Asian Pacific Journal of Cancer Prevention最新文献

{"title":"p53 and β-Catenin Expression in Gallbladder Carcinoma: Translational Insights for Pediatric Cancer Biology.","authors":"Muniba Alim, Mohd Asif Khan, Shamila Alim, Rafey Abdul Rahman","doi":"10.31557/APJCP.2026.27.9.3289","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3289","url":null,"abstract":"<p><strong>Background: </strong>The tumor suppressor p53 and the Wnt pathway effector β-catenin represent two of the most frequently dysregulated molecular components across human malignancies. Although gallbladder cancer (GBC) predominantly affects adults, the pattern and clinicopathological correlates of p53 and β-catenin dysregulation in GBC may illuminate how these pathways behave in different biological contexts, including developmental and pediatric oncological settings, where analogous pathway alterations drive distinct tumor types.</p><p><strong>Objective: </strong>To characterize p53 and β-catenin expression patterns in gallbladder carcinoma by immunohistochemistry, correlate findings with clinicopathological parameters, and discuss in a qualified, hypothesis-generating framework the parallels and divergences between these pathway alterations and those reported in pediatric malignancies.</p><p><strong>Methods: </strong>A cross-sectional study analyzed 61 neoplastic and 49 non-neoplastic gallbladder lesions (2017-2021) using standardized immunohistochemistry for p53 (clone DO-7; Dako/Agilent, 1:100) and β-catenin (clone E247; Abcam, 1:200). Expression patterns were correlated with clinicopathological parameters using chi-square and Fisher's exact tests. Findings were discussed in the context of published pediatric cancer literature, with explicit acknowledgment of inter-study methodological heterogeneity.</p><p><strong>Results: </strong>p53 overexpression (defined as >20% nuclear positivity) occurred in 78.2% of GBC cases versus 11.1% of benign lesions, correlating significantly with tumor grade and stage (p<0.05). Aberrant β-catenin expression (cytoplasmic/nuclear) was observed in 81.8% of malignant cases, with nuclear localization in 36.3%, correlating with poor differentiation. These patterns qualitatively parallel though are not directly quantitatively comparable to those reported in pediatric hepatoblastoma, Wilms' tumor, and pediatric sarcomas.</p><p><strong>Conclusion: </strong>p53 and β-catenin dysregulation in GBC exhibits qualitative parallels to patterns reported in pediatric cancers, suggesting shared oncogenic pathway biology. These observations are hypothesis-generating and warrant validation through functional studies in appropriate preclinical models before therapeutic implications can be drawn.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3289-3297"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time PCR Ct Values of Detection of Epstein-Barr Virus (EBV) EBNA1 Gene in Nasopharyngeal Swab Samples.","authors":"Arroyan Wardhana, Kinasih Prayuni, Intan Razari, Dedy Suseno, Anggi Puspa Nur Hidayati, Wening Sari, Adilah Ulinnuha Al-Fathani, Zuki Saputra, Karisma Prameswari Patria Mahatmi, Handoko Nugroho Yossarsongko, Cita Herawati, Fahreza Saputra, Noorwaty Sutandyo, Lyana Setiawan, Susanti Susanti, Gilang Akbariani, Neni Nurainy, Ahmad Rusdan Handoyo Utomo","doi":"10.31557/APJCP.2026.27.9.3179","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3179","url":null,"abstract":"<p><strong>Objective: </strong>Nasopharyngeal cancer (NPC) is highly prevalent in Asia; however, no established screening program exists to identify high-risk individuals. This study evaluated the potential utility of real-time PCR cycle threshold (Ct) values of Epstein-Barr virus (EBV) DNA detection in nasopharyngeal swabs (NS) as a practical non-invasive screening approach.</p><p><strong>Methods: </strong>Nasopharyngeal cytobrush (CB) and swab (NS) samples were collected from 98 patients with NPC, and NS samples were collected from 174 non-NPC individuals. Real-time PCR targeted the EBNA1 gene, with a Ct cutoff < 35 defined as positive. Beta-globin amplification served as an internal control to verify sample adequacy.</p><p><strong>Results: </strong>In NPC patients, 79% and 81% were EBNA1 positive in CB and NS specimens, respectively. In non-NPC individuals, 10.3% were EBNA1 positive. Median Ct values were 24.4 in NPC patients and 34.4 in non-NPC individuals (p<0.001). Using a Ct cutoff of <35, the diagnostic performance of detecting EBNA1 in NS specimens showed 81% sensitivity, 90% specificity, and 90% accuracy.</p><p><strong>Conclusion: </strong>A real-time PCR Ct cutoff of< 35 for EBNA1 detection provides a practical and effective non-invasive screening tool for NPC in endemic populations. Further validation in prospective cohorts is required.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3179-3184"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Predictors of Awareness of the Kuwait National Mammography Screening Program Among Women in Kuwait: A Cross-Sectional Study.","authors":"Ahmad Salman, Fatima Al-Ghadban, Ahmad Abbas","doi":"10.31557/APJCP.2026.27.9.3487","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3487","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the leading malignancy among women in Kuwait. The Kuwait National Mammography Screening Program (KNMSP), launched in 2014, provides free biennial mammography to asymptomatic women aged 40-69 years; however, participation remains persistently low and awareness is insufficiently characterized. This study aimed to estimate the prevalence of KNMSP awareness and identify its independent predictors across sociodemographic, knowledge, behavioral, and attitudinal domains.</p><p><strong>Methods: </strong>A community-based cross-sectional survey was conducted among 458 women aged ≥20 years residing across all six governorates of Kuwait between January and April 2025, using convenience sampling via social media and community networks. Of 516 women who accessed the questionnaire, 458 met eligibility criteria and completed all items (response rate 88.7%). Standardized validated instruments assessed breast cancer warning-sign knowledge, risk-factor knowledge, screening beliefs, and perceived barriers. Hierarchical multivariable logistic regression identified independent predictors of KNMSP awareness.</p><p><strong>Results: </strong>Overall, 65.3% of participants (n = 299) reported awareness of the KNMSP. In the final adjusted model (Nagelkerke R² = 0.355; AUC = 0.798), knowledge of breast self-examination (BSE) was the strongest independent predictor (OR = 3.60; 95% CI 1.87-6.93; p < 0.001). Women aged 20-29 years (OR = 0.29), unpartnered women (OR = 0.40), and non-Kuwaiti women (OR = 0.47) had significantly lower adjusted odds of awareness. Perceived barriers and screening beliefs were not independently associated with awareness.</p><p><strong>Conclusions: </strong>Two-thirds of women in Kuwait are aware of the KNMSP; however, substantial gaps persist among younger, unpartnered, and non-Kuwaiti women. Integrating BSE education into outreach initiatives, strengthening primary-care referral, and developing multilingual campaigns targeting high-gap subgroups are priority actions to improve program visibility and, ultimately, screening uptake.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3487-3495"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Van Diessen et al. Improved Overall Survival Due to Reduced Waiting Time in Nasopharyngeal Cancer Patients Treated with Chemoradiotherapy in Yogyakarta, Indonesia.","authors":"Erkan Topkan, Ugur Selek","doi":"10.31557/APJCP.2026.27.9.3135","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3135","url":null,"abstract":"","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3135-3137"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practices and Barriers to Early Mobilization in Intensive Care Unit Post Head and Neck Cancer Surgeries: An Observational Study.","authors":"Vaishnavi Puranik, Cherishma Dsilva, Aishwarya Gatty, Rohanchandra Gatty","doi":"10.31557/APJCP.2026.27.9.3169","DOIUrl":"10.31557/APJCP.2026.27.9.3169","url":null,"abstract":"<p><strong>Background: </strong>Head and neck cancer (HNC) is a growing global health concern, with rising incidence in India. Patients undergoing HNC surgery experience postoperative challenges due to altered airway anatomy and complex reconstruction. Enhanced Recovery After Surgery (ERAS) protocols recommend early mobilization (EM) to improve postoperative outcomes; however, its implementation remains inconsistent.  Evidence regarding EM practices in this population is limited. This study aimed to evaluate EM practices and their barriers in post HNC surgery patients in a tertiary care setting.</p><p><strong>Methods: </strong>A prospective observational study was conducted among adults undergoing HNC surgery. Patients with neurological deficits or preoperative non-ambulatory status were excluded. Mobilization was assessed daily until postoperative day (POD) 5 using the ICU Mobility Scale (IMS). Barriers to EM were documented using a validated checklist and categorized into three domains. Logistic regression analyses were performed to identify factors associated with non-ambulatory status (IMS<5). Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were reported. A p<0.05 was considered statistically significant.</p><p><strong>Results: </strong>Among the 69 patients included, 69.6% patients received in-bed exercises, while 27.5% had not been mobilized on POD 1. On POD 3, 23.1% were ambulated with assistance. More than 75% of the patients were ambulated and shifted to the wards by POD 5. Major functional and clinical barrier domains included nasotracheal intubation (75.4%), respiratory distress (53.6%) and free flap reconstruction (28.9%). The system-provider domain included low prioritization of EM (46.4%) and communication gaps among healthcare professionals (7.26%). This domain was independently associated with non-ambulatory status (aOR 0.402, 95% CI 0.172-0.817, p=0.020).</p><p><strong>Conclusion: </strong>EM practices showed a consistent but gradual improvement over the five postoperative days. Though patient related barriers were common, the overall mobility outcomes were mainly determined by the system-provider domain of barriers. Addressing barriers to EM is crucial for enhancing its practice and ensuring adherence to EM protocols.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3169-3178"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Activity of Parotid Gland Toxins from Ingerophrynus philippinicus (Philippine Toad) Against Human Colorectal Carcinoma (HCT-116).","authors":"Jjessmar Bolivar Fama, Hans Joshua Ygrubay, Anne Gwyneth Traya, Nicole Lepardo, Gerlyn Joy Rojo, Bien Adrian Codilla, Ja-An Fernandez, Jireh Rodriguez, Ezabel Lara Lim, Stephen Sabinay, Jose Nemesio Granada","doi":"10.31557/APJCP.2026.27.9.3151","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3151","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer is the third most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Limitations of current treatments include adverse effects and drug resistance, highlighting the need for new chemotherapeutic agents. This study evaluated the cytotoxic activity of crude methanolic extract of the parotid gland secretions of Ingerophrynus philippinicus (PGSE), a toad endemic to the Philippines, against human colorectal carcinoma cell line (HCT-116) and identified its bioactive compounds.</p><p><strong>Methods: </strong>Crude methanolic extract of parotid gland secretions was prepared and evaluated for antiproliferative activity using the MTT assay. An Annexin V/PI assay was used to assess apoptosis and necrosis. The presence of bufadienolides was determined using Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Double Tandem Mass Spectrometry (UPLC-QTOF-MS/MS).</p><p><strong>Results: </strong>The extract exhibited cytotoxic activity against HCT-116 cells in a dose-dependent manner with an IC50 of 4.462 ± 2.141 μg/mL. The Annexin V/PI assay revealed that treated cells predominantly underwent late apoptosis (89.52% ± 2.25%), with smaller proportions of early apoptosis (6.16% ± 2.49%), and necrosis (4.32% ± 0.29%). The UPLC-QTOF-MS/MS analysis identified three bufadienolides (bufalin, bufotalin, and bufotalinin) in the PGSE.</p><p><strong>Conclusion: </strong>PGSE demonstrates potent cytotoxic activity against colorectal cancer cells, primarily through apoptosis, and contains bufadienolides with known antineoplastic activity. These findings support its potential as a source of bioactive compounds for anticancer research.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3151-3159"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miR-181a-3p, ATR, and HMGB-1 as Integrated Predictors of Induction Blast Clearance in Adults with Acute Myeloid Leukemia.","authors":"Resti Mulya Sari, Lyana Setiawan, Damai Santosa, Melva Louisa, Syarifah Dewi, Ikhwan Rinaldi, Noorwati Sutandyo, Anderson Cenweikiawan","doi":"10.31557/APJCP.2026.27.9.3479","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3479","url":null,"abstract":"<p><strong>Methods: </strong>This study included 71 adult patients with newly diagnosed AML who received standard \"7+3\" induction chemotherapy. Baseline circulating miR-181a-3p and miR-181b-5p levels were quantified using quantitative real-time polymerase chain reaction, while ATM, ATR, and HMGB-1 protein levels were measured using enzyme-linked immunosorbent assay. Induction blast clearance was defined as a post-induction bone marrow blast count of <5%. Receiver operating characteristic (ROC) curve analysis was used to determine optimal cut-off values. Associations were evaluated using Spearman correlation and relative risk (RR) with 95% confidence intervals.</p><p><strong>Results: </strong>Circulating miR-181a-3p demonstrated limited discriminatory performance (AUC = 0.564), while HMGB-1 showed modest performance (AUC = 0.615). Using ROC-derived cut-off values, low baseline miR-181a-3p expression was associated with a significantly higher likelihood of achieving induction blast clearance in monocytic AML (FAB M4-M5) (RR = 2.33, 95% CI: 1.18-4.63, p = 0.015), but not in non-monocytic subtypes. Higher ATR (RR = 1.53, 95% CI: 0.99-2.38, p = 0.047) and HMGB-1 levels (RR = 1.61, 95% CI: 1.04-2.50, p = 0.031) were also associated with improved induction response. Circulating miR-181a-3p correlated with baseline bone marrow blast percentage, suggesting its potential as a surrogate marker for leukemic burden.</p><p><strong>Conclusion: </strong>Circulating miR-181a-3p, ATR, and HMGB-1 are associated with induction blast clearance in AML, with lineage-specific effects observed for miR-181a-3p. Although the individual biomarkers demonstrated limited discriminatory performance, their integration may provide clinically relevant insights into early treatment response.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3479-3485"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Insights into Comparative Genetic Mutations in HPV-Associated and HPV-Independent Cervical Cancer: A Systematic Review.","authors":"Ana Beatriz Camillo Santos, Lucimara Rodrigues Carobeli, Lyvia Eloiza De Freitas Meirelles, Maria Vitória Felipe De Souza, Vânia Ramos Sela Da Silva, Marcia Edilaine Lopes Consolaro","doi":"10.31557/APJCP.2026.27.9.3139","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3139","url":null,"abstract":"<p><strong>Objective: </strong>Cervical cancer remains a major global health burden and is predominantly associated with human papillomavirus (HPV) infection. However, a subset of tumors develops independently of HPV, and their molecular characteristics are not fully understood. This study aimed to synthesize and compare the frequency of somatic mutations across key oncogenic pathways, p53, PI3K-Akt-mTOR, AMPK, and Ras-Raf-MAPK, in HPV-associated and HPV-independent cervical cancers.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines and registered in PROSPERO (CRD420251044316). Comprehensive searches were performed in PubMed, EMBASE, LILACS, Web of Science, Scopus, CINAHL, and Cochrane Central from January 2016 to March 2025 using controlled descriptors related to cervical cancer, somatic mutations, and HPV status. Eligible studies included observational designs reporting cervical cancers with molecular HPV testing and somatic mutation profiling. Data extraction was conducted independently by multiple reviewers and validated by a senior author. Study quality was assessed using STROBE criteria. Extracted variables encompassed sample characteristics, HPV status, sequencing method, genes assessed, and mutation frequencies.</p><p><strong>Results: </strong>Eleven studies comprising 3,479 cervical cancer samples met the inclusion criteria, including 468 (13.4%) HPV-independent tumors. HPV-independent cancers demonstrated higher frequencies of TP53 and CDKN2A mutations, reaching up to 50% and 37.5%, respectively. Alterations in the PI3K-Akt-mTOR pathway, particularly PIK3CA and PTEN, showed heterogeneous patterns, with some studies reporting higher prevalence in HPV-independent tumors and others in HPV-associated tumors. Mutations in ERBB3, NTRK1, ITGB3, TSC2, and TERT were more frequent in HPV-associated cancers, while NTRK3 and RICTOR alterations appeared more common in HPV-independent tumors, although these findings were generally reported in isolated studies. Inconsistencies were also observed for STK11 (AMPK pathway) and KRAS (Ras-Raf-MAPK pathway). Considerable methodological variability limited cross-study comparability.</p><p><strong>Conclusions: </strong>HPV-independent cervical cancers may represent a distinct molecular subgroup, particularly regarding the p53 pathway; however, study heterogeneity limits firm conclusions. Further standardized genomic studies are needed.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3139-3150"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer-Related Quality of Life among Women Undergoing Treatment: A Hospital-Based Study in Vietnam.","authors":"Tuyen Dinh Hoang, Thang Van Vo, Pongdech Sarakarn","doi":"10.31557/APJCP.2026.27.9.3449","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3449","url":null,"abstract":"<p><strong>Background: </strong>Despite the rising incidence of breast cancer (BC), survival rates have improved due to advancements in early detection and treatment. With longer survival, it is increasingly important to evaluate and enhance patients' quality of life (QoL), particularly the functional and symptom-related aspects of BC. This study aims to assess BC-related QoL and its associated factors among women undergoing treatment.</p><p><strong>Method: </strong>A hospital-based cross-sectional study assessed BC-related QoL in 284 patients using the European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire for BC (QLQ-BR45) between March 10 and May 14, 2025. Statistical analyses included multivariable linear regression to identify factors associated with 12 domains of patient QoL.</p><p><strong>Results: </strong>QoL findings showed high body image scores (72.51) but low sexual functioning (13.50) and sexual enjoyment (26.29), with hair-loss distress (51.32) and systemic therapy side effects (30.92) being the most burdensome symptoms. Older age and higher body mass index (BMI) had both positive and negative associations with QoL, while marriage, higher education, urban residence, and longer breastfeeding were linked to better outcomes. Late-stage disease, older age at first childbirth, and receiving no treatment were linked to poorer outcomes. Treatment had varying effects on QoL domains: surgery plus chemotherapy improved sexual enjoyment, while non-surgical approaches alleviated symptoms across several QoL-related domains.</p><p><strong>Conclusion: </strong>BC patients showed strong body image but poor sexual functioning and notable symptom burdens, underscoring the need for supportive care that addresses physical and psychosocial issues. Routine QoL monitoring and broader multicenter studies are essential to guide tailored interventions and improve overall patient QoL.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3449-3456"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco Consumption, Early Initiation, and Determinants Among School-Going Adolescents in Ranchi, Jharkhand: A Cross-Sectional Study.","authors":"Sachender Pal Singh, Priyadarshini Mathew, Niraj Kaushik","doi":"10.31557/APJCP.2026.27.9.3457","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.9.3457","url":null,"abstract":"<p><strong>Objective: </strong>India faces a rapidly increasing burden of oral cancer. Adolescence is a critical period for risk-taking behaviours, yet state-level, school-based data from high-burden regions such as Jharkhand are limited. To estimate the prevalence and patterns of tobacco use and identify socio-demographic, familial, and awareness-related predictors of ever tobacco use among school-going children in Ranchi, Jharkhand.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among 898 students from government and government-aided schools in Ranchi using a pre-tested, structured, self-administered questionnaire. Data included demographics, awareness, tobacco use, social influences, and attitudes toward tobacco control. Ever tobacco use was defined as lifetime use of smoked or smokeless tobacco; current use was defined as use within the past 30 days among ever users. Prevalence was estimated with 95% confidence intervals (CIs). Chi-square tests assessed associations, and logistic regression identified independent predictors.</p><p><strong>Results: </strong>Of 898 students (52.1% girls; mean age 15.6 years), 7.9% (95% CI 6.1-9.7) had ever used tobacco. Among ever users, 22.5% were current users and 50.7% had discontinued. Ever use was higher among boys than girls (12.4% vs 4.1%; OR 3.36, 95% CI 1.95-5.78). However, among ever users, girls were more likely to be current users (OR 5.79, 95% CI 1.74-19.25). Initiation clustered between 10-15 years. In multivariable analysis, male gender (adjusted OR 2.76, 95% CI 1.55-4.93) and family tobacco use (adjusted OR 1.77, 95% CI 1.06-2.95) were independent predictors.</p><p><strong>Conclusion: </strong>Tobacco experimentation begins by mid-adolescence in Ranchi. Prevention should start before age 10, emphasize family-centred strategies, and address social modelling beyond awareness programmes.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 9","pages":"3457-3463"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}