美国男性血清尿酸水平与良性前列腺增生的关系：2005年至2008年NHANES结果。

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2023-12-01 Epub Date: 2023-10-28 DOI:10.1080/13685538.2023.2275775

Hang Zhou, Mingming Xu, Xuexue Hao, Zhunan Xu, Yang Pan, Xiaoqiang Liu

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引用次数: 0

摘要

背景：尿酸（UA）与良性前列腺增生（BPH）之间的关系是有争议的，很少在美国人群中进行研究。方法：使用两个周期的国家健康和营养检查调查的数据，包括2005年至2008年的数据。大多数BPH是通过自我报告确定的。我们使用单变量和多变量逻辑回归分析来研究UA和BPH之间的关系。结果：2845名参与者参与了这项研究，其中531名参与者患有前列腺增生症，2314名为对照组。在对所有混杂因素进行充分调整后，每100例患者患前列腺增生的风险降低了18% UA增加μmol/L（OR=0.82，95%CI:0.69-0.97，p = 0.023）。与UA最低四分位数的参与者相比，UA最高四分位数参与者患BPH的可能性降低（ORQ4vs1=0.61，95%CI:0.41-0.91）。亚组分析发现，在60岁以下的参与者中年，非西班牙裔白人、以前吸烟的人、酗酒的人、没有糖尿病的人或患有高血压的人，高UA仍然与BPH呈负相关。结论：UA可能是BPH的潜在保护因子，但其机制有待进一步探讨。

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Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008.

Background: The relationship between uric acid (UA) and benign prostatic hyperplasia (BPH) is controversial and has rarely been studied in American populations.

Methods: Data from two cycles of the National Health and Nutrition Examination Surveys, comprising data from 2005 to 2008, were used. The majority of BPH were identified by self-report. We investigated the relationship between UA and BPH using univariate and multivariate logistic regression analyses.

Results: 2,845 participants were enrolled in the study, including 531 participants with BPH and 2,314 controls. After fully adjusting for all confounders, the risk of developing BPH was reduced by 18% for every 100 μmol/L increase in UA (OR = 0.82, 95% CI: 0.69-0.97, p = 0.023). Participants in the highest quartile of UA were found to have a reduced likelihood of developing BPH (OR_Q4vs1 = 0.61, 95% CI: 0.41-0.91) in comparison to those in the lowest quartile of UA. Subgroup analyses found that among those younger than 60 years, non-Hispanic whites, former smokers, heavy drinkers, those without diabetes, or those with hypertension, high UA remained negatively associated with BPH.

Conclusions: The above results suggest that UA may be a potential protective factor for BPH, but the mechanism needs to be further explored.

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.