Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Serum Level of MVIH, HNF1A-AS1, and NEAT1 Long Noncoding RNAs: Potential Biomarkers for Colorectal Cancer.","authors":"Mohsen Mohamadnejad, Mohammad-Reza Firoozi, Shahriar Hashemzadeh, Venus Zafari, Habib Zarredar, Rojin Farzaneh, Negar Pedram, Touraj Asvadi Kermani","doi":"10.31557/APJCP.2025.26.6.1953","DOIUrl":"10.31557/APJCP.2025.26.6.1953","url":null,"abstract":"<p><p>Long noncoding RNAs (lncRNAs) are a significant class of non-coding RNAs that play critical roles in cancer development, progression, and metastasis. This study aimed to investigate the expression of MVIH, HNF1A-AS1, and NEAT1 in the blood samples of patients with colorectal cancer (CRC), both before and three months after surgery, in comparison to a healthy control group. The objective was to assess the potential of these genes as biomarkers for CRC. A total of 75 blood samples were collected from patients diagnosed with colorectal carcinomas (before surgery and at the three-month post-surgery mark), while an additional 75 samples were obtained from a healthy control group. The relative expression levels of the target genes in the serum were measured using quantitative real-time PCR. Our findings demonstrated that the levels of MVIH, HNF1A-AS1, and NEAT1 in the serum were significantly upregulated in CRC subjects compared to the healthy controls. Receiver operating characteristic (ROC) curve analysis revealed that the serum levels of all three genes could effectively distinguish CRC cases from controls with notable accuracy. Furthermore, the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 were significantly downregulated three months after surgery. However, no significant correlations were observed between the serum levels of the studied genes and the clinical features of the patients. Collectively, our results suggest that the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 have the potential to serve as valuable biomarkers for the diagnosis and prognosis of CRC.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"1953-1958"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Chemotherapy Waiting Time in the Day Care Unit for Gastrointestinal Cancer Patients: A Lean Six Sigma Approach.","authors":"Muath Dayeh, Balaqis Al Faliti, Ikram Burney, Salim AlDhahli, Mohamed El Kholy, Sara Al Sheedi, Ahmad Al Ghoche, Muna AlBalushi, Ossayed Al Awor, Khader Abukoukash, Wesam Ibrahim, Souad Al Maalouf, Mohamad Majed, Abdulaziz AlBadi, Rawan Ibrahim, Hamed Al Amri, Amna Al-Hashar, Razzan Al Zadjali, Huda Al-Awaisi, Khalid Al-Baimani, Eyad AlMadhoun, Nasr Al Riyami, Omar Ayaad","doi":"10.31557/APJCP.2025.26.6.2247","DOIUrl":"10.31557/APJCP.2025.26.6.2247","url":null,"abstract":"<p><strong>Background: </strong>Delays in chemotherapy waiting in a day care unit (DCU) can lead to heightened patient anxiety, and reduced satisfaction, and unnecessary delays for the staff.</p><p><strong>Purpose: </strong>This study aimed to optimize chemotherapy initiation times for cancer patients by addressing inefficiencies and enhancing process reliability.</p><p><strong>Methods: </strong>The study was conducted in a DCU at a dedicated cancer center. Patients attending the gastrointestinal cancer program were selected. A pre-and post-one group design was employed to compare metrics before and after the intervention.  Implementing the Lean Six Sigma (LSS), principles, and using the DMAIC (Define, Measure, Analyze, Improve, Control) approach, we collected baseline data, identified bottlenecks, and implemented targeted solutions. A multidisciplinary team of nursing staff, physicians, and administrators collaborated on the project. The study was approved by the institutional research and ethics committee.</p><p><strong>Results: </strong>Key interventions included the introduction of fast-track and normal-track pathways based on lab readiness, transitioning from round-based to clinic-based evaluations, optimizing patient and staff workflows, standardizing diagnostic processes, and addressing systemic issues such as network outages and resource shortages. The mean time for chemotherapy waiting decreased from 188.4 minutes to 128 minutes, reflecting a substantial improvement in process efficiency. Variability and outliers were notably reduced, as evidenced by improvements in process capability indices. The Process Potential Index (Pp) increased from 0.76 to 0.86, indicating better overall consistency in the process, while the Process Performance Index (Ppk) rose from -0.05 to 0.52, reflecting improved alignment with specification limits and reduced variability. Additionally, the percentage of cases outside the specification limits dropped significantly from 60.6% to 7.3%, demonstrating enhanced process reliability. The Defects Per Million Opportunities (DPMO) decreased dramatically from 606,060.6 to 72,727.3, highlighting a considerable reduction in defects and inefficiencies.</p><p><strong>Conclusion: </strong>Implementing LSS principles successfully reduced chemotherapy waiting times and enhanced process efficiency in the DCU. These findings demonstrate the potential of LSS to address systemic inefficiencies and improve patient-centered outcomes in healthcare. Future efforts should focus on expanding these methodologies to other areas and incorporating advanced technologies to sustain improvements.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"2247-2256"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Contraceptives Use and Colorectal Cancer Risk Among Moroccan Women: A Case-Control Study.","authors":"Hamza Elbaylek, Soumia Ammor","doi":"10.31557/APJCP.2025.26.6.2225","DOIUrl":"10.31557/APJCP.2025.26.6.2225","url":null,"abstract":"<p><strong>Objective: </strong>Colorectal cancer (CRC) encompasses both non-modifiable and modifiable risk factors. While diet remains the main factor influencing CRC risk, hormonal and reproductive factors have also demonstrated a potential impact on CRC risk. This study aims to explore the relationship between oral contraceptives (OC) use and Colorectal cancer risk among Moroccan women.</p><p><strong>Methods: </strong>We conducted a case-control study included 300 participants, divided into 150 cases and 150 controls matched by age (± 3 years). Through a face-to-face interview with trained investigators, we collected data on oral contraceptives use among participants. we performed conditional logistic regression to estimate Odds Ratio (OR) and 95% confidence interval (95% CI), to elaborate a basic model and adjusted model for confounding factors to assess the relationship between OC use and CRC risk.</p><p><strong>Results: </strong>An inverse correlation was observed between OC use and CRC risk with OR²:0.57 (0.36-0.92), using OC at younger ages (≤24 years) for a longer period (>8 years) was also associated with a decreased risk of CRC, with OR²: 0.52 (0.31-0.89) and OR²: 0.43 (0.26-0.79), respectively. this association was consistent across all tumor location in the adjusted model, with OR²: 0.54 (0.27-0.98) for colon cancer, OR²: 0.47 (0.21-0.96) for rectal cancer, and OR²: 0.35 (0.12-0.9) for colorectal cancer. Furthermore, combined oral contraceptives use significantly reduced CRC risk, with OR²: 0.42 (0.21-0.75), whereas no significant reduction was observed with progestin-only pills with OR²: 0.64 (0.32-1.17).</p><p><strong>Conclusion: </strong>These findings underscore the potential role of reproductive and hormone factors, such as oral contraceptive use, in reducing colorectal cancer risk, particularly for combined oral contraceptives initiated in a younger age, also the importance of incorporating reproductive and hormone factors in future research in Morocco, providing a broader understanding of colorectal cancer prevention strategies.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"2225-2232"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Associated Factors of Depressive Symptoms among Informal Caregivers of Patients with Advanced Cancer who Received Palliative Care in Sri Lanka.","authors":"Eranthi Bimalee Weeratunga, Sampatha Goonewardena, Lalitha Meegoda","doi":"10.31557/APJCP.2025.26.6.1997","DOIUrl":"10.31557/APJCP.2025.26.6.1997","url":null,"abstract":"<p><strong>Objective: </strong>Cancer is a challenging health problem, and has a significant impact on informal caregivers (ICs) on their day-to-day responsibilities. This study aimed to determine the prevalence of depressive symptoms (DSs) and its associated factors among ICs of patients with advanced cancer who received palliative care at the Apeksha Hospital Maharagama (AHM), Sri Lanka.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 226 conveniently selected ICs at the AHM, Sri Lanka. Data were collected using an interviewer-administered questionnaire and a validated 20-item Center for Epidemiological Studies-Depression (CES-D) scale. Ethical and institutional approval was obtained. Data analysis was done using descriptive statistics, Chi-square, one-way analysis of variance, Pearson correlation, and independent t-tests.</p><p><strong>Result: </strong>The mean age (±SD) of the ICs was 41.78(±14.54) years. Most of the ICs were females (60%), married (72%), and educated up to secondary level (83%). Prevalence of DSs (≥16) was 49%. Significantly higher DSs were reported by females vs. males (20.52±9.65 vs. 14.74±3.75) and currently unemployed vs. employed ICs (19.69±9.14 vs. 16.58±7.02). DSs were significantly associated with caregiver relationship with the patient (p<0.01), caregiving hours/week (p<0.01), caregiving period (p<0.05), emotional strain (p<0.01), financial strain (p<0.01), and self-reported general health (p<0.01). There was a negative relationship between DSs, perceived social support (r= -0.245; p<0.01), and family/friends support (r= -0.183; p<0.01) of ICs. Further, female gender (p<0.01) and cancer type (p<0.05) of patients were significantly influenced by the DSs of ICs.</p><p><strong>Conclusion: </strong>Almost half of ICs had higher DSs. Some variables related to caregivers, caregiving, and patients are significantly impacted by DSs. Providing psycho-social support for ICs is crucial and recommended educational intervention to provide knowledge and practice on caregiving to reduce depressive symptoms.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"1997-2007"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, Trends and Survival of Oral Cavity Squamous Cell Carcinoma in Aotearoa New Zealand over 15 Years (2006-2020).","authors":"Thu Thu Win Myint, Nick McIvor, Richard Douglas, Alana Cavadino, Mark Elwood","doi":"10.31557/APJCP.2025.26.6.2015","DOIUrl":"10.31557/APJCP.2025.26.6.2015","url":null,"abstract":"<p><strong>Background: </strong>Over recent decades, there have been changes in the incidence of squamous cell carcinoma of the oral cavity (OCSCC) in many countries. However, recent data on OCSCC in New Zealand has not been examined. This study examines the current incidence, trends and survival of OCSCC in New Zealand and identifies demographic differences by age, sex and ethnicity.</p><p><strong>Method: </strong>Patients with a primary diagnosis of OCSCC between 2006 and 2020 were retrieved from the National Cancer Registry. Age-standardised incidence rates (ASRs) were calculated and compared using age-standardised incidence rate ratios (ASRRs). Time trends were assessed by joinpoint regression with annual percentage changes, and overall and relative survival rates were estimated.</p><p><strong>Results: </strong>Over 15 years, 2094 cases of OCSCC were identified, and the average annual incidence was 2.1 per 100,000. The rates were higher in males (ASRR= 1.4 compared to females), older age groups (ASRR=11.3 in 50-69 years; ASRR=25.4 in 70+ years compared to <50 years), and Pasifika (ASRR=1.4, compared to European). OCSCC incidence increased significantly between 2009 and 2017 and decreased between 2017 and 2020. Females followed the same pattern of trends as overall OCSCC, while trends in males showed no significant changes. The survival outcome of OCSCC at five years was 57% and 66% for absolute and relative survival, respectively. Survival outcomes were poorer in males (HR = 1.20 compared to females), older age groups (HR=1.77 in 50-69 years; HR=4.21 in 70+ years compared to <50 years), Māori (HR=1.37 compared to European) and tumours originated from the floor of mouth (HR=1.40), palate (HR=1.47) and buccal (HR=1.54) compared to tongue.</p><p><strong>Conclusion: </strong>This study shows that the incidence of OCSCC overall and in females increased from 2009 to 2017, but declined significantly after 2017 in New Zealand. Incidence and survival rates are influenced by sex, age, ethnicity and subsite.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"2015-2023"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Moringa Oleifera Ethanol Extract on Improving Cisplatin Induced Liver Cells Damages.","authors":"Brigitte Rina Aninda Sidharta, Bambang Purwanto, Brian Wasita, Vitri Widyaningsih, Soetrisno Soetrisno, Risya Cilmiaty, Tonang Dwi Ardyanto","doi":"10.31557/APJCP.2025.26.6.2175","DOIUrl":"10.31557/APJCP.2025.26.6.2175","url":null,"abstract":"<p><strong>Objective: </strong>Cisplatin, a widely used therapy for solid tumors, is associated with hepatotoxicity characterized by cytoplasmic vacuolization of liver cells, sinusoidal congestion, mononuclear and Kupffer cell infiltration, and focal necrosis. Moringa oleifera (M. oleifera) leaves, rich in flavonoids with antioxidant properties, may mitigate hepatotoxicity. This study aimed to evaluate the effects of ethanol extract of M. oleifera leaves on inflammation, oxidative stress, and liver cell damage in a rat model of cisplatin-induced hepatotoxicity.</p><p><strong>Methods: </strong>Thirty male Sprague-Dawley rats were divided into 11 groups, including controls and treatment cohorts. Cisplatin (5 mg/kgBW) was administered as a single dose, followed by a 28-day observation. M. oleifera was administered daily at doses of 300, 600, and 1200 mg/kgBW using three regimens: pre-treatment (7 days prior to cisplatin), concurrent treatment (simultaneously with cisplatin), and post-treatment (7 days after cisplatin). On day 28, blood samples were analyzed for alanine aminotransferase (ALT), malondialdehyde (MDA), and nuclear factor kappa beta (NF-κβ), while liver tissues were assessed for cysteine-aspartic proteases (caspase)-3 levels and histopathological changes.</p><p><strong>Results: </strong>Pre-treatment with M. oleifera demonstrated the most effective reduction in liver damage, with the 1,200 mg/kgBW dose yielding optimal protective effects across all parameters. Significant differences (p < 0.05) were observed in all measured variables across the treatment groups and dosing regimens.</p><p><strong>Conclusion: </strong>M. oleifera exhibits a dose-dependent ability to mitigate inflammation, oxidative stress, and liver cell damage caused by cisplatin. The pre-treatment regimen with M. oleifera was the most effective.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"2175-2183"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Olaparib, Niraparib, Rucaparib therapies on Newly Diagnosed and Relapsed Ovarian Cancer -Systematic Review and Meta-Analysis.","authors":"Seeta Devi, Ramesh Chandrababu","doi":"10.31557/APJCP.2025.26.6.1931","DOIUrl":"10.31557/APJCP.2025.26.6.1931","url":null,"abstract":"<p><strong>Objective: </strong>This review aims to examine the effect of PARP inhibitors on PFS, OS, and adverse events in women with advanced ovarian cancer (OC).</p><p><strong>Methods: </strong>The PRISMA 2020 guidelines are followed while conducting this comprehensive review. Data from 17 randomized control trails (RCT) published between 2014 and June 2024 were included. These trials compared PARPi maintenance therapy to placebo women with newly diagnosed and recurrent advanced OC. The specific keywords were used to search relevant studies in databases including PubMed, SCOPUS, Cochrane library, and WoS. The main outcomes were the Progression free survival (PFS), overall survival (OS), or adverse events (AEs). The combined hazard ratios (HRs) and risk ratios (RRs) were determined, together with 95% confidence intervals (CIs). Each of the analyses were conducted using a model with random effects.</p><p><strong>Results: </strong>Despite high heterogeneity, the meta-analysis found that poly (ADP-ribose) polymerase inhibitors (PARPi) maintenance therapy ominously improved PFS compared to placebo, with a combined HR of 1.33 (95% CI: 1.10-1.61) in newly diagnosed cases and 0.88 (95% CI: 0.59-1.30) in relapsed cases. However, the OS improvement was not significantly substantial, with a collective HR of 1.06 (95% CI: 0.99-1.13). AEs are considerably higher in the PARPi groups, notably hematologic toxicities including anaemia, thrombocytopenia, and neutropenia. However, these adverse effects may be controlled with dosage modifications, and therapy was discontinued only in few cases.</p><p><strong>Conclusion: </strong>PARPi are an effective therapy in both newly discovered and relapsed. Although there is a modest rise in the frequency of severe adverse reactions, they are usually handled well.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"1931-1941"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant property of Silver Nanoparticles Loaded with Alcoholic Extraction of Lycium Shawii.","authors":"Ali Noory Fajer, Meaad Nasser Hussein, Yusra Sebri Abdulsaheb","doi":"10.31557/APJCP.2025.26.6.2197","DOIUrl":"10.31557/APJCP.2025.26.6.2197","url":null,"abstract":"<p><strong>Background: </strong>Antioxidants play a crucial role in mitigating oxidative stress associated with cancer progression. Lycium shawii is noted for its high content of antioxidants and anti-inflammatory compounds. Silver nanoparticles (AgNPs) hold a prominent position among the various nanoparticles synthesized and characterized to date.</p><p><strong>Objective: </strong>In this study, we aimed to synthesize and characterize AgNPs loaded with alcoholic extracts of Lycium shawii and evaluate their antioxidant effects in vivo.</p><p><strong>Methods: </strong>Thirty rats were randomly divided into five groups, with six rats in each group. Group 1 (Control) was administered 1 mL of normal saline orally via a stomach tube daily. Group 2 received 1 mL of AgNPs at a dosage of 100 mg/kg on the day of administration. Group 3 was treated with 1 mL/day of Acetamiprid at a dosage of 25 mg/kg. Group 4 was given AgNPs (100 mg/kg) for three weeks, followed by Acetamiprid (25 mg/kg) for an additional three weeks. Group 5 received Acetamiprid (25 mg/kg) for three weeks, followed by AgNPs (100 mg/kg). All treatments were administered daily, and serum levels of T-AOC, TOS, as well as the biomarkers AST, ALT, urea, and creatinine, were evaluated across all groups.</p><p><strong>Results: </strong>The results of the study demonstrated a significant increase in TOS, ALT, AST, urea, and creatinine, as well as a significant decrease in T-AOC (p ≤ 0.05) in Group 3 compared to Groups 1, 2, 4, and 5.</p><p><strong>Conclusion: </strong>The in vivo results demonstrate that AgNPs, especially when combined with Lycium shawii extracts, exhibit significant antioxidant properties, suggesting a protective role against oxidative damage. These findings support the therapeutic potential of AgNPs in cancer treatment and oxidative stress-related disorders. Future studies are needed to fully elucidate the molecular mechanisms underlying the observed antioxidant effects and to assess the long-term safety and efficacy of AgNPs in clinical applications.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"2197-2204"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Gaps in Cancer Screening Research: A Call for Methodological Precision.","authors":"Sana Anwar, Anindo Majumdar, M Sushma Yadav","doi":"10.31557/APJCP.2025.26.6.1869","DOIUrl":"10.31557/APJCP.2025.26.6.1869","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"1869-1870"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer Influence and Use of Electronic Cigarettes among Adolescents and Young Adults: A Meta-Analysis of Prospective Studies.","authors":"Ngoc-Minh Luu, Thi-Tra Bui, Hai Thanh Phan, Jin-Kyung Oh","doi":"10.31557/APJCP.2025.26.6.2215","DOIUrl":"10.31557/APJCP.2025.26.6.2215","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between peer use and individual use of EC among adolescents and young adults.</p><p><strong>Methods: </strong>We performed the search strategy on PubMed, EMBASE, and Cochrane. We selected prospective studies reporting adjusted odds ratio (aOR)/relative risk (aRR) with a 95% confidence interval (CI) and conducted a random-effects meta-analysis.</p><p><strong>Result: </strong>Eleven prospective studies were included, involving 32,014 participants in the quantitative analysis. Meta-analysis results showed a significant association between EC use by friends and increased odds of individual EC use (aOR = 1.79, 95% CI 1.43 to 2.25; I2 = 88.2% for ever use; aOR = 2.14, 95% CI 1.52 to 3.01; I2 = 88.5% for current use). In the subgroup meta-analysis of outcomes, having friends who used EC significantly increased the odds of ever- and current EC use. Similar findings were found in the subgroup meta-analyses by age group, region, sample size, study methodological quality, and follow-up time.</p><p><strong>Conclusion: </strong>This study revealed a positive association between individual EC use and friends' use, especially among those under 18 years, suggesting targeting peer networks to curb the EC epidemic.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"2215-2223"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}