Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Comparison Between Breath-Hold and the Inspiratory Phase of Free Breathing in Left Breast Cancer Radiotherapy: Target Volume Coverage and Organ Sparing.","authors":"Sarah Hazem Hussein, Loay Kassem, Mohamed Ibrahem Adrosy, Hussein Metwally","doi":"10.31557/APJCP.2025.26.3.969","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.969","url":null,"abstract":"<p><strong>Background: </strong>Cardiac mortality and coronary events associated with left breast radiotherapy are correlated with the mean radiation dose to the heart.</p><p><strong>Methods: </strong>This prospective phase II study included left breast cancer patients receiving adjuvant locoregional radiotherapy with intensity-modulated radiation therapy (IMRT) following surgery. Patients were treated using the respiratory gating (RPM) technique (Varian Medical Systems, USA). Dosimetric outcomes were compared between deep inspiration breath-hold (DIBH) and the inspiratory phase of free breathing (FB) in the same patients, focusing on target volume coverage and sparing of critical organs (lungs, heart, and coronary arteries). The prescribed dose was 50 Gy in 25 fractions over five weeks to the chest wall or breast and/or lymph nodes, with an additional boost of 10 Gy in five fractions over one week to the tumor bed in breast-conserving surgery (BCS) cases. Two treatment plans were generated per patient: one for DIBH and another for the inspiratory phase of FB.</p><p><strong>Results: </strong>Between February 2020 and August 2022, 60 patients with a mean age of 50 years were enrolled in the study. The dosimetric analysis showed that the mean heart dose was lower in the DIBH group (4.8 Gy) compared to the FB group (6.4 Gy) with a statistically significant difference (p < 0.0001). Similarly, the mean dose to the left anterior descending artery (LAD) was significantly reduced in DIBH (14 Gy) compared to FB (20.5 Gy) (p < 0.0001). Regarding target volume coverage, the mean planning target volume (PTV) V95% was slightly higher in DIBH (97.3%) than in FB (96.5%) (p = 0.0062). The mean left lung V20 was comparable between the two techniques, with values of 14.4% in DIBH and 14.35% in FB (p = 0.85), indicating no significant difference in lung dose sparing. However, the mean left ventricular dose was significantly lower in DIBH (6 Gy) compared to FB (8.1 Gy) (p < 0.0001), further supporting the advantage of DIBH in reducing cardiac radiation exposure.</p><p><strong>Conclusion: </strong>DIBH plans demonstrated superior target coverage and significantly improved cardiac and coronary sparing compared to FB inspiratory phase plans. However, FB plans remained within acceptable dose constraints. No significant differences were observed in lung dose sparing or beam-on time.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"969-975"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing and Implementing a Cancer Screening Program for Underserved Tribal Women in Jharkhand.","authors":"Rahul Rewati Raman, Somika Meet, Hemlata M Tiwari, Kunal Oswal, Neetu Sinha, Amol Gaikwad, Yogesh Jain, Umesh Rana, Ramachandran Venkataramanan, Rengaswamy Sankaranarayanan","doi":"10.31557/APJCP.2025.26.3.977","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.977","url":null,"abstract":"<p><strong>Background: </strong>The status of cancer screening in India is concerning, especially in tribal states like Jharkhand, where the percentage of women who have ever undergone screening for cervical, breast, and oral cancer is 0.5, 0.1, and 0.2 percent, respectively. Adopting the community-led approach, Karkinos Healthcare, a purpose driven oncology platform, conducted a cancer screening program in collaboration with a livelihood-focused NGO in selected districts of Jharkhand. This study aims to describe the program's implementation and assess the program's performance vis a vis provision of care continuum from screening to treatment.</p><p><strong>Methods: </strong>The program was designed to provide comprehensive services including cancer awareness, enrolment for specialized cancer insurance for one year to cover the cost of treatment, risk assessment, screening for oral, breast, and cervical cancers, diagnostics to screen positive cases, and treatment to the confirmed cancer cases.</p><p><strong>Results: </strong>A total of 16875 women underwent risk assessments, all of whom were invited for screening at community clinics. A total of 5993 women (34.9%) reported at community clinics and 5873 (34.9%), 5843 (34.7%), and 5029 (29.9%) underwent screening for oral, breast, and cervical cancer. 70% of the total HPV-positive cases had high-risk types other than HPV 16 and 18. 22.4% of the total screened women were navigated for advanced diagnostics and treatment among which 6 confirmed cases of cancer were reported.</p><p><strong>Conclusion: </strong>While the program design tried to address the implementation challenges like fragmented care, accessibility, and affordability of cancer care services, conversion from screening to treatment was limited.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"977-984"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise Therapy, Systemic Acupuncture and Silicon Oxide Tablets in the Rehabilitation of Physical and Functional Disorders in Breast Cancer Survivors: Randomized Clinical Trial.","authors":"Patricia Santolia Giron, Cinira Assad Haddad, Samantha Karlla Lopes De Almeida Rizzi, Simone Elias, Afonso Celso Pinto Nazario, Gil Facina","doi":"10.31557/APJCP.2025.26.3.809","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.809","url":null,"abstract":"<p><strong>Objective: </strong>To compare three rehabilitation treatments, exercise therapy, acupuncture, and silicon oxide tablets (Stiper®), in women undergoing breast cancer surgery, assessing pain, depression, upper limb function, and range of motion parameters (ROM).</p><p><strong>Methods: </strong>Seventy-nine women with pain above 3 on the visual analog pain scale (VAS) were divided into three groups: exercise group was treated with exercise therapy, acupuncture group was treated with acupuncture, and Stiper® group was treated with silicon oxide tablets in place of needles.</p><p><strong>Results: </strong>Sixty-seven patients completed the treatment, 26 from exercise group, 23 from acupuncture group, and 18 from Stiper® group . There was an improvement of pain over time in all groups, the first session compared with the fifth (p < 0.001) and with the tenth (p < 0.001), but not between groups. There was a statistically significant difference in depressive symptoms using the Beck questionnaire over time in the three groups, between the first and tenth sessions (p = 0.001), between the first and fifth sessions (p = 0.052), but not between groups. Regarding the DASH questionnaire for shoulder function, there were significant differences over time at all evaluated moments (p<0.001), but not between groups. There was a statistically significant difference in ROM over time in the three groups, but not between groups.</p><p><strong>Conclusion: </strong>The rehabilitation of physical dysfunctions in women who survived breast cancer through exercise therapy, acupuncture, and silicon oxide tablets in pain, depression, upper limb function, and ROM, proved to be effective, without statistical difference between the groups.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"809-817"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PTEN and HES1 Gene Expression Alteration in Breast Cancer: Any Association with Tumor Histomorphological Features or Invasive Behavior?","authors":"Maryam Zahedi, Nooshin Zaresharifi, Sahand Karimzadhagh, Alireza Abdollahi, Zohreh Nozarian","doi":"10.31557/APJCP.2025.26.3.935","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.935","url":null,"abstract":"<p><strong>Background: </strong>Genomic techniques and the evaluation of epigenetic and proteomic alterations are increasingly used to predict breast tumors' behavior and histopathological patterns. While some studies have linked PTEN and HES1 gene expression to tumor aggressiveness and metastatic behavior, others have not confirmed these associations. This study aimed to assess PTEN and HES1 gene expression in breast cancer lesions and explore their relationship with tumor morphological features and behavior.</p><p><strong>Methods: </strong>This cross-sectional study involved 50 women with breast cancer. Tumor and adjacent normal breast tissue (50 each) were collected to assess PTEN and HES1 gene expression using Real-Time PCR. RNA extraction was performed using the Trizol method, followed by cDNA synthesis. Gene expression changes were quantified using the ΔΔCT method. Statistical analysis was conducted using SPSS version 23.0, with significance set at p ≤ 0.05.</p><p><strong>Results: </strong>PTEN down-regulation was observed in 70.0%, and HES1 up-regulation in 98.0% of cases. No significant association was found between PTEN down-regulation and tumor-related characteristics, except for a significantly higher mean age in patients with down-regulated PTEN (p = 0.003). HES1 expression intensity, with a mean fold change of 6.193 (median: 4.560, SD: 5.116), showed no significant relationship with any histopathological features or invasive behavior.</p><p><strong>Conclusion: </strong>Older patients showed reduced PTEN expression. Additionally, elevated HES1 was identified in 98% of patients and lower PTEN in 70%. However, these gene alterations do not seem to reliably predict aggressive tumor behavior in our population, possibly due to the limited sample size. Further studies with long-term follow-up are needed to fully evaluate the prognostic significance of these markers.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"935-941"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Fusion Genes and Their Relation with Genetic Variants in Egyptian AML Patients.","authors":"Reham Abdel Haleem Abo Elwafa, Magdy Mamdouh ElBordiny, Akram Deghedy, Ashraf Elghandour, Engy Taher Ammar","doi":"10.31557/APJCP.2025.26.3.1069","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.1069","url":null,"abstract":"<p><strong>Background: </strong>Acute myeloid leukemia (AML) is a clonal malignant disorder of the bone marrow. Genetic aberrations have an unequivocal role in disease pathogenesis. With the application of next-generation sequencing technologies (NGS), an enormous number of genetic fusions and variants has been detected. Their co-occurrence has an impact on patient`s prognosis. Therefore, our aim in this study was to survey fusion genes as well as their relation with genetic variants.</p><p><strong>Subjects and methods: </strong>Targeted sequencing of the following fusion genes, in bone marrow aspirate samples, was performed; MECOM, MET, MLLT10, MLLT3, MYBL1, MYH11 and NTRK3. In addition sequencing for the hot spot regions in the following genes was done: FLT3, KIT, NRAS, KRAS, HRAS, using OncomineTM myeloid research panel on Ion S5 NGS system. The study was conducted on 24 denovo Egyptian AML patients of both sexes.</p><p><strong>Results: </strong>We identified one fusion in MYH11 gene (CBFB::MYH11) in two cases with four fusion transcripts of rare types. In addition, one novel breakpoint in MYH11 gene was identified. Also, about 337 variants in five genes were detected in all patients. Majority of them were benign. In the two positive cases for fusion; three pathogenic variants (2 KRAS, 1 NRAS), and one not-reported variant in FLT3 were reported.</p><p><strong>Conclusions: </strong>NGS has a major role in detection of genetic variants and fusions, which will have an impact on AML patient's prognosis.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"1069-1078"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure of Spargue Dawley Rats to Phone Cell Electromagnetic Field Frequency and Related Physiological, Apoptotic and Molecular Profile of Para Oral Tissues: In-vivo Study.","authors":"Gehan Abdel Naser Abdel Rahman, Aly Fahmy Mohamed","doi":"10.31557/APJCP.2025.26.3.985","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.985","url":null,"abstract":"<p><strong>Objective: </strong>Daily exposure to cellular EMF induced a long run deleterious impact. Accordingly, the aim of the present work is to find out the deleterious drawbacks of daily exposure of human to the cellular EMF concerning the pathological, biochemical /physiological and apoptosis profile in EM and EMF/Avocado, sole Avocado and EMF exposed /recovery group of rats.</p><p><strong>Methods: </strong>Different age (Adult, young and Senile) groups were considered. Exposure of S, A and Y rats to EMF showed elevated ROS, MDA and reduced SOD and administration of avocado customized the changes of oxidative stress. Apoptotic activity of both tongue and PG of Y, A and senile rats exposed to EMF showed age dependent response. The apoptotic effect was arranged positively as S, Y and A, revealing higher necrotic activity, Early and late apoptosis in S, Y and A rats. PG tissue showed a noticeable resistance to EMF effect.</p><p><strong>Conclusion: </strong>Also, the physiological alteration was detected insignificantly among test groups where EMF/Avocado treated groups showed almost normalization of oxidative stress compared with its values in control and EMF/Avocado and EMF recovery groups. Also, pathological changes detected in exposed groups showed the same recurrency of different tissue to normal profile.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"985-994"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Cytotoxicity, Impact on Cell Migration and Apoptotic Modulation of Acteoside and Plantamajoside on Human Breast Adenocarcinoma (MCF-7).","authors":"Kyle Andrei Cabatit, Lara Justine Carandang, Dianne Joyce Saragpon, Khayria Minalang, John Paulin, Mark Kevin Devanadera, Minerva Daya","doi":"10.31557/APJCP.2025.26.3.925","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.925","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the anticancer potential of Acteoside and Plantamajoside using MCF-7 cancer cell line.</p><p><strong>Methods: </strong>In this study, the half-maximal inhibitory concentration (IC50) values of Acteoside and Plantamajoside were investigated using the Sulforhodamine B (SRB) assay. The IC50 values of both compounds were utilized in the clonogenic and scratch wound assays to assess cell survival and migration, respectively. The cells with treatments were also analyzed using the Caspase 3/7 assay to determine their capability to induce cell apoptosis. Network Pharmacology was used to evaluate their probable protein targets and pharmacological mechanisms.</p><p><strong>Results: </strong>Acteoside and Plantamajoside exhibited cytotoxic activity against the MCF-7 cancer cell line in vitro, with IC50 values of 134.83 μg/mL and 225.10 μg/mL, respectively. This was further supported by clonogenic assay, which showed a difference in colony formation following treatment with ACT and PMS, compared to the negative control. Specifically, ACT resulted in the formation of only 39.7% of colonies, whereas PMS formed 51.12% of colonies, indicating that these compounds impaired the cells' ability to proliferate and form colonies.  Moreover, these compounds were also able to inhibit cell migration as a reduction in the migration area of the MCF-7 cell line was observed. An increase in the percentage of apoptotic cells was also noted post-treatment, which correlated with elevated Caspase 3/7 activity, indicating that these compounds may effectively induce cellular apoptosis. In silico predictions demonstrated that the compounds' anticancer effect may be attributed to their interactions with TLR, PI3K, and STAT-all are implicated in the PD-1 checkpoint pathway and PD-L1 expression in cancer.</p><p><strong>Conclusion: </strong>Both Acteoside and Plantamajoside have demonstrated promising anticancer properties by inhibiting the growth and metastasis of MCF-7 cancer cell line. These compounds induce apoptosis, modulate the PD-1 checkpoint pathway, and influence PD-L1 expression, which may indicate possible molecular mechanisms for their anticancer effects.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"925-934"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Esophageal Cancer Care: The Power of Early Detection and AI.","authors":"Raja Muhammad Umer Panhwar, Qurat Ul Ain Iftikhar","doi":"10.31557/APJCP.2025.26.3.713","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.713","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"713-714"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Biomarkers in Thyroid Malignancies: Evaluating Thyroid-Stimulating Hormone Receptor (TSHR) and Vascular Adhesion Protein-1 (VAP-1) as Potential Diagnostic Biomarker.","authors":"Raghad N Shihab, Atheer Abd Elqader Zain Elabdeen, Samar Ahmed Jabbar","doi":"10.31557/APJCP.2025.26.3.995","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.995","url":null,"abstract":"<p><strong>Background: </strong>Thyroid cancer is a prevalent endocrine malignancy, and identifying reliable molecular markers is crucial. This study evaluates the diagnostic potential of the thyroid-stimulating hormone receptor (TSHR) and vascular adhesion protein-1 (VAP-1).</p><p><strong>Materials and methods: </strong>A total of 90 patients with thyroid disorders including malignant tumors, benign tumors, and hyperthyroidism were recruited from the Al-Amal National Hospital for Cancer Management in Baghdad (March-June 2022). Twenty-five age-matched healthy individuals served as controls. Serum levels of T3, T4, TSH, and thyroglobulin (Tg) were measured along with TSHR and VAP-1 using commercial sandwich ELISA kits.</p><p><strong>Results: </strong>Patients with thyroid cancer exhibited significantly elevated levels of T3 and T4, as well as markedly increased Tg concentrations, compared to controls. In contrast, TSH levels were significantly reduced (P < 0.001). Notably, VAP-1 levels were significantly lower in thyroid cancer patients when compared with both healthy controls and patients with other thyroid disorders (P < 0.001), while TSHR levels did not differ significantly among the groups.</p><p><strong>Conclusion: </strong>The distinct hormonal profile observed characterized by increased T3, T4, and Tg, alongside a significant reduction in VAP-1 suggests that low serum VAP-1 may serve as a useful diagnostic marker for thyroid cancer. These findings underscore the complex interplay between thyroid function and tumor biology and warrant further investigation into the molecular mechanisms underlying these alterations.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"995-1000"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Exercise on Quality of Life among Patients and Survivors of Breast Cancer: A Systematic Review and Meta-Analysis.","authors":"Bhupesh Gupta, Kirtika Gupta, Kashish Narula, Prerna Sharma, Anshu Mittal","doi":"10.31557/APJCP.2025.26.3.715","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.3.715","url":null,"abstract":"<p><strong>Introduction: </strong>The impact of physical activity on the quality of life in breast cancer patients and survivors is examined in this study by a comprehensive meta-analysis of randomized control trials. Materials and procedures: We searched databases like PubMed, Scopus, Embase, and Google Scholar for research publications published between 2005 and 2024, using the PRISMA guidelines. R software was utilised to perform the meta-analysis, and Cochrane's ROB 2.0 tool was employed to assess the quality of the studies. We utilised the I2 statistics to evaluate heterogeneity. A funnel plot and Egger's regression test were used to determine publication bias.</p><p><strong>Results: </strong>The pooled effect of training on overall health-related quality of life (HRQOL) in survivors and patients of breast cancer was estimated to have been 0.70 (CI = 95%: 0.41-0.99) using a random effects model. HRQOL was calculated using Functional Assessment of Cancer Therapy-Breast (FACT-B) outcomes in breast cancer survivors and patients with cancer following giving them physical training and fitness intervention. The downward trend in the meta-regression study suggests that younger people benefited more from exercise in terms of quality of life than older patients. Participants in Asia [1.72 (CI = 95%: -0.60-4.05)], America [0.52 (CI = 95%: 0.30-0.74)], and Australia [0.43 (CI = 95%: 0.24-0.61)] had a stronger effect of the treatment compared to patients in Europe [0.51 (CI = 95%: -0.12-1.15)], according to sub-group analysis.</p><p><strong>Conclusion: </strong>Physical activity enhances breast cancer patients' and survivors' health-related quality of life.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"715-723"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}