Vascular health of fathers with history of intracytoplasmic sperm injection.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI:10.1080/13685538.2024.2360529

Pengzhu Li, Magdalena Langer, Theresa Vilsmaier, Marie Kramer, Franziska Sciuk, Brenda Kolbinger, André Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer

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引用次数: 0

Abstract

Objective: Studies suggest that men who undergo assisted reproductive technologies (ART) may have a higher risk of cardiovascular disease; however, limited data on this matter is available. This observational pilot study aimed to investigate the overall vascular health of fathers with history of intracytoplasmic sperm injection (ICSI) compared to fathers whose partners conceived spontaneously.

Methods: Diet quality, physical activity, sedentary behavior as well as overall vascular function including the assessment of pulse wave analysis, intima-media thickness (cIMT), arterial stiffness of the common carotid artery (CCA) and blood lipids, were evaluated.

Results: A total of 34 fathers with history of ICSI and 29 controls (48.49 [46.32 - 57.09] years vs. 47.19 [40.62 - 55.18] years, p = 0.061) were included. After adjusting for age, no significantly increased cardiovascular risk was detected regarding vascular function.

Conclusions: The results suggest an unaltered cardiovascular risk profile in fathers with history of ICSI. In the future, prospective multicenter studies are required to validate these preliminary results.

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有过卵胞浆内单精子注射史的父亲的血管健康状况。

目的：研究表明，接受辅助生殖技术（ART）的男性罹患心血管疾病的风险可能较高；然而，这方面的数据却很有限。这项观察性试点研究旨在调查有卵胞浆内单精子显微注射（ICSI）史的父亲与伴侣自然受孕的父亲相比，他们的整体血管健康状况：方法：对饮食质量、体力活动、久坐行为以及整体血管功能（包括脉搏波分析评估、内膜中层厚度（cIMT）、颈总动脉（CCA）的动脉僵硬度和血脂）进行评估：共纳入了 34 名有 ICSI 病史的父亲和 29 名对照组父亲（48.49 [46.32 - 57.09] 岁 vs. 47.19 [40.62 - 55.18] 岁，p = 0.061）。对年龄进行调整后，未发现血管功能方面的心血管风险明显增加：结果表明，有 ICSI 史的父亲的心血管风险状况没有改变。未来需要进行前瞻性多中心研究来验证这些初步结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.