Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Single Nucleotide Polymorphisms in APE1, hOGG1, RAD51 Genes and Radiotherapy Induced Toxicity among Head and Neck Cancer Patients: Comment.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.31557/APJCP.2025.26.4.1105","DOIUrl":"10.31557/APJCP.2025.26.4.1105","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1105-1106"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Angiogenic and Anti-Proliferative Activities of 5-Bromo-N-(2,5-Dioxopyrrolidin-1-Yl)-1H-Indole-2-Carboxamide.","authors":"Hayder B Sahib, Ahmed K Aldhalmi, Omeed M Hassan, Ammar A Razzak Mahmood, Lubna H Tahtamouni, Zainab Khalid Ali","doi":"10.31557/APJCP.2025.26.4.1219","DOIUrl":"10.31557/APJCP.2025.26.4.1219","url":null,"abstract":"<p><strong>Background: </strong>Angiogenesis has long been a key focus for drug designers aiming to develop therapies targeting diseases associated with this physiological process. A newly synthesized compound from the University of Baghdad was evaluated for its ability to inhibit blood vessel growth. The objective of this study was to investigate the anti-angiogenic activity of 5-bromo-N-(2,5-dioxopyrrolidin-1-yl)-1H-indole-2-carboxamide using an ex vivo rat aorta model.</p><p><strong>Methods: </strong>An anti-angiogenesis assay was employed to assess the dose-response relationship and to determine the concentration that inhibits 50% of blood vessel growth (IC50). The anti-proliferative effect on endothelial cells was assessed using the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Additionally, the free radical scavenging activity of the compound was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The anti-proliferative activity against the A549 lung cancer cell line was also investigated.</p><p><strong>Results: </strong>The compound demonstrated significant anti-angiogenic activity with an IC50 of 15.4 µg/mL. The IC50 on the HUVEC cell line was 5.6 µg/mL. Its free radical scavenging activity was measured at 99.6 µg/mL. Furthermore, the compound significantly inhibited the proliferation of the A549 lung cancer cell line, with an IC50 of 14.4 µg/mL.</p><p><strong>Conclusion: </strong>The findings suggest that 5-bromo-N-(2,5-dioxopyrrolidin-1-yl)-1H-indole-2-carboxamide possesses notable anti-angiogenic activity and a significant anti-proliferative effect on HUVEC cells, potentially linked to its strong free radical scavenging capacity. Moreover, it effectively inhibited the proliferation of lung cancer cells.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1219-1223"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Tobacco Control Research: Commentary on Smoking Initiation in Jordan.","authors":"Sabyasachi Shukla, Sonam Jalewa Agarwal, Puravi Dubey, Pratap Kumar Jena","doi":"10.31557/APJCP.2025.26.4.1107","DOIUrl":"10.31557/APJCP.2025.26.4.1107","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1107-1108"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Status of Implementation of Cancer Screening Programme in India: A Review of Policies and Practice.","authors":"Kunal Oswal, Kumar Gaurav, Akash Pradhan, Venkataramanan Ramachandran, Paul Sebastian, Partha Basu","doi":"10.31557/APJCP.2025.26.4.1117","DOIUrl":"10.31557/APJCP.2025.26.4.1117","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer is becoming a leading cause of death and disability across the globe and India too has a high burden of disease with poor outcomes. The national cancer screening program has been rolled out since 2010 but has not yielded the desired results so far. The objective of the present review is to perform an analysis of the strengths and weaknesses of the cancer screening component of the National Program - Non Communicable Disease (NP-NCD) program based on a scoping review of policies, organization, and status of implementation of the program at the primary and secondary levels and also on observations from field experience of the program managers and other health professionals from selected states in India.</p><p><strong>Methods: </strong>A mixed methodology was used to document the status of the implementation of the ongoing cancer screening program in India. The methodology included a literature review, observation of the frontline health professionals and an in-depth discussion with those in managerial capacity at the health facilities or the screening program.</p><p><strong>Results: </strong>Cancer screening is a complex public health initiative requiring a highly organized framework for effective implementation. Although India has implemented a comprehensive Non-Communicable Disease (NCD) screening program since 2010, the results have been minimal. The latest National Family Health Survey (NHFS 2019-21)  reported that among the female population aged 30 to 49 years, only 1.9% and 0.9%  were ever screened for cervical cancer and breast cancer respectively. The proportion of 30-49 year-old males reported to be ever screened for oral cancer was only 1.2%. Tamil Nadu and Kerala showed significantly better screening participation compared to other states in the country.</p><p><strong>Conclusion: </strong>Cancer screening is a complex public health initiative requiring a highly organized framework for effective implementation. The Ayushman Bharat comprehensive primary healthcare service package and plan to deliver cancer screening through the Health and Wellness centers (AB-HWCs) is a good opportunity to revamp the program.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1117-1128"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Therapeutic Potential of Oxo berberine Compound in Arcangelisia flava Root Extract for Breast Cancer Treatment: Metabolite Profiling, Pharmacological Network Analysis, and In Silico and In Vitro Evaluation.","authors":"Roihatul Mutiah, Syayida Roisatus Zahiro, Torikhotul Jauharotun Nafisah, Rahmi Annisa, Arief Suryadinata, Alif Firman Firdausy, Sukardiman Sukardiman","doi":"10.31557/APJCP.2025.26.4.1313","DOIUrl":"10.31557/APJCP.2025.26.4.1313","url":null,"abstract":"<p><strong>Objective: </strong>Chemotherapy treatments for breast cancer often entail side effects and drug resistance. Arcangelisia flava root extract (AFRE) shows potential as an anti-cancer agent, but understanding its compounds and mechanisms against breast cancer remains limited. This study aims to identify potential compounds in AFRE and shed light on its actions against breast cancer.</p><p><strong>Methods: </strong>Compounds in AFRE were identified via LC-MS/MS. ADMET software evaluated absorption and bioavailability. Molecular anti-cancer mechanisms were predicted using network pharmacology with tools like Cytoscape, GeneCards, Disgenet, STRING, GO, KEGG pathways, and SRplot. Interaction between oxo berberine and key breast cancer receptors was analyzed through molecular docking with PyRx Autodock Vina and Biovia Discovery Studio. Cytotoxicity was assessed using the MTT method on T47D cells, and flow cytometry evaluated the potential to inhibit the cell cycle and induce apoptosis.</p><p><strong>Result: </strong>A total of 16 active compounds were identified through LC-MS/MS, with oxo berberine being the most abundant at 41.43%. Importantly, it exhibited anti-cancer properties by interacting with 84 genes and affecting 13 signaling pathways related to breast cancer. We found that oxo berberine had a stronger negative binding affinity with PI3KCA, TP53, BCL2, CDK1, EGFR, and MAPK14 than the native ligand, which was supported by molecular docking results. In vitro validation supported these results even more, showing that AFRE treatment caused more T47D cells to die (36.6%) than the control and doxorubicin, as well as more cells to gather in the G1 phase.</p><p><strong>Conclusion: </strong>In summary, this evidence highlights the potent anti-cancer effects of oxo berberine in AFRE against breast cancer.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1313-1328"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of rs2294008 (PSCA) Gene polymorphism in Urothelial Bladder Cancer of South Indian Population.","authors":"Saziya R Bidi, Shridhar C Ghagane, Shadab Rangrez, Rajendra Nerli","doi":"10.31557/APJCP.2025.26.4.1441","DOIUrl":"10.31557/APJCP.2025.26.4.1441","url":null,"abstract":"<p><strong>Background: </strong>Urothelial Bladder cancer (UBC) is a significant health problem worldwide. Prostate stem cell antigen (PSCA) gene has been reported earlier in Genome Wide Association Study (GWAS) for the risk of UBC. It is highly expressed in urothelial bladder tumours and considered to be involved in the cell proliferation inhibition and/or cell-death induction activity. The study aims to investigate PSCA gene as a possible marker for the diagnosis and prognosis of urothelial bladder cancer.</p><p><strong>Patients and methods: </strong>We genotyped PSCA rs2294008C/T gene by Real Time Taqman® probes to evaluate the risk of UBC in histologically confirmed bladder tumour patients 107 and healthy controls 105 (age and gender matched) in a hospital-based setting from South Indian population. Statistical analysis was carried out using (SPSS ver 22.0 Armonk NY, USA).</p><p><strong>Results: </strong>The heterozygous CT genotype showed increased significance risk to UBC with PSCA rs2294008 C/T having 2.77 folds risk (p<0.0001). The variant allele T was also significantly associated with UBC risk (p<0.0001; OR=3.349) for PSCA rs2294008C/T. A significant UBC risk was noted when risk was evaluated with tumor-grade-stage level for PSCA rs2294008C/T with heterozygous CT genotype for high grade tumours (p<0.001; OR=1.984). The smoking factor was significantly modulated with the risk of UBC in patients with heterozygous CT genotype (p<0.0001) for PSCA rs2294008C/T gene polymorphism. Urothelial Bladder cancer patients receiving BCG treatment showed no significant association with genotype of PSCA.</p><p><strong>Conclusions: </strong>The present study has unveiled a complex intervention of PSCA rs2294008C/T conferring a higher risk of UBC risk among smokers in South Indian population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity. These findings suggest that the PSCA rs2294008C/T polymorphism of PSCA gene could be served as a biomarker for genetic susceptibility to bladder cancer in Indian populations.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1441-1446"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian Tumors during Pregnancy and Adverse Pregnancy Outcome: A Retrospective Analysis.","authors":"Kittiya Ritta, Wiyada Luangdansakul, Buppa Smanchat, Kornkarn Bhamarapravatana, Komsun Suwannarurk","doi":"10.31557/APJCP.2025.26.4.1329","DOIUrl":"10.31557/APJCP.2025.26.4.1329","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of ovarian tumor in pregnancy.</p><p><strong>Materials and methods: </strong>A retrospective descriptive study was conducted using electronic data from Obstetrics and Gynecology Department at Bhumibol Adulyadej Hospital (BAH), Royal Thai Air Force, Thailand recorded between January 2012 and December 2022. The participants were patients diagnosed with ovarian tumors during pregnancy (OTP) within the study period. Demographic characteristics, histopathological findings, ultrasonography results and pregnancy outcomes were recorded.</p><p><strong>Results: </strong>A total of 190 OTP cases were identified among 41,842 pregnant women. One hundred twenty-six OTP cases underwent surgery during pregnancy. The mean age of the participants was 29.6 years. The prevalence of ovarian tumors was 4.5(190/41,842) in 1000 pregnancies. Malignant ovarian tumors accounted for 0.14% (2/126). Histopathological analysis revealed that germ cell ovarian tumors and common epithelial ovarian tumors were found in 50.79% (64/126) and 49.2% (62/126) of cases, respectively. Most germ cell ovarian tumors were mature cystic teratomas, which were found in 98% (63/64) of cases. One-third (32/126) of the OTP cases underwent surgery during the second and early third trimesters. Fetal loss following surgery occurred in 18.75% (6/32) of cases. Adnexectomy performed with cesarean delivery and after vaginal delivery occurred in 93 and 1 cases, respectively. Symptomatic OTP leading to emergency surgery was observed in 6.84% (13/190) of cases.</p><p><strong>Conclusion: </strong>The prevalence of OTP was 4.5 per 1,000 pregnant women. Fetal loss during surgery in pregnancy occurred in 18.75%. Mature cystic teratoma was the common histopathological finding.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1329-1333"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The DNA Methylation is Involved in Liver Cancer Metastasis via Regulation of E- cadherin Gene.","authors":"Asmahan S Kabel, Shaden M Hanafy, Mohamed F Elshal, Talaat Z Ibrahim, Hany Khalil","doi":"10.31557/APJCP.2025.26.4.1371","DOIUrl":"10.31557/APJCP.2025.26.4.1371","url":null,"abstract":"<p><p>Over 90% of primary liver tumors are hepatocellular carcinomas (HCCs). In mammalian cells, chromatin remodeling and transcription regulation are significantly influenced by DNA methylation. Many cancers demonstrate both generalized DNA hypomethylation and localized DNA hypermethylation. Epithelial Cadherin (E-cadherin), a critical molecule in cell adhesion and cancer progression, is involved in these processes. This study aimed to investigate the biological role of DNA methyltransferase 1 (DNMT1) in HCC and its association with E-cadherin gene expression in HCC development. The study included 120 HCC patients from Egypt and 25 healthy individuals. Peripheral blood samples were collected from both groups, and quantitative real-time PCR was utilized to measure the expression levels of the E-cadherin and DNMT1 genes. All participants underwent a comprehensive medical history review and clinical examination. Additionally, the patients had laboratory tests, including serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), α-fetoprotein (AFP), albumin, serum creatinine, total leukocyte count (TLC), and platelet count. The results revealed significantly higher levels of these biochemical markers in the HCC group compared to the control group (P values < 0.005). Notably, DNMT1 expression was significantly higher in HCC samples compared to those from healthy controls. In contrast, the expression of E-cadherin was significantly reduced in the HCC group. Furthermore, our findings revealed that the relative gene expression of DNMT1 was negatively correlated with the relative gene expression of E-cadherin, AFP, and tumor size, while E-cadherin expression was negatively correlated with AFP and tumor size. These results suggest that DNMT1 may play a vital role in regulating E-cadherin expression, which could influence the migratory behavior of HCC cells.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1371-1378"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Survival Trends of Cervical Cancer in Khon Kaen, Thailand.","authors":"Jakkree Pasane, Kan Sriwatana, Kuntawit Krasairsom, Napatsanun Suwunnapang, Chalongpon Santong, Bandit Chumworathayi","doi":"10.31557/APJCP.2025.26.4.1393","DOIUrl":"10.31557/APJCP.2025.26.4.1393","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and report the incidence and survival trends of cervical cancer in Khon Kaen, Thailand, during 1991-2020.</p><p><strong>Methods: </strong>A retrospective study was conducted by using the electronic cancer registry database of Khon Kaen province population. Joinpoint regression model was used to analyze the Age-Standardized Incidence Rate (ASR) and the incidence trend graph was built. Overall Observed Survival (OS) was analyzed by Kaplan Meier method and the survival trend graph was built similarly.</p><p><strong>Result: </strong>During 1991-2020, 3,071 cervical cancer patients were found in Khon Kaen. Their mean age was 51.7 year-old. The ASR had decreased from 13.51 (95%CI: 10.67-16.35) per 100,000 women-year in 1991 to 7.63 (95%CI: 5.93-9.33) per 100,000 women-year in 2020. This trend was consistent with the country's and international trends. The highest incidence was found in 1993, which was 17.73 (95%CI: 14.65-20.81), and the lowest incidence was found in 2016, which was 5.7 (95%CI: 4.30-7.10) per 100,000 women-year. However, the 5-year OS was 48.37% (95%CI: 46.49-50.22), which was a constant trend. At the beginning in 1991-1995, the OS was 40.31% (95%CI: 35.43-45.12), and at the end in 2016-2020, the OS was 40.46% (95%CI: 34.59-46.23). These were very similar.</p><p><strong>Conclusion: </strong>In Khon Kaen, Thailand, during 1991-2020, the cervical cancer incidence (ASR) trend was decreasing, while the cervical cancer survival (OS) trend was constant. WHO elimination of cervical cancer initiative target should be reached by 2030.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1393-1400"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Efficacy of Citrullus Colocynthis Oil as a Promising Agent in Suppressing Human Lung Adenocarcinoma A549 Cells.","authors":"Ahmed Naeem Al-Khammas, Ali Abd Allateef Al-Ali","doi":"10.31557/APJCP.2025.26.4.1243","DOIUrl":"10.31557/APJCP.2025.26.4.1243","url":null,"abstract":"<p><strong>Objective: </strong>Lung adenocarcinoma is the most common respiratory system tumor worldwide. This type of tumor facing challenges such as multidrug resistance and low selectivity.  The need for alternative therapeutic strategies motivates researchers to discover new approaches for tumor treatments. Previous studies indicate that phytochemicals may inhibit cancer development and progression.</p><p><strong>Methods: </strong>Citrullus colocynthis oil extraction was used as phytochemical therapy to inhibit cell proliferation, invasion, and enhanced cell death. The extracted oil was analyzed using GC-mass, and cell viability was assessed by MTT, apoptotic, and wound healing assay. In this study, human lung adenocarcinoma A549 cancer cell lines and human breast epithelial HBL-100 normal cell lines were used to test the efficiency of Citrullus colocynthis oil extraction on inhibiting lung cancer.</p><p><strong>Result: </strong>The results demonstrated a significant cytotoxic effect of Citrullus Colocynthis oil extraction against cancer cells, with no observed effects on normal cells.</p><p><strong>Conclusion: </strong>Phytotherapy may suppress human lung adenocarcinoma A549 cancer cell lines and offer a new strategy for future cancer therapy.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 4","pages":"1243-1251"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}