Liquid biopsy in prostate cancer: current status and future challenges of clinical application.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2021-12-01 DOI:10.1080/13685538.2021.1944085

Yaqiong Wang, Zili Wang, Xiaokun Gang, Guixia Wang

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引用次数: 9

Abstract

Purpose: Liquid biopsy refers to the detection and analysis of the components from biological fluids non-invasively, including circulating tumor cells, nucleic acids, and extracellular vesicles (EVs). It is necessary to review the clinical value of liquid biopsy assays in PC and explore its potential application.

Materials and methods: We systematically reviewed of PubMed was performed to identify relevant literature on potential clinical applications of circulating tumor cells, circulating nucleic acids, and EVs in prostate cancer (PC).

Results: Liquid biopsy has emerged as a powerful tool to elucidate dynamic genomic, transcriptomic, and epigenomic tumor profiling in real-time. Here, the potential clinical applications of liquid biopsy include early detection, prognosis of survival, assessment of treatment response, and mechanisms of drug resistance in PC.

Conclusions: Liquid biopsy provides great value in diagnosis, prognosis, and treatment response in PC. Characterization of liquid biopsy components provides benefits both to unravel underlying resistance mechanisms and to exploit novel clinically actionable targets in PC. In addition, we suggest that analysis of multiparametric liquid biopsies should be analyzed comprehensively, assisting in monitoring tumor characteristics in real-time, guiding therapeutic selection, and early therapeutic switching during disease progression.

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前列腺癌液体活检:临床应用现状及未来挑战。

目的:液体活检是指对生物液体中的成分进行无创检测和分析，包括循环肿瘤细胞、核酸和细胞外囊泡(EVs)。有必要回顾液体活检在前列腺癌中的临床价值并探讨其潜在的应用前景。材料和方法:我们系统地回顾了PubMed，以确定循环肿瘤细胞、循环核酸和ev在前列腺癌(PC)中的潜在临床应用的相关文献。结果:液体活检已成为实时阐明动态基因组、转录组和表观基因组肿瘤分析的有力工具。在这里，液体活检的潜在临床应用包括早期发现、生存预后、治疗反应评估和PC耐药机制。结论:液体活检对PC的诊断、预后和治疗效果有重要价值。液体活检成分的表征为揭示潜在的耐药机制和开发新的临床可操作的PC靶点提供了好处。此外，我们建议对多参数液体活检的分析进行综合分析，以帮助实时监测肿瘤特征，指导治疗选择，并在疾病进展过程中早期切换治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.