Aging Male最新文献_第2页

Current treatment for erectile dysfunction: an umbrella review of systematic reviews and meta-analyses. 当前勃起功能障碍的治疗：系统综述和荟萃分析的综述。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-06 DOI: 10.1080/13685538.2026.2640765

Jian Ma, Jintao Wei, Jinze Li, Maobin Yu, Shikuan Lu, Hongsen Zeng, Lei Xu, Ye Dong, Ziyang Ma, Peihai Zhang

{"title":"Current treatment for erectile dysfunction: an umbrella review of systematic reviews and meta-analyses.","authors":"Jian Ma, Jintao Wei, Jinze Li, Maobin Yu, Shikuan Lu, Hongsen Zeng, Lei Xu, Ye Dong, Ziyang Ma, Peihai Zhang","doi":"10.1080/13685538.2026.2640765","DOIUrl":"10.1080/13685538.2026.2640765","url":null,"abstract":"Objective: This umbrella review aimed to summarize and provide a general evaluation of the effectiveness of current treatments for erectile dysfunction (ED) and assess the quality of evidence.Methods: This umbrella review available in PubMed, Web of Science, the Cochrane Library, and Embase, covering studies published up to October 2025, was conducted. The International Index of Erectile Function (IIEF) or its simplified version and the erectile hardness score (EHS) were used as endpoints to evaluate the effectiveness of the treatments.Results: Of 1191 studies, 23 published meta-analyses were extracted, yielding 42 summary effects on IIEF (n = 20), the international index of erectile function-5 (IIEF-5) (n = 9), the international index of erectile function-erectile function (IIEF-EF) (n = 6), and EHS (n = 7) on 36 interventions. All meta-analyses were analyzed via the AMSTAR-2, of which 13 (56.5%) were rated as critically low quality, 7 (30.5%) were rated as low quality, 2 (8.7%) were rated as moderate quality, and 1 (4.3%) was rated as high quality. Of the 42 summary effects, only two studies were rated as high-quality and moderate-quality respectively, whereas 47.6% (n = 20) and 47.6% (n = 20) were rated low and very low, respectively.Conclusions: The current evidence base for ED treatments is predominantly of low or very low quality. While statistically significant improvements in ED were observed with both pharmacological and nonpharmacological interventions, these findings should be interpreted with caution due to the limited number of patients and the subjective nature of outcome indicators. The treatment landscape for ED is increasingly diverse, yet the reliability of the evidence is poor. Further well-designed studies on single treatments and high-quality meta-analyses of intertreatment comparisons are urgently recommended.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2640765"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal role of acupuncture in post orgasmic illness syndrome. 针刺在性高潮后疾病综合征中的时间作用。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-09-09 DOI: 10.1080/13685538.2026.2730012

Ali Mohamed Ali Ismail, Shahul Hameed Pakkir Mohamed, Yousef M Alshehre

引用次数: 0

Association between triglyceride-glucose index and AVSS-rigiscan test parameters in men with erectile dysfunction. 男性勃起功能障碍患者甘油三酯-葡萄糖指数与AVSS-rigiscan测试参数的关系

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-02-11 DOI: 10.1080/13685538.2026.2625521

Xin Qian, Yangyang Gong, Can Ran, Rui Yang, Xiang Cai, Linlin Xiang, Mingdong Jiang, Hui Tian, Yougang Feng, Hongjian Liu

{"title":"Association between triglyceride-glucose index and AVSS-rigiscan test parameters in men with erectile dysfunction.","authors":"Xin Qian, Yangyang Gong, Can Ran, Rui Yang, Xiang Cai, Linlin Xiang, Mingdong Jiang, Hui Tian, Yougang Feng, Hongjian Liu","doi":"10.1080/13685538.2026.2625521","DOIUrl":"10.1080/13685538.2026.2625521","url":null,"abstract":"Background: Although elevated triglyceride-glucose (TyG) index has been shown to affect penile erection, the relationship between the TyG index and erection at the tip or base of the penis has not been extensively studied.Methods: We investigated the effect of the TyG index on penile tip and base erection through a retrospective analysis, including 276 patients with erectile dysfunction (ED) as the case group and 28 men without sexual dysfunction (from health checkups or premarital examinations) as the control group. The correlation between TyG index levels and penile tip/base erection was analyzed.Results: We found that TyG index levels were negatively correlated with the average event rigidity of the tip (r = -0.220; p = 0.0001), the average event rigidity of the base (r = -0.143; p = 0.013), and the average maximum rigidity of the tip (r = -0.165; p = 0.004). Additionally, TyG index levels showed a negative correlation with ∆ tumescence of the tip (r = -0.124; p = 0.031).Conclusion: Our data indicate that elevated TyG index is significantly associated with ED, and TyG index levels are negatively correlated with the parameters of the AVSS-RigiScan test.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2625521"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS). 评价α-1阻滞剂、5α-还原酶抑制剂和PDE5I治疗BPH的安全性：基于FDA不良事件报告系统（FAERS）的现实世界不良事件的歧化分析。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-24 DOI: 10.1080/13685538.2026.2647019

Zihao Zhao, Changjing Wu, Yang Xiong, Wei Wang, Feng Qin, Jiuhong Yuan

{"title":"Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS).","authors":"Zihao Zhao, Changjing Wu, Yang Xiong, Wei Wang, Feng Qin, Jiuhong Yuan","doi":"10.1080/13685538.2026.2647019","DOIUrl":"10.1080/13685538.2026.2647019","url":null,"abstract":"Objective: To compare the real-world safety profiles of α1-adrenoceptor antagonists (α1-blockers), 5α-reductase inhibitors (5ARIs), and phosphodiesterase type 5 inhibitor (PDE5I) used in the treatment of benign prostatic hyperplasia (BPH).Methods: This retrospective pharmacovigilance study analyzed FDA Adverse Event Reporting System (FAERS) from Q1 of 2004 to Q2 of 2025. Reports of adverse events (AEs) in male BPH patients receiving AUA guideline-recommended drugs including α-1 blockers (tamsulosin, silodosin, doxazosin, and alfuzosin), 5ARIs (finasteride and dutasteride), and tadalafil were extracted. Disproportionality analysis was performed to detect significant safety signals. AEs were classified using MedDRA terms.Results: Among 9,540 unique reports and 25,796 AEs entries, patients aged 65-80 years accounted for the majority of the reports. Most AEs occurred within 30 days of treatment initiation. Hospitalization was the most common serious outcome. Sixteen significant AEs were detected, including pollakiuria, gynecomastia, breast pain and so on, with distinct reporting patterns across drug classes.Conclusions: This large-scale pharmacovigilance analysis identified distinct post-marketing safety signals among guideline-recommended pharmacotherapies for BPH, confirming known risks and suggesting potential novel adverse-event signals warranting further investigation.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2647019"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is transurethral enucleation of the prostate combined with internal incision of peripheral zone abscesses a safe treatment for prostate multilocular abscesses? 经尿道前列腺核切除联合外周区脓肿内切是治疗前列腺多房脓肿的安全方法吗？

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-02-13 DOI: 10.1080/13685538.2026.2627014

Jing Du, Xingchen Yuan, Yongchuan Wang, Kai Wang, Liwei Wang, Haijun Zhou, Zhiyong Yu, Anji Ren, Xiaolu Lun, Wenshun Liu, Teng Shen, Yuxing Bi, Bangmin Han

{"title":"Is transurethral enucleation of the prostate combined with internal incision of peripheral zone abscesses a safe treatment for prostate multilocular abscesses?","authors":"Jing Du, Xingchen Yuan, Yongchuan Wang, Kai Wang, Liwei Wang, Haijun Zhou, Zhiyong Yu, Anji Ren, Xiaolu Lun, Wenshun Liu, Teng Shen, Yuxing Bi, Bangmin Han","doi":"10.1080/13685538.2026.2627014","DOIUrl":"10.1080/13685538.2026.2627014","url":null,"abstract":"Background: To evaluate the effectiveness and safety of performing transurethral enucleation of the prostate in combination with internal incision of prostate abscesses located in the peripheral zone for multilocular prostate abscesses.Methods: This retrospective study included 10 patients aged 45 to 89 years who were diagnosed with multilocular prostate abscesses. All patients underwent transurethral bipolar plasmakinetic enucleation of enlarged prostatic adenomas with internal incision of peripheral zone abscesses. Clinical and demographic characteristics, intraoperative parameters, urination status, postoperative complications, and recurrence of abscesses were systematically analyzed to determine the outcomes of this procedure.Results: All patients successfully completed the operation without intraoperative complications. After surgery, infection-related parameters, including white blood cell count, C-reactive protein, procalcitonin and body temperature, returned to normal ranges, while urinary function indices such as post-void residual urine volume, maximum urinary flow rate, International Prostate Symptom Score, and quality-of-life score showed significant improvement compared with preoperative values. During follow-up, all patients achieved complete resolution of their prostate abscesses without evidence of recurrence.Conclusions: Transurethral enucleation of the prostate combined with internal incision of peripheral zone abscesses appears to be a safe and reliable surgical approach for multilocular prostate abscesses.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2627014"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146196171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between chronic inflammation status and serum testosterone and free testosterone in adult males. 成年男性慢性炎症状态与血清睾酮和游离睾酮的关系。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-02-18 DOI: 10.1080/13685538.2026.2632964

Si-Zheng Zhang, Yu-Hang Meng, Shuai-Dang Qi, Jie Wu, Liang Su, Yong-Zheng Jiao

{"title":"Association between chronic inflammation status and serum testosterone and free testosterone in adult males.","authors":"Si-Zheng Zhang, Yu-Hang Meng, Shuai-Dang Qi, Jie Wu, Liang Su, Yong-Zheng Jiao","doi":"10.1080/13685538.2026.2632964","DOIUrl":"10.1080/13685538.2026.2632964","url":null,"abstract":"Background: Chronic inflammation may contribute to biochemical hypogonadism, but evidence regarding composite inflammatory indicators is limited. This study examined the associations of the systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) with serum testosterone and free testosterone (FT) in adult males.Methods: Data were obtained from NHANES 2011-2016 and 2021-2023, including 7,576 men for serum testosterone and 3,590 for FT. Multivariable regression, smoothing curves, threshold effect, and age-stratified analyses were conducted.Results: Higher SIRI and AISI were significantly associated with lower serum testosterone and FT levels (P < 0.0001). Testosterone levels were lowest in the highest quartiles of SIRI and AISI. Nonlinear inverse associations with serum testosterone were observed for both indices, and AISI also showed a nonlinear association with FT, while SIRI showed a linear inverse association. A positive association with biochemical hypogonadism was observed only when defined by serum testosterone. The inverse associations were consistent across all ages for serum testosterone but were evident for FT only in men aged 20-39 and ≥60 years.Conclusion: SIRI and AISI are independently associated with lower serum testosterone in men, while associations with FT appear age-dependent.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2632964"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An L-shaped curve relating Hs-CRP/HDL-C(CHR) index to kidney stone disease (KSD) in US adult participants: a cross-sectional study. 美国成年参与者Hs-CRP/HDL-C（CHR）指数与肾结石疾病（KSD）相关的l形曲线：一项横断面研究

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-28 DOI: 10.1080/13685538.2026.2650010

Baolei Shi, Wenbing Yuan, Shuangning Liu, Yu Dai, Xiaoke Sun, Yatao Jia

引用次数: 0

Association between circadian syndrome and frailty in middle-aged and elderly people: a longitudinal study. 中老年人昼夜节律综合征与虚弱之间的关系：一项纵向研究。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-04-02 DOI: 10.1080/13685538.2026.2647061

Yingxin Peng, Ningning Dai, Dan Zhao

{"title":"Association between circadian syndrome and frailty in middle-aged and elderly people: a longitudinal study.","authors":"Yingxin Peng, Ningning Dai, Dan Zhao","doi":"10.1080/13685538.2026.2647061","DOIUrl":"10.1080/13685538.2026.2647061","url":null,"abstract":"Background: This study aimed to investigate the cross-sectional and longitudinal associations between Circadian syndrome (CircS) and frailty using nationally representative data from CHARLS (China Longitudinal Study of Health and Retirement).Methods: The cross-sectional study enrolled 9584 Chinese adults aged 45 years and older in 2011. Logistic regression models were used to investigate the associations of CircS with frailty status and frailty index. The longitudinal study enrolled 6363 eligible participants. Cox regression models were used for longitudinal association analysis and subgroup analyses.Results: Cross-sectional analysis showed that CircS was positively correlated with the frailty index (β = 0.041, 95% CI: 0.036-0.045, p < 0.001) and frailty status (OR = 2.008, 95% CI: 1.770-2.279, p < 0.001). During the 7-year follow-up, a total of 1,833 participants (28.81%) developed frailty. CircS was significantly associated with the risk of developing frailty status (HR = 1.499, 95% CI: 1.367-1.644, P < 0.001).Conclusion: This study provides the first longitudinal evidence that CircS is a significant predictor of frailty among older adults. These findings underscore the importance of circadian health in the aging process and suggest that targeting CircS through lifestyle and behavioral interventions may represent a promising strategy for frailty prevention and management.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2647061"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of dutasteride on storage symptoms in men with lower urinary tract symptoms: a REDUCE trial analysis. 度他雄胺对有下尿路症状的男性尿潴留症状的影响：一项REDUCE试验分析

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-04-21 DOI: 10.1080/13685538.2026.2660387

Alexander Hernandez-Tirado, Renning Zheng, Eman Dadashian, Farnoosh Nik-Ahd, Daniel Moreira, Stephen J Freedland

{"title":"The effect of dutasteride on storage symptoms in men with lower urinary tract symptoms: a REDUCE trial analysis.","authors":"Alexander Hernandez-Tirado, Renning Zheng, Eman Dadashian, Farnoosh Nik-Ahd, Daniel Moreira, Stephen J Freedland","doi":"10.1080/13685538.2026.2660387","DOIUrl":"10.1080/13685538.2026.2660387","url":null,"abstract":"Background: Dutasteride is used to treat voiding symptoms; its impact on storage symptoms is unclear.Methods: We reviewed 8122 men in the placebo and dutasteride arms from the REDUCE trial. Lower urinary tract symptoms outcomes were measured with international prostate symptom score and subscores.Results: At 2-year follow-up, dutasteride significantly reduced the total International Prostate Symptom Score and voiding subscore versus placebo (both p < 0.001), but not storage symptoms (p = 0.09) or nocturia (p = 0.2). By 4 years, improvements in the total score and voiding subscores remained, but now extended to storage symptoms (p < 0.001) and nocturia (p = 0.003), though the impact on storage symptoms was modest (0.62 points improvement).Conclusion: While dutasteride reduces storage symptoms, it takes several years, and the overall effect is modest and unlikely to be clinically meaningful. Timely, comprehensive lower urinary tract symptoms management may require additional therapy.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2660387"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing testosterone deficiency in primary care: an international expert consensus. 在初级保健中管理睾酮缺乏：国际专家共识。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-08-26 DOI: 10.1080/13685538.2026.2716438

Janine David, Carol Burté, Emmett Byrne, Paul Downie, Geoffrey Hackett, T Hugh Jones, Mohit Khera, Martin Miner, Abdulmaged M Traish, Femke Anne Maria Van Gennip, Michael Zitzmann, Abraham Morgentaler

{"title":"Managing testosterone deficiency in primary care: an international expert consensus.","authors":"Janine David, Carol Burté, Emmett Byrne, Paul Downie, Geoffrey Hackett, T Hugh Jones, Mohit Khera, Martin Miner, Abdulmaged M Traish, Femke Anne Maria Van Gennip, Michael Zitzmann, Abraham Morgentaler","doi":"10.1080/13685538.2026.2716438","DOIUrl":"10.1080/13685538.2026.2716438","url":null,"abstract":"Background: Testosterone deficiency (TD) has traditionally been managed by specialists, yet there is growing public demand for general practitioners (GPs) to become involved in the care of these men. Most TD cases initially present to GPs, and common medical conditions associated with TD are already managed by GPs, including obesity, diabetes, anaemia, and impaired mood. However, there has been scant clinical guidance or education for GPs on this topic.Aim: To provide consensus-based expert clinical guidance on the management of TD for GPs.Design and setting: International multidisciplinary consensus initiative sponsored by the Androgen Society.Method: An international panel of experts- including GPs, endocrinologists, urologists, andrologists, and clinical chemists- convened in Amsterdam in November 2025 to establish key points of guidance (resolutions) for GPs wishing to manage TD. Resolutions were subsequently refined in an iterative consensus process.Results: Unanimous consensus was achieved for all ten resolutions, covering diagnosis, treatment, monitoring, and recommendations for referral to specialists for selected populations. Key points included the requirement of symptoms and/or signs of TD combined with low values of either total or free testosterone to initiate testosterone therapy (TTh); total testosterone concentrations less than 12 nmol/L (350 ng/dl) are considered low; and monitoring for symptom response and biochemical abnormalities is essential. Large randomized clinical trial data reveals TTh is not associated with increased cardiovascular or prostate cancer risks.Conclusion: These evidence-based, clinical recommendations serve as a practical guide for GPs wishing to incorporate the evaluation and management of men with TD into their practices.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2716438"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0