Factors associated with concomitant prostate cancer in benign prostatic hyperplasia patients aged 60 years and above.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2024-12-01 Epub Date: 2024-08-12 DOI:10.1080/13685538.2024.2388529

Mengdi Wu, Kun Zheng, Yanjie Cao, Qiaoxiang Yin, Yue Hu, Qitao Ren, Huijing Zhu, Xiaohua Lan, Weiwei Zhu

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引用次数: 0

Abstract

Objective: Prostate hyperplasia and cancer are more prevalent in middle-aged and elderly men. Previous studies have linked both disorders to androgen receptors. Herein, efforts were made to identify factors associated with prostate cancer in patients ≥60 years, aiming to enhance their health management.

Methods: An analytical framework was established utilizing the "Prostate Cancer Early Warning Dataset" from the National Clinical Medical Science Data Center. Variables selection was conducted through LASSO regression, followed by multifactorial logistic stepwise regression to construct a predictive model.

Results: A total of 1,502 patients with BPH and 294 with combined PCa were hereby included. Multivariate regression delineated several independent predictors of PCa coexistence, including age (OR [95% CI]: 1.06 [1.04-1.09], p < 0.001), fPSA/tPSA ratio (OR [95% CI]: 0.01 [0.002-0.05], p < 0.001), serum inorganic phosphorus (OR [95% CI]: 5.85 [2.61-13.15], p < 0.001), globulin levels (OR [95% CI]: 1.06 [1.02-1.11], p = 0.005), serum potassium (OR [95% CI]: 0.58 [0.40-0.86], p = 0.006), low-density lipoprotein (LDL) cholesterol (OR [95% CI]: 1.28 [1.06-1.54], p = 0.009), among others.

Conclusion: The analysis revealed connections between PCa occurrence in men aged over 60 and BPH, along with specific serum biomarkers such as inorganic phosphorus, globulin, LDL cholesterol, lower fPSA/tPSA ratios and serum potassium.

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60 岁及以上良性前列腺增生症患者合并前列腺癌的相关因素。

目的：前列腺增生和癌症在中老年男性中发病率较高。以往的研究表明，这两种疾病都与雄激素受体有关。在此，我们努力找出与≥60岁患者前列腺癌相关的因素，以加强对他们的健康管理：方法：利用国家临床医学科学数据中心的 "前列腺癌预警数据集 "建立分析框架。方法：利用国家临床医学科学数据中心的 "前列腺癌早期预警数据集 "建立分析框架，通过LASSO回归进行变量选择，然后通过多因素逻辑逐步回归构建预测模型：共纳入 1,502 名良性前列腺增生症患者和 294 名合并 PCa 患者。多变量回归确定了 PCa 并发症的几个独立预测因素，包括年龄（OR [95% CI]：1.06 [1.04-1.09]，p p p = 0.005）、血清钾（OR [95%CI]：0.58 [0.40-0.86]，p = 0.006）、低密度脂蛋白（LDL）胆固醇（OR [95%CI]：1.28 [1.06-1.54]，p = 0.009）等：分析表明，60 岁以上男性 PCa 的发生与良性前列腺增生症以及无机磷、球蛋白、低密度脂蛋白胆固醇、较低的 fPSA/tPSA 比率和血清钾等特定血清生物标志物有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.