Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-01-08 DOI:10.1080/13685538.2024.2449341

Wentao Yao, Jiacheng Wu, Hongzhi Wang, Zongming Jia, Yinyi Zhou, Chendi Yang, Feng Xu, Ying Kong, Yuhua Huang

{"title":"Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study.","authors":"Wentao Yao, Jiacheng Wu, Hongzhi Wang, Zongming Jia, Yinyi Zhou, Chendi Yang, Feng Xu, Ying Kong, Yuhua Huang","doi":"10.1080/13685538.2024.2449341","DOIUrl":null,"url":null,"abstract":"Objectives: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.Methods: Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.Results: Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [-0.075 (-0.145, -0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [-0.282 (-0.557, -0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point.Conclusion: In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2449341"},"PeriodicalIF":2.7000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Male","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13685538.2024.2449341","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.

Methods: Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.

Results: Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [-0.075 (-0.145, -0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [-0.282 (-0.557, -0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point.

Conclusion: In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70.

查看原文本刊更多论文

40岁及以上男性内脏脂肪指数与前列腺癌之间的关系：一项全国性横断面研究。

目的：本研究旨在阐明美国40岁及以上男性的内脏脂肪指数（VAI）与前列腺癌（PCa）的相关性。方法：采用2003-2010年全国健康与营养调查（NHANES）数据进行多元线性和logistic回归分析、平滑曲线拟合和阈值效应评价。通过亚组分析和相互作用测试评估了人口统计学组间这种关系的稳定性。结果：在2768名参与者中，VAI升高的患者表现出较低的总前列腺特异性抗原（tPSA）水平和较低的PCa风险。每升高一个VAI单位，tPSA降低0.075 ng/mL[-0.075(-0.145, -0.005)]，前列腺癌风险降低18.8%[0.812(0.687,0.960)]。与最低四分位数的VAI个体相比，最高四分位数的VAI个体的tPSA降低了0.282 ng/mL [-0.282 (-0.557, -0.007)]， PCa风险降低了49.7%[0.503(0.282,0.896)]。这种负相关关系在≥70岁的男性中更为明显。其他种族的VAI-tPSA呈u型分布，拐点为2.09。与此同时，墨西哥裔美国人的VAI和PCa风险呈倒u型，拐点为1.42。结论：在≥70岁的男性中，VAI与PCa呈负相关。然而，基于psa的前列腺癌筛查可能会影响年龄较大的内脏肥胖个体

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.