Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Analyzing Secondary Cancer Risk: A Machine Learning Approach.","authors":"Erfan Hatamabadi Farahani, Hossein Sadeghi, Fatemeh Seif, Mahdi Azad Marzabadi, Reza Rezaee","doi":"10.31557/APJCP.2025.26.1.239","DOIUrl":"10.31557/APJCP.2025.26.1.239","url":null,"abstract":"<p><strong>Objective: </strong>Addressing the rising cancer rates through timely diagnosis and treatment is crucial. Additionally, cancer survivors need to understand the potential risk of developing secondary cancer (SC), which can be influenced by several factors including treatment modalities, lifestyle choices, and habits such as smoking and alcohol consumption. This study aims to establish a novel relationship using linear regression models between dose and the risk of SC, comparing different prediction methods for lung, colon, and breast cancer.</p><p><strong>Methods: </strong>Machine learning (ML) models have demonstrated their usefulness in forecasting the likelihood of SC risks based on effective doses in the organ. Linear regression analysis is a widely utilized technique for examining the relationship between predictor variables and continuous responses, particularly in scenarios with limited sample sizes. This study employs linear regression models to analyze the relationship between effective dose and the risk of SC, comparing different prediction methods across lung, colon, and breast cancer.</p><p><strong>Result: </strong>The results indicate that the risk of SC increases with the effective dose in the organ. The linear regression model provides coefficients that mirror the radiation sensitivity of the specific organ, demonstrating the model's effectiveness in predicting SC risk based on dose.</p><p><strong>Conclusion: </strong>The study highlights the significance of using linear regression models to predict the risk of SC based on effective doses in the organ. The findings underscore the importance of considering the radiation sensitivity of specific organs in SC risk prediction, which can aid in better understanding and managing the long-term health of cancer survivors.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"239-248"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Education on Nutritional Knowledge of Cancer Prevention based on Health Belief Model: A Systematic Review and Meta-Analysis.","authors":"Amirreza Karimi, Soheyla Kalantari, Fatemeh Hamidi, Mozhgan Taebi, Alimorad Heidari Gorji, Elnaz Malek Mohammadi","doi":"10.31557/APJCP.2025.26.1.33","DOIUrl":"10.31557/APJCP.2025.26.1.33","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review was conducted to examine the impact of education on nutritional knowledge for cancer prevention using the Health Belief Model.</p><p><strong>Methods: </strong>Comprehensive searches were performed in international electronic databases, including Scopus, PubMed, and Web of Science, from their inception until June 16, 2024. Keywords derived from Medical Subject Headings such as \"Nutrition Knowledge,\" \"Education,\" \"Health Belief Model,\" and \"Cancer\" were utilized. Additionally, Iranian databases like Iranmedex were searched. The quality of randomized controlled trials (RCTs) and quasi-experimental studies was assessed using the Joanna Briggs Institute's (JBI) critical assessment checklist.</p><p><strong>Results: </strong>A total of 611 participants were enrolled in five studies. Among these participants, 78.39% were female, and 76.76% were in the intervention group. The mean age of participants was 42.12 years (SD = 6.47). The mean follow-up period was approximately 14 weeks, and the average duration of the intervention was 54 minutes. The findings indicated that education based on the Health Belief Model was effective in increasing nutritional knowledge. The meta-analysis revealed a significant improvement in nutritional knowledge among participants who received HBM-based education, with a pooled SMD of 0.75 (95% CI: 0.52-0.98, p < 0.001), indicating a moderate-to-large effect size. The intervention group demonstrated increased knowledge scores compared to controls, with an average follow-up period of 14 weeks and intervention duration of approximately 54 minutes per session.</p><p><strong>Conclusion: </strong>Health professionals, such as nurses, can utilize this model to enhance nutritional knowledge. It is recommended that health managers and policymakers create environments that enable health professionals to employ educational strategies based on the Health Belief Model, thereby improving nutritional knowledge.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Dentist-based Anti-Smoking Intervention Among Malaysian Adolescents: A Randomized Controlled Field Trial.","authors":"Nawwal Alwani Mohd Radzi, Zamros Yuzadi Mohd Yusof","doi":"10.31557/APJCP.2025.26.1.161","DOIUrl":"10.31557/APJCP.2025.26.1.161","url":null,"abstract":"<p><strong>Background: </strong> The KOTAK program is a national public health initiative in Malaysian primary and secondary schools aimed at reducing youth smoking through school dental services. This study evaluated its effectiveness in Seremban, Negeri Sembilan, Malaysia.</p><p><strong>Objectives: </strong>1) To determine the percentage of schoolchildren who quit smoking through the KOTAK program; 2) To identify factors associated with quitting smoking in the program.</p><p><strong>Methods: </strong>A clustered, randomized controlled trial was conducted in schools. Self-reported smokers meeting inclusion criteria were enrolled. Data on demographics, self-reported smoking abstinence, and nicotine addiction levels were collected at baseline, three months, and six months post-intervention. Exhaled carbon monoxide was measured at all time points, and salivary cotinine was collected at three- and six-month follow-ups.</p><p><strong>Results: </strong>Six months post-intervention, 29.8% of students in intervention schools and 14.6% in control schools reported quitting smoking. The odds of quitting were higher with the KOTAK program (aOR = 2.25, 95% CI = 1.11-4.57). Factors such as age, maternal education, and baseline nicotine addiction level were protective for smoking abstinence.</p><p><strong>Conclusion: </strong>The intervention group showed a higher self-reported smoking cessation rate, indicating the potential efficacy of the KOTAK program.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Genetic Polymorphisms Related GSTM1, GSTT1, GSTP1 Genes and their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients.","authors":"Anand K Gudur, Rashmi A Gudur, Suresh J Bhosale, Kailas D Datkhile","doi":"10.31557/APJCP.2025.26.1.49","DOIUrl":"10.31557/APJCP.2025.26.1.49","url":null,"abstract":"<p><strong>Background: </strong>In this study we explored the association of polymorphisms of glutathione s transferase gene including GSTM1, GSTT1 and GSTP1 with adverse acute normal tissue reactions resulted from radiotherapy in HNC patients. We assessed the association of GSTM1 and GSTT1 null genotypes and Ile105Val of exon-5 and Ala114Val of exon-6 of GSTP1 gene polymorphisms with the risk of acute skin toxicity reactions after therapeutic radiotherapy in HNC patients.</p><p><strong>Methods: </strong>Four hundred HNC patients administered with Intensity modulated radiation therapy were enrolled in this study for the evaluation of radiotherapy associated toxicity reactions. The genotyping of GSTM1 and GSTT1 were performed by polymerase chain reaction (PCR). The GSTP1 Ile/Val of exon-5 and Ala/Val of exon-6 polymorphism was determined by PCR followed by restriction fragment length polymorphism (PCR-RFLP).</p><p><strong>Results: </strong>The univariate logistic regression analysis showed that GSTM1 and GSTT1 null genotypes were not associated with either skin reaction or oral mucositis in response to radiotherapy induced after effects. When we studied, A313G polymorphism at exon 5 and C341T polymorphism at exon 6 of GSTP1 gene, majority of genotypes were wild type A/A genotype for exon 5 showed non-significant association with Skin reactions whereas, C/T genotype of exon-6 showed significant negative association with skin reactions.</p><p><strong>Conclusion: </strong>The findings obtained from this study concluded that the null genotypes of GSTM1 and GSTT1 gene polymorphisms showed no association with radiotherapy induced acute toxicities such as dermatitis and oral mucositis. The results indicated negative association of heterozygous C/T genotype of exon-6 of GSTP1 with acute skin reactions.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Electronic and Conventional Cigarette Use towards Saliva Profile and Oral Microbiota in Adolescents.","authors":"Angelita Victoria Kurniawan, Rahmi Amtha, Indrayadi Gunardi, Alyah Heriandi, Elizabeth Fitriana Sari","doi":"10.31557/APJCP.2025.26.1.309","DOIUrl":"10.31557/APJCP.2025.26.1.309","url":null,"abstract":"<p><strong>Objective: </strong>To compare the salivary profiles of smokers (e-cigarette smokers, e-cigarette and former conventional cigarette smokers, dual users, and conventional cigarette smokers) and non-smokers in adolescents, focusing on acidity level, flow rate, viscosity, as well as the quantity of Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans.</p><p><strong>Methods: </strong>This analytical observational study, with a cross-sectional design, involves collecting saliva samples from five groups through the draining method. Saliva viscosity was assessed visually, while saliva flow rate was monitored over a ten-minute period. Quantification of bacterial presence was performed using qPCR, and salivary acidity was determined using a digital pH meter. Chi square and t-test were used to analyze the data.</p><p><strong>Result: </strong>The total of 390 subjects (smokers n=195; non-smokers n=195), aged 17-25 years, participated in the study. Dual smokers exhibited a notable decrease in salivary pH (p=0.039) compared to non-smokers. Furthermore, significant reductions in flow rate (p<0.001) were observed across the five groups, however, no significant differences were found in saliva viscosity (p=0.070). When considering the four groups excluding conventional cigarette smokers, significant differences were observed in the quantity of Porphyromonas gingivalis (p=0.010) and Candida albicans (p=0.005). Conversely, the prevalence of Streptococcus mutans did not exhibit a significant difference (p=0.635).</p><p><strong>Conclusion: </strong>The study demonstrates that salivary pH, flow rate, and quantity of P. gingivalis as well as C. albicans are significantly different among the five groups.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"309-318"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker Panels Associated with Diagnosis and Overall Survival in Hepatocellular Carcinoma Revealed from Protein-Protein and mRNA-miRNA Interaction Networks.","authors":"Reyhaneh Farrokhi Yekta, Mostafa Rezaei Tavirani, Afsaneh Arefi Oskouie, Nasrin Amiri-Dashatan","doi":"10.31557/APJCP.2025.26.1.249","DOIUrl":"10.31557/APJCP.2025.26.1.249","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC), the most common form of liver cancer, has a significant mortality rate, largely due to late diagnosis. Recent advances in medical research have demonstrated the potential of biomarkers for early detection. Moreover, the discovery and use of prognostic biomarkers offer a ray of hope in the fight against liver cancer.</p><p><strong>Methods: </strong>Three gene transcript collections (GSE57957, GSE76427, and GSE84402) were retrieved from the GEO database, and significantly expressed genes were identified through a comprehensive screening process. Subsequently, key potential biomarkers were identified using various methods, including functional pathway enrichment, protein-protein interaction network analysis, mRNA-miR interaction study, and ROC curve and survival analysis.</p><p><strong>Results: </strong>After analyzing the expression of hub proteins and miRs, 12 proteins were found to have AUC values greater than 0.9 and log-rank KM-plot p values less than 0.05. Therefore, these proteins can be considered as potential diagnostic and prognostic biomarkers. Among these proteins, the top 5 were CDC6, PTTG1, CDCA5, RACGAP1, and RAD51AP1. The microRNAs with the highest diagnostic significance (AUC≥0.8) were hsa-mir-101-3p, hsa-mir-195-5p, hsa-mir-130a-3p, hsa-mir-26b-5p, hsa-mir-29c-3p, hsa-mir-26a-5p, and hsa-mir-34a-5p. Notably, hsa-mir-34a-5p, hsa-mir-195-5p, and hsa-mir-130a-3p also showed prognostic potential as predictors of overall survival in HCC patients.</p><p><strong>Conclusion: </strong>Harnessing the potential of these biomarkers will enable healthcare professionals to make informed decisions, leading to improved care and more favorable outcomes in the fight against HCC. However, the next step is to thoroughly validate these potential markers in large cohorts.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"249-262"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"F-18 FDG PET/CT based Preoperative Machine Learning Prediction Models for Evaluating Regional Lymph Node Metastasis Status of Patients with Colon Cancer.","authors":"Su Jung Choi, Ji Sun Park, Hyung Joo Baik, Min Sung An, Ki Beom Bae, Sun Seong Lee","doi":"10.31557/APJCP.2025.26.1.85","DOIUrl":"10.31557/APJCP.2025.26.1.85","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop a simple machine-learning model incorporating lymph node metastasis status with F-18 Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and clinical information for predicting regional lymph node metastasis in patients with colon cancer.</p><p><strong>Methods: </strong>This retrospective study included 193 patients diagnosed with colon cancer between January 2014 and December 2017. All patients underwent F-18 FDG PET/CT and blood test before surgery. One categorical variable (lymph node FDG uptake [LNFDG]) and six continuous variables (age, neutrophil-to-lymphocyte ratio [NLR], carcinoembryonic antigen [CEA], carbohydrate antigen 19-9 [CA19-9], C-reactive protein, and maximal standardized uptake value (SUVmax) of the primary tumor) were used as input variables. Four supervised machine learning methods were used to build predictive models: logistic regression (LR), random forest (RF), gradient boosting machine (GBM), and support vector machine (SVM). Area under the receiver operating characteristic curve (AUC) of the validation set were used for evaluating and comparing model performance.</p><p><strong>Results: </strong>The number of patients with lymph node metastasis were 63 (33%). The mean number of harvested lymph nodes was 28.8 ± 11.4. The mean CEA, CA19-9, and CRP levels were 4.8 ± 9.3 ng/ml, 15.6 ± 42.8 U/ml, and 1.0 ± 3.0 mg/dl, respectively. The mean NLR was 2.2 ± 1.2. The mean SUVmax levels of the primary tumor were 15.2 ± 7.9. Fifty-one (26%) patients showed FDG uptake in the pericolic lymph nodes.  The mean AUC of the LR, RF, GBM, and SVM methods for the LNFDG model was 0.7046, 0.7047, 0.7040, and 0.7058, respectively. The mean AUC of the LR, RF, GBM, and SVM methods for the LNFDG plus clinical information model was 0.7046, 0.7302, 0.7444, and 0.7097, respectively.</p><p><strong>Conclusion: </strong>Machine learning methods using LNFDG and clinical information could predict the lymph node metastasis status in patients with colon cancer with higher accuracy than a model using only FDG uptake of the lymph nodes.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Clinical Relevance of Procoagulant Microparticles as Biomarkers of Blood Coagulation in Breast Cancer: A Systematic Review.","authors":"Marzieh Haghbin, Abdolreza Sotoodeh Jahromi, Akbar Hashemi Tayer, Zahra Ghasemi Nejad","doi":"10.31557/APJCP.2025.26.1.23","DOIUrl":"10.31557/APJCP.2025.26.1.23","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) is a global challenge that affects a large portion of individuals, especially women. It has been suggested that microparticles (MPs) can be used as a diagnostic, prognostic, or therapeutic biomarker in various diseases. Moreover, MPs are known to elevate in cancer cases. Platelet-derived MPs (PMPs) play a crucial role in the metastasis of BC, warranting specific focus. This study aimed to explore the involvement of procoagulant MPs in BC.</p><p><strong>Methods: </strong>This systematic review was carried out using the Preferred Reporting Items for Systematic reviews, and Meta-Analyses (PRISMA). Terms defined as MESH keywords were searched PubMed/MEDLINE, Embase, Web of Science, and Cochrane Library searched in from 2011 to March 2024. Experimental and quasi-experimental studies were assessed by the CONSORT checklist.</p><p><strong>Results: </strong>Eventually, 15 studies were included. 426 participants were studied in the included articles. The potential clinical relevance of MPs as biomarkers in BC was indicated. Also, the role of MPs in immune modulation and multidrug resistance was approved. PMPs were found to enhance malignant features, including migration and invasion. Moreover, there were lower levels of MPs before neo-adjuvant chemotherapy, suggesting a potential impact of chemotherapy on MPs levels. The study highlights the remarkable capacity of multidrug-resistant BC-derived MPs to alter the phenotype and functionality of immune cells.</p><p><strong>Conclusions: </strong>The findings underscore the intricate interplay between MPs and cellular signaling pathways, shedding light on their potential as diagnostic biomarkers, and therapeutic targets in cancer. Specifically, the association between MPs levels and disease severity, as evidenced by their correlation with tissue-based biomarkers, tumor grading, and distant metastasis, highlights their clinical relevance in prognostication and risk stratification.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"23-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8-OHdG and Nrf2 Protein are Expressed Consistently in Various T Stages of Invasive Breast Carcinoma.","authors":"Fira Soraya, Willy Sandhika, Priangga Adi Wiratama","doi":"10.31557/APJCP.2025.26.1.301","DOIUrl":"10.31557/APJCP.2025.26.1.301","url":null,"abstract":"<p><strong>Objective: </strong>Oxidative stress prompts breast cancer cells to adapt by raising the lethal threshold and enhancing the antioxidant mechanism, thereby enabling survival and continuous proliferation that facilitates tumor progression. Nrf2 and 8-OHdG are indicative of oxidative stress activity and impact the progression of breast cancer. We aimed to analyze the expression of Nrf2 and 8-OHdG in various T stages of breast cancer in our hospital.</p><p><strong>Methods: </strong>This observational study employed a cross-sectional design and included patients with invasive breast carcinoma of no special type diagnosis from histopathology examination who underwent modified radical mastectomy without neoadjuvant chemotherapy at Dr. Soetomo General Academic Hospital between January 2019 and December 2022. Medical records and paraffin blocks that met these criteria were obtained. 8-OHdG and Nrf2 were assessed using immunohistochemistry.</p><p><strong>Result: </strong>There was no significant difference and correlation between 8-OHdG (p=0.578) and Nrf2 (p=0.694) expression with various T stages of IBC-NST and no significant correlation between 8-OHdG/Nrf2 expression and T stage (p=0.242 and 0.625 respectively).</p><p><strong>Conclusion: </strong>Consistent expression of 8-OHdG and Nrf2 in various T stages of breast cancer represents a continuation of the oxidative stress process in breast cancer that is not influenced by the tumor size. The existence of consistent oxidative stress at all tumor sizes (T stage) stimulates breast cancer cells to continue proliferating.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"301-307"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Analysis of Programmed Death-1-Trastuzumab Resistance Regulatory Networks in Breast Cancer Cells.","authors":"Adam Hermawan, Herwandhani Putri","doi":"10.31557/APJCP.2025.26.1.279","DOIUrl":"10.31557/APJCP.2025.26.1.279","url":null,"abstract":"<p><strong>Objective: </strong>Programmed cell death-1 (PD-1, encoded by PDCD1) regulatory network participates in glioblastoma multiforme development. However, such a network in trastuzumab-resistant human epidermal growth factor receptor 2-positive (HER2+) breast cancer remains to be determined. Accordingly, this study was aimed to explore the PD-1 regulatory network responsible for the resistance of breast cancer cells to trastuzumab through a bioinformatics approach.</p><p><strong>Methods: </strong>The study used data mining tools like cBioportal and OMIM to identify genes involved in the programmed cell death-1-trastuzumab resistance regulatory network. The network was further examined using various tools like WebGestalt, DAVID, STRING, Cytoscape, CytoHubba, GEPIA, TNMPlot, and ROCPlot.</p><p><strong>Results: </strong>The PDCD1 regulatory network in trastuzumab-resistant HER2+ breast cancer is linked to Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), interleukin (IL)-10, protein tyrosine phosphatase receptor type C (PTPRC), and FCGR2B. These factors have a significant prognostic power in pathological complete response in breast cancer patients treated with trastuzumab. Infiltration of B cells, CD8+ cells, CD4+ cells, neutrophils, dendritic cells, macrophages, and regulatory T cells is directly correlated with PTR expression.</p><p><strong>Conclusion: </strong>The study identified four genes (CTLA4, IL10, PTPRC, and FCGR2B) that are linked to the regulatory network of PD-1 in trastuzumab-resistant HER2+ breast cancer cells. Further research is needed to develop the therapeutic target against trastuzumab resistance in HER2+ breast cancer.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 1","pages":"279-292"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}