Anemia and testosterone deficiency risk: insights from NHANES data analysis and a Mendelian randomization analysis.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-04-29 DOI:10.1080/13685538.2024.2346312

Zhenming Zheng, Jiashan Pan, Ming Liu, Zhimin Chen, Lvwen Zhang, Jingjing Gao, Pan Gao, Xiansheng Zhang

{"title":"Anemia and testosterone deficiency risk: insights from NHANES data analysis and a Mendelian randomization analysis.","authors":"Zhenming Zheng, Jiashan Pan, Ming Liu, Zhimin Chen, Lvwen Zhang, Jingjing Gao, Pan Gao, Xiansheng Zhang","doi":"10.1080/13685538.2024.2346312","DOIUrl":null,"url":null,"abstract":"Background: Previous research has shown that testosterone deficiency (TD) increases the risk of anemia, but it is unclear whether anemia affects testosterone levels. This study investigated the influence of anemia on testosterone levels.Methods: Utilizing data from six NHANES cycles, including demographic, testosterone levels, and hemoglobin concentrations, we employed multivariable-adjusted logistic regression to investigate the relationship between anemia and testosterone levels. Moreover, a two-sample Mendelian randomization (MR) study employing genome-wide association study (GWAS) data examined the causal relationship. Kaplan-Meier survival estimation was used to compared the overall survival (OS) of anemic and nonanemic patients with low testosterone and normal testosterone levels.Results: The inclusion of 21,786 participants (2318 with anemia and19,468 without anemia) revealed that nonanemic patients exhibited higher testosterone levels than did anemic patients (β = 22.616, 95% CI: 3.873-41.359, p = 0.01807). MR analysis confirmed anemia as a cause of TD (OR = 1.045, 95% CI: 1.020-1.071, p < 0.001). Anemic males with low testosterone had reduced OS compared to those with normal levels (p < 0.001).Conclusions: Anemia emerged as a potential risk factor for TD, highlighting a bidirectional relationship between these conditions. Additional prospective investigations are essential for the validation and reinforcement of our findings.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Male","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13685538.2024.2346312","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Previous research has shown that testosterone deficiency (TD) increases the risk of anemia, but it is unclear whether anemia affects testosterone levels. This study investigated the influence of anemia on testosterone levels.

Methods: Utilizing data from six NHANES cycles, including demographic, testosterone levels, and hemoglobin concentrations, we employed multivariable-adjusted logistic regression to investigate the relationship between anemia and testosterone levels. Moreover, a two-sample Mendelian randomization (MR) study employing genome-wide association study (GWAS) data examined the causal relationship. Kaplan-Meier survival estimation was used to compared the overall survival (OS) of anemic and nonanemic patients with low testosterone and normal testosterone levels.

Results: The inclusion of 21,786 participants (2318 with anemia and19,468 without anemia) revealed that nonanemic patients exhibited higher testosterone levels than did anemic patients (β = 22.616, 95% CI: 3.873-41.359, p = 0.01807). MR analysis confirmed anemia as a cause of TD (OR = 1.045, 95% CI: 1.020-1.071, p < 0.001). Anemic males with low testosterone had reduced OS compared to those with normal levels (p < 0.001).

Conclusions: Anemia emerged as a potential risk factor for TD, highlighting a bidirectional relationship between these conditions. Additional prospective investigations are essential for the validation and reinforcement of our findings.

查看原文本刊更多论文

贫血与睾酮缺乏症风险：NHANES 数据分析和孟德尔随机分析的启示。

背景：以往的研究表明，睾酮缺乏症（TD）会增加贫血的风险，但目前还不清楚贫血是否会影响睾酮水平。本研究调查了贫血对睾酮水平的影响：利用六个 NHANES 周期的数据（包括人口统计学、睾酮水平和血红蛋白浓度），我们采用了多变量调整逻辑回归法来研究贫血与睾酮水平之间的关系。此外，一项采用全基因组关联研究（GWAS）数据的双样本孟德尔随机化（MR）研究也检验了两者之间的因果关系。研究采用卡普兰-梅耶生存估计法比较了睾酮水平低的贫血患者和睾酮水平正常的非贫血患者的总生存率（OS）：纳入 21786 名参与者（2318 名贫血患者和 19468 名非贫血患者）后发现，非贫血患者的睾酮水平高于贫血患者（β = 22.616，95% CI：3.873-41.359，p = 0.01807）。磁共振分析证实贫血是导致 TD 的原因之一（OR = 1.045，95% CI：1.020-1.071，p p 结论：贫血是导致 TD 的潜在风险因素，凸显了这些疾病之间的双向关系。要验证和巩固我们的研究结果，必须进行更多的前瞻性调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.