Relationship of prolonged sit-to-stand test duration and cardiovascular disease risk in Middle-aged and older adults: evidence from CHARLS.

IF 2.6 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Aging Male Pub Date : 2025-12-01 Epub Date: 2025-07-18 DOI:10.1080/13685538.2025.2534558
Xiaofeng Zhang, Weili Li, Danchan Lu, Zhenhua Jin
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引用次数: 0

Abstract

Background: The 5-repetition sit-to-stand (5STS) test, a common physical performance measure, has been associated with various health outcomes, but its relationship with cardiovascular disease (CVD) risk warrants further investigation.

Objectives: This study examined the association between 5STS test duration and CVD risk in middle-aged and elderly Chinese adults.

Methods: Data were from the China Health and Retirement Longitudinal Study (CHARLS). Cross-sectional and longitudinal analyses using linear and logistic regression models assessed the relationship between 5STS duration and CVD risk. Subgroup analyses and restricted cubic spline models explored effect modifiers and non-linear trends.

Results: Longer 5STS duration was independently associated with higher CVD risk. Each additional second increased CVD odds (cross-sectional: OR = 1.03, 95% CI: 1.02-1.04; longitudinal: OR = 1.04, 95% CI: 1.02-1.06). A graded association was observed, with the highest quartile demonstrating approximately 1.5 times the risk compared to the lowest. Restricted cubic spline analysis indicated a steep risk increase at approximately 9.81 s.

Conclusions: The 5STS test is a potential non-invasive predictor of CVD risk and may be useful for early detection in clinical settings. Further research across diverse populations is needed.

中老年人坐立试验时间延长与心血管疾病风险的关系:来自CHARLS的证据
背景:5次坐立测试(5STS)是一种常见的体能测试,与多种健康结果相关,但其与心血管疾病(CVD)风险的关系值得进一步研究。目的:本研究探讨中国中老年成人5STS测试时间与CVD风险之间的关系。方法:数据来自中国健康与退休纵向研究(CHARLS)。使用线性和逻辑回归模型进行横断面和纵向分析,评估5STS持续时间与CVD风险之间的关系。亚群分析和限制三次样条模型探讨了效应修饰因子和非线性趋势。结果:5STS持续时间较长与CVD风险较高独立相关。每增加一秒心血管疾病的几率增加(横断面:OR = 1.03, 95% CI: 1.02-1.04;纵向:OR = 1.04, 95% CI: 1.02-1.06)。观察到分级关联,最高四分位数的风险约为最低四分位数的1.5倍。限制三次样条分析表明,风险急剧增加,约为9.81 s。结论:5STS试验是一种潜在的无创CVD风险预测指标,可用于临床环境中的早期检测。需要对不同人群进行进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Aging Male
Aging Male 医学-泌尿学与肾脏学
CiteScore
6.40
自引率
3.80%
发文量
33
审稿时长
>12 weeks
期刊介绍: The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.
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