印尼Persahabatan医院国家呼吸中心非小细胞肺癌组织样本中巨细胞病毒DNA比例高。

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-06-01 DOI:10.31557/APJCP.2025.26.6.1987

Ibrahim Nur Insan Putra Dharmawan, Jamal Zaini, Irandi Putra Pratomo, Eylin Rahardjo, Hana Khairina Putri Faisal, Dicky Soehardiman, Erlang Samoedro, Triya Damayanti, Diah Handayani, Fanny Fachrucha, Dimas Ramadhian Noor, Sita Laksmi Andarini

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引用次数: 0

摘要

背景：巨细胞病毒（CMV）是一种在普通人群中具有高血清阳性率的病毒。最近的证据表明，巨细胞病毒与包括肺癌在内的多种癌症有关。本研究旨在确定巨细胞病毒与非小细胞肺癌（NSCLC）之间的关系。本研究的数据将有助于进一步研究CMV与肺癌之间的联系。方法：本研究是一项观察性研究，采用横断面法测定CMV DNA在NSCLC组织样本中的比例。2017-2023年在Persahabatan医院的档案中采集了福尔马林固定石蜡包埋（FFPE）组织样本。采用聚合酶链反应（PCR）和电泳检测CMV。相关数据取自医疗记录。结果：本研究共纳入87名不同受试者的87份组织样本。大多数研究对象是男性吸烟者，布林克曼指数严重，平均年龄为59.1岁。FFPE标本中检测到CMV DNA的比例为21%。在EGFR阳性突变的组织样本中，CMV DNA的比例更高，但没有统计学意义。CMV DNA比例与吸烟状况、Brinkman指数、组织取样方法、NSCLC亚型无关。结论：印度尼西亚非小细胞肺癌FFPE标本中巨细胞病毒DNA检测比例较高。在EGFR突变的NSCLC中，CMV DNA的比例更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

High Proportion of Cytomegalovirus DNA from Tissue Samples of Non Small Cell Lung Carcinoma in Persahabatan Hospital National Respiratory Center, Indonesia.

Background: Cytomegalovirus (CMV) is a virus with high seroprevalence in general population. Recent evidence shows that CMV is linked to various types of cancer, including lung cancer. This study aims to determine the relationship between CMV and non-small cell lung carcinoma (NSCLC). Data from this study will be useful for further research in elucidating the link between CMV and lung cancer.

Method: This research was an observational study using a cross-sectional method to determine the proportion of CMV DNA in NSCLC tissue samples. Formalin-fixed paraffin-embedded (FFPE) tissue samples were taken from archival at Persahabatan Hospital on 2017-2023. The detection of CMV was carried out using polymerase chain reaction (PCR) and electrophoresis. Accompanying data was taken from medical records.

Results: A total of 87 tissue samples from 87 different subjects were included in this study. Most of the research subjects were male smokers, had a heavy Brinkman index with an average age of 59.1 years. The proportion of CMV DNA detected in FFPE samples was 21%. The proportion of CMV DNA was higher in tissue samples with positive EGFR mutations although not statistically significant. The proportion of CMV DNA was not related to smoking status, Brinkman index, tissue sampling method, and NSCLC subtype.

Conclusion: High proportion of cytomegalovirus DNA were detected in NSCLC FFPE samples in Indonesia. The proportion of CMV DNA was higher in NSCLC with EGFR mutations.

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.