Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Evaluating the Impact of Smoke-Free Policies in Jambi, Indonesia: A Mixed-Methods Approach.","authors":"La Ode Reskiaddin, Abdillah Ahsan, Adelina Fitri, Hubaybah Hubaybah, Fitria Eka Putri, Novi Reandy Sasmita","doi":"10.31557/APJCP.2025.26.5.1815","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1815","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the effectiveness of this policy and identifies socio-demographic factors influencing its acceptance and implementation.</p><p><strong>Methods: </strong>A convergent parallel design mixed-methods approach was employed, combining quantitative surveys and qualitative interviews. The study was conducted from January to March 2023. A total of 249 respondents including 9 policymakers and 240 public participants namely visitors to public places, workplaces, places of worship, children's play places, places of teaching and learning processes, health facilities and sports facilities. respondents were selected through purposive and accidental sampling. Quantitative data were analyzed using Mann-Whitney test and Spearman test is used in this study. Qualitative data coded and thematically analyzed.</p><p><strong>Result: </strong>The study revealed a low awareness of the smoke-free policy, with over 77.9% of respondents unaware of its existence. Despite this, more than 85% supported no-smoking signs and endorsed the policy. Education level emerged as a significant predictor of positive attitudes toward the policy (r = 0.239, p = 0.000). However, challenges in policy implementation, such as inadequate socialization, limited supervision, and budget constraints, were identified.  Conclusion: Implementation of the smoke-free area policy has not been effective. This was in accordance with the findings that there was low public awareness and education level as a predictor of positive attitudes toward the policy. The findings highlight the need for improved public health communication and enforcement strategies to enhance the effectiveness of smoke-free policies in Jambi.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1815-1821"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distressing Reality: Mumbai School Students Show Growing Interest and Familiarity with E-Cigarettes.","authors":"Tshering D Bhutia, Manasi Bawdekar, Kirti Gaur, Narayan Lad","doi":"10.31557/APJCP.2025.26.5.1719","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1719","url":null,"abstract":"<p><strong>Introduction: </strong>In the ever-evolving landscape of nicotine, electronic cigarettes (e-cigarettes) have gained popularity as devices that deliver nicotine and other chemicals to users in the form of aerosol without the need for combustion. The study examines increasing use of e-cigarettes among under-resourced adolescents in Mumbai's municipal and government schools.</p><p><strong>Methods: </strong>We used purposive sampling to recruit 72 students of Grade 8 and 9 from nine Mumbai municipal schools, enrolled in the Salaam Bombay programme, based on their willingness and ability to discuss e-cigarettes. We used thematic analysis to analyse interview data.</p><p><strong>Results: </strong>Results reveal that despite financial constraints, curiosity and misconceptions about safety these teens are drawn to e-cigarettes. Peer pressure and strategies to bypass bans exacerbate the trend. While the students are aware of ban on e-cigarettes, their understanding about the regulations remains limited. The 2019 Prohibition of Electronic Cigarette Act (PECA), while not entirely eradicating e-cigarette availability, has had a surprisingly positive impact. Informing the participants about legal consequences outlined in PECA triggered fear and a shift towards discreet consumption. This suggests that the law serves as an effective deterrent in curbing adolescent use. This research emphasizes the significance of PECA in reducing e-cigarette use among adolescents, advocating for its sustained and potentially amplified application.</p><p><strong>Conclusion: </strong>The study concludes that PECA alone is insufficient to address this complex issue. It calls for a comprehensive strategy, including targeted interventions that address peer pressure, online influences, and greater involvement of families to protect adolescents from dangers of e-cigarettes. A multi-faceted approach that includes education, legal enforcement, and community engagement is essential to combat this complex public health issue effectively.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1719-1725"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Nurse-Led Educational Intervention on the Knowledge, Perceptions and Uptake of Cervical Cancer Screening among HIV-Infected Women in Kenya.","authors":"Isaac Machuki Ogoncho, Sabina Wakasiaka, Irene Gacheri Mageto, Margaret Chege","doi":"10.31557/APJCP.2025.26.5.1591","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1591","url":null,"abstract":"<p><strong>Background: </strong>Health education influences the sociocultural health beliefs and enhances the decision making of women resulting in a change in their screening behavior. This study evaluated the impact of a nurse-led health education based on the Health Belief Model constructs on improving the knowledge, perceptions and the uptake of cervical cancer screening among HIV-infected women in Kisii County, Kenya.</p><p><strong>Methods: </strong>A 2-arm quasi-experimental design was employed in the HIV care clinics at Keumbu and Gucha sub-County hospitals in Kisii County, Kenya. The study population comprised of HIV-infected women aged between 15 and 49 years attending the two HIV care clinics. A sample size of 306 for each arm of the study was used. Systematic random sampling was used to select the 306 participants enrolled in each of the study arms. Socio-demographic and clinical characteristics, knowledge, perceptions and uptake of cervical cancer screening data among the HIV-infected women was collected at pre-test and post-test surveys.</p><p><strong>Results: </strong>We analyzed 566 participants (response rate 566/612, 92%) with 287 participants in the control arm and 279 participants in the intervention arm. There was a statistically significant difference in the mean scores of knowledge (p=0.001), perceived susceptibility (p=0.003), perceived severity (p=0.001), perceived barriers (p=0.001) and perceived self-efficacy (p=0.001) in the intervention arm compared to the control arm after the intervention. The proportion of participants screened significantly (p<0.001) increased from 16% to 57% in the intervention arm versus 7% to 9% in the control arm after the intervention.</p><p><strong>Conclusion: </strong>A nurse-led educational intervention in a hospital setting was effective in improving the knowledge and uptake of cervical cancer screening among HIV-infected women. The intervention partially improved their perceptions of cervical cancer and screening. Targeted health education can influence the uptake of cervical cancer screening among HIV-infected women.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1591-1597"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survivin (BIRC5) Gene Polymorphism (rs9904341) Is Associated with Cancer Risk: A Meta-Analysis.","authors":"Neha Malviya, Anam Khan, Ananyan Sampath, Sonu Singh Ahirwar, Jagat Rakesh Kanwar, Ashwin Kotnis","doi":"10.31557/APJCP.2025.26.5.1491","DOIUrl":"10.31557/APJCP.2025.26.5.1491","url":null,"abstract":"<p><strong>Introduction: </strong>Survivin (BIRC5) is an anti-apoptosis protein over expressed in most cancers and associated with poor clinical outcomes. We have provided an updated meta-analysis of -31G/C (rs9904341) gene polymorphism which is highly associated with cancer risk.</p><p><strong>Methodology: </strong>A comprehensive literature search in PubMed and Google Scholar databases was conducted. A total of 10472 cases and 12193 controls from 51 studies were included in this meta-analysis. This study was prospectively registered in PROSPERO, and sensitivity analysis, risk of bias analysis, and statistical analysis were performed. A pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to assess the strength of the association. All analyses were achieved using RevMan 5.4 software and Excel 2013 version.</p><p><strong>Results: </strong>The overall meta-analysis indicates that survivin gene polymorphism -31G/C (rs9904341) is highly associated with overall cancer risk in allelic (C vs. G, OR=1.25,95% CI= 1.15 to 1.37, P<0.00001), homozygous co-dominant (CC vs. GG, OR=1.53, 95% CI= 1.23 to 1.90, P=0.0001), heterozygous co-dominant (CC vs. CG, OR= 1.34, 95% CI= 1.18 to 1.52, P<0.00001), dominant model(CC+CG vs. GG, OR= 1.29, 95% CI= 1.14 to 1.46, P= <0.0001) and recessive model (CG+GG vs. CC, OR= 0.70, 95% CI= 0.61 to 0.81, P<0.00001). The stratified analysis revealed that the variant significantly increases the risk in the Asian population.</p><p><strong>Conclusion: </strong>-31G/C (rs9904341) polymorphism of the BIRC5 gene is associated with the risk of cancer in the Asian population. However, further large-scale clinical studies are required to re-evaluate this result in the future.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1491-1505"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Turnaround Times and Operational Efficiency in Radiology Services: Quality Improvement Study in Oman.","authors":"Badriya Al Qassabi, Rashid AlSukaiti, Shima Alajmi, Ahmed Sheikh Omar, Rawan Ibrahim, Aed Abdelqader Banibakr, Khalid Al-Baimani, Aref Zribi, Salim Nasser AlDhahli, Mohamad Majed, Mashan Mohammed AlGhaithi, Sara Qasim AlBalushi, Nabiha Said AlHasni, Sara Al Sheedi, Huda Shinoon Al-Awaisi, Nasr Al-Riyami, Omar Ayaad","doi":"10.31557/APJCP.2025.26.5.1709","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1709","url":null,"abstract":"<p><strong>Background: </strong>Turnaround time (TAT) in radiology reflects operational efficiency and impacts patient outcomes, particularly in time-sensitive fields like oncology, where timely diagnostics are essential for effective care.</p><p><strong>Purpose: </strong>This study aimed to evaluate the impact of targeted interventions on improving TAT and operational efficiency in radiology services in Oman.</p><p><strong>Methods: </strong>A pre- and post-intervention design was used to assess the effectiveness of implementing standardized operating procedures (SOPs), triage systems, staff training, and regular interdepartmental case discussions. Data were collected before and after the interventions to measure changes in TAT. Statistical analyses, including linear regression, were performed to assess trends in TAT performance over the intervention period.</p><p><strong>Results: </strong>The study observed a significant improvement in TAT, increasing from 88% in June 2023 to 95% in March 2024 (p < 0.05). A linear regression model demonstrated a steady monthly increase of 0.6% in TAT, with an R² value of 0.88, indicating that 88% of the variation in TAT was explained by the implemented interventions.</p><p><strong>Conclusion: </strong>The study confirms that structured workflow modifications, automation, and interdepartmental collaboration significantly enhance TAT and operational efficiency in radiology services, providing insights into sustainable healthcare improvements.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1709-1718"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Minimally Invasive Surgery for Colorectal Cancer: A Paradigm Shift.","authors":"Amirhosein Naseri, Mehdi Khosravi-Mashizi, Sepideh Soleymani, Ahmad Shirinzadeh-Dastgiri, Amirhossein Rahmani, Hossein Neamatzadeh","doi":"10.31557/APJCP.2025.26.5.1479","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1479","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1479-1481"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Insertion/Deletion Polymorphisms of MDM2, MCP-1 and VEGF with Esophageal Cancer Risk in North-West Indians: A Case - Control Study.","authors":"Deepanshi Mahajan, Vasudha Sambyal, Manjit Singh Uppal, Meena Sudan, Kamlesh Guleria","doi":"10.31557/APJCP.2025.26.5.1623","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1623","url":null,"abstract":"<p><strong>Background: </strong>The carcinogenesis process in esophageal cancer (EC), a highly heterogeneous and multifaceted disease, is influenced by both tumor angiogenesis and chronic inflammation pathways. Genetic variants in these pathways may affect the progression and development of EC, ultimately contributing to different susceptibilities to cancer among individuals.</p><p><strong>Methods: </strong>In this study, a total of 536 subjects were recruited, including 260 EC patients and 276 healthy individuals. The DNA was isolated from the blood samples of the participants using the standard phenol-chloroform method. The three insertion/deletion (ins/del) polymorphisms (VEGF-2549 18bp I/D, MDM2 40bp I/D, and MCP-1 14bp I/D) were screened using the Direct-polymerase chain reaction (PCR) genotyping method. The role of gene-environment interactions on EC risk was assessed using the Multifactor Dimensionality Reduction (MDR) software (version 3.0.2).</p><p><strong>Results: </strong>It was observed that the individuals carrying the II genotype and I allele of the VEGF-2549 18bp I/D polymorphism, as well as the carriers of the ID and DD genotypes and D allele of the MCP-1 14bp I/D polymorphism had a higher risk of developing EC. No association between the MDM2 40bp I/D polymorphism and EC risk was reported in this study. Genotype combination analysis revealed an increased EC risk in the carriers of the II-II-II genotype combination of the VEGF-2549 18bp I/D, MDM2 40bp I/D, and MCP-1 14bp I/D polymorphisms compared to those with other genotype combinations. The gene-environment interaction analysis also indicated a strong interaction between lifestyle factors and genetic polymorphisms in influencing EC risk.</p><p><strong>Conclusion: </strong>The present study concluded that the VEGF-2549 18bp I/D and MCP-1 14bp I/D variants were associated with EC risk in the North-west Indians.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1623-1631"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to Cervical Cancer Screening in India: Insights from National Family Health Survey-5 Data.","authors":"Shibaji Gupta, Atanu Dey, Sourav Kundu, Sharmistha Sinha Gupta","doi":"10.31557/APJCP.2025.26.5.1853","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1853","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer, one of the commonest malignancies, can be prevented and cured through early diagnosis. Screening plays an important role in its control strategy, and India has dedicated strategies to its implementation. However, screening uptake is low in India. We examined how sociocultural and financial factors affect Indian women's cervical cancer-screening uptake behaviour.</p><p><strong>Methods: </strong>Cervical cancer screening-uptake and relevant social, cultural, and financial data obtained from round-5 of the National Family Health Survey (NFHS) were used for analysis. We examined 399,039 eligible records to survey cervical cancer screening conduct and assessed the impact of sociocultural barriers on such conduct using logistic regression. Descriptive statistics were used to describe background data.</p><p><strong>Results: </strong>Most participants, aged 30-34 years, were uneducated, homemakers with bank accounts; mobile phone usage was limited, particularly in rural areas. One-third possessed health insurance, and approximately 10% had pre-diagnosed comorbidities. Only 2% underwent cervical cancer screening. Screening uptake was higher among older, educated, employed individuals with bank accounts, phone access, and media exposure. Mothers with more children and perceived constraints against healthcare seeking had lower uptake rates. Tobacco use, insurance, wealth, and media access had contrasting effects in rural and urban settings.</p><p><strong>Conclusion: </strong>Sociocultural and monetary factors have an unmistakable influence on cervical cancer screening uptake. Thus, aside from the continuous strengthening of the health system, our findings call for targeted mediations against misguided judgments and taboos alongside financial and social empowerment for better outcomes in India's cancer-screening policy.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1853-1861"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects and Disadvantages of Intraoperative Radiotherapy: A Systematic Review.","authors":"Yedil Kulanbayev","doi":"10.31557/APJCP.2025.26.5.1507","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1507","url":null,"abstract":"<p><strong>Objectives: </strong>The primary objective of this systematic review was to evaluate the efficacy, safety, and limitations of intraoperative radiotherapy (IORT) across different cancer types, with a focus on breast and head and neck cancers. The aim was to compare IORT with other radiotherapy techniques and assess its benefits and drawbacks in oncological settings.</p><p><strong>Methods: </strong>Eligibility criteria included clinical trials, meta-analyses, and systematic reviews involving at least 15 participants, focusing on the efficacy and safety of IORT in comparison to other radiotherapy methods. The literature search was conducted in Web of Science, Scopus, and PubMed databases using predefined keywords. A total of 60 studies were initially identified, with 44 meeting the inclusion criteria. The risk of bias was assessed using standardized tools, including the Cochrane Risk of Bias Tool for randomized studies. A qualitative synthesis was performed, integrating data on local control (LC), overall survival (OS), recurrence rates, and treatment-related complications.</p><p><strong>Results: </strong>Of the 60 studies identified, 46 were included in the final analysis. These studies focused on various cancers, with a particular emphasis on breast cancer and head and neck cancer. The synthesis revealed that IORT offers several benefits, such as reduced treatment time and better local control in specific patient populations. However, there were inconsistencies in outcomes depending on the radiation technique used, and long-term follow-up data were often lacking.</p><p><strong>Conclusion: </strong>The evidence is limited by study heterogeneity, potential bias, and the absence of long-term data in some cases. While IORT demonstrates promising results, particularly in terms of reducing treatment duration and preserving healthy tissue, further high-quality studies are needed to strengthen the evidence base and clarify the long-term outcomes of IORT in different oncological settings.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1507-1517"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Genetic Architecture of Obesity in Childhood Cancer Survivors: Insights from Recent GWAS Studies.","authors":"Maryam Yazdanparast, Maryam Vafapour, Rezvan Nezameslami, Alireza Nezameslami, Hossein Neamatzadeh","doi":"10.31557/APJCP.2025.26.5.1477","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1477","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1477-1478"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}