Aging Male最新文献_第2页

Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients. 勃起功能障碍患者全身炎症反应指数对他达拉非无反应患者的预测价值。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-02-19 DOI: 10.1080/13685538.2025.2467157

Resul Sobay

{"title":"Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients.","authors":"Resul Sobay","doi":"10.1080/13685538.2025.2467157","DOIUrl":"10.1080/13685538.2025.2467157","url":null,"abstract":"Background: Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one of the primary treatments. However, some patients remain unresponsive, necessitating further investigation.Objective: To investigate the association between systemic inflammatory response index (SIRI) and tadalafil unresponsiveness in erectile dysfunction patients.Methods: A total of 106 male patients who applied to the Andrology outpatient clinic with ED complaints between January and June 2024 were included in the study. Patients were started on daily tadalafil 5 mg therapy, and response was assessed after one month using the International Index of Erectile Function Erectile Function domain (IIEF-EF). SIRI values, calculated using neutrophil, monocyte, and lymphocyte counts, were compared between tadalafil-responsive and unresponsive groups.Results: Tadalafil unresponsiveness was observed in 48.1% of patients. Non-responders had significantly higher mean age(57.44 ± 12.52 vs. 47.22 ± 11.49, p < 0.001), BMI(27.22 ± 3.17 vs. 25.85 ± 2.92, p = 0.023), and SIRI values(1.33 ± 0.82 vs. 1.02 ± 0.40, p = 0.016) compared to responders. Multivariate analysis identified age(OR = 1,641, p = 0.001) and SIRI(OR = 2.420, p = 0.014) as independent predictors of tadalafil failure. ROC curve analysis revealed a SIRI cutoff of 1.03 (AUC = 0.617) with 69.1% sensitivity and 61.2% specificity.Conclusion: Findings suggest that systemic inflammation plays a key role in ED pathophysiology and may impair PDE5i efficacy.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2467157"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the association between consumption of different types of beverages and erectile dysfunction in US men: evidence from NHANES 2003-2004 data. 探索美国男性饮用不同类型饮料与勃起功能障碍之间的关系：来自2003-2004年NHANES数据的证据。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2024-12-10 DOI: 10.1080/13685538.2024.2438821

Liwei Wu, Bing Li, Hang Zhou, Xiaoqiang Liu

{"title":"Exploring the association between consumption of different types of beverages and erectile dysfunction in US men: evidence from NHANES 2003-2004 data.","authors":"Liwei Wu, Bing Li, Hang Zhou, Xiaoqiang Liu","doi":"10.1080/13685538.2024.2438821","DOIUrl":"https://doi.org/10.1080/13685538.2024.2438821","url":null,"abstract":"Background: The aim of this study was to examine the relationship between the type/frequency of consuming beverages and ED among men in America.Methods: We used data on erectile function and the frequency of beverage consumption from the National Health and Nutrition Examination Survey (NHANES) 2003-2004. Associations between ED and beverage consumption were analyzed using univariate and multivariate logistic regression. We also stratified by age and adjusted for potential confounders using propensity score matching (PSM).Results: After fully adjusting for covariates, logistic regression showed that regular grape juice consumption (≥ 5 times/week) was related to a lower prevalence of ED (OR = 0.21, 95% CI: 0.08-0.54, p = 0.001). Subgroup analyses found that this correlation remained significant for those over 40 years of age (all p < 0.05). After PSM adjustment, the association between grape juice consumption and ED remained statistically significant (OR = 0.12, 95% CI: 0.03-0.44, p = 0.001). Various beverage types, encompassing tomato, orange, apple, pineapple, and lemonade juices, as well as soft drinks, exhibited a correlation with ED in the initial univariate regression analysis.Conclusions: In men, regular intake of grape juice (≥ 5 times/week) was associated with a lower prevalence of ED, which was particularly significant in men over 40 years of age.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2438821"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostatitis and male infertility. 前列腺炎与男性不育。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-04-24 DOI: 10.1080/13685538.2025.2494550

Lin Hua, Xintao Gao, Junfeng Zhan, Xiaolong Wu, Hanchao Liu

引用次数: 0

Comment on: "the efficacy of platelet-rich plasma (PRP) alone or in combination with low-intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials". 评论：“富血小板血浆（PRP）单独或联合低强度冲击波治疗（Li-SWT）治疗勃起功能障碍的疗效：7项随机对照试验的系统回顾和荟萃分析”。

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-05-12 DOI: 10.1080/13685538.2025.2504943

Hakan Anıl

引用次数: 0

Sperm DNA damage and disturbed chromatin condensation indexes (DFI and CMA3) in normozoospermic men with unexplained infertility problem. 正常精子男性不明原因不孕症患者精子DNA损伤及染色质凝聚指数（DFI和CMA3）紊乱

IF 2.7 4区医学

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-03-10 DOI: 10.1080/13685538.2025.2472774

Mehdi Abedinzadeh, Sara Abedinzadeh, Fatemeh Sadeghi-Nodoushan, Fatemeh Pourrajab

{"title":"Sperm DNA damage and disturbed chromatin condensation indexes (DFI and CMA3) in normozoospermic men with unexplained infertility problem.","authors":"Mehdi Abedinzadeh, Sara Abedinzadeh, Fatemeh Sadeghi-Nodoushan, Fatemeh Pourrajab","doi":"10.1080/13685538.2025.2472774","DOIUrl":"10.1080/13685538.2025.2472774","url":null,"abstract":"Purpose: The quantitatively measured sperm DNA damage and disturbed chromatin condensation indexes (%DNA fragmentation index [DFI%] and %high DNA staining index [%HDS]) and their relationships with sperm quality in normospermic men with unexplained infertility were investigated. The aim was also highlighting the impact of age on both DFI and CMA3 staining and on sperm quality, and their associations with male infertility.Methods: In this retrospective study, conventional semen tests, including sperm motility and morphological evaluations and DFI and disturbed chromatin condensation indexes (DFI, CMA3) were performed according to the World Health Organization (WHO) 2021 criteria. DFI and CMA3 were evaluated using sperm chromatin dispersion (SCD) and chromomycin A3 (CMA3) staining assays and then correlation and regression analysis were done.Results: By analyzing SCD and CMA3 results, notable differences were found in sperm parameters among different DFI and CMA3 groups (all p < 0.05). It was found that in the male fertility quality sperm concentration, progressive (PR)/non-progressive (NP) motility, immobility, and morphology were significantly associated with sperm DFI and CMA3, but not with age (p < 0.05).Conclusions: Sperm molecular index DFI and CMA3 negatively affect male fertility quality through semen parameters (sperm concentration, motility, and morphology). SCD and CMA3 indexes show a significant negative correlation with sperm quality in normospermic males, which highlights its role in the assessment of male fertility potential and molecular evaluation of infertility treatment.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2472774"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism. PDE5 抑制剂对伴有或不伴有性腺功能减退症的中老年患者的疗效和安全性。

IF 2.6 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2023-12-26 DOI: 10.1080/13685538.2023.2288347

Chunlin Wang, Hui Zhang, Fu Wang, Jun Guo, Jianlin Yuan, Guangdong Hou, Ming Gao, Zheng Li, Yan Zhang

{"title":"Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism.","authors":"Chunlin Wang, Hui Zhang, Fu Wang, Jun Guo, Jianlin Yuan, Guangdong Hou, Ming Gao, Zheng Li, Yan Zhang","doi":"10.1080/13685538.2023.2288347","DOIUrl":"10.1080/13685538.2023.2288347","url":null,"abstract":"Purpose: Although several reviews have evaluated the use of PDE5 inhibitors (PDE5i) for treating erectile dysfunction (ED), their specific use in middle-aged and old patients has not been fully evaluated. Given that elderly patients with ED often have a complex combination of systemic and sexual health risk factors, the safety and efficacy of PDE5i in such a context are hereby reviewed.Materials and methods: A thorough examination of existing literature has been conducted on PubMed.Results: PDE5i has good safety and efficacy, but the situation is more complex for patients with hypogonadism than those with normal testosterone levels, with reduced responsiveness to PDE5i. In this case, combination therapy with testosterone is recommended, safe and effective.Conclusions: Eliminating or reducing reversible risk factors and controlling or slowing the development of irreversible factors is an important foundation for using PDE5i to treat ED in all patients, especially middle-aged and elderly ones.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2288347"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139038163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erectile dysfunction in patient with obstructive sleep apnea: effects of continuous positive airway pressure. 阻塞性睡眠呼吸暂停患者的勃起功能障碍：持续气道正压的影响。

IF 2.6 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-02-22 DOI: 10.1080/13685538.2024.2317165

Hyeyun Kim, Keun Tae Kim, Won Chul Shin, Kwang Ik Yang, Ji Yong Ha, Yong Won Cho

{"title":"Erectile dysfunction in patient with obstructive sleep apnea: effects of continuous positive airway pressure.","authors":"Hyeyun Kim, Keun Tae Kim, Won Chul Shin, Kwang Ik Yang, Ji Yong Ha, Yong Won Cho","doi":"10.1080/13685538.2024.2317165","DOIUrl":"10.1080/13685538.2024.2317165","url":null,"abstract":"Background: Obstructive sleep apnea (OSA) is linked to various health complications, including erectile dysfunction (ED), which is more prevalent in individuals with OSA. This study explored ED in Korean OSA patients and assessed the impact of continuous positive airway pressure (CPAP) therapy on ED.Methods: A total of 87 male patients with OSA from four different sleep centers underwent physical measurements and completed sleep and mental health (MH) questionnaires, including the Korean version of the International index of erectile function (IIEF), before and three months after initiating CPAP therapy.Results: After three months of CPAP therapy, the patients demonstrated a significant improvement in ED as measured on the IIEF. However, the study found no significant correlation between the duration of CPAP use and the improvement in IIEF score. It did identify the SF36 quality of life assessment as a significant factor influencing ED improvement after CPAP.Conclusions: ED is a prevalent issue that escalates with age and is associated with OSA. CPAP therapy has shown potential in alleviating ED symptoms, particularly in those with underlying psychological conditions, although further research is required to confirm these findings and understand the underlying mechanisms.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2317165"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of masturbation Premature ejaculation diagnostic tool in diagnosing premature ejaculation in men without vaginal intercourse over the past six months: an observational study. 手淫早泄诊断工具在诊断过去六个月未进行阴道性交的男性早泄方面的有效性：一项观察性研究。

IF 2.7 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1080/13685538.2024.2411286

Zeyu Zhu, Zhihui Mao, Chunlin Wang, Xiaohong Chen, Zhuojie Liu, Yan Zhang

{"title":"Effectiveness of masturbation Premature ejaculation diagnostic tool in diagnosing premature ejaculation in men without vaginal intercourse over the past six months: an observational study.","authors":"Zeyu Zhu, Zhihui Mao, Chunlin Wang, Xiaohong Chen, Zhuojie Liu, Yan Zhang","doi":"10.1080/13685538.2024.2411286","DOIUrl":"https://doi.org/10.1080/13685538.2024.2411286","url":null,"abstract":"Background: Premature ejaculation (PE) is a common concern for men and their partners, but current diagnostic tools mainly focus on men who have vaginal intercourse. The Masturbation Premature Ejaculation Diagnostic Tool (MPEDT) was created to address this gap, but its effectiveness for men who only engage in self-masturbation has not been studied. This research aimed to determine the frequency of self-reported PE patients who do not have vaginal intercourse and to evaluate the diagnostic accuracy of MPEDT for this group.Method: The study involved 446 male patients aged 18 to 40, and 40 non-self-reported-PE and non-vaginal-intercourse healthy males. Participants completed the MPEDT questionnaire and reported their recent six-months sex frequency.Result: Among the patients seeking treatment for PE, 21.75% had not engaged in vaginal intercourse in the past six months. Of the PE patients who completed the MPEDT questionnaire (86 patients), 90.7% were diagnosed with masturbatory-PE (MPE). The sensitivity for self-reported MPE and specificity for self-reported non-MPE were 93.02% and 72.5%, respectively.Discussion: For patients who have not had vaginal intercourse in the past six months but engage in masturbation and seek treatment for PE, the PEDT may not effectively assess their ejaculatory function. The MPEDT, however, can effectively evaluate their ejaculatory function. This study also emphasizes the need for diagnostic tools tailored to this population.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2411286"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of platelet rich plasma in the treatment of erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials. 富血小板血浆治疗勃起功能障碍的疗效：随机对照试验的系统回顾和荟萃分析。

IF 2.6 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI: 10.1080/13685538.2024.2358944

Qiancheng Mao, Yingying Yang, Yang Liu, Hongquan Liu, Gonglin Tang, Xiaofeng Wang, Yuanshan Cui, Jitao Wu

{"title":"The efficacy of platelet rich plasma in the treatment of erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials.","authors":"Qiancheng Mao, Yingying Yang, Yang Liu, Hongquan Liu, Gonglin Tang, Xiaofeng Wang, Yuanshan Cui, Jitao Wu","doi":"10.1080/13685538.2024.2358944","DOIUrl":"10.1080/13685538.2024.2358944","url":null,"abstract":"Background: Erectile dysfunction (ED) is a common issue among males, and the use of platelet-rich plasma (PRP) therapy for treating ED has gained increasing attention, but there is still no conclusive evidence regarding its efficacy.Aim: To evaluate the efficacy of PRP therapy for ED.Methods: We systematically searched PubMed, Embase, Cochrane Library, and Web of Science databases up to November 2023 to identify randomized controlled trials (RCTs) on PRP therapy for ED. We used Review Manager version 5.4 for data analysis and management.Result: After applying inclusion and exclusion criteria for screening, a total of 4 studies involving 413 patients were finally included in our meta-analysis. According to our analysis, the PRP group showed significant advantages over the placebo group in terms of MCID at the first month (p = 0.03) and sixth months (p = 0.008), while there was no significant difference between the two groups at the third month (p = 0.19). Additionally, in terms of IIEF, PRP showed significantly better efficacy than placebo at the first, third, and sixth months (p < 0.00001).Conclusions: PRP shows more effectiveness in treating ED compared to placebo, offering hope as a potential alternative treatment for ED.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2358944"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Needs assessment survey among healthcare professionals to implement the 4Ms framework: a cross-sectional study from Qatar. 医疗保健专业人员实施 4Ms 框架的需求评估调查：来自卡塔尔的横断面研究。

IF 2.7 4区医学

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI: 10.1080/13685538.2024.2401161

Hanadi Al Hamad, Sameer Acharath Valappil, Brijesh Sathian

{"title":"Needs assessment survey among healthcare professionals to implement the 4Ms framework: a cross-sectional study from Qatar.","authors":"Hanadi Al Hamad, Sameer Acharath Valappil, Brijesh Sathian","doi":"10.1080/13685538.2024.2401161","DOIUrl":"https://doi.org/10.1080/13685538.2024.2401161","url":null,"abstract":"Background: Worldwide, the evidence-based 4Ms framework of the Age-Friendly Health System (AFHS) improves the experience of caring for older adults. This study aimed to examine healthcare professionals' perceptions, attitudes, and behaviors regarding the AFHS and 4Ms before they were implemented.Methods: This study was a questionnaire-based survey of 252 healthcare professionals in geriatrics and long-term care departments, Rumailah Hospital, Acute Care Services in Hamad General Hospital, and home healthcare services to assess their perceptions, attitudes, and behaviors regarding 4Ms from November 1, 2022, to July 31, 2023.Results: Most respondents acknowledged the benefits of providing care through AFHS. However, only 62% of respondents reported using the 4Ms framework. The most commonly used types of age-friendly care provided by health care professionals were reviews of high-risk medication use (64.2%) and screening for mobility limitations (55.8%).Conclusion: The findings suggest that there is a need for more training and education regarding the 4Ms framework for health care providers. This training should focus on specific aspects of the framework, such as how to assess what matters most to older adults; how to manage their mobility, mentation, and medication; and how to coordinate care across settings.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"27 1","pages":"2401161"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0