Aging Male最新文献

{"title":"Association between oxidative balance score and benign prostatic hyperplasia: an analysis based on the NHANES from 2003 to 2008.","authors":"Feihong Xie, Zongke Yang","doi":"10.1080/13685538.2025.2611694","DOIUrl":"10.1080/13685538.2025.2611694","url":null,"abstract":"<p><strong>Purpose: </strong>The pathophysiology of benign prostatic hyperplasia (BPH), a prevalent condition among aging males, remains unclear. Given emerging evidence implicating oxidative stress (OS) in prostatic pathogenesis, this study investigated the association between the comprehensive Oxidative Balance Score (OBS) and BPH prevalence.</p><p><strong>Materials and methods: </strong>The National Health and Nutrition Examination Survey (NHANES) database was selected to determine BPH using a self-report questionnaire, and multivariate logistic regression was performed to explore the correlation between OBS and BPH. Smoothed curve fitting, threshold effect analysis, and stratified analysis were performed.</p><p><strong>Results: </strong>The present study, which ultimately included 621 participants, showed that after adjusting for potential confounders, an increase in OBS was associated with a slightly increased risk of developing BPH compared with the lowest tertile (T1) (OR = 1.07, 95% CI: 1.02,1.13, <i>P</i> = 0.015; OR = 1.09, 95% CI: 1.01, 1.17, <i>P</i> = 0.029). Smoothed curve fitting showed that when OBS was >21, the risk of developing BPH was associated with a 27% increase in the risk (OR = 1.27, 95% CI: 1.13, 1.43).</p><p><strong>Conclusion: </strong>This study reveals a significant non-linear association between OBS and BPH: when OBS > 21, higher OBS scores are associated with an increased risk of BPH.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2611694"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-mediated pathways between red blood cell traits and prostate cancer: a causal relationship network based on Mendelian randomization evaluation.","authors":"Ting Yang, Jinyu Zhang, Jiongzheng Li, Quanshun Yan, Jing Li","doi":"10.1080/13685538.2026.2641901","DOIUrl":"10.1080/13685538.2026.2641901","url":null,"abstract":"<p><strong>Background: </strong>Although both the immune and hematopoietic systems play important roles in prostate cancer (PCa), few studies have comprehensively investigated the combined influence of these systems on PCa risk.</p><p><strong>Method: </strong>The datasets used to construct causal networks for evaluation via Mendelian randomization and mediation Mendelian randomization (MMR). Nine analytical approaches were applied to evaluate the causal associations.</p><p><strong>Result: </strong>The findings revealed that red blood cell count (RBC) and red cell distribution width (RDW) were related to a modest increased risk of PCa, while mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were related to a modest reduced risk. Further, MMR analyses identified that HLA-DR on dendritic cells mediated the causal effect of RBC on PCa, with a mediated proportion of 12.09%, and that IgD⁺ CD38^- B cell % B cell mediated the effects of RDW and MCHC on PCa, with mediating proportions of 15.07% and 25.96%, respectively. Moreover, the IgD⁺ CD38^- B cell % lymphocytes mediated the causal effect of MCHC on PCa, with a mediated proportion of 29.03%.</p><p><strong>Conclusion: </strong>RBC, RDW, MCH, and MCHC were related to the risk of PCa. Immune cells act as major mediators in this relationship.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2641901"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the atherogenic index of plasma in response to once-daily tadalafil in men with erectile dysfunction.","authors":"Cem Tuğrul Gezmiş, Nusret Can Çilesiz, Mehmet Uzut, Mustafa Satılmışoğlu, Ali Eroğlu, Buğra Çetin, Mahmut Selman Mert, Mustafa Bahadır Can Balcı","doi":"10.1080/13685538.2026.2737481","DOIUrl":"https://doi.org/10.1080/13685538.2026.2737481","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) significantly affects quality of life, and phosphodiesterase type 5 inhibitors, including tadalafil, are main treatment options. Treatment response varies, and vasculometabolic disturbances may reduce responsiveness.</p><p><strong>Methods: </strong>In this prospective single-centre cohort study, men aged ≥40 years with ED initiating tadalafil 5 mg once daily were followed for 12 weeks. AIP was calculated as log₁₀(triglycerides/HDL-C) after conversion to mmol/L. The primary outcome was a ≥4-point increase in IIEF-EF. Firth penalised logistic regression and ROC analyses were performed.</p><p><strong>Results: </strong>Among 134 men, the response rate was 73.1%. Nonresponders had higher baseline AIP (0.196 ± 0.271 vs 0.070 ± 0.224, <i>p </i>= 0.008), higher BMI (28.8 ± 4.19 vs 27.4 ± 3.28 kg/m², <i>p </i>= 0.042), and higher prevalence of DM (30.6% vs 12.2%, <i>p </i>= 0.013). Each 0.1-unit AIP increase was independently associated with nonresponse (adjusted OR 1.20, 95% CI 1.01-1.44, <i>p </i>= 0.036), as was DM (adjusted OR 3.39, 95% CI 1.15-10.45, <i>p </i>= 0.027). ROC analysis yielded an AUC of 0.650 (95% CI 0.540-0.760, <i>p </i>= 0.008), with an optimal cutoff of 0.130.</p><p><strong>Conclusion: </strong>Higher baseline AIP was independently associated with nonresponse to once-daily tadalafil in men with ED, suggesting AIP may offer additional prognostic information, though further validation is needed.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2737481"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of frailty index with all-cause mortality in US adults with testosterone deficiency: mediation by the platelet-to-HDL-C ratio (PHR).","authors":"Yang Sun, Min Yin, Libin Zhou","doi":"10.1080/13685538.2025.2609402","DOIUrl":"https://doi.org/10.1080/13685538.2025.2609402","url":null,"abstract":"<p><strong>Background: </strong>The frailty index (FI), reflecting cumulative health deficits, is a strong predictor of adverse outcomes in older adults. However, its prognostic value for mortality among patients with testosterone deficiency (TD) remains unclear.</p><p><strong>Methods: </strong>We analyzed 1,688 adults with TD from three NHANES cycles (2011-2016) with mortality follow-up through 2019. FI was constructed using a 49-item deficit model. Survival differences were evaluated with Kaplan-Meier curves, and survey-weighted Cox models assessed the association between FI and all-cause mortality. Restricted cubic splines and threshold analyses explored dose-response relationships. Mediation analysis examined the role of the platelet-to-HDL-C ratio (PHR).</p><p><strong>Results: </strong>Frail participants exhibited significantly higher mortality risk than non-frail individuals (log-rank <i>P</i> < 0.001). Per 1-SD increase in FI, mortality risk rose by 76% (HR = 1.76, 95% CI: 1.57-1.96, <i>P</i> < 0.001). Threshold analysis showed a sharp increase in mortality when FI exceeded 0.095, approximating the conventional pre-frailty cut-off. PHR mediated 8.46% of the FI-mortality association.</p><p><strong>Conclusion: </strong>Higher FI was independently associated with increased all-cause mortality in TD patients, partly mediated by PHR. These findings highlight the prognostic significance of frailty and suggest PHR as a potential marker for personalized risk stratification and targeted intervention.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2609402"},"PeriodicalIF":2.6,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization investigation into testosterone's trade-offs between longevity and reproductive fitness.","authors":"Zhu Liduzi Jiesisibieke, C Mary Schooling","doi":"10.1080/13685538.2026.2717455","DOIUrl":"https://doi.org/10.1080/13685538.2026.2717455","url":null,"abstract":"<p><strong>Background: </strong>Antagonistic pleiotropy between fertility and survival suggests testosterone may promote fertility at the expense of survival. We investigated sex-specific effects of testosterone on fertility (offspring number) and lifespan (proxied by maternal and paternal attained age), with blood pressure as a control outcome, adjusted for confounders such as body mass index (BMI) using Mendelian randomization.</p><p><strong>Methods: </strong>We identified independent (r² < 0.001) genetic variants strongly (<i>p</i> < 5e-8) predicting testosterone in men (bioavailable) and women (total) from the largest genome-wide association studies (GWAS), and applied them to the largest available sex-specific GWAS summary statistics for maternal and paternal attained age, participant fertility, and blood pressure adjusted for sex-specific BMI.</p><p><strong>Results: </strong>Testosterone in men (<i>n</i> = 184,205) was inversely associated with lifespan (-0.74 years per standard deviation increase, 95% confidence interval [CI] -1.32 to -0.16) and was positively associated with fertility (0.03 children, 95% CI: 0.01 to 0.05; <i>n</i> = 209,872) after BMI adjustment. Testosterone was not associated with lifespan or fertility in women. Testosterone was associated with the control outcome in men, i.e. higher diastolic blood pressure after BMI adjustment.</p><p><strong>Conclusions: </strong>Our findings in men are consistent with antagonistic pleiotropy, i.e. higher testosterone was associated with greater fertility but shorter lifespan.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2717455"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of machine learning prognostic models for overall survival in non-surgical prostate cancer patients with bone metastases.","authors":"Qilin Yang, Ben Wang, Yang Yang, Sheng Li, Yuchen Li, Qingsong Du, Erhao Bao","doi":"10.1080/13685538.2026.2644725","DOIUrl":"10.1080/13685538.2026.2644725","url":null,"abstract":"<p><strong>Objective: </strong>To construct and interpret a machine learning model for predicting overall survival in nonsurgical prostate cancer with bone metastases (PCBM).</p><p><strong>Methods: </strong>Data from 3,378 SEER database patients were utilized to develop machine learning survival models, with the best-performing model visually interpreted using SHAP.</p><p><strong>Results: </strong>The Extra Survival Trees (EST) model performed best (validation AUC = 0.694, C-index = 0.643). SHAP analysis identified the Gleason score as the most critical survival factor, significantly outweighing clinical T stage. Visceral metastasis and advanced age also markedly increased mortality risk.</p><p><strong>Conclusion: </strong>The EST model effectively assesses OS in nonsurgical PCBM. The Gleason score holds greater prognostic value than local anatomical staging in this cohort, suggesting clinicians should prioritize early, aggressive combination treatments for high-Gleason, high-burden patients.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2644725"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone replacement therapy in older men: skeletal outcomes and fracture risk.","authors":"Lukasz Szarpak, Mahdi Al-Jeabory, Jaroslaw Pecold, Maciej Maslyk","doi":"10.1080/13685538.2026.2655544","DOIUrl":"10.1080/13685538.2026.2655544","url":null,"abstract":"<p><strong>Introduction: </strong>Testosterone replacement therapy (TRT) is increasingly prescribed to older men with symptomatic testosterone deficiency, yet the balance of musculoskeletal benefits and harms remains uncertain.</p><p><strong>Objectives: </strong>To synthesise current evidence on TRT-related effects on bone, muscle, falls/fractures, and tendon outcomes in older men, and to contextualise these findings within plausible mechanisms and recent regulatory positions.</p><p><strong>Methods: </strong>We conducted a state-of-the-art narrative review of randomised controlled trials, meta-analyses, clinical guidelines, and large observational/registry-based studies assessing musculoskeletal and tendon endpoints in older men receiving TRT.</p><p><strong>Results: </strong>Across trials, TRT consistently increases lean mass and reduces fat mass, while improvements in strength and physical performance are generally modest and heterogeneous. Evidence indicates small-to-moderate increases in bone mineral density, particularly at the spine and hip, but robust proof of fracture prevention is lacking. In the Testosterone Trials, TRT improved several surrogate musculoskeletal measures but did not reduce falls. In the TRAVERSE fracture analysis, TRT did not lower fracture risk and a higher fracture incidence was reported in the TRT group (hazard ratio 1.43).</p><p><strong>Discussion: </strong>Observational data suggest an association between TRT initiation and tendon injury, although causal inference is limited by confounding and detection bias. A potential explanation is a temporal mismatch between relatively rapid gains in muscle capacity and slower adaptation of tendon and bone to increased loading.</p><p><strong>Conclusion: </strong>In older men with confirmed hypogonadism, TRT may improve body composition and selected functional outcomes, but it should not be considered a disease-modifying strategy for preventing falls or fractures. Careful patient selection, assessment of baseline fracture/tendon risk, and structured monitoring are warranted, particularly in the context of evolving regulatory warnings regarding TRT use for age-related low testosterone.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2655544"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal links between brain multimodal features (morphometry, metabolomics, networks) and erectile dysfunction: evidence from Mendelian randomization.","authors":"Li Xie, Changjing Wu, Fudong Fu, Shi Deng","doi":"10.1080/13685538.2026.2632959","DOIUrl":"10.1080/13685538.2026.2632959","url":null,"abstract":"<p><strong>Background: </strong>Integrating brain multimodal features (e.g. structural, functional, and cerebrospinal fluid metabolomic data) offers a promising approach to elucidate the neural mechanisms underlying erectile dysfunction (ED).</p><p><strong>Methods: </strong>Using two-sample Mendelian randomization, we assessed causal effects of 83 whole-brain morphological, 191 resting-state fMRI, and 338 cerebrospinal fluid metabolite phenotypes on ED. A <i>p</i>-value < 0.05 indicated statistical significance.</p><p><strong>Results: </strong>Reduced volumes in the left and right accumbens and enlarged volumes in the left pars opercularis and right putamen were associated with increased ED risk. Increased connectivity between occipital/precuneus and superior frontal gyrus (default/executive networks) elevated ED risk, while connectivity between postcentral/precentral and subcortical regions (motor/subcortical-cerebellum networks) reduced risk. Several metabolites were identified: elevated 4-Methylcatechol sulfate, adenine, gulonate, pyroglutamine, and thioproline increased ED risk, while higher cortisone, malate, phosphate, and X-21733 decreased risk.</p><p><strong>Conclusion: </strong>We identified four morphological, two functional connectivity, and nine metabolic causal relationships with ED, enhancing understanding and suggesting novel therapeutic targets.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2632959"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of urodynamics and prostate-specific antigen levels with acute urinary retention in patients with benign prostatic hyperplasia.","authors":"YueYan Weng","doi":"10.1080/13685538.2025.2597171","DOIUrl":"10.1080/13685538.2025.2597171","url":null,"abstract":"<p><strong>Objective: </strong>Benign prostatic hyperplasia (BPH) is a common urinary disease in elderly men, with acute urinary retention (AUR) severely impacting quality of life. Urodynamic abnormalities and prostate-specific antigen (PSA) levels reflect urinary obstruction and prostate enlargement/inflammation. This study was to correlate the two factors with AUR in BPH patients.</p><p><strong>Methods: </strong>A total of 120 BPH patients were divided into AUR group and non-AUR group, with 60 cases in each group. Clinical, laboratory, and urodynamic data were collected. Independent variables with significant differences in univariate analysis were included in multifactorial logistic regression analysis. The diagnostic value of urodynamic parameters and PSA for AUR in BPH patients was assessed. A spline regression model was established to analyze the relationship between AUR and PSA.</p><p><strong>Results: </strong>Elevated levels of urodynamic parameters volume at first desire to void (FDV), bladder compliance (BC), total PSA (tPSA), and free PSA (fPSA) were independent risk factors for AUR in BPH patients. FDV and tPSA showed high predictive efficacy, while BC and fPSA relatively weaker. tPSA was positively correlated with both FDV and BC. fPSA was positively correlated only with FDV.</p><p><strong>Conclusion: </strong>FDV and BC with tPSA and fPSA are significantly elevated in BPH patients with AUR and show a strong association.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2597171"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of metabolic heterogeneity of obesity with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH): longitudinal cohort and cross-sectional study.","authors":"Qingze Xiao, Wei Xiao","doi":"10.1080/13685538.2026.2685423","DOIUrl":"10.1080/13685538.2026.2685423","url":null,"abstract":"<p><strong>Background: </strong>Based on data from the China Health and Retirement Longitudinal Study (CHARLS) and a Hunan cross-sectional study, the study investigated the link between metabolic heterogeneity of obesity (MHO) and lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH).</p><p><strong>Methods: </strong>The cohort study included 2278 males, and the cross-sectional study included 851 males; all were divided into four BMI-metabolic categories: MHNW, MUNW, MHOO, and MUOO.</p><p><strong>Results: </strong>This cross-sectional study found LUTS/BPH patients were younger, more urban-dwelling, with higher education and MHOO/MUOO prevalence. Both studies showed age, residence, education, obesity, and metabolic heterogeneity were linked with LUTS/BPH; CHARLS also linked arthritis and liver illness to LUTS/BPH.</p><p><strong>Conclusions: </strong>Logistic regression showed unadjusted associations for MHOO (OR = 1.84, 95% CI: 1.22-2.78, <i>p</i> = 0.0038) and MUOO (OR = 1.59, 95% CI: 1.15-2.19, <i>p</i> = 0.0051), but only MHOO remained significant after adjusting for age and multiple factors, indicating that it was independently associated with LUTS/BPH regardless of confounders.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2685423"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}