Archives of Iranian Medicine最新文献

{"title":"Association Between Adequacy and Moderation of Quality of Diet with Metabolic Syndrome Parameters Among Iranian Health Workers Based on the Baseline Data of Employees Health Cohort Study.","authors":"Mohammad Hossein Sharifi, Elahe Mansouriyekta, Seyed Jalil Masoumi, Alireza Mirahmadizadeh, Zahra Rostami Ghotbabadi","doi":"10.34172/aim.33193","DOIUrl":"10.34172/aim.33193","url":null,"abstract":"<p><strong>Background: </strong>A healthy diet is essential for managing metabolic syndrome (MetS), but moderation and dietary adequacy remain ambiguous.</p><p><strong>Methods: </strong>Data from the recruiting phase of the Shiraz University of Medical Sciences Employees Health Cohort Study (SUMS EHCS) were utilized to conduct this cross-sectional analysis. A validated 168-item semi-quantitative food frequency questionnaire (FFQ) was used to collect dietary data in the Persian cohort. In the current study, the healthy eating index (HEI-2015) includes two components, namely adequacy and moderation which were used to evaluate the quality of the diet.</p><p><strong>Results: </strong>The study included 3380 health workers, with a mean age of 41.81±7 years and 55.2% female. Among them, 22.3% met the ATP III criteria for MetS. The mean total HEI, adequacy, and moderation scores were 63.89±9.53, 41.03±5.88, and 20.13±4.90, respectively. Adjusted model analysis showed no significant correlation between diet adequacy and MetS or its components, but found a significant association between diet moderation and MetS (OR: 1.03 [1.008-1.05]), abdominal obesity (OR: 1.02 [1.003-1.04]), elevated serum triglycerides (TGs) (OR: 1.02 [1-1.03]), and elevated fasting blood sugar (FBS) (OR: 1.03 [1.005-1.05]).</p><p><strong>Conclusion: </strong>This study found that there was a significant correlation between diet moderation and abdominal obesity, elevated serum TGs, elevated FBS, and MetS. Future studies on the topic are recommended.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"182-188"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Iranian Family with a Novel Missense Variant in <i>MYO9B</i> Gene Causing Charcot-Marie-Tooth Disease.","authors":"Maryam Beheshtian, Maryam Mozaffarpour Nouri, Fatemeh Ahangari, Mina Makvand, Banafsheh Salmani, Ariana Kariminejad, Hossein Najmabadi, Shahriar Nafissi","doi":"10.34172/aim.33244","DOIUrl":"10.34172/aim.33244","url":null,"abstract":"<p><p>A heterogeneous clinical and genetic Charcot-Marie-Tooth (CMT) disease, with peripheral nerve damage resulting in chronic motor and sensory polyneuropathy, has been linked to the mutation in over a hundred genes. We report the adult onset of CMT in three siblings of an Iranian family manifesting with muscle weakness and wasting, foot drop, and pes cavus. Whole-exome sequencing (WES) identified a novel homozygous missense mutation in the <i>MYO9B</i> gene, inherited from obligatory carrier parents. This likely pathogenic variant contributes to chronic demyelinating sensorimotor polyneuropathy and conduction blocking in the ulnar and median nerves in these patients. To our knowledge, our study is the first report on MYO9B-related CMT in Iranian patients. Previously, a few variations in the <i>MYO9B</i> gene were reported to cause CMT. Here we emphasize the potential disruptive role of the detected variant of <i>MYO9B</i> in CMT pathogenesis and also highlight the importance of WES for the proper diagnosis of CMT disease. We also compared the clinical presentations of Iranian and Italian patients expanding the clinical and mutational spectrum of MYO9B-related neuropathies.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"236-239"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Services Delivery by Non-physicians and Associated Factors in Iran: A Cross-sectional Study in 2023.","authors":"Ahmad Mehri, Seyed Saeed Hashemi Nazari, Farideh Mostafavi, Mehran Rostami Varnousfaderani, Seyed Amirhosein Mahdavi, Reza Haj-Manouchehri, Seyed Davood Mirotorabi, Mohsen Saberi Isfeedvajani","doi":"10.34172/aim.31947","DOIUrl":"10.34172/aim.31947","url":null,"abstract":"<p><strong>Background: </strong>The increasing demand for healthcare services and some associated factors including lack of physicians, lack of trust in physicians, ineffectiveness of treatments and high costs may be have led to a rise in non-physician-provided services. This study aims to assess health services delivery by non-physicians and its associated factors in Iran.</p><p><strong>Methods: </strong>This study was a cross-sectional study conducted using a convenience sampling method in the Iranian community in 2023. A standard questionnaire with 45 questions was developed based on focus group discussions and a validation process to assess the status of receiving services in six medical areas including traditional medicine, abortion, traditional dentistry, obesity and slimming diets, bone setting, and addiction treatment. Data collection was carried out using online questionnaires on Iranian and non-Iranian social media platforms. Descriptive and analytical statistics were used to analyze the data, with logistic regression adjusting for various demographic factors.</p><p><strong>Results: </strong>Out of 1713 participants, 53.9% (95% CI: 51.5%-56.3%) were women, and the majority were in the 30-40 age group. Traditional Islamic medicine was the most commonly sought service, with 56% (95% CI: 51.2%-60.8%) of users receiving it from non-physicians. Satisfaction with non-physician services varied, with 32.1% (95% CI: 25.8%-38.4%) reporting high satisfaction for traditional medicine, but only 49.4% (95% CI: 40.5%-58.3%) for experimental dentistry. Key reasons for choosing non-physician providers included the effectiveness of traditional treatments and fear of modern medicine's side effects.</p><p><strong>Conclusion: </strong>The result showed that the use of non-physician services can be considerable and that necessary interventions should be designed to standardize treatments and deal with substandard providers who may be harmful to the health of the community.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"207-216"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Artificial Intelligence for Bone Age Assessment in Iranian Children and Adolescents: An Exploratory Study.","authors":"Mehrzad Lotfi, Nahid Abolpour, Mohammadreza Ghasemi, Hajar Heydari, Reza Pourghayumi","doi":"10.34172/aim.32070","DOIUrl":"10.34172/aim.32070","url":null,"abstract":"<p><strong>Background: </strong>To investigate whether the bone age (BA) of Iranian children could be accurately assessed via an artificial intelligence (AI) system. Accurate assessment of skeletal maturity is crucial for diagnosing and treating various musculoskeletal disorders, and is traditionally achieved through manual comparison with the Greulich-Pyle atlas. This process, however, is subjective and time-consuming. Recent advances in deep learning offer more efficient and consistent BA evaluations.</p><p><strong>Methods: </strong>From left-hand radiographs of children aged 1-18 years who presented to a tertiary research hospital, 555 radiographs (220 boys and 335 girls) were collected. The reference BA was determined via the Greulich and Pyle (GP) method by two radiologists in consensus. The BA was then estimated to use a deep learning model specifically developed for this population. Model performance was evaluated using multiple metrics: Mean square error (MSE), mean absolute error (MAE), intra-class correlation coefficient (ICC), and 95% limits of agreement (LoA). Gender-specific results were analyzed separately.</p><p><strong>Results: </strong>The model demonstrated acceptable accuracy. For boys, MSE was 0.55 years, MAE was 0.59 years, ICC was 0.74, and the 95% LoA ranged from -0.8 to 1.2 years. For girls, MSE was 0.59 years, MAE was 0.61 years, ICC was 0.82, and the 95% LoA ranged from -0.6 to 1.0 years. These results indicate stronger predictive accuracy for girls compared to boys.</p><p><strong>Conclusion: </strong>Our findings demonstrate that the proposed deep learning model achieves reasonable accuracy in BA assessment, with stronger performance in girls compared to boys. However, the relatively wide 95% LoA, particularly for boys, and prediction errors at the extremes of the age range highlight the need for further refinement and validation. While the model shows potential as a supplementary tool for clinicians, future studies should focus on improving prediction accuracy, reducing variability, and validating the model on larger, more diverse datasets before considering widespread clinical implementation. Additionally, addressing edge cases and specific conditions that a human reviewer may detect but the model might overlook, will be essential for enhancing its clinical reliability.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"198-206"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction and Characterization of Phenolic Acid Compounds of Zahidi and Khastawi Dates Seed Extract and Evaluation of their Antibacterial Activity.","authors":"Noor Ridha Kadhim, Mohammad Rabbani Khorasgani, Hussam Sami Awayid, Hamid Noorbakhsh","doi":"10.34172/aim.33929","DOIUrl":"10.34172/aim.33929","url":null,"abstract":"<p><strong>Background: </strong>The date fruit is a remarkable source of nutraceuticals and bioactive compounds. Different types of phenolic compounds with high antioxidant capacity are found in date seed extract. Additionally, these compounds can be potential antibacterial agents to combat antibiotic resistance strains. Therefore, the main idea of the current study was to quantify five key phenolic acids in the ethanolic extract of Zahidi and Khastawi dates seed and to examine their antibacterial activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).</p><p><strong>Methods: </strong>The concentration of gallic acid, ferulic acid, p-coumaric acid, sinapic acid and cinnamic acid in the seed extracts were determined by high performance liquid chromatography (HPLC). Then, antibacterial activity of date seed extracts was analyzed using well diffusion method. Furthermore, a scanning electron microscopy (SEM) analysis was performed to confirm the antibacterial effects of the seed extracts.</p><p><strong>Results: </strong>Phenolic acids were found to be in the range of 10.59 to 33.65 µg mg^-1 in Zahidi and 13.69 to 41.56 µg mg^-1 in Khastawi date seed extract. Gallic acid was the dominant phenolic acid, while cinnamic acid was seen in the lowest concentrations compared with the other phenolic acids in both cultivars. Antibacterial activity study showed that the growth inhibition effect of Khastawi date (14±0.21 mm) was higher than that of Zahidi date (8±0.13 mm) against MRSA. As well, the maximum DPPH scavenging percentage was 79% and 62% for the Khastawi and Zahidi date seed extracts, respectively. Also, SEM analysis suggested that treatment of MRSA with date seed extract resulted in a significant disruption of bacterial structure.</p><p><strong>Conclusion: </strong>It can be concluded that date seed extract can be considered as a potential source of antibacterial compounds for the drug discovery purposes.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"217-224"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Russian Flu in Iran from 1889 to 1894.","authors":"Seyyed Alireza Golshani, Ghobad Mansourbakht, Ghazaleh Mosleh","doi":"10.34172/aim.33524","DOIUrl":"10.34172/aim.33524","url":null,"abstract":"<p><p>The 'Russian flu,' also referred to as the 'Asiatic flu,' spread globally between 1889 and 1894. According to estimates from international organizations, this epidemic resulted in the deaths of approximately one million individuals. However, there is no information available on the exact number of deaths in Iran. The earliest outbreak of the epidemic was reported in May 1889 in Bukhara, Central Asia, which was part of the Russian Empire. The Russian Railway facilitated the spread of the epidemic from Siberia to the easternmost regions of Russia, westward to Moscow, and subsequently to countries such as China, Sweden, Finland, and Western Europe, eventually reaching the United States and Argentina. It subsequently spread from southern Russia to the South Caucasus and Baku, then moved into Iran from the north, northeast, and northwest, suddenly appearing in cities such as Bandar Anzali, Sari, Rasht, Mashhad, Tabriz, Tehran, Isfahan, Shiraz, and Kerman. The epidemic caused unexpected casualties in the country and startled both modern and traditional physicians. Notably, this epidemic, which appeared in Iran in two waves during 1890 and 1892, was somewhat mitigated due to the country's insufficient transportation infrastructure. As Tehran and Tabriz were either overpopulated or closer to Russia, doctors in these cities witnessed more cases of the Russian flu, prompting them to write several medical dissertations on this epidemic. This study examines the Russian flu in Iran as documented in historical, journalistic, and medical records.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"244-251"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Trend of Mortality, Life Expectancy and Excessive Death with Emphasis on the Role of the COVID-19 Pandemic Period in the Isfahan Province: A Cross-sectional Study of Join Point Regression Analysis 2011-2021.","authors":"Maziyar Mollaei Pardeh, Mohammad Hossein Yarmohammadian, Habibollah Azarbakhsh, Golrokh Atighechian, Afshin Ebrahimi, Andishe Hamedi, Mohamad Reza Maracy","doi":"10.34172/aim.31306","DOIUrl":"10.34172/aim.31306","url":null,"abstract":"<p><strong>Background: </strong>Comparing the trends of mortality rates provides valuable insight for policy discussions and promotes awareness of health issues. This study aimed to investigate the changes in mortality rate and life expectancy from 2011 to 2021 and the effect of COVID-19 period on these indices.</p><p><strong>Methods: </strong>We investigated the data of all-cause deaths between 2011 and 2021 by age group, sex and year using Excel spreadsheets from the National Organization for Civil Registration (NOCR), via collected the census method. Joinpoint regression was used to calculate the trend of mortality rate during the study period.</p><p><strong>Results: </strong>During the study period, there were 262,708 deaths, of which 148,919 were men (56.68%). The trend of mortality rate in both sexes has been increasing. Life expectancy in men and women decreased from 76.71 and 80.82 in 2011 to 74.43 and 77.53 in 2021, respectively. From 2018 to 2021, there was a significant increase in standardized mortality rate in men (APC=14.74; 95% CI=5.73; 28.65) and women (APC=14.29; 95% CI=4.67; 28.97). However, from 2011 to 2018, we observed a yearly 2.65% decreasing trend in men which was statistically significant (APC=-2.95, 95% CI=-7.67, -0.84). In women, no significant trend was seen.</p><p><strong>Conclusion: </strong>With the emergence of the COVID-19 epidemic in 2019, the trend of mortality rate and life expectancy changed completely, with additional deaths and decreasing life expectancy. Therefore, prevention, control and treatment of epidemic diseases should be a serious concern of policy makers.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"189-197"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Iran with a Decrease in the Total Fertility Rate.","authors":"Habibollah Azarbakhsh, Seyed Parsa Dehghani","doi":"10.34172/aim.33643","DOIUrl":"10.34172/aim.33643","url":null,"abstract":"","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"255-256"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Low-Dose Aspirin on Pregnancy Outcomes: A Systematic Review and Meta-analysis.","authors":"Wei Wang, Guowei Chang","doi":"10.34172/aim.33275","DOIUrl":"10.34172/aim.33275","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia is a severe pregnancy disorder linked to high maternal and neonatal mortality. This meta-analysis evaluates the effectiveness of low-dose aspirin in reducing the occurrence of preeclampsia and associated outcomes.</p><p><strong>Methods: </strong>A total of 28 trials were included, analyzed using a random-effects model to calculate risk ratios (RR) and 95% confidence intervals (CI). The studies compared low-dose aspirin administered at or before 16 weeks of gestation to a control group. The measured parameters are the effect of low-dose aspirin on pregnancy outcomes. Study inclusion criteria consisted of studies in which low-dose aspirin was administrated at or before 16 weeks of gestation and compared to a control group.</p><p><strong>Results: </strong>Low-dose aspirin significantly reduced preterm (RR=0.52, 95% CI [0.31, 0.88]) and term preeclampsia (RR=0.97, 95% CI [0.69, 1.38]). It also decreased intrauterine growth restriction (RR=0.63, 95% CI [0.54, 0.74]). However, no significant differences were observed for postpartum hemorrhage (RR=0.71, 95% CI [0.49, 1.02]) or gestational hypertension (RR=0.65, 95% CI [0.39, 1.07]). Aspirin doses≥100 mg were more effective in reducing preterm preeclampsia risk compared to doses<100 mg, which showed variable efficacy and greater heterogeneity.</p><p><strong>Conclusion: </strong>Low-dose aspirin significantly decreases the risk of preterm and term preeclampsia but has limited impact on gestational hypertension and postpartum bleeding. Study limitations include the absence of large randomized controlled trials (RCTs) early in pregnancy (before 16 weeks) and small sample sizes in the included trials, complicating precise dose determination.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"225-235"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Cerebral Artery Occlusion Following Levantine Viper (<i>Macrovipera lebetina</i>) Bite: Gács Sign in Snakebite.","authors":"Seyed Mostafa Mirakbari, Reza Gorji","doi":"10.34172/aim.31131","DOIUrl":"10.34172/aim.31131","url":null,"abstract":"<p><p>Acute cerebral thrombotic stroke following a viper snakebite is a rare occurrence. There have been a few documented cases of cerebral infarctions resulting from envenomation by various viper species. However, none of these reports have specifically detailed instances of stroke induced by <i>Macrovipera lebetina</i> envenomation or vessel occlusion without concurrent cerebral infarction. In this study, we present a case of middle cerebral artery (MCA) occlusion in a 56-year-old man who was bitten by a <i>Macrovipera</i> or <i>Vipera lebetina</i> snake. The individual experienced a snakebite on his right foot, leading to subsequent seizure activity and loss of consciousness. Non-contrast computed tomography scan of the brain revealed hyperattenuation of the right MCA, indicating clot occlusion within the artery, commonly referred to as hyperdense MCA sign or Gács sign.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"28 4","pages":"240-243"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}