The association between lipid accumulation product and erectile dysfunction in hypertensive and diabetic men: a cross-sectional analysis of NHANES 2001-2004.

IF 2.6 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI:10.1080/13685538.2025.2563391

Maobin Yu, Ze Li, Hongsen Zeng, Jian Ma, Hang Deng, Meijun Liu, Tao Zhang, Zilong Xu, Peihai Zhang

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引用次数: 0

Abstract

Background: Erectile dysfunction (ED) is associated with metabolic disorders like hypertension and diabetes. The lipid accumulation product (LAP), a marker of visceral fat and dyslipidemia, has not been well studied in relation to ED in these populations. This study examined the relationship between LAP and ED.

Methods: A cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) 2001-2004 data included 756 men with hypertension or diabetes. Weighted multivariable logistic regression and restricted cubic spline (RCS) analysis evaluated LAP-ED associations, with subgroup analysis for effect modification.

Results: ED prevalence was 43.65% (330/756). LAP correlated positively with ED risk (continuous: OR = 1.005, 95%CI:1.000-1.005). Highest vs lowest LAP quartile (Q4 vs Q1) showed 2.92-fold higher ED risk (OR = 2.92, 95%CI:1.21-7.06). RCS analysis indicated linear association (P for non-linearity = 0.290). Subgroup analysis showed no significant interactions.

Conclusion: This study demonstrates a positive correlation between LAP and ED in men with diabetes or hypertension; further studies are needed to confirm findings and explore mechanisms.

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高血压和糖尿病男性中脂质积累产物与勃起功能障碍之间的关系：NHANES 2001-2004的横断面分析

背景：勃起功能障碍（ED）与代谢障碍如高血压和糖尿病有关。脂质积累产物（LAP）是内脏脂肪和血脂异常的标志，但在这些人群中与ED的关系尚未得到很好的研究。方法：对2001-2004年全国健康与营养调查（NHANES）数据进行横断面分析，其中包括756名高血压或糖尿病患者。加权多变量logistic回归和限制性三次样条（RCS）分析评估了LAP-ED的相关性，并通过亚组分析进行了效果修正。结果：ED患病率为43.65%（330/756）。LAP与ED风险呈正相关（连续：OR = 1.005, 95%CI:1.000-1.005）。最高与最低LAP四分位数（Q4 vs Q1）显示ED风险高2.92倍（OR = 2.92, 95%CI:1.21-7.06）。RCS分析显示线性相关（非线性P = 0.290）。亚组分析显示无显著的相互作用。结论：本研究表明男性糖尿病或高血压患者LAP与ED呈正相关；需要进一步的研究来证实这些发现并探索其机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.