Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Determinants of Diagnostic Delays in Oral Squamous Cell Carcinoma: Insights from Demographic and Socio-Economic Factors.","authors":"Ameersheti Yuktha, Sharath Chaitanya Bandari, Shazia J H Fathima, Jayaraman Selvaraj, Vishnu Priya Veeraraghavan, Arun Kumar Dasari, Santosh R Patil","doi":"10.31557/APJCP.2024.25.11.3997","DOIUrl":"https://doi.org/10.31557/APJCP.2024.25.11.3997","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with high morbidity and mortality rates. Timely diagnosis is critical for improving patient outcomes; however, diagnostic delays remain a concern. Understanding the factors that contribute to these delays is essential for developing effective interventions. This cross-sectional study aimed to investigate the demographic, socioeconomic, and clinical determinants of diagnostic delay in patients with OSCC.</p><p><strong>Methods: </strong>This cross-sectional study included 226 patients with OSCC. Demographic data, including age, sex, marital status, education, and monthly household income, were collected. The time from symptom onset to definitive diagnosis was recorded. Stratified analysis and chi-square tests were conducted to assess the association between demographic and socioeconomic factors and diagnostic delays.</p><p><strong>Results: </strong>The mean diagnostic delay was 55.2 days, with 61.9% of the patients experiencing delays exceeding 40 days. Older age (>50 years), single marital status, lower educational level, and lower monthly income were associated with longer diagnostic delays (p < 0.05). Delays in biopsy sample collection also correlated with increased diagnostic delay (p < 0.05).</p><p><strong>Conclusion: </strong>Demographic and socioeconomic factors significantly influence diagnostic delays in patients with OSCC. Targeted interventions to address these disparities are crucial for improving early detection and enhancing patient outcomes.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3997-4003"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Epstein-Barr Virus Reactivation and Its Risk Factors in Allogeneic Hematopoietic Stem Cell Transplant Recipients.","authors":"Lekha Rani, Alka Khadwal, Jagdeep Singh, Shashi Anand, Manoj Kumar, Pankaj Malhotra, Ranjana Walker Minz","doi":"10.31557/APJCP.2024.25.11.3907","DOIUrl":"https://doi.org/10.31557/APJCP.2024.25.11.3907","url":null,"abstract":"<p><strong>Purpose: </strong>Epstein-Barr virus (EBV) reactivation in allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients can lead to significant complications including post-transplant lymphoproliferative disease. Despite progress in managing EBV reactivation in allo-HCT recipients, data on clinical characteristics and prognostic implications of EBV viral load remain limited. Here, we aim to evaluate the prevalence, identify risk factors, and assess the clinical implications of EBV-DNA positivity in allo-HCT recipients.</p><p><strong>Methods: </strong>A retrospective audit of laboratory records for EBV load monitoring in allo-HCT recipients during the period from 2021 to 2023 was performed. EBV viral load was assessed using quantitative PCR. The medical records were reviewed for clinical features, identifying risk factors, and prognostic impact of EBV-DNA positivity.</p><p><strong>Results: </strong>A total of 40 patients with a median age of 20.5 years were included. Patients were divided into two groups based on presence (>600 copies/mL) and absence of EBV-DNA. We observed EBV-DNA positivity in 16 (40%) patients with a median EBV viral load of 12,400 copies/ml. Patients with EBV-DNA positivity exhibited a higher incidence of acute graft versus host disease (p=0.039). Patients with EBV-DNA positivity tended to have poorer 1-year overall survival and disease-free survival, although the results did not reach statistical significance.</p><p><strong>Conclusion: </strong>Our data highlights the importance of monitoring EBV viral load in predicting the outcome in terms of overall survival in allo-HCT recipients. The development of GVHD has also surfaced as a significant element increasing the likelihood of EBV-DNA positivity. It is imperative to conduct further research and establish comprehensive protocols for the routine monitoring and management of EBV post-allo-HCT.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3907-3911"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of Apoptosis and Antiproliferative Activity of MCF-7 Human Breast Cancer Cells with Sonicated Aqueous Peel Extract of Punica granatum L. (Nimali sp.).","authors":"Udeshika Yapa Bandara, Preethi Soysa, Chamindri Witharana","doi":"10.31557/APJCP.2024.25.11.3967","DOIUrl":"https://doi.org/10.31557/APJCP.2024.25.11.3967","url":null,"abstract":"<p><strong>Background: </strong>The antioxidant and antiproliferative activities of various parts of the Punica granatum L. fruit (Nimali variety) on MCF-7 human breast cancer cells have been investigated.  The analysis of the effect on gene regulation and apoptosis induction compared to different extraction methods, was carried out highlighting the fruit's potential anticancer properties attributed to polyphenol-rich composition.</p><p><strong>Methods: </strong>This study analyzed alterations in radical scavenging capacity (RSC), phenol (TPC), and flavonoid contents (FC) of pomegranate fruit parts, and antiproliferative activity towards MCF-7 cancer cells using different extraction methods. Most effective peel extract/s were analyzed for total protein content, nitric oxide production, LDH, and Caspase 3 and 8 activities. RT-qPCR was performed with intact RNA to examine the apoptotic pathway and gene expression, and western blot analysis confirmed the presence of tumor suppressor protein/s.</p><p><strong>Results: </strong>The sonicated peel extract (SPL) exhibited the highest RSC, TPC, and FC. Fermented juice displayed higher RSC, TPC, and FC compared to fresh juice. Sonicated peel extract showed an IC50 value of 130±4.5 μg mL-1 against MCF-7 cells, while VERO (healthy) cells had values >1,000 μg mL-1. Sonication was identified as the most effective extraction method for the antiproliferative activity of pomegranate fruit. The study revealed that SPL induced apoptosis via the p21, p53-dependent, caspase 8 pathways, and caspase 3-independent mechanisms in MCF-7 cells.</p><p><strong>Conclusion: </strong>Findings emphasize the potential therapeutic effects of SPL in the antiproliferative effect of  MCF-7 cells by modulating caspase 8, p53, and p21-dependent pathways, without activating caspase 3.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3967-3976"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Awareness of Dental Students Regarding Human Papillomavirus and Oral Cancer in Saudi Arabia.","authors":"Anas B Alsalhani, Bassel Tarakji, Faisal Mehsen Alali, Faisal S Alhedyan, Nasser Abdulaziz Alduaydi, Muhannad Saleh Alshlwi, Abdullah Saad Alqahtahni, Nasser Raqe Alqhtani, Fahad Musa'ad Almutairi, Abdullah Bin Nabhan, Khalid Ayidh Alqahtani, Ali Robaian, Mohammed Noushad, Mohammad Zakaria Nassani","doi":"10.31557/APJCP.2024.25.11.3927","DOIUrl":"10.31557/APJCP.2024.25.11.3927","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the knowledge and awareness of dental students and interns in Saudi Arabia regarding human papillomavirus and oral cancer using a cross-sectional web-based survey.</p><p><strong>Materials and methods: </strong>A cross-sectional survey was undertaken to assess the knowledge of dental students and dental interns regarding oral cancer and awareness of human papillomavirus (HPV) in public and private dental schools in Saudi Arabia. The survey included 18 questions grouped into three sections. The responses were analyzed for variations between dental students and interns, among males and females, and those attending private or public colleges. The Chai-square test assessed the correlation between participants' demographic data and their knowledge/awareness of oral cancer and HPV.</p><p><strong>Results: </strong>A total of 451 dental students and dental interns responded. The results show that dental students at private and public dental schools in Saudi Arabia are generally knowledgeable regarding knowledge of oral cancer and awareness of human papillomavirus. The dental interns exhibited significantly superior knowledge compared to the undergraduate dental students (p<0.05), particularly in the areas of identifying the most common location of oral cancer and recognizing the signs and symptoms of oral cancer (76.5% versus 65.1% correct answers). The dental interns showed a significant difference and better awareness (p<0.05) than dental students regarding HPV having a relationship with AIDS and HPV causing common warts.</p><p><strong>Conclusion: </strong>Dental students and interns in this study presented a good but less than optimal knowledge and awareness regarding HPV and its prevention. Improving education courses and training for dental students in Saudi Arabia is crucial for improving their knowledge and awareness regarding oral cancer and HPV infection.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3927-3934"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Disparities in the Impact of Human Papillomavirus-Induced Lesions after 10 Years of HPV Vaccination Program in Brazil.","authors":"Adriana V Graca, Leila Cristina Soares Brollo","doi":"10.31557/APJCP.2024.25.11.3755","DOIUrl":"https://doi.org/10.31557/APJCP.2024.25.11.3755","url":null,"abstract":"<p><strong>Background and objective: </strong>Human papillomavirus (HPV) causes almost all cases of cervical cancer and its prevalence can be significantly reduced by vaccines. This study aimed to compare the prevalence of preneoplastic and neoplastic uterine cervix lesions in the cytology of Brazilian women aged 20-24 yr before and after the HPV vaccination campaign. The study also correlates these findings with the proportional coverage of first and second doses for this population.</p><p><strong>Methods: </strong>An ecological study was conducted and data from DATASUS were analyzed from 2020 to 2024. Data were collected from women aged 20-24 yr who had oncotic pap smears between 2020 and 2024, and the prevalence ratios (PRs) were calculated in relation to 2020.</p><p><strong>Results: </strong>Following the vaccination program, the prevalence rate of tests with HPV-induced lesions in Brazil and the north, southeast, and south regions decreased by 0.85, 0.75, and 0.83, respectively, in 2023. No significant reductions were observed in the northeast and central-west regions.</p><p><strong>Conclusion: </strong>Although the second dose had reduced coverage, HPV-induced lesions were observed to decrease in Brazil and the north, southeast, and south after 10 yr of the beginning of the vaccination program. Decrease in HPV-induced lesions over time after vaccination did not follow similar trend in the northeast or central-west regions as in other parts.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3755-3759"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytoprotective Properties of Turmeric Oil (Curcuma longa L.) on Fibroblast Cells.","authors":"Riris Istighfari Jenie, Anif Nur Artanti, Rumiyati Rumiyati, Dhania Novitasari, Yuni Kusumastuti, Manami Toriyama","doi":"10.31557/APJCP.2024.25.11.4005","DOIUrl":"10.31557/APJCP.2024.25.11.4005","url":null,"abstract":"<p><strong>Objective: </strong>Senescence is a cellular physiological process involved in cell aging. One factor that increases senescence is oxidative stress, which can be induced by hydrogen peroxide. Active compounds in turmeric (Curcuma longa) are classified as volatile and non-volatile. Major non-volatile compounds in turmeric are curcumin, dimethoxy curcumin, and bisdemethoxycurcumin bioactivities that have been widely explored. However, turmeric rhizome oil (TO) has limited reports on its bioactivity and constituents. This study aims to determine the potency of TO as cytoprotective against oxidative stress induced by hydrogen peroxide using the fibroblast cell lines (NIH-3T3 and HDF).</p><p><strong>Methods: </strong>We evaluated the cytotoxicity of TO using MTT assay, then evaluated its effect on cell senescence using SA-β-gal assay. The cellular reactive oxygen species (ROS) level was observed using DCFDA staining through flow cytometry. The turmeric volatile oil which was obtained by steam-water distillation was analyzed with a gas chromatography-mass spectrophotometry (GC-MS) to determine the chemical profile.</p><p><strong>Results: </strong>TO showed low cytotoxicity against HDF and NIH-3T3 cells, with IC50 values of over 100 µM. TO rescued cells from undergoing senescence and reduced ROS levels which were induced by hydrogen peroxide. The GC-MS spectra of the TO compound in positive ionization mode showed retention times of 23.56 and 26.20 minutes, corresponding to the ar-turmerone and turmerone compounds.</p><p><strong>Conclusion: </strong>These results indicated that TO has the potency as a cytoprotective agent in stress oxidative conditions.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"4005-4011"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing the Quality of Life (QOL) of Advanced Cancer Patients in Home-based Palliative Care (HBPC): A Systematic Review.","authors":"Ajay Kumar Kondeti, Kesava Ramgopal Adavikolanu, Soorej Balan Kaliyath, Yamini Marimuthu, Haveela Mary Nannepaga, Gopi Krishna Shyam, Shoban Babu Varthya","doi":"10.31557/APJCP.2024.25.11.3789","DOIUrl":"https://doi.org/10.31557/APJCP.2024.25.11.3789","url":null,"abstract":"<p><strong>Context: </strong>Despite the widespread recognition of the need for new palliative care models to better serve advanced cancer patients at the end of life, little importance is given to assessing the effectiveness of homecare models.</p><p><strong>Objective: </strong>This systematic review aims to summarize factors influencing the quality of life (QOL) of advanced cancer patients in home-based palliative care (HBPC) being adopted worldwide.</p><p><strong>Methods: </strong>Following the PRISMA guidelines, electronic databases such as MEDLINE, Cochrane, EMBASE, and Scopus databases from 2000 to February 2024 were systematically searched using predetermined search terms of \"quality of life\", \"home-based palliative care\" as well as \"advanced cancer\". Studies with less than ten subjects, scoping reviews, conference abstracts, and that adopted poorly validated QOL questionnaires were excluded.</p><p><strong>Results: </strong>Twenty-two (22) studies from both developed and developing countries were included in the narrative synthesis. 45.4% were cross-sectional, 27.2% were prospective cohort studies, 13.6% were retrospective cohort studies, and 18.1% were RCTs or quasi-experimental studies. Around 33 QOL factors were studied with 16 different types of QOL instruments. Advanced cancer patients who practiced spirituality, female gender, were married, had satisfaction with care, and preferred home as a place of death showed higher QOL scores. Older patients, aware of cancer diagnosis, poor performance status, high pain score, symptom distress, and psychological distress were associated with a poor QOL.</p><p><strong>Conclusion: </strong>Various factors affect QOL among cancer patients in HBPC. Hence it shows the importance of interventions to improve QOL and their rigorous implementation. With the widespread adoption of multi-disciplinary home care palliative programs, palliative care services to advanced cancer patients can be delivered readily which may be cost-effective.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3789-3797"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific Advances in Cancer Detection Using Raman Spectroscopy.","authors":"Gourav Kumar Jain, Rajni Verma, Arun Chougule, Bharti Singh","doi":"10.31557/APJCP.2024.25.11.3977","DOIUrl":"https://doi.org/10.31557/APJCP.2024.25.11.3977","url":null,"abstract":"<p><strong>Aim: </strong>The present study is focused to investigate the role of Raman spectroscopy (RM) for cancer detection.</p><p><strong>Methods: </strong>In this review, we explored a number of scientific databases including PubMed, Web of Science, Embase and Google Scholar for research studies on Raman spectroscopy for diagnosing cancer. We reported key outcomes of research studies conducted involving Raman spectroscopy for diagnosis of cancer and highlighting the potential of novel Raman spectroscopy for diagnosing cancer in our review.</p><p><strong>Results: </strong>Based on the available evidence it can be strongly concluded that Raman spectroscopy provide significant information for diagnosing cancer. Numerous comprehensive studies involving living cells in vitro, in-vivo animal models and ex-vivo human tissues pre-clinical Raman experiments are conducted on biological specimens for almost every type of cancer for diagnosing cancer demonstrating the potential for clinical use of Raman spectroscopy. Furthermore, the in-vivo Raman handheld probes are developed and experimentally used for real time detection of human breast and brain tumors with significant sensitivity and specificity. However, it will be important and challenging to explore relevant Raman biomarkers for other types of cancer as well, to distinguish cancer.</p><p><strong>Conclusion: </strong>Raman spectroscopy is an effective method and valuable tool in the field of cancer diagnostics. The Raman spectroscopy deserves a place for future in clinics for rapid cancer diagnostics.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3977-3986"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Sequencing of HER2-Positive Breast Cancer Mutations Revealed a Potential Association between PIK3CA and Trastuzumab Resistance.","authors":"Asmaa Mohamed Mekhamer, Marwa Hanafi Saied, Dalia Abd Elmoaty Elneily, Tarek Abdel Halim El-Fayoumi, Doaa Ibrahim Hashad","doi":"10.31557/APJCP.2024.25.11.4051","DOIUrl":"https://doi.org/10.31557/APJCP.2024.25.11.4051","url":null,"abstract":"<p><strong>Background: </strong>Different molecular subtypes, including HER2-positive, have been identified in breast cancer. The overexpression of HER2 triggers downstream signaling pathways such as the PI3K/AKT/mTOR pathway. Until recently, trastuzumab has been used as a single HER2-targeted therapy in Egypt. However, resistance to trastuzumab has been reported. Previous studies have demonstrated the genetic variants that affect the trastuzumab response. However in Egypt, few studies investigated molecular biomarkers such as p53 that might affect the trastuzumab response. Therefore, we aimed to extend the genetics workup of Her2 + BC to include important oncogenes and other vital cancer pathways.</p><p><strong>Methods: </strong>Formalin-fixed paraffin-embedded samples were collected from 24 HER2+ BC Egyptian patients, twelve patients in complete remission for 2 years or more from the start of trastuzumab and twelve resistant patients who relapsed or developed metastasis within 2 years from the start of trastuzumab. Somatic mutations in hotspot regions of 17 genes were further investigated using next-generation sequencing.</p><p><strong>Results: </strong>Among the total number of identified variants (106 variants), PIK3CA showed the most frequent variants, with more variants occurring in the resistant group than in the responsive group (P= 0.004). The frequency of PIK3CA mutations was greater in resistant patients than in responsive patients (P= 0.036). Additionally, there was a significant correlation between PIK3CA mutations and pathological complete response (pCR) (P=0.036). Most of PIK3CA variants in resistant patients were detected in exon 9 and 20. The PIK3CA variants His1047Tyr, Glu545Lys, His701Pro, Lys111Glu, Val344Gly and Tyr1021Cys were found only in the resistant patients, suggesting that they are associated with trastuzumab resistance.</p><p><strong>Conclusion: </strong>PIK3CA variants were more frequent in resistant HER2+ BC patients than in responsive patients, with a significant correlation between PIK3CA mutation and a lower pCR rate. PIK3CA variants within exon 9 and 20 (such as Glu545Lys and His1047Tyr respectively) were associated with trastuzumab resistance.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"4051-4059"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet Psychosocial Needs and Quality of Life of Young Women with Breast Cancer: A Scoping Systematic Review.","authors":"Shaza Hasan, Keng Sheng Chew","doi":"10.31557/APJCP.2024.25.11.3781","DOIUrl":"10.31557/APJCP.2024.25.11.3781","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis and treatment of breast cancer are very distressing for young women and can result in a lot of unmet psychosocial needs and a lower quality of life.</p><p><strong>Objective: </strong>Although unmet psychosocial needs in young women with breast cancer can negatively impact their quality of life, these needs have not been systematically reviewed. The primary objective of this scoping review was to identify the categories of unmet psychosocial needs among young women with breast cancer. The secondary objective was to examine the relationship between these unmet psychosocial needs and their quality of life.</p><p><strong>Methods: </strong>Five electronic databases (MEDLINE from the National Library of Medicine, Cumulative Index of Nursing and Allied Health Literature (CINAHL), SCOPUS, Web of Science WOS, and Google Scholar), as well as reference lists of relevant literature were systematically searched to identify the relevant literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews.</p><p><strong>Results: </strong>From an initial yield of 2505 articles, 30 articles were included and analyzed. The results identified 13 main domains of unmet psychosocial needs among young women with breast cancer: information needs, psychological needs, physical/symptoms needs, fear of recurrence and spreading, identity-related needs, social needs, sexual needs, social support, financial support, practical needs, spiritual needs, communication-related issues with health care providers, and coping needs. Data were extracted and summarized in a narrative synthesis.</p><p><strong>Conclusion: </strong>Ongoing assessment of informational needs and a clear understanding of the relationship between unmet psychosocial needs and quality of life are essential for healthcare providers to develop robust support systems for young women with breast cancer.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3781-3788"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}