Correlation analysis of metabolically healthy obesity and erectile dysfunction: a cross-sectional study based on the NHANES database (2001-2004).

IF 3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-07-31 DOI:10.1080/13685538.2026.2712119

Yuchao Hou, Guangcai Yu, Chengyu Zhang, Jinhui Liu, Rui Li, Benzheng Zhou, Hengfeng Zhou

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引用次数: 0

Abstract

Objective: To explore the relationship between metabolically healthy obesity (MHO) and erectile dysfunction (ED).

Methods: Using National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2004, 974 participants were classified into ED and non-ED groups. MHO diagnosis combined BMI-based obesity assessment with metabolic status evaluation per National Cholesterol Education Program-Adult Treatment Panel III (ATP III) criteria. Weighted univariate and multivariate logistic regression models assessed the association between obesity subtypes and ED. Subgroup analyzes examined association stability across populations. Two-sample Mendelian randomization (MR) evaluated causal relationships between individual metabolic syndrome criteria and ED occurrence.

Results: In the optimized model, MHO was not associated with significantly increased ED risk compared to non-obese individuals. Metabolically abnormal obesity was associated with a 13% higher ED risk versus non-obese individuals (OR = 1.13, 95% CI: 1.02-1.25, p = 0.019). Subgroup analyzes showed no significant effect modification across subgroups (p > 0.05). Combined BMI and metabolic indicators demonstrated stronger predictive ability for ED than BMI alone, with waist circumference showing the strongest individual correlation (p = 0.001).

Conclusion: MHO does not confer elevated ED risk. Metabolically abnormal obesity is associated with a 14% increased ED risk compared to non-obese individuals.

查看原文本刊更多论文

代谢健康肥胖与勃起功能障碍的相关性分析：基于NHANES数据库的横断面研究（2001-2004）。

目的：探讨代谢健康型肥胖（MHO）与勃起功能障碍（ED）的关系。方法：利用2001 ~ 2004年全国健康与营养调查（NHANES）数据，将974名受试者分为ED组和非ED组。根据国家胆固醇教育计划-成人治疗小组III （ATP III）标准，MHO诊断结合了基于bmi的肥胖评估和代谢状态评估。加权单变量和多变量logistic回归模型评估了肥胖亚型与ED之间的关系。亚组分析检查了人群之间的关系稳定性。双样本孟德尔随机化（MR）评估了个体代谢综合征标准与ED发生之间的因果关系。结果：在优化的模型中，与非肥胖者相比，MHO与ED风险的显著增加无关。与非肥胖者相比，代谢异常肥胖与ED风险增加13%相关（OR = 1.13, 95% CI: 1.02-1.25, p = 0.019）。亚组分析显示各组间无显著差异（p < 0.05）。BMI与代谢指标的结合对ED的预测能力强于BMI，其中腰围的个体相关性最强（p = 0.001）。结论：MHO不会增加ED风险。与非肥胖者相比，代谢异常的肥胖与ED风险增加14%有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.