IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-06-19 DOI: 10.1080/13685538.2025.2519035

Michael Zitzmann, Andrea Sansone, Emmanuele A Jannini, Hugh Jones, Alberto Ferlin, Bruno Lunenfeld

{"title":"Recommendations for diagnosis and treatment of the aging male with Klinefelter syndrome.","authors":"Michael Zitzmann, Andrea Sansone, Emmanuele A Jannini, Hugh Jones, Alberto Ferlin, Bruno Lunenfeld","doi":"10.1080/13685538.2025.2519035","DOIUrl":"https://doi.org/10.1080/13685538.2025.2519035","url":null,"abstract":"This is the inaugural recommendation for the management of the Aging Male with Klinefelter Syndrome (KS), a demographic characterized by primary hypogonadism in the presence of one or more supernumerary X-chromosomes with irregular gene-inactivation, and metabolic dysregulation, contributing a component of functional hypogonadism as aging in these men progresses. The unique constellation of symptoms spanning multiple organ systems and health domains necessitates specialized diagnostic and therapeutic strategies. Neglecting the specific needs of this population can precipitate a considerable decline in quality of life and overall health outcomes. Our recommendations advocate for a multidisciplinary approach involving endocrinologists, urologists, geneticists, mental health professionals, and other specialists, to address the complex interplay of hormonal imbalances, metabolic disorders, cardiovascular risk factors including arrhythmia, bone health concerns, psychological and sexual challenges, ophthalmological problems, and dental issues. By providing a structured framework for comprehensive and individualized care, these recommendations aim to bridge existing healthcare gaps, optimize well-being, and enhance the overall quality of life for aging men with KS.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2519035"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of erectile dysfunction and its association with age in patients with metastatic renal cell carcinoma: results from a prospective multicenter study. 转移性肾细胞癌患者勃起功能障碍患病率及其与年龄的关系：来自一项前瞻性多中心研究的结果

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-06-28 DOI: 10.1080/13685538.2025.2525853

Yulia Tishova, Ruslan Zukov, Lev Demidov, Pavel Borisov, Vladimir Kuznetsov, Valentina Leonenko, Anastasia Tarasova, Kristina Zakurdaeva, Ilya Tsimafeyeu

{"title":"Prevalence of erectile dysfunction and its association with age in patients with metastatic renal cell carcinoma: results from a prospective multicenter study.","authors":"Yulia Tishova, Ruslan Zukov, Lev Demidov, Pavel Borisov, Vladimir Kuznetsov, Valentina Leonenko, Anastasia Tarasova, Kristina Zakurdaeva, Ilya Tsimafeyeu","doi":"10.1080/13685538.2025.2525853","DOIUrl":"10.1080/13685538.2025.2525853","url":null,"abstract":"Background: This study aimed to evaluate the prevalence of erectile dysfunction (ED) and assess its associations in a large cohort of patients with metastatic renal cell carcinoma (mRCC) prior to initiating and during therapy.Methods: In this prospective multicenter study, male patients with clear-cell mRCC were assessed. Erectile function was evaluated using the 5-item International Index of Erectile Function (IIEF-5), and general health status was assessed using the Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI-19). Associations between clinical factors and IIEF-5 scores were analyzed using multiple regression models.Results: Among 357 patients (median age 62.9 years), 69% reported negative changes in sexual life, and 77.8% had some degree of ED. 62% of patients reported no sexual activity. Although older age, poor or intermediate IMDC risk, and greater symptom severity were associated with lower IIEF-5 scores in univariate analyses, age was not an independent predictor of ED. Instead, ECOG performance status, hemoglobin levels, and FKSI-19 scores significantly predicted ED level.Conclusions: ED is highly prevalent among patients with mRCC and appears to be more strongly associated with general health and disease burden rather than age. These findings highlight the importance of evaluating sexual health in oncology settings, irrespective of age.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2525853"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between lipid accumulation product and erectile dysfunction in hypertensive and diabetic men: a cross-sectional analysis of NHANES 2001-2004. 高血压和糖尿病男性中脂质积累产物与勃起功能障碍之间的关系：NHANES 2001-2004的横断面分析

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1080/13685538.2025.2563391

Maobin Yu, Ze Li, Hongsen Zeng, Jian Ma, Hang Deng, Meijun Liu, Tao Zhang, Zilong Xu, Peihai Zhang

{"title":"The association between lipid accumulation product and erectile dysfunction in hypertensive and diabetic men: a cross-sectional analysis of NHANES 2001-2004.","authors":"Maobin Yu, Ze Li, Hongsen Zeng, Jian Ma, Hang Deng, Meijun Liu, Tao Zhang, Zilong Xu, Peihai Zhang","doi":"10.1080/13685538.2025.2563391","DOIUrl":"https://doi.org/10.1080/13685538.2025.2563391","url":null,"abstract":"Background: Erectile dysfunction (ED) is associated with metabolic disorders like hypertension and diabetes. The lipid accumulation product (LAP), a marker of visceral fat and dyslipidemia, has not been well studied in relation to ED in these populations. This study examined the relationship between LAP and ED.Methods: A cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) 2001-2004 data included 756 men with hypertension or diabetes. Weighted multivariable logistic regression and restricted cubic spline (RCS) analysis evaluated LAP-ED associations, with subgroup analysis for effect modification.Results: ED prevalence was 43.65% (330/756). LAP correlated positively with ED risk (continuous: OR = 1.005, 95%CI:1.000-1.005). Highest vs lowest LAP quartile (Q4 vs Q1) showed 2.92-fold higher ED risk (OR = 2.92, 95%CI:1.21-7.06). RCS analysis indicated linear association (P for non-linearity = 0.290). Subgroup analysis showed no significant interactions.Conclusion: This study demonstrates a positive correlation between LAP and ED in men with diabetes or hypertension; further studies are needed to confirm findings and explore mechanisms.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2563391"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials. 富血小板血浆（PRP）单独或联合低强度冲击波治疗（Li-SWT）治疗勃起功能障碍的疗效：7项随机对照试验的系统回顾和荟萃分析。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/13685538.2025.2472786

Zhongbao Zhou, Yongqiang Wang, Yumeng Chai, Tao Wang, Pu Yan, Yong Zhang, Xudong Yang

{"title":"The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials.","authors":"Zhongbao Zhou, Yongqiang Wang, Yumeng Chai, Tao Wang, Pu Yan, Yong Zhang, Xudong Yang","doi":"10.1080/13685538.2025.2472786","DOIUrl":"10.1080/13685538.2025.2472786","url":null,"abstract":"Background: The goal of this meta-analysis intended to identify the efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) as a therapy for erectile dysfunction (ED).Methods: This study integrated and analyzed the data using Cochrane method and GRADEpro GDT grading system. The registration number for this study was CRD42024618240.Result: Seven randomized controlled trials with 660 patients were analyzed. The results indicated that compared with the control group, IIEF score of patients in the PRP group improved significantly at 12-week (p = 0.03) and 24-week (p = 0.0004), while there was no significant difference at 4-week. The PRP group had no significant advantages over the control group in terms of MCID and SEP Q3. For peak systolic velocity, patients in the PRP group demonstrated greater improvement than those in the control group (p < 0.00001). Subgroup analysis revealed that adding PRP regimen can considerably improve IIEF scores of ED patients compared to using Li-SWT alone (p < 0.0001).Conclusion: PRP demonstrated a better efficacy in treating ED, especially during a follow-up period of 6 months. Compared with using Li-SWT alone, the addition of PRP can considerably improve the IIEF score of ED patients. These findings still required large-scale clinical trials for verification.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2472786"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The INTIMA: development and validation of a new psychometric tool for the evaluation of perceived 'Viagra Jealousy' in erectile dysfunction therapy. INTIMA：一种新的心理测量工具的开发和验证，用于评估勃起功能障碍治疗中感知的“伟哥嫉妒”。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-05-29 DOI: 10.1080/13685538.2025.2509006

Daniele Mollaioli, Andrea Sansone, Tommaso B Jannini, Bac Hoai Nguyen, Thang Cao Nguyen, Quan Minh Pham, Giacomo Ciocca, Emmanuele A Jannini

{"title":"The INTIMA: development and validation of a new psychometric tool for the evaluation of perceived 'Viagra Jealousy' in erectile dysfunction therapy.","authors":"Daniele Mollaioli, Andrea Sansone, Tommaso B Jannini, Bac Hoai Nguyen, Thang Cao Nguyen, Quan Minh Pham, Giacomo Ciocca, Emmanuele A Jannini","doi":"10.1080/13685538.2025.2509006","DOIUrl":"https://doi.org/10.1080/13685538.2025.2509006","url":null,"abstract":"Background: In erectile dysfunction (ED) management the partner could support therapies or may sabotage them, as in the phenomenon of the \"Viagra Jealousy\" (VJ). Thus, we aimed to study the extent of cognitive and emotional discomfort in communicating and sharing ED treatment by creating a new tool, called INTIMA (Impact of Negotiating Treatment Intake on Marital Intimacy/Alliance Assessment).Methods: 134 men diagnosed with ED completed a series of validated psychometric questionnaires, including INTIMA, the Fear of Intimacy Scale (FIS), and the Relationship Questionnaire (RQ). Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were conducted to assess the dimensionality and factorial validity of the INTIMA and its psychometric strength.Results: CFA confirmed a single-factor structure with robust goodness-of-fit indices (ꭓ2[9] = 11.7, p = 0.234; SRMR = 0.030; CFI = 0.991; TLI = 0.985; RMSEA = 0.047). The INTIMA demonstrated excellent internal consistency. Convergent validity was supported by significant correlation with FIS and adequate Average Variance Extracted. ROC analysis revealed high discriminatory power for detecting insecure attachment patterns, with an optimal cut-off score of 17.Conclusion: INTIMA is a reliable psychometric tool for assessing perceived VJ and predicting the risks of involving or not the partner in ED treatment and to identify optimal strategies for better adherence and outcomes.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2509006"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of androgen in peyronie plaque induction rats. 雄激素对血小板诱导大鼠的影响。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-06-15 DOI: 10.1080/13685538.2025.2520327

Göktan Alptuğ Öz, Mustafa Ozan Ataçer, Gökhan Çevik, Meltem Ayyıldız Mercan, Ebru Taştekin, Hakan Akdere

{"title":"Effect of androgen in peyronie plaque induction rats.","authors":"Göktan Alptuğ Öz, Mustafa Ozan Ataçer, Gökhan Çevik, Meltem Ayyıldız Mercan, Ebru Taştekin, Hakan Akdere","doi":"10.1080/13685538.2025.2520327","DOIUrl":"https://doi.org/10.1080/13685538.2025.2520327","url":null,"abstract":"Objective: Peyronie's disease and hypogonadism are believed to have a linear association; however, research has yielded conflicting results. This is the first histopathological study on this topic.Methodology: This study randomly assigned 40 three-month-old male Sprague-Dawley rats to five groups. We established Peyronie's model by injecting intratunical TGF-beta and 3% disodium phosphate dihydrate into four groups. One group received intratunical saline. The control group for the Peyronie's disease model was one group. In the other groups, the first had castration orchiectomy. The second group was the Peyronie's disease model control. The third group received intratunical saline injections. The fourth group received intraperitoneal testosterone injections, while the fifth received 0.5 mg of 5-alpha reductase inhibitor orally daily. We excised penile tissue for histopathology after a 30-day follow-up. Masson's trichrome staining found collagen and smooth muscle, picro-sirius staining found collagen III and collagen I, and hematoxylin and eosin staining found fibrosis.Results: Histopathological examination revealed significant differences in fibrosis, smooth muscle/collagen ratios, and collagen III/collagen I ratios. Comparing groupings without a control group revealed no statistically significant differences.Conclusion: This study explored testosterone's effect on Peyronie's disease in rats. Fibrosis was analyzed, but no significant changes were observed.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2520327"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of prolonged sit-to-stand test duration and cardiovascular disease risk in Middle-aged and older adults: evidence from CHARLS. 中老年人坐立试验时间延长与心血管疾病风险的关系：来自CHARLS的证据

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-07-18 DOI: 10.1080/13685538.2025.2534558

Xiaofeng Zhang, Weili Li, Danchan Lu, Zhenhua Jin

{"title":"Relationship of prolonged sit-to-stand test duration and cardiovascular disease risk in Middle-aged and older adults: evidence from CHARLS.","authors":"Xiaofeng Zhang, Weili Li, Danchan Lu, Zhenhua Jin","doi":"10.1080/13685538.2025.2534558","DOIUrl":"https://doi.org/10.1080/13685538.2025.2534558","url":null,"abstract":"Background: The 5-repetition sit-to-stand (5STS) test, a common physical performance measure, has been associated with various health outcomes, but its relationship with cardiovascular disease (CVD) risk warrants further investigation.Objectives: This study examined the association between 5STS test duration and CVD risk in middle-aged and elderly Chinese adults.Methods: Data were from the China Health and Retirement Longitudinal Study (CHARLS). Cross-sectional and longitudinal analyses using linear and logistic regression models assessed the relationship between 5STS duration and CVD risk. Subgroup analyses and restricted cubic spline models explored effect modifiers and non-linear trends.Results: Longer 5STS duration was independently associated with higher CVD risk. Each additional second increased CVD odds (cross-sectional: OR = 1.03, 95% CI: 1.02-1.04; longitudinal: OR = 1.04, 95% CI: 1.02-1.06). A graded association was observed, with the highest quartile demonstrating approximately 1.5 times the risk compared to the lowest. Restricted cubic spline analysis indicated a steep risk increase at approximately 9.81 s.Conclusions: The 5STS test is a potential non-invasive predictor of CVD risk and may be useful for early detection in clinical settings. Further research across diverse populations is needed.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2534558"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic appetite regulation in elderly patients with type 2 diabetes mellitus and the role of asprosin and MIC-1. 老年2型糖尿病患者代谢食欲调节及阿泌素和MIC-1的作用。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-07-22 DOI: 10.1080/13685538.2025.2534563

Muharrem Bayrak, Büsra Karahan, Alev Lazoğlu Özkaya, Kenan Cadirci, Gamze Nur Yılmaz, Nur Pak, Adil Furkan Kılıç

{"title":"Metabolic appetite regulation in elderly patients with type 2 diabetes mellitus and the role of asprosin and MIC-1.","authors":"Muharrem Bayrak, Büsra Karahan, Alev Lazoğlu Özkaya, Kenan Cadirci, Gamze Nur Yılmaz, Nur Pak, Adil Furkan Kılıç","doi":"10.1080/13685538.2025.2534563","DOIUrl":"https://doi.org/10.1080/13685538.2025.2534563","url":null,"abstract":"Background and objectives: This study aimed to evaluate the potential associations between asprosin, Macrophage inhibitory cytokine-1 (MIC-1), and metabolic parameters related to appetite regulation in elderly individuals with and without type 2 diabetes mellitus (T2DM).Materials and methods: Eighty-six elderly patients (44 with T2DM, 42 non-diabetics) were evaluated. Appetite was assessed using the Three-Factor Eating Questionnaire (TFEQ), and serum levels of asprosin and (MIC-1) were measured using ELISA.Results: Asprosin and MIC-1 levels were significantly lower in T2DM patients (p = 0.032 and p < 0.001, respectively; compared to non-diabetics. In the diabetic group, uncontrolled eating was positively associated with waist circumference and ferritin levels, while emotional eating showed a positive correlation with systolic blood pressure and an inverse correlation with vitamin D levels, based on multivariate regression analysis. Among non-diabetics, triglyceride levels were negatively associated with emotional eating (p = 0.019). No statistically significant associations were found between appetite scores and serum levels of asprosin or MIC-1.Conclusion: Metabolic and circulatory factors, including waist circumference, serum ferritin, vitamin D [25(OH)D], triglycerides, and systolic blood pressure, appear to influence appetite regulation in elderly individuals. Despite reduced levels of asprosin and MIC-1 in T2DM patients, their independent roles in appetite regulation were not evident. Further studies to clarify these relationships.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2534563"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic analysis reveals a causal relationship between air pollution and erectile dysfunction. 基因分析揭示了空气污染与勃起功能障碍之间的因果关系。

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-09-15 DOI: 10.1080/13685538.2025.2557339

Zhenxing Wang, Zhanlong Zheng, Changhui Fan, Zhinan Jing, Xinfang Cao, Rongshen Guan, Weijun Yuan, Jingqi Wang

{"title":"Genetic analysis reveals a causal relationship between air pollution and erectile dysfunction.","authors":"Zhenxing Wang, Zhanlong Zheng, Changhui Fan, Zhinan Jing, Xinfang Cao, Rongshen Guan, Weijun Yuan, Jingqi Wang","doi":"10.1080/13685538.2025.2557339","DOIUrl":"10.1080/13685538.2025.2557339","url":null,"abstract":"Objective: To evaluate the causal relationship between air pollution and erectile dysfunction (ED).Methods: This study was evaluated by the method of double sample Mendelian random grouping (MR). The exposure data were from the GWAS data set of British biological bank (n = 461). Results the data were integrated into three cohorts (223805 healthy controls and 6175 ED patients). Inverse variance weighted (IVW) analysis was mainly used, supplemented by Mr egger regression, weighted median and Cochran's Q test. One analysis was reserved for quality control, and Bonferroni correction was used for multiple tests.Results: The increase of PM2.5 predicted by gene was significantly correlated with the increased risk of ED (IVW or = 1.65, 95% CI = 1.12 - 2.43, P = 0.010), which was still significant after Bonferroni correction (p < 1.67 × 10-2) After adjusting for confounding factors, multivariate MR analysis confirmed that PM2.5 had an independent causal effect on ed. Mr egger regression showed no horizontal pleiotropy (intercept P > 0.05), and no heterogeneity or abnormal single nucleotide polymorphisms were found.Conclusion: This is the first genetic evidence that PM2.5 is an independent risk factor for ED. it is emphasized that air pollution control is the key public health strategy for global ed prevention.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2557339"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Easy blood oxygen accumulation distribution area index (EBOADAI) integrating apneic events and hypoxemic burden: association with testosterone deficiency and sexual health in adult males. 纳入窒息事件和低氧血症负担的易血氧积累分布面积指数（EBOADAI）：与成年男性睾酮缺乏和性健康的关系

IF 2.6 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1080/13685538.2025.2568139

Longlong Fan, Wenyu Sun, Binghua Chen, Shengxiong Zhang, Shiqiang Zhang, Xu Yang, Yongsheng Li, Wenzhong Zheng

{"title":"Easy blood oxygen accumulation distribution area index (EBOADAI) integrating apneic events and hypoxemic burden: association with testosterone deficiency and sexual health in adult males.","authors":"Longlong Fan, Wenyu Sun, Binghua Chen, Shengxiong Zhang, Shiqiang Zhang, Xu Yang, Yongsheng Li, Wenzhong Zheng","doi":"10.1080/13685538.2025.2568139","DOIUrl":"https://doi.org/10.1080/13685538.2025.2568139","url":null,"abstract":"Background: The link between obstructive sleep apnea (OSA) and serum testosterone levels is still unclear.Method: This cross-sectional study analyzed data from the 2015-2016 NHANES cycle and an independent polysomnography (PSG) cohort (validation cohort). We examined associations between OSA severity and risks of testosterone deficiency. Additionally, we quantified the capacity of BOADAI and apnea-hypopnea index to assess testosterone deficiency in OSA patients.Results: The study included 2,359 participants from the NHANES cohort and 172 from the standardized PSG cohort. A negative correlation was identified between OSA and serum testosterone levels. After multivariable adjustment, OSA patients exhibited a 31% increased risk of testosterone deficiency (odds ratio [OR] = 1.31, 95% confidence interval [CI]: (1.02, 1.70), p = 0.03). This risk escalated to 67% in severe OSA (OR = 1.67, 95% CI: (1.04-2.68), p = 0.03) versus controls. The BOADAI showed stronger inverse correlation with testosterone(r = -0.37) and remained independently associated with testosterone deficiency (OR = 2.37, 95% CI:(1.12-5.32), p = 0.01).Conclusions: This study provided evidence of a negative association between OSA and serum testosterone levels. The BOADAI, measurable at home via a finger-clip oximeter, provides an effective and more convenient monitoring alternative for monitoring testosterone levels in OSA management.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2568139"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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