Anticancer Efficacy of Citrullus Colocynthis Oil as a Promising Agent in Suppressing Human Lung Adenocarcinoma A549 Cells.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-04-01 DOI:10.31557/APJCP.2025.26.4.1243

Ahmed Naeem Al-Khammas, Ali Abd Allateef Al-Ali

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引用次数: 0

Abstract

Objective: Lung adenocarcinoma is the most common respiratory system tumor worldwide. This type of tumor facing challenges such as multidrug resistance and low selectivity. The need for alternative therapeutic strategies motivates researchers to discover new approaches for tumor treatments. Previous studies indicate that phytochemicals may inhibit cancer development and progression.

Methods: Citrullus colocynthis oil extraction was used as phytochemical therapy to inhibit cell proliferation, invasion, and enhanced cell death. The extracted oil was analyzed using GC-mass, and cell viability was assessed by MTT, apoptotic, and wound healing assay. In this study, human lung adenocarcinoma A549 cancer cell lines and human breast epithelial HBL-100 normal cell lines were used to test the efficiency of Citrullus colocynthis oil extraction on inhibiting lung cancer.

Result: The results demonstrated a significant cytotoxic effect of Citrullus Colocynthis oil extraction against cancer cells, with no observed effects on normal cells.

Conclusion: Phytotherapy may suppress human lung adenocarcinoma A549 cancer cell lines and offer a new strategy for future cancer therapy.

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瓜精油对人肺腺癌A549细胞的抑癌作用

目的：肺腺癌是世界上最常见的呼吸系统肿瘤。这种类型的肿瘤面临着多药耐药和低选择性等挑战。对替代治疗策略的需求促使研究人员发现肿瘤治疗的新方法。先前的研究表明，植物化学物质可能抑制癌症的发生和发展。方法：采用香瓜油提取物作为植物化学疗法，抑制细胞增殖、侵袭，促进细胞死亡。采用GC-mass分析提取油，MTT、凋亡和伤口愈合实验评估细胞活力。本研究以人肺腺癌A549细胞系和人乳腺上皮细胞HBL-100正常细胞系为实验材料，检测香瓜油提取物对肺癌的抑制作用。结果：瓜蒌油提取物对肿瘤细胞有明显的细胞毒作用，对正常细胞无明显影响。结论：植物疗法可能抑制人肺腺癌A549细胞系，为未来的癌症治疗提供了新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.