Archives of Iranian Medicine最新文献

{"title":"Efficacy and Safety of Tofacitinib in Lichen Planopilaris: A Retrospective Series of 74 Patients.","authors":"Mehdi Goodarzi, Sahar Dadkhahfar, Faranak Yahyaei, Zahra Razzaghi, Hamideh Moravvej","doi":"10.34172/aim.33237","DOIUrl":"10.34172/aim.33237","url":null,"abstract":"<p><strong>Background: </strong>Lichen planopilaris (LPP) is a rare, inflammatory condition leading to scarring alopecia, predominantly affecting middle-aged women. Traditional treatments have shown limited efficacy, highlighting the need for novel therapeutic approaches. Tofacitinib, a Janus kinase (JAK) inhibitor, has shown promise in treating various autoimmune diseases, including autoimmune dermatological disorders. This study aims to evaluate the efficacy of tofacitinib in treating patients with LPP.</p><p><strong>Methods: </strong>We conducted a retrospective, single-center observational study at Shohadaye Tajrish Hospital, reviewing records of 74 patients with biopsy-confirmed LPP who had extensive and treatment-resistant disease. Patients were treated with tofacitinib 5 mg twice daily for at least 16 weeks. Efficacy was assessed using the LPP Activity Index (LPPAI), and adverse events were monitored.</p><p><strong>Results: </strong>This study evaluated 74 patients with LPP, predominantly female (83.3%), with a mean age of 46.64±8.05 years. The mean LPPAI score significantly decreased from 4.61±1.26 before treatment to 1.73±1.68 after six months (<i>P</i><0.0001). Response rates varied: 21.62% within 1‒3 months, 24.32% within 3‒6 months, 33.78% within 6‒12 months, and 8.10% within 12‒24 months, with 6.75% showing no response. Adverse effects included headache (8.10%), hyperlipidemia (2.70%), elevated liver enzymes (5.40%), nausea (6.75%), and high blood pressure (4.15%).</p><p><strong>Conclusion: </strong>Tofacitinib represents a promising treatment for LPP, providing significant improvement in disease activity for most patients. Further research is needed to refine treatment protocols, understand predictors of response, and address gender-specific adverse effects.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"24-28"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Uric Acid Level and Intraventricular Hemorrhage in Patients with Acute Hemorrhagic Stroke: A Retrospective Observational Study.","authors":"Su Jin Choi, Min Wook So, Sunggun Lee, Seung Won Choi, Doo-Ho Lim","doi":"10.34172/aim.31804","DOIUrl":"10.34172/aim.31804","url":null,"abstract":"<p><p>In contrast to experimental studies indicating the neuroprotective role of uric acid (UA), recent clinical studies have shown that increased UA is associated with a risk of acute hemorrhagic stroke. However, the association of UA with intraventricular hemorrhage (IVH) has not been adequately evaluated. In this study, we determined the relationship between UA and IVH in patients with intracerebral hemorrhage (ICH). We included 721 patients with ICH who were admitted to a tertiary hospital in South Korea. The patients were stratified into quartiles based on their UA levels. IVH decreased continuously across all quartiles of UA. After adjusting for confounding factors, the odds ratio (OR) for IVH was significantly lower in the fourth quartile compared with that in the first quartile (OR: 0.713; 95% CI: 0.546-0.934; <i>P</i>=0.045). In conclusion, UA is independently associated with IVH, suggesting its protective role against IVH in patients with ICH.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"40-43"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effects of World War II on Infectious Diseases in the Persian Gulf.","authors":"Mohammad Jafar Chamankar","doi":"10.34172/aim.33705","DOIUrl":"10.34172/aim.33705","url":null,"abstract":"","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"72"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Breast Cancer Sentinel Lymph Node Detection Rate: First Large Scale Multi-Centric Data for Technetium Phytate.","authors":"Ramesh Omranipour, Mehrshad Abbasi, Newsha Nazarian, Bardia Gholami, Samareh Heydari, Bita Eslami, Alireza Abdollahi, Sadaf Alipour","doi":"10.34172/aim.33700","DOIUrl":"10.34172/aim.33700","url":null,"abstract":"","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"71"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr Virus Encephalitis as a Cause of Status Epilepticus - A Rare Encounter.","authors":"Ayisha Farooq Khan, Tooba Arshad, Faryal Abdy, Mohammad Wasay","doi":"10.34172/aim.28844","DOIUrl":"10.34172/aim.28844","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV) is associated with infectious mononucleosis and is known to cause various neurological complications, albeit rarely. EBV encephalitis is a rare manifestation, and even rarer is its presentation as status epilepticus. To date, fewer than ten cases of EBV encephalitis presenting as status epilepticus have been reported globally. We report a case of an 18-year-old girl who presented with fever followed by seizures. She went into status epilepticus the next day. Cerebrospinal fluid (CSF) analysis showed lymphocytic predominance. Brain imaging showed bilateral symmetric hyperintense lesions in the caudate and the putamen. EBV IgG and IgM were found to be positive. The patient was treated with ganciclovir and anti-epileptics and she improved gradually. Our case emphasizes the importance of considering EBV encephalitis as a potential cause of status epilepticus, even in individuals without immunodeficiency. Recognizing atypical presentations and appropriate diagnostic investigations can facilitate early diagnosis and treatment initiation.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"67-70"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviving Iran's Science Diplomacy: New Horizons Opened by President Pezeshkian.","authors":"Farid Rahimi, Mohammad Javad Zarif, Amin Talebi Bezmin Abadi","doi":"10.34172/aim.33115","DOIUrl":"10.34172/aim.33115","url":null,"abstract":"","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"61-62"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Psychiatric Disorders with Pedestrian Safety Behaviors: Baseline Findings from Persian Traffic Cohort.","authors":"Mostafa Farahbakhsh, Fatemeh Niknami, Homayoun Sadeghi-Bazargani, Sanaz Noruzi, Sepideh Harzand-Jadidi","doi":"10.34172/aim.29961","DOIUrl":"10.34172/aim.29961","url":null,"abstract":"<p><strong>Background: </strong>Mental health problems can disrupt traffic behaviors through reduced cognitive function, poor decision-making, increased behavioral errors, and concentration problems. This study aimed to examine the role of psychiatric disorders in pedestrians ' traffic behavior.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 275 pedestrians of the Persian Traffic Cohort (PTC) in 2022. The Pedestrian Traffic Behavior Questionnaire, Kessler's Psychological Distress Scale, and the Structured Assessment of Personality Abbreviated Scale (SAPAS) screening questionnaires for people over 14 years were completed. Then, those who had a score above 3 on the SAPAS or a score above 20 on Kessler's scale took part in a psychiatric interview by a psychiatrist or psychiatric resident. The data were analyzed in SPSS v. 26 via independent samples <i>t</i>-test, analysis of variance, and multiple linear regression.</p><p><strong>Results: </strong>The score of positive behaviors was significantly higher in pedestrians without depressive disorder than in those with depressive disorder (95% CI: 42.49-51.17, <i>P</i> value<0.001). The score of aggressive behaviors was significantly higher in pedestrians with depressive disorder than in those without (95% CI: 24.98-28.87, <i>P</i> value=0.001). There was no statistically significant difference between the two groups of pedestrians with and without generalized anxiety disorder in the scores of traffic behavior dimensions (<i>P</i> value>0.05).</p><p><strong>Conclusion: </strong>There was a significant relationship between pedestrians with depressive disorder and the score of positive and aggressive traffic behaviors. Meanwhile, the pedestrians' anxiety disorder was not significantly related to any of their behavioral dimensions. More comprehensive studies should be conducted, taking into account more mental disorders and larger samples, to more precisely explain the impact of psychiatric disorders on pedestrians' traffic behavior.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pooled Prevalence of Attributed Factors of Suicide in Iran: A Systematic Review and Meta-analysis.","authors":"Parsa Rouzrokh, Fatemeh Abbasi Feijani, Yeganeh Moshiri, Sulmaz Ghahramani, Kamran Bagheri Lankarani","doi":"10.34172/aim.31276","DOIUrl":"10.34172/aim.31276","url":null,"abstract":"<p><strong>Background: </strong>Suicide poses a critical global public health concern, and distinguishing between suicides and suicide attempts underscores the need for targeted interventions. This investigation aimed to determine the pooled prevalence of factors contributing to suicide in Iran, including socio-economic, demographic, and geographical factors.</p><p><strong>Methods: </strong>A systematic search was conducted across Web of Science, Scopus, PubMed, SID, Magiran, Elmnet, ISC, Irandoc, and Noormags databases up to July 2023. We included primary observational studies of acceptable quality that examined the prevalence of factors contributing to suicide in Iranian regions. The findings were screened for eligibility and quality, followed by a review of selected articles, from which data were extracted and analyzed.</p><p><strong>Results: </strong>Out of 1646 initial articles, 68 were selected for review and 54 for meta-analysis. The pooled prevalence rates of contributing factors were calculated as follows: male gender (64.3, 95% CI: 62.6‒66.0%), age over 25 (57.9%, 95% CI: 51.0‒64.5%), under diploma education (73.4%, 95% CI: 62.1‒82.3%), employment issues (66.4%, 95% CI: 59.7‒72.5%), urban living (61.7%, 95% CI: 53.8‒69.1%), past medical history (8.5%, 95% CI: 4.9‒14.2%), past psychiatric history (20.7%, 95% CI: 15.5‒27.1%), past suicidal attempt (12.2%, 95% CI: 8.5‒17.0%), substance abuse history (28.4%, 95% CI: 20.1‒38.3%), spring season (29.8%, 95% CI: 26.7‒33%), and hanging method (46.1%, 95% CI: 41.6‒50.6%). Significant regional differences were observed in the prevalence of gender, age, and suicide methods between western and non-western areas.</p><p><strong>Conclusion: </strong>This study describes key factors of suicides in Iran. Despite higher rates among those over 25, many young individuals are affected. Urban living and low educational attainment are significant factors. Moreover, notable regional differences were observed in gender, age, and suicide methods between western and non-western areas. These findings highlight the need for additional research related to record-keeping challenges and can guide Iranian health policymakers in developing strategies for screening and treating vulnerable individuals.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 1","pages":"44-60"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile and Outcomes of Pulmonary Embolism in Central Iran: A Retrospective Cohort Study.","authors":"Abbas Andishmand, Leila Sharifi, Seyedeh Mahdieh Namayandeh","doi":"10.34172/aim.31907","DOIUrl":"10.34172/aim.31907","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary embolism (PE) is a significant public health concern. This retrospective cohort study examines the clinical profiles and outcomes of patients diagnosed with PE at a medical center in central Iran, aiming to identify mortality predictors during hospitalization and follow-up.</p><p><strong>Methods: </strong>Data from 109 patients diagnosed with PE were analyzed, with a median follow-up of 23 months. The collected information included demographic and clinical characteristics, laboratory findings, treatment protocols, and outcomes. Logistic regression and Kaplan-Meier survival analysis were used to identify independent mortality predictors and assess survival impact.</p><p><strong>Results: </strong>The mean age was 59.2 years (±19.7), with 51.4% male. Common symptoms included dyspnea (86%) and chest pain (53%), with non-massive PE being the most prevalent (63%). Independent mortality predictors identified were age (odds ratio [OR] 1.065 per year, <i>P</i><0.001), female sex (OR 4.421, <i>P</i>=0.009), and PE severity (OR 0.262, <i>P</i>=0.023). Kaplan-Meier analysis showed reduced survival probabilities in females (<i>P</i>=0.009), those with provoked PE (<i>P</i>=0.002), patients over 65 (<i>P</i>=0.016), and individuals with comorbidities (<i>P</i>=0.018). In-hospital mortality was 10.1%, linked to provoked massive PE, absence of thrombolytic therapy, and reduced left ventricular ejection fraction (LVEF).</p><p><strong>Conclusion: </strong>In this cohort, age, sex, and PE severity were significant mortality predictors, while provoked PE, advanced age, and comorbidities were associated with lower mid-term survival probabilities.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 12","pages":"667-673"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Anatomical Variation: Intrathoracic Liver Caudate Lobe: A Case Report.","authors":"Beyza Yaşar Akpınar, Hüseyin Umut Baştürk, Şeyma Başlılar, Yahya Baraç, Bengü Şaylan","doi":"10.34172/aim.31604","DOIUrl":"10.34172/aim.31604","url":null,"abstract":"<p><p>We present a case with an intrathoracic caudate lobe in a 45-year-old woman who referred with a complaint of nonspecific chest pain. She denied previous history of trauma or surgery. Computed tomography (CT) pulmonary angiography showed a paravertebral, soft tissue mass which raised suspicion of a pleural tumor. In the coronal plane, the mass was protruding to the abdomen and had similar density with liver. Magnetic resonance imaging confirmed the diagnosis.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 12","pages":"707-709"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}