Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Text Messaging in Encouraging Smoking Cessation among Non-Communicable Disease Patients: What to be Considered?","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.31557/APJCP.2025.26.5.1475","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1475","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1475-1476"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyherbal Formulation as a Therapeutic Strategy for Lung Cancer: Phytochemical Profiling, Molecular Docking, and Pharmacological Evaluation.","authors":"Raman Lakshmi Sundaram, Thirunavukarasou Anand, Konda Mani Saravanan, Kaliyaperumal Prabhu, Abdul Mohamed Yasar, Srinivasan Vivek, Ashok Chetan, Jeyabalan Srikanth","doi":"10.31557/APJCP.2025.26.5.1841","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1841","url":null,"abstract":"<p><p>Globally, lung cancer continues to be the primary cause of both cancer incidence and death. The disease is multifaceted, influenced by numerous external factors and the individual's genetic or epigenetic predisposition to its onset and timing. Upon diagnosis, fewer than one-third of patients present with localized disease amenable to curative multimodal therapy; the remainder have metastatic disease. Currently, numerous treatments are ineffective due to resistance to standard medications or the emergence of distant metastases. Plant-derived natural compounds have garnered significant attention in recent years due to their high permeability and low toxicity. Piper longum, Piper nigrum, Zingiber officinalis, Emblica officinale, Terminalia bellirica, Terminalia chebula, Drynaria quercifolia, Phyllanthus amarus, and Eclipta prostrata are traditional Indian herbs with diverse pharmacological properties. This study assessed the efficacy of active chemicals from the polyherbal formulation on lung cancer target proteins by molecular docking. Preliminary and qualitative phytochemical Antioxidant testing indicated significant pharmacological effects. Moreover, the formulation exhibited modest anti-inflammatory and significant apoptotic action. These findings validate the therapeutic effectiveness of this polyherbal mixture for cancer treatment. Nonetheless, it is imperative to perform further preclinical research to elucidate the mechanisms of action of the molecule, as well as its pharmacodynamic and pharmacokinetic features.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1841-1852"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Structured Exercise-based rehabilitation on Sarcopenia and Quality of life among Head and Neck Cancer Patients Undergoing Chemo-radiotherapy: A Randomized Controlled Trial.","authors":"Cherishma D'Silva, Vijith Shetty, Donald Fernandes, Baeyen Jean-Pierre, Suchetha Kumari N, Saumya Srivastava, Stephen Rajan Samuel","doi":"10.31557/APJCP.2025.26.5.1653","DOIUrl":"10.31557/APJCP.2025.26.5.1653","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is considered an independent prognostic factor for overall survival and performance status in head and neck cancer (HNC) receiving chemo-radiotherapy (CRT). CRT is known to cause sleep disturbances, increased pain perception, depression leading to reduced quality of life (QOL). Exercise-based rehabilitation has emerged as a promising strategy for improving outcomes in HNC. Our study aimed to evaluate effect of exercise on sarcopenia and QOL in patients with HNC receiving CRT.</p><p><strong>Methodology: </strong>Seventy HNC patients, aged 40-70 years TNM stage III- IVb receiving CRT, were randomized into two groups and received intervention for seven weeks. Intervention Group, IG (n=40) received combined aerobic and resistance training according to the ACSM guidelines. Control Group, CG (n=40) were advised to walk according to the NCCN guidelines. Sarcopenia was assessed using Bio Impedance Analyser (BIA), muscle strength using JAMAR hand dynamometer and QOL by FACT H&N on pre CRT day 1 and post 7 weeks. Wilcoxon signed-rank test and Mann-Whitney U test were used to assess within-group differences and  between-group comparisons respectively.</p><p><strong>Results: </strong>80 participants with a mean age of 58.44 ±3.75 years were included. IG showed a smaller decrease in total skeletal muscle mass compared to CG with IGs total skeletal muscle mass decreasing from 35 to 30 and CGs muscle mass decreasing from 40 to 21 (p<0.001). QOL showed significant improvement in CG from 66 to 61 (p < 0.001). In contrast, IGs quality of life saw a minor, non-significant change from 62 to 61.</p><p><strong>Conclusion: </strong>Sarcopenia was lesser in IG compared to CG, highlighting the favourable impact of resistance training and its inclusion in the HNC rehabilitation. However, CG demonstrated significant improvements in quality of life as compared to IG suggesting that quality of life is a multifaceted construct that may not be directly correlated with physical improvements alone.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1653-1660"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysing Differential Alternative Splicing Events and Their Impact on Retinoblastoma Progression Using RNA-seq Metadata.","authors":"Mohamed Hameed Aslam Assane Rachidou, Ayyasamy Vanniarajan, Usha Kim, Bharanidharan Devarajan","doi":"10.31557/APJCP.2025.26.5.1781","DOIUrl":"10.31557/APJCP.2025.26.5.1781","url":null,"abstract":"<p><strong>Objective: </strong>Identify differential alternative splicing (DAS) events and their role in retinoblastoma (RB) progression.</p><p><strong>Methods: </strong>We conducted a meta-analysis of RNA sequencing data from 50 RB tumours and 17 normal retinal tissues to identify DAS events and differential expressed genes (DEGs) in RB progression. We performed functional and pathway enrichment analyses, Weighted Gene Co-expression Network Analysis (WGCNA), and protein-protein interaction analysis.</p><p><strong>Results: </strong>We identified 6136 DAS events involving 1262 genes and 1787 DEGs. Exon skipping and mutually exclusive exons were the most prevalent DAS events. Functional analyses of DAS events containing genes highlighted involvement in E2F targets, cell cycle, G2M checkpoint, MYC targets and fatty acid metabolism pathways. Notably, numerous DAS events were detected in ENO2. WGCNA identified TFDP1, PCNA, and CCNB1,  potentially contributing to RB progression through alternative splicing. Splicing factors ILF2 and HNRNPA1 were highly co-expressed with DAS events containing genes, suggesting their regulatory role in splicing changes during RB progression.</p><p><strong>Conclusions: </strong>Our study reveals significant differential alternative splicing events that play a crucial role in the progression of retinoblastoma. Numerous DAS events, DEGs, and functional analyses underscore the complexity of gene regulation in RB. Importantly, DAS events in TFDP1, PCNA, and CCNB1 may play a crucial role, indicating that alternative splicing is a potential avenue for therapeutic intervention in RB.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1781-1792"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Surgeon Experience on the Recurrence of Non-Muscle Invasive Bladder Cancer (NMIBC), Following Transurethral Resection of the Bladder Tumor (TURBT): A double Blinded Prospective Randomized Study.","authors":"Ayman Kassem, Ahmed Assem, Ahmed Sharawy, Mohamed Ezz El Deen, Ashraf Emran","doi":"10.31557/APJCP.2025.26.5.1767","DOIUrl":"10.31557/APJCP.2025.26.5.1767","url":null,"abstract":"<p><strong>Background: </strong>Transurethral resection of the bladder tumor (TURBT) followed by intravesical instillation therapy is the standard treatment for non-muscle invasive bladder cancer (NMIBC). One of the factors that may affect the risk of recurrence after TURBT is the quality of surgery that may vary between individual surgeons. While there has been a large number of studies demonstrating the ability to reduce the risk of recurrence of NMIBC with different types of the intravesical therapy, less attention was paid to the quality of TURBT in improving long-term treatment results. The aim of the study is to evaluate the effect of the quality of TURBT on the recurrence rate of NMIBC based on surgeon experience.</p><p><strong>Methods: </strong>The study is a double blinded prospective randomized study conducted on 50 patients with NMIBC. who underwent 126 procedures (50 primary cystoscopies ,26 restaging cystoscopies and 50 check cystoscopies at three months). All Treatment-naive patients with NMIBC candidate for TURBT were included, with exclusion of patients with previous history of TURBT, previous open bladder surgery, patients with urethral stricture, patients with muscle invasive bladder cancer. And patients who lost follow up. Patients were randomized by closed envelope into two groups; Group A included 25 patients who underwent TURBT by a senior surgeon (more than 5 years' experience), and Group B included 25 patients underwent TURBT by a qualified junior surgeon (less than 5 years' experience).  Restaging cystoscopy at 2-6 weeks (if indicated) and follow up cystoscopy at three months were performed by another senior surgeon (who was blinded to the name of the first surgeon).</p><p><strong>Results: </strong>No statistically significant difference was found between both groups regarding the incidence of complications (urethral injury, bladder perforation, ureteric injury, obturator reflex), Group B showed a statistically significant longer operative time, postoperative irrigation time, more hemoglobin loss, longer hospital stay, and higher 3 months' recurrence rates. Moreover, senior surgeons' specimens were more likely to include detrusor muscles.</p><p><strong>Conclusion: </strong>surgeon's experience has significant impact on the quality of TURBT and risk of recurrence of NMIBC. With less operative time, less hemoglobin drop, and less hospital stay.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1767-1771"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling of Patient Needs for Fulfillment of Spiritual Health and Social Support with Anxiety Levels and Quality of Life of Cancer Patients.","authors":"Siti Nur Qomariah, Chindy Maria Orizani, Iswati Iswati, Warsini Warsini, Tunjung Sri Yulianti, Budi Kristanto","doi":"10.31557/APJCP.2025.26.5.1727","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1727","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to explain the model of fulfilling basic spiritual health needs and social support with the goal of improving quality of life and alleviating the anxiety of cancer patients.</p><p><strong>Methods: </strong>This research is a cross-sectional study. The study population was comprised of patients with cancer at the Indonesian Cancer Foundation, Cancer Patient Shelter, and Dr. Moewardi Surakarta Hospital. The sample size was 200 respondents who were selected using the purposive sampling technique. The independent variables were spiritual health and social support. The dependent variables were the anxiety level and quality of life of patients with cancer. The instrument used was a questionnaire, and data analysis was performed using Structured Equation Modeling - Partial Least Squares test.</p><p><strong>Results: </strong>This study analyzed the sociodemographic traits of 200 patients with cancer, focusing on age, type of cancer, and family support. The majority of participants were female, and their companion families included children and their spouses. Most patients had breast cancer, intestinal cancer, and rare pancreatic cancers. The study found that most patients had high spiritual health (126 respondents). The majority of their family members provided good social support (188 respondents). The anxiety level of the patients was mild (92 respondents). The quality of life of the cancer patients was found to be good (150 respondents). The study found that spiritual health and social support were influential, positive, and significant, with significant t-statistic values for anxiety level and quality of life.</p><p><strong>Conclusion: </strong>Social support and spiritual health are essential elements of comprehensive cancer care. Both elements are crucial for enhancing coping mechanisms, quality of life, and treatment outcomes. Recognizing and supporting the spiritual well-being and social support of patients is crucial for all involved in their treatment.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1727-1734"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Selective VDR Gene Polymorphisms with Diffuse Large B-Cell Lymphoma (DLBCL) in a South Indian Population.","authors":"Annuja Anandaradje, Shravan Venkatraman, Luxitaa Goenka, Prasanth Ganesn, Shyam Kumar Tripathi, Jayanthi Mathaiyan, Sandhiya Selvarajan","doi":"10.31557/APJCP.2025.26.5.1761","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1761","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of Diffuse Large B-Cell Lymphoma (DLBCL) in India ranges from 34% to 60%. The prognosis for DLBCL can vary widely depending on various factors, including vitamin D deficiency. Research suggests that low vitamin D levels may be linked to poor overall survival (OS) and progression-free survival (PFS) in DLBCL patients. Additionally, polymorphisms in the vitamin D receptor (VDR) gene, specifically the BsmI and TaqI alleles, have been significantly associated with disease prognosis. However, the association of VDR polymorphisms and vitamin D deficiency with DLBCL is yet to be explored. Therefore, this study aims to evaluate the association of VDR gene polymorphisms (BsmI, TaqI, FokI, ApaI) in DLBCL patients.</p><p><strong>Methods: </strong>In this cross-sectional study, 50 treatment-naive DLBCL patients from southern part of India were included. 100 samples of unrelated apparently healthy controls were used as comparator. Demographic characteristics of DLBCL patients were recorded and SNPs in VDR (real time polymerase chain reaction) were assessed. All analyses were performed using SPSS (V26). P<0.05 was considered statistically significant.</p><p><strong>Results: </strong>The frequencies of mutant genotypes [TT- BsmI, AG- TaqI and AG- FokI] were significantly associated with a reduced risk of DLBCL, decreasing the risk DLBCL by 71% (OR=0.29, 95% CI= 0.105 to 0.807), 72% (OR=0.28, 95% CI= 0.133 to 0.608) and 70% (OR=0.3, 95% CI= 0.07 to 1.225). Additionally, comparison with other Indian studies and ethnic groups revealed significant distinctions in VDR genotypes. Further, the haplotype analysis of SNPs in the VDR gene revealed significant association of C-A-G-T haplotype (rs731236-rs7975232-rs1544410-rs2228570) with the disease phenotype.</p><p><strong>Conclusion: </strong>The study shows significant association of BsmI, TaqI, and FokI VDR SNPs with DLBCL.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1761-1766"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Chemo-Preventive Potential of Calligonum polygonoides Stem Extract Against DMBA Induced Skin Carcinogenesis.","authors":"Gyan Prakash Meghwal, Mahendra Kumar Jeengar, Shivani Jangeer, Kamlesh Kumar Sharma, Dev Dutt Patel, Priyadarshi Meena","doi":"10.31557/APJCP.2025.26.5.1831","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1831","url":null,"abstract":"<p><strong>Background: </strong>Cancer remains a global health challenge, and natural plant-based compounds show potential in prevention. Calligonum polygonoides Linn., a drought- and frost-resistant shrub native to the Thar desert, has adaptive resilience and ethnomedicinal applications. This study explores C. polygonoides stem extract (CPSE) against DMBA-induced two stage skin carcinogenesis in male Swiss albino mice.</p><p><strong>Methods: </strong>Skin carcinogenesis was induced in male Swiss albino mice using a single topical application of carcinogen DMBA (100 µg/animal), followed by the application of promotor croton oil (1% solution) thrice weekly as a tumour promoter, starting two weeks after DMBA initiation. CPSE was orally administered at a dose of 600 mg/kg body weight/day (100 µL per animal). Tumour incidence, yield, and burden were assessed, along with biochemical markers of oxidative stress in skin and liver tissues, including reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), lipid peroxidation (LPO), total protein, and vitamin C levels.</p><p><strong>Results: </strong>Mice treated with CPSE demonstrated a significant reduction in tumour incidence, yield, and burden compared to the carcinogen-treated control group. Additionally, CPSE administration significantly modulated oxidative stress and biochemical parameters in both skin and liver tissues. The CPSE-treated group exhibited decreased LPO levels and elevated antioxidant enzyme activities (GSH, SOD, and CAT), along with elevated total protein content and vitamin C levels, indicating enhanced systemic antioxidant defences.</p><p><strong>Conclusion: </strong>The findings of this study reveal the significant cancer chemo-preventive potential of C. polygonoides stem extract. Its ability to reduce tumour progression and modulate oxidative stress underscores its promise as a natural agent for cancer prevention. These results highlight C. polygonoides as a potential source for the development of cost-effective and sustainable cancer prevention strategies.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1831-1840"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Correlation of 17β-Estradiol in Blood and Estrogen Receptor α (ERα) and Estrogen Receptor β(ER β) in Tissue of Oral Squamous Cell Carcinoma.","authors":"Eesha Thakare, Minal Chaudhary, Madhuri Gawande, Amol Ramchandra Gadbail, Prajakta Zade","doi":"10.31557/APJCP.2025.26.5.1735","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1735","url":null,"abstract":"<p><strong>Objective: </strong>Evaluation and correlation of 17β-Estradiol(E2) in blood and Estrogen Receptor α (ERα) and Estrogen Receptor β(ER β) in tissue of four groups divided as normal control subjects (group I), active control subjects (group II), premalignant(leukoplakia) (group III) and OSCC patients (Group IV).</p><p><strong>Methods: </strong>Subjects were divided in four groups mentioned previously and evaluated individually for 17β-estradiol(E2) in blood and ERα & ER β in tissue. The blood samples were evaluated by chemiluminescence assay and tissues samples were evaluated by Real-Time PCR for tissue analysis. Analysis of variance (ANOVA) was applied for quantitative evaluation of variables in each group followed by TukeyB test. Pearson Correlation Coefficient was used to study the correlation between the variables. Survival analysis was calculated by Kaplan-Meier Survival Analysis.</p><p><strong>Results: </strong>The results are indicative of statistically significant increased levels of E2 in the 4 groups by analysis of variance (p value-0.0327) followed by TukeyB test with statistically significant difference between Group VI and I (sig value-0.008) and Group VI and II (sig value-0.029). The Pearson correlation coefficient demonstrated that the mean levels of Estradiol are positively correlated with mean levels of ER α (p value- 0.030). Results did not indicate an association between survival and expression of E2, ER α and ER β.</p><p><strong>Conclusion: </strong>The levels of E2 can be used as a marker in predicting the progression of disease from normal tissue not exposed to tobacco to normal tissue exposed to tobacco to premalignant to OSCC. The ERα in tissue is positively correlated with the increased levels of E2 in serum, so ERα expression in tissue along with E2 in serum could be used to identify the subsets of patients with higher risk of developing OSCC, especially those subjects with established tobacco habit but no appreciable change in oral mucosa.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1735-1743"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequence Variation in X-ray Cross Complimenting (XRCC4, XRCC5, XRCC6 and XRCC7) Genes and the Risk of Gastrointestinal Cancer in South-Western Maharashtra: A Hospital Based Case-Control Study.","authors":"Madhavi Narayan Patil, Parixit Jayprakash Bhandurge, Sandeep Sambhajirao Kadam, Kailas Dhondibhau Datkhile","doi":"10.31557/APJCP.2025.26.5.1571","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1571","url":null,"abstract":"<p><strong>Objective: </strong>A number of X-ray repair cross complementing group (XRCC) genes are found to be involved in the DNA repair by the repair of single strand breaks (SSBs). Variation in these genes may lead to variation in DNA repair capacity, thereby increasing the genetic susceptibility to numerous human cancers. Among the known genetic polymorphisms of the DNA repair genes, there are many functional genetic variants have been identified in the XRCC genes particularly XRCC4, XRCC5, XRCC6 and XRCC7 that shows the positive association with the multiple cancers including cancers of GI tract. Therefore, in the present study, polymorphic variants of XRCC4, XRCC5, XRCC6 and XRCC7 were chosen to be studied in association with gastrointestinal cancer susceptibility in the south western Maharashtrian population.  Methods: A total of 200 histologically confirmed cases of gastrointestinal cancer (GI) and 200 hospital-based controls were included in the study. The genotyping for XRCC4, XRCC5, XRCC6 and XRCC7 genes was carried out by polymerase chain reaction-restriction fragment length polymorphism.</p><p><strong>Results: </strong>We found that tobacco consumption in any form either smoking or chewing (OR = 4.03; 95% CI: 2.65-6.11) and alcohol drinking habit (OR = 4.45; CI: 2.15-9.22) is strongly associated with gastrointestinal cancer risk.  Similarly, data analysis of cases and control group showed that XRCC4.2 G1394T is significantly associated with GI cancer risk. Our studies also revealed that fewer repeats (1R/1R, 0R/0R) of XRCC5 in the promoter region were found to be associated with the increased risk of GI cancer. In case of XRCC7 6721G>T our findings suggest a strong association with development of GI cancer risk in south-western Maharashtrian population.  However, we did not find any association of polymorphic variants of XRCC4.1 cd247, XRCC4.5 Intron-7 and XRCC6 61C>G with GI cancer risk in the study population. However, multicentric studies with larger sample size are needed to substantiate the findings.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1571-1579"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}