急性出血性卒中患者血清尿酸水平与脑室内出血:一项回顾性观察研究。

IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Su Jin Choi, Min Wook So, Sunggun Lee, Seung Won Choi, Doo-Ho Lim
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引用次数: 0

摘要

与表明尿酸(UA)具有神经保护作用的实验研究相反,最近的临床研究表明尿酸升高与急性出血性中风的风险相关。然而,UA与脑室内出血(IVH)的关系尚未得到充分评估。在这项研究中,我们确定了脑出血(ICH)患者UA与IVH的关系。我们纳入了韩国一家三级医院收治的721例脑出血患者。根据UA水平将患者分为四分位数。IVH在UA的所有四分位数中持续下降。调整混杂因素后,第四四分位数IVH的比值比(OR)显著低于第一四分位数(OR: 0.713;95% ci: 0.546-0.934;P = 0.045)。综上所述,UA与IVH独立相关,提示其对脑出血患者IVH具有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum Uric Acid Level and Intraventricular Hemorrhage in Patients with Acute Hemorrhagic Stroke: A Retrospective Observational Study.

In contrast to experimental studies indicating the neuroprotective role of uric acid (UA), recent clinical studies have shown that increased UA is associated with a risk of acute hemorrhagic stroke. However, the association of UA with intraventricular hemorrhage (IVH) has not been adequately evaluated. In this study, we determined the relationship between UA and IVH in patients with intracerebral hemorrhage (ICH). We included 721 patients with ICH who were admitted to a tertiary hospital in South Korea. The patients were stratified into quartiles based on their UA levels. IVH decreased continuously across all quartiles of UA. After adjusting for confounding factors, the odds ratio (OR) for IVH was significantly lower in the fourth quartile compared with that in the first quartile (OR: 0.713; 95% CI: 0.546-0.934; P=0.045). In conclusion, UA is independently associated with IVH, suggesting its protective role against IVH in patients with ICH.

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来源期刊
Archives of Iranian Medicine
Archives of Iranian Medicine 医学-医学:内科
CiteScore
4.20
自引率
0.00%
发文量
67
审稿时长
3-8 weeks
期刊介绍: Aim and Scope: The Archives of Iranian Medicine (AIM) is a monthly peer-reviewed multidisciplinary medical publication. The journal welcomes contributions particularly relevant to the Middle-East region and publishes biomedical experiences and clinical investigations on prevalent diseases in the region as well as analyses of factors that may modulate the incidence, course, and management of diseases and pertinent medical problems. Manuscripts with didactic orientation and subjects exclusively of local interest will not be considered for publication.The 2016 Impact Factor of "Archives of Iranian Medicine" is 1.20.
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