipoprotein (HDL), and prostate volüme (PV) were not significantly different in AB group, while TG and PV were significantly lower in patients taking statin and combined therapy. The significant decrease was demonstrated in maximum urinary flow rate (<i>Q</i>_max) in three groups. However, the most significant decrease was observed in the combination therapy group. IPSS, postvoid residual urine volüme (PVR), and Quality of Life score (QoL) significantly changed in three groups.</p><p><strong>Conclusion: </strong>We recommend of the use of statins in those men with BPH accompanied by MetS in which AB is ineffective alone.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"538-543"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1541979","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36754879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio predictive for lamina propria invasion in aging patients?","authors":"Yavuz Tarik Atik,&nbsp;Haci Ibrahim Cimen,&nbsp;Deniz Gul,&nbsp;Safa Arslan,&nbsp;Osman Kose,&nbsp;Fikret Halis","doi":"10.1080/13685538.2020.1847068","DOIUrl":"https://doi.org/10.1080/13685538.2020.1847068","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate if the preoperative neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are predictive in discriminating between Ta and T1 tumors in aging male patients.</p><p><strong>Methods: </strong>We retrospectively evaluated 240 male patient data who were ≥ 65 years old, diagnosed primary non-muscle invasive bladder cancer (NMIBC) with transurethral resection between 2008 and 2020. The patients were divided into the two groups according to the pathological stage, which has a stage of Ta defined group 1 and stage of T1 defined group 2. Before the transurethral resection, serum levels of NLR and PLR were obtained from each patient and compared between the groups.</p><p><strong>Results: </strong>About 115 patients enrolled in group 1 (pTa patients) and 106 patients enrolled in group 2 (pT1 patients). The median age was 73 years (range 65-89) in group 1 and 75 years (range 65-98) in group 2. In complete blood cell (CBC) parameters, neutrophil count, NLR and PLR were higher and lymphocyte count was lower in group 2. There was no statistical difference in leukocyte and platelet counts between groups.</p><p><strong>Conclusion: </strong>The present study revealed that higher preoperative NLR and PLR were associated with lamina propria invasion in aging male patients with BC and the results have predictive value.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1528-1532"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1847068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38598969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic nephrectomy for giant benign renal schwannoma: a case report and review of literature.","authors":"Chao Wang,&nbsp;Wuyue Gao,&nbsp;Sun Wei,&nbsp;Wu Ligao,&nbsp;Liu Beibei,&nbsp;Liu Jianmin,&nbsp;Yang Xiaohuai,&nbsp;Guo Yuanyuan","doi":"10.1080/13685538.2020.1812566","DOIUrl":"https://doi.org/10.1080/13685538.2020.1812566","url":null,"abstract":"<p><p>Benign giant renal schwannoma is rarely found and the diagnosis difficulty only depends on physical and imagological examination. Pathological examination is essential to confirm the diagnosis of renal schwannoma. Nephrectomy and tumorectomy are primary treatments for renal schwannoma. Although most of the reported patients present satisfactory outcome, however, there is still not sufficient evidence to reveal the biological characteristics and post-operation recurrence rate of renal schwannoma. Herein, we report a rare case of giant and complicated renal schwannoma. A 56-years-old female patient was admitted to the urology department due to left lower back pain for approximately 5 days. No positive signs and other special abnormalities were found. CT scan presented a soft tissue tumor with inhomogeneous enhanced in the renal hilum. Surgery was performed to excise the tumor and left renal. Renal schwannoma was confirmed by pathological examination. At the 6-month follow-up, no evidence of recurrence was found. Our present report could provide more material for further study.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1504-1508"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1812566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38660134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitude towards sexuality and sexual behaviors among men with heart rhythm disorders.","authors":"Rafal Mlynarski,&nbsp;Agnieszka Mlynarska,&nbsp;Krzysztof S Golba","doi":"10.1080/13685538.2019.1592152","DOIUrl":"https://doi.org/10.1080/13685538.2019.1592152","url":null,"abstract":"<p><strong>Aim: </strong>Symptoms of cardiac arrhythmias and the perception of the implantation of a cardiac pacemaker can negatively affect mental health including sexuality and sexual behaviors. The aim of this study was to assess the attitude towards sexuality and sexual behaviors among men with cardiac arrhythmias.</p><p><strong>Methods: </strong>The study included 80 men (aged 58.6 ± 9.23 years) with heart rhythm disorders who had qualified for cardiac pacemaker implantation. The International Index of Erectile Function IIEF-15 was completed at least one day before cardiac pacemaker implantation by all of the patients.</p><p><strong>Results: </strong>The average results of the IIEF for all of the included patients was 41.87 ± 7.57 and were statistically worse in the population with atrioventricular blocks (39.60 ± 7.79) compared to those with sinus node dysfunction (44.15 ± 6.71) (<i>p</i> = .0110). The same relationships were found in the subcategory of orgasmic function (<i>p</i> = .0108) as well as intercourse satisfaction (<i>p</i> = .0111). Erectile dysfunction occurred in 88.75% of the patients with diagnosed arrhythmias. There was no statistically significant difference between the occurrence of erectile dysfunction in patients with sinus node dysfunction (87.5%) compared to patients with atrioventricular blocks (90%); <i>p</i> = .7236.</p><p><strong>Conclusion: </strong>We demonstrated that sexuality and sexual behaviors among men with cardiac arrhythmias was found to be statistically worse in the population with atrioventricular blocks compared to those with sinus node dysfunction. It was especially marked in the area of orgasmic function as well as for intercourse satisfaction.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"764-769"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1592152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37263893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the association between grip strength and testosterone.","authors":"Hao-Tse Chiu,&nbsp;Mu-Tsun Shih,&nbsp;Wei-Liang Chen","doi":"10.1080/13685538.2019.1632282","DOIUrl":"https://doi.org/10.1080/13685538.2019.1632282","url":null,"abstract":"<p><strong>Background: </strong>Skeletal muscle is an important site for storing proteins and providing general physical function. Recent research has shown that muscle strength decreases earlier than muscle mass decreases, as shown during the aging process. Our article aimed to compare the association between testosterone levels and grip strength to provide an earlier biomarker to detect muscle weakness.</p><p><strong>Method: </strong>We adopted quartile-based analysis by dividing handgrip power into quartiles, with all participants in the lowest quartile serving as the reference group. Linear regression analysis was conducted between handgrip power and testosterone. Logistic regression models were used to analyze the longitudinal correlation between testosterone levels and the presence of low muscle strength.</p><p><strong>Results: </strong>Serum testosterone levels had a significant correlation with grip strength in all models (<i>p</i> < .001). In addition, high testosterone levels were negatively associated with low muscle strength in all groups (<i>p</i> < .001). A stronger relationship was observed between testosterone levels and grip strength among non-obese participants than among obese participants.</p><p><strong>Conclusions: </strong>In conclusion, our study highlighted that testosterone levels are related to greater grip strength.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"915-922"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1632282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37386074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}