Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Development of Mobile Application Based System for Improving Population Based Cancer Screening by Community Health Workers.","authors":"Roopa Hariprasad, Manjeet Singh Chalga, Ashwini Kedar, Vipin Kumar, Subhadra Goala, Ritesh Tapkire, Ravi Kannan","doi":"10.31557/APJCP.2025.26.1.127","DOIUrl":"10.31557/APJCP.2025.26.1.127","url":null,"abstract":"<p><strong>Objective: </strong>Cancer remains a leading cause of morbidity and mortality globally, with India experiencing a significant cancer burden. Effective population-based cancer screening is crucial for early detection and reduction of cancer-related deaths. This study aims to develop a mobile application-based Cancer Screening and Surveillance System (CSMS) to enhance the efficiency and effectiveness of population-based cancer screening by community health workers (CHWs).</p><p><strong>Methods: </strong>An applied research approach was employed, integrating traditional cancer screening procedures with a newly developed mobile application system. The CSMS includes an Android-based mobile application and a web portal designed for real-time data collection, monitoring, and rapid referral of screen-positive cases. The system was piloted in the Cachar district of Assam and training sessions were conducted to equip CHWs with traditional cancer screening procedures and the necessary skills to utilize the mobile application for cancer screening.  199 CHWs were trained and screened eligible population of 73,630 individuals.</p><p><strong>Results: </strong>The mobile application facilitated efficient data collection and synchronization with a central server, enabling timely referrals and follow-ups. The system supported comprehensive data management, ensuring patient privacy and data security. The pilot implementation demonstrated improved screening coverage and streamlined referral processes, highlighting the system's potential to enhance cancer screening programs.</p><p><strong>Conclusion: </strong>Mobile application-based Cancer Screening and Surveillance System provides a cost-effective and robust solution for population-based cancer screening. The developed system can improve data accuracy, facilitate timely referral and aid in early detection of cancer. Further studies should be conducted to evaluate the impact of the developed system and its scalability in more diverse settings.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"127-136"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Tumor-Associated Neutrophils in Early Luminal HER2-Negative Breast Cancer Progression.","authors":"Evgenii I Zakurdaev, Zurab A Bagateliya, Konstantin S Titov, Ekbal Elkhouli, Nikita P Chizhikov, Daria V Kharina","doi":"10.31557/APJCP.2025.26.1.207","DOIUrl":"10.31557/APJCP.2025.26.1.207","url":null,"abstract":"<p><strong>Objectives: </strong>To study the predictive role of tumor-associated neutrophils in early luminal HER2-negative breast cancer.</p><p><strong>Materials and methods: </strong>This is a retrospective study conducted on 60 women cases aged from 31 to 79 years underwent surgery for luminal HER2-negative ductal breast cancer in tertiary care cancer centre. We first estimated basic morphological signs: tumor size, tumor grade (by Nottingham Histologic Score), tumor infiltrating lymphocytes (TILs), Lymphovascular invasion, hormonal receptors status, proliferative index, and regional lymph nodes metastasis. The expression of intratumoral neutrophils was studied by CD15 immunohistochemistry which was performed using tissue microarrays. The total number of intratumoral neutrophils, were counted in 5 high-power fields.</p><p><strong>Results: </strong>According to the Nottingham histologic score system, grade I cases were detected in 10 cases (16%), grade II in 34 cases (57%), and grade III in 16 cases (27%). Lymphovascular invasion was determined in 23 cases (38%), and perineural invasion in 14 cases (23%). Number of TILs varied from 0 to 14 (counted in 5 HPF) and averaged 4.2±0.5. Luminal A tumor phenotype was detected in 35 cases (58%), and luminal B HER2-negative in 25 cases (42%). Nineteen (32%) women had metastases in regional lymph nodes (N+). The number of tumor microenvironment neutrophils in luminal HER2-negative breast carcinomas ranged from 1 to 10 (counted in 5 HPF) with an average value of 2.7±0.4. High tumor-associated neutrophils concentration significantly correlated with tumor size (<5mm and >20mm) with p=0.05, high grade (p=0.01), high proliferative index ((r=0.67; p=0.05), TILs (p=0.05), Lymphovascular space invasion (p=0.01)and positive regional lymph nodes metastasis (p=0.001), but not perineural invasion (p=0.1) and also, did not correlate with the expression of estrogen (r=0.18) and progesterone (r=0.14) receptors.</p><p><strong>Conclusion: </strong>Tumor-associated neutrophils strongly predict a worse prognosis in early luminal HER2-negative breast cancer.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"207-213"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Oral Rub and Rinse Technique for Oral Cancer Screening: Results from a Community-based Program in an LMIC.","authors":"Audrey Madonna DCruz, Pushparaja Shetty, Urvashi Ashwin Shetty, Pandyanda Nanjappa Dechamma, Vinayak Kamath, Shaila M Bhat, Anirban Chakraborty","doi":"10.31557/APJCP.2025.26.1.91","DOIUrl":"10.31557/APJCP.2025.26.1.91","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer screening programs can aid in the early identification of potentially malignant oral lesions. The objective of the present study was to evaluate the effectiveness of the Oral Rub and Rinse (ORR) technique as an oral cancer screening tool and to test its potential in detecting genetic alterations in exfoliated cells obtained through ORR.</p><p><strong>Methods: </strong>The screening programs were conducted in rural Dakshina Kannada and Udupi districts in Karnataka. All adults with red and/or white lesions were included in the study. Samples were collected using the ORR technique, and smears were prepared. In parallel, Conventional Exfoliative cytology (CEC) smears were also prepared.  ORR samples and tissue biopsy were obtained from Classes III, IV, and V cases. Seven Oral Squamous Cell Carcinoma (OSCC) tissue samples, 7 OSCC ORR samples, and five control samples were randomly selected. The presence of single nucleotide polymorphisms (SNP) in USP9X and DDX3X were checked through Sanger sequencing. Diagnostic agreement between the ORR and CEC technique was assessed using the McNemar test.</p><p><strong>Results: </strong>A total of 2514 individuals were screened, of which 217 patients with red/ white lesions were included in the study. There was good agreement between the exfoliative cytology and ORR. The sensitivity of the ORR was 84.54%, specificity 85.83%, positive predictive value 82.83%, and negative predictive value 87.29%. Overall, the diagnostic accuracy of the ORR technique was 85.25%. Although none of the samples showed the presence of target SNPs in USP9X and DDX3X genes, the utility of the ORR technique as a tool for conventional and molecular studies was confirmed.</p><p><strong>Conclusion: </strong>The present study highlights the usefulness of the ORR technique as an effective tool in population-based oral cancer screening programs. Further, the cells obtained from ORR are an excellent source of DNA and can potentially identify genetic alterations with high accuracy.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"91-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Epidemiology of Human Papillomavirus Screening Coverage in Mexico, 2013-2019.","authors":"Oscar Alejandro Palacios Rodríguez, Miguel Galarde López, Carlos Quezada Sánchez, Antonio Reyna Sevilla","doi":"10.31557/APJCP.2025.26.1.215","DOIUrl":"10.31557/APJCP.2025.26.1.215","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to assess the coverage of a Human Papillomavirus (HPV) screening program for each of the 32 federal states of Mexico, as well as the spatial patterns for HPV infections from 2013 to 2019.</p><p><strong>Methods: </strong>We conducted an exploratory, ecological study on data from a national health program in Mexico during 2013-2019. Adjusted rates per 100,000 females aged 25-64 years were estimated and georeferenced at the national and state level to assess the coverage of the screening program and positive detections of HPV infections. Cluster analysis was used to identify the location, magnitude, and trends of spatial patterns (p <0.05) by year and state.</p><p><strong>Results: </strong>2,529,819 screening tests for HPV detection were analyzed (2013-2019). A prevalence of HPV positivity of 11.1% (n= 228,582) was estimated. The number of HPV screening tests decreased from 2,835.4 (2013) to 0.8 (2019) per 100,000 females aged 25 to 64. HPV detection also showed a downward trend. A cluster (p <0.05) associated with a higher probability of detecting HPV infections was identified, comprised of territorially close states.</p><p><strong>Conclusion: </strong>A decreased coverage of the HPV screening program and geographic differences were identified, suggesting that the existing strategies to prevent and detect HPV infections to accelerate cervical cancer elimination in Mexico need to be further reconsidered.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Five Pathological Tumor Regression Grading Systems for Rectal Cancer Following Chemoradiation: Correlation Coefficient and Intra-Rater Reliability.","authors":"Sahaphol Anannamcharoen, Chinakrit Boonya-Ussadorn, K Satayasoontorn, Thirayost Nimmanon","doi":"10.31557/APJCP.2025.26.1.199","DOIUrl":"10.31557/APJCP.2025.26.1.199","url":null,"abstract":"<p><strong>Objective: </strong>To determine the correlation among five different types of tumor regression grading (TRG) systems. Test-retest reliability analyses were conducted at two time points to assess the internal validity and consistency of these five TRG systems.</p><p><strong>Methods: </strong>A test-retest study was performed in 34 pathologically confirmed rectal adenocarcinoma specimens. All patients underwent pre-operative CRT followed by total mesorectal resection. Each specimen was examined twice to examine the variability of test-retest measurements. Every specimen was examined according to the 5 different TRG systems (Dworak, Mandard, Ryan, AJCC, modified Ryan). The time interval between the initial assessment and the repeat assessment was 3 weeks by the same pathologist who was not allowed to know the results of his initial measurements.</p><p><strong>Result: </strong>For TRG systems comparing therapy-induced fibrosis in relation to residual tumor, a very strong correlation among them was found, with correlation coefficient values ranging from 0.964 to 1. The modified Ryan TRG system determines the degree of tumor regression based solely on the quantity of residual viable cancer cells only (not fibrosis). The system had lower correlation coefficient values, ranging from 0.549 to 0.617. The present study revealed an excellent intra-rater correlation coefficient of 0.947 (95% CI: 0.895-0.974) for the Mandard and Dworak TRG systems, 0.918 (95% CI: 835-0.959) for the Ryan TRG system, 0.957 (95% CI: 0.913-0.978) for the AJCC TRG system, and 0.934 (95% CI: 0.867-0.967) for the modified Ryan TRG system.</p><p><strong>Conclusion: </strong>TRG systems with different scales categorizing tumor regression based on residual tumor and fibrosis revealed a strong to very strong correlation among them. The modified Ryan system, which categorizes tumor regression based solely on the quantity of residual viable cancer cells (not fibrosis), resulted in discrepancies in interpretations and lower correlation values. The present study revealed an excellent intra-rater correlation coefficient with high internal validity.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of TP53 and Its Concomitant EGFR Mutation in Lung Cancer Especially Non-Small Cell Lung Cancer.","authors":"Anurag Mehta, Arpita Ghosh Mitra, Samson Mani, Himanshi Dewan, Sakshi Mattoo, Ullas Batra","doi":"10.31557/APJCP.2025.26.1.17","DOIUrl":"10.31557/APJCP.2025.26.1.17","url":null,"abstract":"<p><strong>Background: </strong>Human Lung Carcinoma (LC) is among the most diagnosed cancers across the world among those non-small cell lung cancer (NSCLC) comprises about 85%. Next Generation Sequencing based detection of mutations are now well established in molecular oncology. With the advent of modern diagnostic methods, it is now well known that there are several mutations and gene rearrangements which are associated with the development of LC. Among those mutations, TP53 is the most prevalent with the concomitant EGFR mutation.</p><p><strong>Methods: </strong>In this retrospective study, a total number of 414 patients have been incorporated who have attended RGCIRC in the period between November 2015 to March 2024. Clinical stage has been determined as per NCCN Guideline version 2.2024. Nucleic Acid (DNA and RNA) from FFPE samples were extracted and detection of mutation was performed by Next generation sequencing (NGS) method.</p><p><strong>Results: </strong>All 414 patients opted for the customised NGS panel for lung cancer among those 203 patients were TP53 mutation and 87 patients were EGFR mutation positive. 62 patients were TP53-EGFR double mutation positive. The results of this study have shown that TP53 mutated patients show poor prognosis with conventional therapy. However, TP53-EGFR co-mutated patient's recovery rates are comparatively promising due to the availability of the targeted therapy of EGFR.</p><p><strong>Conclusion: </strong>Studies have shown that TP53 mutation is unlikely to derive clinical benefit in LC patients and shows poorer prognosis when compared to TP53 wild type and EGFR mutated patients show improved recovery due to availability of the Kinase Inhibitor (KI) treatment. In this study we have observed and concluded that TP53-EGFR co-mutated group also shows promising prognosis for the application of KI treatment. A further large cohort study will establish this clinical observation and enlighten more therapeutically relevant information.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in Methodology and Data Reporting: Reflections on a Cholangiocarcinoma Study.","authors":"Sabyasachi Shukla, Sonam Jalewa Agarwal, Puravi Dubey, Pratap Kumar Jena","doi":"10.31557/APJCP.2025.26.1.1","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.1.1","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Genetic Variations in RNA-binding Protein Gene and Breast Cancer Risk: A Case-Control Study.","authors":"Hosna Sarani, Mohsen Taheri, Danial Jahantigh, Mohammad Reza Keramati, Seyed Mehdi Hashemi, Gholamreza Bahari, Saba Taheri","doi":"10.31557/APJCP.2025.26.1.137","DOIUrl":"10.31557/APJCP.2025.26.1.137","url":null,"abstract":"<p><strong>Background: </strong>LIN28, a highly conserved RNA-binding protein, regulate a wide variety of post-transcriptional cellular processes. The current study aimed to identify genetic variants of five single nucleotide polymorphisms (SNPs) in the LIN28B gene (rs221634, rs22163, rs314276, rs9404590, and rs12194974) and their association with Breast cancer.</p><p><strong>Method: </strong>220 patients and 230 controls were genotyped by the RFLP assay for Lin28B gene variants. Odds ratio analysis was used to determine the association between Lin28B variants and breast cancer. Haplotype analysis was performed to determine the combined impact of the investigated variants on BC. Novel in-silico analysis were performed to predict the potential functions of these polymorphisms, as well.</p><p><strong>Results: </strong>Patients carrying all variant genotypes for lin28B rs221634 (codominant, dominant, recessive, and allelic inheritance models), rs221635 (codominant and dominant genotypes), and rs9404590 (codominant, dominant, and inheritance model).  Significant associations between reduced cancer risk and rs12194974 and rs314276 were found in codominant, dominant, recessive, and allele inheritance models. According to haplotype analysis of rs9404590, rs12194974, rs314276, rs221634, and rs221635 SNPs ,the GGCTT, GGCAT, TGCAC, TGCTC, GGCAC, GGCTC, and GGAAC haplotypes are associated with an increased risk of BC, whereas the TACAT and TAAAT haplotypes were associated with a decreased risk of BC. The splicing enhancers (ESE) binding site was found to be altered by the SNPs rs9404590, rs12194974, and rs314276, according to in-silico analysis.</p><p><strong>Conclusion: </strong>Breast cancer susceptibility appears to be linked to genetic variations in the Lin28B gene, and haplotypes in this region have been linked to increased risk.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"137-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Deficiency of Vitamin D and Anthracycline-Taxane Regimen are associated with Cachexia Following Breast Cancer Chemotherapy: A Single Center Assessment Using Two Consensus-Based Criteria.","authors":"Susanna Hilda Hutajulu, Sofi Aresy, Yufi Kartika Astari, Juan Adrian Wiranata, Herindita Puspitaningtyas, Dian Caturini Sulistyoningrum, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, Ibnu Purwanto, Mardiah Suci Hardianti","doi":"10.31557/APJCP.2025.26.1.189","DOIUrl":"10.31557/APJCP.2025.26.1.189","url":null,"abstract":"<p><strong>Background: </strong>Cancer cachexia in breast cancer (BC) patients is not commonly reported, particularly in Indonesia. This study assessed the prevalence of cachexia in local patients with BC receiving chemotherapy, and the associated factors.</p><p><strong>Methods: </strong>This cross-sectional study included 160 BC patients who started chemotherapy between July 2018 and June 2022. We collected data including age, body mass index, comorbidity, stage, surgery type, chemotherapy information, neutrophil-to-lymphocyte ratio, albumin, vitamin D, C-reactive protein, and the presence of chemotherapy-induced nausea and vomiting. We used the Fearon and Evans criteria to define the outcomes of cachexia. A multivariate logistic regression test was used to determine the factors related to the cachexia status following chemotherapy.</p><p><strong>Results: </strong>During and after chemotherapy, 61 participants (38.1%) and 32 participants (20%) experienced cachexia based on Fearon and Evans criteria, respectively. All the patients had a deficient vitamin D concentration at baseline and vitamin D below median value (8.94 ng/mL) was classified as severe deficiency. Vitamin D severe deficiency was associated with an increased risk of cachexia (OR 2.47, 95%CI 1.19-5.11, p=0.014 for Fearon; and OR 2.47, 95%CI 1.03-5.92, p=0.043 for Evans), as well as anthracycline-taxane regimen based on Fearon criteria only (OR 4.35, 95%CI 1.39-13.53, p=0.011).</p><p><strong>Conclusion: </strong>Our findings demonstrated that vitamin D severe deficiency and anthracycline-taxane regimen were associated with cachexia occurrence among BC patients following chemotherapy. Strategies and further investigation are warranted to reduce cachexia occurrence, along with nutritional support during chemotherapy.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"189-197"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability and Determinants of Opportunistic Screening for Breast Cancer in Indian Women.","authors":"Maheshkumar Bhausaheb Jagatap, Ajeet Pratap Maurya, Bharati Pandya, Swagata Brahmachari, Raghvendra Pratap Singh","doi":"10.31557/APJCP.2025.26.1.43","DOIUrl":"10.31557/APJCP.2025.26.1.43","url":null,"abstract":"<p><strong>Background: </strong>Screening for breast cancer has been effective in decreasing mortality. Mammography is not readily available in resource-limited countries like India. Annual clinical breast examination has been demonstrated to be as effective as biennial mammography in reducing mortality with much less cost. In absence of an organized systematic screening program opportunity of women visiting the hospital can be used to educate and screen. The current study was designed to assess the acceptability, determinants of acceptability and effectiveness of opportunistic breast cancer screening.</p><p><strong>Methods: </strong>A prospective cross-sectional study was conducted at a tertiary care center in central India. Women of age >35 years with no breast complaints were offered to undergo screening for breast cancer by clinical breast examination. Women with non-breast related complaints or accompanying some other patients were included. Abnormal findings on clinical breast examination were followed by ultrasound (<40 years of age) or mammography (>40 years of age). Standard methods of examination were used. The sample size was 382 and the duration of the study was 2 years.</p><p><strong>Results: </strong>In the study out of 382 participants 255 (66.74%) accepted the examination and 127 denied. Only 66% of participants consented for screening and a lump was detected in seven (2.7%) women. All seven women with breast lump refused further diagnostic work-up. Acceptance of screening was not significantly affected by religion, educational status, marital status and occupation.</p><p><strong>Conclusion: </strong>There was low acceptability to screening, awareness about breast cancer and treatment compliance rates to further management. Acceptability of screening is not affected by socioeconomic or educational status.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}