Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Relative Survival Rates of Pediatric Patients with Solid Tumours in Khon Kaen, Thailand.","authors":"Surachai Phimha, Prapassara Sirikarn, Chanaporn Pinsuwan, Chalongpon Santong, Su-On Chainansamit, Patcharee Komvilaisak, Kunanya Suwannaying","doi":"10.31557/APJCP.2026.27.9.3341","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3341","url":null,"abstract":"<p><strong>Background: </strong>Pediatric solid tumours constitute a subgroup of childhood cancers that continue to pose a significant global health challenge due to limitations in diagnostic techniques and treatment options. This study aimed to explore the relative survival rates of patients with childhood cancer over two decades using population-based data from a cancer registry.</p><p><strong>Methods: </strong>This population-based study included pediatric patients with cancer in Khon Kaen, Thailand, and focused on children under 15 years of age who were diagnosed with solid tumours from January 1st, 2000, through December 31st, 2019. A total of 371 childhood solid tumours were diagnosed in Khon Kaen during the study period, with follow-up through 2021. Survival analysis was conducted via relative survival rate (RSR) estimates.</p><p><strong>Results: </strong>The most common solid tumours were CNS and miscellaneous intracranial and intraspinal neoplasms (27.7%). The overall 5-year RSR for pediatric patients with solid tumours was 0.57 (95% CI: 0.52-0.62). Compared with male patients, female patients had higher 5-year RSRs (0.62, 95% CI: 0.53-0.68 versus 0.53, 95% CI: 0.46-0.60). Survival improved over time, with patients diagnosed between 2010 and 2019 having better 5-year RSRs than those diagnosed from 2000 to 2009 did (0.59, 95% CI: 0.52-0.66 and 0.55, 95% CI: 0.47-0.62, respectively).</p><p><strong>Conclusions: </strong>In conclusion, better outcomes were observed among females, patients living closer to health care facilities and those diagnosed in the more recent decade (2010-2019).</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3341-3348"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic Resistome of Multidrug-Resistant Klebsiella pneumoniae Bloodstream Infections in Iraqi Cancer Patients.","authors":"Watheq Mohammed Al-Jewari, Bassam Abdul Rasool Hassan, Ali Haider Mohammed, Abu Bakar Abdul Majeed, Muhamad Faiz Othman, Ahmed Zuhair Abdulhameed Alsammarraie, Mohammed Kamil Al Qayyim, Musaab Kadhim Alabboodi","doi":"10.31557/APJCP.2026.27.9.3333","DOIUrl":"10.31557/APJCP.2026.27.9.3333","url":null,"abstract":"<p><strong>Background: </strong>Multidrug-resistant (MDR) Klebsiella pneumoniae is an important cause of bloodstream infection (BSI) in cancer patients, particularly those with haematological malignancies, where delayed or inappropriate therapy is associated with high mortality. Genomic data on resistance mechanisms in oncology settings in Iraq remain limited. This study aimed to characterise, using whole-genome sequencing, the antibiotic resistance determinants of MDR K. pneumoniae bloodstream isolates from cancer patients and to explore their potential implications for empirical treatment strategies in this high-risk population.</p><p><strong>Methods: </strong>This genomic substudy was nested within a prospective multi-centre cohort of cancer patients with bloodstream infection at oncology hospitals in Baghdad. Adult patients with haematological malignancies and solid tumours with monomicrobial MDR K. pneumoniae infection were included. Identification and antimicrobial susceptibility testing were performed using the VITEK 2 system and interpreted according to Clinical and Laboratory Standards Institute standards. MDR was defined as non-susceptibility to at least three antibiotic classes. Whole-genome sequencing was performed using an Illumina platform. Resistance genes were identified using curated databases and grouped into β-lactamase/carbapenemase, non-β-lactam, and efflux/regulatory categories. Clinical data (age, sex, and malignancy type) were extracted from medical records.</p><p><strong>Results: </strong>Thirty-five MDR K. pneumoniae bloodstream isolates were analysed, with most infections occurring in patients with haematological malignancies (30/35, 85.7%). Detected resistance genes included CTX-M-type extended-spectrum β-lactamases (including CTX-M-15), SHV and TEM enzymes, and OXA-48-like carbapenemases (OXA-48 and OXA-232). Non-β-lactam resistance determinants (aadA, EreA, Mph(A), Mrx, sul1, sulI) and efflux-related genes were also identified.</p><p><strong>Conclusions: </strong>MDR K. pneumoniae bloodstream infections in this cohort were predominantly observed in patients with haematological malignancies. Whole-genome sequencing identified multiple resistance determinants. These findings provide genomic insights that may help explain resistance patterns in this setting and support the need for strengthened infection prevention and locally tailored antimicrobial stewardship strategies.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3333-3340"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of miR-214 in Pediatric Acute Leukemia: Correlations with Leukemia Subtypes, Familial Predisposition, and Hepatitis B Virus Infection.","authors":"Maysaa N Ibrahim, Ruqaia Sabbar Salman, Anfal M Khudhair, Dunya Jawad Ridha, Rasha Tariq Jawad, Muhammed Munim Radwan, Aya Ali Mohammed, Jaafar Alsadiq Arkan Farhan Ali, Hayder Rafid Abduljalil","doi":"10.31557/APJCP.2026.27.9.3325","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3325","url":null,"abstract":"<p><strong>Background: </strong>miR-214 dysregulation has been implicated in various cancers, yet its role in pediatric acute lymphoblastic leukemia (ALL) is not fully understood. This study evaluated miR-214 expression in newly diagnosed pediatric ALL patients and explored associations with leukemia subtypes, family history, and hepatitis B virus (HBV) infection.</p><p><strong>Methods: </strong> Bone marrow aspirates were collected from 44 pediatric ALL patients (26 B-ALL, 18 T-ALL) and five non-leukemic controls. qRT-PCR quantified miR-214 expression. Clinical data included HBV status and family history of hematologic malignancy. Relative expression levels were analyzed using 2-ΔΔCt and log₁₀ transformed for statistical analyses, including correlation and logistic regression models with interaction terms.</p><p><strong>Aim of the study: </strong>The present study aimed to quantitatively evaluate the expression pattern of miR-214 in newly diagnosed pediatric acute lymphoblastic leukemia (ALL) patients compared with non-leukemic controls. In addition, the study sought to investigate whether miR-214 expression differs according to immunophenotypic subtype (B-ALL versus T-ALL) and to explore its potential associations with clinical and host-related factors, specifically family history of hematologic malignancy and hepatitis B virus (HBV) infection status. Furthermore, this study aimed to assess whether these variables exert interaction effects that may reflect context-dependent regulation of miR-214 in pediatric leukemogenesis.</p><p><strong>Results: </strong> miR-214 expression was generally downregulated in ALL compared to controls, though differences were not statistically significant. B-ALL patients showed lower median expression than T-ALL, with the lowest levels observed in those with a positive family history. T-ALL patients exhibited broader expression variability, including marked upregulation in some cases. Exploratory regression models suggested differential effects of miR-214 based on HBV status and family history, but interaction terms did not reach statistical significance (p > 0.05).</p><p><strong>Conclusions: </strong>miR-214 expression in pediatric ALL appears to vary according to leukemia subtype and selected clinical factors, including family history and HBV infection. However, no statistically significant interaction effects were observed. These findings should be considered preliminary and warrant validation in larger, adequately powered cohorts to clarify the potential clinical relevance of miR-214 in leukemogenesis.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3325-3332"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Network Pharmacology and Experimental Validation of Sesbania grandiflora as a Multi-Targeted Therapeutic Agent Against Oral Squamous Cell Carcinoma (OSCC).","authors":"Reyana Begam R, Gheena Sukumaran, Abilasha Ramasubramaniam","doi":"10.31557/APJCP.2026.27.9.3193","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3193","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) remains a significant health burden with limited therapeutic options and high mortality. Sesbania grandiflora, a medicinal plant rich in phytochemicals, has been traditionally used for its medicinal properties and is emerging as a potential anticancer agent.</p><p><strong>Objective: </strong>This study aimed to investigate the anticancer mechanisms of S. grandiflora against OSCC using an integrated approach, combining network pharmacology, molecular docking, ADME profiling, and in vitro validation.</p><p><strong>Materials and methods: </strong>Network pharmacology was employed to identify hub genes and pathways associated with S. grandiflora bioactives. Molecular docking was performed to evaluate binding interactions of D-glucuronic acid, a major phytoconstituent, with key cancer-related targets. ADME profiling assessed drug-likeness and pharmacokinetic properties. in vitro assays, including MTT, flow cytometry, and Western blotting, were conducted on KB oral cancer cells to validate mechanistic insights.</p><p><strong>Results: </strong>Key hub genes identified included AKT1, BCL2, PIK3CA, MTOR, and CASP8, which were enriched in pathways such as the PI3K-Akt, p53, HIF-1, and EGFR-mediated apoptosis pathways. Molecular docking revealed strong and stable interactions of D-glucuronic acid with target proteins, supporting its multi-targeted activity. ADME analysis indicated favorable pharmacokinetic properties, including high GI absorption, BBB permeability, and minimal CYP450 inhibition. Experimental validation demonstrated significant cytotoxicity (IC₅₀: 250-300 µg/mL), dose-dependent G1-phase cell cycle arrest, downregulation of BCL-2, and upregulation of BAX, confirming the induction of apoptosis.</p><p><strong>Conclusion: </strong>S. grandiflora exerts anticancer effects through modulation of PI3K-AKT-mTOR and apoptotic pathways. D-glucuronic acid emerges as a promising bioactive compound, supporting further in vivo studies and clinical exploration for OSCC management.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3193-3201"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open, Laparoscopic, Retropubic, or Robotic? A Network Meta-Analysis of Post-Prostatectomy Oncologic Outcomes and Health-Related Quality of Life in Localized Prostate Cancer Patients.","authors":"Revina Maharani, Manarul Iman Alfafa Rachman, Putra Mahakarya Dewa, Michelle Gunawan, Kartika Taufani Sukarno, Besut Daryanto","doi":"10.31557/APJCP.2026.27.9.3355","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3355","url":null,"abstract":"<p><strong>Objective: </strong>Prostatectomy remains a standard surgical treatment for localized prostate cancer, a malignancy with substantial global incidence and clinical impact in men. Its rapid adoption of surgical modalities has outpaced supporting evidence, resulting in limited consensus in reporting HRQoL and oncologic outcomes. This paper aims to compare the oncologic and Health-Related Quality of Life (HRQoL) outcomes of open (ORP), retropubic (RRP), laparoscopic (LRP), and robot-assisted radical prostatectomy (RARP) in patients with localized prostate cancer.</p><p><strong>Methods: </strong>A systematic search of MEDLINE/PubMed, Embase, Cochrane Library, and grey literature for randomised controlled trials and comparative studies was performed from database inception to November 2025. Risk of bias was assessed using RoB 2.0 and ROBINS-I. A network meta-analysis evaluated oncological outcomes that consist of Biochemical Recurrence (BCR) and Positive Surgical Margins (PSM), and HRQoL metrics including urinary incontinence and erectile dysfunction. Ranking probabilities were estimated using Surface Under the Cumulative Ranking (SUCRA) values.</p><p><strong>Result: </strong>Thirty-three studies that met the inclusion criteria were included involving 69986 patients. Overall risk of bias for both randomized and observational studies was low. RARP ranked highest for oncologic outcomes, demonstrating the greatest likelihood of minimizing BCR (SUCRA 84.2%; 14 trials, 17,932 patients) and PSM (SUCRA 93%; 29 trials, 38,509 patients). For HRQoL, non-robotic techniques were favored across specific domains: ORP showed a 76% probability of fewer urinary incontinence events; LRP demonstrated an 87% likelihood of requiring fewer pad changes; and RRP demonstrated a 95% probability of being the best-tolerated technique regarding postoperative erectile dysfunction.</p><p><strong>Conclusion: </strong>RARP appears as the most favourable oncological outcome, whereas non-robotic approaches showed advantages in HRQoL domains. Future randomized trials are needed to prove the superiority of the techniques.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3355-3363"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer and Bactericidal Activity of Manganese Ferrite Nanoparticles Synthesised by Using Allicin Extract.","authors":"Sakthivel Muthu, Priyadharsani Vajjiravelu, Tanish Madhav Giridharan, Vanaja Mahendran, Bharathi Venkatachalam, Mythileeswari Lakshmikanthan, Shenbhagaraman Ramalingam","doi":"10.31557/APJCP.2026.27.9.3253","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3253","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to synthesize manganese ferrite (MnFe₂O₄) nanoparticles (MnF NPs) using allicin extracted from Allium sativum and to assess their bactericidal and anticancer activities.</p><p><strong>Methods: </strong>Allicin from A. sativum was extracted using ethanol and confirmed by UV-visible spectrophotometer (λ max 240 nm). AMnF nanoparticles (Allicin-MnF NPs) synthesized via a co-precipitation route using allicin extract as reducing and stabilizing agent. The synthesized AMnF NPs were characterized using various instrumental techniques such as UV-vis absorption spectroscopy, FTIR, and SEM. Bactericidal activity was assessed by Agar well diffusion and MBC/MIC determination methods. Anticancer activity was examined against IMR-32 neuroblastoma cells and normal Vero cells using the MTT assay.</p><p><strong>Results: </strong>The synthesized AMnF NPs showed a distinct band in UV-vis absorption at 290 nm and FTIR bands characteristic of spinel ferrite metal-oxygen vibrations (555 cm⁻¹), along with organic functional groups from allicin. SEM analysis revealed agglomerated, near-spherical particles of 20-50 nm. The allicin extract exhibited notable bactericidal activity against Enterobacter sp and Staphylococcus aureus (MBC/MIC≤1.5), while showing bacteriostatic effects against Clostridium sp., Escherichia. coli, and Salmonella sp. The bactericidal behavior of the AMnF NPs depended on their concentration, with the highest action demonstrated against S. aureus and B. subtilis strains (100 µg/mL). Cytotoxic effects of NPs were dependent on concentration with an inhibitory concentration at 54.6 µg/mL, similar to doxorubicin at IC₅₀ 46.33 µg/mL. Toxic effects on normal cells, such as Vero, were noted to be minimal at IC₅₀ of >90 µg/mL.</p><p><strong>Conclusion: </strong>The nanoparticles synthesized with the help of allicin display efficient antibacterial and antitumor effects while being non-toxic to healthy cells.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3253-3263"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study of Knowledge, Attitudes, and Perceptions toward HPV Vaccination Among Undergraduate Students Studying in Sarawak, Malaysia.","authors":"Melissa Siaw Han Lim, Shirley Siang Ning Tan, Mohamad Adam Bujang, Jordan Ferguson Anak Shandra, Nurain Nazwa Binti Nor Azman, Siti Naura Insyirah Binti Mohd Razali, Mee Fong Tan, Izzati Binti Wan Maharuddin, Adam Malik Bin Ismail, Rahmah Binti Rashid, Xun Ting Tiong, Pei Jye Voon","doi":"10.31557/APJCP.2026.27.9.3365","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3365","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer remains a significant public health problem, particularly in low- and middle-income countries, and is mainly caused by persistent infection with high-risk human papillomavirus (HPV). Despite Malaysia's national HPV vaccination program, gaps in knowledge, misconceptions, and suboptimal vaccine uptake persist even among university students.</p><p><strong>Objective: </strong>This study aimed to assess HPV-related knowledge, attitudes and perceptions toward HPV vaccination among undergraduate students studying in Sarawak, and to identify sociodemographic factors associated with knowledge levels.</p><p><strong>Results: </strong>A total of 382 undergraduate students participated, of whom 55% were unvaccinated against HPV. Overall, HPV knowledge was moderate, with students from health faculties demonstrating higher HPV knowledge compared with those from non-health faculties ([aOR] = 2.0, 95% CI: 1.1-3.5; p = 0.016); Indian participants had significantly higher odds of high HPV-related knowledge compared with Malay participants (adjOR = 2.7, 95% CI: 1.0-7.0; p = 0.043). Vaccinated students have significantly higher HPV-related knowledge compared with unvaccinated students (adjOR = 1.9, 95% CI: 1.2-3.0; p=0.007). Attitudes toward HPV vaccination were generally positive, although concerns regarding cost, safety, and social stigma remained.</p><p><strong>Conclusion: </strong>Undergraduate students demonstrated moderate knowledge and positive attitudes toward HPV vaccination; however, notable knowledge gaps and misconceptions persist, particularly among non-health students and those who were unvaccinated. Targeted educational strategies and improved access to reliable information are essential to strengthen HPV prevention efforts.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3365-3375"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma miR-141-3p as a Potential Diagnostic Biomarker for Early Breast Cancer and a Functional Regulator with Tumor-Suppressive Effects in Luminal A Breast Cancer Cells.","authors":"Thuy Thi Chung Duong, Thanh Thi Ngoc Nguyen, Luan Huu Huynh, Nga Thi Nguyen, Hue Thi Nguyen","doi":"10.31557/APJCP.2026.27.9.3227","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3227","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer (BC) remains the most common malignancy in women worldwide, highlighting the need for reliable non-invasive biomarkers for early detection. miR-141-3p, a member of the miR-200 family, has shown context-dependent roles in tumorigenesis, but its diagnostic specificity and clinical relevance in the plasma of patients with BC remain incompletely understood. Therefore, this study aimed to assess the diagnostic potential and functional role of miR-141-3p in BC.</p><p><strong>Methods: </strong>Plasma miR-141-3p levels were quantified in breast cancer patients and healthy controls using RT-qPCR. Diagnostic capacity was evaluated via receiver‑operating characteristic (ROC) analysis. Associations between circulating miR-141-3p expression and BC risk were assessed using odds ratios (ORs). In vitro functional assays in MCF‑7 cells (miR‑141‑3p overexpression) examined effects on proliferation, migration, and regulation of target genes.</p><p><strong>Results: </strong>Circulating miR-141-3p was significantly upregulated in BC patients. ROC analysis yielded an AUC of 0.877 (95% CI: 0.782-0.971), demonstrating good diagnostic performance. No statistically significant stage-dependent difference was observed, suggesting that circulating miR-141-3p dysregulation may not simply reflect tumour burden. In vitro, miR‑141‑3p overexpression suppressed MCF‑7 cell proliferation and migration and reduced expression of EMT‑associated markers. Furthermore, strong inverse correlations were observed between miR‑141‑3p levels and its predicted oncogenic targets.</p><p><strong>Conclusion: </strong>Circulating miR‑141‑3p shows promise as a non‑invasive biomarker for BC detection and risk discrimination, although its specificity as a stand-alone marker may be limited. Its in vitro effects on proliferation, migration, and EMT markers indicate potential functional relevance. Further validation in larger cohorts and through in vivo studies is warranted.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3227-3235"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Study of Micheliolide Derivatives as Potential Non-Small Cell Lung Cancer Drugs Targeting the Epidermal Growth Factor Receptor.","authors":"Sahat Halim, Aziza Harris, Steffi Cong Andi Nata, Achmad Mudassir Muchlis, - Darmadi, Herikurniawan Herikurniawan, Cleopas Martin Rumende","doi":"10.31557/APJCP.2026.27.9.3265","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3265","url":null,"abstract":"<p><strong>Objective: </strong>To identify Micheliolide-based derivatives with favorable drug-like properties and inhibitory potential against the epidermal growth factor receptor (EGFR) using an integrated in silico approach.</p><p><strong>Methods: </strong>Micheliolide derivatives were evaluated for pharmacokinetic and toxicity profiles using SwissADME and ADMET-AI, and anticancer-related activity was predicted using PASS Online. Molecular docking was performed with AutoDock Vina using erlotinib as a reference ligand. The top-ranked compounds were further examined through 50 ns molecular dynamics simulations to assess complex stability.</p><p><strong>Results: </strong>All derivatives fulfilled Lipinski's criteria. Several compounds demonstrated favorable predicted bioavailability and anticancer probability. Docking analysis identified compound 10 as having the strongest binding affinity, followed by compounds 19 and 3, with all three occupying the same EGFR binding pocket as erlotinib. Molecular dynamics simulations showed that compounds 3 and 19 formed more stable complexes, maintaining root-mean-square deviation values of approximately 1-3 Å throughout the trajectory, whereas compound 10 displayed greater fluctuations and reduced stability.</p><p><strong>Conclusion: </strong>Compounds 3 and 19 exhibited the most favorable combination of binding affinity, dynamic stability, and predicted safety profiles, highlighting their potential as lead candidates for further development as EGFR inhibitors in NSCLC.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3265-3272"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Cannabinoid Receptor 1 Expression in Thai Patients with Cholangiocarcinoma and Its Prognostic Implications.","authors":"Teerapat Ungtrakul, Chitiarpa Amatawet, Thaniya Sricharunrat","doi":"10.31557/APJCP.2026.27.9.3349","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3349","url":null,"abstract":"<p><strong>Objective: </strong>Cholangiocarcinoma (CCA) is highly prevalent in Thailand and remains associated with poor outcomes. Emerging evidence suggests that dysregulation of the endocannabinoid system may be involved in CCA pathogenesis and prognosis. This study aimed to evaluate the prevalence of cannabinoid receptor 1 (CB1) expression and its association with clinicopathological features and survival outcomes in Thai patients with CCA.</p><p><strong>Methods: </strong>We retrospectively reviewed patients with histologically confirmed CCA treated at a tertiary cancer center in Thailand between January 2014 and December 2018. CB1 expression in tumor tissues was assessed by immunohistochemistry and semi-quantitatively scored according to staining intensity and extent.</p><p><strong>Results: </strong>Tumor specimens from 51 patients (median age 59 years; 41% female) were analyzed. Most patients had intrahepatic CCA (80%), and 47% presented with advanced-stage disease (stages III-IV). High CB1 expression was observed in 46 of 51 cases (90%). Patients with high CB1 expression more frequently had advanced-stage disease. During a median follow-up of 27.8 months, 34 patients died. The median overall survival (OS) was 18.5 months (95% CI, 6.1-36.5). There was no statistically significant difference in OS between patients with high and low CB1 expression (median OS 18.5 vs. 23.0 months, respectively; p = 0.68).</p><p><strong>Conclusion: </strong>High CB1 expression is highly prevalent in Thai patients with CCA. While no significant associations with clinicopathological features or survival were found in this small cohort, the widespread overexpression of CB1 supports its potential biological and therapeutic relevance in CCA and warrants further investigation in larger studies.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3349-3354"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}