IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-06-19 DOI: 10.1080/13685538.2025.2519035

Michael Zitzmann, Andrea Sansone, Emmanuele A Jannini, Hugh Jones, Alberto Ferlin, Bruno Lunenfeld

{"title":"Recommendations for diagnosis and treatment of the aging male with Klinefelter syndrome.","authors":"Michael Zitzmann, Andrea Sansone, Emmanuele A Jannini, Hugh Jones, Alberto Ferlin, Bruno Lunenfeld","doi":"10.1080/13685538.2025.2519035","DOIUrl":"https://doi.org/10.1080/13685538.2025.2519035","url":null,"abstract":"This is the inaugural recommendation for the management of the Aging Male with Klinefelter Syndrome (KS), a demographic characterized by primary hypogonadism in the presence of one or more supernumerary X-chromosomes with irregular gene-inactivation, and metabolic dysregulation, contributing a component of functional hypogonadism as aging in these men progresses. The unique constellation of symptoms spanning multiple organ systems and health domains necessitates specialized diagnostic and therapeutic strategies. Neglecting the specific needs of this population can precipitate a considerable decline in quality of life and overall health outcomes. Our recommendations advocate for a multidisciplinary approach involving endocrinologists, urologists, geneticists, mental health professionals, and other specialists, to address the complex interplay of hormonal imbalances, metabolic disorders, cardiovascular risk factors including arrhythmia, bone health concerns, psychological and sexual challenges, ophthalmological problems, and dental issues. By providing a structured framework for comprehensive and individualized care, these recommendations aim to bridge existing healthcare gaps, optimize well-being, and enhance the overall quality of life for aging men with KS.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2519035"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of erectile dysfunction and its association with age in patients with metastatic renal cell carcinoma: results from a prospective multicenter study. 转移性肾细胞癌患者勃起功能障碍患病率及其与年龄的关系：来自一项前瞻性多中心研究的结果

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-06-28 DOI: 10.1080/13685538.2025.2525853

Yulia Tishova, Ruslan Zukov, Lev Demidov, Pavel Borisov, Vladimir Kuznetsov, Valentina Leonenko, Anastasia Tarasova, Kristina Zakurdaeva, Ilya Tsimafeyeu

{"title":"Prevalence of erectile dysfunction and its association with age in patients with metastatic renal cell carcinoma: results from a prospective multicenter study.","authors":"Yulia Tishova, Ruslan Zukov, Lev Demidov, Pavel Borisov, Vladimir Kuznetsov, Valentina Leonenko, Anastasia Tarasova, Kristina Zakurdaeva, Ilya Tsimafeyeu","doi":"10.1080/13685538.2025.2525853","DOIUrl":"https://doi.org/10.1080/13685538.2025.2525853","url":null,"abstract":"Background: This study aimed to evaluate the prevalence of erectile dysfunction (ED) and assess its associations in a large cohort of patients with metastatic renal cell carcinoma (mRCC) prior to initiating and during therapy.Methods: In this prospective multicenter study, male patients with clear-cell mRCC were assessed. Erectile function was evaluated using the 5-item International Index of Erectile Function (IIEF-5), and general health status was assessed using the Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI-19). Associations between clinical factors and IIEF-5 scores were analyzed using multiple regression models.Results: Among 357 patients (median age 62.9 years), 69% reported negative changes in sexual life, and 77.8% had some degree of ED. 62% of patients reported no sexual activity. Although older age, poor or intermediate IMDC risk, and greater symptom severity were associated with lower IIEF-5 scores in univariate analyses, age was not an independent predictor of ED. Instead, ECOG performance status, hemoglobin levels, and FKSI-19 scores significantly predicted ED level.Conclusions: ED is highly prevalent among patients with mRCC and appears to be more strongly associated with general health and disease burden rather than age. These findings highlight the importance of evaluating sexual health in oncology settings, irrespective of age.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2525853"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials. 富血小板血浆（PRP）单独或联合低强度冲击波治疗（Li-SWT）治疗勃起功能障碍的疗效：7项随机对照试验的系统回顾和荟萃分析。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/13685538.2025.2472786

Zhongbao Zhou, Yongqiang Wang, Yumeng Chai, Tao Wang, Pu Yan, Yong Zhang, Xudong Yang

{"title":"The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials.","authors":"Zhongbao Zhou, Yongqiang Wang, Yumeng Chai, Tao Wang, Pu Yan, Yong Zhang, Xudong Yang","doi":"10.1080/13685538.2025.2472786","DOIUrl":"10.1080/13685538.2025.2472786","url":null,"abstract":"Background: The goal of this meta-analysis intended to identify the efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) as a therapy for erectile dysfunction (ED).Methods: This study integrated and analyzed the data using Cochrane method and GRADEpro GDT grading system. The registration number for this study was CRD42024618240.Result: Seven randomized controlled trials with 660 patients were analyzed. The results indicated that compared with the control group, IIEF score of patients in the PRP group improved significantly at 12-week (p = 0.03) and 24-week (p = 0.0004), while there was no significant difference at 4-week. The PRP group had no significant advantages over the control group in terms of MCID and SEP Q3. For peak systolic velocity, patients in the PRP group demonstrated greater improvement than those in the control group (p < 0.00001). Subgroup analysis revealed that adding PRP regimen can considerably improve IIEF scores of ED patients compared to using Li-SWT alone (p < 0.0001).Conclusion: PRP demonstrated a better efficacy in treating ED, especially during a follow-up period of 6 months. Compared with using Li-SWT alone, the addition of PRP can considerably improve the IIEF score of ED patients. These findings still required large-scale clinical trials for verification.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2472786"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The INTIMA: development and validation of a new psychometric tool for the evaluation of perceived 'Viagra Jealousy' in erectile dysfunction therapy. INTIMA：一种新的心理测量工具的开发和验证，用于评估勃起功能障碍治疗中感知的“伟哥嫉妒”。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-05-29 DOI: 10.1080/13685538.2025.2509006

Daniele Mollaioli, Andrea Sansone, Tommaso B Jannini, Bac Hoai Nguyen, Thang Cao Nguyen, Quan Minh Pham, Giacomo Ciocca, Emmanuele A Jannini

{"title":"The INTIMA: development and validation of a new psychometric tool for the evaluation of perceived 'Viagra Jealousy' in erectile dysfunction therapy.","authors":"Daniele Mollaioli, Andrea Sansone, Tommaso B Jannini, Bac Hoai Nguyen, Thang Cao Nguyen, Quan Minh Pham, Giacomo Ciocca, Emmanuele A Jannini","doi":"10.1080/13685538.2025.2509006","DOIUrl":"https://doi.org/10.1080/13685538.2025.2509006","url":null,"abstract":"Background: In erectile dysfunction (ED) management the partner could support therapies or may sabotage them, as in the phenomenon of the \"Viagra Jealousy\" (VJ). Thus, we aimed to study the extent of cognitive and emotional discomfort in communicating and sharing ED treatment by creating a new tool, called INTIMA (Impact of Negotiating Treatment Intake on Marital Intimacy/Alliance Assessment).Methods: 134 men diagnosed with ED completed a series of validated psychometric questionnaires, including INTIMA, the Fear of Intimacy Scale (FIS), and the Relationship Questionnaire (RQ). Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were conducted to assess the dimensionality and factorial validity of the INTIMA and its psychometric strength.Results: CFA confirmed a single-factor structure with robust goodness-of-fit indices (ꭓ2[9] = 11.7, p = 0.234; SRMR = 0.030; CFI = 0.991; TLI = 0.985; RMSEA = 0.047). The INTIMA demonstrated excellent internal consistency. Convergent validity was supported by significant correlation with FIS and adequate Average Variance Extracted. ROC analysis revealed high discriminatory power for detecting insecure attachment patterns, with an optimal cut-off score of 17.Conclusion: INTIMA is a reliable psychometric tool for assessing perceived VJ and predicting the risks of involving or not the partner in ED treatment and to identify optimal strategies for better adherence and outcomes.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2509006"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of androgen in peyronie plaque induction rats. 雄激素对血小板诱导大鼠的影响。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-06-15 DOI: 10.1080/13685538.2025.2520327

Göktan Alptuğ Öz, Mustafa Ozan Ataçer, Gökhan Çevik, Meltem Ayyıldız Mercan, Ebru Taştekin, Hakan Akdere

{"title":"Effect of androgen in peyronie plaque induction rats.","authors":"Göktan Alptuğ Öz, Mustafa Ozan Ataçer, Gökhan Çevik, Meltem Ayyıldız Mercan, Ebru Taştekin, Hakan Akdere","doi":"10.1080/13685538.2025.2520327","DOIUrl":"https://doi.org/10.1080/13685538.2025.2520327","url":null,"abstract":"Objective: Peyronie's disease and hypogonadism are believed to have a linear association; however, research has yielded conflicting results. This is the first histopathological study on this topic.Methodology: This study randomly assigned 40 three-month-old male Sprague-Dawley rats to five groups. We established Peyronie's model by injecting intratunical TGF-beta and 3% disodium phosphate dihydrate into four groups. One group received intratunical saline. The control group for the Peyronie's disease model was one group. In the other groups, the first had castration orchiectomy. The second group was the Peyronie's disease model control. The third group received intratunical saline injections. The fourth group received intraperitoneal testosterone injections, while the fifth received 0.5 mg of 5-alpha reductase inhibitor orally daily. We excised penile tissue for histopathology after a 30-day follow-up. Masson's trichrome staining found collagen and smooth muscle, picro-sirius staining found collagen III and collagen I, and hematoxylin and eosin staining found fibrosis.Results: Histopathological examination revealed significant differences in fibrosis, smooth muscle/collagen ratios, and collagen III/collagen I ratios. Comparing groupings without a control group revealed no statistically significant differences.Conclusion: This study explored testosterone's effect on Peyronie's disease in rats. Fibrosis was analyzed, but no significant changes were observed.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2520327"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and association of functional dyspepsia in the elderly patients: a systematic review and meta-analysis. 老年患者功能性消化不良的患病率及其相关性：系统回顾和荟萃分析。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-06-09 DOI: 10.1080/13685538.2025.2511801

Hui Guo, Shuya Zhong, Xiao Wang, Jun Chen

{"title":"Prevalence and association of functional dyspepsia in the elderly patients: a systematic review and meta-analysis.","authors":"Hui Guo, Shuya Zhong, Xiao Wang, Jun Chen","doi":"10.1080/13685538.2025.2511801","DOIUrl":"10.1080/13685538.2025.2511801","url":null,"abstract":"Background: In the elderly, diagnosing and treating functional dyspepsia may be more challenging. The objectives of the study were to evaluate the prevalence and association of functional dyspepsia in adult individuals and elderly populations (especially ≥64 years) in the year 2024-2025 literature available.Methods: The study included a search of electronic articles, electronic books, and electronic book chapters using the keywords \"dyspepsia\" and \"age\" in PubMed, PubMed Central, and Google.Results: A total of 27.5 ± 21.39%, 24.8 ± 21.86%, 23.83 ± 23.54%, 23.5 ± 25.06%, and 21.9 ± 24.63% are reported prevalence of dyspepsia in all study populations (1-100 years; 23 articles), for patients ≥50 years (20 articles), for patients >55 years (15 articles), for patients ≥64 years (15 articles), and for patients >70 years (12 articles), respectively. Mostly gastric symptoms, specific treatments, older age, and female gender were associated with functional dyspepsia.Conclusions: One in four individuals in every age group has functional dyspepsia among the included patients (25% of patients). The study reported a 23.5 ± 25.06% prevalence of functional dyspepsia for ≥64 years patients regardless of the definition used. Helicobacter pylori infection, specific treatments, female gender, poorer sleep quality, and smoking are independent factors for the prevalence of functional dyspepsia in ≥64 years patients.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2511801"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial urinary sphincter implantation after transperineal open reconstruction of post-prostatectomy vesicourethral anastomotic stenosis. 前列腺切除术后膀胱尿道吻合口狭窄经会阴开放性重建术后人工尿道括约肌植入术。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2024-12-10 DOI: 10.1080/13685538.2024.2436862

Phillip Marks, Roland Dahlem, Margit Fisch, Victor M Schuettfort, Malte W Vetterlein, Dejan K Filipas, Tim A Ludwig

{"title":"Artificial urinary sphincter implantation after transperineal open reconstruction of post-prostatectomy vesicourethral anastomotic stenosis.","authors":"Phillip Marks, Roland Dahlem, Margit Fisch, Victor M Schuettfort, Malte W Vetterlein, Dejan K Filipas, Tim A Ludwig","doi":"10.1080/13685538.2024.2436862","DOIUrl":"https://doi.org/10.1080/13685538.2024.2436862","url":null,"abstract":"Purpose: This study evaluates the effectiveness of artificial urinary sphincter (AUS) implantation following transperineal reanastomosis in men with vesicourethral anastomotic stenosis (VUAS) and stress urinary incontinence (SUI) after radical prostatectomy (RP), focusing on long-term explantation rates and urinary continence.Methods: Patients treated between 2009 and 2020 were retrospectively analyzed. Those undergoing AUS implantation post-transperineal reanastomosis for recurrent VUAS, excluding cases with prior pelvic irradiation and overactive bladder, were included. Primary outcomes were AUS explantation rates and patient-reported continence. Median follow-up was calculated using reverse Kaplan-Meier estimates, and explantation-free survival illustrated via Kaplan-Meier analyses.Results: At final follow-up, 19 patients were included at a median follow-up of 79 months. Explantation occurred in 16% (N = 3) of cases, with a median time to explantation of 107 months. No urethral erosion was observed. Explantation-free survival at 2, 5, and 10 years was 100%, 87%, and 73%, respectively. The median number of pads/day decreased significantly postoperatively, with 78% (N = 14) reporting subjective continence and 89% (N = 16) achieving social continence.Conclusion: AUS implantation following transperineal reanastomosis for VUAS post-RP offers favorable long-term outcomes, with low explantation rates and no erosion, making it a viable management strategy.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2436862"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concerns over the association between sperm DNA fragmentation and male infertility. 对精子DNA断裂与男性不育之间关系的担忧。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-04-29 DOI: 10.1080/13685538.2025.2498945

Brijesh Sathian, Hanadi Al Hamad, Javed Iqbal

引用次数: 0

Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study. 40岁及以上男性内脏脂肪指数与前列腺癌之间的关系：一项全国性横断面研究。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-01-08 DOI: 10.1080/13685538.2024.2449341

Wentao Yao, Jiacheng Wu, Hongzhi Wang, Zongming Jia, Yinyi Zhou, Chendi Yang, Feng Xu, Ying Kong, Yuhua Huang

{"title":"Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study.","authors":"Wentao Yao, Jiacheng Wu, Hongzhi Wang, Zongming Jia, Yinyi Zhou, Chendi Yang, Feng Xu, Ying Kong, Yuhua Huang","doi":"10.1080/13685538.2024.2449341","DOIUrl":"https://doi.org/10.1080/13685538.2024.2449341","url":null,"abstract":"Objectives: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.Methods: Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.Results: Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [-0.075 (-0.145, -0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [-0.282 (-0.557, -0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point.Conclusion: In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2449341"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central obesity and its association with benign prostatic hyperplasia: insights from a cross-sectional study of NHANES 2001-2008. 中心性肥胖及其与良性前列腺增生的关系：来自2001-2008年NHANES横断面研究的见解

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-05-05 DOI: 10.1080/13685538.2025.2498943

Haoran Wang, Runhua Tang, Huimin Hou, Ming Liu, Yue Wang, Jianye Wang, Jianyong Liu, Jianlong Wang

{"title":"Central obesity and its association with benign prostatic hyperplasia: insights from a cross-sectional study of NHANES 2001-2008.","authors":"Haoran Wang, Runhua Tang, Huimin Hou, Ming Liu, Yue Wang, Jianye Wang, Jianyong Liu, Jianlong Wang","doi":"10.1080/13685538.2025.2498943","DOIUrl":"https://doi.org/10.1080/13685538.2025.2498943","url":null,"abstract":"Background: Benign prostatic hyperplasia (BPH) is a common condition that affects elderly men, but its relationship with central obesity in the American population has not been adequately elucidated.Methods: In this study, we included a total of 4,625 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2001 to 2008. We calculated indices related to central obesity for each participant and then employed univariate logistic regression, multivariate logistic regression, restricted cubic splines (RCS), and Akaike's Information Criterion (AIC) analysis.Results: we found that the indices of Weight, Waist Circumference (WC), waist-to-Height Ratio (WHtR), and Body Roundness Index (BRI) were significantly elevated in the BPH group. In terms of dietary intake, we found that the intake of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, and cholesterol was significantly higher in the BPH group, with polyunsaturated fatty acids and cholesterol meeting the criteria for both univariate and multivariate regression analyses.Conclusion: Weight, WC, WHtR, and BRI can effectively improve the prediction of BPH, which may be associated with the high intake of polyunsaturated fatty acids and cholesterol. Appropriately adjusting the types and total amount of fat intake may prevent the occurrence of prostatic hyperplasia.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2498943"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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