Metabolic appetite regulation in elderly patients with type 2 diabetes mellitus and the role of asprosin and MIC-1.

IF 2.6 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-07-22 DOI:10.1080/13685538.2025.2534563

Muharrem Bayrak, Büsra Karahan, Alev Lazoğlu Özkaya, Kenan Cadirci, Gamze Nur Yılmaz, Nur Pak, Adil Furkan Kılıç

{"title":"Metabolic appetite regulation in elderly patients with type 2 diabetes mellitus and the role of asprosin and MIC-1.","authors":"Muharrem Bayrak, Büsra Karahan, Alev Lazoğlu Özkaya, Kenan Cadirci, Gamze Nur Yılmaz, Nur Pak, Adil Furkan Kılıç","doi":"10.1080/13685538.2025.2534563","DOIUrl":null,"url":null,"abstract":"Background and objectives: This study aimed to evaluate the potential associations between asprosin, Macrophage inhibitory cytokine-1 (MIC-1), and metabolic parameters related to appetite regulation in elderly individuals with and without type 2 diabetes mellitus (T2DM).Materials and methods: Eighty-six elderly patients (44 with T2DM, 42 non-diabetics) were evaluated. Appetite was assessed using the Three-Factor Eating Questionnaire (TFEQ), and serum levels of asprosin and (MIC-1) were measured using ELISA.Results: Asprosin and MIC-1 levels were significantly lower in T2DM patients (p = 0.032 and p < 0.001, respectively; compared to non-diabetics. In the diabetic group, uncontrolled eating was positively associated with waist circumference and ferritin levels, while emotional eating showed a positive correlation with systolic blood pressure and an inverse correlation with vitamin D levels, based on multivariate regression analysis. Among non-diabetics, triglyceride levels were negatively associated with emotional eating (p = 0.019). No statistically significant associations were found between appetite scores and serum levels of asprosin or MIC-1.Conclusion: Metabolic and circulatory factors, including waist circumference, serum ferritin, vitamin D [25(OH)D], triglycerides, and systolic blood pressure, appear to influence appetite regulation in elderly individuals. Despite reduced levels of asprosin and MIC-1 in T2DM patients, their independent roles in appetite regulation were not evident. Further studies to clarify these relationships.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2534563"},"PeriodicalIF":2.6000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Male","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13685538.2025.2534563","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objectives: This study aimed to evaluate the potential associations between asprosin, Macrophage inhibitory cytokine-1 (MIC-1), and metabolic parameters related to appetite regulation in elderly individuals with and without type 2 diabetes mellitus (T2DM).

Materials and methods: Eighty-six elderly patients (44 with T2DM, 42 non-diabetics) were evaluated. Appetite was assessed using the Three-Factor Eating Questionnaire (TFEQ), and serum levels of asprosin and (MIC-1) were measured using ELISA.

Results: Asprosin and MIC-1 levels were significantly lower in T2DM patients (p = 0.032 and p < 0.001, respectively; compared to non-diabetics. In the diabetic group, uncontrolled eating was positively associated with waist circumference and ferritin levels, while emotional eating showed a positive correlation with systolic blood pressure and an inverse correlation with vitamin D levels, based on multivariate regression analysis. Among non-diabetics, triglyceride levels were negatively associated with emotional eating (p = 0.019). No statistically significant associations were found between appetite scores and serum levels of asprosin or MIC-1.

Conclusion: Metabolic and circulatory factors, including waist circumference, serum ferritin, vitamin D [25(OH)D], triglycerides, and systolic blood pressure, appear to influence appetite regulation in elderly individuals. Despite reduced levels of asprosin and MIC-1 in T2DM patients, their independent roles in appetite regulation were not evident. Further studies to clarify these relationships.

查看原文本刊更多论文

老年2型糖尿病患者代谢食欲调节及阿泌素和MIC-1的作用。

背景和目的：本研究旨在评估伴有和不伴有2型糖尿病（T2DM）的老年人中，巨噬细胞抑制因子-1 （MIC-1）和与食欲调节相关的代谢参数之间的潜在关联。材料与方法：对86例老年患者（T2DM 44例，非糖尿病42例）进行评价。采用三因素进食问卷（TFEQ）评估食欲，采用ELISA法检测血清asprosin和MIC-1水平。结果：2型糖尿病患者Asprosin、MIC-1水平明显降低（p = 0.032, p = 0.019）。在食欲评分和血清asprosin或MIC-1水平之间没有发现统计学上显著的关联。结论：腰围、血清铁蛋白、维生素D [25(OH)D]、甘油三酯和收缩压等代谢和循环因素可能影响老年人的食欲调节。尽管2型糖尿病患者的asprosin和MIC-1水平降低，但它们在食欲调节中的独立作用并不明显。进一步的研究来澄清这些关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.