The depressive effects of androgen deprivation therapy in locally advanced or metastatic prostate cancer: a comparative study.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2020-12-01 Epub Date: 2019-03-29 DOI:10.1080/13685538.2019.1586869

Yasin Ceylan, Bulent Gunlusoy, Asli Koskderelioglu, Muhtesem Gedizlioglu, Tansu Degirmenci

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引用次数: 12

Abstract

Aim: To investigate association of androgen deprivation therapy (ADT) with depression and the effect of depression on cognitive functions in men with locally advanced or metastatic prostate cancer.

Methods: A total of 144 patients were evaluated in a prospective, comparative study. Group1 consisted of 72 patients with locally advanced or metastatic prostate cancer who received complete ADT treatment continuously for 12 months and group2 (control group) consisted of 72 patients who underwent radical prostatectomy without any additional treatment. MoCA (The Montreal Cognitive Assessment) and HAM-D (Hamilton depression rating scale) tests were used to assess the effects of ADT on depression and cognitive functions.

Results: According to post-treatment results of MoCA test, patients had lower mean total scores in both the groups. The deficits were especially prominent in the areas of language ability and short-term memory capacity. In the comparison of two groups according to HAM-D tests, the scores were significantly higher in group1 at baseline-6 month, at baseline-12 month and at 6-12 month follow-up period (p = .003, p < .001, p = .023).There was a relationship between depression and deterioration of language and memory functions at 6th (p < .001, p = .002) and 12th months (p < .001, p = .046). Attention function was deteriorated in these patients at 6th (p < .001) and 12th months (p < .001).

Conclusions: ADT causes increase in depression and the deterioration of cognitive functions. ADT should be given carefully to these older group of patients with concomitant morbidities.

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雄激素剥夺治疗对局部晚期或转移性前列腺癌的抑制作用:一项比较研究。

目的:探讨雄激素剥夺治疗(ADT)与抑郁症的关系，以及抑郁症对局部晚期或转移性前列腺癌患者认知功能的影响。方法:对144例患者进行前瞻性比较研究。组1包括72例局部晚期或转移性前列腺癌患者，他们连续接受完整的ADT治疗12个月;组2(对照组)包括72例患者，他们接受根治性前列腺切除术，没有任何额外的治疗。采用MoCA(蒙特利尔认知评估)和HAM-D(汉密尔顿抑郁评定量表)测试评估ADT对抑郁和认知功能的影响。结果:治疗后MoCA测试结果显示，两组患者平均总分均较低。这种缺陷在语言能力和短期记忆能力方面尤为突出。根据HAM-D测试两组比较，1组在基线-6个月、基线-12个月和随访6-12个月时得分显著高于对照组(p =。003, p = .023)。在第6个月(p = 0.002)和第12个月(p = 0.046)抑郁与语言和记忆功能的恶化有关系。结论:ADT导致抑郁加重和认知功能恶化。对于这些伴有并发症的老年患者，应谨慎给予ADT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.