Aging Male最新文献

{"title":"Comparing clinical parameters of abnormal and normal fasting blood glucose in benign prostatic hyperplasia patients.","authors":"Ming-Juan Zhao,&nbsp;Qiao Huang,&nbsp;Xing-Huan Wang,&nbsp;Xuan-Yi Ren,&nbsp;Ying-Hui Jin,&nbsp;Xian-Tao Zeng","doi":"10.1080/13685538.2019.1570493","DOIUrl":"https://doi.org/10.1080/13685538.2019.1570493","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation of clinical measurements on normal and abnormal fasting blood glucose (FBG) with benign prostatic hyperplasia (BPH).</p><p><strong>Methods: </strong>From September 2016 to January 2018, 771 BPH patients were enrolled for further selection. The eligible patients were divided into normal FBG, impaired fasting glucose (IFG), and high risk of type 2 diabetes mellitus (HR-T2DM) groups. Then, relevant parameters were compared among these three groups using Pearson's correlation coefficient.</p><p><strong>Results: </strong>Finally including 443 patients with normal FBG, 113 with IFG and 56 with HR-T2DM. Height, weight, body mass index, smoking status, hemoglobin, serum Na⁺, serum Cl^-, and serum Ca²⁺ were significantly different between normal and abnormal FBG groups. In IFG/HR-T2DM group, obviously connections were demonstrated for weight with prostate volume (PV), for serum Na⁺, PV, and serum Cl^- with total prostate-specific antigen (t-PSA), for FBG with international prostate symptom score (IPSS). In normal FBG group, significant correlations of age, weight, body mass index, hemoglobin, and serum Ca²⁺ with PV, of age, systolic blood pressure, PV, and serum Cl^- with t-PSA; and of FBG, hemoglobin, and serum Na⁺ with IPSS were also observed.</p><p><strong>Conclusions: </strong>Our study suggests that FBG level probably plays an important role in BPH.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"655-662"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1570493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36948395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The depressive effects of androgen deprivation therapy in locally advanced or metastatic prostate cancer: a comparative study.","authors":"Yasin Ceylan,&nbsp;Bulent Gunlusoy,&nbsp;Asli Koskderelioglu,&nbsp;Muhtesem Gedizlioglu,&nbsp;Tansu Degirmenci","doi":"10.1080/13685538.2019.1586869","DOIUrl":"https://doi.org/10.1080/13685538.2019.1586869","url":null,"abstract":"<p><strong>Aim: </strong>To investigate association of androgen deprivation therapy (ADT) with depression and the effect of depression on cognitive functions in men with locally advanced or metastatic prostate cancer.</p><p><strong>Methods: </strong>A total of 144 patients were evaluated in a prospective, comparative study. Group1 consisted of 72 patients with locally advanced or metastatic prostate cancer who received complete ADT treatment continuously for 12 months and group2 (control group) consisted of 72 patients who underwent radical prostatectomy without any additional treatment. MoCA (The Montreal Cognitive Assessment) and HAM-D (Hamilton depression rating scale) tests were used to assess the effects of ADT on depression and cognitive functions.</p><p><strong>Results: </strong>According to post-treatment results of MoCA test, patients had lower mean total scores in both the groups. The deficits were especially prominent in the areas of language ability and short-term memory capacity. In the comparison of two groups according to HAM-D tests, the scores were significantly higher in group1 at baseline-6 month, at baseline-12 month and at 6-12 month follow-up period (<i>p</i> = .003, <i>p</i> < .001, <i>p</i> = .023).There was a relationship between depression and deterioration of language and memory functions at 6th (<i>p</i> < .001, <i>p</i> = .002) and 12th months (<i>p</i> < .001, <i>p</i> = .046). Attention function was deteriorated in these patients at 6th (<i>p</i> < .001) and 12th months (<i>p</i> < .001).</p><p><strong>Conclusions: </strong>ADT causes increase in depression and the deterioration of cognitive functions. ADT should be given carefully to these older group of patients with concomitant morbidities.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"733-739"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1586869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37101709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Andropause symptoms and sickness absence in Japanese male workers: a prospective study.","authors":"Kumi Hirokawa,&nbsp;Yasuhito Fujii,&nbsp;Toshiyo Taniguchi,&nbsp;Jiro Takaki,&nbsp;Akizumi Tsutsumi","doi":"10.1080/13685538.2020.1862078","DOIUrl":"https://doi.org/10.1080/13685538.2020.1862078","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the study was to investigate the association between andropause symptoms and sickness absence in Japanese male workers over 2 years.</p><p><strong>Methods: </strong>A baseline survey asking about andropause symptoms, along with blood sampling for testosterone level, was conducted in June 2009. A total of 418 men (mean age = 52.4 years, SD = 8.6) participated and were followed through 2011. Hazard ratios (HRs) and 95% confidence intervals (CIs) for sickness absence were calculated using Cox proportional hazard models.</p><p><strong>Results: </strong>During the follow-up period, 31 of 35 participants who took sickness absences had physical illnesses. A higher andropause symptom score was associated with an increased risk of sickness absence. Testosterone deficiency (<350 ng/dL) was not associated with sickness absence. Among the subscales of andropause symptoms, the somatic symptom score was positively associated with sickness absence, whereas testosterone deficiency combined with high sexual symptoms was not associated with sickness absence. Results were similar when limited to sickness absence because of physical illness. No significant interaction between andropause symptoms and testosterone deficiency was found.</p><p><strong>Conclusions: </strong>Non-specific andropause symptoms unrelated to testosterone deficiency were positively associated with sickness absence.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1545-1552"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1862078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38733423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can myocardial performance index predict early cardiac risks in erectile dysfunction?","authors":"İsa Ardahanlı,&nbsp;Mehmet Celik","doi":"10.1080/13685538.2020.1768367","DOIUrl":"https://doi.org/10.1080/13685538.2020.1768367","url":null,"abstract":"<p><strong>Aim: </strong>Myocardial performance index (MPI) is an easy-to-apply and non-invasive method that shows both systolic and diastolic functions of the heart. In this study, it was aimed to evaluate the relationship between erectile dysfunction (ED) and MPI. <b>Methods:</b> The study included 45 male patients admitted to the urology outpatient clinic for ED and 48 healthy male volunteers. Echocardiographic evaluation of all participants was performed. Isovolumetric contraction time (IVCT), isovolumetric relaxation time (IVRT) and ejection time (ET) were measured. MPI was calculated using the IVCT + IVRT/ET formula. <b>Results:</b> The average age of the study population was 50 ± 5.3. Early diastolic mitral inflow (E)/late diastolic mitral inflow (A) ratio was significantly lower in the ED group (<i>p</i> ≤ 0.05). In the TDI evaluation between the groups, while early diastolic mitral annular velocity (Em) was significantly higher in the ED group, there was no significant difference in late diastolic mitral annular velocity (Am) and systolic peak velocities (Sm) (<i>p</i> < 0.01 and <i>p</i> = 0.417 and <i>p</i> = 0.092, respectively). While IVRT was significantly lower in the ED group (<i>p</i> < 0.05), there was no significant difference in IVCT and ET (<i>p</i> = 311 and <i>p</i> = 0.261, respectively). MPI was statistically significantly higher in the ED group (<i>p</i> < 0.05). <b>Conclusion:</b> ED has been found to affect MPI. This parameter, which is easily and non-invasively measured, can be used to predict the risk of CVDs in ED.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1355-1361"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1768367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37953471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of <i>Mucuna pruriens</i> (Linn.) on ageing induced damage in dorsal nerve of the penis and its implication on erectile function: an experimental study using albino rats.","authors":"Prakash Seppan,&nbsp;Ibrahim Muhammed,&nbsp;Karthik Ganesh Mohanraj,&nbsp;Ganesh Lakshmanan,&nbsp;Dinesh Premavathy,&nbsp;Sakthi Jothi Muthu,&nbsp;Khayinmi Wungmarong Shimray,&nbsp;Sathya Bharathy Sathyanathan","doi":"10.1080/13685538.2018.1439005","DOIUrl":"https://doi.org/10.1080/13685538.2018.1439005","url":null,"abstract":"<p><strong>Objective: </strong>To study the effect of ethanolic seed extract of <i>Mucuna pruriens</i> on damaged dorsal nerve of the penis (DNP) in aged rat in relation to penile erection.</p><p><strong>Methods: </strong>The rats were divided into four groups Young (3 months), Aged (24 - 28 months), Aged + <i>M. pruriens,</i> and Young + <i>M. pruriens</i> (200 mg/kg b.w/60 days) and were subjected to the hypophysial - gonadal axis, nerve conduction velocity (NCV), and penile reflex. DNP sections were stained with nitric oxide synthase (nNOS), nicotinamide adenine dinucleotide phosphate (NaDPH) diaphorase, androgen receptor (AR), and osmium tetroxide. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) staining, electron microscopy(EM) and histometric analyses were done.</p><p><strong>Results: </strong>Significant disturbance in hypophysial - gonadal axis was noted in aged rat. With reduced number of myelinated fibers, diameter, vacuolization, indentation of the myelin sheath, and degeneration. nNOS and its cofactor (NaDPH diaphorase) were reduced in aged rat DNP. NCV was slow in aged rats and concomitant poor penile reflex was also noted. AR showed reduced expression in aged rat DNP when compared to young and control groups. TUNEL positive cells were increased in aged rat DNP. These pathological changes were remarkably reduced or recovered in <i>M. pruriens</i> treated aged rats.</p><p><strong>Conclusions: </strong>The results indicate a multi-factorial therapeutic activity in penile innervations towards sustaining the penile erection in the presence of the extract in aged rats and justifying the claim of traditional usage.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"313-326"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1439005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35834082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum bicarbonate level improves specificity of Berlin Sleep Questionnaire for obstructive sleep apnea.","authors":"Mazlum Dursun,&nbsp;Hadice Selimoğlu Şen,&nbsp;Süreyya Yılmaz,&nbsp;Melike Demir,&nbsp;Gökhan Kırbaş,&nbsp;Mahşuk Taylan","doi":"10.1080/13685538.2020.1801623","DOIUrl":"https://doi.org/10.1080/13685538.2020.1801623","url":null,"abstract":"<p><p>Several questionnaires have been developed to assist the diagnostic process in obstructive sleep apnea syndrome (OSAS). Berlin Sleep Questionnaire (BSQ) represents a validated screening tool for OSAS. Totally 450 patients admitted to the Sleep Center at Dicle University Medical Faculty were included prospectively. A risk analysis was performed for presence of OSAS using the BSQ. Arterial blood gas measurements were performed including bicarbonate (HCO3) level. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of BSQ for presence of OSAS and severe OSAS were determined. In patients with arterial HCO₃ >24.94 mEq/L; sensitivity, specificity, PPV and NPV, of the BSQ were 93.04, 57.1, 98.3, and 23.5%, respectively. The addition of arterial HCO₃ value increased the sensitivity of the BSQ in detecting OSAS patients. Although the cost of sleep studies is high for false positives from the BSQ plus arterial HCO3 level, this cost should be compared with the loss of work efficiency and severe healthcare costs of undiagnosed cases in the future. Therefore, finding possible OSAS cases in primary care health centers is important and adding serum HCO3 value to BSQ questionnaire may contribute to this topic.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1480-1486"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1801623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38229387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal carotid artery anomaly in oropharynx as a rare cause of sore throat.","authors":"Amira Nasser Al Hail,&nbsp;Nasfareen Zada,&nbsp;Ahmad Al-Juboori,&nbsp;Asharaf Ayinikunnan","doi":"10.1080/13685538.2020.1800630","DOIUrl":"https://doi.org/10.1080/13685538.2020.1800630","url":null,"abstract":"<p><strong>Background: </strong>Anomaly of internal carotid artery (ICA) is a very rare variation. In almost all the cases, the anomaly was on the right side. This right-sided predominance may be attributed to anatomical influences and factors affecting blood pressure.</p><p><strong>Case report: </strong>A 67-years-old man presented to ear, nose and throat (ENT) outpatient clinic in Al Wakra Hospital complain of sore throat, there was associated medical co-morbidities (diabetic, hypertensive, hyperlipidemia and coronary artery diseases). ENT examination showed a pulsating, bulging mass on the right posterolateral oropharyngeal wall with normal mucosal covering. CT scan with contrast showed aberrant course of the right ICA which is coursing medially in prevertebral space and right posterolateral hypopharyngeal wall over a length of approximately 1.7 cm, making an acute U-turn before resuming the normal course and its distal aspects, only a thin layer of mucosa noted over the aberrant course of ICA.</p><p><strong>Conclusion: </strong>Anomaly of ICA must be kept in mind in the evaluation of patients with sore throat associated with oropharyngeal mass especially in old-aged patients with atherosclerotic diseases.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1467-1470"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1800630","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38308534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the clinical efficacy of simultaneous transurethral resection of both bladder cancer and the prostate: a systematic review and meta-analysis.","authors":"Li Zhou,&nbsp;Xinglong Liang,&nbsp;Kaizhong Zhang","doi":"10.1080/13685538.2020.1718637","DOIUrl":"https://doi.org/10.1080/13685538.2020.1718637","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to examine the clinical efficacy of simultaneous transurethral resection of bladder cancer and the prostate (TURBT + TURP) in non-muscle invasive bladder cancer (NMIBC) and benign prostatic hyperplasia (BPH) patients.</p><p><strong>Method: </strong>We conducted systematic research in PubMed, EMBASE, and Cochrane Library databases to identify retrospective studies and prospective randomized controlled trials (RCTs) comparing patient outcomes between TURBT + TURP and TURBT-only patients. The meta-analysis was conducted using Review Manager 5.3.</p><p><strong>Results: </strong>We identified eight relevant studies involving a total of 1032 patients. We found that patients that underwent TURBT + TURP exhibited significantly lower recurrence rates [odds ratio (OR), 0.70; 95% confidence interval (CI), 0.53-0.93; <i>p</i> = .01] and increased maximal urinary flow rate (Qmax) (WMD, 5.92; 95% CI, 4.67-7.16; <i>p</i> < .001) compared with patients that underwent TURBT-only. However, rates of recurrence at the prostatic urethra/bladder neck and bladder tumor progression, as well as the time to recurrence did not differ significantly between these two groups.</p><p><strong>Conclusions: </strong>Simultaneous TURBT + TURP can be safely performed in patients with NMIBC and BPH and improves patient quality of life, without any risk of increasing tumor recurrence or metastasis rates. Comprehensive RCTs are needed to confirm the results of this study.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1182-1193"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1718637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37611999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years.","authors":"Mingquan Chen,&nbsp;Xiong Chen,&nbsp;Yuanqing Dai,&nbsp;Zhiming Yang,&nbsp;Xiaobo Zhang,&nbsp;Dongjie Li","doi":"10.1080/13685538.2019.1607284","DOIUrl":"https://doi.org/10.1080/13685538.2019.1607284","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the safety and efficacy of wide local excision combined with aminolevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of scrotal Paget's disease in patients of advanced age.</p><p><strong>Methods: </strong>Data were collected for 16 patients (mean age, 68.44 years) with scrotal Paget's disease treated with wide local excision combined with ALA PDT and followed up from June 2014 to February 2018. Pathological examination after wide local excision confirmed Paget's disease. The patients underwent three courses of ALA PDT postoperatively and were followed up to determine the curative effect and complications in the short and middle term.</p><p><strong>Results: </strong>The disease duration ranged from 4 to 76 months (mean, 36 months). Ten patients underwent simple excision, six underwent skin flap transfer, and two required reoperations due to skin flap necrosis and infection. The patients were followed up for 3 to 42 months after ALA PDT, during which time two patients developed metastasis (recurrence rate, 12.50%). No other serious complications occurred during follow-up except for lower limb movement disorder in one patient (6.25%).</p><p><strong>Conclusions: </strong>Wide local excision combined with ALA PDT shows good clinical efficacy and a low complication rate in patients of advanced age with scrotal Paget's disease.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"854-859"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1607284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37370241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma thiols in prostate cancer.","authors":"Suleyman Sahin,&nbsp;Fatih Karataş","doi":"10.1080/13685538.2019.1631273","DOIUrl":"https://doi.org/10.1080/13685538.2019.1631273","url":null,"abstract":"Sir, We greatly appreciated one of the recently published article entitled Does plasma thiol and disulphide be a new marker for prostate cancer in prostate-specific antigen level between 10 and 20ng/mL by Topaktas et al. in your journal. The authors performed a prospective study investigating the plasma total thiol (TT), native thiol (NT), and disulfide (SS) levels as potential new biomarkers for the diagnosis of prostate cancer (PC), combining serum TT, NT, and SS levels with serum PSA measurements in 76 participants with elevated PSA levels ranging 0–20ng/mL, and further concluding that serum TT levels may help guide detecting PC, particularly with PSA levels between 10 and 20ng/ml [1]. However, we would like to kindly challenge some of the findings of the study as there seems to be confusing and conflicting parts as indicated below. As previously and generally shown in the literature, serum TT, NT, and SS levels were found to be significantly low in benign proliferative pathologies and cancer disease compared to healthy subjects and also shown to be independent predictors of poor survival [2,3]. In the present study, the authors found serum TT, NT, and SS levels higher in Group 1 than those of Group 2, with no significant difference. However, in the discussion part, they reported the following conclusion; “although not statistically significant, when PSA levels were between 10 and 20 (group 2), serum TT and NT levels were found to be high” as indicated by their own words in the manuscript. The results and conclusion appear to be discordant, hence having a likelihood of a huge confounder. How do the authors explain these inconsistent findings? One another important finding needs to be clarified is that authors have mentioned from a recent study [4] investigating the role of thiol/disulfide homeostasis in the differentiation of benign diseases from PC, which concluded that serum TT and NT levels were significantly higher in patients with PC than those found in patients with benign diseases. Of course, the literature can include various results; however, in order to support their results, the authors have cited another paper [5], which evaluated thiol/disulfide homeostasis prior to and 6months following radical prostatectomy in PC patients reporting that decreased TT and total antioxidant status levels weakened anti-oxidant defense mechanism in patients with PC, and further concluding that increased oxidative stress in PC patients may have a role in the etiopathogenesis of PC. However, the results of the two studies mentioned in the manuscript oppose to each other, hence need to be clarified. There are deficiencies in terms of Material – Method. The authors did not specify whether serum samples were obtained immediately by centrifugation and the Celcius degree to which they were stored. Moreover, another important point is that the researchers did not state whether they stored serum samples for the same period on average, according to the PSA gro","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"914"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1631273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37376977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}