Aging Male最新文献_第3页

Narrative-based sexual medicine. A collection of patients' stories and clinical cases to better understand the management of erectile dysfunction with type 5 phosphodiesterase inhibitors in the real life. 基于叙事的性医学。收集患者的故事和临床病例，以更好地了解现实生活中使用5型磷酸二酯酶抑制剂治疗勃起功能障碍的方法。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-04-02 DOI: 10.1080/13685538.2026.2652123

Andrea Sansone, Raffaella Mantegazza, Shivani Ohri Vignesh, Emmanuele A Jannini

{"title":"Narrative-based sexual medicine. A collection of patients' stories and clinical cases to better understand the management of erectile dysfunction with type 5 phosphodiesterase inhibitors in the real life.","authors":"Andrea Sansone, Raffaella Mantegazza, Shivani Ohri Vignesh, Emmanuele A Jannini","doi":"10.1080/13685538.2026.2652123","DOIUrl":"10.1080/13685538.2026.2652123","url":null,"abstract":"Introduction: Narrative-based medicine (NBM) integrates patient stories with the clinician's perspective and scientific evidence to personalize care. This approach is particularly well suited to sexual medicine. Sexual dysfunctions - especially erectile dysfunction (ED) - are highly multifaceted conditions in which individual histories and couple dynamics substantially influence diagnosis and treatment. Traditional evidence-based tools may fail to capture this complexity, as sexual symptoms emerge from the interplay of several connected systems. .Findings: This narrative review presents a series of realistic clinical vignettes illustrating the challenges of ED management within contemporary Italian sexual medicine, using the multidisciplinary Italian Society of Andrology and Sexual Medicine (SIAMS) guidelines as a normative framework. Each vignette is accompanied by scientific commentary grounded on evidence provided by the SIAMS guidelines. ED is framed as a sentinel symptom of systemic health, as postulated by the Systems Sexology which offer integrative models connecting the prescription of virtuous lifestyles with the type 5 phosphodiesterase inhibitors (PDE5i).Conclusion: This perspective underscores the inadequacy of simplistic \"symptom-pill\" approaches and highlights the need for personalized, multidimensional care, including alternative pharmaceutical formulations of PDE5i, such as the orodispersible film, that may enhance discretion, acceptability, and adherence.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2652123"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The reduction in total motile sperm count and the increase in sperm DNA fragmentation are associated with paternal age in normozoospermic men. 在正常精子男性中，活动精子总数的减少和精子DNA片段化的增加与父亲的年龄有关。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-01-10 DOI: 10.1080/13685538.2026.2612794

Chia-Min Liu, Hsing-Yi Chen, Hsiu-Chiung Hou, Jen-Hao Kuo, Tsung-Yen Lin, Yung-Ming Lin, Meng-Hsing Wu, Yu-Sheng Cheng

{"title":"The reduction in total motile sperm count and the increase in sperm DNA fragmentation are associated with paternal age in normozoospermic men.","authors":"Chia-Min Liu, Hsing-Yi Chen, Hsiu-Chiung Hou, Jen-Hao Kuo, Tsung-Yen Lin, Yung-Ming Lin, Meng-Hsing Wu, Yu-Sheng Cheng","doi":"10.1080/13685538.2026.2612794","DOIUrl":"10.1080/13685538.2026.2612794","url":null,"abstract":"Background: Normozoospermia does not guarantee fertility. Sperm DNA fragmentation (SDF) reflects intrinsic sperm quality and adverse reproductive outcomes, and double-strand breaks (DSBs) indicate more severe DNA damage.Methods: From July 2021 to February 2025, semen parameters, total motile sperm count (TMSC), and SDF from 534 normozoospermic men at National Cheng Kung University Hospital were retrospectively analyzed. Total DNA fragmentation (Total DFI) was measured using the sperm chromatin dispersion (SCD) test, and DSB DFI was assessed using the SDF Releasing (SDFR) assay.Results: Paternal age correlated negatively with ejaculatory volume (ρ = -0.214, p < 0.001), progressive motility (ρ = -0.184, p < 0.001), and TMSC (ρ = -0.118, p = 0.003), but positively with total DFI (ρ = 0.186, p = 0.025). Although Total DFI did not differ significantly across the three age groups (p = 0.081), men ≥ 40 years had higher Total DFI than those < 40 years (p = 0.032). DSB DFI showed no difference. Total DFI correlated with DSB DFI (ρ = 0.298, p = 0.005). Oligoasthenoteratozoospermic men exhibited higher total DFI than normozoospermic men (p = 0.048).Conclusion: Advancing paternal age is associated with reduced semen quality and increased sperm DNA fragmentation even among normozoospermic men.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2612794"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic relationships between the gut microbiota and prostate cancer: Mendelian randomization combined with bioinformatics analysis. 肠道微生物群与前列腺癌之间的遗传关系：孟德尔随机化与生物信息学分析相结合。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-01-14 DOI: 10.1080/13685538.2026.2615561

Wenjie Li, Chen Li, Xing Li, Zhan Gao

{"title":"Genetic relationships between the gut microbiota and prostate cancer: Mendelian randomization combined with bioinformatics analysis.","authors":"Wenjie Li, Chen Li, Xing Li, Zhan Gao","doi":"10.1080/13685538.2026.2615561","DOIUrl":"10.1080/13685538.2026.2615561","url":null,"abstract":"Background: Prostate cancer (PCa) is a leading cause of male cancer-related death globally. While the gut microbiota is linked to PCa, its genetic association remains unclear.Methods: We screened genetic instruments related to the gut microbiota and paired them with PCa genome-wide association study data to conduct Mendelian randomization (MR) analysis. Positive MR findings were then subjected to colocalization analysis. Subsequently, we utilized the Gene Expression Omnibus (GEO) dataset to perform differential expression analysis, aiming to identify differentially expressed associated genes (DEAGs). We determined the importance scores of these DEAGs through four machine learning models and constructed a nomogram based on these findings, and then validated it in another group of the GEO dataset.Results: MR analysis found 16 gut bacteria causally linked to PCa (7 risk, 9 protective), with 144 related genes. PLCL1, VSNL1, ROR2, NRXN3, and TEAD1 were identified as feature genes for constructing a nomogram that provides a quantitative prediction of the risk of PCa onset.Conclusions: This study indicates that there are causal links between the gut microbiota and PCa. Feature genes may affect the occurrence of PCa by inhibiting the epithelial-mesenchymal transition, proliferation, migration, and invasion of cells.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2615561"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between allostatic load and long-term survival in populations with high or low PSA levels: a national population-based analysis from NHANES 2003-2010. 高或低PSA水平人群的适应负荷与长期生存之间的关系：NHANES 2003-2010的一项基于全国人群的分析

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-02-08 DOI: 10.1080/13685538.2026.2625508

Yu Liu, Xingzhao Tian, Kun Zhu, Zheng Liu, Zhugang Long, Keyu Hou, Yujiao Zhou, Yaodong You, Degui Chang

{"title":"Association between allostatic load and long-term survival in populations with high or low PSA levels: a national population-based analysis from NHANES 2003-2010.","authors":"Yu Liu, Xingzhao Tian, Kun Zhu, Zheng Liu, Zhugang Long, Keyu Hou, Yujiao Zhou, Yaodong You, Degui Chang","doi":"10.1080/13685538.2026.2625508","DOIUrl":"10.1080/13685538.2026.2625508","url":null,"abstract":"Background: The present study aims to investigate the associations between the allostatic load index (ALI), prostate-specific antigen (PSA) levels, and certain causes of death among the participants.Methods: Participants in this study were selected from the NHANES database (2003-2010) and linked to mortality files (the National Death Index, 2003-2010). Multivariate Cox proportional hazards models were used to analyze the effect of the allostatic load (AL) on PSA levels and all-cause mortality in participants.Results: This study found that an increase in ALI exerted a certain impact on PSA levels in the entire participant population (especially in the subgroup with WWI < 0.5). Participants in the third quartile (T3) with the highest ALI index had a significantly 52% increased probability of all-cause mortality compared to those in T1 (OR = 1.52, 95% CI: 1.28, 1.76, P < 0.01). Both RCS analysis and the K-M curve provide corroboration. When treated as a continuous variable, it is also associated with cardiac mortality (OR = 1.14, 95% CI: 1.04, 1.26, P < 0.01).Conclusions: In a specific range, higher ALI was significantly and positively associated with PSA levels, all-cause mortality, and cardiovascular disease risk, though its link to cancer-specific mortality risk was not statistically significant in this study.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2625508"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between age and mortality in men with adult-onset testosterone deficiency is altered by testosterone therapy. 睾酮治疗改变了成年期睾酮缺乏症患者的年龄与死亡率之间的关系。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-07-02 DOI: 10.1080/13685538.2026.2696061

Amar Mann, Richard C Strange, Carola S König, Geoffrey Hackett, Ahmad Haider, Karim Sultan Haider, Peter Desnerck, Michael Zitzmann, Farid Saad, Mruga M Dhebar, John Marriott, Sudarshan Ramachandran

{"title":"The association between age and mortality in men with adult-onset testosterone deficiency is altered by testosterone therapy.","authors":"Amar Mann, Richard C Strange, Carola S König, Geoffrey Hackett, Ahmad Haider, Karim Sultan Haider, Peter Desnerck, Michael Zitzmann, Farid Saad, Mruga M Dhebar, John Marriott, Sudarshan Ramachandran","doi":"10.1080/13685538.2026.2696061","DOIUrl":"https://doi.org/10.1080/13685538.2026.2696061","url":null,"abstract":"Background: Using the Gompertz-Makeham model, we describe associations between age and the probability of mortality in men with adult-onset testosterone deficiency (TD), stratified by testosterone undecanoate (TU) treatment and type 2 diabetes (T2DM).Methods: We analyzed a registry of 737 men (353 and 384 men on/not on TU, respectively) with adult-onset TD with nearly 9 years of follow-up. We compared associations between age and mortality using nonparametric and logistic regression models (estimating individual mortality probability) in men stratified by TU treatment and T2DM.Results: Mortality was lower (p < 0.001) in men on TU compared to men opting against TU. In the men on TU, age was associated with mortality (odds ratio (OR): 1.26, 95% confidence interval (CI): 1.13-1.40) in the nonlinear pattern expected in the Gompertz‒Makeham model. However, age was not associated with mortality in men not on TU (OR: 1.03, 95% CI: 0.98-1.08). T2DM status did not affect these associations.Conclusion: The association between age and mortality differed between men on TU and those opting against treatment. In untreated men, features of metabolic syndrome worsened, which perhaps minimized the relationship between age and mortality. In men on TU, these metabolic risk factors improved, perhaps restoring the association between age and mortality.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2696061"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation analysis of metabolically healthy obesity and erectile dysfunction: a cross-sectional study based on the NHANES database (2001-2004). 代谢健康肥胖与勃起功能障碍的相关性分析：基于NHANES数据库的横断面研究（2001-2004）。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-07-31 DOI: 10.1080/13685538.2026.2712119

Yuchao Hou, Guangcai Yu, Chengyu Zhang, Jinhui Liu, Rui Li, Benzheng Zhou, Hengfeng Zhou

{"title":"Correlation analysis of metabolically healthy obesity and erectile dysfunction: a cross-sectional study based on the NHANES database (2001-2004).","authors":"Yuchao Hou, Guangcai Yu, Chengyu Zhang, Jinhui Liu, Rui Li, Benzheng Zhou, Hengfeng Zhou","doi":"10.1080/13685538.2026.2712119","DOIUrl":"https://doi.org/10.1080/13685538.2026.2712119","url":null,"abstract":"Objective: To explore the relationship between metabolically healthy obesity (MHO) and erectile dysfunction (ED).Methods: Using National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2004, 974 participants were classified into ED and non-ED groups. MHO diagnosis combined BMI-based obesity assessment with metabolic status evaluation per National Cholesterol Education Program-Adult Treatment Panel III (ATP III) criteria. Weighted univariate and multivariate logistic regression models assessed the association between obesity subtypes and ED. Subgroup analyzes examined association stability across populations. Two-sample Mendelian randomization (MR) evaluated causal relationships between individual metabolic syndrome criteria and ED occurrence.Results: In the optimized model, MHO was not associated with significantly increased ED risk compared to non-obese individuals. Metabolically abnormal obesity was associated with a 13% higher ED risk versus non-obese individuals (OR = 1.13, 95% CI: 1.02-1.25, p = 0.019). Subgroup analyzes showed no significant effect modification across subgroups (p > 0.05). Combined BMI and metabolic indicators demonstrated stronger predictive ability for ED than BMI alone, with waist circumference showing the strongest individual correlation (p = 0.001).Conclusion: MHO does not confer elevated ED risk. Metabolically abnormal obesity is associated with a 14% increased ED risk compared to non-obese individuals.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2712119"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frailty and frailty progression in relation to the risk of benign prostatic hyperplasia/lower urinary tract symptoms among Chinese middle-aged and older men: a prospective cohort study. 中国中老年男性衰弱和衰弱进展与良性前列腺增生/下尿路症状的风险相关：一项前瞻性队列研究

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-07 DOI: 10.1080/13685538.2026.2641911

Liangliang Li, Antao Dong, Kun Liu, Yameng Wu, Yiming Gong

{"title":"Frailty and frailty progression in relation to the risk of benign prostatic hyperplasia/lower urinary tract symptoms among Chinese middle-aged and older men: a prospective cohort study.","authors":"Liangliang Li, Antao Dong, Kun Liu, Yameng Wu, Yiming Gong","doi":"10.1080/13685538.2026.2641911","DOIUrl":"10.1080/13685538.2026.2641911","url":null,"abstract":"Background: Frailty and benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) are age-related conditions, but their longitudinal relationship remains unclear. This study investigated associations between frailty index (FI) trajectories, baseline frailty status, and incident BPH/LUTS in Chinese middle-aged and older men.Methods: Data from three waves (2011-2015) of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Group-based trajectory modeling identified FI trajectories. Multivariable logistic regression examined associations of baseline frailty status (robust, prefrail, frail) and FI trajectories with incident BPH/LUTS. Incremental predictive value of trajectories beyond baseline status was quantified using net reclassification improvement (NRI) and integrated discrimination improvement (IDI).Results: Among 4,449 men, four distinct FI trajectories were identified. Compared to the Persistently Low trajectory, Moderately Increasing and High-Increasing trajectories showed significantly higher BPH/LUTS risk (ORs: 2.01 [1.38-2.99] and 2.82 [1.79-4.45]; p-trend < 0.001). Baseline prefrail and frail status were also associated with elevated risk (ORs: 1.47 [1.13-1.90] and 1.67 [1.10-2.49], respectively). Dynamic frailty trajectories demonstrated improved risk reclassification over baseline assessment alone (continuous NRI: 0.284, p < 0.001; IDI: 0.011, p = 0.001).Conclusions: Both baseline frailty status and dynamic FI trajectories were independently associated with BPH/LUTS risk. Longitudinal trajectories exhibited stronger associations and greater predictive value, highlighting the importance of monitoring frailty progression for improved risk stratification and targeted prevention.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2641911"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-27 DOI: 10.1080/13685538.2026.2650003

Xin Zhang, Chuanlin Wang, Sen Pan, Wei Sun

{"title":"Age-related patterns in prostate cancer: epidemiology, pathology, treatment, and survival.","authors":"Xin Zhang, Chuanlin Wang, Sen Pan, Wei Sun","doi":"10.1080/13685538.2026.2650003","DOIUrl":"10.1080/13685538.2026.2650003","url":null,"abstract":"Background: Contemporary, systematic comparisons of prostate cancer (PCa) across the entire age spectrum regarding incidence, pathology, treatment, and long-term outcomes remain lacking.Methods: Patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database to assess age-related differences in pathological features, treatment patterns, and cancer-specific survival (CSS), with additional analyses accounting for competing risks from other-cause mortality.Results: Older age was associated with lower stage risk but higher PSA, ISUP grade, and overall disease risk (20-55 as reference; 56-65, OR = 1.29, 95% CI, 1.27-1.32, p < 0.001; 66-75, OR = 1.67, 95% CI, 1.64-1.71, p < 0.001; 76-85, OR = 3.10, 95% CI, 3.03-3.18, p < 0.001). In nonmetastatic patients, the likelihood of receiving definitive treatment and choosing radical prostatectomy decreases with age. Overall, CSS worsened with age; however, the 56-65 years group showed no significant difference compared with the 20-55 years reference group (HR = 1.00, 95% CI, 0.95-1.06, p = 0.872), whereas the older age groups presented progressively poorer CSS (66-75, HR = 1.16, 95% CI, 1.10-1.23, p < 0.001; 76-85, HR = 1.72, 95% CI, 1.62-1.82, p < 0.001). After accounting for other-cause mortality using a competing-risk model, similar patterns were observed.Conclusion: PCa is increasingly diagnosed in older men, with higher age associated with earlier-stage presentation but more adverse pathology, less frequent radical prostatectomy, and risk-dependent survival effects across age groups.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2650003"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systems biology approach to identify common molecular signatures in Hashimoto's thyroiditis and rheumatoid arthritis. 系统生物学方法识别桥本甲状腺炎和类风湿性关节炎的共同分子特征。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-27 DOI: 10.1080/13685538.2026.2650005

Jian-Bin Wei, Yuan Lin, Qing-Ying Xu, Lu-Ping Lin

{"title":"A systems biology approach to identify common molecular signatures in Hashimoto's thyroiditis and rheumatoid arthritis.","authors":"Jian-Bin Wei, Yuan Lin, Qing-Ying Xu, Lu-Ping Lin","doi":"10.1080/13685538.2026.2650005","DOIUrl":"10.1080/13685538.2026.2650005","url":null,"abstract":"Background: Hashimoto's thyroiditis (HT) and rheumatoid arthritis (RA) are prevalent autoimmune disorders with substantial clinical overlap, yet the shared molecular mechanisms underlying their comorbidity remain poorly understood.Materials and methods: Publicly available GEO datasets were analyzed to identify differentially expressed genes (DEGs) and hub genes. Functional enrichment analysis was performed to characterize biological processes associated with these DEGs. Single-sample gene set enrichment analysis (ssGSEA) was applied to assess immune cell infiltration patterns. A transcription factor‑mRNA‑microRNA (TF-mRNA-miRNA) regulatory network was constructed to pinpoint key regulators, and drug target prediction was conducted via the QuartataWeb platform.Results: Bioinformatics analysis of the GEO dataset identified 196 DEGs, including 10 hub genes. Enrichment analyses linked the DEGs to pathways involved in inflammation and immune regulation. ssGSEA revealed that activated B cells play a central role in disease pathogenesis. The regulatory network identified multiple critical modulators, and drug target analysis computationally predicted CD2, CTLA4, and CD27 as potential therapeutic targets.Conclusion: Our study findings suggest that the disruption of immune tolerance and aberrant immune activation are likely the primary mechanisms driving the comorbidity of HT and RA. The identified hub genes and their potential druggable targets provide a theoretical basis for subsequent experimental validation and the development of precision therapeutic strategies.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2650005"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the causal links among immune cell characteristics and prostatitis: a bidirectional two-sample Mendelian randomization study. 探讨免疫细胞特征与前列腺炎之间的因果关系：一项双向双样本孟德尔随机研究。

IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-30 DOI: 10.1080/13685538.2026.2650011

Yi Wang, Cong Xue, Zhuxian Xu, Bingye Zhu, Qianwei Xing

{"title":"Exploring the causal links among immune cell characteristics and prostatitis: a bidirectional two-sample Mendelian randomization study.","authors":"Yi Wang, Cong Xue, Zhuxian Xu, Bingye Zhu, Qianwei Xing","doi":"10.1080/13685538.2026.2650011","DOIUrl":"10.1080/13685538.2026.2650011","url":null,"abstract":"Purpose: We aimed to conduct a bidirectional two-sample Mendelian randomization (MR) analysis to comprehensively explore the causal associations between prostatitis and 731 immune cell properties.Methods: A bidirectional two-sample MR analysis was conducted to reveal their causal correlations. Sensitivity analyses were performed to assess the robustness of the results.Results: A total of 12 immune cells were found to be significantly linked with prostatitis risks, including CD39+ secreting Treg AC, B cell AC, NK %CD3- lymphocyte, CD28+ CD45RA- CD8dim %T cell, CD3 on CM CD4+ , CD3 on CD45RA- CD4+ , CD3 on CD39+ secreting Treg, CD3 on CD28+ CD4+ , CD3 on CD28+ CD45RA- CD8br, CD3 on CD28+ CD45RA+ CD8br, PDL-1 on CD14- CD16-, and CD4 on CD39+ secreting Treg (all FDRs < 0.05). Prostatitis was also found to be significantly linked with 11 immunophenotypes, containing CD25 on IgD+ CD38- unsw mem, CD38 on CD3- CD19-, CD3 on naive CD8br, CD3 on Naive CD4+ , CD3 on CD39+ CD4+ , CD3 on CD4+ , CD14 on CD14+ CD16- monocyte, CD4 on CM CD4+ , CD4 on naive CD4+ , CD4 on CD45RA+ CD4+ , and CD4 on secreting Treg (all FDRs < 0.05).Conclusions: Our results suggest important associations between prostatitis and immune cell profiles, shedding light on the immune-related etiologies and phenotypes in prostatitis.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2650011"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0