Aging Male最新文献_第8页

Liquid biopsy in prostate cancer: current status and future challenges of clinical application. 前列腺癌液体活检:临床应用现状及未来挑战。

IF 2.6 4区医学

Aging Male Pub Date : 2021-12-01 DOI: 10.1080/13685538.2021.1944085

Yaqiong Wang, Zili Wang, Xiaokun Gang, Guixia Wang

{"title":"Liquid biopsy in prostate cancer: current status and future challenges of clinical application.","authors":"Yaqiong Wang, Zili Wang, Xiaokun Gang, Guixia Wang","doi":"10.1080/13685538.2021.1944085","DOIUrl":"https://doi.org/10.1080/13685538.2021.1944085","url":null,"abstract":"Purpose: Liquid biopsy refers to the detection and analysis of the components from biological fluids non-invasively, including circulating tumor cells, nucleic acids, and extracellular vesicles (EVs). It is necessary to review the clinical value of liquid biopsy assays in PC and explore its potential application.Materials and methods: We systematically reviewed of PubMed was performed to identify relevant literature on potential clinical applications of circulating tumor cells, circulating nucleic acids, and EVs in prostate cancer (PC).Results: Liquid biopsy has emerged as a powerful tool to elucidate dynamic genomic, transcriptomic, and epigenomic tumor profiling in real-time. Here, the potential clinical applications of liquid biopsy include early detection, prognosis of survival, assessment of treatment response, and mechanisms of drug resistance in PC.Conclusions: Liquid biopsy provides great value in diagnosis, prognosis, and treatment response in PC. Characterization of liquid biopsy components provides benefits both to unravel underlying resistance mechanisms and to exploit novel clinically actionable targets in PC. In addition, we suggest that analysis of multiparametric liquid biopsies should be analyzed comprehensively, assisting in monitoring tumor characteristics in real-time, guiding therapeutic selection, and early therapeutic switching during disease progression.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"58-71"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Is the increased incidence of pathologically proven acute appendicitis more likely seen in elderly patients? A retrospective cohort study. 病理证实的急性阑尾炎发病率增加是否更容易在老年患者中看到?回顾性队列研究。

IF 2.6 4区医学

Aging Male Pub Date : 2021-12-01 DOI: 10.1080/13685538.2021.1911990

Abdullah Sisik, Ilyas Kudas, Fatih Basak, Mustafa Hasbahceci

{"title":"Is the increased incidence of pathologically proven acute appendicitis more likely seen in elderly patients? A retrospective cohort study.","authors":"Abdullah Sisik, Ilyas Kudas, Fatih Basak, Mustafa Hasbahceci","doi":"10.1080/13685538.2021.1911990","DOIUrl":"https://doi.org/10.1080/13685538.2021.1911990","url":null,"abstract":"Aim: Although appendicitis is a disease of the young, it has been speculated that its incidence has increased among the elderly people. In this study, it was aimed to evaluate annual changes of appendicitis seen in older patients (≥60 years) throughout a 10-year period.Methods: All adult patients who were surgically treated for acute appendicitis were retrospectively analyzed with respect to pathological analysis, gender, age and proportion of the patients aged 60 or over in an annual base. Variability in the mean age and proportion of the older patients aged 60 or over throughout the study years were regarded as the main outcomes.Results: There were 3296 patients with a mean age of 30.42 ± 12 years. Distribution of gender was similar (p = 0.636). There was a significant positive correlation in the mean age of the patients throughout the study years (p = 0.043). Stratification by the age of 60 yielded a significant increase in percent of the older patients, from 0.93% at 2007 to 4.28% at 2016 (p = 0.019).Conclusions: The mean age of the patients with acute appendicitis is going to increase. Therefore, it is expected that all surgeons are more likely to be confronted with elderly patients with appendicitis in the near-future.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2021.1911990","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38824928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prognosis of primary or metachronous prostate cancer in multiple primary genitourinary cancers; a single center experience with long-term results. 原发性或异时性前列腺癌在多发性原发性泌尿生殖系统癌中的预后一个具有长期效果的单一中心体验。

IF 2.6 4区医学

Aging Male Pub Date : 2021-12-01 DOI: 10.1080/13685538.2020.1817368

Caner Ediz, Serkan Akan, Hasan Huseyin Tavukcu, Muhammed Esad Kayhan, Omer Yilmaz

{"title":"Prognosis of primary or metachronous prostate cancer in multiple primary genitourinary cancers; a single center experience with long-term results.","authors":"Caner Ediz, Serkan Akan, Hasan Huseyin Tavukcu, Muhammed Esad Kayhan, Omer Yilmaz","doi":"10.1080/13685538.2020.1817368","DOIUrl":"https://doi.org/10.1080/13685538.2020.1817368","url":null,"abstract":"Objective: This study aims to analyze the challenges, approaches and long-term results of primary or metachronous prostate cancer (PCa) in cases with multiple primary genitourinary cancers.Methodology: A total of 17 patients were included in the study. Patients with multiple primary genitourinary cancers were divided into two groups according to the diagnosis of primary or metachronous PCa as group 1 and group 2.Results: The median age of patients was similar in both groups. The median smoking status (pack-years) was higher in group 2 than group 1. The median prostate-specific antigen (PSA) level was higher in group 1 than group 2. The median follow-up time from primary to the metachronous tumour was higher in group 1 than group 2. The rate of recurrence in PCa was higher in group 1 than group 2. No statistically significant difference was observed in terms of patients' age, smoking status, PSA levels at diagnosis of PCa and biochemical recurrence or metastasis between the two groups (p > 0.05).Conclusion: Primary PCa cases may progress more aggressively than metachronous PCa cases. Biochemical recurrence and metastasis may be less threatening in metachronous PCa cases than primary cases. Therefore, aggressive treatment can be avoided for metachronous PCa cases.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"37-41"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39267660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Holmium laser enucleation versus bipolar transurethral enucleation for treating benign prostatic hyperplasia, which one is better? 钬激光去核与双极经尿道去核治疗良性前列腺增生，哪个更好?

IF 2.6 4区医学

Aging Male Pub Date : 2021-12-01 DOI: 10.1080/13685538.2021.2014807

Jinze Li, Dehong Cao, Yin Huang, Chunyang Meng, Lei Peng, Zhongyou Xia, Yunxiang Li, Qiang Wei

{"title":"Holmium laser enucleation versus bipolar transurethral enucleation for treating benign prostatic hyperplasia, which one is better?","authors":"Jinze Li, Dehong Cao, Yin Huang, Chunyang Meng, Lei Peng, Zhongyou Xia, Yunxiang Li, Qiang Wei","doi":"10.1080/13685538.2021.2014807","DOIUrl":"https://doi.org/10.1080/13685538.2021.2014807","url":null,"abstract":"Objective: This study aims to evaluate the overall efficacy and safety between holmium laser enucleation of the prostate (HoLEP) and bipolar transurethral enucleation of the prostate (B-TUEP) for the treatment of benign prostatic hyperplasia (BPH).Method: We systematically searched electronic databases (PubMed, Scopus, Web of Science, and Cochrane Library) to identify eligible comparative studies as of July 2021. The parameters including perioperative results, complications, and functional outcomes were evaluated. RevMan version 5.4 was used for the analysis.Results: A total of 10 studies involving 1725 patients were included. HoLEP had lower operative time (p = .03), shorter catheterization time (p = .007), lower bladder irrigation time (p = .01), and higher enucleation weight (p = .01) compared with B-TUEP. However, there were no significant differences between the techniques regarding the length of stay (LOS), hemoglobin drop, transfusion rates, and complications. Furthermore, no significant differences were also observed in postoperative functional outcomes at 1, 3, 6, 12, or 24 months.Conclusions: HoLEP has more advantages in perioperative parameters compared with B-TUEP, but no significant differences are found regarding functional outcomes and complications. Large-scale studies with long-term follow-up are required to compare the outcomes of these two techniques.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"24 1","pages":"160-170"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39715268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparing clinical parameters of abnormal and normal fasting blood glucose in benign prostatic hyperplasia patients. 良性前列腺增生患者空腹血糖异常与正常的临床参数比较。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2019-02-10 DOI: 10.1080/13685538.2019.1570493

Ming-Juan Zhao, Qiao Huang, Xing-Huan Wang, Xuan-Yi Ren, Ying-Hui Jin, Xian-Tao Zeng

{"title":"Comparing clinical parameters of abnormal and normal fasting blood glucose in benign prostatic hyperplasia patients.","authors":"Ming-Juan Zhao, Qiao Huang, Xing-Huan Wang, Xuan-Yi Ren, Ying-Hui Jin, Xian-Tao Zeng","doi":"10.1080/13685538.2019.1570493","DOIUrl":"https://doi.org/10.1080/13685538.2019.1570493","url":null,"abstract":"Objective: To investigate the correlation of clinical measurements on normal and abnormal fasting blood glucose (FBG) with benign prostatic hyperplasia (BPH).Methods: From September 2016 to January 2018, 771 BPH patients were enrolled for further selection. The eligible patients were divided into normal FBG, impaired fasting glucose (IFG), and high risk of type 2 diabetes mellitus (HR-T2DM) groups. Then, relevant parameters were compared among these three groups using Pearson's correlation coefficient.Results: Finally including 443 patients with normal FBG, 113 with IFG and 56 with HR-T2DM. Height, weight, body mass index, smoking status, hemoglobin, serum Na+, serum Cl-, and serum Ca2+ were significantly different between normal and abnormal FBG groups. In IFG/HR-T2DM group, obviously connections were demonstrated for weight with prostate volume (PV), for serum Na+, PV, and serum Cl- with total prostate-specific antigen (t-PSA), for FBG with international prostate symptom score (IPSS). In normal FBG group, significant correlations of age, weight, body mass index, hemoglobin, and serum Ca2+ with PV, of age, systolic blood pressure, PV, and serum Cl- with t-PSA; and of FBG, hemoglobin, and serum Na+ with IPSS were also observed.Conclusions: Our study suggests that FBG level probably plays an important role in BPH.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"655-662"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1570493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36948395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The depressive effects of androgen deprivation therapy in locally advanced or metastatic prostate cancer: a comparative study. 雄激素剥夺治疗对局部晚期或转移性前列腺癌的抑制作用:一项比较研究。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2019-03-29 DOI: 10.1080/13685538.2019.1586869

Yasin Ceylan, Bulent Gunlusoy, Asli Koskderelioglu, Muhtesem Gedizlioglu, Tansu Degirmenci

{"title":"The depressive effects of androgen deprivation therapy in locally advanced or metastatic prostate cancer: a comparative study.","authors":"Yasin Ceylan, Bulent Gunlusoy, Asli Koskderelioglu, Muhtesem Gedizlioglu, Tansu Degirmenci","doi":"10.1080/13685538.2019.1586869","DOIUrl":"https://doi.org/10.1080/13685538.2019.1586869","url":null,"abstract":"Aim: To investigate association of androgen deprivation therapy (ADT) with depression and the effect of depression on cognitive functions in men with locally advanced or metastatic prostate cancer.Methods: A total of 144 patients were evaluated in a prospective, comparative study. Group1 consisted of 72 patients with locally advanced or metastatic prostate cancer who received complete ADT treatment continuously for 12 months and group2 (control group) consisted of 72 patients who underwent radical prostatectomy without any additional treatment. MoCA (The Montreal Cognitive Assessment) and HAM-D (Hamilton depression rating scale) tests were used to assess the effects of ADT on depression and cognitive functions.Results: According to post-treatment results of MoCA test, patients had lower mean total scores in both the groups. The deficits were especially prominent in the areas of language ability and short-term memory capacity. In the comparison of two groups according to HAM-D tests, the scores were significantly higher in group1 at baseline-6 month, at baseline-12 month and at 6-12 month follow-up period (p = .003, p < .001, p = .023).There was a relationship between depression and deterioration of language and memory functions at 6th (p < .001, p = .002) and 12th months (p < .001, p = .046). Attention function was deteriorated in these patients at 6th (p < .001) and 12th months (p < .001).Conclusions: ADT causes increase in depression and the deterioration of cognitive functions. ADT should be given carefully to these older group of patients with concomitant morbidities.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"733-739"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2019.1586869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37101709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Andropause symptoms and sickness absence in Japanese male workers: a prospective study. 日本男性工人的男性更年期症状和疾病缺勤:一项前瞻性研究。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2020-12-21 DOI: 10.1080/13685538.2020.1862078

Kumi Hirokawa, Yasuhito Fujii, Toshiyo Taniguchi, Jiro Takaki, Akizumi Tsutsumi

{"title":"Andropause symptoms and sickness absence in Japanese male workers: a prospective study.","authors":"Kumi Hirokawa, Yasuhito Fujii, Toshiyo Taniguchi, Jiro Takaki, Akizumi Tsutsumi","doi":"10.1080/13685538.2020.1862078","DOIUrl":"https://doi.org/10.1080/13685538.2020.1862078","url":null,"abstract":"Objective: The purpose of the study was to investigate the association between andropause symptoms and sickness absence in Japanese male workers over 2 years.Methods: A baseline survey asking about andropause symptoms, along with blood sampling for testosterone level, was conducted in June 2009. A total of 418 men (mean age = 52.4 years, SD = 8.6) participated and were followed through 2011. Hazard ratios (HRs) and 95% confidence intervals (CIs) for sickness absence were calculated using Cox proportional hazard models.Results: During the follow-up period, 31 of 35 participants who took sickness absences had physical illnesses. A higher andropause symptom score was associated with an increased risk of sickness absence. Testosterone deficiency (<350 ng/dL) was not associated with sickness absence. Among the subscales of andropause symptoms, the somatic symptom score was positively associated with sickness absence, whereas testosterone deficiency combined with high sexual symptoms was not associated with sickness absence. Results were similar when limited to sickness absence because of physical illness. No significant interaction between andropause symptoms and testosterone deficiency was found.Conclusions: Non-specific andropause symptoms unrelated to testosterone deficiency were positively associated with sickness absence.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1545-1552"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1862078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38733423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can myocardial performance index predict early cardiac risks in erectile dysfunction? 心肌功能指数能否预测勃起功能障碍患者的早期心脏风险?

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2020-05-20 DOI: 10.1080/13685538.2020.1768367

İsa Ardahanlı, Mehmet Celik

{"title":"Can myocardial performance index predict early cardiac risks in erectile dysfunction?","authors":"İsa Ardahanlı, Mehmet Celik","doi":"10.1080/13685538.2020.1768367","DOIUrl":"https://doi.org/10.1080/13685538.2020.1768367","url":null,"abstract":"Aim: Myocardial performance index (MPI) is an easy-to-apply and non-invasive method that shows both systolic and diastolic functions of the heart. In this study, it was aimed to evaluate the relationship between erectile dysfunction (ED) and MPI. Methods: The study included 45 male patients admitted to the urology outpatient clinic for ED and 48 healthy male volunteers. Echocardiographic evaluation of all participants was performed. Isovolumetric contraction time (IVCT), isovolumetric relaxation time (IVRT) and ejection time (ET) were measured. MPI was calculated using the IVCT + IVRT/ET formula. Results: The average age of the study population was 50 ± 5.3. Early diastolic mitral inflow (E)/late diastolic mitral inflow (A) ratio was significantly lower in the ED group (p ≤ 0.05). In the TDI evaluation between the groups, while early diastolic mitral annular velocity (Em) was significantly higher in the ED group, there was no significant difference in late diastolic mitral annular velocity (Am) and systolic peak velocities (Sm) (p < 0.01 and p = 0.417 and p = 0.092, respectively). While IVRT was significantly lower in the ED group (p < 0.05), there was no significant difference in IVCT and ET (p = 311 and p = 0.261, respectively). MPI was statistically significantly higher in the ED group (p < 0.05). Conclusion: ED has been found to affect MPI. This parameter, which is easily and non-invasively measured, can be used to predict the risk of CVDs in ED.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1355-1361"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1768367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37953471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Therapeutic potential of Mucuna pruriens (Linn.) on ageing induced damage in dorsal nerve of the penis and its implication on erectile function: an experimental study using albino rats. 瘙痒黏液(Linn.)对衰老引起的阴茎背神经损伤的治疗潜力及其对勃起功能的影响:一项白化大鼠实验研究。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2018-02-15 DOI: 10.1080/13685538.2018.1439005

Prakash Seppan, Ibrahim Muhammed, Karthik Ganesh Mohanraj, Ganesh Lakshmanan, Dinesh Premavathy, Sakthi Jothi Muthu, Khayinmi Wungmarong Shimray, Sathya Bharathy Sathyanathan

{"title":"Therapeutic potential of Mucuna pruriens (Linn.) on ageing induced damage in dorsal nerve of the penis and its implication on erectile function: an experimental study using albino rats.","authors":"Prakash Seppan, Ibrahim Muhammed, Karthik Ganesh Mohanraj, Ganesh Lakshmanan, Dinesh Premavathy, Sakthi Jothi Muthu, Khayinmi Wungmarong Shimray, Sathya Bharathy Sathyanathan","doi":"10.1080/13685538.2018.1439005","DOIUrl":"https://doi.org/10.1080/13685538.2018.1439005","url":null,"abstract":"Objective: To study the effect of ethanolic seed extract of Mucuna pruriens on damaged dorsal nerve of the penis (DNP) in aged rat in relation to penile erection.Methods: The rats were divided into four groups Young (3 months), Aged (24 - 28 months), Aged + M. pruriens, and Young + M. pruriens (200 mg/kg b.w/60 days) and were subjected to the hypophysial - gonadal axis, nerve conduction velocity (NCV), and penile reflex. DNP sections were stained with nitric oxide synthase (nNOS), nicotinamide adenine dinucleotide phosphate (NaDPH) diaphorase, androgen receptor (AR), and osmium tetroxide. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) staining, electron microscopy(EM) and histometric analyses were done.Results: Significant disturbance in hypophysial - gonadal axis was noted in aged rat. With reduced number of myelinated fibers, diameter, vacuolization, indentation of the myelin sheath, and degeneration. nNOS and its cofactor (NaDPH diaphorase) were reduced in aged rat DNP. NCV was slow in aged rats and concomitant poor penile reflex was also noted. AR showed reduced expression in aged rat DNP when compared to young and control groups. TUNEL positive cells were increased in aged rat DNP. These pathological changes were remarkably reduced or recovered in M. pruriens treated aged rats.Conclusions: The results indicate a multi-factorial therapeutic activity in penile innervations towards sustaining the penile erection in the presence of the extract in aged rats and justifying the claim of traditional usage.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"313-326"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2018.1439005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35834082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 103

Serum bicarbonate level improves specificity of Berlin Sleep Questionnaire for obstructive sleep apnea. 血清碳酸氢盐水平提高柏林睡眠问卷对阻塞性睡眠呼吸暂停的特异性。

IF 2.6 4区医学

Aging Male Pub Date : 2020-12-01 Epub Date: 2020-08-05 DOI: 10.1080/13685538.2020.1801623

Mazlum Dursun, Hadice Selimoğlu Şen, Süreyya Yılmaz, Melike Demir, Gökhan Kırbaş, Mahşuk Taylan

{"title":"Serum bicarbonate level improves specificity of Berlin Sleep Questionnaire for obstructive sleep apnea.","authors":"Mazlum Dursun, Hadice Selimoğlu Şen, Süreyya Yılmaz, Melike Demir, Gökhan Kırbaş, Mahşuk Taylan","doi":"10.1080/13685538.2020.1801623","DOIUrl":"https://doi.org/10.1080/13685538.2020.1801623","url":null,"abstract":"Several questionnaires have been developed to assist the diagnostic process in obstructive sleep apnea syndrome (OSAS). Berlin Sleep Questionnaire (BSQ) represents a validated screening tool for OSAS. Totally 450 patients admitted to the Sleep Center at Dicle University Medical Faculty were included prospectively. A risk analysis was performed for presence of OSAS using the BSQ. Arterial blood gas measurements were performed including bicarbonate (HCO3) level. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of BSQ for presence of OSAS and severe OSAS were determined. In patients with arterial HCO3 >24.94 mEq/L; sensitivity, specificity, PPV and NPV, of the BSQ were 93.04, 57.1, 98.3, and 23.5%, respectively. The addition of arterial HCO3 value increased the sensitivity of the BSQ in detecting OSAS patients. Although the cost of sleep studies is high for false positives from the BSQ plus arterial HCO3 level, this cost should be compared with the loss of work efficiency and severe healthcare costs of undiagnosed cases in the future. Therefore, finding possible OSAS cases in primary care health centers is important and adding serum HCO3 value to BSQ questionnaire may contribute to this topic.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"23 5","pages":"1480-1486"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13685538.2020.1801623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38229387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2